Search Our Scientific Publications & Authors

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):491-504. Epub 2019 Jan 28.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Bioquímica. Ciudad de México, México

Scientific evidence has identified that the excessive consumption of products made from high-fructose corn syrup is a trigger for obesity, whose prevalence increased in recent years. Due to the metabolic characteristics of fructose, a rapid gastric emptying is produced, altering signals of hunger-satiety and decreasing the appetite. In addition to the hepatic level during catabolism, triose phosphate is generated and adenosine triphosphate (ATP) is reduced, producing uric acid. Read More

Chin Med J (Engl) 2019 Feb 6. Epub 2019 Feb 6.

Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China.

Background: Accurate estimation of the glomerular filtration rate (GFR) and staging of chronic kidney disease (CKD) are important. Currently, there is no research on the differences in several estimated GFR equations for staging CKD in a large sample of centenarians. Thus, this study aimed to investigate the differences in CKD staging with the most commonly used equations and to analyze sources of discrepancy. Read More

J Cell Physiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.

The phenotypic changes of tubular epithelial cell are hallmark features of renal diseases caused by abnormal uric acid levels. We hereby intend to investigate whether PI3K/p-Akt signaling plays a role in uric-acid induced epithelial-mesenchymal transition process. The normal rat kidney cell line (NRK-52E) was used as a proximal tubular cell model in this study. Read More

Diabetes Metab 2019 Jan 29. Epub 2019 Jan 29.

Division of Clinical Pharmacology, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, and Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Liège, Liège, Belgium. Electronic address:

Patients with type 2 diabetes mellitus (T2DM) are exposed to non-alcoholic fatty liver disease (NAFLD), a comorbidity associated with cardiovascular disease and chronic kidney disease, and which may progress to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Sodium-glucose cotransporter type-2 (SGLT2) inhibitors are glucose-lowering agents that improve glucose control while promoting weight loss and lowering serum uric acid levels. These agents may exert cardiovascular and renal protection in T2DM patients with established cardiovascular disease. Read More

Infect Disord Drug Targets 2019 Jan 27. Epub 2019 Jan 27.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Read More

Exp Ther Med 2019 Feb 5;17(2):1012-1019. Epub 2018 Dec 5.

Department of Dermatology, 'Victor Babes' Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.

Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Read More

Kidney Int Suppl (2011) 2018 Jan 29;8(1):18-25. Epub 2017 Dec 29.

Department of Medicine, American Society of Hypertension Comprehensive Hypertension Center, University of Chicago Medicine, Chicago, Illinois, USA.

Over the past 30 years there have been many complementary therapies developed to achieve glycemic control and have an impact on cardiovascular outcomes, as well as reduce the risk of microvascular disease. The 2 most notable new entries have been the sodium-glucose cotransporter 2 (SGLT2) inhibitors and the glucagon-like peptide-1 (GLP-1) agonists. Both these classes of agents have demonstrated reductions in cardiovascular event rates as well as reductions in blood pressure and weight. Read More

Cell Biosci 2019 17;9:11. Epub 2019 Jan 17.

1Department of Traditional Chinese Medicine, Renmin Hospital of Wuhan University, No. 99 Zhangzhidong Road, Wuhan, 430060 China.

Background: The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.

Methods: Rat models of UAN were induced by adenine and potassium oxonate. Enzyme-linked immunosorbent assay (ELISA) was performed to assess inflammation factor in serum and supernatant. Read More

Environ Sci Pollut Res Int 2019 Jan 21. Epub 2019 Jan 21.

Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Recent studies have demonstrated that bisphenol A (BPA) has an adverse or toxic effect on the kidney. This study was designed to evaluate the ability of quercetin (QUER) to prevent BPA-induced mitochondrial dysfunction. Thirty-two healthy adult male Wistar rats were randomly divided into four groups, as follows: control group (olive oil), BPA group (250 mg/kg), BPA þ QUER group (250 mg/kg + 75 mg/kg), and QUER group (75 mg/kg). Read More

Am J Physiol Renal Physiol 2019 Jan 16. Epub 2019 Jan 16.

Nephrology, Shanghai East Hospital, Tongji University School of Medicine, China.

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are serine/threonine kinases and function as regulators of cellular proliferation and differentiation. Recently, we demonstrated that inhibition of ERK1/2 alleviates the development and progression of hyperuricemia nephropathy (HN). However, its potential roles in uric acid-induced tubular epithelial-mesenchymal transition (EMT) and tubular epithelial cell injury are unknown. Read More

Nephrology (Carlton) 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid and the risk of acute kidney injury (AKI) and mortality remains unresolved in hospitalized patients.

Methods: Data from 18,444 hospitalized patients were retrospectively reviewed. Read More

Evid Based Complement Alternat Med 2018 13;2018:7602962. Epub 2018 Dec 13.

Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

. Hypoxia plays a significant role in the progression of chronic kidney disease (CKD) and renal fibrosis. In China, Chinese herbal medicine has been widely used to treat CKD. Read More

Clin Nephrol 2019 Mar;91(3):180-186

Aims: To investigate the clinicopathological features and outcomes of adefovir dipivoxil (ADV)-related renal impairment in Chinese patients.

Materials And Methods: Clinical, pathological, and follow-up data from 15 patients with ADV-related renal impairment were studied. Proximal renal tubular dysfunction (PRTD) was defined by the presence of at least two of the following four abnormalities: hypophosphatemia, hypouricemia, nondiabetic glucosuria, and proteinuria. Read More

Respir Med Case Rep 2019 23;26:142-145. Epub 2018 Dec 23.

Pulmonary and Critical Care Medicine, Marshall University School of Medicine, Huntington, WV, USA.

Rasburicase is a recombinant urate-oxidase enzyme and is a very important medication for tumor lysis syndrome. Methemoglobinemia and hemolysis are known side effects of rasburicase that result from oxidative stress caused by hydrogen peroxide, a byproduct generated during the breakdown of uric acid to allantoin. Patients with G6PD deficiency have a decreased tolerance to oxidative stress and are therefore at a greater risk of hemolysis and methemoglobinemia with rasburicase. Read More

Postepy Kardiol Interwencyjnej 2018 11;14(4):399-412. Epub 2018 Dec 11.

Department of Cardiovascular Sciences, Sapienza University, Rome, Italy.

Introduction: Previous studies have suggested a relationship between serum uric acid and contrast-induced nephropathy (CIN).

Aim: We performed an updated review and a meta-regression analysis to assess whether serum uric acid is associated with CIN or there exists any relationship between serum uric acid and other risk factors for CIN.

Material And Methods: We searched PubMed, Embase and Cochrane databases and reviewed cited references up to July 31, 2018 to identify relevant studies. Read More

Clin Interv Aging 2019 20;14:27-32. Epub 2018 Dec 20.

Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China,

Introduction: Few studies focused on mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients. This study was conducted to survey the prevalence, the potent risk factors of MCI in MHD patients, and further observe the progress of MCI in a period of 6 months.

Methodology: Mini-Mental State Examination, and Montreal Cognitive Assessment were used to assess cognitive condition. Read More

Biomed Pharmacother 2018 Dec 20;111:162-168. Epub 2018 Dec 20.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address:

Uric acid metabolic disorder is considered to be the main pathogenesis of uric acid nephropathy (UN). Smilax glabra Roxb. is a traditional Chinese herb which has been used in the treatment of gout, but the mechanism was unclear. Read More

Transplant Proc 2018 Dec 9;50(10):4099-4101. Epub 2018 Mar 9.

Private practice, Murrieta, California. Electronic address:

This case describes a female patient with polyarticular tophaceous gout who was given transplant immunosuppressant medications. The 36-year-old was treated for Wilms tumor at 3 years of age by operative removal of 1 kidney, chemotherapy, and radiotherapy. At age 19, the patient was diagnosed with cardiomyopathy attributed to prior chemotherapy and radiotherapy. Read More

Transplant Proc 2018 Dec 18;50(10):3392-3396. Epub 2018 Apr 18.

Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, UdeLaR, Montevideo, Uruguay.

Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correcting these factors in native kidneys slows the progression of chronic kidney disease. The aim of this study was to analyze the association between the control of non-immunological factors and the annual decline of GFR. Read More

Transplant Proc 2018 Dec;50(10):3356-3360

Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: BK virus allograft nephropathy (BKVAN) is a graft-threatening complication after kidney transplantation. Current consensus regarding the prevention of BKVAN is to screen for BK viremia and to treat sustained BK viremia through reducing immunosuppression. This study assessed the effect of conversion from mycophenolates to mizoribine (MZR) on the prevention of BK viremia in kidney transplant recipients. Read More

J Occup Environ Med 2018 Dec 18. Epub 2018 Dec 18.

Center for Health, Work & Environment, Colorado School of Public Health, University of Colorado, Aurora, CO (Cecilia J Sorensen, Jaime Butler-Dawson, Miranda Dally, Lyndsay Krisher, Liliana Tenney, Lee S. Newman); Department of Emergency Medicine, University of Colorado School of Medicine, Aurora, CO (Cecilia J Sorensen, Jay Lemery); Colorado Consortium on Climate Change and Human Health, University of Colorado, Aurora, CO (Cecilia J Sorensen, Jaime Butler-Dawson, Miranda Dally, Lyndsay Krisher, Richard J. Johnson, Jay Lemery, Liliana Tenney, Lee S. Newman); Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Aurora, CO (Jaime Butler-Dawson, Miranda Dally, Lyndsay Krisher, Liliana Tenney, Lee S. Newman); Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO (Benjamin R. Griffin, Richard J. Johnson); Pantaleon, Guatemala (Claudia Asensio); Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine, University of Colorado, Aurora, CO (Lee S. Newman).

Objective: Identify early biomarkers and mechanisms of acute kidney injury in workers at risk of developing chronic kidney disease of unknown origin (CKDu).

Methods: We assessed cross-shift changes in kidney function and biomarkers of injury in 105 healthy sugarcane workers. We obtained pre-harvest clinical data as well as daily environmental, clinical, and productivity data for each worker. Read More

Urologiia 2018 Dec(5):146-152

Research Institute for Uronephrology and Human Reproductive Health, I.M. Sechenov First MSMU of Minzdrav of Russia MSU Moscow, Russia.

Urolithiasis is a widespread chronic disease; its prevalence has been steadily increasing over the past 50 years. Urolithiasis accounts for a large proportion urologic diseases, exceeded only by urinary tract infections and diseases of the prostate. Urate urolithiasis refers to a type of urolithiasis, characterized by the formation of kidney stones consisting of uric acid or its salts. Read More

Am J Physiol Renal Physiol 2018 Dec 19. Epub 2018 Dec 19.

Nephrology, Shanghai East Hospital, Tongji University School of Medicine, China.

Hyperuricemia has been identified as an independent risk factor for chronic kidney disease (CKD) and is associated with the progression of kidney diseases. It remains unknown whether enhancer of zeste homolog 2 (EZH2), a histone H3 lysine 27 methyltransferase, can regulate metabolism of serum uric acid and progression of renal injury induced by hyperuricemia. In this study, we demonstrated that blockade of EZH2 with 3-DZNeP, a selective EZH2 inhibitor, or silencing of EZH2 with siRNA inhibited uric acid-induced renal fibroblast activation and phosphorylation of Smad3, epidermal growth factor receptor (EGFR) and extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) in cultured renal fibroblasts. Read More

J Agric Food Chem 2018 Dec 18. Epub 2018 Dec 18.

Gout that caused by hyperuricemia affects human health seriously and more efficient drugs are urgently required clinically. In this study, a novel peptide named RDP1 (AAAAGAKAR, 785.91 Da) was identified from the extract of shelled fruits of Oryza Sativa. Read More

Acta Biomed 2018 Dec 17;89(9-S):76-80. Epub 2018 Dec 17.

Pediatric Emergency Unit, University Hospital of Parma, Maternal and Infant Department, Parma, Italy.

Background And Aim Of The Work: Historical studies have demonstrated that the prevalence of symptomatic nephrolithiasis is higher in patients with inflammatory bowel disease (IBD), compared to general population. The aim of the review was to analyze literature data in order to identify the main risk conditions described in literature and the proposed treatment.

Methods: A research on the databases PubMed, Medline, Embase and Google Scholar was performed by using the keywords "renal calculi/lithiasis/stones" and "inflammatory bowel diseases". Read More

Nephrology (Carlton) 2018 Dec 18. Epub 2018 Dec 18.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China.

Background: Chronic kidney disease (CKD) is a worldwide public health problem. Although accumulated data suggested that probiotic supplements played roles in CKD, the results remained controversial. Here we performed a meta-analysis to assess the effects of probiotic supplements on the CKD progression. Read More

Biomed Pharmacother 2019 Jan 26;109:1802-1808. Epub 2018 Nov 26.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Accumulating evidences indicated that hyperuricemia was an independent risk factor for kidney diseases and contributed to kidney fibrosis. Preventing and treating renal fibrosis was an optimal treatment for hyperuricemia-induced kidney diseases. In the study, pterostilbene (PTE) as a bioactive component of blueberries was confirmed to possess lowering serum uric acid and renal protective functions by the decrease of serum creatinine, BUN, urine albumin, and urine albumin-to-creatinine ratio (uACR) in a mouse model of hyperuricemic nephropathy (HN). Read More

PLoS One 2018 14;13(12):e0209156. Epub 2018 Dec 14.

Department of Transplantation Surgery, Severance Hospital, Yonsei University Health System, Seoul, South Korea.

Background: Serum uric acid (UA) level has been reported to be associated with chronic allograft nephropathy and graft failure in patients who undergo kidney transplantation (KT). However, the role of serum UA level in renal graft survival remains controversial.

Objective: This study aimed to investigate the effect of mean serum UA level during two different post-KT periods on long-term renal graft outcomes in a large population cohort in which living donor KT prevails. Read More

Int J Nanomedicine 2018 21;13:7765-7770. Epub 2018 Nov 21.

Department of Physics and Astronomy, College of Science, King Saud University, Riyadh, Saudi Arabia,

Introduction: This study aimed to evaluate the nephrotoxicity caused by gold nanoparticles (GNPs) and investigate the potential roles of quercetin (Qur) and arginine (Arg) in mitigating the inflammatory kidney damage and dysfunction and inhibiting the toxicity induced by GNPs in rats.

Methods: Kidney function was assessed using various serum biomarkers, including blood urea nitrogen (BUN), uric acid (URIC), and creatinine (CR), while toxicity was evaluated by measuring the biomarkers glutathione (GSH) and malondialdehyde (MDA) in kidney tissues.

Results: Administration of GNPs to the rats severely affected the serum kidney biomarkers, as confirmed by the notable increases in BUN, URIC, and CR. Read More

Kidney Blood Press Res 2018 7;43(6):1852-1864. Epub 2018 Dec 7.

Department of Nephrology, the Second Xiangya Hospital, Central South University, Key laboratory of Kidney disease and Blood Purification in Hunan Province, Changsha,

Background/aims: There is an increasing risk of end-stage renal disease (ESRD) among Asian people with immunoglobulin A nephropathy (IgAN). A computer-aided system for ESRD prediction in Asian IgAN patients has not been well studied.

Methods: We retrospectively reviewed biopsy-proven IgAN patients treated at the Department of Nephrology of the Second Xiangya Hospital from January 2009 to November 2013. Read More

Curr Med Chem 2018 Dec 10. Epub 2018 Dec 10.

Kidney Research Laboratory, Division of Nephrology, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041. China.

Hyperuricemia, defined as the presence of elevated serum uric acid (sUA), could lead to urate deposit in joints, tendons, kidney and other tissues. Hyperuricemia as an independent risk factor was common in patients during the causation and progression of kidney disease. Uric acid is a soluble final product of endogenous and dietary purine metabolism, which is freely filtered in kidney glomeruli where approximately 90% of filtered uric acid is reabsorbed. Read More

Angiology 2018 Dec 9:3319718816206. Epub 2018 Dec 9.

1 Department of Cardiology, Tianjin Chest Hospital, Tianjin, China.

Background:: Low serum albumin, high blood urea nitrogen (BUN), and uric acid are regarded closely related to the incidence of contrast-induced nephropathy (CIN), whereas it remains unclear whether they can function as predictors of CIN onset. The objective of this systematic review and meta-analysis was to explore the association between abovementioned indicators and CIN incidence rate in patients receiving coronary angiography (CAG) and/or intervention.

Methods:: Clinical studies were retrieved from the electronic databases of PubMed, EMBASE, Google Scholar, Clinical Trials, and ScienceDirect from their inception to July 13, 2018. Read More

J Hypertens 2019 Jan;37(1):167-174

Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Denver, Aurora, Colorado, USA.

Objective: This study was conducted to identify whether higher fasting blood glucose levels is predictive of hypertension by a large-scale longitudinal design.

Methods: We conducted a retrospective 5-year cohort study using the data from 13 201 Japanese individuals who underwent annual medical examinations in 2004 and were reevaluated 5 years later. This study included individuals without diabetes or hypertension between ages 30 and 85 years in 2004. Read More

Transplant Proc 2018 Dec 29;50(10):3376-3380. Epub 2018 May 29.

Health Science University, Konya Research and Training Hospital, Nephrology Department, Konya, Turkey.

This study aimed to determine the association of atherogenic index of plasma (AIP) with both hyperuricemia and proteinuria in renal transplant recipients.

Material And Methods: Between the years 2015 and 2017, 61 renal transplant recipients with at least 1 year of follow-up were included in this retrospective cohort study. Uric acid levels of ≥7 mg/dL in men and ≥6 mg/dL in women were accepted as hyperuricemia. Read More

Biochem Biophys Res Commun 2019 Jan 28;508(2):440-444. Epub 2018 Nov 28.

Department of Cardiology, Second Affiliated Hospital of Dalian Medical University, Dalian, 116011, China. Electronic address:

Hyperuricemia contributes to vascular injury and dysfunction, yet the potential mechanisms are not well understood. Uric acid (UA) has been found to stimulate macrophage migration inhibitory factor (MIF) up-regulation in renal tubules from rats subjected to UA-induced nephropathy. Given that MIF is able to induce vascular smooth muscle cell (VSMC) de-differentiation (from contractile state to a secretory state), we thus hypothesized that UA-induced vascular injury is via up-regulating of MIF in VSMCs, which enhancing vascular inflammation and VSMC transition. Read More

Nutr Res Pract 2018 Dec 23;12(6):535-540. Epub 2018 Nov 23.

Laboratory Physiology-Pharmacology & Environmental Health, Faculty of Sciences Dhar El Mehraz, University Sidi Mohamed Ben Abdallah, Fez 30000, Morocco.

Background/objectives: Propolis has a rich source of bioactive compounds and has renal and hepatic protective properties. The purpose of this study was to investigate the beneficial effect of hydro-ethanolic extract of propolis against paracetamol-induced liver damage and impairment of kidney function, as well as hematological changes in rats.

Materials And Methods: Six groups of rats were used; the first group was served as a control; the second and third groups were treated by propolis extract at a dose of 50 and 100 mg/kg. Read More

Ren Fail 2018 Nov;40(1):666-671

a Beilun People's Hospital & the Beilun Branch of the First Affiliated Hospital of School of Medicine , Zhejiang University , Ningbo , Zhejiang , China.

Objective: Uric acid (UA) is a risk marker of CKD and SUA level in CKD 3-4 patients closely correlates with hyperuricemic nephropathy (HN) morbidity. This study was designed to evaluate the risk factors for HN in CKD 3-4 patients.

Methods: The 461 CKD 3-4 patients were recruited and all patients were divided into three groups (24 h UUA normal, underexeret, and overproduct type groups) according to the 24 h UUA level after receiving low purine food for five days. Read More

Clin Exp Nephrol 2018 Nov 26. Epub 2018 Nov 26.

Miho Clinic, Jikei University School of Medicine, Shin-Osaki Kangyo Bldg. 2F, 1-6-4, Osaki, Shinagawa-ku, 141-0032, Tokyo, Japan.

This communication provides a current overview on the renal protective effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors in diabetics. Following the epoch-making publications, the CANVAS Program and the EMPA-REG OUTCOME trial, numerous literature has discussed the mechanisms by which SGLT2 inhibition exerts its cardio-renal protective effects. Some of them reached agreement, while others did not. Read More

Urolithiasis 2019 Feb 26;47(1):107-113. Epub 2018 Nov 26.

Nephrology Division, NYU Langone Health, New York, NY, USA.

Careful phenotyping of patients to classify those with kidney stones has a long and important history in revealing the chemical basis for stone formation. Advances in our genetic understanding of kidney stones will lead to incredible insights regarding the pathophysiology of this common disorder. At this time, both evaluation of urine chemistry and genotyping of patients are extremely useful in the setting of a university and research-based kidney stone clinic. Read More

J Ayurveda Integr Med 2018 Nov 16. Epub 2018 Nov 16.

M.M. College of Pharmacy, M.M. University, Mullana-Ambala, Haryana 133207, India. Electronic address:

Background: Diabetic nephropathy (DN) is the foremost cause of morbidity and has become the most recurrent cause of end-stage renal disease among diabetic patients. Thus, agents having antidiabetic effect along with safety potential in the kidneys would have a higher remedial value.

Objective: The present study aimed to investigate possible protective effect of homeopathic preparation of Cephalandra indica Mother tincture, 6C and 30 C potencies on DN in Wistar rats. Read More

Cureus 2018 Sep 11;10(9):e3282. Epub 2018 Sep 11.

Nephrology Unit, Howard University Hospital, Washington, D.C., USA.

Mesoamerican nephropathy (MeN), formerly called chronic kidney disease of unknown cause (CKDu), refers to chronic kidney disease (CKD) that presents in young and middle-aged Central Americans in the absence of any clear etiology. MeN is a relatively new diagnosis with rapidly rising prevalence in specific regions of El Salvador and Nicaragua, Guatemala, and Costa Rica. It is seldom associated with hyperuricemia. Read More

Sci Rep 2018 Nov 12;8(1):16707. Epub 2018 Nov 12.

School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China.

Siwei Jianghuang Decoction Powder (SWJH) documented originally in the Four Medical Tantras-Blue Glaze exhibited beneficial effects on diabetic nephropathy (DN) via combined synergistically action of multiple formula components including Curcumae longae Rhizoma, Berberidis dictyophyllae Cortex, Phyllanthi Fructus and Tribuli Fructus. This study investigated the effects of SWJH on DN in db/db mice and possible underlying mechanisms. The ten weeks old db/db mice treated with SWJH by intra-gastric administration once a day for 8 weeks. Read More

Pak J Biol Sci 2018 Jan;21(7):348-358

Background And Objective: Dyslipidemia is a major health problem that may lead to cardiovascular diseases (CVDs). In the present research, a biological experiment was run on dyslipidemic rats to study the health benefits of the volatile oils (VOs) of fennel and rosemary in its original and nano-form using chitosan as carrier.

Materials And Methods: Rats were divided into 6 groups; normal control, dyslipidemic control and 4 test groups with dyslipidemia and treated by VOs of fennel and rosemary and their respective nano-forms separately. Read More

BMC Nephrol 2018 Nov 8;19(1):315. Epub 2018 Nov 8.

Division of Renal Diseases and Hypertension, University of Colorado, Denver, CO, USA.

Background: Fructose intake, mainly as table sugar or high fructose corn syrup, has increased in recent decades and is associated with increased risk for kidney stones. We hypothesized that fructose intake alters serum and urinary components involved in stone formation.

Methods: We analyzed a previously published randomized controlled study that included 33 healthy male adults (40-65 years of age) who ingested 200 g of fructose (supplied in a 2-L volume of 10% fructose in water) daily for 2 weeks. Read More

Exp Clin Endocrinol Diabetes 2019 Jan 5;127(1):50-55. Epub 2018 Nov 5.

Department of Endocrine, Peking University People's Hospital, Beijing, China.

Objective: To identify correlations of bone mineral density (BMD) and bone metabolism indices with the urine albumin to creatinine ratio (ACR) as an indicator of nephropathy in Chinese patients with type 2 diabetes (T2D).

Methods: In this retrospective analysis, 297 patients with T2D were divided into 3 groups according to the urine ACR. Patients' data were analyzed to identify associations of general conditions, blood glucose level, lipid levels, and uric acid level with BMD and bone metabolism indices. Read More

Cell Physiol Biochem 2018 5;50(5):1794-1803. Epub 2018 Nov 5.

The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, Hangzhou, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou,

Background/aims: To investigate the relationship between elevated serum procalcitonin (PCT) and renal function in hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).

Methods: HBV-ACLF patients (n = 201) presenting to the State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University, from January 2013 to November 2016 were categorized into three groups according to serum PCT levels: (i) normal group (n = 74) had PCT of ≤ 0.5 ng/mL; (ii) elevated group (n = 85) had PCT in the range 0. Read More

Am J Nephrol 2018 2;48(5):339-348. Epub 2018 Nov 2.

University of Colorado, Renal Diseases and Hypertension, Aurora, Colorado, USA.

Background: Heat stress and rhabdomyolysis are major risk factors for the occurrence of repeated acute kidney injury in workers exposed to heat and strenuous work. These episodes, in turn, may progress to chronic kidney disease.

Objective: The purpose of this study was to test the effect of allopurinol (AP) and sodium bicarbonate on the kidney injury induced by recurrent heat stress dehydration with concomitant repeated episodes of rhabdomyolysis. Read More

Environ Sci Pollut Res Int 2019 Jan 1;26(1):179-187. Epub 2018 Nov 1.

Student Research committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Curcumin (Cur) effects on renal injury induced by zinc oxide nanoparticles (NZnO) in rats were investigated. NZnO at a dose of 50 mg/kg for 14 days was administered to rats as intoxicated group. In protection group, Cur at a dose of 200 mg/kg was administered for 7 days prior to NZnO treatment and followed by concomitant administration of NZnO for 14 days. Read More

J Nephrol 2018 Oct 31. Epub 2018 Oct 31.

Tianjin University of Traditional Chinese Medicine, Tianjin, 300193, China.

The abnormal metabolism of uric acid results in many disease such as chronic kidney disease, hyperuricemia, nephrolithiasis, gout, hypertension, vascular disease and so on. Serum uric acid levels are maintained by the balance between production and elimination. There are many factors that maintain the balance of serum uric acid. Read More

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1050-1056

Department of Nephrology, Owaisi Hospital, Deccan College of Medical Sciences, Hyderabad, Telangana, India.

Hyperuricemia [serum uric acid (SUA) >7.0 mg/dL] which is common in chronic renal diseases is associated with augmented vascular events. In addition to nonpharmacological therapy, hypouricosuric drugs reduce UA levels. Read More