35,810 results match your criteria Uric Acid Nephropathy


Alterations of Renal Epithelial Glucose and Uric Acid Transporters in Fructose Induced Metabolic Syndrome.

Kidney Blood Press Res 2018 Dec 7;43(6):1822-1831. Epub 2018 Dec 7.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung,

Background/aims: Hyperglycemia and hyperuricemia are two major disorders of Metabolic syndrome. Kidney plays a crucial role in maintaining the homeostasis of uric acid and glucose. The aim of the study was to examine the changes of renal glucose and uric acid transporters in animals with metabolic syndrome. Read More

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December 2018

Prediction of ESRD in IgA Nephropathy Patients from an Asian Cohort: A Random Forest Model.

Kidney Blood Press Res 2018 Dec 7;43(6):1852-1864. Epub 2018 Dec 7.

Department of Nephrology, the Second Xiangya Hospital, Central South University, Key laboratory of Kidney disease and Blood Purification in Hunan Province, Changsha,

Background/aims: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied.

Methods: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Read More

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December 2018

Uric acid and angiotensin II additively promote inflammation and oxidative stress in human proximal tubule cells by activation of toll-like receptor 4.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Internal Medicine, University of Genoa and Ospedale Policlinico San Martino-IST, Genova, Italy.

Renal proximal tubular cells (PTECs) participate in several mechanisms of innate immunity, express toll-like receptors (TLRs), and proinflammatory cytokines. Hyperuricemia may be a promoter of inflammation and renal damage. Angiotensin II (Ang II) modulate immune and inflammatory responses in renal tubular cells. Read More

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December 2018

Clinical Characteristics and Outcome of Morbidly Obese Bariatric Patients with Concurrent Hepatitis C Viral Infection.

Obes Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of International Business, Chien Hsin University of Science and Technology, Taoyuan, Taiwan.

Background: Hepatitis C virus (HCV) is an important cause of liver cirrhosis and its complications. The safety and efficacy of bariatric surgery in patients with HCV infection is not clear.

Methods: Charts were reviewed to identify patients with HCV infection before bariatric surgery. Read More

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December 2018

Effect of Laparoscopic Sleeve Gastrectomy on Type 2 Diabetes Mellitus in Patients with Body Mass Index less than 30 kg/m.

Obes Surg 2018 Dec 8. Epub 2018 Dec 8.

Department of Bariatric and Metabolic Surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China.

Background: Laparoscopic sleeve gastrectomy (LSG) has been proved to be the most effective treatment strategy for the treatment of type 2 diabetes mellitus (T2DM) with a body mass index ≥ 30 kg/m achieving high remission rates. However, there are few clinical studies on the treatment of T2DM patients with a body mass index less than 30 kg/m by LSG. This study aims to study the effect of LSG on type 2 diabetes mellitus(T2DM) in patients with a body mass index (BMI) less than 30 kg/m. Read More

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December 2018

A non-enzymatic voltammetric xanthine sensor based on the use of platinum nanoparticles loaded with a metal-organic framework of type MIL-101(Cr). Application to simultaneous detection of dopamine, uric acid, xanthine and hypoxanthine.

Mikrochim Acta 2018 Dec 10;186(1). Epub 2018 Dec 10.

School of Materials Science and Engineering, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin, 150040, China.

A Cr-based metal-organic framework MIL-101(Cr) was used to load platinum nanoparticles (PtNPs) that were placed on a glassy carbon electrode (GCE). The modified GCE was used as a non-enzymatic xanthine sensor. Compared to bare GCE, it requires a strongly decreased working potential and an increased signal current for xanthine oxidation. Read More

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December 2018

Preliminary Study of Dynamic Cerebral Autoregulation in Acute Ischemic Stroke: Association With Clinical Factors.

Front Neurol 2018 26;9:1006. Epub 2018 Nov 26.

Stroke Center, Department of Neurology, the First Hospital of Jilin University, Changchun, China.

Dynamic cerebral autoregulation (dCA) is probably impaired in the acute and even subacute phases after acute ischemic stroke (AIS); however, the relationship between relevant clinical factors and dCA after AIS has not been investigated. The identification of possible determinants may therefore provide potential therapeutic targets to improve dCA in AIS. This study enrolled 67 consecutive patients diagnosed with AIS within 3 days from symptom onset. Read More

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November 2018

Studies of human hemoglobin modified with peroxynitrite: A cytotoxic metabolite generated in numerous disorders.

Int J Health Sci (Qassim) 2018 Nov-Dec;12(6):30-35

Department of Biochemistry and Biotechnology, SBS Postgraduate Institute of Biomedical Sciences and Research, Balawala, Dehradun, India.

Objectives: Peroxynitrite interacts with biomolecules through oxidative reactions or radical-mediated mechanisms leading to oxidative damage and committing cells to necrosis or/and apoptosis. Hemoglobin (Hb) is the oxygen-transporting metalloprotein found in blood that carries oxygen from the lungs to the tissues and subsequently releases it to carry out various metabolic functions. In the present study, we have isolated Hb from human blood and subjected it to modify by peroxynitrite generated . Read More

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December 2018

Levels of serum sclerostin, FGF-23, and intact parathyroid hormone in postmenopausal women treated with calcitriol.

Clin Interv Aging 2018 16;13:2367-2374. Epub 2018 Nov 16.

National Clinical Research Center for Aging and Medicine, Fudan University, Shanghai, China,

Objective: This study aimed to determine the effect of calcitriol on serum concentrations of fibroblast growth factor-23 (FGF-23), sclerostin, intact parathyroid hormone (PTH), and handgrip strength in postmenopausal women with low bone mass.

Methods: A randomized, double-blind controlled trial was carried out among 141 postmenopausal women with low bone mass. Participants were randomized into two groups: 75 participants received calcitriol 0. Read More

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November 2018

Evaluation of antioxidant, diuretic, and wound healing effect of Tulkarm honey and its effect on kidney function in rats.

Vet World 2018 Nov 25;11(10):1491-1499. Epub 2018 Oct 25.

Laboratory of Physiology, Pharmacology and Environmental Health, Faculty of Sciences, Dhar El Mehraz, BP 1796 Atlas, University Sidi Mohamed Ben Abdallah, Fez 30 000, Morocco.

Aim: The composition and activity of honey depend on its floral origin. Honey collected from Tulkarm was evaluated for physicochemical property and antioxidant content as well as a diuretic and wound healing activity. Its effect on kidney function was evaluated and compared with furosemide. Read More

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November 2018

Association between adiponectin T94G polymorphism and resistant hypertension in young-onset Taiwanese patients.

Gene 2018 Dec 7. Epub 2018 Dec 7.

Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan; Department of Internal Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Young-onset hypertensives (YOHs) with resistant hypertension (RH) have a greater long-term cardiovascular risk. The present study examined whether a functional adiponectin T94G polymorphism (rs2241766) is associated with RH in YOHs. We analyzed data from the Academia Sinica Collaborative Study on Hypertension Genetics in Taiwanese subjects to compare rs2241766 between YOHs with and without RH (≤50 years of age). Read More

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December 2018

Salivary markers of hepato-metabolic comorbidities in pediatric obesity.

Dig Liver Dis 2018 Nov 17. Epub 2018 Nov 17.

Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana" Pediatrics Section, University of Salerno, Baronissi, Salerno, Italy; European Laboratory for Food Induced Intestinal Diseases (ELFID), Naples, Italy.

Background: The pediatric obesity epidemic calls for the noninvasive detection of individuals at higher risk of complications.

Aims: To investigate the diagnostic role of combined salivary uric acid (UA), glucose and insulin levels to screen noninvasively for metabolic syndrome (MetS) and nonalcoholic fatty liver disease.

Methods: Medical history, clinical, anthropometric, and laboratory data including serum triglyceride, glucose, insulin, HOMA, HDL-cholesterol, and UA levels of 23 obese children (15 with [St+] and 8 without [St-] ultrasonographic hepatic steatosis) and 18 normal weight controls were considered. Read More

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November 2018

Urinary metabolic abnormalities in children with idiopathic hematuria.

J Pediatr Urol 2018 Nov 10. Epub 2018 Nov 10.

Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Hematuria, either macroscopic or microscopic, is an incidental finding of multiple nephrologic or urologic disorders. Disturbances of urine inhibitors or promotors have been suggested as the potential causes of isolated idiopathic hematuria in children and its recurrence. Meanwhile, appropriate treatment of these risk factors might improve secondary asymptomatic or macroscopic hematuria. Read More

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November 2018

Predictors of Symptomatic Kidney Stone Recurrence After the First and Subsequent Episodes.

Mayo Clin Proc 2018 Nov 29. Epub 2018 Nov 29.

Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN; Division of Epidemiology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To predict symptomatic recurrence among community stone formers with one or more previous stone episodes.

Patients And Methods: A random sample of incident symptomatic kidney stone formers in Olmsted County, Minnesota, was followed for all symptomatic stone episodes resulting in clinical care from January 1, 1984, through January 31, 2017. Clinical and radiographic characteristics at each stone episode predictive of subsequent episodes were identified. Read More

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November 2018

Implications of Hyperuricemia in Severe Coronary Artery Disease.

Am J Cardiol 2018 Nov 23. Epub 2018 Nov 23.

State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. Electronic address:

Hyperuricemia has been associated with mortality in patients with coronary artery disease (CAD). However, its prognostic value remains unknown in the context of severe CAD with heavy atherosclerotic burden in all 3 vessels. We used data from a large cohort of consecutive patients with severe CAD. Read More

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November 2018

Mechanistic insights of soluble uric acid-related kidney disease.

Curr Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041. China.

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Read More

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December 2018

Hyperuricemia and prognosis of acute ischemic stroke in diabetic patients.

Neurol Res 2018 Dec 11:1-7. Epub 2018 Dec 11.

b Department of Neurology , the first Affiliated Hospital of Harbin Medical University , Harbin , China.

Objectives: The relationship between hyperuricemia (HUA) and prognosis of acute ischemic stroke (AIS) is unclear. This prospective cohort study aims to evaluate potential value of HUA as a prognostic factor for AIS independent of diabetic status.

Methods: A total of 1041 consecutive patients aged from 25 to 96 with AIS were included. Read More

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December 2018

Predictive Value of Hepatorenal Status in Contrast-Induced Nephropathy Among Patients Receiving Coronary Angiography and/or Intervention: A Systematic Review and Meta-Analysis.

Angiology 2018 Dec 9:3319718816206. Epub 2018 Dec 9.

1 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background:: Low serum albumin, high blood urea nitrogen (BUN), and uric acid are regarded closely related to the incidence of contrast-induced nephropathy (CIN), whereas it remains unclear whether they can function as predictors of CIN onset. The objective of this systematic review and meta-analysis was to explore the association between abovementioned indicators and CIN incidence rate in patients receiving coronary angiography (CAG) and/or intervention.

Methods:: Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and ScienceDirect from their inception to July 13, 2018. Read More

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December 2018

Nanopillar-Assisted SERS Chromatography.

ACS Sens 2018 Dec 11. Epub 2018 Dec 11.

Practical implementation of SERS sensing is hindered by complexity of real-life samples, which often requires long and costly pretreatment and purification. Here, we present a novel nanopillar-assisted SERS chromatography (NPC-SERS) method for simultaneous quantitation of target molecules and analysis of complex, multicomponent fluids, e.g. Read More

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December 2018

Oxidation of cystatin imparted by riboflavin generated free radicals: Spectral analysis.

Int J Biol Macromol 2018 Dec 3. Epub 2018 Dec 3.

Department of Biochemistry, Faculty of life sciences, Aligarh Muslim University, Aligarh, UP 202002, India. Electronic address:

Thiol Protease inhibitors (cystatins) are endogenous natural inhibitors of cysteine proteases. They are present in all mammalians cells and body fluids. Cystatin are allocated into three major families. Read More

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December 2018
3 Reads

The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy.

Future Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Department of General Biochemistry, Faculty of Biology & Environmental Protection, University of Łódź, Pomorska 141/3, 90-236 Łódź, Poland.

Aim: To evaluate the level of lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy (ESWL).

Materials & Methods: Isoprostane concentration (8-isoPGF) was measured in urine, and thiobarbituric acid reactive substance production in serum and erythrocytes. In addition, the concentrations of selected compounds (uric acid, glucose and creatinine) were measured in serum. Read More

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December 2018

Fasting blood glucose is predictive of hypertension in a general Japanese population.

J Hypertens 2019 Jan;37(1):167-174

Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

Objective: This study was conducted to identify whether higher fasting blood glucose levels is predictive of hypertension by a large-scale longitudinal design.

Methods: We conducted a retrospective 5-year cohort study using the data from 13 201 Japanese individuals who underwent annual medical examinations in 2004 and were reevaluated 5 years later. This study included individuals without diabetes or hypertension between ages 30 and 85 years in 2004. Read More

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January 2019
2 Reads

Caspase- (8/3) Activation and Organ Inflammation in a Rat Model of Resuscitated Hemorrhagic Shock: A Role for Uric Acid.

J Trauma Acute Care Surg 2018 Nov 30. Epub 2018 Nov 30.

Centre de Recherche de l'Hôpital du Sacré-Cœur de Montréal (HSCM), 5400 boul. Gouin Ouest, Montréal, Québec, H4J 1C5, Canada.

Background: Multiple organ failure can develop after hemorrhagic shock (HS). Uric acid (UA) is released from dying cells and can be pro-inflammatory. We hypothesized that UA could be an alternative mediator of organ apoptosis and inflammation after HS. Read More

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November 2018

Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.

Ir J Med Sci 2018 Nov 30. Epub 2018 Nov 30.

Department of Health Management, Tianjin Medical University General Hospital, Tianjin, People's Republic of China.

Objective: An increased level of serum uric acid (SUA) can be observed in patients with hypothyroidism. Nonetheless, data on the relationship between hyperuricemia and hyperthyroidism was still controversial. Thus, we aimed to analyze the association between Graves' hyperthyroidism and hyperuricemia in Chinese men and women. Read More

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November 2018

Metabolically Healthy or Metabolically Unhealthy Obese HIV-Infected Patients: Mostly a Matter of Age?

Front Endocrinol (Lausanne) 2018 16;9:681. Epub 2018 Nov 16.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, EPE, Porto, Portugal.

Life expectancy of HIV-infected patients has increased with antiretroviral treatment (ART). Chronic diseases associated with aging, including metabolic and cardiovascular diseases are becoming more prevalent in this population. We aimed to evaluate the association of obesity and aging with cardiometabolic comorbidities and metabolic health status among patients with HIV infection. Read More

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November 2018

Gender Difference in the Association Between Uric Acid and Atrial Fibrillation.

Circ J 2018 Nov 30. Epub 2018 Nov 30.

Institute of Regenerative Medicine and Biofunction, Tottori University Graduate School of Medical Science.

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November 2018

Relationship Between Uric Acid, Proteinuria, and Atherogenic Index of Plasma in Renal Transplant Patients.

Authors:
Z Biyik I Guney

Transplant Proc 2018 May 29. Epub 2018 May 29.

Health Science University, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

This study aimed to determine the association of atherogenic index of plasma (AIP) with both hyperuricemia and proteinuria in renal transplant recipients.

Material And Methods: Between the years 2015 and 2017, 61 renal transplant recipients with at least 1 year of follow-up were included in this retrospective cohort study. Uric acid levels of ≥7 mg/dL in men and ≥6 mg/dL in women were accepted as hyperuricemia. Read More

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A simpler diagnostic formula for screening nonalcoholic fatty liver disease.

Clin Biochem 2018 Nov 29. Epub 2018 Nov 29.

Xi'an Medical University, Xi'an, China. Electronic address:

Objective: To increase the accuracy of non-invasive diagnosis of nonalcoholic fatty liver disease (NAFLD), clinical and laboratory NAFLD indicators were integrated into a diagnostic formula.

Methods: A total of 141 patients with clinically diagnosed NAFLD and 30 healthy controls were enrolled. We collected case history, body weight, height and mass index (BMI), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma glutamyl transpeptidase, blood urea nitrogen and blood uric acid (UA), serum creatinine, plasma total cholesterol, triglyceride, low density lipoprotein, glycosylated hemoglobin, fasting plasma glucose, fasting insulin, ultrasonic tests, Fibroscans, and other data. Read More

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November 2018
2 Reads

A zebrafish (danio rerio) model for high-throughput screening food and drugs with uric acid-lowering activity.

Biochem Biophys Res Commun 2018 Nov 29. Epub 2018 Nov 29.

Laboratory of Molecular Developmental Biology, State Key Laboratory of Membrane Biology, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing, China. Electronic address:

With co-treatment of potassium oxonate (PO) and xanthine sodium salt (XSS), a zebrafish larva model of acute hyperuricemia has been constructed for the first time. The results show PO 200 μM + XSS 10 μM, PO 300 μM + XSS 15 μM, and PO 400 μM + XSS 20 μM can significantly increase the level of uric acid in the zebrafish larvae (P < 0.05), the concentrations as described above can be used to construct the zebrafish larvae model of acute hyperuricemia. Read More

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November 2018

Canrenone on cardiovascular mortality in congestive heart failure: Canrenone effects on cardiovascular mortality in patients with congestive heart failure: The coffee-IT study.

Pharmacol Res 2018 Nov 28. Epub 2018 Nov 28.

Medical and Surgery Sciences Department, University of Bologna, Bologna, Italy.

Aim: To evaluate canrenone effects compared to other therapies on cardiovascular mortality in patients with chronic heart failure (CHF) and preserved systolic function after 10 years of evaluation.

Methods: We enrolled 502 patients with CHF and preserved systolic function. Patients were followed with a mean follow-up of 10 years: 166 patients were in therapy with canrenone, while 336 patients were in conventional therapy. Read More

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November 2018

Blockage of macrophage migration inhibitory factor (MIF) suppressed uric acid-induced vascular inflammation, smooth muscle cell de-differentiation, and remodeling.

Biochem Biophys Res Commun 2018 Nov 28. Epub 2018 Nov 28.

Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address:

Hyperuricemia contributes to vascular injury and dysfunction, yet the potential mechanisms are not well understood. Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Given that MIF is able to induce vascular smooth muscle cell (VSMC) de-differentiation (from contractile state to a secretory state), we thus hypothesized that UA-induced vascular injury is via up-regulating of MIF in VSMCs, which enhancing vascular inflammation and VSMC transition. Read More

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November 2018
1 Read

Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy.

Lab Med 2018 Dec 4. Epub 2018 Dec 4.

Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, China.

Objective: To explore whether there was an increased secretion of cystatin C (Cys C) in twin pregnancy.

Methods: Patients with a total of 281 singleton pregnancies (including 38 patients with preeclampsia) and 72 twin pregnancies, as well as 42 patients who were not pregnant, were included in this study. We tested levels of serum Cys C, creatinine, and uric acid, along with the estimated glomerular filtration rate (eGFR), in different groups. Read More

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December 2018
0.489 Impact Factor

The relationship between serum fibroblast growth factor 23, Klotho, and lumbar spine bone mineral density in northern Chinese postmenopausal women.

Menopause 2018 Dec 3. Epub 2018 Dec 3.

Department of Nephrology, General Hospital of Chinese People's Liberation Army, Beijing, China.

Objectives: Changes in serum protein levels of fibroblast growth factor 23 (FGF23) and Klotho resulting from bone metabolism are still controversial. The purpose of this study was to observe the relationship between FGF23 and Klotho serum proteins and lumbar spine bone mineral density (LBMD) in northern Chinese postmenopausal women.

Methods: This was a community-based cross-sectional study carried out in Shenyang, a northern Chinese city. Read More

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December 2018
1 Read

Independent links between plasma xanthine oxidoreductase activity and levels of adipokines.

J Diabetes Investig 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine.

Aims/introduction: Xanthine oxidoreductase (XOR), a rate-limiting and catalyzing enzyme of uric acid formation in the purine metabolism, is involved in an increase in reactive oxygen species. Plasma XOR activity has been shown to be associated with obesity, smoking, liver dysfunction, hyperuricemia, dyslipidemia and insulin resistance.

Materials And Methods: The association between plasma XOR activity measured by using liquid chromatography and mass spectrometry and levels of adipokines, including adiponectin, fatty acid-binding protein 4 (FABP4) and fibroblast growth factor 21 (FGF21), were investigated in 282 subjects (male/female: 126/156) with no medication of the Tanno-Sobetsu Study. Read More

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December 2018
4 Reads

Evaluation of antiproteinuric and hepato-renal protective activities of propolis in paracetamol toxicity in rats.

Nutr Res Pract 2018 Dec 23;12(6):535-540. Epub 2018 Nov 23.

Laboratory Physiology-Pharmacology & Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez 30000, Morocco.

Background/objectives: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats.

Materials And Methods: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg. Read More

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December 2018

AST to ALT ratio and arterial stiffness in non-fatty liver Japanese population:a secondary analysis based on a cross-sectional study.

Lipids Health Dis 2018 Dec 3;17(1):275. Epub 2018 Dec 3.

Department of Immunology and Microbiology, Guiyang College of Traditional Chinese Medicine, 84# ShiDong Road, Guiyang, 550001, Guizhou, China.

Background: Previous studies have revealed that triglyceride to high-density lipoprotein cholesterol (HDL-C) ratio (henceforth TG/HDL-C) is one of the major risk factors for cardiovascular disease, insulin resistance and metabolism syndrome. However, there are fewer investigations of the correlations between the aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio and brachial ankle pulse wave velocity (baPWV). This study was undertaken to investigate the relationship between the AST to ALT ratio and brachial-ankle pulse wave velocity (baPWV) in a Japanese population. Read More

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December 2018
1 Read

Nephromyces encodes a urate metabolism pathway and predicted peroxisomes, demonstrating these are not ancient losses of apicomplexans.

Genome Biol Evol 2018 Nov 30. Epub 2018 Nov 30.

Department of Biological Sciences, University of Rhode Island, Kingston RI, USA.

The Phylum Apicomplexa is a quintessentially parasitic lineage, whose members infect a broad range of animals. One exception to this may be the apicomplexan genus Nephromyces, which has been described as having a mutualistic relationship with its host. Here we analyze transcriptome data from Nephromyces and its parasitic sister taxon, Cardiosporidium, revealing an ancestral purine degradation pathway thought to have been lost early in apicomplexan evolution. Read More

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November 2018
1 Read

Sex-Specific Association between Serum Uric Acid and Elevated Alanine Aminotransferase in a Military Cohort: The CHIEF Study.

Endocr Metab Immune Disord Drug Targets 2018 Nov 29. Epub 2018 Nov 29.

Department of Medicine, Hualien Armed Forces General Hospital, Hualien. Taiwan.

Aim: The study was conducted in order to examine the sex-specific association of serum uric acid (SUA) levels with elevated serum alanine aminotransferase (ALT) in a Taiwanese military cohort.

Methods: We made a cross-sectional examination of the sex-specific relationship using 6728 men and 766 women, aged 18-50 years from a large military cohort in Taiwan. SUA levels within the reference range (<7. Read More

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November 2018
2 Reads

Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro.

Sci Adv 2018 Nov 28;4(11):eaau4602. Epub 2018 Nov 28.

State Key Laboratory of Microbial Resources and Chinese Academy of Sciences (CAS) Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, CAS, Beijing 100101, P.R. China.

A plethora of bacterial allosteric transcription factors (aTFs) have been identified to sense a variety of small molecules. Introduction of a novel aTF-based approach to sense diverse small molecules in vitro will signify a broad series of detection applications. Here, we found that aTFs could interact with their nicked DNA binding sites. Read More

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November 2018

Age and sex-related differences in performance, carcass traits, hemato-biochemical parameters, and meat quality in Japanese quails.

Poult Sci 2018 Nov 29. Epub 2018 Nov 29.

Department of DETO, Section of Veterinary Science and Animal Production, University of Bari Aldo Moro, Valenzano 70010, Bari, Italy.

The effect of sex and age of Japanese quails (Coturnix japonica) on their performance, blood biochemical parameters, carcass traits, and meat quality was evaluated in this experiment. A total of 450, 3-wk-old Japanese quails (225 males and 225 females) were equally divided into six groups (75 birds each) in a 2 × 3 factorial design, including two sex (male and female) and three slaughter ages (5, 6, and 7 wk of age). Each group was subdivided into five replicates each of 15 birds. Read More

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November 2018
1 Read

Risk factors analysis for hyperuricemic nephropathy among CKD stages 3-4 patients: an epidemiological study of hyperuricemia in CKD stages 3-4 patients in Ningbo, China.

Ren Fail 2018 Nov;40(1):666-671

a Beilun People's Hospital & the Beilun Branch of the First Affiliated Hospital of School of Medicine , Zhejiang University , Ningbo , Zhejiang , China.

Objective: Uric acid (UA) is a risk marker of CKD and SUA level in CKD 3-4 patients closely correlates with hyperuricemic nephropathy (HN) morbidity. This study was designed to evaluate the risk factors for HN in CKD 3-4 patients.

Methods: The 461 CKD 3-4 patients were recruited and all patients were divided into three groups (24 h UUA normal, underexeret, and overproduct type groups) according to the 24 h UUA level after receiving low purine food for five days. Read More

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November 2018
4 Reads

Large-Scale Longitudinal Metabolomics Study Reveals Different Trimester-specific Alterations of Metabolites in Relation to Gestational Diabetes Mellitus.

J Proteome Res 2018 Nov 29. Epub 2018 Nov 29.

Despite the increasing research attention paid to gestational diabetes mellitus (GDM) due to its high prevalence, limited knowledge is available about its pathogenesis. In this study, 428 serum samples were collected from 107 pregnant women suffering GDM and 107 matched healthy controls. The non-targeted metabolomics data of maternal serum samples from the first (T1, n = 214) and second trimesters (T2, n = 214) were acquired by using ultra-high performance liquid chromatography coupled with Orbitrap mass spectrometry (MS). Read More

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November 2018
2 Reads

Effect of high uric acid on the disposition of metformin: in vivo and in vitro studies.

Biopharm Drug Dispos 2018 Nov 28. Epub 2018 Nov 28.

Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, 730000, China.

Metformin is always used the baseline antidiabetic therapy of patients with type 2 diabetes mellitus (T2DM) and hyperuricemia. Metformin excreted into urine through active secretion mediated by rOCTs and rMATE1.The aim of this study was to identify the effects of high uric acid on the disposition and its mechanism. Read More

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November 2018
4 Reads

Warm ischemia time and elevated serum uric acid are associated with metabolic syndrome after liver transplantation with donation after cardiac death.

World J Gastroenterol 2018 Nov;24(43):4920-4927

Department of Gastroenterology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.

Aim: To describe the prevalence of posttransplant metabolic syndrome (PTMS) after donation after cardiac death (DCD) liver transplantation (LT) and the pre- and postoperative risk factors.

Methods: One hundred and forty-seven subjects who underwent DCD LT from January 2012 to February 2016 were enrolled in this study. The demographics and the clinical characteristics of pre- and post-transplantation were collected for both recipients and donors. Read More

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November 2018
1 Read

[A prognostic biomarker in amyotrophic lateral sclerosis].

Rinsho Shinkeigaku 2018 Nov 29. Epub 2018 Nov 29.

Emeritus professor, Kitasato University.

Although we currently have two, approved, disease-modifying drugs for the treatment of amyotrophic lateral sclerosis (ALS), we are in disperate need for more efficacious treatment. To aggressively test for newer therapies, we must develop reliable objective biomarkers to supplement clinical outcome measures. Many biomarker candidates have been actively and vigorously investigated. Read More

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November 2018

Production Inhibition and Excretion Promotion of Urate by Fucoidan from in Adenine-Induced Hyperuricemic Mice.

Mar Drugs 2018 Nov 27;16(12). Epub 2018 Nov 27.

College of Food Science & Technology, Guangdong Ocean University, Zhanjiang 524088, China.

This work aims to explore the amelioration of fucoidan on adenine-induced hyperuricemia and hepatorental damage. Adenine-induced hyperuricemic mice were administered with fucoidan, allopurinol and vehicle control respectively to compare the effects of the drugs. Serum uric acid, urea nitrogen, hepatorenal functions, activities of hepatic adenosine deaminase (ADA), xanthine oxidase (XOD), renal urate transporter 1 (URAT1) and NF-κB p65 were assessed. Read More

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November 2018
2 Reads

Acute effect of soy and soy products on serum uric acid concentration among healthy Chinese men.

Asia Pac J Clin Nutr 2018 ;27(6):1239-1242

School of Public Health, Bengbu Medical College, Anhui, China.

Background And Objectives: Soy products are essential to the daily life of the Chinese population. However, the association between soy products and serum uric acid remains unclear. Better understanding of their relationship could provide food choice information for patients with gout. Read More

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January 2018

Characteristics of gout patients according to the laterality of nephrolithiasis: A cross-sectional study using helical computed tomography.

Int J Rheum Dis 2018 Nov 28. Epub 2018 Nov 28.

Department of Internal Medicine, Midorigaoka Hospital, Takatsuki-shi, Japan.

Objective: To clarify the clinical and laboratory characteristics of nephrolithiasis in gout by computed tomography (CT).

Methods: In 350 gout patients, unenhanced CT was performed at the 1st visit to hospital. Calculus density spots exceeding 1 mm in diameter with a CT value >120 Hounsfield units in the kidneys were defined as kidney stones. Read More

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November 2018

Alarmins at the maternal-fetal interface: involvement of inflammation in placental dysfunction and pregnancy complications.

Can J Physiol Pharmacol 2018 Nov 28. Epub 2018 Nov 28.

Universite de Montreal, Obstetrics & Gynecology , 3175 Chemin de la Cote Ste-Catherine , Montreal, Quebec, Canada , H3T1C5.

Inflammation is known to be associated with placental dysfunction and pregnancy complications. Infections are well known to be a cause of inflammation but they are frequently undetectable in pregnancy complications. More recently, the focus has been extended to inflammation of non-infectious origin, namely caused by endogenous mediators known as "damage-associated molecular patterns - DAMPs" or alarmins. Read More

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November 2018

Gender-specific relationship between uric acid levels and prognosis after cerebral venous thrombosis.

Curr Neurovasc Res 2018 Nov 27. Epub 2018 Nov 27.

From the Department of Neurology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province. China.

Background: Uric acid (UA) has been known to play a neuroprotective role in ischemic stroke patients. However, the relationship between UA levels and prognosis in patients with cerebral venous thrombosis (CVT) has not been investigated.

Method: A total of 228 CVT patients were retrospectively identified and were divided into three groups according to UA levels. Read More

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November 2018