6,579 results match your criteria Uric Acid Nephropathy


Formulation, Optimization, and Evaluation of Allopurinol-Loaded Bovine Serum Albumin Nanoparticles for Targeting Kidney in Management of Hyperuricemic Nephrolithiasis : Formulation, optimization, and evaluation of ABNPs for kidney targeting.

AAPS PharmSciTech 2020 Jun 2;21(5):164. Epub 2020 Jun 2.

Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India.

The aim of present research work was to design, fabricate, optimize, and evaluate allopurinol (ALLO)-loaded bovine serum albumin nanoparticles (ABNPs) for kidney targeting of the drug and exploring the potential of fabricated ABNPs for management of hyperuricemia-related nephrolithiasis. ABNP formulation was prepared by employing desolvation technique, and its optimization was conducted by 2-factor-3-level central composite design (CCD) in order to achieve minimum particle size (PSA) and polydispersity index (PDI), maximum entrapment efficiency (EE), and zeta potential (ZP). Further, the optimized formulation (ABNPs) was also assessed for in vitro drug release study, TEM, DSC, XRD analysis, FTIR spectroscopy, and in vivo animal study. Read More

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http://dx.doi.org/10.1208/s12249-020-01695-zDOI Listing

DIBc nano metal-organic framework improves biochemical and pathological parameters of experimental chronic kidney disease.

J Trace Elem Med Biol 2020 May 11;61:126547. Epub 2020 May 11.

Urology and Nephrology Research Center, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The growing morbidity and mortality rate of chronic kidney disease (CKD) has forced researchers to find more efficient strategies for controlling this disease. Studies have proven the important role of alteration in iron, zinc and selenium metabolism in CKD pathological process. Nanotechnology, through synthetizing nano metal-organic framework (NMOF) structures, can be employed as a valuable strategy for using these trace elements as the key for modification and improvement of CKD-related pathological events. Read More

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http://dx.doi.org/10.1016/j.jtemb.2020.126547DOI Listing

The role of uric acid in inflammasome-mediated kidney injury.

Curr Opin Nephrol Hypertens 2020 Jul;29(4):423-431

Nephrology Division, Federal University of São Paulo.

Purpose Of Review: Uric acid is produced after purine nucleotide degradation, upon xanthine oxidase catalytic action. In the evolutionary process, humans lost uricase, an enzyme that converts uric acid into allantoin, resulting in increased serum uric acid levels that may vary according to dietary ingestion, pathological conditions, and other factors. Despite the controversy over the inflammatory role of uric acid in its soluble form, crystals of uric acid are able to activate the NLRP3 inflammasome in different tissues. Read More

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http://dx.doi.org/10.1097/MNH.0000000000000619DOI Listing

Uric acid in diabetic nephropathy.

J Chin Med Assoc 2020 May 20. Epub 2020 May 20.

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.

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http://dx.doi.org/10.1097/JCMA.0000000000000349DOI Listing

Analysis of clinical and laboratory characteristics and pathology of lupus nephritis-based on 710 renal biopsies in China.

Clin Rheumatol 2020 May 20. Epub 2020 May 20.

Department of Nephrology, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Medical School of Chinese PLA, the First Medical Centre, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, China.

Objectives: This study aimed to analyse the clinical and laboratory characteristics of different pathologic classifications of lupus nephritis (LN) patients in terms of age at systemic lupus erythematosus (SLE) diagnosis and nephritis onset.

Method: Clinical, laboratory, and pathological data of 710 LN patients diagnosed by renal biopsy at our institution between 2000 and 2018 were retrospectively analysed. Patients were divided into the different pathological classification groups; childhood-, adult- and elderly-onset SLE groups and early- and late-onset LN groups. Read More

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http://dx.doi.org/10.1007/s10067-020-05115-2DOI Listing

Selected Atherosclerosis-Related Diseases May Differentially Affect the Relationship between Plasma Advanced Glycation End Products, Receptor sRAGE, and Uric Acid.

J Clin Med 2020 May 10;9(5). Epub 2020 May 10.

Department of General Chemistry, Chair of Chemistry and Clinical Biochemistry, Poznan University of Medical Sciences, Rokietnicka 8, 60-806 Poznan, Poland.

Our study aimed to identify the relationship between advanced glycation end products (AGEs), soluble receptor for advanced glycation end products (sRAGE), the AGEs/sRAGE, and uric acid (UA) levels in selected atherosclerosis diseases, i.e., abdominal aortic aneurysms (AAA), aortoiliac occlusive disease (AIOD), and chronic kidney disease (CKD), resulting from apparent differences in oxidative stress intensity. Read More

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http://dx.doi.org/10.3390/jcm9051416DOI Listing

Features of the interconnection of traditional risk factors and il-10 with the activity of the inflammatory process and atherosclerosis development in patients with psoriatic arthritis.

Wiad Lek 2020 ;73(5):914-919

Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine.

Objective: The aim: To determine the features of atherosclerotic process, cardiovascular risk in patients with PsA.

Patients And Methods: Materials and methods: The study included 42 patients with PsA who did not have atherosclerotic CVD, diabetes, chronic kidney disease and other serious diseases, did not take statins, the comparingl group consisted of 20 patients with psoriasis (PS) and 20 practically healthy individuals who had no signs of rheumatic, infectious and other inflammatory diseases were screened.

Results: Results: It was revealed that in patients with PsA, the severity of the atherosclerotic process is more compared with patients with PS (the RF profiles were the same). Read More

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January 2020

Clinical Predictors of the Hypoglycemic Effect of Sodium-Glucose Co-transporter-2 Inhibitors in Hyperuricemic Patients: A Retrospective Descriptive Observational Study.

Biol Pharm Bull 2020 ;43(5):782-787

Department of Pharmacy, Tokyo Women's Medical University Medical Center East.

Sodium-glucose co-transporter-2 (SGLT2) inhibitors decrease glycated hemoglobin (HbA1c) and prevent the progression of cardiovascular and kidney diseases. Because uric acid and electrolytes are physiologically similar to blood glucose in renal excretion, we assessed predictors for the hypoglycemic effect of SGLT2 inhibitor treatment by focusing on serum uric acid and serum electrolytes. We performed a retrospective descriptive observational study at the Tokyo Women's Medical University, Medical Center East, from June 2015 to July 2018. Read More

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http://dx.doi.org/10.1248/bpb.b19-00785DOI Listing
January 2020

BCc1 Nanomedicine Therapeutic Effects in Streptozotocin and High-Fat Diet Induced Diabetic Kidney Disease.

Diabetes Metab Syndr Obes 2020 17;13:1179-1188. Epub 2020 Apr 17.

Urology and Nephrology Research Center, Shahid Labbafinejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: One common feature of chronic diseases, such as cancer, diabetes and chronic kidney disease (CKD), is the disruption of iron metabolism and increase in labile iron pool, which can result in excessive production of harmful oxidative stress. The proper management of iron metabolism in this situation can be a valuable tool to ameliorate pathological events.

Materials And Methods: In the previous studies, the anti-neoplastic effects of BCc1, a nanochelating-based nanomedicine with iron-chelating property, were demonstrated in cell culture, animal models and clinical trials. Read More

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http://dx.doi.org/10.2147/DMSO.S240757DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173843PMC

Plasma chemokine CXC motif-ligand 16 as a predictor of renal prognosis in immunoglobulin A nephropathy.

Ann Transl Med 2020 Mar;8(6):381

Department of Nephrology, Division of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Background: There are few non-invasive biomarkers that have been identified to improve the risk stratification of patients with IgA nephropathy (IgAN). CXCL16 has been shown to play a key role as a chemoattractant, adhesion, and fibrosis factor in inflammatory disease. This study evaluated the potential for CXCL16 plasma as a potential biomarker in patients with IgAN. Read More

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http://dx.doi.org/10.21037/atm.2020.02.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186753PMC

Cardiorenal Effects of Pharmaceutical Plant Effluent in Mice (Mus musculus).

Niger J Physiol Sci 2019 Dec 31;34(2):215-221. Epub 2019 Dec 31.

Zoology Unit, Department of Bioscience and Biotechnology, Kwara State University, Malete.

Many pharmaceutical industries carelessly handle their effluents and indiscriminately release same to aquatic environment. These effluents often find their ways into surface and ground waters, contaminating public water and thus, serving as a potential threat to animals and human health. In this study, we investigated the cardiorenal effects of chronic oral exposure to pharmaceutical effluent in mice. Read More

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December 2019

A prospective controlled study of metabolic and physiologic effects of kidney donation suggests that donors retain stable kidney function over the first nine years.

Kidney Int 2020 Feb 3. Epub 2020 Feb 3.

Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

While there have been numerous studies of living kidney donors, most have been retrospective without suitable controls and have yielded conflicting results. To clarify this we studied 205 living donor candidates and 203 controls having no medical conditions precluding donation. Before and at six months, one, two, three, six, and nine years after donation we measured iohexol glomerular filtration rate, clinic blood pressure, urine protein excretion and metabolic parameters reported to be affected by kidney function. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.017DOI Listing
February 2020

Purine-blended nanofiber woven flexible nanomats for SERS-based analyte detection.

Chem Commun (Camb) 2020 May 23;56(43):5795-5798. Epub 2020 Apr 23.

Department of Chemistry Indian Institute of Technology Kanpur, Kanpur 208016, UP, India.

Flexible and free-standing polymeric fibers, coupled with metal nanoparticles, present an excellent opportunity for highly sensitive surface-enhanced Raman scattering (SERS) spectroscopy-based detection platforms. Such host matrices are prepared by only a few preferred methods, followed by induction of metal nanoparticle aggregation in a protected environment to afford functional SERS platforms. We provide an interesting advance in this area by choosing a thiol-modified purine (L)-polymer blend, obtained through the electrospinning process, for directed decoration with gold nanoparticles. Read More

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http://dx.doi.org/10.1039/d0cc00648cDOI Listing

Renoprotective effects of vitamin D3 supplementation in a rat model of metabolic syndrome.

Eur J Nutr 2020 Apr 22. Epub 2020 Apr 22.

Department of Anatomy and Embryology, Faculty of Human Medicine, Zagazig University, Zagazig, Egypt.

Purpose: The study aimed to investigate the potential nephroprotective effects of vitamin D3 in metabolic syndrome (MetS) and the molecular basis of the underlying mechanisms of its action.

Methods: MetS was induced in adult male Wistar rat‏s by adding fructose (10%) to every day drinking water and salt (3%) to the diet. Six weeks after fructose/salt consumption, fasting serum lipid profile and uric acid levels were determined, an oral glucose tolerance test (OGTT) was performed and kidney function was checked. Read More

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http://dx.doi.org/10.1007/s00394-020-02249-6DOI Listing

HLA-B27 Negativity Is Associated With Renal Function Decline in Patients With Ankylosing Spondylitis and Secondary IgA Nephropathy.

Front Med (Lausanne) 2020 7;7:89. Epub 2020 Apr 7.

National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China.

This study aimed to determine the impact of HLA-B27 on clinical phenotype and renal function during follow-up periods in patients with ankylosing spondylitis (AS) and secondary IgA nephropathy (IgAN). This single-center retrospective study included 71 AS patients with secondary IgAN. Renal function decline was defined as a mean eGFR decline of more than 5 mL/min/1. Read More

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http://dx.doi.org/10.3389/fmed.2020.00089DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154124PMC

Early tonsillectomy for severe IgA nephropathy significantly reduces proteinuria.

Pediatr Int 2020 Apr 21. Epub 2020 Apr 21.

Department of Pediatrics, Kindai University, Faculty of Medicine, Osaka-Sayama, Japan.

Background: Early multiple-drug therapy for severe childhood IgA nephropathy prevents the progression of nephritis and improves long-term prognosis. Recent studies have focused on the relationship between the pathophysiology of IgA nephropathy and tonsillar focal infection, and the efficacy of tonsillectomy with methylprednisolone pulse therapy in children has been demonstrated. However, no study has reported on the relationship between the period from diagnosis to tonsillectomy and the long-term prognosis of IgA nephropathy. Read More

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http://dx.doi.org/10.1111/ped.14264DOI Listing

CARDIOMETABOLIC RISK FACTORS ASSOCIATED WITH RENAL FUNCTION IN APPARENTLY HEALTHY YOUNG STUDENTS: A CROSS-SECTIONAL STUDY.

Rev Invest Clin 2020 ;72(2):95-102

South Texas Diabetes and Obesity Institute and Department of Human Genetics, School of Medicine, University of Texas Rio Grande Valley, Edinburg, Texas, USA.

Background: Cardiometabolic risk factors (CMRFs) appear decades before developing chronic kidney disease (CKD) in adulthood.

Objective: The objective of the study was to identify the prevalence and association between CMRFs and kidney function in apparently healthy young adults (18-25 years old).

Methods: We included 5531 freshman year students. Read More

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http://dx.doi.org/10.24875/RIC.19003204DOI Listing
January 2020

A population-specific low-frequency variant of SLC22A12 (p.W258*) explains nearby genome-wide association signals for serum uric acid concentrations among Koreans.

PLoS One 2020 9;15(4):e0231336. Epub 2020 Apr 9.

Departments of Family Medicine, Seoul National University College of Medicine and Seoul National University Hospital, Seoul, Republic of Korea.

Prolonged hyperuricemia is a cause of gout and an independent risk factor for chronic health conditions including diabetes and chronic kidney diseases. Genome-wide association studies (GWASs) for serum uric acid (SUA) concentrations have repeatedly confirmed genetic loci including those encoding uric acid transporters such as ABCG2 and SLC9A2. However, many single nucleotide polymorphisms (SNPs) found in GWASs have been common variants with small effects and unknown functions. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231336PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145145PMC

Initial serum creatinine concentration affects clinical outcomes in patients with IgA nephropathy treated with mycophenolate mofetil combined with low-dose prednisone.

Exp Ther Med 2020 May 5;19(5):3369-3376. Epub 2020 Mar 5.

Department of Nephrology, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, Guangdong 518035, P.R. China.

Indicators for predicting the efficacy of mycophenolate mofetil (MMF) have so far remained elusive. The present study aimed to identify predictive indicators of the efficacy of MMF combined with low-dose prednisone in patients with IgA nephropathy. A total of 598 patients presenting with primary IgA nephropathy at our center were screened. Read More

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http://dx.doi.org/10.3892/etm.2020.8573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132257PMC

Clinicopathological features and prognosis in patients with idiopathic membranous nephropathy with hypertension.

Exp Ther Med 2020 Apr 10;19(4):2615-2621. Epub 2020 Feb 10.

Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China.

The present study analyzed the clinicopathological features and prognosis in patients with idiopathic membranous nephropathy (IMN) with hypertension. In the hypertension group, significant differences were found in the age, hypertension history, systolic blood pressure, diastolic blood pressure (DBP), mean arterial pressure, albumin, serum creatinine, low-density lipoprotein, 24 h urine protein levels, calculated estimated glomerular filtration rate (e-GFR), glomerular sclerosis, segmental sclerosis, ischemic sclerosis, interstitial fibrosis, tubular atrophy and vascular lesion compared with the non-hypertension group (P<0.05). Read More

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http://dx.doi.org/10.3892/etm.2020.8506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7086205PMC

Fructose Production and Metabolism in the Kidney.

J Am Soc Nephrol 2020 May 6;31(5):898-906. Epub 2020 Apr 6.

Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado.

Understanding fructose metabolism might provide insights to renal pathophysiology. To support systemic glucose concentration, the proximal tubular cells reabsorb fructose as a substrate for gluconeogenesis. However, in instances when fructose intake is excessive, fructose metabolism is costly, resulting in energy depletion, uric acid generation, inflammation, and fibrosis in the kidney. Read More

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http://dx.doi.org/10.1681/ASN.2019101015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217403PMC

Hyperuricemia and its association with adiposity and dyslipidemia in Northwest China: results from cardiovascular risk survey in Xinjiang (CRS 2008-2012).

Lipids Health Dis 2020 Apr 1;19(1):58. Epub 2020 Apr 1.

State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, Clinical Medical Research Institute, the First Affiliated Hospital of Xinjiang Medical University, 137 Liyushan South Road, Urumqi, 830054, Xinjiang, China.

Background: Hyperuricemia predisposes to gout, which may result in tophi, kidney stones, or urate nephropathy even kidney failure. Many metabolic risk factors and disorders has been recognized as a key risk factor contributing to development of hyperuricemia.

Aim: To determine the prevalence of hyperuricemia and its association with adiposity and dyslipidemia. Read More

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http://dx.doi.org/10.1186/s12944-020-01211-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7115071PMC

[Predictors of kidney function in a cohortof Mexican adults].

Salud Publica Mex 2020 Mar-Apr;62(2):156-165

Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.

Objective: Our aim was to examine prospectively predictors of subclinical renal alterations among adults without chronic kidney disease.

Materials And Methods: We analyzed data from a cohort of Mexican adults (n=757). Kidney function (2010) was assessed with the estimated glomerular filtration rate (eGFR-Cr), serum creatinine and uric acid. Read More

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http://dx.doi.org/10.21149/10615DOI Listing

The Optimal Range of Serum Uric Acid for Cardiometabolic Diseases: A 5-Year Japanese Cohort Study.

J Clin Med 2020 Mar 30;9(4). Epub 2020 Mar 30.

Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

The optimal range of serum uric acid (urate) associated with the lowest risk for developing cardiometabolic diseases is unknown in a generally healthy population. This 5-year cohort study is designed to identify the optimal range of serum urate. The data were collected from 13,070 Japanese between ages 30 and 85 at the baseline (2004) from the Center for Preventive Medicine, St. Read More

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http://dx.doi.org/10.3390/jcm9040942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231289PMC

Complications of Renal Transplantation That Influence the Presence of Hyperuricemia in Its First Year of Evolution.

Transplant Proc 2020 May 18;52(4):1147-1151. Epub 2020 Mar 18.

Kidney Diseases Medical Research Unit, National Healthcare Medical Center Siglo XXI, IMSS, México City, México.

Introduction: Renal transplantation (RT) has evolved to improve its functionality. Some factors have been little studied, one of which is hyperuricemia and its impact on renal graft function. The objective of this study is to determine the prevalence of complications of renal transplantation and its influence on hyperuricemia values in the first year of evolution. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.062DOI Listing

Uric acid and Hypertension: An Update with Recommendations.

Am J Hypertens 2020 Mar 17. Epub 2020 Mar 17.

Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora CO.

The association between increased serum urate and hypertension has been a subject of intense controversy. Extracellular uric acid drives uric acid deposition in gout, kidney stones, and possibly vascular calcification. Mendelian randomization studies, however, indicate that serum urate is likely not the causal factor in hypertension although it does increase the risk for sudden cardiac death and diabetic vascular disease. Read More

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http://dx.doi.org/10.1093/ajh/hpaa044DOI Listing

Compliance With Biochemical Objectives in Patients on Renal Replacement Therapy Before Kidney Transplantation in Mexico.

Transplant Proc 2020 May 11;52(4):1090-1093. Epub 2020 Mar 11.

Medical Research Unit in Nephrological Diseases, Specialty Hospital, 21st Century National Medical Center, Mexican Social Security Institute, Mexico City, Mexico.

Objectives: The biochemical conditions in which patients arrive before renal transplantation (RT) are rarely evaluated; examples of them are found in the Dialysis Outcomes and Practice Patterns Study (DOPPS). The objective of our study was to ascertain the fulfillment of biochemical goals for patients on renal replacement therapy before RT.

Material And Methods: Observational, retrospective study of patients who were on a RT protocol between 2012 and 2017 in 2 RT centers in Mexico. Read More

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http://dx.doi.org/10.1016/j.transproceed.2020.01.050DOI Listing

Effects of hyperuricemia on incident renal replacement therapy and all-cause mortality among patients with chronic kidney disease stages 3-5: a retrospective cohort study.

Sao Paulo Med J 2019 Nov-Dec;137(6):523-529

MD, PhD. Assistant Professor, Department of Internal Medicine, Division of Endocrinology and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan.

Background: Findings regarding the effects of hyperuricemia on renal function and mortality have been inconsistent.

Objectives: To investigate the effects of hyperuricemia on incident renal replacement therapy and all-cause mortality among patients with chronic kidney disease (CKD).

Design And Setting: Retrospective cohort study conducted in a medical center in Taiwan. Read More

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http://dx.doi.org/10.1590/1516-3180.2019.0406211019DOI Listing

STone Episode Prediction: Development and validation of the prediction nomogram for urolithiasis.

Int J Urol 2020 Apr 8;27(4):344-349. Epub 2020 Mar 8.

Department of Urology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Objectives: To develop and validate a nomogram predicting the occurrence of a stone episode, given the lack of such predicting risk tools for urolithiasis.

Methods: We retrospectively analyzed 1305 patients with urolithiasis and 2800 community-dwelling individuals who underwent a comprehensive health survey. The STone Episode Prediction nomogram was created based on data from the medical records of 600 patients with urolithiasis and 1300 controls, and was validated using a different population of 705 patients with urolithiasis and 1500 controls. Read More

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http://dx.doi.org/10.1111/iju.14203DOI Listing

Serum uric acid is independently associated with diabetic nephropathy but not diabetic retinopathy in patients with type 2 diabetes mellitus.

J Chin Med Assoc 2020 Apr;83(4):350-356

Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China.

Background: This study aims to investigate the relationship between serum uric acid (SUA) and the severity of diabetic nephropathy (DN) and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods: A total of 2961 patients were enrolled in the present cross-sectional study. The severity of DN was determined by 24-hour urinary albumin excretion (UAE), which was classified as normal (UAE <30 mg/24 h), microalbuminuria (UAE: 30-299 mg/24 h), and macroalbuminuria (≥300 mg/24 h). Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000285DOI Listing

[Nephrolithiasis: From mechanisms to preventive medical treatment].

Nephrol Ther 2020 Feb 29;16(1):65-75. Epub 2020 Feb 29.

Service de physiologie-explorations fonctionnelles, hôpital Tenon, AP-HP, 75020 Paris, France.

Renal lithiasis is a frequent pathology (prevalence ranging from 10 to 12% in France) and a recurrent condition. It is associated with chronic kidney disease and is responsible for 2 to 3% of cases of end-stage renal disease, especially if it is associated with nephrocalcinosis and/or is part of a monogenic disease (1.6% of lithiasis in adults, including 1% of cystinuria). Read More

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http://dx.doi.org/10.1016/j.nephro.2020.01.001DOI Listing
February 2020

Laparoscopic sleeve gastrectomy: a study of efficiency in treatment of metabolic syndrome components, comorbidities and influence on certain biochemical markers.

Wideochir Inne Tech Maloinwazyjne 2020 Mar 25;15(1):136-147. Epub 2019 Apr 25.

First Department of General and Endocrine Surgery, University Clinical Hospital of Bialystok, Bialystok, Poland.

Introduction: The worldwide outbreak of morbid obesity forced contemporary medicine to adopt a multidisciplinary approach, which led to the description of metabolic syndrome (MS): a disease with self-aggravating components and one of the most important causes of morbidity and mortality. The need for therapeutic methods provoked development of metabolic surgery, which nowadays give possibilities for safe and effective treatment of all MS aspects simultaneously and improves many obesity-related comorbidities.

Aim: To assess the laparoscopic sleeve gastrectomy (LSG) procedure's efficiency in resolving MS components, treating comorbidities and to analyze the influence on certain biochemical markers in 1-year follow-up. Read More

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http://dx.doi.org/10.5114/wiitm.2019.84718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020700PMC

Mangiferin Ameliorates Hyperuricemic Nephropathy Which Is Associated With Downregulation of AQP2 and Increased Urinary Uric Acid Excretion.

Front Pharmacol 2020 7;11:49. Epub 2020 Feb 7.

Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Hyperuricemia is characterized by abnormally high level of circulating uric acid in the blood and is associated with increased risk of kidney injury. The pathophysiological mechanisms leading to hyperuricemic nephropathy (HN) involve oxidative stress, endothelial dysfunction, inflammation, and fibrosis. Mangiferin is a bioactive C-glucoside xanthone, which has been exerting anti-inflammatory, anti-fibrotic, and antioxidative effects in many diseases. Read More

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http://dx.doi.org/10.3389/fphar.2020.00049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020245PMC
February 2020

SPTB related spherocytosis in a three-generation family presenting with kidney failure in adulthood due to co-occurrence of UMOD disease causing variant.

Nefrologia 2020 Feb 26. Epub 2020 Feb 26.

University Medical Centre Ljubljana, University Children's Hospital, Institute for Special Laboratory Diagnostics, Ljubljana, Slovenia; University of Ljubljana, Faculty of Medicine, Institute of Biochemistry, Ljubljana, Slovenia. Electronic address:

Background: Hereditary spherocytosis is clinically and genetically heterogeneous disorder and its clinical characteristics are spherocytosis, anaemia, jaundice and splenomegaly. The aetiology is associated to the genes encoding proteins involved in the interaction between the erythrocyte membrane and the lipid bilayer. Causative variants in βI-spectrin (SPTB) gene presenting as mild to moderately severe disease are responsible for approximately 25% cases in the USA and Europe. Read More

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http://dx.doi.org/10.1016/j.nefro.2019.10.009DOI Listing
February 2020

Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide.

Toxicol Res (Camb) 2019 Nov 7;8(6):850-861. Epub 2019 Aug 7.

School of Chinese Materia Medica , Tianjin University of Traditional Chinese Medicine , Jian Kang Chan Ye Yuan , Jinghai Dist. , Tianjin 301617 , China . Email: ; Email: ; ; Tel: +86-22-59596223.

Triptolide (TP) is one of the important active components in , which shows strong anti-inflammatory and immunomodulatory effects. However, a large number of literature studies have reported that TP is the main component causing nephrotoxicity, and the mechanism of nephrotoxicity has not yet been revealed. Therefore, it is of great practical significance to clarify the toxicity mechanism of TP. Read More

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http://dx.doi.org/10.1039/c9tx00067dDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017871PMC
November 2019

Predictors of Hyperuricemia after Kidney Transplantation: Association with Graft Function.

Medicina (Kaunas) 2020 Feb 25;56(3). Epub 2020 Feb 25.

Pauls Stradins Clinical University Hospital, Centre of Nephrology of Latvia, LV-1002 Riga, Latvia.

Background: In kidney transplant recipients (KTR), hyperuricemia (HU) is a commonly-observed phenomenon, due to calcineurin inhibitors and reduced kidney graft function. Factors predicting HU, and its association with graft function, remains equivocal.

Methods: We conducted a retrospective longitudinal study to assess factors associated with HU in KTR, and to determine risk factors associated with graft function, measured as glomerular filtration rate (GFR). Read More

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http://dx.doi.org/10.3390/medicina56030095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7143203PMC
February 2020

Uric Acid and Arterial Stiffness.

Ther Clin Risk Manag 2020 28;16:39-54. Epub 2020 Jan 28.

2nd Department of Internal Medicine.

Hyperuricemia is usually associated with hypertension, diabetes mellitus, metabolic syndrome and chronic kidney disease. Accumulating data from epidemiological studies indicate an association of increased uric acid (UA) with cardiovascular diseases. Possible pathogenic mechanisms include enhancement of oxidative stress and systemic inflammation caused by hyperuricemia. Read More

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http://dx.doi.org/10.2147/TCRM.S232033DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995306PMC
January 2020

Hydrogen sulfide renal protective effects: possible link between hydrogen sulfide and endogenous carbon monoxide in a rat model of renal injury.

Cell Stress Chaperones 2020 Mar 22;25(2):211-221. Epub 2020 Feb 22.

Deraya University, New Minya City, Egypt.

Hydrogen sulfide (HS), along with nitric oxide (NO) and carbon monoxide (CO), proved to have renoprotective effects in various renal diseases. Therefore, this study investigated the renoprotective effect of HS, in a renal injury model, and its crosstalk with other gasotransmitters such as CO. Thirty-two adult rats were divided into four groups: control, gentamicin (GEN)-treated, GEN + sodium hydrosulfide (NaHS), and GEN + NaHS + zinc protoporphyrin (ZnPP) groups. Read More

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http://dx.doi.org/10.1007/s12192-019-01055-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7058727PMC

Abnormal metabolism of gut microbiota reveals the possible molecular mechanism of nephropathy induced by hyperuricemia.

Acta Pharm Sin B 2020 Feb 30;10(2):249-261. Epub 2019 Oct 30.

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences/Peking Union Medical College, Beijing 100050, China.

The progression of hyperuricemia disease is often accompanied by damage to renal function. However, there are few studies on hyperuricemia nephropathy, especially its association with intestinal flora. This study combines metabolomics and gut microbiota diversity analysis to explore metabolic changes using a rat model as well as the changes in intestinal flora composition. Read More

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http://dx.doi.org/10.1016/j.apsb.2019.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016297PMC
February 2020

An echocardiographic predictor of contrast-induced nephropathy following percutaneous coronary intervention in acute coronary syndrome: aortic valve sclerosis.

Scand Cardiovasc J 2020 Feb 19:1-5. Epub 2020 Feb 19.

Faculty of Medicine, Department of Cardiology, Recep Tayyip Erdogan University, Rize, Turkey.

Aortic valve sclerosis (AVS) is closely related to endothelial dysfunction. The association of AVS with contrast-induced nephropathy (CIN) is unknown. We planned to investigate the relationship of AVS besides known parameters with CIN. Read More

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http://dx.doi.org/10.1080/14017431.2020.1727001DOI Listing
February 2020
1.104 Impact Factor

Impact of Demographic Factors and Systemic Disease on Urinary Stone Risk Parameters Amongst Stone Formers.

Rev Urol 2019 ;21(4):158-165

Department of Urology, University of Alabama-Birmingham Birmingham, AL.

This article examines via multivariate analysis the associations between demographic factors and systemic diseases on stone risk parameters in a stone-forming population. A retrospective chart review of adult stone formers who completed 24-hour urine collections from April 2004 through August 2015 was performed. Data was collected on age, sex, race, body mass index (BMI), and diagnoses of diabetes and hypertension. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020277PMC
January 2019

[Prediction of 6-year incidence risk of chronic kidney disease in the elderly aged 65 years and older in 8 longevity areas in China].

Zhonghua Liu Xing Bing Xue Za Zhi 2020 Jan;41(1):42-47

National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.

To establish a prediction model for 6-year incidence risk of chronic kidney disease (CKD) in the elderly aged 65 years and older in China. In this prospective cohort study, we used the data of 3 742 participants collected during 2008/2009-2014 and during 2012-2017/2018 from Healthy Aging and Biomarkers Cohort Study, a sub-cohort of the Chinese Longitudinal Healthy Longevity Survey. Two follow up surveys for renal function were successfully conducted for 1 055 participants without CKD in baseline survey. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2020.01.009DOI Listing
January 2020

Ninety-Day Nephrotoxicity Evaluation of 3-MCPD 1-Monooleate and 1-Monostearate Exposures in Male Sprague Dawley Rats Using Proteomic Analysis.

J Agric Food Chem 2020 Mar 21;68(9):2765-2772. Epub 2020 Feb 21.

Department of Nutrition and Food Science, University of Maryland, College Park, Maryland 20742, United States.

Fatty acid esters of 3-monochloropropane 1,2-diol (3-MCPD esters) are processing-induced food toxicants, with the kidney as their major target organ. For the first time, this study treated Sprague Dawley (SD) rats with 3-MCPD 1-monooleate at 10 and 100 mg/kg BW/day and 1-monostearate at 15 and 150 mg/kg BW/day for 90 days and examined for their potential semi-long-term nephrotoxicity and the associated molecular mechanisms. No bodyweight difference was observed between groups during the study. Read More

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http://dx.doi.org/10.1021/acs.jafc.0c00281DOI Listing

Association between uric acid levels and cardio-renal outcomes and death in patients with type 2 diabetes: A subanalysis of EMPA-REG OUTCOME.

Diabetes Obes Metab 2020 Feb 6. Epub 2020 Feb 6.

St Michael's Hospital, Division of Cardiology, University of Toronto, Toronto, Ontario, Canada.

In the EMPA-REG OUTCOME trial, we explored the association between pre-randomization uric acid level tertile (<309.30 μmol/L; 309.30 to <387. Read More

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http://dx.doi.org/10.1111/dom.13991DOI Listing
February 2020

Unfavorable Reduction in the Ratio of Endothelin B to A Receptors in Experimental 5/6 Nephrectomy and Adenine Models of Chronic Renal Insufficiency.

Int J Mol Sci 2020 Jan 31;21(3). Epub 2020 Jan 31.

Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.

Chronic renal insufficiency (CRI) is characterized by increased endothelin 1 (ET-1) synthesis. We studied rat kidney endothelin receptor A (ETA) and receptor B (ETB) expressions after 12 and 27 weeks of 5/6 nephrectomy, and after 12 weeks of 0.3% adenine diet, representing proteinuric and interstitial inflammation models of CRI, respectively. Read More

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http://dx.doi.org/10.3390/ijms21030936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7037353PMC
January 2020

Empagliflozin Attenuates Hyperuricemia by Upregulation of ABCG2 via AMPK/AKT/CREB Signaling Pathway in Type 2 Diabetic Mice.

Int J Biol Sci 2020 1;16(3):529-542. Epub 2020 Jan 1.

NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & Tianjin Institute of Endocrinology, Tianjin 300134, China.

Hyperuricemia (HUA) is a metabolic disease characterized by elevated serum uric acid (SUA). Empagliflozin, a kind of sodium-glucose cotransporter 2 inhibitors, has recently emerged as a new antidiabetic agent by facilitating glucose excretion in urine. Moreover, there was evidence of SUA reduction following treatment with empagliflozin in addition to glycaemic control, while the molecular mechanisms remain unknown. Read More

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http://dx.doi.org/10.7150/ijbs.33007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6990905PMC
January 2020

High-sensitivity Troponin I Predicts Galectin-3 in Chronic Kidney Disease Patients.

Int Urol Nephrol 2020 Mar 1;52(3):533-540. Epub 2020 Feb 1.

Division of Nephrology, Department of Medicine, National University Hospital, Singapore, Singapore.

Purpose: Plasma galectin-3 (pG3) regulates inflammation. B-type natriuretic peptide (BNP), high-sensitivity Troponin I (hsTnI), and pG3 concentrations are elevated in chronic kidney disease (CKD) patients. The associations of pG3 with hsTnI/BNP are unclear. Read More

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http://dx.doi.org/10.1007/s11255-020-02390-5DOI Listing

Anti-rasburicase antibodies induce clinical refractoriness by inhibiting the enzyme catalytic activity.

Hematol Oncol 2020 Apr 27;38(2):204-206. Epub 2020 Jan 27.

Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale and Ospedale Maggiore della Carità, Novara, Italy.

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http://dx.doi.org/10.1002/hon.2700DOI Listing

Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic Glomerulonephritis.

Electrolyte Blood Press 2019 Dec 31;17(2):54-61. Epub 2019 Dec 31.

Department of Nephrology, Kyung-Hee University Hospital, Kyung-Hee University School of Medicine, Seoul, Korea.

Background: Several factors had been suggested to contribute to the development of hypertension in chronic glomerulonephritis (GN). This study was conducted to find the association of baseline blood pressure (BP) with pathophysiologic findings and later renal progression in chronic GN.

Methods: Clinico-pathological findings including serum creatinine (Cr), proteinuria, pathological findings, and urinary Na excretion were analyzed in a total of 233 patients with IgA nephropathy from The Kyung-Hee Cohort of GN. Read More

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http://dx.doi.org/10.5049/EBP.2019.17.2.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962442PMC
December 2019

Hyperuricemia is associated with a lower glomerular filtration rate in pediatric sickle cell disease patients.

Pediatr Nephrol 2020 May 20;35(5):883-889. Epub 2020 Jan 20.

Internal Medicine, Division of Hematology, Virginia Commonwealth University, 730 E. Broad St, Richmond, VA, 23219, USA.

Background: Sickle cell nephropathy (SCN) is a progressive disease that contributes significant morbidity and mortality in sickle cell disease (SCD), yet it remains poorly understood. Hyperuricemia negatively impacts renal function in the non-sickle cell population but is understudied in SCD.

Methods: We performed a cross-sectional analysis of the first 78 pediatric SCD patients enrolled in a cohort study. Read More

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http://dx.doi.org/10.1007/s00467-019-04432-2DOI Listing