6,204 results match your criteria Urethral Cancer


A novel method for near-infrared fluorescence imaging of the urethra during perineal and transanal surgery: demonstration in a cadaveric model.

Colorectal Dis 2020 May 22. Epub 2020 May 22.

Institute of Physiology, EA3072 Mitochondria Respiration and Oxidative Stress, University of Strasbourg, Strasbourg, France.

Aim: TaTME is a promising novel sphincter-saving procedure for low rectal cancer. However, the transanal bottom-up dissection is associated with increased rates of iatrogenic urethral injuries. Near-infrared fluorescence (NIRF) imaging, given its deeper tissue penetration, has been explored in a limited number of studies for enhanced intraoperative urethral visualization. Read More

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http://dx.doi.org/10.1111/codi.15156DOI Listing

Clear cell carcinoma in a urethral diverticulum.

Urol Case Rep 2020 Sep 3;32:101164. Epub 2020 Apr 3.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

A 54-year-old female presented with a long history of multi-drug-resistant urinary tract infections, urinary urgency and frequency, haematuria, stress urinary incontinence and difficulty voiding. Examination revealed a large, hard anterior vaginal wall mass with purulent discharge. Investigation with MRI demonstrated a complex urethral diverticulum containing stones with fistulation into the vagina. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229268PMC
September 2020

Human papillomavirus 16-positive penile Bowen's disease involving the distal urethra: A case report.

SAGE Open Med Case Rep 2020 13;8:2050313X20918985. Epub 2020 May 13.

Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.

A 79-year-old man visited our hospital with a chief complaint of erythema around the urethral orifice of the glans, and a diagnosis of penile Bowen's disease was made by penile skin biopsy. Initially, local tumor resection with skin grafting from the femoral skin was performed. However, histopathological examination revealed a positive urethral margin of tumor. Read More

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http://dx.doi.org/10.1177/2050313X20918985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7223195PMC

Urinary Morbidity in Men Treated With Stereotactic Body Radiation Therapy (SBRT) for Localized Prostate Cancer Following Transurethral Resection of the Prostate (TURP).

Front Oncol 2020 5;10:555. Epub 2020 May 5.

Department of Radiation Medicine, Georgetown University Hospital, Washington, DC, United States.

Clinical data suggest that stereotactic body radiation therapy (SBRT) provides similar clinical outcomes as other radiation modalities for prostate cancer. However, data reporting on the safety of SBRT after TURP is limited. Herein, we report our experience using SBRT to deliver hypofractionated radiotherapy in patients with a history of TURP including physician-reported toxicities and patient-reported quality of life. Read More

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http://dx.doi.org/10.3389/fonc.2020.00555DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214538PMC

Computer-assisted real-time automatic prostate segmentation during TaTME: a single-center feasibility study.

Surg Endosc 2020 May 19. Epub 2020 May 19.

Surgical Device Innovation Office, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, 277-8577, Japan.

Background: Urethral injuries (UIs) are significant complications pertaining to transanal total mesorectal excision (TaTME). It is important for surgeons to identify the prostate during TaTME to prevent UI occurrence; intraoperative image navigation could be considered useful in this regard. This study aims at developing a deep learning model for real-time automatic prostate segmentation based on intraoperative video during TaTME. Read More

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http://dx.doi.org/10.1007/s00464-020-07659-5DOI Listing

Avoiding urethral and rectal injury during transperineal abdominoperineal resection in male patients with anorectal cancer.

Surg Endosc 2020 May 19. Epub 2020 May 19.

Department of Gastroenterological Surgery, Faculty of Medicine, Fukuoka University, Fukuoka, Japan.

Background: In abdominoperineal resection (APR) in male patients with rectal cancer, high margin involvement and urethral injury have been reported to result from difficulty in dissecting the anterior anorectum. Recently, the efficacy of an endoscopic down-to-up rectal dissection was reported. Here, we present a safe and simple technique for anterior dissection using a simultaneous laparoscopic and transperineal endoscopic approach. Read More

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http://dx.doi.org/10.1007/s00464-020-07655-9DOI Listing

Association of preoperative urethral parameters on magnetic resonance imaging and immediate recovery of continence following Retzius-sparing robot-assisted radical prostatectomy.

Transl Androl Urol 2020 Apr;9(2):501-509

Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China.

Background: Studies regarding predictive factors of urinary continence following Retzius-sparing radical prostatectomy (RP) is limited. This study was designed to evaluate association of urethral parameters on preoperative magnetic resonance imaging (MRI) and immediate recovery of urinary continence following Retzius-sparing robot assisted radical prostatectomy (RS-RARP).

Methods: This retrospective cohort study enrolled 156 patients with clinically localized prostate cancer who underwent MRI before RS-RARP. Read More

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http://dx.doi.org/10.21037/tau.2019.12.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7215013PMC

Spatial distribution of smooth muscle tissue in the female pelvic floor and surrounding the urethra and vagina.

Anat Sci Int 2020 May 17. Epub 2020 May 17.

Department of Clinical Anatomy, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8510, Japan.

Data regarding urethral supporting structures are insufficient for understanding the mechanism of stress urinary incontinence. Whether smooth muscle fibers contribute to urethral support and pelvic floor support structures is unclear. This study aimed to clarify the histological structures and spatial distributions of smooth muscle tissues surrounding the urethra and vagina. Read More

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http://dx.doi.org/10.1007/s12565-020-00549-9DOI Listing

Transvesical Robot Assisted Radical Prostatectomy: Initial Experience and Surgical Outcomes.

BJU Int 2020 May 13. Epub 2020 May 13.

Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objectives: To describe the detailed techniques for transvesical robot-assisted radical prostatectomy (TvRARP) using da Vinci Si/Xi system and evaluate the functional and oncological outcomes in 35 prostate cancer patients.

Patients And Methods: 35 patients with localized prostate cancer were enrolled for TvRARP. Preoperative data of patients [mean ± SD: patient age 63. Read More

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http://dx.doi.org/10.1111/bju.15111DOI Listing

Linac-based SBRT as a feasible salvage option for local recurrences in previously irradiated prostate cancer.

Strahlenther Onkol 2020 May 12. Epub 2020 May 12.

Advanced Radiation Oncology Department, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.

Background And Objective: The optimal management of prostate cancer (PC) recurrences after definitive or postoperative radiotherapy (RT) is still controversial. The aim of the present retrospective study was to report the preliminary clinical results and toxicity of a mono-institutional series of patients re-irradiated with linac-based SBRT in recurrent prostate cancer.

Methods: Inclusion criteria were previous definitive or adjuvant/salvage RT, evidence of biochemical recurrence and radiological detection of local relapse (Magnetic Resonance Imaging or PSMA/choline-Positron Emission Tomography), and IPSS <10. Read More

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http://dx.doi.org/10.1007/s00066-020-01628-6DOI Listing

A Prospective Randomized Controlled Trial of Irrigation "Bag Squeeze" to Manage Pain for Patients Undergoing Flexible Cystoscopy.

J Urol 2020 May 12:101097JU0000000000001139. Epub 2020 May 12.

Division of Urology, Department of Surgical Oncology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

Purpose: Determine if "bag-squeeze" technique decreases pain during flexible cystoscopy in men.

Methods And Materials: A single center, prospective, double-blinded randomized controlled trial recruiting 200 consenting participants who were ambulatory, outpatient males who had undergone a prior cystoscopy and were not expected to require any secondary procedures. Men with prior urethral stricture or bladder neck contracture were excluded. Read More

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http://dx.doi.org/10.1097/JU.0000000000001139DOI Listing
May 2020
4.471 Impact Factor

Does intraoperative frozen section really predict significant positive surgical margins after robot-assisted laparoscopic prostatectomy? A retrospective study.

Asian J Androl 2020 May 1. Epub 2020 May 1.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul 05505, Korea.

We investigated the relationship between positive surgical margin (PSM)-related factors and biochemical recurrence (BCR) and the ability of intraoperative frozen sections to predict significant PSM in patients with prostate cancer. The study included 271 patients who underwent robot-assisted laparoscopic prostatectomy with bilateral nerve sparing and maximal urethral preservation. Intraoperative frozen sections of the periurethra, dorsal vein, and bladder neck were analyzed. Read More

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http://dx.doi.org/10.4103/aja.aja_16_20DOI Listing

Personalized chemotherapy in clear cell adenocarcinoma of the urethra: A case report.

World J Clin Oncol 2020 Apr;11(4):243-249

Norton Cancer Institute, Norton Healthcare, Louisville, KY 40202, United States.

Background: Clear cell adenocarcinoma of the urethra is a rare type of aggressive cancer with a poor prognosis. Clear cell carcinoma of the urethra represents less than 0.02% of all malignancies in women. Read More

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http://dx.doi.org/10.5306/wjco.v11.i4.243DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186237PMC

Use of a lighted stent to avoid urethral injury during robotic intersphincteric resection for secondary rectal cancer following prior radiotherapy to prostate cancer - a video vignette.

Colorectal Dis 2020 Apr 29. Epub 2020 Apr 29.

Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

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http://dx.doi.org/10.1111/codi.15087DOI Listing

Primary Urethral Cancer - Treatment Patterns and Associated Outcomes.

BJU Int 2020 Apr 26. Epub 2020 Apr 26.

Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, United States.

Objectives: To evaluate treatment patterns and associated outcomes of patients with urethral cancer.

Patients And Methods: After obtaining IRB approval we identified 165 patients treated for primary urethral cancer between 1956-2017. Treatment included monotherapy (surgery or radiation), dual-therapy (surgery+radiation, surgery+chemotherapy, or chemotherapy+radiation) or triple-therapy (surgery+radiation+chemotherapy). Read More

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http://dx.doi.org/10.1111/bju.15095DOI Listing

Risk factors and oncological outcomes of urethral recurrence in male patients with muscle invasive bladder cancer after radical cystectomy combined with urinary diversion: a propensity score-matched case control study.

Int J Clin Oncol 2020 Apr 21. Epub 2020 Apr 21.

Department of Urology, Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang, 110004, Liaoning, People's Republic of China.

Background: Radical cystectomy (RC) is the primary treatment strategy for muscle invasive bladder cancer (MIBC). However, it carries a high risk of urethral recurrence (UR) in male patients. The risk factors and oncological outcomes of UR remain unclear. Read More

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http://dx.doi.org/10.1007/s10147-020-01679-wDOI Listing

Major Complications after Male Anti-IncontinenceProcedures: Predisposing Factors, Management and Prevention.

Urol J 2020 Apr 20. Epub 2020 Apr 20.

Department of Urology and Centre of Urooncology, Semmelweis University, Budapest, HUNGARY.

Purpose: Significant post-prostatectomy incontinence (PPI) is a crippling condition and managed best through sling or artificial urinary sphincter (AUS) implantation. These procedures are often associated with complications requiring surgical intervention. The aim of our retrospective study was to evaluate the occurrence of major complications and identify risk factors. Read More

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http://dx.doi.org/10.22037/uj.v0i0.5712DOI Listing

Urine colour as an indicator for anastomotic leakage after robot-assisted radical prostatectomy.

Scand J Urol 2020 Apr 20:1-7. Epub 2020 Apr 20.

Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.

To determine whether macroscopic haematuria predicts urethrovesical anastomotic leakage after robot-assisted laparoscopic radical prostatectomy (RALP) as well as a cystogram. Participants were recruited before cystogram and catheter removal 5-14 days after RALP surgery. Urine colour in the collection bag was classified according to a three-step scale (clear, light red and dark red) and leakages in cystogram were graded with a four-step scale (Grade 0-3). Read More

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http://dx.doi.org/10.1080/21681805.2020.1750474DOI Listing

Quantitative Characterization of the Prostatic Urethra Using MRI: Implications for Lower Urinary Tract Symptoms in Patients with Benign Prostatic Hyperplasia.

Acad Radiol 2020 Apr 16. Epub 2020 Apr 16.

Molecular Imaging Program, National Cancer Institute, 10 Center Drive, Room B3B85, Bethesda 20892, MD. Electronic address:

Introduction: The aim of this study was to perform a quantitative assessment of the prostate anatomy with a focus on the relation of prostatic urethral anatomic variation to urinary symptoms.

Methods: This retrospective study involved patients undergoing magnetic resonance imaging for prostate cancer who were also assessed for lower urinary tract symptoms. Volumetric segmentations were utilized to derive the in vivo prostatic urethral length and urethral trajectory in coronal and sagittal planes using a piece-wise cubic spline function to derive the angle of the urethra within the prostate. Read More

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http://dx.doi.org/10.1016/j.acra.2020.03.017DOI Listing
April 2020
2.077 Impact Factor

Complete puborectalis, puboperinealis muscle and urethral rhabdomyosphincter preservation in laparoscopic radical prostatectomy: Anatomical landmarks to achieve early urinary continence.

Int J Urol 2020 Apr 16. Epub 2020 Apr 16.

Department of Urology, Moises Broggi Hospital, Barcelona, Spain.

Objectives: To describe our surgical technique of "muscle-sparing" laparoscopic radical prostatectomy and to review relevant anatomical landmarks during the procedure.

Methods: This was a prospective non-controlled case series of 120 consecutive patients who underwent laparoscopic radical prostatectomy, always carried out by the same surgeon (OL). The median follow-up period was 33 months. Read More

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http://dx.doi.org/10.1111/iju.14228DOI Listing

MOHS MICROGRAPHIC SURGERY FOR PENILE CARCINOMA WITH URETHRAL INVASION - A MULTIDISCIPLINARY APPROACH.

J Am Acad Dermatol 2020 Apr 11. Epub 2020 Apr 11.

Dermatology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.04.007DOI Listing

Day Temperature Difference and Aggravation of Low Urinary Tract Symptom in Benign Prostate Hypertrophy Patients in Korea: A National Health Insurance Service-National Cohort-based Study.

Urology 2020 Apr 11. Epub 2020 Apr 11.

Department of Urology, Inje University Sanggye Paik Hospital, Seoul, Korea. Electronic address:

Objective: To investigate the symptom deterioration of patients with benign prostatic hyperplasia (BPH) according to the difference in daily temperature.

Patients And Methods: From the National Health Insurance Service database, we collected and analyzed data on patients with BPH in 6 major metropolitan areas in Korea between January 2008 and December 2017. We investigated the rate of emergency room visits as well as the rate of urethral catheter insertion. Read More

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http://dx.doi.org/10.1016/j.urology.2020.03.040DOI Listing

Leptomeningeal Disease as a Rare Complication of Primary Penile Urethral Cancer.

Case Rep Oncol Med 2020 23;2020:6349456. Epub 2020 Mar 23.

Baylor College of Medicine, Houston, TX, USA.

Primary penile urethral cancer is a rare genitourinary malignancy arising from the epithelial lining of the urethra. Our patient is a 63-year-old male with newly diagnosed penile urethral carcinoma who presented with headache and was found to have leptomeningeal disease on imaging and cerebral spinal fluid analysis. He was treated with systemic and intrathecal chemotherapy with some response and improvement in symptoms. Read More

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http://dx.doi.org/10.1155/2020/6349456DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128049PMC

Evaluation of the urethral α/β ratio and tissue repair half-time for iodine-125 prostate brachytherapy with or without supplemental external beam radiotherapy.

Brachytherapy 2020 May - Jun;19(3):290-297. Epub 2020 Apr 2.

Department of Radiology, Sapporo Medical University, Sapporo, Hokkaido, Japan. Electronic address:

Purpose: To assess the correlation between postimplant dosimetric quantifiers and the genitourinary (GU) toxicity of low-dose rate brachytherapy for prostate cancer.

Methods And Materials: The minimum urethral dose (UD10, 30, and 90) and the percent volume of the urethra receiving the prescription dose (V100, V150) were calculated from the postimplant dose-volume histograms of 182 patients. We then calculated various urethral biologically equivalent doses (uBEDs) using different values of the α/β ratio and tissue repair half-time (t1/2) and examined the correlations with GU toxicity. Read More

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http://dx.doi.org/10.1016/j.brachy.2020.02.007DOI Listing

Gasless robotic perineal radical prostatectomy: Experience of the first 12 cases.

Arch Esp Urol 2020 Apr;73(3):236-241

Department of Urology. University of Health Sciences. Bakirkoy Dr. Sadi Konuk Training and Research Hospital. Istanbul. Turkey.

Objective: To present our results of first 12 patients on whom we performed gasless robotic perineal radical prostatectomy (r-PRP).

Methods: We performed gasless r-PRP on 12 patients between August 2018 and October 2018. Multiparametric magnetic resonance imaging was performed forall patients to exclude local advanced disease. Read More

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Vesico-urethral anastomotic stenosis following radical prostatectomy: a multi-institutional outcome analysis with a focus on endoscopic approach, surgical sequence, and the impact of radiation therapy.

World J Urol 2020 Mar 31. Epub 2020 Mar 31.

University Medical Centre Mannheim, Heidelberg University, Mannheim, Germany.

Objectives: To investigate the predictors of recurrence and of de novo incontinence in patients treated by transurethral incision or resection for vesico-urethral anastomotic stenosis (VUAS) after radical prostatectomy.

Material And Methods: All patients undergoing endoscopic treatment for VUAS between March 2009 and October 2016 were identified in our multi-institutional database. Digital chart reviews were performed and patients contacted for follow-up. Read More

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http://dx.doi.org/10.1007/s00345-020-03157-4DOI Listing

Ureteral and urethral recurrence after radical cystectomy: a systematic review.

Curr Opin Urol 2020 May;30(3):441-448

Department of Urology, Vienna General Hospital, Medical University of Vienna, Vienna, Austria.

Purpose Of Review: The clinical significance of ureteral and urethral recurrence in patients treated with radical cystectomy for bladder cancer is scarce and heterogeneous. The aim of the current review is to summarize the recent literature on incidence, diagnosis and oncologic outcomes of ureteral and urethral recurrences after radical cystectomy.

Recent Findings: Frozen section analysis (FSA) of ureteral margin had a sensitivity and specificity of 69-77 and 83-96%, respectively. Read More

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http://dx.doi.org/10.1097/MOU.0000000000000752DOI Listing

The effect of atropine in preventing catheter-related pain and discomfort in patients undergoing transurethral resection due to bladder tumor; prospective randomized, controlled study.

Korean J Pain 2020 Apr;33(2):176-182

Department of Biostatistics, Hitit University Faculty of Medicine, Çorum, Turkey.

Background: Catheter-related bladder discomfort (CRBD) has been observed in many patients undergoing a urethral catheterization. CRBD may be so severe that the patients require additional analgesics. Muscarinic receptors are involved in the mechanism of CRBD. Read More

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http://dx.doi.org/10.3344/kjp.2020.33.2.176DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7136298PMC

PSMA-PET/CT-avid metastatic prostate cancer to the penis.

BMJ Case Rep 2020 Mar 24;13(3). Epub 2020 Mar 24.

Urology, Princess Alexandra Hospital Health Service District, Woolloongabba, Queensland, Australia.

Penile metastases from prostate cancer (PC) are rarely reported in the literature. Most commonly diagnosed due to presentation with malignant priapism and other urinary symptoms or from findings on clinical examination, prognosis has been reported to be poor. The authors outline a case of penile metastasis from advanced PC. Read More

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http://dx.doi.org/10.1136/bcr-2019-233522DOI Listing

Effect of Reconstructive Techniques on Continence in Robot-Assisted Laparoscopic Prostatectomy: Novel Combination of Long Urethral Stump and Anterior Suspension Suture.

Eurasian J Med 2020 Feb;52(1):57-60

Deparment of Urology, Atatürk University School of Medicine, Erzurum, Turkey.

Objective: To investigate the effects of the novel combination of a long urethral stump and anterior suspension suture in patients who underwent Robot-Assisted Laparoscopic Prostatectomy (RALP) for localized prostate cancer.

Materials And Methods: Of the 40 participating patients, 20 did not undergo any reconstructive technique, whereas the remaining 20 patients underwent reconstructive technique that included the combination of long urethral stump and anterior suspension suture. Body mass index (BMI) (kg/m), age, preoperative prostate-specific antigen (PSA) levels, prostate volume, Gleason score, D'Amico risk class, clinical stage, operation type and the application of either perioperative or postoperative reconstructive techniques, and the duration of catheterization were the parameters investigated. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2020.19234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051238PMC
February 2020

Impact of Preoperative Magnetic Resonance Imaging Anatomic Features on Urinary Continence Recovery after Laparoscopic Radical Prostatectomy.

Urol Int 2020 10;104(3-4):239-246. Epub 2020 Mar 10.

Department of Urology, Peking University Third Hospital, Beijing, China.

Purpose: To evaluate the impact of preoperative magnetic resonance imaging anatomic features on urinary continence recovery after laparoscopic radical prostatectomy (LRP).

Methods: We retrospectively analyzed 150 consecutive prostate cancer patients who underwent LRP between July 2015 and June 2018 in our institution. Patients reporting freedom from using safety pad (0 pads/day) were defined as urinary continent. Read More

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http://dx.doi.org/10.1159/000506021DOI Listing

Complications of transrectal prostate biopsy in our context. International multicenter study of 3350 patients.

Actas Urol Esp 2020 Apr 29;44(3):196-204. Epub 2020 Feb 29.

Hospital Arnau de Vilanova, Valencia, España.

Introduction: Prostate cancer is the most common visceral neoplasm in men and the second one in the United States with the highest mortality behind lung cancer and ahead of colorectal cancer. While prostate cancer mortality rates have been reduced in the United States, Austria, United Kingdom and France, 5-year survival rates have been incremented in Sweden, probably due to a higher diagnostic activity and non-lethal tumor detection. TRPB usually has low rates of serious complications, with a not negligible number of minor complications. Read More

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http://dx.doi.org/10.1016/j.acuro.2019.11.004DOI Listing

[20 years urethroplasty experience. Retrospective review and outcomes.]

Arch Esp Urol 2020 Mar;73(2):89-95

Servicio de Urología. Hospital Universitario de Cruces. Baracaldo. España.

Objective: To present the evolution in the diagnosis and treatment of urethral stricture, after performing 300 surgical procedures over urethral meatus,penile and bulbar urethra along 20 years, contrasting two surgical periods: from 1997-2006 to 2007-2016. MATERIAL AND METHODS: A retrospective review of495 medical records between 1997-2016 was conducted.All the patients treated with urethroplasty were included and those who under went internal urethrotomy,stents or dilatations plus those with strictures due to prostate cancer treatment or orthotopic neobladder were excluded. Read More

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Second generation of temporary implantable nitinol device (iTind) in men with LUTS: 2 year results of the MT-02-study.

World J Urol 2020 Mar 2. Epub 2020 Mar 2.

Division of Urology, San Luigi Hospital, Orbassano, Italy.

Objectives: Assessing medium-term functional results of a novel minimally-invasive treatment for lower urinary tract symptoms due to BPO with the second generation of the temporary implantable nitinol device (iTind; Medi-Tate Ltd, Israel): 2-year follow-up of a single-arm, prospective, international multicenter study. Further, we aimed to identify preoperative baseline parameters predicting response to iTind treatment.

Methods: Following local ethical committee approval in every participating centre, 81 men with symptomatic BPO (IPSS ≥ 10, peak urinary flow < 12 ml/s, and prostate volume < 75 ml) were enrolled in this study. Read More

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http://dx.doi.org/10.1007/s00345-020-03140-zDOI Listing

Neoadjuvant Radiation with Concurrent 5-FU Resulting in Complete Pathologic Response in Stage IIIB Squamous Cell Carcinoma of the Urethra.

Case Rep Oncol Med 2020 14;2020:7948538. Epub 2020 Feb 14.

Division of Medical Oncology, MD Anderson Cancer Center, USA.

Squamous cell carcinoma (SCC) of the urethra is a rare malignancy, comprising less than 1% of all malignancies. The annual age-adjusted incidence of urethral SCC is 4.3 per million in men and 1. Read More

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http://dx.doi.org/10.1155/2020/7948538DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042525PMC
February 2020

Management of erectile dysfunction and LUTS/incontinence: the two most common, long-term side effects of prostate cancer treatment.

Can J Urol 2020 Feb;27(1S1):17-24

Division of Urology, University Health Network, University of Toronto, Toronto, Ontario, Canada.

The two major long-term concerns associated with different options for the management of prostate cancer, (including surgery, radiotherapy, brachytherapy, cryotherapy, HIFU, etc.) include difficulties with lower urinary tract symptoms (LUTS) and/or erectile dysfunction. LUTS can be in the form of stress urinary incontinence (SUI), urge urinary incontinence (UUI), frequency/urgency, and/or voiding difficulties. Read More

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February 2020

French ccAFU guidelines – Update 2018–2020: Bladder cancer

Prog Urol 2019 09;28(S1):R48-R80

Comité de cancérologie de l’Association française d’urologie, groupe vessie, maison de l’urologie, 11, rue Viète, 75017 Paris, France

Objective: To propose updated French guidelines for non-muscle invasive (NMIBC) and muscle-invasive (MIBC) bladder cancers.

Methods: A Medline search was achieved between 2015 and 2018, as regards diagnosis, options of treatment and follow-up of bladder cancer, to evaluate different references with levels of evidence.

Results: Diagnosis of NMIBC (Ta, T1, CIS) is based on a complete deep resection of the tumor. Read More

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http://dx.doi.org/10.1016/j.purol.2019.01.006DOI Listing
September 2019

Target motion mitigation promotes high-precision treatment planning and delivery of extreme hypofractionated prostate cancer radiotherapy: Results from a phase II study.

Radiother Oncol 2020 Feb 19;146:21-28. Epub 2020 Feb 19.

The Champalimaud Centre for the Unknown, Lisbon, Portugal; Memorial Sloan Kettering Cancer Center, New York, USA.

Background And Purpose: While favourable long-term outcomes have been reported in organ-confined prostate cancer treated with 5 × 7-8 Gy extreme hypofractionation, dose escalation to 5 × 9-10 Gy improved local control but was associated with unacceptable rates of late rectal and urinary toxicities. The purpose of this study was to explore the feasibility of intra-fractional prostate immobilization in reducing toxicity, to promote dose escalation with extreme hypofractionated radiotherapy in prostate cancer.

Material And Methods: 207 patients received 5 consecutive fractions of 9 Gy. Read More

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http://dx.doi.org/10.1016/j.radonc.2020.01.029DOI Listing
February 2020

Buccal mucosal graft urethroplasty for radiation-induced urethral strictures: an evaluation using the extended Urethral Stricture Surgery Patient-Reported Outcome Measure (USS PROM).

World J Urol 2020 Feb 18. Epub 2020 Feb 18.

Department of Urology, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.

Objectives: To evaluate objective treatment success and subjective patient-reported outcomes in patients with radiation-induced urethral strictures undergoing single-stage urethroplasty.

Patients And Methods: Monocentric study of patients who underwent single-stage ventral onlay buccal mucosal graft urethroplasty for a radiation-induced stricture between January 2009 and December 2016. Patients were characterized by descriptive analyses. Read More

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http://dx.doi.org/10.1007/s00345-020-03102-5DOI Listing
February 2020

Continent cutaneous ileocecal cystoplasty in the treatment of refractory bladder neck contracture and urinary incontinence after prostate cancer treatment.

Can J Urol 2020 Feb;27(1):10093-10098

Department of Surgery, Division of Urology and Urologic Oncology, City of Hope National Medical Center, Duarte, California, USA.

Introduction: To assess the use, complications, and outcomes of continent cutaneous ileocecal cystoplasty (CCIC) for the management of refractory bladder neck contractures and/or urinary incontinence after prostate cancer therapy.

Materials And Methods: An institutional review board approved database was reviewed for patients who underwent CCIC from January 1, 2003 to December 31, 2018. Preoperative, perioperative and postoperative factors were assessed, including complications and outcomes. Read More

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February 2020

Post-conization cervical stenosis treated with silicone catheter in microinvasive cervical cancer patient: A case report.

Int J Surg Case Rep 2020 6;67:95-97. Epub 2020 Feb 6.

Department of Maternal, Infantile, and Urological Sciences, University of Rome "Sapienza", Umberto I Hospital, Viale del Policlinico 155, 00161 Rome, Italy.

Introduction: Cervical stenosis can represent a hard complication to treat after conization for microinvasive cervical cancer.

Presentation Of Case: A young woman with cervical stenosis post-trachelectomy for a microinvasive cervical cancer came to our Department. We introduced a silicone catheter of 18 French in cervical canal. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.02.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013100PMC
February 2020

[Anastomosis stenosis after radical prostatectomy and bladder neck stenosis after benign prostate hyperplasia treatment: reconstructive options].

Urologe A 2020 Apr;59(4):398-407

Klinik für Urologie, Asklepios Klinik Barmbek, Rübenkamp 220, 22307, Hamburg, Deutschland.

Bladder neck stenosis (BNS) after simple prostatectomy and vesicourethral anastomosis stenosis (VUAS) after radical prostatectomy for prostate cancer are common sequelae. However, the two entities differ in their pathology, anatomy and their surgical results. VUAS has an incidence of 0. Read More

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http://dx.doi.org/10.1007/s00120-020-01143-7DOI Listing

Robotic urethral reconstruction: redefining the paradigm of posterior urethroplasty.

Transl Androl Urol 2020 Feb;9(1):121-131

Department of Urology, Mayo Clinic, Rochester, MN, USA.

Outlet procedures for benign prostatic hypertrophy, prostate cancer therapy, and trauma can result in stenosis of the posterior urethra, a complex reconstructive problem that often fails conservative endoscopic management, necessitating more aggressive and definitive reconstructive solutions. This is typically done with an open technique which may require a combined abdominoperineal approach, pubectomy, and/or flap interposition. Implementation of a robot-assisted platform affords several potential advantages including smaller incisions, magnified field of vision, near-infrared fluorescence (NIRF) imaging to characterize tissue integrity, enhanced dexterity within the deep and narrow confines of the male pelvis, sparing of the perineal planes, and shorter convalescence. Read More

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http://dx.doi.org/10.21037/tau.2019.08.22DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995938PMC
February 2020

Highlighting the importance of multidisciplinary approach: A rare case of primary periurethral poorly differentiated carcinoma.

Taiwan J Obstet Gynecol 2020 Jan;59(1):150-153

3rd Department of Obstetrics and Gynaecology, Hippokration General Hospital, Aristotle University of Thessaloniki, Greece.

Objective: Tumors in the periurethral area can be a rare clinical entity with many difficulties not only in the diagnosis, as well as in the treatment plan. Skene's gland adenocarcinoma accounts for less than 0.003% of all female urethral malignant neoplasms. Read More

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http://dx.doi.org/10.1016/j.tjog.2019.11.025DOI Listing
January 2020

The Efficacy of Second-line Chemotherapy for Advanced or Metastatic Urothelial Cancer.

Anticancer Res 2020 Feb;40(2):1141-1146

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Background/aim: This study aimed to assess the efficacy and toxicity of second-line chemotherapy, especially combination chemotherapy, for advanced or metastatic urothelial cancer.

Patients And Methods: This retrospective analysis included patients who received second-line chemotherapy after disease progression during first-line chemotherapy between January 2009 to May 2018. Progression-free survival (PFS), overall survival (OS) and toxicity associated with second-line chemotherapy were assessed. Read More

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http://dx.doi.org/10.21873/anticanres.14055DOI Listing
February 2020

The effect of holmium laser resection versus standard transurethral resection on non-muscle-invasive bladder cancer: a systematic review and meta-analysis.

Lasers Med Sci 2020 Jan 31. Epub 2020 Jan 31.

Department of Urology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400000, China.

To explore the advantages and limitations of holmium laser resection of the bladder tumor (HOLRBT) versus standard transurethral resection of the bladder tumor (TURBT) in the treatment of non-muscle-invasive bladder cancer (NMIBC), the eligible studies were selected from the following databases: PubMed, Cochrane Library, and Embase. Studies comparing HOLRBT and TURBT for patients with NMIBC were included. The outcomes of interest were time of operation, catheterization and hospitalization, rates of recurrence, and perioperative complications, including obturator nerve reflex, bladder perforation, bladder irritation, and urethral stricture. Read More

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http://dx.doi.org/10.1007/s10103-020-02972-wDOI Listing
January 2020

Does urethral length affect continence outcomes following robot assisted laparoscopic radical prostatectomy (RALP)?

BMC Urol 2020 Jan 31;20(1). Epub 2020 Jan 31.

South Terrace Urology, Adelaide, South Australia, Australia.

Background: Post-operative urinary incontinence is a significant concern for patients choosing to undergo a radical prostatectomy (RP) for treatment of prostate cancer. The aim of our study was to determine the effect of pre-operative MUL on 12 month continence outcomes in men having robot-assisted laparoscopic prostatectomy (RALP).

Methods: We use the South Australian Prostate Cancer Clinical Outcomes Collaborative (SA-PCCOC) database, to identify 602 patients who had undergone RALP by a high volume surgeon. Read More

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http://dx.doi.org/10.1186/s12894-020-0578-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995073PMC
January 2020