2,388 results match your criteria Ureteropelvic Junction Obstruction


A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study.

J Pediatr Urol 2020 Jun 11. Epub 2020 Jun 11.

Center for Vascular Biology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA. Electronic address:

Introduction And Objective: Reliable urinary biomarker proteins would be invaluable in identifying children with ureteropelvic junction obstruction (UPJO) as the existing biomarker proteins are inconsistent in their predictive ability. Therefore, the aim of this study was to identify consistent and reliable urinary biomarker proteins in children with UPJO.

Methods: To identify candidate biomarker proteins, total protein from age-restricted (<2 years) and sex-matched (males) control (n = 22) and UPJO (n = 21) urine samples was analyzed by mass spectrometry. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.163DOI Listing

Best ultrasound parameter for prediction of adverse renal function outcome after pyeloplasty.

Int J Urol 2020 Jul 1. Epub 2020 Jul 1.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Objective: To evaluate the clinical value of preoperative ultrasound parameters for post-pyeloplasty outcomes in pediatric patients with ureteropelvic junction obstruction.

Methods: The medical records of 187 pediatric and adolescent patients who underwent pyeloplasty as a result of ureteropelvic junction obstruction between 2010 and 2016 were retrospectively reviewed. The severity of hydronephrosis was measured by the Society for Fetal Urology grade, anteroposterior pelvic diameter, urinary tract dilation, hydronephrosis index, and the hydronephrosis area to renal parenchyma ratio at 3, 6 and 12 months. Read More

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http://dx.doi.org/10.1111/iju.14299DOI Listing

[Transurethral endopyelotomy using thulium fiber laser].

Urologiia 2020 Jun(3):63-68

Department of Urology and Andrology of A.I. Burnazyan SRC FMBC, FMBA of Russia, GBUZ City clinical hospital named after D.D. Pletnev of the Health Department c. Moscow, Moscow, Russia.

Introduction: Transurethral endopyelotomy is an alternative treatment method for short stricture of ureteropelvic junction (UPJ).

Aim: to evaluate the efficiency of transurethral thulium laser endopyelotomy.

Materials And Methods: A total of 94 patients with UPJ obstruction during the period from December 2016 to December 2018 were prospectively enrolled in the study. Read More

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Point-of-care ultrasound is an accurate, time-saving, and cost-effective modality for post-operative imaging after pyeloplasty.

J Pediatr Urol 2020 May 29. Epub 2020 May 29.

Division of Pediatric Urology, UPMC Children's Hospital of Pittsburgh, 4401 Penn Avenue, Pittsburgh, PA, USA 15224.

Background: Dismembered pyeloplasty is considered the gold standard treatment for ureteropelvic junction obstruction (UPJO). Although the frequency and timing of follow up imaging after pyeloplasty is variable, renal ultrasound (RUS) is commonly utilized. With minimal training, point-of-care ultrasound (POCUS) can be easily performed by a urologist during a post-operative visit. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.05.156DOI Listing

Robot-assisted Pyeloureterostomy in the Treatment of the Lower Pole Ureteropelvic Junction Obstruction in an Incomplete Duplicated System.

Urology 2020 Jun 16. Epub 2020 Jun 16.

Division of Urology, University of São Paulo Medical School, Sao Paulo, Brazil; Hospital Moriah, São Paulo, Brazil.

Purpose: To describe the surgical treatment of a patient harboring a ureteropelvic junction obstruction (UPJO) in the lower unit of an incomplete duplicated collecting system.

Methods: A female patient with 32-years old presented a progressively increasing left lumbar pain for 1 year and urinary tract infections (UTI) for the past 10 years. Computed tomography demonstrated a UPJO in the lower unit of an incomplete duplicated urinary collecting system. Read More

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http://dx.doi.org/10.1016/j.urology.2020.05.071DOI Listing

Utility of ultrasound elastography in postoperative follow-up of children with unilateral ureteropelvic junction obstruction.

Indian J Urol 2020 Apr-Jun;36(2):101-105. Epub 2020 Apr 7.

Department of Paediatric Urology, Sri Ramachandra Medical College and Research Institute, Chennai, Tamil Nadu, India.

Introduction: We aimed to determine whether shear wave velocity (SWV) on ultrasound elastography is useful in follow-up of children with ureteropelvic junction obstruction (UPJO) following pyeloplasty.

Methods: Consecutive children with unilateral UPJO who were co-operative for elastography ( = 31) were included. SWV of normal kidney was used as control, and it was compared with that of the affected kidney (UPJO) in the same patient. Read More

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http://dx.doi.org/10.4103/iju.IJU_379_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279094PMC

A 7-Year-Old Boy With Recurring Episodes of Abdominal Pain.

Pediatr Emerg Care 2020 Jul;36(7):e411-e413

Department of Emergency Medicine, Mercy St Vincent Hospital, Toledo, OH.

Recurrent abdominal pain is a relatively common complaint in children who present to the emergency department. The etiology is often thought to be psychogenic, with an underlying organic cause present in less than 10% of patients. Intermittent ureteropelvic junction obstruction is usually not considered in the differential diagnosis of recurrent acute abdominal pain in children, which can cause a significant delay in diagnosis. Read More

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http://dx.doi.org/10.1097/PEC.0000000000002158DOI Listing

Our experience on management of failed pediatric pyeloplasty.

Pediatr Surg Int 2020 Aug 15;36(8):971-976. Epub 2020 Jun 15.

Faculty of Medicine, Department of Urology, Division of Pediatric Urology, Hacettepe University, Ankara, Turkey.

Purpose: The purpose of the study was to assess the outcomes of salvage procedures after failed pediatric pyeloplasty. Recurrent ureteropelvic junction obstruction treatment is a difficult course. The salvage surgery is more challenging in the pediatric population. Read More

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http://dx.doi.org/10.1007/s00383-020-04699-9DOI Listing

Managing Ureteropelvic Junction Obstruction in the Young Infant.

Front Pediatr 2020 27;8:242. Epub 2020 May 27.

University of Texas Southwestern Medical Center, Dallas, TX, United States.

In the last decade, management of congenital UPJ obstruction has become progressively observational despite the lack of precise predictors of outcome. While it is clear that many children will have resolution of their hydronephrosis and healthy kidneys, it is equally clear that there are those in whom renal functional development is at risk. Surgical intervention for the young infant, under 6 months, has become relatively infrequent, yet can be necessary and poses unique challenges. Read More

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http://dx.doi.org/10.3389/fped.2020.00242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7267033PMC

Severe ureteropelvic junction obstruction with massive hydronephrosis causing compression of the inferior vena cava.

Urol Case Rep 2020 Sep 20;32:101272. Epub 2020 May 20.

Children's Hospital of Los Angeles, Division of Pediatric Urology, Los Angeles, CA, USA.

A 7-week-old girl presented with tachypnea and abdominal distension. Abdominal ultrasonography demonstrated a 16 cm cystic mass in the right abdomen. Contrast-enhanced T2-weighted magnetic resonance imaging revealed severe hydronephrosis of the right kidney with thinning of the renal parenchyma consistent with a massive ureteropelvic junction (UPJ) obstruction. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248421PMC
September 2020

Use of retrograde pyelogram to plan for miniature open incision in pediatric pyeloplasty.

J Pediatr Urol 2020 Apr 30. Epub 2020 Apr 30.

Division of Pediatric Urology, Riley Hospital for Children at IU Health, 705 Riley Hospital Dr., Suite 4230, Indianapolis, IN, 46202, USA. Electronic address:

Introduction: As robotic-assisted surgery becomes increasingly utilized for pediatric ureteropelvic junction (UPJ) obstruction, open surgeons have countered by using muscle-splitting, miniature (≤2 cm) incisions. To prepare for this type of incision during pyeloplasty, it is necessary to define the exact location of the UPJ. The use of retrograde pyelogram (RPG) at the time of pyeloplasty helps the surgeon to identify the exact location of UPJ, and thus be able to use a muscle-splitting, miniature incision for open pyeloplasty. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.04.022DOI Listing

Physician perspectives on discussions with parents of infants with suspected ureteropelvic junction obstruction.

J Pediatr Surg 2020 Apr 29. Epub 2020 Apr 29.

Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Introduction: The purpose of this study was to understand pediatric urologists' perceived role of patient characteristics on discussions about treatment of infants with suspected UPJ obstruction.

Methods: We conducted semi-structured interviews with pediatric urologists from three geographically diverse sites. Interview domains included: clinical indications for surgery, discussions with parents, and consideration of parent socioeconomic factors. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.04.016DOI Listing

Safety and Efficacy of Retrograde Pyeloperfusion for Ureteral Protection during Renal Tumor Cryoablation.

J Vasc Interv Radiol 2020 May 23. Epub 2020 May 23.

Department of Urology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905.

Purpose: To determine safety and efficacy of retrograde pyeloperfusion for ureteral protection during cryoablation of adjacent renal tumors.

Materials And Methods: Retrospective review of 155 patients treated with renal cryoablation, including adjunctive retrograde pyeloperfusion, from 2005 to 2019 was performed. Ice contacted the ureter in 67 of the 155 patients who represented the study cohort. Read More

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http://dx.doi.org/10.1016/j.jvir.2019.11.039DOI Listing

Minimally invasive open pyeloplasty in children: Long-term follow-up.

Turk J Urol 2020 May 21. Epub 2020 May 21.

Kidney Transplantation Research Center, Isfahan University of Medical Sciences (IUMS), Isfahan, Iran.

Objective: Our aim was to report the long-term follow-up for minimally invasive open pyeloplasty in children.

Material And Methods: A total of 213 children with a mean age 16.33 months underwent miniature open pyeloplasty for ureteropelvic junction obstruction between January 2010 and May 2016. Read More

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http://dx.doi.org/10.5152/tud.2020.20011DOI Listing

iTRAQ-based proteomics and in vitro experiments reveals essential roles of ACE and AP-N in the renin-angiotensin system-mediated congenital ureteropelvic junction obstruction.

Exp Cell Res 2020 Aug 13;393(1):112086. Epub 2020 May 13.

Department of Urology, Nanfang Hospital, Southern Medical University, China. Electronic address:

Objective: Ureteropelvic junction obstruction (UPJO) is a common renal obstructive disorder, but its pathogenic mechanisms remain largely unclear. We aimed to investigate the potential involvement of the renin-angiotensin system in congenital UPJO pathogenesis.

Methods: Differentially expressed proteins in exosomes isolated from amniotic fluid of patients with congenital UPJO were characterized using iTRAQ (isobaric tags for relative and absolute quantification)-based proteomics. Read More

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http://dx.doi.org/10.1016/j.yexcr.2020.112086DOI Listing

The effect of intravenous human adipose-derived stem cells (hADSC) on transforming growth factor β1 (TGF-β1), collagen type 1, and kidney histopathological features in the unilateral ureteropelvic junction obstruction model of wistar rats.

Turk J Urol 2020 05 1;46(3):236-242. Epub 2020 May 1.

Department of Urology, Faculty of Medicine Universitas Padjadjaran, Dr. Hasan Sadikin General Hospital, Indonesia.

Objective: The fibrotic process of kidney resulting in glomerulosclerosis was found in patients with ureteropelvic junction obstruction (UPJO) who underwent renal biopsy during pyeloplasty. Transforming growth factor β1 (TGF-β1) plays a role in collagen accumulation, resulting in fibrosis. Adipose tissue-derived stem cells (ADSCs) have an anti-apoptotic effect on target cells and enhance the kidney function recovery. Read More

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http://dx.doi.org/10.5152/tud.2020.20024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219970PMC

A Large Cystic Abdominal Mass.

Gastroenterology 2020 May 1. Epub 2020 May 1.

From the Department of Internal Medicine and Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.04.068DOI Listing

Concomitant management of renal calculi and recurrent ureteropelvic junction obstruction with percutaneous nephrolithotomy and antegrade balloon dilation.

J Int Med Res 2020 May;48(5):300060520911252

Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong Province, China.

Objective: This study aimed to present our experience of concomitant management of renal calculi and recurrent ureteropelvic junction obstruction (UPJO) with percutaneous nephrolithotomy (PCNL) and antegrade balloon dilation.

Methods: We retrospectively reviewed 31 patients who underwent PCNL and antegrade balloon dilation for treatment of renal calculi and recurrent UPJO. The inclusion criterion was the presence of UPJO after failed pyeloplasty with ipsilateral renal calculi. Read More

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http://dx.doi.org/10.1177/0300060520911252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218938PMC

Serum-Targeted HILIC-MS Metabolomics-Based Analysis in Infants with Ureteropelvic Junction Obstruction.

J Proteome Res 2020 Jun 12;19(6):2294-2303. Epub 2020 May 12.

Paediatric Nephrology Unit, First Department of Paediatrics, Hippokratio Hospital, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.

Ureteropelvic junction obstruction (UPJO) constitutes the predominant cause of obstructive nephropathy in both neonates and infants. Fundamental questions regarding UPJO's mechanism, assessment, and treatment still remain unanswered. The aim of the present study was to elucidate potential differences through serum metabolic profiling of surgical cases of infants with UPJO compared to both nonsurgical cases and healthy age-matched controls. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00855DOI Listing

Do current scientific reports of hydronephrosis make the grade?

J Pediatr Urol 2020 Apr 10. Epub 2020 Apr 10.

Pediatric Urology The Children's Hospital of Michigan 3901 Beaubien Detroit, MI 48201, USA. Electronic address:

Background: In December 2014, Nguyen et al. introduced the Upper Tract Dilation (UTD) classification scheme, hoping to unify multiple disciplines when describing ultrasound imaging of congenital hydronephrosis. We hypothesized that the academic community has been slow to adopt its use in publications. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.04.003DOI Listing

Use of double-J ureteric stents post-laparoscopic pyeloplasty to treat ureteropelvic junction obstruction in hydronephrosis for pediatric patients: a single-center experience.

J Int Med Res 2020 Apr;48(4):300060520918781

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing, China.

Objectives: We aimed to investigate the safety concerns associated with placing double-J ureteric stents post-laparoscopic pyeloplasty surgery for congenital ureteropelvic junction obstruction (UPJO) and hydronephrosis.

Methods: A total of 1349 patients with postoperative double-J stent placement at our center were included. Clinical variables for enrolled patients were collected by two independent authors. Read More

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http://dx.doi.org/10.1177/0300060520918781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218463PMC
April 2020
1.095 Impact Factor

Primary laparoscopic pyeloplasty in children: A single-center experience of 279 patients and analysis of possible factors affecting complications.

J Pediatr Urol 2020 Jun 10;16(3):331.e1-331.e11. Epub 2020 Apr 10.

Department of Urology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. Electronic address:

Introduction: Laparoscopic pyeloplasty (LP) has been widely used in the treatment of pediatric ureteropelvic junction obstruction (UPJO). However, no prior reports with a large pediatric series have focused on the analysis of complications and impact factors of the outcomes. We hypothesized there were risk factors of higher Clavien grade postoperative complications. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.03.028DOI Listing

Forniceal Rupture in Neonate Masquerading as a Cystic Renal Mass.

Urology 2020 Apr 21. Epub 2020 Apr 21.

Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA; Division of Urology, Department of Surgery, Children's Hospital Los Angeles, Los Angeles, CA.

A 5-week-old full-term female with high-risk right hydronephrosis was transferred to the emergency department (ED) for tachypnea. A contrast-enhanced computed tomography (CT) study demonstrated a 9.0 cm cystic lesion in the region of the previously seen hydronephrosis (Fig. Read More

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http://dx.doi.org/10.1016/j.urology.2020.04.036DOI Listing

Guidelines of the Italian Society of Videosurgery in Infancy for the minimally invasive treatment of the ureteropelvic-junction obstruction.

Pediatr Med Chir 2019 Dec 19;41(2). Epub 2019 Dec 19.

Pediatric Surgery and Urologic Unit, Local Health Unit 8, S. Bortolo Hospital, Vicenza.

The hydronephrosis, characterized by the dilation of the renal pelvicalyceal system with possible functional damage to the renal parenchyma, is the most common congenital abnormality of the urinary system detected in utero through the prenatal ultrasound screening. (.. Read More

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http://dx.doi.org/10.4081/pmc.2019.232DOI Listing
December 2019

Embryology and Morphological (Mal)Development of UPJ.

Front Pediatr 2020 7;8:137. Epub 2020 Apr 7.

Gaziantep Maternity and Children's Hospital, Pediatric Urology, Gaziantep, Turkey.

Kidney parenchyma and collecting system arise from two different embryologic units as a result of a close interaction between them. Therefore, their congenital abnormalities are classified together under the same heading named CAKUT (congenital abnormalities of the kidney and urinary tract). The pathogenesis of CAKUT is thought to be multifactorial. Read More

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http://dx.doi.org/10.3389/fped.2020.00137DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7154125PMC

Safety and Efficiency of Pyeloplasty in The First Six Weeks of Infants' Life.

Urol J 2020 Apr 19. Epub 2020 Apr 19.

University of Health Sciences, Zeynep Kamil Maternity and Children's Diseases Health Training and Research Center, Department of the Pediatric Surgery, Istanbul, Turkey.

Purpose: The aim of this study was to assess the safety and the efficiency of pyeloplasty in infants with ureteropelvic junction obstruction (UPJO) in the first six weeks of their life.

Materials And Methods: Clinical records of the patients who had surgery during first six weeks of life for UPJO between June 2009 and June 2014 were analysed retrospectively.

Results: In this period, twenty-six dismembered pyeloplasties were performed in twenty-four patients on mean operation age of 27. Read More

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http://dx.doi.org/10.22037/uj.v0i0.5531DOI Listing
April 2020
0.707 Impact Factor

Intraoperative Decision-Making: Thermal Injury During Robotic Pyeloplasty.

Urology 2020 Jul 12;141:178. Epub 2020 Apr 12.

Department of Urology, University of Kentucky, Lexington, KY. Electronic address:

Objective: To describe how an intraoperative thermal injury to the ureter was handled during a robotic dismembered pyeloplasty.

Methods: The patient was a 5-year-old male who was undergoing robotic dismembered pyeloplasty for a symptomatic left ureteropelvic junction (UPJ) obstruction. The case started with cystoscopy and retrograde ureteral catheter placement prior to moving to the robotic part of the procedure. Read More

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http://dx.doi.org/10.1016/j.urology.2020.03.029DOI Listing

Impact of successful pediatric ureteropelvic junction obstruction surgery on urinary HIP/PAP and BD-1 levels.

J Pediatr Urol 2020 Mar 29. Epub 2020 Mar 29.

Division of Pediatric Urology, Department of Pediatric Surgery, Nationwide Children's Hospital, Columbus, OH, USA; Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Electronic address:

Introduction: In the pediatric patient whose ureteropelvic junction obstruction (UPJO) is not always symptomatic, imaging is the most common means of detecting surgical success. There is interest, however, in other means of post-operative monitoring. A panel of antimicrobial peptides (AMPs) has been previously found to be elevated in UPJO, but the impact of surgical correction on these AMPs is unknown. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.03.006DOI Listing

Comparative Proteome Analyses of Ureteropelvic Junction Obstruction and Surrounding Ureteral Tissue.

Cells Tissues Organs 2020 Apr 7:1-11. Epub 2020 Apr 7.

Department of Pediatric Surgery, Faculty of Medicine, Istanbul Bilim University, Istanbul, Turkey.

Ureteropelvic junction (UPJ) obstruction is a common problem in children, but its etiology remains unclear. In this study, the proteome profiles of the obstructed segment and its surrounding distal and proximal parts were comparatively evaluated. Twelve children younger than 2 years of age with unilateral intrinsic UPJ obstruction were included. Read More

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http://dx.doi.org/10.1159/000506736DOI Listing

Robotic dismembered pyeloplasty surgical simulation using a 3D-printed silicone-based model: development, face validation and crowdsourced learning outcomes assessment.

J Robot Surg 2020 Apr 2. Epub 2020 Apr 2.

Boston Medical Center, Boston University School of Medicine, 725 Albany St., Suite 3B, Boston, MA, 02118, USA.

Ureteropelvic junction obstruction (UPJO) is an uncommonly encountered pathology, posing a challenge for resident training. We describe the development and face validation of a robotic pyeloplasty simulation using a 3D-printed silicone-based model of UPJO for surgical training, in combination with crowdsourced scoring to objectively assess performance and learning outcomes. The organs were created using 3D modeling software and printed using a silicone-based material by Lazarus 3D, LLC. Read More

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http://dx.doi.org/10.1007/s11701-020-01072-9DOI Listing

Robot-assisted laparoscopic pyelotomy and ileal ureter substitution: video demonstration.

J Pediatr Urol 2020 Apr 20;16(2):255. Epub 2020 Feb 20.

Division of Urology, Ann & Robert H. Lurie Children's Hospital of Chicago, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jpurol.2020.01.013DOI Listing

CT imaging findings of abdominopelvic vascular compression syndromes: what the radiologist needs to know.

Insights Imaging 2020 Mar 17;11(1):48. Epub 2020 Mar 17.

Sezione di Scienze Radiologiche, Biomedicina, Neuroscienze e Diagnostica avanzata (BIND), University of Palermo, Via del Vespro 129, 90127, Palermo, Italy.

Abdominopelvic vascular compression syndromes include a variety of uncommon conditions characterized by either extrinsic compression of blood vessels by adjacent anatomical structures (i.e., median arcuate ligament syndrome, nutcracker syndrome, May-Thurner syndrome) or compression of hollow viscera by adjacent vessels (i. Read More

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http://dx.doi.org/10.1186/s13244-020-00852-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078419PMC

Delayed Rupture of the Renal Collecting System Secondary to a Traumatic Hemorrhage in the Setting of Suspected Chronic Ureteropelvic Junction Obstruction.

J Radiol Case Rep 2020 Jan 31;14(1):12-20. Epub 2020 Jan 31.

Department of Radiology, Saint Louis University Hospital, Saint Louis, USA.

Isolated rupture of the renal pelvis secondary to blunt trauma is rare, though there is increased incidence in the setting of a pre-existing renal abnormality that predisposes the kidney to injury. We report a case of post-traumatic hemorrhage into the renal collecting system leading to delayed rupture of the renal pelvis in the setting of suspected chronic ureteropelvic junction obstruction. This case illustrates the difficulty in diagnosis of acute hemorrhage into the renal collecting system. Read More

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http://dx.doi.org/10.3941/jrcr.v14i1.3067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7060004PMC
January 2020

Open Surgery in the Era of Minimally Invasive Surgery: Pyeloplasty via A Mini Flank Incision in the Treatment of Infants with Ureteropelvic Junction Obstruction.

Urol J 2020 Mar 16;17(2):169-172. Epub 2020 Mar 16.

Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Purpose: To evaluate the clinical effects of open pyeloplasty via a mini flank incision in the treatment of infants with ureteropelvic junction obstruction (UPJO).

Materials And Methods: We retrospectively analyzed 85 cases of infants with UPJO in our hospital from Jan. 2015 to Jan. Read More

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http://dx.doi.org/10.22037/uj.v0i0.5405DOI Listing

Design and validation of a low-cost, high-fidelity model for robotic pyeloplasty simulation training.

J Pediatr Urol 2020 Jun 12;16(3):332-339. Epub 2020 Feb 12.

University of Texas Southwestern Medical School, Dallas, TX, USA. Electronic address:

Introduction/background: Owing to restrictions in operative experiences, urology residents can no longer solely rely on 'hands-on' operative time to master their surgical skills by the end of residency. Simulation training could help residents master basic surgical skills and steps of a procedure to maximize time in the operative room. However, simulators can be expensive or tedious to set up, limiting the availability to residents and training programs. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.02.003DOI Listing

Pediatric congenital hydronephrosis (ureteropelvic junction obstruction): Medical management guide.

Int J Urol 2020 May 11;27(5):369-376. Epub 2020 Mar 11.

Committee for the Formulation of Medical Management Guide for Pediatric Congenital Hydronephrosis (ureteropelvic junction obstruction), Academic Committee, Japanese Society of Pediatric Urology, Osaka, Japan.

The prevalence of asymptomatic hydronephrosis, now detected by ultrasonography, has increased. However, definitive management guidelines for the management of congenital hydronephrosis have not been established. The Japanese Society of Pediatric Urology created a "medical management guide" based on new findings for physicians practicing pediatric urology. Read More

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http://dx.doi.org/10.1111/iju.14207DOI Listing

Color Doppler Ultrasonography in Evaluating the Outcomes of Pyeloplasty in Ureteropelvic Junction Obstruction.

Res Rep Urol 2020 24;12:53-59. Epub 2020 Feb 24.

Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.

Purpose: To evaluate the accuracy of Color Doppler ultrasonography for diagnosing post pyeloplasty elimination of obstruction in Ureteropelvic Junction Obstruction patients.

Methodology: Patients with the diagnosis of UPJO enrolled in the study and underwent open pyeloplasty. Three to 6 months after the operation, patients were recalled and underwent isotope scan as the gold standard test and renal color Doppler ultrasonography to assess the success rate of pyeloplasty. Read More

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http://dx.doi.org/10.2147/RRU.S227046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7047967PMC
February 2020

Changes in differential renal function after pyeloplasty in infants and children.

J Pediatr Urol 2020 Jun 11;16(3):329.e1-329.e8. Epub 2020 Feb 11.

Dpt of Pediatric Surgery, The Pediatric Uronephrologic Center at the Queen Silvia Childrens Hospital, Institution of Clinical Sciences, The Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address:

Introduction: Ureteropelvic junction obstruction (UPJO) is one of the most common causes of hydronephrosis in pediatric populations. Many need surgical intervention. The aim of surgery is preserving renal function and reducing symptoms such as urinary tract infections and pain. Read More

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http://dx.doi.org/10.1016/j.jpurol.2020.02.002DOI Listing

Robot-assisted laparoscopic pyeloplasty for ureteropelvic junction obstruction with duplex system.

Urol Case Rep 2020 May 21;30:101138. Epub 2020 Feb 21.

Akita University Graduate School of Medicine, Department of Urology, Japan.

Management of ureteropelvic junction obstruction with a duplex system is technically challenging even when laparoscopic procedure is the standard approach for ureteropelvic junction obstruction. The patient was an otherwise healthy 21-year-old woman who presented with symptomatic ureteropelvic junction obstruction with the duplex system, which was completely excised using a robot-assisted approach. Robotic assistance allows for proper tissue dissection, minimal manipulation of the normal ureter, and meticulous fine suturing and would overcome the potential challenges involved in the minimally invasive management of such complex anomalies as shown in this patient. Read More

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http://dx.doi.org/10.1016/j.eucr.2020.101138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044749PMC

Renal Hemodynamic Changes and Postsurgical Recovery in Children Treated for Ureteropelvic Junction Obstruction.

Ultrasound Q 2020 Mar;36(1):20-23

Department of Pediatric Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Objective: The aims of the study were to measure renal hemodynamic indexes and to evaluate postsurgical recovery in children diagnosed with obstructive hydronephrosis using color Doppler ultrasound.

Methods: This study enrolled 36 patients with ureteropelvic junction obstruction who underwent Anderson-Hynes pyeloplasty. The peak systolic velocity (PSV) and the resistive index (RI) of the main renal arteries (MRAs) and interlobar renal arteries (IRAs) were measured using color Doppler ultrasound. Read More

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http://dx.doi.org/10.1097/RUQ.0000000000000477DOI Listing

Altered anoctamin-1 and tyrosine phosphorylation in congenital ureteropelvic junction obstruction.

J Pediatr Surg 2020 Feb 11. Epub 2020 Feb 11.

National Children's Research Centre, Our Lady's Children's Hospital, Dublin, Ireland; School of Medicine and Medical Science and Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland. Electronic address:

Purpose: Ureteropelvic junction (UPJ) obstruction is the most common cause of congenital hydronephrosis in children. The pathophysiology of UPJ obstruction and the exact mechanism of pelviureteral peristalsis are poorly understood. Anoctamin-1 (ANO1), a Ca-activated chloride channel, has been shown to play a key role in muscle wall contractions in the gastrointestinal tract. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.02.001DOI Listing
February 2020

Bilateral aniridia and congenital ureteral valve: Role of genetic testing.

Mol Genet Genomic Med 2020 Apr 14;8(4):e1183. Epub 2020 Feb 14.

Norton Children's Urology, Norton Healthcare, Louisville, KY, USA.

Background: Congenital aniridia involves total or partial hypoplasia of the iris and is due to a deficiency in PAX6 gene expression. WAGR syndrome is comprised of Wilms tumor, aniridia, genitourinary abnormalities, and intellectual disability. Numerous genitourinary pathologies may be associated with WAGR syndrome, necessitating an evaluation of the genitourinary anatomy. Read More

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http://dx.doi.org/10.1002/mgg3.1183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7196450PMC

The expression of platelet-derived growth factor receptor alpha-positive cells in the stenotic tissue of ureteropelvic junction obstruction in children
.

Clin Nephrol 2020 Apr;93(4):195-202

Aim: By observing the expression and distribution of platelet-derived growth factor receptor α-positive (PDGFRα) cells in ureteropelvic junction obstruction (UPJO), to explore their role in the pathogenesis of children with congenital hydronephrosis.

Materials And Methods: The control group involved specimens of the normal ureter (nephrectomy for tumor; n = 10), and the UPJO group contained specimens of ureteropelvic junction (UPJ) segment excised during pyeloplasty (n = 30). The specimens were investigated using immunofluorescence for the expression and distribution of PDGFRα cells in each group by light microscopy with computerized image analysis. Read More

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http://dx.doi.org/10.5414/CN110009DOI Listing

Factors affecting the effectiveness and success of retrograde holmium laser endopyelotomy as the primary treatment of ureteropelvic junction obstruction in adults.

Urologia 2020 Feb 12:391560320904259. Epub 2020 Feb 12.

Department of Urology, University of Health Sciences, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

Purpose: To evaluate the factors affecting the effectiveness, safety, and success of retrograde holmium:yttrium-aluminum-garnet laser endopyelotomy as the primary treatment of ureteropelvic junction obstruction in adults.

Methods: Adult patients who underwent retrograde holmium:yttrium-aluminum-garnet laser endopyelotomy as the primary treatment of ureteropelvic junction obstruction between January 2012 and June 2016 at our clinic were retrospectively analyzed. Success was defined as the relief of symptoms and the resolution of obstruction, as assessed via radiography. Read More

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http://dx.doi.org/10.1177/0391560320904259DOI Listing
February 2020

Pelvic ectopic solitary kidney: treatment with the application of three-dimensional computed tomography and laparoscopic pyeloplasty-a case report.

Transl Androl Urol 2019 Dec;8(6):754-757

Department of Urology, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100070, China.

Renal ectopia occurs in 1:3,000-1:7,000 children. Simple ectopia refers to the abnormal kidney location on the same side; in crossed ectopia the ureter crosses the midline of the body. Pelvic ectopic solitary kidney with hydronephrosis due to ureteropelvic junction obstruction (UPJO) is even rarer in clinical practice. Read More

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http://dx.doi.org/10.21037/tau.2019.12.02DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6987611PMC
December 2019

A systematic review of genitourinary injuries arising from rugby and football.

J Pediatr Urol 2020 Apr 7;16(2):130-148. Epub 2020 Jan 7.

Department of Surgery, University of Toronto, Toronto, Canada; Division of Urology, The Hospital for Sick Children, Toronto, Canada.

Background: Genitourinary injuries in athletes engaging in high-impact sports such as football and rugby may have catastrophic consequences, especially in individuals with pre-existing urologic concerns, such as a solitary kidney.

Objective: To summarize the current literature on football-related or rugby-related genitourinary organ injuries in both adult and pediatric populations in an effort to risk stratify the likelihood of these injuries.

Methods: An independent systematic literature search for records reporting football-related or rugby-related injuries was conducted by a certified librarian and reviewer in March 2019. Read More

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http://dx.doi.org/10.1016/j.jpurol.2019.12.019DOI Listing

[The Initial Results of Robot-Assisted Pyeloplasty in Comparison with Laparoscopic Pyeloplasty for Ureteropelvic Junction Obstruction].

Hinyokika Kiyo 2020 Jan;66(1):1-4

The Department of Urology, Akita University Graduate School of Medicine.

The initial results robot-assisted pyeloplasty (RAP) performed on 6 patients were compared with those of laparoscopic pyeloplasty (LP) for ureteropelvic junction obstruction performed on 26 patients in a Japanese regional center. The median operating time, estimated blood loss, time to oral intake, time to start walking, and hospital stay were not significantly different between the groups. There was no difference in the rate of complications of Clavien-Dindo≥grade III between the two groups. Read More

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http://dx.doi.org/10.14989/ActaUrolJap_66_1_1DOI Listing
January 2020

Risk Factors and Management Options for the Adult Failed Ureteropelvic Junction Obstruction Repair in the Era of Minimally Invasive and Robotic Approaches: A Comprehensive Literature Review.

J Endourol 2020 Mar 17. Epub 2020 Mar 17.

Division of Urology, Department of General Surgery, Rush University Medical Center, Chicago, Illinois.

Guidelines for the management of pyeloplasty failure remain elusive given the rarity of this condition and the difficulty of integrating and analyzing reported outcomes given the varying definition of failures. In this article, we aim to review the existing literature on risk factors that may influence the surgical outcomes of reconstructive pyeloplasty for ureteropelvic junction obstruction. Furthermore, we discuss management options and review success outcomes of treatment options for patients with pyeloplasty failure. Read More

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http://dx.doi.org/10.1089/end.2019.0737DOI Listing

Extracorporeal ureter handling during laparoscopic pyeloplasty: tips and tricks for beginners.

Cent European J Urol 2019 6;72(4):413-417. Epub 2019 Dec 6.

Institute for Urology and Reproductive Health, Sechenov University, Moscow, Russia.

Introduction: Laparoscopic preparation of the ureter is a challenging part of upper urinary tract reconstruction, due to limited depth perception provided by the camera and lack of wristed motion of most laparoscopic instruments needed for adequate spatulation and scar tissue removal. One solution has been to perform the more difficult portions of the surgery in an extracorporeal manner. A hybrid intracorporeal-extracorporeal approach to upper tract ureteral reconstruction facilitates ureteral preparation at the stage of mastering the technique. Read More

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http://dx.doi.org/10.5173/ceju.2019.0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979559PMC
December 2019

The learning curve for robotic-assisted pyeloplasty in children: Our initial experience from a single center.

Urol Ann 2020 Jan-Mar;12(1):19-24. Epub 2019 Dec 23.

Pediatric Urology Division, Surgery Department, Sidra Medical and Research Center, Doha, Qatar.

Background: Robotic-assisted pyeloplasty surgery has become the preferred approach of ureteropelvic junction obstruction (UPJO) in pediatrics. However, to our knowledge, there is limited data on the learning curve for robotic-assisted pyeloplasty in children and no similar study from Saudi Arabia.

Aims: The objective of the study was to evaluate the progression of the surgical team performing robotic-assisted laparoscopic pyeloplasty (RALP) and to assess the feasibility of the RALP in children, since it is having been recently started in the Kingdom. Read More

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http://dx.doi.org/10.4103/UA.UA_113_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978967PMC
December 2019