731,622 results match your criteria Urinary Tract Infections in Pregnancy
Int Urol Nephrol 2018 Dec 13. Epub 2018 Dec 13.
Department of Visceral Surgery, Faculty of Medicine, Children's Hospital Canastel, University of Oran, Oran, Algeria.
Purpose: To report current results of vaginoplasty using the mucosa of the prepuce, and creating labia minora by penile skin in children with disorders of sex development (DSD).
Methods: In 10 years, we have performed 22 vaginoplasties using the described technique of vaginoplasty, 21 patients with 46, XX DSD and 1 ovotesticular DSD. The assessment of the results of this technique of vaginoplasty was undertaken in several stages: (a) The evaluation of the cosmetic result. Read More
J Spine Surg 2018 Sep;4(3):602-609
Department of Plastic and Reconstructive Surgery, Uppsala University Hospital, Uppsala, Sweden.
Background: The optimal treatment of symptomatic perineural (Tarlov) cysts is controversial. Numerous surgical techniques have been proposed with conflicting results. A series of Tarlov cysts treated with a novel surgical approach is presented. Read More
Clin Transl Radiat Oncol 2019 Jan 17;14:51-58. Epub 2018 Nov 17.
Department of Urology, Nara Medical University, Japan.
Purpose: To investigate chronological changes in lower urinary tract symptoms (LUTS) in patients who received iodine-125 brachytherapy (BT) for prostate cancer.
Methods: We enrolled 706 patients who received BT. Of these, 265 (38%) received BT combined with external beam radiation therapy (EBRT). Read More
JFMS Open Rep 2018 Jul-Dec;4(2):2055116918815323. Epub 2018 Dec 3.
Department of Clinical Sciences and Advanced Medicine, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA, USA.
Case Summary: A 15-year-old female spayed domestic shorthair cat was presented for hyporexia and acute development of L4-Cd myelopathy (urinary incontinence, pelvic limb paresis with hyporeflexia and absent tail tone). Humane euthanasia was elected owing to the rapid neurological deterioration and necropsy was performed. Post-mortem examination identified a right-sided anal sac mass and medial iliac lymphadenopathy. Read More
Eur Geriatr Med 2018 27;9(6):783-793. Epub 2018 Sep 27.
14Department of Internal Medicine, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria.
Purpose: Inappropriate use of diagnostic and therapeutic medical procedures is common and potentially harmful for older patients. The Austrian Society of Geriatrics and Gerontology defined a consensus of five recommendations to avoid overuse of medical interventions and to improve care of geriatric patients.
Methods: From an initial pool of 147 reliable recommendations, 20 were chosen by a structured selection process for inclusion in a Delphi process to define a list of five top recommendations for geriatric medicine. Read More
Front Neurosci 2018 28;12:848. Epub 2018 Nov 28.
Clinical Department of Medical Psychology, Medical University of Innsbruck, Innsbruck, Austria.
This "integrative single-case study" investigated the bidirectional cause and effect relations between various emotional states (i.e., mood, irritation, mental activity) and urinary IL-6 levels in a 49-year-old female breast cancer survivor (woman) under conditions of "life as it is lived. Read More
J Korean Med Sci 2018 Dec 22;33(51):e324. Epub 2018 Nov 22.
Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.
Oxysterol 7α-hydroxylase deficiency is a very rare liver disease categorized as inborn errors of bile acid synthesis, caused by mutations. As it may cause rapid progression to end-stage liver disease even in early infancy, a high index of suspicion is required to prevent fatal outcomes. We describe the case of a 3-month-old boy with progressive cholestatic hepatitis and severe hepatic fibrosis. Read More
Hypertens Res 2018 Dec 13. Epub 2018 Dec 13.
Department of Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.
The lack of a decrease in nocturnal blood pressure is a risk factor for the progression of chronic kidney disease (CKD); however, it currently remains unknown whether it is a risk factor in normotensive CKD patients. We conducted a retrospective cohort study and enrolled 676 CKD patients who underwent ambulatory blood pressure monitoring (ABPM). According to their nocturnal blood pressure dipping pattern (>10%: dipper or <10%: non-dipper) and average 24-h systolic blood pressure (>130/80 mmHg: hypertension or <130/80 mmHg: normotension), patients were divided into four groups. Read More
Pediatr Res 2018 Dec 13. Epub 2018 Dec 13.
Golisano Children's Hospital, University of Rochester, Rochester, NY, USA.
Background: Most studies of neonatal acute kidney injury (AKI) have focused on the first week following birth. Here, we determined the outcomes and risk factors for late AKI (>7d).
Methods: The international AWAKEN study examined AKI in neonates admitted to an intensive care unit. Read More
J Diabetes Complications 2018 Nov 22. Epub 2018 Nov 22.
Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt. Electronic address:
Aims: Diabetic nephropathy (DN) that progress to end stage renal failure is a serious health problem. Autophagy is involved in DN pathogenesis. Finding renal prognostic biomarkers can help in the future renal status prevision. Read More
Taiwan J Obstet Gynecol 2018 Dec;57(6):867-870
Department of Obstetrics and Gynecology, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan; Department of Obstetrics and Gynecology, Hsin-Chu Br, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
Objective: Ureterocele in a duplex system is rare and commonly presented with urinary tract infection at neonatal age, infant or childhood. Symptomatic ureterocele in reproductive-age is a diagnostic challenge and should be highly awarded to avoid miss-diagnosis.
Case Report: An adolescent girl with right ectopic ureterocele presented as acute abdomen that mimicked ovarian torsion received emergent laparoscopic surgery. Read More
Taiwan J Obstet Gynecol 2018 Dec;57(6):853-857
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao, New Taipei, Taiwan; Department of Obstetrics and Gynecology, National Taiwan University College of Medicine and the Hospital, Taipei, Taiwan. Electronic address:
Objective: To assess the impact of the transobturator mid-urethral sling (MUS) procedure on female sexual function and their partners' sexual activity.
Materials And Methods: Sexually active women with stress urinary incontinence who underwent a transobturator MUS procedure at the Department of Obstetrics and Gynecology of two medical centers were prospectively enrolled. All participants and their partners were required to complete questionnaires before surgery and 3 months after surgery. Read More
Taiwan J Obstet Gynecol 2018 Dec;57(6):825-829
School of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:
Objective: Female pelvic floor disorders, including female stress urinary incontinence (SUI) or sexual dysfunction are notorious for affecting the quality of women's life. It is reported that laser therapy might result in collagen remodeling and improvement in tissue firmness. The study was conducted to evaluate the short-term outcome of female pelvic floor disorders treated by laser therapy. Read More
Taiwan J Obstet Gynecol 2018 Dec;57(6):777-778
Department of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Obstetrics and Gynecology, National Yang-Ming University, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. Electronic address:
Tech Vasc Interv Radiol 2018 Dec 30;21(4):261-266. Epub 2018 Jul 30.
Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC.
Image-guided percutaneous nephrostomy is a relatively safe and successful procedure for access to the renal collecting system for multiple purposes including relief of urinary obstruction, urinary diversion, access for endourologic procedures, and diagnostic testing. Although placing a percutaneous nephrostomy catheter is most times straightforward, providing immediate benefit for the patient and satisfaction for the practitioner, there can be situations that make the procedure more difficult or risky. A thorough review of the patient's imaging and medical record will help to set a path for success. Read More
Int J Med Inform 2019 Jan 23;121:53-57. Epub 2018 Oct 23.
Austin Health, Department of Radiation Oncology, Melbourne, Australia; Department of Cancer Medicine, Latrobe University, Melbourne, Australia.
Objectives: To implement a system for unsupervised extraction of tumor stage and prognostic data in patients with genitourinary cancers using clinicopathological and radiology text.
Methods: A corpus of 1054 electronic notes (clinician notes, radiology reports and pathology reports) was annotated for tumor stage, prostate specific antigen (PSA) and Gleason grade. Annotations from five clinicians were reconciled to form a gold standard dataset. Read More
BMC Urol 2018 Dec 13;18(1):115. Epub 2018 Dec 13.
Department of Urology, Beijing Huairou Hospital, Beijing, 101400, China.
Background: To study nocturia in patients with lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) after medical or placebo treatment.
Methods: Patients with LUTS suggestive of BPH from several community clinics were included. Patients completed the International Prostate Symptom Score (I-PSS) questionnaire and a 3-day voiding diary. Read More
BMC Urol 2018 Dec 13;18(1):114. Epub 2018 Dec 13.
The Department of Clinical Laboratory, The Sixth People's Hospital of Nansha, Xingye Road No. 7, Dagang Town, Nansha, Guangzhou, 511470, People's Republic of China.
Background: To provide some basis for the prevention of urinary stones in general population, we did a systemic analysis of urinary stones from Northern, Eastern, Central, Southern and Southwest China by a multi-center study.
Methods: A total of 11,157 urinary stones from Northern, Eastern, Central, Southern and Southwest China were obtained and analyzed by Fourier transform infrared spectroscopy. Combined with scanning electron microscopy and X-ray energy spectrometer, urinary stones were classified into different types. Read More
Proteomes 2018 Dec 9;6(4). Epub 2018 Dec 9.
J. Craig Venter Institute, 9605 Medical Center Drive, Rockville, MD 20850, USA.
, a Gram-positive anaerobic coccoid rod colonizing the human urinary tract, belongs to the taxonomic class of Actinobacteria. We identified as a cohabitant of urethral catheter biofilms (CB). The CBs also harbored more common uropathogens, such as and , supporting the notion that is adapted to a life style in polymicrobial biofilms. Read More
Med Sci (Basel) 2018 Dec 7;6(4). Epub 2018 Dec 7.
Department of Medical Biology, School of Medicine, Marmara University, Istanbul,34899, Turkey.
Bladder cancer is the 10th-most common cancer worldwide. The diagnosis and follow-up of patients require costly invasive methods and due to these expenses, bladder cancer continues to be one of the expensive malignancies. Early diagnosis is crucial in bladder cancer as it is in other cancers; therefore, non-invasive biomarkers for early diagnosis are very important. Read More
Nutrients 2018 Dec 7;10(12). Epub 2018 Dec 7.
ViroMed Co. Ltd., Building 203, Seoul National University, Seoul 151-742, Korea.
Benign prostatic hyperplasia (BPH) is a common disease in the elderly male population throughout the world. Among other factors, androgen dysregulation has been known to play major roles in its pathogenesis. HX109 is a botanical formulation prepared from a mixture of , , and , which have traditionally been used-usually along with other plants-to treat urinary diseases. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13474
Department of Urology, Institute of Urology, West China Hospital, Sichuan University.
Rationale: Inflammatory myofibroblastic tumors of the urinary bladder (IMTUB) is exceptionally rare. Currently, no standardized treatment has been established for IMTUBs.
Patient Concerns: Herein we report three cases presenting with hematuria and anemia. Read More
Medicine (Baltimore) 2018 Dec;97(49):e13006
Department of Pediatrics, Tri-Service General Hospital, Department of Microbiology and Immunology, National Defense Medical Center, Taipei, Taiwan.
Obesity may increase the risk of infection, but the association between obesity and febrile urinary tract infection (fUTI) is controversial. Although the prevalence of infant and childhood obesity has been increasing worldwide, the results of previous investigations on the association with urinary tract infection (UTI) are conflicting. The purpose of this study was to evaluate the relationship between overweight and obesity and UTI in febrile children. Read More
Aktuelle Urol 2018 Dec 13;49(6):e94. Epub 2018 Dec 13.
Spital Thurgau AG, Urologie, Frauenfeld.
Hinyokika Kiyo 2018 Nov;64(11):445-450
The Department of Urology, Kobe City Nishi-Kobe Medical Center.
We describe two cases of inflammatory myofibroblastic tumor (IMT) of the urinary bladder. Case 1 : A 55-year-old man complained of urinary frequency. Transurethral biopsy of the bladder tumor was performed ; pathological examination revealed IMT. Read More
Hinyokika Kiyo 2018 Oct;64(10):409-413
The Department of Kidney Transplant Surgery, Sapporo City General Hospital.
We report a patient who developed urinary retention due to the presence of necrotic tissues in the bladder 5 months after kidney transplantation. The patient was a 47-year-old female who had been diagnosed with immunoglobulin A nephropathy. She requested to receive a living-donor kidney transplant from her husband, and was referred to our hospital. Read More
Hinyokika Kiyo 2018 Oct;64(10):403-407
The Department of Pathology, Osaka Rosai Hospital.
We report a case of renal pelvic cancer found after left renal trauma. A 63-year-old man was admitted to our hospital because of gross hematuria after he had fallen down the stairs two days earlier. He had asymptomatic severe anemia (Hb : 3. Read More
PLoS One 2018 13;13(12):e0209014. Epub 2018 Dec 13.
First Affiliated Hospital of Kunming Medical University, Kunming, People's Republic of China.
Three arsenic species in urine are measured using an atomic absorption spectrophotometer. RT-PCR is performed to detect the expression levels of AS3MT, 3 miRNAs, and 17 relative mRNAs in 43 workers producing arsenic trioxide, 36 workers who stopped exposure to arsenic for 85 days, and 24 individuals as the control group. The concentrations of urinary arsenic are very high in workers. Read More
PLoS Pathog 2018 Dec 13;14(12):e1007457. Epub 2018 Dec 13.
Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.
Urinary tract infections (UTI) are extremely common and can be highly recurrent, with 1-2% of women suffering from six or more recurrent episodes per year. The high incidence of recurrent UTI, including recurrent infections caused by the same bacterial strain that caused the first infection, suggests that at least some women do not mount a protective adaptive immune response to UTI. Here we observed in a mouse model of cystitis (bladder infection) that infection with two different clinical uropathogenic Escherichia coli (UPEC) isolates, UTI89 or CFT073, resulted in different kinetics of bacterial clearance and different susceptibility to same-strain recurrent infection. Read More
J Med Microbiol 2018 Dec 13. Epub 2018 Dec 13.
3Norwich Medical School, Norwich Research Park, Colney Lane, Norwich NR4 7TJ, UK.
Purpose: With an increase in the numbers of bacterial isolates resistant to first-line antibiotics, there has been a revival in the use of older drugs including fosfomycin with novel mechanisms of action. We aimed to investigate the prevalence and genotypic nature of fosfomycin resistance in Escherichia coli from urinary tract infections (UTIs) using the various methods available in the clinical microbiology laboratory.
Methodology: In total, 1000 culture-positive urine samples were assessed for the presence of E. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):643-650
Département de biochimie et hormonologie, CHU de Montpellier, France.
Urinary proteins or urinary albumin exhibit a high intra individual variability. Therefore, urine collected during 24 hours has been recognized as a reference biological fluid for usual values determination. However, urine collection during a day is difficult and numerous studies have been performed to replace the "gold standard" with measures on random samples and results given as protein/creatinine ratio or albumin/creatinine ratio, to decrease the variability. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):638-642
Laboratoire national de métrologie et d'essais, Paris, France.
Measurement of urine albumin has been introduced in the new classification of kidney disease (KD) as a marker for detecting, monitoring and predicting KD. Currently, the measure is not standardized. The variability of results obtained with commercially available procedures is important and can lead to misclassification of patients. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):633-637
Laboratoire de biochimie et biologie moléculaire, GH Sud Hospices civils de Lyon, France.
The quantification of urine albumin is a common practice in Medical Biology laboratories. It allows the assessment of renal injury in common pathologies and many studies have confirmed its role in the diagnosis and prognosis of these disorders. The physicochemical characteristics of albumin in the urine, very different from those in the blood, do not allow the use of the same standardized assay techniques for the blood albumin determination and make it difficult its quantification. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):627-631
Laboratoire de biochimie, Centre hospitalier universitaire de Nantes, France.
Today, there is no reference method for the measurement of urinary proteins. The difficulties are that urine is a very complex biological fluid, and that there are a high intra-and inter-individual variability in the protein excretion rate. Progress has been made during the last thirty years, but high analytical variability persists among the colorimetric or turbidimetric methods used for urinary proteins measurement. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):617-626
Université de Liège, Service de chimie médicale, CHU Sart Tilman (CHU ULg), Liège, Belgique.
Urine is an easily accessible biological fluid. This availability makes it tempting for a direct analysis of urinary parameters by physicians. Urinary proteins, that are interesting markers for several pathologies, are detected by urinary strips, rapidly and at a low cost. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):609-616
Laboratoire de biochimie, CHU de Toulouse, France.
The preanalytical phase is a key step in urinary protein measurement. It is a complex step, which includes urine sampling, storage and transport to the laboratory and preparation for analysis of the specimen. It can lead to numerous errors, since urine sampling is made by the patient himself. Read More
Ann Biol Clin (Paris) 2018 Dec;76(6):607-608
Département de biochimie et hormonologie, CHU Lapeyronie, Montpellier, France.
EJNMMI Res 2018 Dec 12;8(1):108. Epub 2018 Dec 12.
Department of Nuclear Medicine and Molecular Imaging, Lausanne University Hospital, Lausanne, Switzerland.
Background: Gastrin-releasing peptide receptor antagonists have promise in theranostics of several highly incident tumours, including prostate and breast. This study presents the first human dosimetry of Ga-NODAGA-MJ9 in the first five consecutive patients with recurrent prostate cancer included in a dual-tracer positron emission tomography (PET) protocol. Five male patients with biochemical relapse of prostate adenocarcinoma underwent four whole-body time-of-flight PET/CT scans within 2 h after tracer injection. Read More
Support Care Cancer 2018 Dec 12. Epub 2018 Dec 12.
Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Purpose: Physical activity (PA) has been shown to improve quality of life and survival in cancer survivors; however, a cancer diagnosis may change PA patterns. We examine determinants of changes in meeting the PA guidelines (150 min/week of moderate aerobic PA) before and after a prostate cancer diagnosis.
Methods: Eight hundred and thirty prostate cancer survivors who participated in a population-based case-control study between 1997 and 2000 in Alberta, Canada, enrolled in a prospective cohort study. Read More
J Med Toxicol 2018 Dec 12. Epub 2018 Dec 12.
Carolinas Poison Center, Charlotte, NC, USA.
Introduction: Gadolinium-based contrast agents (GBCA) have been used to enhance magnetic resonance imaging (MRI) since 1985. Recently, the media and online groups have voiced concerns about gadolinium deposition in patients with normal renal function based on "elevated" urinary gadolinium levels. The determination of increased urinary gadolinium levels is based on reference ranges developed in individuals with normal renal function who were never exposed to GBCA. Read More
MMW Fortschr Med 2018 Dec;160(21-22):43-46
Klinik für Urologie, Barmherzige Brüder München, Romanplatz 93, D-80639, München, Deutschland.
MMW Fortschr Med 2018 Dec;160(21-22):46-50
Klinik für Urologie, Barmherzige Brüder München, Romanplatz 93, D-80639, München, Deutschland.
Ann Biomed Eng 2018 Dec 12. Epub 2018 Dec 12.
Department of Bioengineering, Clemson University, Clemson, SC, USA.
Although the previous success of bladder tissue engineering demonstrated the feasibility of this technology, most polyester based scaffolds used in previous studies possess inadequate mechanical properties for organs that exhibit large deformation. The present study explored the use of various biodegradable elastomers as scaffolds for bladder tissue engineering and poly (carbonate-urethane) urea (PCUU) scaffolds mimicked urinary bladder mechanics more closely than polyglycerol sebacate-polycaprolactone (PGS-PCL) and poly (ether-urethane) urea (PEUU). The PCUU scaffolds also showed cyto-compatibility as well as increased porosity with increasing stretch indicating its ability to aid in infiltration of smooth muscle cells. Read More
Exp Ther Med 2018 Dec 14;16(6):4664-4668. Epub 2018 Sep 14.
Department of Neck and Thoracic Surgery, 187th Hospital of People's Liberation Army, Haikou, Hainan 571100, P.R. China.
This study retrospectively analyzed the clinical and pathological data of 1,231 patients affected by anemia after surgical treatment of hyperthyroidism to explore the influencing factors of anemia after surgical treatment of hyperthyroidism. The clinical data of 1,231 patients affected by anemia after surgical treatment of hyperthyroidism from 1987 to 2017 were analyzed. Clinical data included the surgery methods, sex, age and pathological types. Read More
Exp Ther Med 2018 Dec 19;16(6):4585-4589. Epub 2018 Sep 19.
Department of Ultrasound, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
The present study aimed to investigate the correlation between the parameters of non-contrast helical computed tomography (NCHCT) and the total energy of holmium laser lithotripsy, and establish a correlative mathematical model. From March 2016 to February 2017, 120 patients with a single urinary calculus were examined by NCHCT prior to holmium laser lithotripsy. The calculus location was confirmed, the CT value was measured and the volume of the calculus in the established three-dimensional reconstruction model was calculated. Read More
Exp Ther Med 2018 Dec 25;16(6):4546-4552. Epub 2018 Sep 25.
Department of Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Vesicoureteral reflux (VUR) is one of the most common urinary tract anomalies in children. It has been reported that VUR may be associated with reflux nephropathy. Ultrasound contrast-enhanced voiding urosonography (CeVUS) has become a routine diagnostic method for VUR in a number of European countries; however, it is not widely used in China. Read More
Endocr J 2018 Dec 13. Epub 2018 Dec 13.
Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Chikushino, Fukuoka 818-8502, Japan.
Glucose intolerance is often observed in patients with pheochromocytoma. However, it remains controversial issue that glucose intolerance on pheochromocytoma is caused by impaired insulin secretion and/or by increased insulin resistance. We aimed to reveal the mechanism of glucose intolerance on pheochromocytoma with regard to the type and amount of catecholamines released. Read More
J Clin Microbiol 2018 Dec 12. Epub 2018 Dec 12.
Centre for Nephrology, Division of Medicine, University College London, Royal Free Campus, Rowland Hill Street, London NW3 2PF, UK.
Midstream urine culture (MSU) remains the gold standard diagnostic test for confirming urinary tract infection (UTI). We previously showed that patients with chronic lower urinary tract symptoms (LUTS) below the diagnostic cut-off on MSU culture may still harbour bacterial infection, and that their antibiotic treatment was associated with symptom resolution. Here, we evaluated the results of the UK's MSU culture in symptomatic patients and controls. Read More
Drug Metab Dispos 2018 Dec 12. Epub 2018 Dec 12.
Daiichi Sankyo Co. Ltd.
Esaxerenone (CS-3150) is a novel non-steroidal selective mineralocorticoid receptor blocker. The absorption, metabolism, distribution and excretion (ADME) of esaxerenone was assessed in in vitro studies and a clinical study of [C]esaxerenone (150 μCi/20 mg) administered orally to 6 healthy male subjects. Plasma concentrations of esaxerenone and metabolites M4, M11 and M1 were measured by LC-MS/MS methods. Read More