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Biology (Basel) 2022 Jun 9;11(6). Epub 2022 Jun 9.

Department of Anatomy, Cell Biology and Physiological Sciences, Faculty of Medicine, American University of Beirut, Beirut P.O. Box 11-0236, Lebanon.

Previous studies have suggested a link between urinary tract infections (UTIs) and cognitive impairment. One possible contributing factor for UTI-induced cognitive changes that has not yet been investigated is a potential alteration in hippocampal neurogenesis. In this study, we aim to investigate the effect of UTI on brain plasticity by specifically examining alterations in neurogenesis. Read More

Antibiotics (Basel) 2022 Jun 3;11(6). Epub 2022 Jun 3.

Department of Biology & CESAM, University of Aveiro, 3810-193 Aveiro, Portugal.

Urinary tract infections (UTIs) are one of the most common infectious diseases at the community level. The continue misuse of antimicrobials is leading to an increase in bacterial resistance, which is a worldwide problem. The objective of this work was to study the incidence and pattern of antimicrobial resistance of the main bacteria responsible for UTI in the community of central and northern Portugal, and establish an appropriate empirical treatment. Read More

Antibiotics (Basel) 2022 May 24;11(6). Epub 2022 May 24.

Servicio de Medicina Interna, Hospital San Juan de la Cruz, 23400 Úbeda, Spain.

Community-onset bloodstream infections (CO-BSI) caused by gram-negative bacilli are common and associated with significant mortality; those caused by are associated with worse prognosis and higher rates of inadequateempirical antibiotic treatment. The aims of this study were to describe the characteristics of patients with CO-BSI caused by , to identify predictors, and to develop a predictive score for CO-BSI.

Materials/methods: PROBAC is a prospective cohort including patients >14 years with BSI from 26 Spanish hospitals between October 2016 and May 2017. Read More

Andes Pediatr 2022 Apr;93(2):222-228

Hospital Roberto del Río, Santiago, Chile.

Kidney abscess is an unusual entity in childhood with few studies about its clinical characteris tics.

Objective: To report the clinical presentation, diagnosis, and therapy used in a cohort of 20 children with kidney abscess.

Patients And Method: retrospective study of cases of kidney abscess during a 10-year period at the Hospital Roberto del Río. Read More

Am J Case Rep 2022 Jun 22;23:e936058. Epub 2022 Jun 22.

Department of Emergency Medicine, Yamato Tokushukai Hospital, Yamato, Kanagawa, Japan.

BACKGROUND Vertebral osteomyelitis is a rare form of bone infection that requires prompt diagnosis and treatment; however, this is challenging because of the lack of specific symptoms and low sensitivity of diagnostic tests, especially in the early stages. Our case demonstrates the challenges in diagnosing vertebral osteomyelitis and provides relevant information for other physicians dealing with possible cases of vertebral osteomyelitis. CASE REPORT An 83-year-old man presented to the Emergency Department with severe low back pain of 2 weeks' duration. Read More

Future Microbiol 2022 Jun 15. Epub 2022 Jun 15.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, 124001, India.

Diagnosis of urogenital tuberculosis (UGTB) is difficult and there is an immediate need to develop a reliable diagnostic test. A real-time immuno-PCR (RT-I-PCR) was developed to identify a cocktail of MPT-64 + ESAT-6 in both male/female UGTB patients comprising five confirmed cases, 40 clinically suspected cases and 37 non-TB controls, from whom mid-stream urine specimens were collected, while endometrial biopsies of female patients were obtained on day 1 of their menstrual cycle. Results obtained by RT-I-PCR were compared with I-PCR/ELISA and GeneXpert. Read More

J Assoc Physicians India 2022 Jun;70(6):11-12

MGM Medical College and Hospital, Aurangabad, Maharashtra, India.

Background: There are a handful of sodium glucose co-transporter 2 (SGLT2) inhibitors available in the global and Indian markets to manage type II diabetes mellitus (T2DM). However, head-to-head comparison between different SGLT2 inhibitors is scarce. Therefore, the present study was aimed to analyze the effect of different SGLT2 inhibitors on glycemic control and body weight in Indian patients with T2DM. Read More

Antimicrob Resist Infect Control 2022 Jun 14;11(1):84. Epub 2022 Jun 14.

MedStar Health, Washington, DC, USA.

Background: Uncomplicated urinary tract infections (uUTIs) are one of the most common bacterial infections in the United States (US). Contemporary data are important for understanding the health economic impact of antimicrobial-resistant uUTIs. We compared the economic burden among patients with uUTI isolates susceptible or not-susceptible to the initial antibiotic prescription. Read More

BMC Infect Dis 2022 Jun 13;22(1):542. Epub 2022 Jun 13.

Department of Medicine, King Abdulaziz Medical City, Jeddah, Saudi Arabia.

Background: The burden of carbapenem resistance is not well studied in the Middle East. We aimed to describe the molecular epidemiology and outcome of carbapenem-resistant Enterobacterales (CRE) infections from several Saudi Arabian Centers.

Methods: This is a multicenter prospective cohort study conducted over a 28-month period. Read More

Clin Spine Surg 2022 Jun 7. Epub 2022 Jun 7.

Northwell Health Long Island Jewish Medical Center, Queens, NY.

Study Design: Retrospective cohort study.

Objective: The aim of this study was to compare the relative value units (RVUs) and 30-day outcomes between primary and revision pediatric spinal deformity (PSD) surgery.

Summary Of Background Data: PSD surgery is frequently complicated by the need for reoperation. Read More

J Pediatr Urol 2022 May 29. Epub 2022 May 29.

Department of Urology, University of Virginia, Charlottesville, VA, USA. Electronic address:

Background/objective: While there is significant data on the natural history and outcomes for prenatal hydronephrosis in simplex kidneys, duplex kidneys tend to be less studied. Management can be quite variable based on provider preference. We aimed to describe practice patterns from several tertiary academic institutions, identify clinical predictors for surgical intervention and urinary tract infection (UTI) for upper pole pathology, and demonstrate the natural history of lower pole vesicoureteral reflux (VUR). Read More

Int J Clin Pract 2022 30;2022:6807203. Epub 2022 Mar 30.

Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Background: Urolithiasis is common worldwide and can predispose to urinary tract infections and renal failure. We aimed to explore the global, regional, and national burden of urolithiasis between 1990 and 2019, stratified by sex, age, and sociodemographic index (SDI).

Methods: From 1990 to 2019, data on the number of incident cases of urolithiasis, associated deaths, and disability-adjusted life years (DALYs) were extracted from the 2019 Global Burden of Disease (GBD) study. Read More

J Clin Med 2022 Jun 2;11(11). Epub 2022 Jun 2.

Infectious Disease Department, Bellvitge University Hospital-IDIBELL, University of Barcelona, 08907 Barcelona, Spain.

Acute graft pyelonephritis (AGP) is the leading cause of bloodstream infection in kidney transplant (KT) recipients. The prevalence of urinary tract infections caused by multidrug-resistant (MDR) Gram-negative bacilli is increasing. This 14-year prospective observational study sought to determine the clinical characteristics, risk factors, and outcomes of AGP with bacteremia due to MDR Gram-negative bacilli. Read More

Cureus 2022 May 7;14(5):e24796. Epub 2022 May 7.

Microbiology, All India Institute of Medical Sciences, Deoghar, Deoghar, IND.

Background: Urinary tract infection (UTI) is among the most common infections occurring during childhood. It is caused by both gram-negative and gram-positive bacteria and  is the most common causative agent.

Methods: Data of all pediatric patients in the age group of 6 months to 18 years with urinary tract infection were taken for analysis. Read More

BMJ Case Rep 2022 Jun 8;15(6). Epub 2022 Jun 8.

Urology, Lister Hospital, East and North Hertfordshire NHS Trust, Stevenage, UK.

A man in his 80s presented to the emergency department with a 5-week history of lower abdominal and groin pain which had substantially affected his mobility. He practised intermittent self-catheterisation following radiotherapy for prostate cancer. Multiple suggestive features led to initial treatment for a urinary tract infection (UTI). Read More

BMC Urol 2022 Jun 6;22(1):82. Epub 2022 Jun 6.

Department of Urology, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei, 230032, China.

Background: Although hepatitis B virus (HBV) is a recognized risk factor for renal diseases, little is known about HBV infection in individuals with upper urinary calculi (UUC). We investigated the relationship between chronic HBV infection and UUC.

Methods: We retrospectively analysed data from 1399 patients who were discharged from the Department of Urology (2017-2018). Read More

Int J Surg Case Rep 2022 May 6;94:107170. Epub 2022 May 6.

Department of Urology, Cibabat Regional General Hospital, Cimahi, West Java, Indonesia.

Introduction And Importance: Giant bladder stone is a rare entity in the modern urological practice. There have been limited reports on giant bladder stone with concomitant renal failure and bladder cancer available in the literature.

Case Presentation: A 43-year-old male patient presented to the ER with chronic gross hematuria, dysuria, intermittent urination, and bilateral flank pain. Read More

Indian J Crit Care Med 2022 ;26(4):446-451

Department of Critical Care, Mahatma Gandhi Medical College and Hospital, Jaipur, Rajasthan, India.

Background: The genus , earlier considered a rare pathogen, is now increasingly recognized as a notorious opportunistic pathogen capable of causing serious nosocomial infections, mainly urinary tract infections (UTIs). Treating these infections is an onerous task given the resistance seen in clinical strains to many currently available antimicrobials. The objective of the present study is to provide an overall view into the prevalence of spp. Read More

Adv Exp Med Biol 2022 ;1358:115-140

American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.

Male infertility is considered as a multifactorial complex reproductive illness, and male urogenital infection and inflammation are crucial etiologies contributing up to 35% of all cases. Mostly triggered by sexually transmitted diseases and uropathogens, chronic manifestation of such infection may cause irreversible infertility in the male. Male urogenital infection involves bacterial, viral, protozoal, and fungal infections many of which remain asymptomatic most of the time and are passed to the sexual partner leading to fertilization failure, pregnancy loss, and even development of illness in the offspring. Read More

BJU Int 2022 06;129(6):659-660

JAMA Netw Open 2022 May 2;5(5):e2214268. Epub 2022 May 2.

Department of Epidemiology and Public Health, University of Maryland, Baltimore.

Importance: Antibiotic treatment for asymptomatic bacteriuria is not recommended in guidelines but is a major driver of inappropriate antibiotic use.

Objective: To evaluate whether clinician culture and personality traits are associated with a predisposition toward inappropriate prescribing.

Design, Setting, And Participants: This survey study involved secondary analysis of a previously completed survey. Read More

Exp Clin Transplant 2022 05;20(5):480-486

From the Department of Nephrology, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, India.

Objectives: Polyclonal antithymocyte globulins are widely used in the induction regimens of solid-organ transplant recipients; however, their doses and outcomes remain to be standardized in Indian patients. We report our clinical experience from the real-world use of Grafalon (an anti-T-lymphocyte globulin; ATG-Fresenius) as an induction agentin renal transplant recipients from India.

Materials And Methods: In this retrospective, single- center, observational study, we analyzed the medical records of 177 consecutive, kidney-only transplant recipients who received induction therapy with Grafalon from September 2016 to March 2018 at our center. Read More

Turk J Pediatr 2022 ;64(2):265-273

Division of Pediatric Nephrology, University of Health Sciences, İzmir Tepecik Training and Research Hospital İzmir.

Background: We aimed to evaluate the predictability of extended-spectrum beta-lactamase (ESBL)-producing bacteria (PB) with inflammation markers and hemogram parameters as neutrophil-lymphocyte-ratio (NLR), platelets-lymphocyte-ratio (PLR) and mean-platelet-volume (MPV) in infants with febrile urinary tract infection until the urine cultures are resulted.

Methods: Infants between 2-24 months hospitalized for the first febrile urinary tract infections were grouped as those infected with ESBL-PB and non-ESBL-PB. The demographic and laboratory data (inflammation markers and hemogram parameters) and the ultrasonographical findings were compared between the two groups. Read More

Int Urol Nephrol 2022 May 24. Epub 2022 May 24.

Department of Urology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, 707, Section 3, Chung-Yang Road, Hualien, Taiwan.

Purpose: Neurogenic lower urinary tract dysfunction (NLUTD) is common among children with myelomeningocele (MMC). If NLUTD is not appropriately managed, recurrent urinary tract infection (UTI) can persist and may affect upper urinary tract function. This study investigated the usefulness of videourodynamic study (VUDS) in the urological management of MMC. Read More

J Obstet Gynaecol Can 2022 May 17. Epub 2022 May 17.

Maternal-infant Care Research Center (MiCare), Mount Sinai Hospital, 600 University Avenue, Room 19-231M, Toronto, Ontario, Canada M5G 1X5.

Objective: To identify determinants of cesarean delivery (CD) and examine associations between mode of delivery (MOD) and maternal and perinatal outcomes.

Methods: We conducted a retrospective analysis of a Canadian multicentre birth cohort derived from provincial data collected in 2008/2009. Maternal and perinatal characteristics and outcomes were compared between vaginal and cesarean birth and between the following MOD subgroups: spontaneous vaginal delivery (VD), assisted VD, planned cesarean delivery (CD), and intrapartum CD. Read More

Int J Surg Case Rep 2022 Jun 16;95:107201. Epub 2022 May 16.

Department of Pathology, Fattouma Bourguiba University Hospital, Monastir 5000, Tunisia; Faculty of Medicine, University of Monastir, Monastir 5000, Tunisia.

Introduction And Importance: Splenic cysts are infrequent and most of them are related to parasitic diseases. Splenic epithelial cyst (SEC) is the most common type of primary non-parasitic splenic cysts. Its pathogenesis is not yet clear. Read More

BMC Infect Dis 2022 May 19;22(1):478. Epub 2022 May 19.

Department of Infectious Diseases, Vestfold Hospital Trust, Postbox 2168, 3103, Tønsberg, Norway.

Background: The role of oral beta-lactam antibiotics in treating febrile urinary tract infections (UTI) is not yet definite. Today, fluoroquinolones together with trimethoprim-sulfamethoxazole (TMP-MTX) are considered standard of care and often the only available evidence-based oral treatment for febrile UTI. This study clarifies the efficacy and safety of pivmecillinam (PIV) used as step-down therapy for bacteremic urinary tract infection (UTI). Read More

Rev Assoc Med Bras (1992) 2022 May;68(5):559-567

Universidade Federal de Mato Grosso, Programa de Pós-Graduação em Educação Física - Cuiabá (MT), Brazil.

Objective: Few studies on physical medicine and rehabilitation analyze the benefit of wheelchair basketball in people with motor disabilities. Given these, this study aimed to investigate the effect of the intervention of wheelchair basketball on urinary tract infection in people with motor disabilities.

Methods: A 12-month experimental follow-up was conducted in a single-center study. Read More

Pediatr Ann 2022 May 1;51(5):e175-e177. Epub 2022 May 1.

Urinary tract infection (UTI) is a common diagnosis that brings children to seek medical care. It is the second most common bacterial infection in children after otitis media. However, diagnosing UTIs can be challenging, particularly in younger children, given that the symptoms may be nonspecific and it may be logistically difficult to obtain an appropriate urine sample. Read More

Case Rep Urol 2022 4;2022:5321613. Epub 2022 May 4.

Geisinger, Urology Associate, 1000 E. Mountain Boulevard, Wilkes-Barre, PA 18702, USA.

Background: Upper tract urothelial carcinoma remains an uncommon disease that is clinically difficult to identify early and surveil. Open nephroureterectomy is the gold standard for patients with high-grade disease, especially for patients in whom surveillance is complicated such as those with prior cystectomies/ileal conduits. This report presents a case of a patient with a history of radical cystectomy and ileal conduit construction who underwent a successful minimally invasive robotic surgery for treatment of upper tract urothelial carcinoma. Read More