6,209 results match your criteria Uric Acid Nephropathy


Dual actions of norathyriol as a new candidate hypouricaemic agent: uricosuric effects and xanthine oxidase inhibition.

Eur J Pharmacol 2019 Apr 19. Epub 2019 Apr 19.

Biomedical Engineering Research Center, Kunming Medical University, Kunming, 650500, China. Electronic address:

Hyperuricaemia, which results from the overproduction and underexcretion of uric acid, has been linked with chronic renal dysfunction, cardiovascular diseases, diabetes and metabolic syndrome. However, available clinical drugs cannot simultaneously target the production and excretion of uric acid. Norathyriol, a natural xanthone, was expected to have the dual actions. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.04.034DOI Listing

Uroflowmetry alterations in patients with autosomal dominant polycystic kidney disease.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2734-2743

Department of Translational and Precision Medicine, UOC Nephrology, Sapienza University of Rome, Rome, Italy.

Objective: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a heterogeneous inherited disease characterized by renal and extrarenal manifestations with progressive fluid-filled cyst development leading to end-stage renal disease. Our aim was to evaluate the prevalence of obstructive urological disease in ADPKD patients and possible associations with endothelial dysfunction, nutritional, metabolic and inflammatory markers.

Patients And Methods: The study included ADPKD patients and control group, who carried out uroflowmetry, an assessment of renal function, metabolic and nutritional parameters and an evaluation of endothelial dysfunction and atherosclerotic markers, such as Renal Resistive Index (RRI), Intima-Media Thickness (IMT) and Flow-Mediated Dilation (FMD). Read More

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http://www.europeanreview.org/article/17546
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http://dx.doi.org/10.26355/eurrev_201904_17546DOI Listing
April 2019
1 Read

Prevalence and Risk Factors of BK Viremia and Clinical Impact of BK Virus Surveillance on Outcomes in Kidney Transplant Recipients: A Single-Center Cross-Sectional Study.

Exp Clin Transplant 2019 Apr 17. Epub 2019 Apr 17.

From the Urology Institute of Capital Medical University, Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Beijing, China.

Objectives: BK virus is a polyomavirus that can cause nephropathy and graft loss after kidney transplant. The aim of our study was to screen the BK viremia prevalence, to understand the value of the inter-vention for BK virus nephropathy, and to determine the risk factors associated with BK viremia after kidney transplant in our center.

Materials And Methods: Our retrospective cross-sectional study included 91 adult kidney transplant recipients who were seen between 2015 and 2017 and who had follow-up from 1 month to over 2 years. Read More

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http://dx.doi.org/10.6002/ect.2018.0262DOI Listing

The Role of Uric Acid in Acute Kidney Injury.

Nephron 2019 Apr 16:1-9. Epub 2019 Apr 16.

Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA.

Studies have demonstrated the presence of a strong association between serum uric acid (SUA) and acute kidney injury (AKI) consistently across several disease models. Exposure to SUA at different time periods and concentrations has reliably resulted in AKI whether assessed by conventional or novel biomarkers or by kinetic estimated glomerular filtration rate (KeGFR) engineered for non-steady dynamic states. In experimental models, moderate hyperuricemia was associated with an absence of intrarenal crystals, manifestation of tubular injury, macrophage infiltration, and increased expression of inflammatory mediators that were attenuated with uric acid lowering therapy with rasburicase, a recombinant urate oxidase. Read More

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http://dx.doi.org/10.1159/000499939DOI Listing
April 2019
1 Read

Benzbromarone as a possible cause of acute kidney injury in patients with urolithiasis: Two case reports.

Medicine (Baltimore) 2019 Apr;98(15):e15214

Department of Nephrology, China-Japan Friendship Hospital, Beijing.

Rationale: Reports of acute kidney injury (AKI) associated with benzbromarone use in patients with hyperuricemia (HUA) are rare so far.

Patient Concerns: We describe 2 unique clinical patterns in which benzbromarone was a possible cause of AKI following self-medication for HUA. In case 1, a 45-year-old man developed AKI after taking 100 mg of benzbromarone. Read More

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http://dx.doi.org/10.1097/MD.0000000000015214DOI Listing
April 2019
4 Reads

High-Resistant Starch, Low-Protein Flour Intervention on Patients With Early Type 2 Diabetic Nephropathy: A Randomized Trial.

J Ren Nutr 2019 Apr 11. Epub 2019 Apr 11.

Department of Nutrition, Shandong Provincial Hospital, Jinan, China; Department of Nutrition and Food Hygiene, School of Public health, Shandong University, Jinan, China. Electronic address:

Objective: The objective of this study is to explore the effect of high-resistant starch (RS), low-protein flour as a source of RS on patients with early type 2 diabetic nephropathy (DN) through the clinical intervention trial.

Design: This was a single center, randomized, comparative, open-label trial. Seventy-five patients with early DN, aged 18 to 80 y, were recruited and randomly assigned to two groups. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10512276183028
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http://dx.doi.org/10.1053/j.jrn.2018.12.005DOI Listing
April 2019
6 Reads

Elevated Serum Uric Acid Is Associated With Greater Risk for Hypertension and Diabetic Kidney Diseases in Obese Adolescents With Type 2 Diabetes: An Observational Analysis From the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Study.

Diabetes Care 2019 Apr 9. Epub 2019 Apr 9.

University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO.

Objective: Elevated serum uric acid (SUA) is increasingly recognized as a risk factor for kidney disease in adults with diabetes, but data in youth are limited. We hypothesized that elevated SUA predicts development of elevated urinary albumin excretion (UAE) and hypertension over time in teens with type 2 diabetes (T2D).

Research Design And Methods: Serum creatinine, cystatin C, SUA, and the urine albumin-to-creatinine ratio (UACR) were assessed in 539 obese youth, ages 12-17 years, with T2D duration <2 years at baseline in the Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) study. Read More

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http://dx.doi.org/10.2337/dc18-2147DOI Listing
April 2019
1 Read
8.420 Impact Factor

3'--β-d-glucopyranosyl-α,4,2',4',6'-pentahydroxy-dihydrochalcone, from Bark of Prevents Diabetic Nephropathy via Inhibiting Protein Glycation in STZ-Nicotinamide Induced Diabetic Mice.

Molecules 2019 Mar 28;24(7). Epub 2019 Mar 28.

Green Chemistry Research Laboratory, School of Chemical Engineering and Extractive Industries, National Polytechnic Institute, Av. Instituto Politécnico Nacional S/N, Unidad Profesional Adolfo Lopez Mateos, Ciudad de México CP 07708, Mexico.

Previous studies have shown that accumulation of advanced glycation end products (AGEs) can be the cause of diabetic nephropathy (DN) in diabetic patients. Dihydrochalcone 3'--β-d-glucopyranosyl α,4,2',4',6'-pentahydroxy⁻dihydrochalcone () is a powerful antiglycation compound previously isolated from . The aim was to investigate whether () was able to protect against diabetic nephropathy in streptozotocin (STZ)-induced diabetic mice, which displayed renal dysfunction markers such as body weight, creatinine, uric acid, serum urea, total urinary protein, and urea nitrogen in the blood (BUN). Read More

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http://dx.doi.org/10.3390/molecules24071214DOI Listing
March 2019
1 Read

Long-Term Adherence to Medications in Secondary Prevention of Urinary Tract Stones.

J Endourol 2019 Mar 26. Epub 2019 Mar 26.

Rabin medical center, urology , Keren kayemet st , Petach Tikva, Israel , 65222 ;

Purpose: To reduce the high recurrence rate of nephrolithiasis, patients are routinely prescribed secondary chemoprevention therapy with alkali citrate (Alkasolve® , Sam-On Ltd., Israel) for uric acid stones and hypocitraturia or Hydrochlorthiazide (Disothiazide®; Dexcel Ltd., Israel) for hypercalciuria. Read More

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http://dx.doi.org/10.1089/end.2019.0040DOI Listing
March 2019
1 Read

Zinc alpha 2 glycoprotein as an early biomarker of diabetic nephropathy in patients with type 2 diabetes mellitus.

J Bras Nefrol 2019 Mar 18. Epub 2019 Mar 18.

Faculty of Medicine, Clinical Pathology Department, Zagazig University, Egypt.

Introduction: Although microalbuminuria remains the gold standard for early detection of diabetic nephropathy (DN), it is not a sufficiently accurate predictor of DN risk. Thus, new biomarkers that would help to predict DN risk earlier and possibly prevent the occurrence of end-stage kidney disease are being investigated.

Objective: To investigate the role of zinc-alpha-2-glycoprotein (ZAG) as an early marker of DN in type 2 diabetic (T2DM) patients. Read More

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http://dx.doi.org/10.1590/2175-8239-JBN-2018-0200DOI Listing
March 2019
1 Read

Mid-arm circumference, body fat, nutritional and inflammatory biomarkers, blood glucose, dialysis adequacy influence all-cause mortality in hemodialysis patients: A prospective cohort study.

Medicine (Baltimore) 2019 Mar;98(12):e14930

School of Nutrition and Health Sciences, Taipei Medical University.

Hemodialysis patients are at the high risk for morbidity and mortality. Evaluation and management of body composition and biochemical values are important to improve dialysis outcomes. We aimed to examine the effects of the mid-arm circumference, body fat, nutritional and inflammatory biomarkers, blood glucose, and dialysis adequacy on the mortality. Read More

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http://dx.doi.org/10.1097/MD.0000000000014930DOI Listing
March 2019
2 Reads
5.723 Impact Factor

Hyperuricemia and its related histopathological features on renal biopsy.

BMC Nephrol 2019 Mar 18;20(1):95. Epub 2019 Mar 18.

Renal Department and Nephrology Institute, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, 610072, China.

Background: Hyperuricemia (HUA) is very common in chronic kidney disease (CKD). HUA is associated with an increased risk of cardiovascular events and accelerates the progression of CKD. Our study aimed to explore the relationship between baseline serum uric acid levels and renal histopathological features. Read More

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http://dx.doi.org/10.1186/s12882-019-1275-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423852PMC
March 2019
2 Reads
1.520 Impact Factor

[Association between dyslipidemia and carotid plaque incidence in a research group: a prospective cohort study].

Zhonghua Liu Xing Bing Xue Za Zhi 2019 Mar;40(3):341-345

Institute of Geriatrics, Chinese People's Liberation Army General Hospital, Beijing 100853, China; Beijing Key Laboratory of Research on Aging and Related Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China; State Key Laboratory of Kidney Disease, Chinese People's Liberation Army General Hospital, Beijing 100853, China; National Clinical Research Center for Geriatrics Diseases, Chinese People's Liberation Army General Hospital, Beijing 100853, China.

To assess the association and intensity of baseline dyslipidemia with the incidence of carotid plaque in a researchers group in China. A total of 716 researchers were enrolled in this prospective cohort study. Dyslipidemia was assessed in 2010. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0254-6450.2019.03.016DOI Listing
March 2019
1 Read

Dual actions on gout flare and acute kidney injury along with enhanced renal transporter activities by Yokuininto, a Kampo medicine.

BMC Complement Altern Med 2019 Mar 12;19(1):57. Epub 2019 Mar 12.

The K-herb Research Center, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, Republic of Korea.

Background: Prolonged hyperuricemia is associated with kidney disease or gouty arthritis. Whether Yokuininto, a commercially available Kampo medicine that has been used for osteoarthritis or rheumatoid arthritis, can exhibit anti-hyperuricemic and inflammatory effects remains elusive. In the present study, Yokuininto exerts multiple homeostatic action on serum uric acid (sUA) levels by blocking pro-inflammatory cytokine activities and inducing uricosuric function with anti-renal injury functions. Read More

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http://dx.doi.org/10.1186/s12906-019-2469-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6419507PMC
March 2019
1 Read

Acute Uric Acid Nephropathy following Epileptic Seizures: Case Report and Review.

Case Rep Nephrol 2019 4;2019:4890287. Epub 2019 Feb 4.

Division of Pulmonary and Critical Care Medicine, Pikeville Medical Center, USA.

Acute hyperuricemia most commonly occurs in patients who experience tumor lysis syndrome. Hyperuricemia along with other electrolyte abnormalities like hyperkalemia, hypocalcemia, and hyperphosphatemia leads to acute kidney injury (AKI) due to acute uric acid nephropathy which is associated with significant morbidity. High risk patients are thus closely monitored for signs of these laboratory abnormalities. Read More

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http://dx.doi.org/10.1155/2019/4890287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6378786PMC
February 2019
2 Reads

Disposable Nonenzymatic Uric Acid and Creatinine Sensors Using PAD Coupled with Screen-Printed Reduced Graphene Oxide-Gold Nanocomposites.

Int J Anal Chem 2019 3;2019:3457247. Epub 2019 Feb 3.

Organic Synthesis, Electrochemistry & Natural Product Research Unit, Department of Chemistry, Faculty of Science, King Mongkut's University of Technology Thonburi, 126 Pracha-utid Road, Bang Mod, Thungkru, Bangkok 10140, Thailand.

Uric acid (UA) and creatinine are the imperative biological substance for clinical monitoring and diagnosis. Measuring the ratio between uric acid and creatinine in urine helps differentiate acute uric acid nephropathy from the hyperuricemia that secondarily occurs to renal failure. In general, the ratio is greater than 0. Read More

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http://dx.doi.org/10.1155/2019/3457247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377961PMC
February 2019
2 Reads

Renal Disorders in Pulmonary Sarcoidosis Patients.

Iran J Kidney Dis 2019 Jan;13(1):21-26

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Introduction: The frequency of kidney disorders varies in pulmonary sarcoidosis patients. Since the prevalence of kidney disorders among Iranian sarcoidosis patients is uncertain, this study aimed to evaluate kidney disorders and associated manifestations in Iranian pulmonary sarcoidosis patients.

Materials And Methods: One hundred patients with confirmed granuloma as pulmonary sarcoidosis were studied for renal disorders. Read More

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January 2019
4 Reads
0.979 Impact Factor

Hesperetin ameliorates diabetic nephropathy in rats by activating Nrf2/ARE/glyoxalase 1 pathway.

Biomed Pharmacother 2019 Mar 12;111:1166-1175. Epub 2019 Jan 12.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China; Department of Pharmacology, School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, Jiangsu, China. Electronic address:

Diabetic nephropathy (DN) is one of the most common diabetic complications, and alpha-carbonyl aldehydes and their detoxicating enzyme glyoxalase 1 (Glo-1) play vital roles in pathogenesis of diabetic complications. The aim of this study was to evaluate the renoprotective effects of hesperetin against DN in rats, and to investigate mechanisms from the aspect of Nrf2/ARE/Glo-1 pathway. Streptozotocin-induced diabetic rats were treated orally with hesperetin (50 and 150 mg/kg), or nuclear factor erythroid-derived-2-like 2 (Nrf2) inducer tert-butylhydroquinone (tBHQ, 25 mg/kg) for 10 weeks. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183824
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http://dx.doi.org/10.1016/j.biopha.2019.01.030DOI Listing
March 2019
6 Reads

Fu Brick Tea Alleviates Chronic Kidney Disease of Rats with High Fat Diet Consumption through Attenuating Insulin Resistance in Skeletal Muscle.

J Agric Food Chem 2019 Mar 4;67(10):2839-2847. Epub 2019 Mar 4.

Shaanxi Engineering Laboratory for Food Green Processing and Safety Control, and Shaanxi Key Laboratory for Hazard Factors Assessment in Processing and Storage of Agricultural Products, College of Food Engineering and Nutritional Science , Shaanxi Normal University , Xi'an 710119 , China.

Fu brick tea is a unique post-fermented dark tea product which undergoes controlled fermentation by "golden flower" fungus Eurotium cristatum. This study examined the effects of Fu brick tea aqueous extract (FTE) to alleviate insulin resistance, chronic kidney disease (CKD), and its regulatory mechanism in high fat diet (HFD)-induced obese rats. Sixteen-week administration of FTE at 400 mg/kg bw in rats significantly antagonized HFD-induced insulin resistance and CKD with elevations in serum leptin, TC, TG, LDL-C, blood urea nitrogen, uric acid, and creatinine levels, respectively ( p < 0. Read More

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http://dx.doi.org/10.1021/acs.jafc.8b06927DOI Listing
March 2019
3 Reads

Relationship between serum uric acid and clustering of cardiovascular disease risk factors and renal disorders among Shanghai population: a multicentre and cross-sectional study.

BMJ Open 2019 Mar 1;9(3):e025453. Epub 2019 Mar 1.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Objectives: To estimate the current prevalence of cardiovascular disease risk factors (CRFs) and renal disorders across serum uric acid (SUA) quartiles, and evaluate the relationships between SUA and CRFs and renal diseases in Shanghai population.

Study Design: Observational, cross-sectional study.

Setting: Data were obtained from the physical check-up of local residents at three hospitals in Shanghai. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025453DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429858PMC
March 2019
5 Reads

Effects of Serum Cytochrome c on Contrast-Induced Nephropathy in Patients with ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.

Biomed Res Int 2019 23;2019:9357203. Epub 2019 Jan 23.

Department of Cardiology, Zhongda Hospital of Southeast University Medical School, Nanjing 210009, China.

Background And Aims: Contrast-induced nephropathy (CIN) is a relatively infrequent complication after percutaneous coronary intervention (PCI) in patients with ST-elevation myocardial infarction (STEMI). However, little is known about the association between cytochrome c (cyt c) and increased risk of CIN. We conducted this study to explore the impact of serum cyt c on the occurrence of CIN. Read More

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http://dx.doi.org/10.1155/2019/9357203DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364113PMC
January 2019

A Fast Decline of Residual Renal Function in the First Year is a Predictor for Early Withdrawal from Peritoneal Dialysis in Non-Diabetic Patients.

Kidney Blood Press Res 2019 22;44(1):12-21. Epub 2019 Feb 22.

Kidney Disease Center, The First Affiliated Hospital, Medical School of Zhejiang University, Hangzhou, China,

Background/aims: Little is known about the relationship between residual renal function (RRF) decline in early period and survival in non-diabetic peritoneal dialysis (PD) patients.

Methods: A total of 567 non-diabetic patients who began PD from January 1, 2005 to June 30, 2013 was investigated. The rate of RRF decline was determined by the "slope of the trend equation" of serial RRFs. Read More

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http://dx.doi.org/10.1159/000497807DOI Listing

Plasma metabolites and lipids associate with kidney function and kidney volume in hypertensive ADPKD patients early in the disease course.

BMC Nephrol 2019 Feb 25;20(1):66. Epub 2019 Feb 25.

Division of Nephrology, Department of Internal Medicine, University of California, Genome and Biomedical Sciences Building, Room 6311, 451 Health Sciences Dr, Davis, CA, 95616, USA.

Background: Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and is characterized by gradual cyst growth and expansion, increase in kidney volume with an ultimate decline in kidney function leading to end stage renal disease (ESRD). Given the decades long period of stable kidney function while cyst growth occurs, it is important to identify those patients who will progress to ESRD. Recent data from our and other laboratories have demonstrated that metabolic reprogramming may play a key role in cystic epithelial proliferation resulting in cyst growth in ADPKD. Read More

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http://dx.doi.org/10.1186/s12882-019-1249-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388487PMC
February 2019
2 Reads

Effects of the SGLT-2 Inhibitor Canagliflozin on Adenine-Induced Chronic Kidney Disease in Rats.

Cell Physiol Biochem 2019 18;52(1):27-39. Epub 2019 Feb 18.

Department of Physiology, College of Medicine and Health Sciences, UAE University, Al Ain, United Arab Emirates.

Background/aims: SGLT-2 inhibitors have been shown to be nephroprotective in diabetes. Here, we examined if one of these drugs (canagliflozin) could also ameliorate non-diabetic chronic kidney disease (CKD).

Methods: CKD was induced in rats by feeding them adenine (0. Read More

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http://dx.doi.org/10.33594/000000003DOI Listing
March 2019
2 Reads
2.875 Impact Factor

Insulin resistance and chronic kidney disease progression, cardiovascular events, and death: findings from the chronic renal insufficiency cohort study.

BMC Nephrol 2019 Feb 20;20(1):60. Epub 2019 Feb 20.

Division of Renal-Electrolyte and Hypertension, Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, 19103, PA, USA.

Background: Insulin resistance contributes to the metabolic syndrome, which is associated with the development of kidney disease. However, it is unclear if insulin resistance independently contributes to an increased risk of chronic kidney disease (CKD) progression or CKD complications. Additionally, predisposing factors responsible for insulin resistance in the absence of diabetes in CKD are not well described. Read More

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http://dx.doi.org/10.1186/s12882-019-1220-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383235PMC
February 2019
3 Reads

Molecular alterations induced by fructose and its impact on metabolic diseases

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):491-504. Epub 2019 Jan 28.

Instituto Mexicano del Seguro Social, Hospital de Especialidades “Dr. Bernardo Sepúlveda Gutiérrez”, Unidad de Investigación Médica en Bioquímica. Ciudad de México, México

Scientific evidence has identified that the excessive consumption of products made from high-fructose corn syrup is a trigger for obesity, whose prevalence increased in recent years. Due to the metabolic characteristics of fructose, a rapid gastric emptying is produced, altering signals of hunger-satiety and decreasing the appetite. In addition to the hepatic level during catabolism, triose phosphate is generated and adenosine triphosphate (ATP) is reduced, producing uric acid. Read More

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January 2019
1 Read

Pharmacological urate-lowering approaches in chronic kidney disease.

Eur J Med Chem 2019 Mar 23;166:186-196. Epub 2019 Jan 23.

Kidney Research Laboratory, Division of Nephrology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, 610041, China. Electronic address:

Chronic kidney disease (CKD) has become a global public health issue and uric acid (UA) remains a major risk factor of CKD. As the main organ for the elimination of UA, kidney owned a group of urate transporters in tubular epithelium. Kidney disease hampered the UA excretion, and the accumulation of serum UA in return harmed the renal function. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.01.043DOI Listing
March 2019
1 Read

Analysis of chronic kidney disease staging with different estimated glomerular filtration rate equations in Chinese centenarians.

Chin Med J (Engl) 2019 Mar;132(5):512-518

Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Beijing 100853, China.

Background: Accurate estimation of the glomerular filtration rate (GFR) and staging of chronic kidney disease (CKD) are important. Currently, there is no research on the differences in several estimated GFR equations for staging CKD in a large sample of centenarians. Thus, this study aimed to investigate the differences in CKD staging with the most commonly used equations and to analyze sources of discrepancy. Read More

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http://Insights.ovid.com/crossref?an=00029330-900000000-9994
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http://dx.doi.org/10.1097/CM9.0000000000000079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416091PMC
March 2019
7 Reads

Uric acid induced epithelial-mesenchymal transition of renal tubular cells through PI3K/p-Akt signaling pathway.

J Cell Physiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Nephrology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.

The phenotypic changes of tubular epithelial cell are hallmark features of renal diseases caused by abnormal uric acid levels. We hereby intend to investigate whether PI3K/p-Akt signaling plays a role in uric-acid induced epithelial-mesenchymal transition process. The normal rat kidney cell line (NRK-52E) was used as a proximal tubular cell model in this study. Read More

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http://doi.wiley.com/10.1002/jcp.28203
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http://dx.doi.org/10.1002/jcp.28203DOI Listing
February 2019
8 Reads

Beneficial effects of SGLT2 inhibitors on fatty liver in type 2 diabetes: A common comorbidity associated with severe complications.

Authors:
A J Scheen

Diabetes Metab 2019 Jan 29. Epub 2019 Jan 29.

Division of Clinical Pharmacology, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, and Division of Diabetes, Nutrition and Metabolic Disorders, Department of Medicine, CHU Liège, Liège, Belgium. Electronic address:

Patients with type 2 diabetes mellitus (T2DM) are exposed to non-alcoholic fatty liver disease (NAFLD), a comorbidity associated with cardiovascular disease and chronic kidney disease, and which may progress to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis. Sodium-glucose cotransporter type-2 (SGLT2) inhibitors are glucose-lowering agents that improve glucose control while promoting weight loss and lowering serum uric acid levels. These agents may exert cardiovascular and renal protection in T2DM patients with established cardiovascular disease. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.01.008DOI Listing
January 2019
3 Reads

Allopurinol and loss of consciousness in a 78-old year man suffering from gout.

Infect Disord Drug Targets 2019 Jan 27. Epub 2019 Jan 27.

Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad. Iran.

Allopurinol is an FDA-Approved xanthine oxidase inhibitor that uses in the treatment of gout, hyperuricemia and uremic kidney stones in the patients with an increased level of uric acid excretion. Xanthine oxidase acts by converting hypoxanthine and xanthine to uric acid, and therefore its inhibition will result in decreased production of uric acid. The most common side effects of this medication are as follows: maculopapular rashes, hives, itching, headache, dizziness, abnormal hair loss, fever and hypersensitivity reaction. Read More

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http://dx.doi.org/10.2174/1871526519666190128102039DOI Listing
January 2019
5 Reads

[Risk factors for deterioration of liver functions after successful kidney transplantation].

Orv Hetil 2019 Feb;160(5):186-190

Sebészeti Klinika, Szegedi Tudományegyetem, Általános Orvostudományi Kar Szeged, Semmelweis u. 8., 6721.

Introduction: Increase of liver function is one of the most common complications after kidney transplantation due to the use of immunosuppressive therapy and hyperlipidemia in addition to hepatitis C virus (HCV) infection.

Method: Following the selection criteria (n = 59), the study is based on applied immunosuppressive therapy, baseline data of patients, further correlation between HCV and liver function deterioration. Patients were subjected to fasting laboratory examination to monitor serum electrolytes, uric acid and albumin levels. Read More

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https://www.akademiai.com/doi/10.1556/650.2019.31257
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http://dx.doi.org/10.1556/650.2019.31257DOI Listing
February 2019
8 Reads

Correlations between related-purine derivatives and renal disorders in patients with psoriasis vulgaris.

Exp Ther Med 2019 Feb 5;17(2):1012-1019. Epub 2018 Dec 5.

Department of Dermatology, 'Victor Babes' Clinical Hospital for Infectious Diseases, 030303 Bucharest, Romania.

Recent data suggest that severe psoriasis is an independent risk factor for chronic renal disease. In the present study, we investigated the role of related-purine derivatives as predictors of renal dysfunctions in patients with psoriasis. A prospective study was conducted on a group of 45 patients with psoriasis vulgaris and 45 control cases, monitored over a 5-year period. Read More

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http://dx.doi.org/10.3892/etm.2018.7053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6327447PMC
February 2019
8 Reads

Daily Green Tea Infusions in Hypercalciuric Renal Stone Patients: No Evidence for Increased Stone Risk Factors or Oxalate-Dependent Stones.

Nutrients 2019 Jan 24;11(2). Epub 2019 Jan 24.

Sorbonne Université, Service d'Explorations Fonctionnelles Multidisciplinaires, AP-HP, Hôpital Tenon, 75020 Paris, France.

Green tea is widely used as a ''healthy'' beverage due to its high level of antioxidant polyphenol compounds. However tea is also known to contain significant amount of oxalate. The objective was to determine, in a cross-sectional observational study among a population of 273 hypercalciuric stone-formers referred to our center for metabolic evaluation, whether daily green tea drinkers ( = 41) experienced increased stone risk factors (especially for oxalate) compared to non-drinkers. Read More

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http://dx.doi.org/10.3390/nu11020256DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6412450PMC
January 2019
3 Reads

Novel therapies for diabetic kidney disease.

Kidney Int Suppl (2011) 2018 Jan 29;8(1):18-25. Epub 2017 Dec 29.

Department of Medicine, American Society of Hypertension Comprehensive Hypertension Center, University of Chicago Medicine, Chicago, Illinois, USA.

Over the past 30 years there have been many complementary therapies developed to achieve glycemic control and have an impact on cardiovascular outcomes, as well as reduce the risk of microvascular disease. The 2 most notable new entries have been the sodium-glucose cotransporter 2 (SGLT2) inhibitors and the glucagon-like peptide-1 (GLP-1) agonists. Both these classes of agents have demonstrated reductions in cardiovascular event rates as well as reductions in blood pressure and weight. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S21571716173006
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http://dx.doi.org/10.1016/j.kisu.2017.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6336219PMC
January 2018
12 Reads

Long non-coding RNA ANRIL-mediated inflammation response is involved in protective effect of rhein in uric acid nephropathy rats.

Cell Biosci 2019 17;9:11. Epub 2019 Jan 17.

1Department of Traditional Chinese Medicine, Renmin Hospital of Wuhan University, No. 99 Zhangzhidong Road, Wuhan, 430060 China.

Background: The aim of this study was to investigate the role of long non-coding RNAs (LncRNAs) antisense non-coding RNA in the INK4 locus (ANRIL) in anti-inflammation of rhein in uric acid nephropathy (UAN) rats.

Methods: Rat models of UAN were induced by adenine and potassium oxonate. Enzyme-linked immunosorbent assay (ELISA) was performed to assess inflammation factor in serum and supernatant. Read More

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http://dx.doi.org/10.1186/s13578-019-0273-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335822PMC
January 2019
3 Reads

The ameliorative effect of quercetin on bisphenol A-induced toxicity in mitochondria isolated from rats.

Environ Sci Pollut Res Int 2019 Mar 21;26(8):7688-7696. Epub 2019 Jan 21.

Department of Pharmacology and Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Recent studies have demonstrated that bisphenol A (BPA) has an adverse or toxic effect on the kidney. This study was designed to evaluate the ability of quercetin (QUER) to prevent BPA-induced mitochondrial dysfunction. Thirty-two healthy adult male Wistar rats were randomly divided into four groups, as follows: control group (olive oil), BPA group (250 mg/kg), BPA þ QUER group (250 mg/kg + 75 mg/kg), and QUER group (75 mg/kg). Read More

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http://dx.doi.org/10.1007/s11356-018-04119-5DOI Listing
March 2019
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Blockade of ERK1/2 by U0126 alleviates uric acid-induced EMT and tubular cell injury in rats with hyperuricemic nephropathy.

Am J Physiol Renal Physiol 2019 Apr 16;316(4):F660-F673. Epub 2019 Jan 16.

Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine , Shanghai , China.

Extracellular signal-regulated kinases 1 and 2 (ERK1/2) are serine/threonine kinases and function as regulators of cellular proliferation and differentiation. Recently, we demonstrated that inhibition of ERK1/2 alleviates the development and progression of hyperuricemia nephropathy (HN). However, its potential roles in uric acid-induced tubular epithelial-mesenchymal transition (EMT) and tubular epithelial cell injury are unknown. Read More

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http://dx.doi.org/10.1152/ajprenal.00480.2018DOI Listing
April 2019
6 Reads

Hyperuricemia is associated with acute kidney injury and all-cause mortality in hospitalized patients.

Nephrology (Carlton) 2019 Jan 15. Epub 2019 Jan 15.

Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Background: Hyperuricemia is a risk factor for high morbidity and mortality in several diseases. However, the relationship between uric acid and the risk of acute kidney injury (AKI) and mortality remains unresolved in hospitalized patients.

Methods: Data from 18,444 hospitalized patients were retrospectively reviewed. Read More

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http://dx.doi.org/10.1111/nep.13559DOI Listing
January 2019
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ShenShuai II Recipe Attenuates Apoptosis and Renal Fibrosis in Chronic Kidney Disease by Increasing Renal Blood Flow and Improving Oxygen Consumption.

Evid Based Complement Alternat Med 2018 13;2018:7602962. Epub 2018 Dec 13.

Department of Nephrology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

. Hypoxia plays a significant role in the progression of chronic kidney disease (CKD) and renal fibrosis. In China, Chinese herbal medicine has been widely used to treat CKD. Read More

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http://dx.doi.org/10.1155/2018/7602962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311238PMC
December 2018
5 Reads
1.880 Impact Factor

The clinical and pathological features of adefovir dipivoxil-related renal impairment
.

Clin Nephrol 2019 Mar;91(3):180-186

Aims: To investigate the clinicopathological features and outcomes of adefovir dipivoxil (ADV)-related renal impairment in Chinese patients.

Materials And Methods: Clinical, pathological, and follow-up data from 15 patients with ADV-related renal impairment were studied. Proximal renal tubular dysfunction (PRTD) was defined by the presence of at least two of the following four abnormalities: hypophosphatemia, hypouricemia, nondiabetic glucosuria, and proteinuria. Read More

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http://dx.doi.org/10.5414/CN109574DOI Listing
March 2019
5 Reads
1.232 Impact Factor

Rasburicase induced severe hemolysis and methemoglobinemia in a Caucasian patient complicated by acute renal failure and ARDS.

Respir Med Case Rep 2019 23;26:142-145. Epub 2018 Dec 23.

Pulmonary and Critical Care Medicine, Marshall University School of Medicine, Huntington, WV, USA.

Rasburicase is a recombinant urate-oxidase enzyme and is a very important medication for tumor lysis syndrome. Methemoglobinemia and hemolysis are known side effects of rasburicase that result from oxidative stress caused by hydrogen peroxide, a byproduct generated during the breakdown of uric acid to allantoin. Patients with G6PD deficiency have a decreased tolerance to oxidative stress and are therefore at a greater risk of hemolysis and methemoglobinemia with rasburicase. Read More

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http://dx.doi.org/10.1016/j.rmcr.2018.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307101PMC
December 2018
2 Reads

Uric acid and contrast-induced nephropathy: an updated review and meta-regression analysis.

Postepy Kardiol Interwencyjnej 2018 11;14(4):399-412. Epub 2018 Dec 11.

Department of Cardiovascular Sciences, Sapienza University, Rome, Italy.

Introduction: Previous studies have suggested a relationship between serum uric acid and contrast-induced nephropathy (CIN).

Aim: We performed an updated review and a meta-regression analysis to assess whether serum uric acid is associated with CIN or there exists any relationship between serum uric acid and other risk factors for CIN.

Material And Methods: We searched PubMed, Embase and Cochrane databases and reviewed cited references up to July 31, 2018 to identify relevant studies. Read More

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https://www.termedia.pl/doi/10.5114/aic.2018.79870
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http://dx.doi.org/10.5114/aic.2018.79870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309842PMC
December 2018
4 Reads

Mild cognitive impairment in maintenance hemodialysis patients: a cross-sectional survey and cohort study.

Clin Interv Aging 2019 20;14:27-32. Epub 2018 Dec 20.

Department of Geriatric Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China,

Introduction: Few studies focused on mild cognitive impairment (MCI) in maintenance hemodialysis (MHD) patients. This study was conducted to survey the prevalence, the potent risk factors of MCI in MHD patients, and further observe the progress of MCI in a period of 6 months.

Methodology: Mini-Mental State Examination, and Montreal Cognitive Assessment were used to assess cognitive condition. Read More

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https://www.dovepress.com/mild-cognitive-impairment-in-maint
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http://dx.doi.org/10.2147/CIA.S178854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304252PMC
February 2019
15 Reads

Baseline Serum Cystatin C Is a Potential Predictor for Acute Kidney Injury in Patients with Acute Pancreatitis.

Dis Markers 2018 19;2018:8431219. Epub 2018 Nov 19.

Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, 241001 Anhui, China.

Aims: The study is aimed at studying the incidence of acute kidney injury (AKI) and exploring the potential predictor for AKI in patients with acute pancreatitis.

Methods: A retrospective study adopting a stratified cohort sampling design was performed in a cohort of patients ( = 237) diagnosed with acute pancreatitis without any renal injury. The following information including age, gender, serum creatinine, serum urea nitrogen, serum uric acid, serum cystatin C, fasting serum glucose, serum amylase, serum lipase, serum choline esterase, total protein, albumin, globulin, total bilirubin, direct bilirubin, total bile acids, glutamic-pyruvic transaminase, glutamic-oxaloacetic transaminase, gamma glutamyl transpeptidase, and alkaline phosphatase were collected from each patient when they were diagnosed with acute pancreatitis. Read More

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http://dx.doi.org/10.1155/2018/8431219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276423PMC
April 2019
4 Reads

The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion.

Biomed Pharmacother 2019 Mar 20;111:162-168. Epub 2018 Dec 20.

College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China. Electronic address:

Uric acid metabolic disorder is considered to be the main pathogenesis of uric acid nephropathy (UN). Smilax glabra Roxb. is a traditional Chinese herb which has been used in the treatment of gout, but the mechanism was unclear. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.12.050DOI Listing
March 2019
5 Reads

A Case Report of Immunosuppressant Medication‒Associated Polyarticular Tophaceous Gout Successfully Treated Using the Polyethylene Glycol‒Conjugated Uricase Enzyme Pegloticase.

Authors:
B Freyne

Transplant Proc 2018 Dec 9;50(10):4099-4101. Epub 2018 Mar 9.

Private practice, Murrieta, California. Electronic address:

This case describes a female patient with polyarticular tophaceous gout who was given transplant immunosuppressant medications. The 36-year-old was treated for Wilms tumor at 3 years of age by operative removal of 1 kidney, chemotherapy, and radiotherapy. At age 19, the patient was diagnosed with cardiomyopathy attributed to prior chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.03.010DOI Listing
December 2018
2 Reads

Being Overweight Is Related to Faster Decline in Annual Glomerular Filtration Rate in Kidney Transplant.

Transplant Proc 2018 Dec 18;50(10):3392-3396. Epub 2018 Apr 18.

Centro de Nefrología, Hospital de Clínicas, Facultad de Medicina, UdeLaR, Montevideo, Uruguay.

Few studies have examined the relationship between non-immunological factors and glomerular filtration rate (GFR) decline in kidney transplant. Correcting these factors in native kidneys slows the progression of chronic kidney disease. The aim of this study was to analyze the association between the control of non-immunological factors and the annual decline of GFR. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.04.040DOI Listing
December 2018
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Conversion From Mycophenolates to Mizoribine Is Associated With Lower BK Virus Load in Kidney Transplant Recipients: A Prospective Study.

Transplant Proc 2018 Dec;50(10):3356-3360

Organ Transplant Center, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: BK virus allograft nephropathy (BKVAN) is a graft-threatening complication after kidney transplantation. Current consensus regarding the prevention of BKVAN is to screen for BK viremia and to treat sustained BK viremia through reducing immunosuppression. This study assessed the effect of conversion from mycophenolates to mizoribine (MZR) on the prevention of BK viremia in kidney transplant recipients. Read More

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http://dx.doi.org/10.1016/j.transproceed.2018.01.059DOI Listing
December 2018
5 Reads

Risk Factors and Mechanisms Underlying Cross-Shift Decline in Kidney Function in Guatemalan Sugarcane Workers.

J Occup Environ Med 2019 Mar;61(3):239-250

Center for Health, Work & Environment (Dr Sorensen, Dr Butler-Dawson, Ms Dally, Ms Krisher, Ms Tenney, Dr Newman); Department of Emergency Medicine, University of Colorado School of Medicine (Dr Sorensen, Dr Lemery); Colorado Consortium on Climate Change and Human Health (Dr Sorensen, Dr Butler-Dawson, Ms Dally, Ms Krisher, Dr Johnson, Dr Lemery, Ms Tenney, Dr Newman); Department of Environmental and Occupational Health (Dr Butler-Dawson, Ms Dally, Ms Krisher, Ms Tenney, Dr Newman), Colorado School of Public Health; Division of Renal Diseases and Hypertension (Dr Griffin, Dr Johnson); Pantaleon, Guatemala (Mr Asensio); Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, School of Medicine (Dr Newman), University of Colorado, Aurora, Colorado.

Objective: Identify early biomarkers and mechanisms of acute kidney injury in workers at risk of developing chronic kidney disease of unknown origin (CKDu).

Methods: We assessed cross-shift changes in kidney function and biomarkers of injury in 105 healthy sugarcane workers. We obtained pre-harvest clinical data as well as daily environmental, clinical, and productivity data for each worker. Read More

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http://dx.doi.org/10.1097/JOM.0000000000001529DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416034PMC
March 2019
3 Reads