731,465 results match your criteria Urinary Tract Obstruction


Proteinuria, Estimated Glomerular Filtration Rate and Urinary Retinol-Binding Protein as Clinical Predictors of Long-Term Allograft Outcomes in Transplant Glomerulopathy.

Kidney Blood Press Res 2018 Dec 7;43(6):1842-1851. Epub 2018 Dec 7.

Background/aims: We aimed to explore the associations between clinical parameters and long-term allograft outcomes in transplant glomerulopathy (TG) in a large retrospective cohort with long follow-up.

Methods: Clinical and laboratory data at biopsy from 180 cases of TG with an estimated glomerular filtration rate (eGFR)> 15ml/min/1.73m2 from January 2004 to December 2016 at our center were retrospectively analyzed. Read More

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December 2018

In Vivo Assessment of Combined Effects of Glibenclamide and Losartan in Diabetic Rats.

Med Princ Pract 2018 Dec 10. Epub 2018 Dec 10.

Objective: Diabetic complications involve multiple pathological pathways, including hyperglycemia-induced oxidative stress and inflammation. Combination therapy is usually employed to improve treatment outcomes and to lower potential adverse effects. In this study, we evaluated the effects of antidiabetic and antihypertensive agents, glibenclamide (GLI) and losartan (LT), on diabetes-associated metabolic changes in rats. Read More

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December 2018

Prospective study of clinical, neurophysiological and urodynamic findings in multiple scleosis patients undergoing percutaneous transluminal venous angioplasty.

Clin Neurophysiol 2018 Nov 26;130(1):138-144. Epub 2018 Nov 26.

Department of Medicine, Surgery and Neuroscience, Unit of Neurology and Clinical Neurophysiology, University of Siena, Italy. Electronic address:

Objective: Verify whether Percutaneous Transluminal Angioplasty (PTA) may affect neural conduction properties in Multiple Sclerosis (MS) patients, thereby modifying patients' disability, with prospective neurophysiological, urodynamic, clinical and subjective well-being evaluations.

Methods: In 55 out of 72 consecutively screened MS patients, the following procedures were carried out before (T0), at 2-6 months (T1) and at 6-15 months (T2) after a diagnostic phlebography, eventually followed by the PTA intervention if chronic cerebrospinal venous insufficiency (CCSVI) was diagnosed: clinical/objective evaluation (Expanded Disability Status Scale, EDSS), ratings of subjective well-being, evaluation of urodynamic functions and multimodal EPs (visual, acoustic, upper and lower limbs somatosensory and motor evoked potentials).

Results: The number of dropouts was relatively high, and a complete set of neurophysiological and clinical data remained available for 37 patients (19 for urological investigations). Read More

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November 2018

Elevated arsenic exposure and efficient arsenic metabolism in indigenous women around Lake Poopó, Bolivia.

Sci Total Environ 2018 Dec 2;657:179-186. Epub 2018 Dec 2.

Hydrosciences Montpellier, Institut de Recherche pour le Développement, CNRS, University of Montpellier, France.

Elevated concentrations of inorganic arsenic, one of the most potent environmental toxicants and carcinogens, have been detected in well water around Lake Poopó, Bolivia. This study aimed to assess human exposure to arsenic in villages around Lake Poopó, and also to elucidate whether the metabolism and detoxification of arsenic in this population is as efficient as previously indicated in other Andean areas. We recruited 201 women from 10 villages around Lake Poopó. Read More

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December 2018

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting Clinicopathologic features of upper urinary tract urothelial carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, 5309 CCC 5940, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA. Electronic address:

5% of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort.117 UTUC resections with UUT biopsy and/or cytology specimens from 2000-2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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December 2018

Sacral neuromodulation: standardized tined lead implantation technique: two-year clinical outcome and sensory response upon lead stimulation comparing the use of the curved versus straight stylet.

BJU Int 2018 Dec 11. Epub 2018 Dec 11.

Department of Urology, Antwerp University Hospital, Edegem, Belgium.

Objectives: To assess clinical follow-up data over 24 months using the standardized tined lead implantation technique, comparing the use of the curved vs straight stylet.

Patients And Methods: Single tertiary center, prospective study (August 2013 - June 2015) involving 40 patients with overactive bladder and 15 with non-obstructive urinary retention refractory to first-line treatment.

Primary Outcome: successful tined lead procedure; intention to treat analysis at 12 and 24 months. Read More

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December 2018

Long noncoding RNA CASC9 promotes LIN7A expression via miR-758-3p to facilitate the malignancy of ovarian cancer.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Head and Neck and Genito-Urinary Oncology, Harbin Medical University Cancer Hospital, Harbin, China.

The long noncoding RNA cancer susceptibility 9 (CASC9) has been reported to be a pivot modulator in growth and metastasis of breast cancer, liver cancer, esophageal squamous cell carcinoma, lung adenocarcinoma, gastric cancer, and nasopharyngeal cancer. However, its potential roles in ovarian cancer remain unclear. In this study, we aimed at its functions and molecular mechanism in ovarian cancer progression. Read More

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December 2018

HMGB1+ microparticles present in urine are hallmarks of nephritis in patients with systemic lupus erythematosus.

Eur J Immunol 2018 Dec 10. Epub 2018 Dec 10.

Grupo de Inmunología Celular e Inmunogenética, Instituto de Investigaciones Médicas, Facultad de Medicina, Universidad de Antioquia UdeA, Calle 70 No 52-21, Medellín, Colombia.

Non-classical monocytes infiltrate the kidney parenchyma and participate in tissue damage in patients with lupus nephritis (LN). Circulating microparticles (MPs) seem to play critical roles in the activation of monocytes in systemic lupus erythematosus (SLE) patients. This study aims to characterize the phenotypes of MPs and monocyte subsets in LN patients and to determine their potential to discriminate between SLE patients with and without LN. Read More

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December 2018

Dynamic changes of urinary proteins in a rat model of acute hypercoagulable state induced by tranexamic acid.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biochemistry, Beijing Key Laboratory of Genetic Engineering and Biotechnology, College of Life Sciences, Beijing Normal University, Beijing, China.

The hypercoagulable state leads to the development of thrombotic diseases, but it is difficult to diagnose due to the lack of available biomarkers. This study aimed to investigate systematic changes of the urinary proteome in the acute hypercoagulable state. A rat model of the acute hypercoagulable state was induced by an antifibrinolytic agent tranexamic acid and urine samples were collected for proteomic analysis by liquid chromatography-tandem mass spectrometry. Read More

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December 2018

The K 7 channel activator retigabine suppresses mouse urinary bladder afferent nerve activity without affecting detrusor smooth muscle K channel currents.

J Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacology, University of Vermont, Burlington, VT, 05405.

Key Points Summary: K 7 channels are a family of voltage-dependent K channels expressed in many cell types, which open in response to membrane depolarization to regulate cell excitability. Drugs that target K 7 channels are used clinically to treat epilepsy. Interestingly, these drugs also cause urinary retention, but it was unclear how. Read More

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December 2018

Association between Caffeine Consumption in Pregnancy and Low Birth Weight and Preterm Birth in the birth Cohort of Ribeirão Preto.

Rev Bras Ginecol Obstet 2018 Dec 7;40(12):749-756. Epub 2018 Dec 7.

Department of Pediatrics, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto, SP, Brazil.

Objective:  To describe caffeine consumption during pregnancy and its association with low birth weight (LBW) and preterm birth in the birth cohort of Ribeirão Preto, state of São Paulo, Brazil, in 2010.

Methods:  Cohort study, with descriptive and analytical approach. Data included 7,607 women and their newborns in Ribeirão Preto, state of São Paulo, Brazil. Read More

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December 2018
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Increased levels of serum pigment epithelium-derived factor aggravate proteinuria via induction of podocyte actin rearrangement.

Int Urol Nephrol 2018 Dec 7. Epub 2018 Dec 7.

Department of Endocrinology, Southwest Hospital, Third Military Medical University (Army Medical University), 29 Gaotanyan Street, Chongqing, 400038, China.

Purpose: To assess the role of serum pigment epithelium-derived factor (PEDF) in the occurrence and development of proteinuria and renal dysfunction and determine its relevant signaling pathway.

Methods: We analyzed serum PEDF, creatinine, the urinary albumin-to-creatinine ratio, and renal morphology of normal or streptozotocin (STZ)-induced diabetic mice, before and after treatment with PEDF. In vitro, podocytes were stimulated with PEDF under normal or high-glucose conditions; permeability was measured by the transwell assay with fluorescein isothiocyanate (FITC)-dextran; and F-actin cytoskeleton was analyzed by phalloidin staining. Read More

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December 2018

Population Pharmacokinetics and Exposure-Response of Lithium Carbonate in Patients Based on Tubular Reabsorption Mechanisms.

Eur J Drug Metab Pharmacokinet 2018 Dec 7. Epub 2018 Dec 7.

Department of Pharmacy, Fukuoka University Hospital, 7-45-1 Nanakuma, Zyounan-ku, Fukuoka, 814-0180, Japan.

Background And Objective: Lithium, which is used to treat bipolar disorder, has a narrow therapeutic blood concentration range and quickly reaches clinically toxic levels. We performed a population pharmacokinetic analysis with a lithium tubular reabsorption model including urinary pH and investigated the relationship between blood lithium concentration and tremor as a side effect.

Methods: Routine clinical data, including 389 serum concentrations, were collected from 214 patients orally administered an adjusted amount of lithium carbonate. Read More

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December 2018

Novel nomograms to predict recurrence and progression in primary non-muscle-invasive bladder cancer: validation of predictive efficacy in comparison with European Organization of Research and Treatment of Cancer scoring system.

World J Urol 2018 Dec 10. Epub 2018 Dec 10.

Department of Urology, Seoul National University Hospital, Seoul National University College of Medicine, 101 Daehak-ro, Jongno-gu, Seoul, 110-744, Korea.

Purpose: To develop and validate novel nomograms to predict recurrence and progression after transurethral resection of bladder tumor (TURBT) in Korean patients with non-muscle-invasive bladder cancer (NMIBC).

Methods: We retrospectively analyzed the clinical data on 970 newly diagnosed NMIBC patients after TURBT between 2000 and 2013 in a single institution. We used multivariate Cox proportional hazard models to identify the significant predictors of recurrence and progression, which resulted in the construction of the nomograms predicting the 5-year probability of recurrence and progression. Read More

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December 2018

RAB38 promotes bladder cancer growth by promoting cell proliferation and motility.

World J Urol 2018 Dec 10. Epub 2018 Dec 10.

Sino-Singapore Eco-city Hospital of Tianjin Medical University, No. 3333, Hechang Road, Binhai New Area, Tianjin City, 300467, China.

Background: Bladder cancer is the most common malignancy of urinary system with high morbidity and mortality. In general, the development and progression of bladder cancer are complicated pathological processes, and the treatment methods mainly include surgical resection, radiotherapy, chemotherapy, and combined therapy. In recent years, targeted therapy has made progress in the treatment of bladder cancer. Read More

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December 2018

Association Among Sources Exposure of Cadmium in the Adult Non-smoking General Population of Tehran.

Biol Trace Elem Res 2018 Dec 7. Epub 2018 Dec 7.

Center for research on occupational disease, Tehran University of Medical Sciences, Tehran, Iran.

Acute and chronic exposure to cadmium can cause numerous health effects including poisoning, as well as, bone, liver, and kidney diseases. Cadmium competes with iron absorption in blood and can induce anemia. Cadmium body burden can be measured through urine and blood samples. Read More

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December 2018

Assessment of Clinically Meaningful Improvements in Self-Reported Walking Ability in Participants with Multiple Sclerosis: Results from the Randomized, Double-Blind, Phase III ENHANCE Trial of Prolonged-Release Fampridine.

CNS Drugs 2018 Dec 10. Epub 2018 Dec 10.

Biogen, Cambridge, MA, USA.

Background: Walking impairment is a hallmark of multiple sclerosis (MS). It affects > 90% of individuals over time, reducing independence and negatively impacting health-related quality of life, productivity, and daily activities. Walking impairment is consistently reported as one of the most distressing impairments by individuals with MS. Read More

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December 2018

Glomerular isolated microscopic hematuria: urinary features and long term follow-up of a selected cohort of patients.

J Nephrol 2018 Dec 10. Epub 2018 Dec 10.

Clinical and Research Laboratory on Urinary Sediment, U.O.C. di Nefrologia, Dialisi e Trapianto di Rene, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via della Commenda, 15, Milan, Italy.

Background: Isolated microscopic hematuria is a condition characterized by the presence in the urine of an "abnormal" number of erythrocytes in the absence of proteinuria. Several studies have been published on this condition, but with heterogeneous inclusion criteria and variable outcomes at follow-up. In this retrospective study, we describe a selected and homogenous cohort of patients who presented with isolated microscopic hematuria of glomerular origin. Read More

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December 2018

Aortic pulse wave velocity is greater in peritoneal dialysis patients with lower dual energy X-ray absorptiometry (DXA) femoral neck bone mineral density.

J Nephrol 2018 Dec 10. Epub 2018 Dec 10.

UCL Department of Nephrology, Royal Free hospital, University College London, Rowland Hill Street, London, NW3 2PF, UK.

Background: Increased vascular stiffness is associated with low bone mineral density (BMD) in the general population, and both are risk factors for mortality. We wished to determine whether vascular stiffness is associated with BMD in peritoneal dialysis (PD) patients.

Methods: We measured vascular stiffness by aortic pulse wave velocity (aPWV), BMD by dual electron absorptiometry (DXA) scanning, and body composition using bioimpedance. Read More

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December 2018

Role of the mTOR‑FOXO1 pathway in obesity‑associated renal tubulointerstitial inflammation.

Mol Med Rep 2018 Dec 5. Epub 2018 Dec 5.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China.

Since obesity is largely responsible for the growing incidence of renal tubulointerstitial inflammation, exploration into the mechanisms of obesity‑associated tubulointerstitial inflammation is essential. Studies have demonstrated that mammalian target of rapamycin (mTOR) is a crucial molecule in the pathogenesis of renal inflammation, including regulating the expression of inflammatory factors. The purpose of the present study was to further elucidate the role of mTOR in obesity‑associated tubulointerstitial inflammation. Read More

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December 2018

Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes.

J Antimicrob Chemother 2018 Dec 10. Epub 2018 Dec 10.

CIISA - Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.

Objectives: To characterize the population structure, antimicrobial resistance and virulence genes of Klebsiella spp. isolated from dogs, cats and humans with urinary tract infections (UTIs).

Methods: Klebsiella spp. Read More

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December 2018

Low magnesium diet aggravates phosphate-induced kidney injury.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan.

Background: Magnesium is known to protect against phosphate-induced tubular cell injuries in vitro. We investigated in vivo effects of magnesium on kidney injuries and phosphate metabolism in mice exposed to a high phosphate diet.

Methods: Heminephrectomized mice were maintained on a high phosphate/normal magnesium diet or a high phosphate/low magnesium diet for 6 weeks. Read More

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December 2018

A non-invasive biomarker of type III collagen degradation reflects ischaemia reperfusion injury in rats.

Nephrol Dial Transplant 2018 Dec 7. Epub 2018 Dec 7.

Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.

Background: Maintenance of kidney function in kidney allografts remains a challenge, as the allograft often progressively develops fibrosis after kidney transplantation. Fibrosis is caused by the accumulation of extracellular matrix proteins like type I and III collagen (COL I and III) that replace the functional tissue. We assessed the concentrations of a neo-epitope fragment of COL III generated by matrix metalloproteinase-9 cleavage (C3M) in two rat models resembling the ischaemic injury taking place following kidney transplantation. Read More

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December 2018

Seven versus fourteen Days of Antibiotic Therapy for uncomplicated Gram-negative Bacteremia: a Non-inferiority Randomized Controlled Trial.

Clin Infect Dis 2018 Dec 11. Epub 2018 Dec 11.

Infectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.

Background: Gram-negative bacteremia is a major cause of morbidity and mortality in hospitalized patients. Data to guide the duration of antibiotic therapy are limited.

Methods: Randomized, multicenter, open-label, non-inferiority trial. Read More

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December 2018

Validity of predictive equations for 24-h urinary potassium excretion based on timing of spot urine collection among adults: the MESA and CARDIA Urinary Sodium Study and NHANES Urinary Sodium Calibration Study.

Am J Clin Nutr 2018 Sep;108(3):532-547

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD.

Background: 24-h urine collections are the suggested method to measure daily urinary potassium excretion (uK) but are costly and burdensome to implement.

Objective: This study tested how well existing equations with the use of spot urine samples can estimate 24-h uK and if accuracy varies by timing of spot urine collection, age, race, or sex.

Design: This cross-sectional study used data from 407 participants aged 18-39 y from the Washington, DC area in 2011 and 554 participants aged 45-79 y from Chicago in 2013. Read More

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September 2018

The complex human urinary sugar profile: determinants revealed in the cross-sectional KarMeN study.

Am J Clin Nutr 2018 Sep;108(3):502-516

Departments of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Karlsruhe, Germany.

Background: Although sugars and sugar derivatives are an important class of metabolites involved in many physiologic processes, there is limited knowledge on their occurrence and pattern in biofluids.

Objective: Our aim was to obtain a comprehensive urinary sugar profile of healthy participants and to demonstrate the wide applicability and usefulness of this sugar profiling approach for nutritional as well as clinical studies.

Design: In the cross-sectional KarMeN study, the 24-h urine samples of 301 healthy participants on an unrestricted diet, assessed via a 24-h recall, were analyzed by a newly developed semitargeted gas chromatography-mass spectrometry (GC-MS) profiling method that enables the detection of known and unknown sugar compounds. Read More

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September 2018

[Evaluation of susceptibility and response to therapy with piperacillin-tazobactam in patients with infections caused by Escherichia coli with extended-spectrum β-lactamase (ESBL) CTX-M].

Rev Chilena Infectol 2018 Aug;35(4):343-350

Departamento de Enfermedades Infecciosas, Escuela de Medicina, Pontificia Universidad Católica de Chile, Chile.

Background: Carbapenems are the preferred β-lactamics for treatment for infections caused by enterobacteria producing extended-spectrum β-lactamases (ESBL); however, clinical studies show effectiveness of piperacillin/tazobactam in certain infections by Escherichia coli ESBL producers.

Aim: To determine the clinical and micro-biological cure with piperacillin/tazobactam in patients with infections caused by E. coli ESBL producers, CTXM type. Read More

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[Susceptibility to first-generation Cephalosporins in Enterobacteriaceae isolated from urine culture according to CLSI and EUCAST breakpoints].

Rev Chilena Infectol 2018 ;35(3):329-331

Clínica Las Condes, Laboratorio de Microbiología, Chile.

Currently, the use of cefazolin is recommended to determine the susceptibility to first-generation oral cephalosporins in strains of enterobacteria in uncomplicated UTI. We determined susceptibility differences to oral cephalosporins in urinary strains according to cefazolin or cefalotin breakpoints and the correlation of susceptibility between cefazolin and cefadroxil. We studied 52 strains with cefalotin and cefazolin by disk-diffusion and MIC (Kirby-Bauer and Vitek XL) and a subgroup by disk-diffusion for cefadroxil. Read More

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January 2018

[Nosocomial urinary tract infection: an analysis beyond urinary catheterization].

Rev Chilena Infectol 2018 ;35(3):246-252

Servicio de Medicina Interna, Hospital Privado Universitario de Córdoba, Instituto Universitario de Ciencias Biomédicas de Córdoba, Córdoba, Argentina.

Introduction: Nosocomially acquired urinary tract infections (NAUTI) represent an important public health issue, but its characteristics when they are not catheter associated (CA-UTI) or when they take place outside intensive care units (ICU) are poorly understood.

Objectives: To determine the patients' characteristics, etiology and antimicrobial susceptibility of NAUTI, both CA-UTI and no CA-UTI, in general ward and ICU.

Methods: We conducted a retrospective analytic cross-sectional study, between 2009 and 2013, in a third level universitary hospital. Read More

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January 2018

[Spontaneous remission of acromegaly and Cushing's disease in older patients. Report of two cases].

Rev Med Chil 2018 Jul;146(7):933-937

Departamento de Neurología y Neurocirugía, Hospital Clínico de la Universidad de Chile, Santiago, Chile.

Pituitary diseases such as acromegaly and Cushing's disease require surgical or medical therapy. In some functioning pituitary tumors, a spontaneous remission of hormonal hypersecretion is observed, mainly associated to apoplexy or pituitary infarction. We report the evolution of two female patients older than 70 years at the time of diagnosis, with multiple comorbidities. Read More

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July 2018
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[Directed acyclic graphs in statistical modelling of epidemiological studies].

Rev Med Chil 2018 Jul;146(7):907-913

Programa de Salud Ambiental, Escuela de Salud Pública, Universidad de Chile, Santiago, Chile.

Background: Confusion in observational epidemiological studies distorts the relationship between exposure and event. "Step by step" regression models, diverts the decision to a statistical algorithm with little causal basis. Directed Acyclic Graphs (DAGs), qualitatively and visually assess the confusion. Read More

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[Porphyria cutanea tarda. Case report].

Rev Med Chil 2018 Aug;146(8):943-946

Escuela de Medicina, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.

Porphyria cutanea tarda (PCT) is the most common type of porphyria: it is characterized by blistering lesions, erosions and crusts on the back of the hands, associated with photosensitivity and facial hypertrichosis. It is produced by acquired or hereditary deficiency of the enzyme UROD, fifth enzyme in the chain of production of the Heme group. This causes accumulation of porphyrins in the liver, which are subsequently mobilized to the skin, where lesions are generated by photosensitivity. Read More

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Bipolar en bloc tumor resection versus standard monopolar TURBT - which is the best way to go in non-invasive bladder cancer?

Rom J Morphol Embryol 2018 ;59(3):773-780

Department of Nephrology and Dialysis, "St. John" Emergency Clinical Hospital, Clinical Department No. 3, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania;

The aim of the study was to observe similarities and differences regarding surgical safety and prognosis between en bloc bipolar resection and monopolar transurethral resection of bladder tumors (TURBTs) in medium size papillary non-muscle invasive bladder tumors (NMIBTs). A total of 90 patients with papillary bladder tumors presenting a diameter between 1 and 3 cm were equally divided and alternatively assigned for en bloc bipolar ablation (the study group) and conventional TURBT (the control group). During one year, every three months, the follow-up was performed and the protocol included urinary cytology and cystoscopy. Read More

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January 2018

Abdominal ultrasound in paraneoplastic Pyoderma gangrenosum caused by renal carcinoma.

Med Ultrason 2018 Dec;20(4):541-542

2nd Medical Clinic, UMF Iuliu Hatieganu University, Cluj-Napoca, Romania.

We present the case of a 60-year-old male patient, with refractory ulcers in the groin. Ultrasoundand CT showed a large vascularized tumor of the kidney with cystic parts and inhomogeneous dynamic behaviour. Histology demonstrated Pyoderma gangrenosum (ulcer) and well differentiated adenocarcinoma (kidney). Read More

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December 2018

Artificially Cultivated Alleviates Diabetic Nephropathy and Its Podocyte Injury via Inhibiting P2X7R Expression and NLRP3 Inflammasome Activation.

J Diabetes Res 2018 11;2018:1390418. Epub 2018 Nov 11.

Division of Nephrology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

Background/aims: It is known that chronic low-grade inflammation contributes to the initiation and development of both diabetes and diabetic nephropathy (DN), so we designed this study to investigate the role of P2X7R and NLRP3 inflammasome in DN pathogenesis and the antagonistic effects of artificially cultivated (ACOS).

Methods: A rat model of DN caused by high-fat-diet feeding and low-dose streptozotocin injection and a mouse podocyte injury model induced by high-glucose (HG) stimulation were established, and the intervention effects of ACOS on them were observed. The biological parameters of serum and urine and the pathological manifestations of kidney tissue were examined. Read More

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November 2018

The use of a string with a stent for self-removal following ureteroscopy: A safe practice to remain.

Arab J Urol 2018 Dec 27;16(4):435-440. Epub 2018 Jun 27.

Department of Surgery, Division of Urology, Baylor Scott and White Health, Temple, TX, USA.

Abstract Objectives: To examine the safety and effectiveness of the use of a stent with a string attached after ureteroscopy (URS) for self-removal of the stent by the patient.

Patients And Methods: After Institutional Review Board approval, a retrospective chart review was performed concerning patients who underwent URS and received an indwelling stent with or without a string attached to the stent (94 vs 349, respectively). Amongst the string group patients received a single- or a double-arm-stringed stent (31 vs 63, respectively). Read More

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December 2018

Simultaneous antegrade and retrograde endoscopic surgery for benign prostatic hyperplasia with vesical calculi - A single-centre experience.

Arab J Urol 2018 Dec 11;16(4):417-421. Epub 2018 Jun 11.

M.S. Ramaiah Hospital, Bangalore, India.

Objective: To describe the effectiveness and safety of our novel technique of simultaneous percutaneous cystolithotripsy with transurethral resection of prostate (TURP) for patients with benign prostatic hyperplasia (BPH) complicated with large vesical calculi.

Patients And Methods: This was a retrospective analysis of 25 patients who underwent simultaneous percutaneous cystolithotripsy with TURP between January 2012 and January 2016. Technique: A 28-F Amplatz sheath was inserted percutaneously into the bladder after sequential dilatation under cystoscopic guidance. Read More

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December 2018

Thulium laser enucleation of the prostate (ThuLEP): Results, complications, and risk factors in 139 consecutive cases.

Arab J Urol 2018 Dec 5;16(4):411-416. Epub 2018 Jul 5.

Department of Urology and Men's Health, Al Garhoud Private Hospital, Dubai, United Arab Emirates.

Objectives: To report our experience with the emerging technique of thulium laser enucleation of the prostate (ThuLEP) for the treatment for prostate hyperplasia.

Patients And Methods: Our inclusion criteria were an International Prostate Symptom Score (IPSS) of >15 and a quality-of-life (QoL) score of >3 in patients with confirmed bladder outflow obstruction, no longer responsive to medical therapy, with a significant post-void residual urine volume (PVR; >100 mL), with or without recurrent urinary tract infection and/or acute urinary retention. Patients with neurogenic bladder, urethral strictures, bladder stones, and previously failed transurethral prostate surgery were excluded. Read More

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December 2018

Oral desmopressin in nocturia with benign prostatic hyperplasia: A systematic review of the literature.

Arab J Urol 2018 Dec 25;16(4):404-410. Epub 2018 Jul 25.

Department of Urology, Urology and Nephrology Center, Mansoura University, Mansoura, Egypt.

Objective: To evaluate the effect of oral desmopressin in patients with nocturia associated with benign prostatic hyperplasia (BPH).

Patients And Methods: With a rise of the use of oral desmopressin in the treatment of nocturia in patients with BPH, a systematic review was performed according to the Cochrane systematic reviews guidelines and in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist.

Results: The literature search yielded 18 studies. Read More

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December 2018

Autologous versus synthetic slings in female stress urinary incontinence: A retrospective study.

Arab J Urol 2018 Dec 9;16(4):397-403. Epub 2018 Jul 9.

Department of Urology, Faculty of Medicine, Ain Sham University, Cairo, Egypt.

Objective: To evaluate and compare the clinical (patient's morbidity, quality of life [QoL]) and economic impact of autologous vs synthetic slings in female stress urinary incontinence (SUI), as over the last decade, the introduction of synthetic vaginal tapes for managing SUI has gained wide acceptance being quicker with low morbidity. Synthetic vaginal tapes have been progressively replacing the use of autologous rectus fascia. However, the high cost of these synthetic tapes is almost always an obstacle for most patients of limited socio-economic resources in the Egyptian community. Read More

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December 2018

The first Iraqi experience in sacral neuromodulation for patients with lower urinary tract dysfunction.

Arab J Urol 2018 Dec 7;16(4):391-396. Epub 2018 Aug 7.

Department of Neurosurgery, Al-Mustansiriya University, Baghdad, Iraq.

Objectives: To present our experience, in Iraq, with sacral neuromodulation (SNM) in patients with refractory lower urinary tract dysfunction, with discussion of the factors that affect the response rate.

Patients And Methods: In this prospective, clinical, interventional study, 24 patients were evaluated and treated by a team comprised of a Urologist and a Neurosurgeon with SNM over a 1.5-year period. Read More

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December 2018

User perception of a new hydrophilic-coated male urinary catheter for intermittent use.

Nurs Open 2019 Jan 4;6(1):116-125. Epub 2018 Sep 4.

Radboudumc Nijmegen The Netherlands.

Aims: This study investigated user perception and adherence related to a hydrophilic-coated urinary catheter (LoFric® Origo™), available for male patients who practice intermittent catheterization.

Design: The study had a prospective observational design, including patients from 19 European hospitals.

Methods: A total of 416 patients were eligible for the study; 179 experienced catheter users and 237 de novo. Read More

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January 2019

Draft Genome Sequence of Enterococcus faecium CL-6729, a Clinical Isolate Showing Constitutive Vancomycin Resistance.

Microbiol Resour Announc 2018 Nov 21;7(20). Epub 2018 Nov 21.

Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Here, we present the draft genome sequence of an unusual Enterococcus faecium isolate (CL-6729) showing constitutive expression of the VanA type of vancomycin resistance. The isolate was recovered from a patient with a nosocomial urinary tract infection in Brazil. Read More

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November 2018

Urethral calculi: A rare cause of acute urinary retention in women.

Turk J Emerg Med 2018 Dec 23;18(4):170-171. Epub 2018 Feb 23.

TOBB Economy and Technology University, Faculty of Medicine, Department of Urology, Yaşam Caddesi No: 5 Söğütözü, 06510, Ankara, Turkey.

Urinary retention is defined as the inability to void; frequently the patient is able to void partially, thus can not completely empty the bladder and diagnosed by increased post-void residual urine (PVR) volumes. It is usually seen in men, but a rare condition in women. The etiological factors may be neurological, anatomical, infectious or pharmacological. Read More

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December 2018

Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria.

Res Rep Urol 2018 16;10:219-225. Epub 2018 Nov 16.

Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA,

Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Read More

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November 2018

Comparison of Three-Quadrant Transversus Abdominis Plane Block and Continuous Epidural Block for Postoperative Analgesia After Transperitoneal Laparoscopic Nephrectomy.

Anesth Pain Med 2018 Oct 3;8(5):e80024. Epub 2018 Sep 3.

Department of Anesthesiology and Intensive Care, Universitas Indonesia, Jakarta, Indonesia.

Background: Postoperative pain management is important for the early recovery of the living donor patient. Patient-controlled opioid analgesia, epidural analgesia, or a combination of both is the preferred pain management after abdominal surgery although these approaches have serious side effects. The transversus abdominis plane (TAP) block has been increasingly used for postoperative pain management and the addition of dexamethasone to local anesthetic can prolong the duration of action. Read More

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October 2018

The Impact of Automated Electronic Surveillance of Electronic Medical Records on Pediatric Inpatient Care.

Cureus 2018 Oct 1;10(10):e3395. Epub 2018 Oct 1.

Pediatrics, Nemours Children's Hospital, Orlando, USA.

Purpose To assess the impact of the automated surveillance of the electronic medical record process on clinical interventions among hospitalized children at a tertiary care pediatric center. Methods A retrospective chart review of the alerts triggered for central line-associated blood stream infections (CLABSIs), catheter-associated urinary tract infections (CAUTIs), neonatal sepsis, or clinical deterioration through elevated pediatric early warning scores (PEWS) by automated electronic surveillance of the hospital electronic medical record (EMR) over a five-month period among hospitalized children. Interventions instituted in response to the alerts were reviewed from the hospital EMR. Read More

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October 2018

Identification of key candidate genes and biological pathways in bladder cancer.

PeerJ 2018 4;6:e6036. Epub 2018 Dec 4.

Central Laboratory, Central South University Xiangya School of Medicine Affiliated Haikou Hospital, Haikou, China.

Background: Bladder cancer is a malignant tumor in the urinary system with high mortality and recurrence rates. However, the causes and recurrence mechanism of bladder cancer are not fully understood. In this study, we used integrated bioinformatics to screen for key genes associated with the development of bladder cancer and reveal their potential molecular mechanisms. Read More

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December 2018

Ureteral obstruction by sloughed tumor complicating cryoablation of a renal oncocytoma.

Radiol Case Rep 2018 Dec 14;13(6):1195-1198. Epub 2018 Sep 14.

Department of Radiology, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, Japan 700-8558.

Percutaneous cryoablation for renal tumors may be associated with rare complications such as injury to the ureter. A 65-year-old woman underwent percutaneous cryoablation after a transcatheter arterial embolization using lipiodol and ethanol for left renal oncocytoma. Two months after the percutaneous cryoablation, computed tomography images showed left hydronephrosis caused by high-density debris, which was assumed to be sloughed tumor with lipiodol accumulation in the left ureter. Read More

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December 2018

Health care-associated infections - an overview.

Infect Drug Resist 2018 15;11:2321-2333. Epub 2018 Nov 15.

Faculty of Medicine and Defence Health, Universiti Pertahanan Nasional Malaysia (National Defence University of Malaysia), Kem Sungai Besi, 57000 Kuala Lumpur, Malaysia,

Health care-associated infections (HCAIs) are infections that occur while receiving health care, developed in a hospital or other health care facility that first appear 48 hours or more after hospital admission, or within 30 days after having received health care. Multiple studies indicate that the common types of adverse events affecting hospitalized patients are adverse drug events, HCAIs, and surgical complications. The US Center for Disease Control and Prevention identifies that nearly 1. Read More

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November 2018
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