731,723 results match your criteria Urinary Tract Infection Males


Differential exposure to organophosphate flame retardants in mother-child pairs.

Chemosphere 2018 Dec 4;219:567-573. Epub 2018 Dec 4.

Departmentof Environmental Health Sciences, Mailman School of Public Health, Columbia University, 722 W 168th St, New York, NY 10032, USA. Electronic address:

Background: Humans are ubiquitously exposed to flame retardants, including organophosphate esters (OPEs), through direct contact with consumer products or exposure through household dust. Children are at increased risk because of their proximity to dust, hand-to-mouth activity, and the importance of childhood as a critical period in neurodevelopment.

Objectives: To quantify differences in exposure levels between mothers and children (three to six years of age), we analyzed urinary metabolites of OPEs. Read More

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December 2018
2 Reads

Urinary levels of bisphenol A, F and S and markers of oxidative stress among healthy adult men: Variability and association analysis.

Environ Int 2018 Dec 12;123:301-309. Epub 2018 Dec 12.

Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China. Electronic address:

Background: Bisphenol F (BPF) and bisphenol S (BPS) are increasingly used as alternatives to endocrine disrupting chemical bisphenol A (BPA). Evidence from in vitro and animal studies demonstrates that BPA, BPF and BPS induce oxidative stress, a proposed mechanism that is relevant to various adverse health effects. Evaluation in humans is hampered by the potentially high within-subject variability of urinary measurements. Read More

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December 2018

One-carbon metabolism nutrient intake and the association between body mass index and urinary arsenic metabolites in adults in the Chihuahua cohort.

Environ Int 2018 Dec 12;123:292-300. Epub 2018 Dec 12.

Environmental Science and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Curriculum in Toxicology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Electronic address:

Background: Exposure to inorganic arsenic (iAs) via drinking water is a serious global health threat. Various factors influence susceptibility to iAs-associated health outcomes, including differences in iAs metabolism. Previous studies have shown that obesity is associated with iAs metabolism. Read More

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December 2018
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Effectiveness of Fosfomycin Tromethamine Prophylaxis in Preventing Infection Following Ultrasound-guided Prostate Needle Biopsies: Results from a Large Canadian Cohort.

J Glob Antimicrob Resist 2018 Dec 12. Epub 2018 Dec 12.

Department of Microbiology and Infectious Diseases, Université de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4; Centre de recherche du Centre hospitalier universitaire de Sherbrooke, 3001 12e avenue nord, Sherbrooke, QC, Canada J1H5N4,. Electronic address:

Background: Rates of infection following ultrasound-guided transrectal prostate needle biopsy (TRUSPB) are increasing. We aimed to evaluate the effectiveness of fosfomycin tromethamine (FMT) prophylaxis in preventing post-TRUSPB infectious complications.

Methods: This nested case-control study included patients who underwent TRUSPB in a Canadian tertiary care hospital, and developed post-TRUSPB bacteremia or urinary tract infections. Read More

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December 2018

Perineal prevention and protection in obstetrics: CNGOF Clinical Practice Guidelines.

J Gynecol Obstet Hum Reprod 2018 Dec 12. Epub 2018 Dec 12.

Obs/Gyn, Epidemiologist. INSERM CIC1402, Université de Poitiers, CHU de Poitiers, France. Electronic address:

Introduction: The objective of these clinical practice guidelines was to analyse all of the interventions during pregnancy and childbirth that might prevent obstetric anal sphincter injuries (OASIS) and postnatal pelvic floor symptoms.

Material And Methods: These guidelines were developed in accordance with the methods prescribed by the French Health Authority (HAS).

Results: A prenatal clinical examination of the perineum is recommended for women with a history of Crohn's disease, OASIS, genital mutilation, or perianal lesions (professional consensus). Read More

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December 2018
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Non-Muscle Invasive Bladder Cancer Influences Physical Health Related Quality of Life and Urinary Incontinence.

Urology 2018 Dec 12. Epub 2018 Dec 12.

University of Washington, Department of Urology. Electronic address:

Objective: To evaluate the effects of non-muscle invasive bladder cancer (NMIBC) on health-related quality of life (HRQOL) and urinary function within patients diagnosed with NMIBC as compared to the general population.

Methods: Using the Surveillance, Epidemiology, and End Results-Medicare Health Outcome Survey (SEER-MHOS) database (1998-2013), 325 patients diagnosed with NMIBC with baseline and post-diagnosis MHOS surveys were propensity-matched 1:5 to non-cancer controls (NCC). Multivariate linear regression analysis compared NMIBC patients with matched NCC in terms of physical component summary (PCS), mental component summary (MCS), and health domain scales. Read More

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December 2018

Randomized Controlled Trial of Aquablation vs. Transurethral Resection of the Prostate in Benign Prostatic Hyperplasia: One-Year Outcomes.

Urology 2018 Dec 12. Epub 2018 Dec 12.

UT Southwestern Medical Center, Department of Urology, University of Texas Southwestern, Dallas, TX, US.

Objective: To report 1-year safety and efficacy outcomes after either Aquablation or TURP for the treatment of lower urinary tract symptoms related to BPH.

Methods: This double-blinded, multicenter prospective randomized controlled trial assigned 181 patients with BPH-related moderate-to-severe lower urinary tract symptoms to either electrocautery-based prostate resection (TURP) or Aquablation. Efficacy endpoints included reduction in International Prostate Symptom Score and improvement in uroflow parameters. Read More

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December 2018

Efficacy and Safety of Non-Invasive Intravesical Instillation of Onabotulinum Toxin-A for Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome: Systematic Review and Meta-analysis.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, Seoul, South Korea. Electronic address:

Objective: To investigate the efficacy and safety of non-invasive intravesical instillation of OBTX-A through systematic review and meta-analysis. Recently, several studies of non-invasive intravesical instillation of Onabotulinum Toxin-A (OBTX-A) have been published. However, its efficacy is not well validated yet compared to well-known efficacy of minimally invasive intravesical injection of OBTX-A. Read More

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December 2018
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An Isolated Ureteropelvic Junction Injury Following a Low-Impact Mechanical Fall.

Urology 2018 Dec 12. Epub 2018 Dec 12.

University of Massachusetts Memorial Health Care.

Objective: To describe the presentation of a rare isolated ureteropelvic junction injury resulting from a mechanical fall on ice.

Materials And Methods: A 71-year-old previously healthy man presented to the emergency department at the University of Massachusetts Medical School three hours following falling on ice with complaints of gross hematuria and flank pain. Patient records were accessed via the institution's electronic medical records system between March 22, 2018 and April 22, 2018. Read More

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December 2018

A community outbreak of Legionnaires' disease in Geneva, Switzerland, June to September 2017.

Swiss Med Wkly 2018 Nov 2;148:w14687. Epub 2018 Dec 2.

Laboratory of Virology, Division of Laboratory Medicine and Division of Infectious Diseases, University of Geneva Hospitals, Switzerland; University of Geneva Medical School, Switzerland.

Purpose: Eight confirmed cases of Legionnaires’ disease were identified at the Geneva University Hospitals between 28 July 2017 and 02 August 2017, leading to a detailed outbreak investigation.

Methods: Legionnaires’ disease cases were defined according to Swiss and European (ELDSNet) consensus guidelines. An outbreak investigation task force was put in place. Read More

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November 2018

Factors influencing return for maintenance treatment with Percutaneous Tibial Nerve Stimulation for the management of the overactive bladder.

BJU Int 2018 Dec 15. Epub 2018 Dec 15.

Department of Uro-Neurology, The National Hospital for Neurology and Neurosurgery, and UCL Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom.

Objectives: To identify factors influencing return for maintenance Percutaneous tibial nerve stimulation (PTNS) treatment after successful completion of a 12-week course of treatment for the overactive bladder (OAB).

Patients And Methods: Patients with OAB symptoms referred for PTNS treatment underwent twelve sessions of weekly PTNS treatment and evaluated at baseline and week 12 using the International Consultation on Incontinence Questionnaire on OAB (ICIQ-OAB), lower urinary tract symptoms related quality of life questionnaire (ICIQ-LUT symptoms QOL) and bladder diary (BD). Responders to treatment, evaluated using two patient-reported outcome measurements, were invited to return for maintenance treatments when symptoms returned. Read More

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December 2018

Serum and Urinary Selenium Status in Patients with the Pre-diabetes and Diabetes in Northeast China.

Biol Trace Elem Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Laboratory Medicine, First Hospital of Jilin University, Changchun, 130021, China.

Homeostasis imbalance of selenium (Se) in diabetes has received great attention. This study investigated serum and urinary Se levels in patients with impaired fasting glucose (IFG), impaired glucose tolerance (IGT), type 1 diabetes (T1D), and type 2 diabetes (T2D) in Northeast Chinese populations. From January 2010 to October 2011, patients with IFG (n = 12), IGT (n = 15), T1D (n = 25), T2D (n = 137), and healthy controls (n = 50) were enrolled in the First Hospital of Jilin University. Read More

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December 2018

Radiographic stool quantification: an equivalence study of 484 symptomatic and asymptomatic subjects.

Abdom Radiol (NY) 2018 Dec 14. Epub 2018 Dec 14.

Department of Radiology, Michigan Medicine, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA.

Purpose: To determine if symptomatic patients referred for radiographic stool quantification have equivalent stool burden to asymptomatic patients.

Method: This was an IRB-approved HIPAA-compliant retrospective equivalence cohort study. An a priori equivalence power calculation was performed. Read More

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December 2018

Drug adherence and drug-related problems in pharmacotherapy for lower urinary tract symptoms related to benign prostatic hyperplasia.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Urological Outpatient Clinic, Warsaw, Poland.

Lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is one of the most common urinary disorders in elderly men. In recent years, pharmacotherapy of BPH has increased the efficacy, including combination treatment mostly with two drug classes, namely, 5-α-reductase inhibitors and α-1-adrenolytics (alpha blockers) with a different pharmacological activity. Although pharmacological treatment of BPH is a success story in urology, daily practice suggests that several medical needs remain unmet. Read More

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Urinary neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, uromodulin, and cystatin C concentrations in an experimental rat model of ascending acute kidney injury induced by pyelonephritis.

J Physiol Pharmacol 2018 Aug 9;69(4). Epub 2018 Dec 9.

Department of Pathophysiology, Jagiellonian University Medical College, Cracow, Poland.

Recent evidence suggests that neutrophil gelatinase-associated lipocalin (NGAL), kidney injury molecule-1 (KIM-1), cystatin C (CysC), uromodulin (UMOD), and some interleukins (IL-6 and IL-18) can be considered as diagnostic markers of acute kidney injury (AKI). The aim of this study was to verify the applicability of four urinary (u) markers, namely uNGAL, uKIM-1, uCysC, and uUMOD, for the diagnosis of ascending AKI induced by bacterial pyelonephritis. The study included 30 female rats that were divided into three groups (n = 10 each) and were inoculated transurethrally with various doses of Escherichia coli to induce isolated pyelonephritis (group 1, 10 CFU/ml), pyelonephritis-induced AKI (group 2, 10 CFU/ml), or AKI and urosepsis (group 3, 10 CFU/ml). Read More

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Emergency Room Safer Transfer of Patients (ER-STOP): a quality improvement initiative at a community-based hospital to improve the safety of emergency room patient handovers.

BMJ Open 2018 Dec 14;8(12):e019553. Epub 2018 Dec 14.

Department of Medicine, Division of Respirology, University of Toronto and Michael Garron Hospital, Michael Garron Hospital, Toronto, Ontario, Canada.

Objectives: Ensure early identification and timely management of patient deterioration as essential components of safe effective healthcare. Prompted by analyses of incident reports and deterioration events, a multicomponent organisational rescue from danger system was redesigned to decrease unexpected inpatient deterioration.

Design: Quality improvement before-after unblinded trial. Read More

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December 2018

Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats.

Biomed Pharmacother 2019 Jan 5;109:910-920. Epub 2018 Nov 5.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.

Early detection and clinical interference are major challenges for the prevention of diabetic nephropathy (DN) progression. This study investigated the effects of dapagliflozin, a sodium glucose co-transporter 2 inhibitor, on some early markers for DN in fructose-streptozotocin (Fr-STZ)-induced diabetes in rats. Fr-STZ rats were treated with either dapagliflozin (1 mg/kg p. Read More

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January 2019
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Zengye decoction induces alterations to metabolically active gut microbiota in aged constipated rats.

Biomed Pharmacother 2019 Jan 12;109:1361-1371. Epub 2018 Nov 12.

School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Guangzhou, 510006, PR China; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China. Electronic address:

Zengye decoction (ZYD), a traditional Chinese medicinal formula, has been used in the treatment of various chronic diseases, such as constipation and skin dryness syndrome. Clinically, the specific mechanisms and targets of ZYD for treating disease remain unclear. The present study was undertaken to investigate the effects of ZYD on the gut microbiota and host metabolites in aged constipated rats and the relationship between the intestinal microbiota and the host. Read More

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January 2019
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Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study.

Am J Perinatol 2018 Dec 14. Epub 2018 Dec 14.

Research Center, CHU Sainte-Justine, Mother and Child University Hospital Center, Montreal, Quebec, Canada.

Background:  Little is known about the association between bisphenol A (BPA) or triclosan (TCS) exposure and hypertension in pregnancy.

Objective:  To investigate potential associations between maternal urinary concentrations of BPA or TCS and gestational hypertension (GH) and preeclampsia.

Study Design:  Among 1,909 pregnant women participating in the maternal-infant research on environmental chemicals (MIREC) study, urinary concentrations of BPA and TCS were measured in the first trimester by liquid chromatography-tandem mass spectrometry using isotope dilution. Read More

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December 2018
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Uromodulin in a pathway between decreased renal urate excretion and albuminuria.

Am J Hypertens 2018 Dec 14. Epub 2018 Dec 14.

Centre de recherche du CHUM, Montréal, Quebec, Canada.

Background: The mechanism explaining the inverse association between renal urate and albumin excretion remains unclear. First, we evaluated the impact of candidate variants in the main urate transporter genes (i.e. Read More

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December 2018
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Aerobic Exercise Training Alleviates Renal Injury by Interfering with Mitochondrial Function in Type-1 Diabetic Mice.

Med Sci Monit 2018 Dec 14;24:9081-9089. Epub 2018 Dec 14.

Department of Sports, Shanghai University of Traditional Chinese Medicine, Shanghai, China (mainland).

BACKGROUND Diabetic nephropathy was one of the most serious and harmful diabetic complications, characterized by progressive loss of renal function and renal fibrosis. Aerobic exercise training is an important non-pharmacologic method to prevent and treat diabetes mellitus and diabetic complications. MATERIAL AND METHODS Intraperitoneal (i. Read More

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December 2018

3D simulation of solutes concentration in urinary concentration mechanism in rat renal medulla.

Math Biosci 2018 Dec 11. Epub 2018 Dec 11.

Division of General Internal Medicine, Department of Medicine, Toronto General Hospital, Toronto.

In this work, a mathematical model was developed to simulate the urinary concentration mechanism. A 3-D geometry was derived based on the detail physiological pictures of rat kidney. The approximate region of each tubule was obtained from the volume distribution of structures based on Walter Pfaller's monograph and Layton's region-based model. Read More

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December 2018

Dusting, fragmenting, popcorning or dustmenting?

Curr Opin Urol 2018 Dec 12. Epub 2018 Dec 12.

Klinik und Poliklinik für Urologie, Universitätsklinikum Köln, Köln, Germany.

Purpose Of Review: The present review identifies the latest scientific investigations within the fields of fragmenting and dusting to discuss optimizing treatment. In addition, new settings such as 'popcorning' are scrutinized carefully.

Recent Findings: During the past years, endoscopic techniques have continuously developed and changed the management of the treatment of kidney stones using ureteroscopy (URS). Read More

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December 2018

Microbiology and Drug Resistance of Pathogens in Patients Hospitalized at the Nephrology Department in the South of Poland.

Pol J Microbiol 2018 ;67(4):517-524

Chair and Department of Nephrology, Jagiellonian University , Cracow , Poland.

A retrospective study was conducted among 498 patients with urinary tract infections (UTI) referred to our department from January 2013 to December 2015. This study was performed to evaluate the etiology of UTI and the antibiotic susceptibility profile of Escherichia coli ( E. coli ) as the main etiological factor in different age groups. Read More

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January 2018

Primary and Secondary Bacteremia Caused by spp.: Epidemiology, Strains Susceptibility and Biofilm Formation.

Pol J Microbiol 2018 ;67(4):471-478

Department of Microbiology, Nicolaus Copernicus University in Toruń, L. Rydygier Collegium Medicum in Bydgoszcz , Poland.

Proteus spp. is an etiological factor of urinary tract and bloodstream infections. The aim of this study was the retrospective analysis of susceptibility of Proteus spp. Read More

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January 2018

[PHYSICAL, CHEMICAL AND MORPHOLOGICAL URINE EXAMINATION: RECOMMENDATIONS FOR THE POST ANALYTICAL PHASE FROM THE INTERDISCIPLINARY URINALYSIS GROUP (GIAU)].

G Ital Nefrol 2018 Dec;35(6)

Cattedra Nefrologia Università degli Studi di Bari-Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari.

With these recommendations the Interdisciplinary Urinalysis Group (GIAU) aims to stimulate the following aspects : improvement and standardization of the post analytical approach to physical, chemical and morphological urine examination (ECMU); emphasize the value added to ECMU by selection of clinically significant parameters, indication of analytical methods, of units of measurement, of reference values; improvement of interpretation of dip stick urinalysis with particular regard to the reconsideration of the diagnostic significance of the evaluated parameters together with an increasing awareness of the limits of sensitivity and specificity of this analytical method. Accompanied by the skills to propose and carry out in-depth investigations with analytical methods that are more sensitive and specific;increase the awareness of the importance of professional skills in the field of urinary morphology and their relationships with the clinicians. through the introduction, in the report, of descriptive and interpretative comments depending on the type of request, the complexity of the laboratory, the competence of the pathologist;implement a policy of evaluation of the analytical quality by using, in addition to traditional internal and external controls, a program for the evaluation of morphological competence. Read More

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December 2018

Estimated Total Albumin in Fresh Urine Samples Based on Correlation Between the Roche Immunoturbidimetric and an In-House HPLC Method.

Clin Lab 2018 Oct;64(11)

Background: Many studies have reported higher values of urinary albumin measured by high performance liquid chromatography (HPLC) in comparison with immunochemical methods. The aims of our study were the implementation of the HPLC method for albuminuria, testing the hypothesis about coeluting proteins, comparison of albuminuria assessed by HPLC and immunoturbidimetric (IT) methods in diabetic and non-diabetic patient samples. Methods: We compared albuminuria assessed by HPLC with albuminuria assessed by the IT method in fresh urine samples of 636 diabetics and 456 non-diabetics. Read More

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October 2018

Urinary circulating DNA and circulating antigen for diagnosis of schistosomiasis mansoni: a field study.

Trop Med Int Health 2018 Dec 14. Epub 2018 Dec 14.

Medical Biochemistry Department, Faculty of Medicine, University of Alexandria, Egypt.

Objective: To evaluate three non- invasive assays for the diagnosis of schistosomiasis mansoni in an Egyptian village.

Methods: Urine was collected for the detection of circulating cathodic antigen (CCA) and cell free parasite DNA (cfpd) by Point-of-contact (POC)-cassette assay and PCR respectively. These tests were compared to Kato Katz (KK) fecal thick smear for detection of Schistosoma mansoni eggs. Read More

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December 2018

The vaginal distention model in mice is not a reliable model of simulated birth trauma-induced stress urinary incontinence.

Neurourol Urodyn 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio.

Aims: Vaginal distention (VD) is a validated model of birth-related trauma in rats. Recently a mouse VD model was reported. Our study was originally conducted to evaluate the impact of age on VD in mice. Read More

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December 2018

MicroRNA-101 protects bladder of BOO from hypoxia-induced fibrosis by attenuating TGF-β-smad2/3 signaling.

IUBMB Life 2018 Dec 13. Epub 2018 Dec 13.

Department of Urology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Bladder outlet obstruction is a common disease, which always evokes urinary bladder wall remodeling significantly. It has been suggested that bladder outlet obstruction can make the bladder progression from inflammation to fibrosis, and hypoxia may play a vital role. It has been found the expression of microRNA-101 varied in bladder after BOO. Read More

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December 2018

New treatment method for mucopolysaccharidosis type VI by liver transplantation.

Pediatr Int 2018 Dec 13. Epub 2018 Dec 13.

Department of Clinical Diagnosis, National Center for Child Health and Development, Tokyo.

Background: Mucopolysaccharidosis (MPS) VI is a rare, autosomal recessive congenital metabolic disorder caused by deficient activity of the lysosomal metabolic enzyme, N-acetylgalactosamine 4-sulfatase. Enzyme replacement therapy (ERT) is current therapeutic treatment for MPS VI, while involves limited compliance to the therapy and high costs. This study aimed to develop a new method of treatment by conducting an orthotopic liver transplantation using an animal model of human MPS VI, and to evaluate and examine its effectiveness for treating MPS VI. Read More

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December 2018

Male patients with a higher frequency of nocturnal urinary episodes are more likely to benefit from alpha-blocker therapy for bothersome nocturia.

Low Urin Tract Symptoms 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan.

Objective: This retrospective study investigated the therapeutic effects of alpha-blockers on men with lower urinary tract symptoms (LUTS) to identify baseline variables that may predict therapeutic response in terms of nocturia improvement.

Methods: The study included 348 men with LUTS, including bothersome nocturia, treated with tamsulosin 0.4 mg at bedtime (h. Read More

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December 2018

Is obstructive sleep apnea syndrome related to nocturia?

Low Urin Tract Symptoms 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Istanbul Taksim Gaziosmanpasa Training and Research Hospital, Istanbul, Turkey.

Objective: The aim of this study was to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH).

Methods: This multicenter study was performed on 122 male patients with dyspnea and/or sleep disorder. Patient characteristics were recorded. Read More

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December 2018
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Urinary concentrations of AICAR and mannitol in athlete population.

Drug Test Anal 2018 Dec 12. Epub 2018 Dec 12.

UCLA Olympic Analytical Laboratory, Department of Pathology & Laboratory Medicine, Geffen School of Medicine, Los Angeles, California, USA.

Both AICAR and mannitol are prohibited for use in sports, but no decisive criteria that would guide anti-doping laboratories on data interpretation have been established so far. In an attempt to help harmonize reporting and management of analytical findings, reference population data collected for the US athletes are presented. Upon analysis of 12377 samples, mean urinary AICAR concentration was found to be 647 ± 365 ng/mL with median value of 574 ng/mL, 99 percentile at 1786 ng/mL and 99. Read More

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December 2018

Pelvic magnetic resonance imaging parameters predict urinary incontinence after robot-assisted radical prostatectomy.

Low Urin Tract Symptoms 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Objective: Urinary incontinence (UI) is a major prostate cancer (PCa) treatment-related morbidity. It has been reported that post-prostatectomy UI is related to the width of the pelvic floor muscles (PFM) and the length of the urethra. However, the details of these anatomical parameters are unknown. Read More

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December 2018

Proteomic Evidence of Biological Ageing in a Child with a Compound Heterozygous ZMPSTE24 Mutation.

Proteomics Clin Appl 2018 Dec 13:e1800135. Epub 2018 Dec 13.

A. K. Lucas-Herald, B. Mansoorian, W. Mullen, C. Delles, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, G12 8TA, UK.

Background: Progeria-like syndromes offer a unique insight into ageing. Here we present the case of a boy affected with mandibuloacral dysplasia and compound heterozygous mutations in ZMPSTE24.

Methods: Capillary electrophoresis-mass spectroscopy was used for proteome analysis to analyse peptides previously found to be differentially regulated in chronic kidney disease (273 peptides defining the CKD273 classifier), coronary artery disease (238 peptides defining the CAD238 classifier) and ageing (116 peptides defining the AGE116 classifier). Read More

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December 2018

Long-term safety and efficacy of antimuscarinic add-on therapy in patients with overactive bladder who had a suboptimal response to mirabegron monotherapy: A multicenter, randomized study in Japan (MILAI II study).

Int J Urol 2018 Dec 13. Epub 2018 Dec 13.

Astellas Pharma Inc., Tokyo, Japan.

Objectives: To evaluate the long-term safety (primary objective) and efficacy (secondary objective) of antimuscarinic add-on therapy in patients receiving mirabegron.

Methods: During a 2-week screening period, patients (aged ≥20 years, mirabegron treatment for ≥6 weeks, residual overactive bladder symptoms) received mirabegron 50 mg once daily. These patients were subsequently randomized to 52 weeks' treatment with mirabegron 50 mg/day plus an antimuscarinic (solifenacin 5 mg, propiverine 20 mg, imidafenacin 0. Read More

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December 2018
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Identification of new urinary gamma-hydroxybutyric acid (GHB) markers applying untargeted metabolomics analysis following placebo-controlled administration to humans.

Drug Test Anal 2018 Dec 12. Epub 2018 Dec 12.

Department of Forensic Pharmacology & Toxicology, Zurich Institute of Forensic Medicine, University of Zurich, Zürich, Switzerland.

Gamma-hydroxybutyrate (GHB) is a short-chain fatty acid that occurs naturally in the mammalian brain and that is prescribed as a medication against narcolepsy or used as a drug of abuse. Particularly, its use as a knock-out drug in cases of drug facilitated crimes is of major importance in forensic toxicology. Because of its rapid metabolism and resulting narrow detection windows (<12 h in urine), detection of GHB remains challenging. Read More

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December 2018

Impaired Vascular Function in Exercising Anovulatory Premenopausal Women is Associated with Low Bone Mineral Density.

Scand J Med Sci Sports 2018 Dec 12. Epub 2018 Dec 12.

Penn State University, Department of Kinesiology, University Park, Pennsylvania, United States.

In estrogen deficient postmenopausal women, osteoporosis shares a common link with cardiovascular disease risk, including endothelial dysfunction. The current study sought to examine associations between bone mineral density (BMD) and endothelial function in estrogen deficient premenopausal women with exercise-associated menstrual disturbances. Recreationally trained women (24. Read More

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December 2018
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Immediate versus delayed removal of urinary catheter after laparoscopic hysterectomy: a randomized-controlled trial.

BJOG 2018 Dec 12. Epub 2018 Dec 12.

Department of Gynaecology, Leids Universitair Medisch Centrum, Leiden, the Netherlands.

Objective: To evaluate if immediate catheter removal (ICR) after laparoscopic hysterectomy is associated with similar retention outcomes compared to delayed removal (DCR).

Study Design: Non-inferiority randomized controlled trial.

Population: Patients undergoing laparoscopic hysterectomy in six hospitals in the Netherlands. Read More

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December 2018

The assessment, incidence and factors associated with urinary incontinence in older Aboriginal Australians.

Intern Med J 2018 Dec 11. Epub 2018 Dec 11.

Aged Care, Melbourne Health and University of Melbourne, Melbourne, Australia.

Background: Little is known about urinary incontinence in older Aboriginal Australians.

Aim: To describe urinary incontinence assessment, prevalence, incidence, and associated conditions in older Aboriginal Australians.

Methods: Wave 1 consisted of 363 Aboriginal participants aged ≥45 years from Western Australia. Read More

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December 2018

Isotopically labeled boldenone as a better marker of derivatization efficiency for improved quality control in anti-doping analysis.

Drug Test Anal 2018 Dec 9. Epub 2018 Dec 9.

UCLA Olympic Analytical Laboratory, Department of Pathology & Laboratory Medicine, Geffen School of Medicine, Los Angeles, California, USA.

At present, anti-doping laboratories use androsterone, a major urinary steroid metabolite, to evaluate completeness of the derivatization step. This is typically done by calculating the ratio of mono-trimethylsilyl (TMS) androsterone to the total mono- and di-TMS androsterone. Certain samples may show an elevated percentage of mono-TMS androsterone indicating a failed derivatization step. Read More

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December 2018

In utero myelomeningocele repair and urological outcome: the first 100 cases of a prospective analysis. Is there an improvement in bladder function?

BJU Int 2018 Dec 9. Epub 2018 Dec 9.

Department of Urology, CACAU-NUPEP, São Paulo, Brazil.

Objectives: To evaluate the first one hundred cases of in utero myelomeningocele repair and urological outcome in a prospective analysis aiming to define possible improvement in bladder function.

Patients And Methods: We used a protocol consisting of detailed medical history, urinary tract ultrasound (US), voiding cystourethrography (VCUG) and urodynamic evaluation (UE). Patients were categorized into 4 patterns, including: normal, high risk (overactive bladder with detrusor leak point pressure higher than 40 cm H2O and high filling pressures also above 40 cm H2O), incontinent and underactivity (underactive bladder with post-void residual urine) and patients were treated accordingly. Read More

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December 2018

Laparoscopic artificial urinary sphincter implantation in women with stress urinary incontinence: update on 13 years experience in a single center.

BJU Int 2018 Dec 11. Epub 2018 Dec 11.

Clinique du Pré, Dept of Urology, Technopôle Université, 13 Avenue René Laennec, 72018, Le Mans, France.

Introduction: Stress urinary incontinence (SUI) mainly affects women as a result of pregnancies with laborious delivery, obesity, and pelvic floor dysfunctions. The first therapeutic approach includes life-style interventions, pelvic floor muscle or bladder training. The second-line treatment usually is surgical. Read More

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December 2018

MMP-2 and MMP-9 as prognostic markers for the early detection of urinary bladder cancer.

J Biochem Mol Toxicol 2018 Dec 10:e22275. Epub 2018 Dec 10.

Department of Biochemistry Sciences, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.

The present study assessed protein and gene expression levels of tissue inhibitor of metalloproteinase-2 (TIMP-2), matrix metalloproteinase-2 (MMP-2), and MMP-9 in urine and blood samples of 50 patients with bladder carcinoma. The expression of TIMP-2, MMP-2, and MMP-9 levels with tumor stage and grade was also assessed. Results showed that the expression levels of MMP-2 and MMP-9 in both blood and urine were significantly elevated in group 1 when compared with groups 2 and 3 healthy subjects. Read More

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December 2018

Pattern of urine iodine excretion with low iodine diet during preparation for radioactive iodine ablation in patients with thyroid cancer.

Head Neck 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea.

Background: The optimal period of low iodine diet during preparation for radioactive iodine (RAI) ablation in an area with iodine-rich diet was investigated.

Methods: Ninety-four patients with thyroid cancer who underwent low iodine diet and RAI were prospectively allocated into 2 groups-thyroxine withdrawal or using recombinant human thyroid stimulating hormone (rhTSH) for TSH stimulation. Their urinary iodine excretion (UIE) patterns were analyzed. Read More

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December 2018

Low dose CT scan in stone detection for stone treatment follow up: is there a relation between stone composition and radiation delivery? Study on a porcine-kidney model.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Università degli Studi di Milano, Milan, Italy.

Background: Non-contrast CT scan (NCCT) is becoming the standard imaging modality in urinary stone disease. Radiation dose remains an issue, especially for those patients who may need to undergo several CT scans for this indication during their lifetime. Low-dose and ultra-low-dose protocols exist, but there is limited data on the relationship between the minimum radiation dose capable of detecting stone fragments and stone composition. Read More

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December 2018

Effect of puboprostatic ligament reconstruction on continence recovery after robot-assisted laparoscopic prostatectomy: our initial experience.

Minerva Urol Nefrol 2018 Dec 14. Epub 2018 Dec 14.

Department of Urology, Ospedale Policlinico e Nuovo Ospedale Civile S.Agostino Estense, University of Modena and Reggio Emilia, Modena, Italy.

Background: Prostate cancer represents a serious health problem worldwide. Radical prostatectomy is the gold standard for management of localized prostate cancer. Urinary incontinence is among the most common complications affecting RALP patients' post-operative quality of life. Read More

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December 2018

Increased AURKA promotes cell proliferation and predicts poor prognosis in bladder cancer.

BMC Syst Biol 2018 Dec 14;12(Suppl 7):118. Epub 2018 Dec 14.

National Medical Centre of Colorectal Disease, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210001, China.

Background: Bladder cancer (BC) is the most common cancer of the urinary bladder and upper tract, in which the clinical management is limited. AURKA (aurora kinase A) has been identified as an oncogene in cancer development; however, its potential role and underlying mechanisms in the progression of BC remain unknown.

Results: In this study, we evaluated Aurora kinase A (AURKA) expression in patient samples by performing gene expression profiling, and found that AURKA expression levels were significantly higher in BC tissues than in normal tissues. Read More

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December 2018
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Analysis of the differential urinary protein profile in IgA nephropathy patients of Uygur ethnicity.

BMC Nephrol 2018 Dec 14;19(1):358. Epub 2018 Dec 14.

Nephrology department, The Xinjiang Uygur Autonomous Region People's Hospital, 91 Tianchi Road, Urumqi, Xinjiang, China.

Background: IgA nephropathy (IgAN) is one of the most common forms of idiopathic glomerular diseases and might lead to end-stage kidney disease. Accurate and non-invasive biomarkers for early diagnosis are required for early intervention and consequent therapy for IgAN patients. Because variance in the disease incidence and predisposing genes of IgAN has been detected among different ethnicities, the ethnicity factor should be considered in IgAN biomarker discovery. Read More

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December 2018
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