Search Our Scientific Publications & Authors

Toxics 2021 Apr 29;9(5). Epub 2021 Apr 29.

Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Subject of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China.

The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system. Read More

J Stroke Cerebrovasc Dis 2021 Feb 16:105652. Epub 2021 Feb 16.

University of California, Irvine, 101 The City Drive South, Bldg 3, Rt. 88, Irvine, CA 92697, United States.

Sleep apnea is a condition with significant health risks and increased risk of mortality and is prevalent in patients with chronic kidney disease. This paper describes the detrimental cardiovascular sequelae of sleep-disordered breathing and explores the bidirectional relationship between chronic kidney disease and obstructive sleep apnea. Obstructive sleep apnea-related hypoxia produces a range of harmful systemic effects including oxidative stress, inflammation, and sympathetic activation that collectively worsen the progression of renal disease. Read More

Front Pediatr 2020 16;8:570708. Epub 2020 Nov 16.

Department of Pediatrics, Faculty of Medicine, Menoufia University, Shebin El Kom, Egypt.

Patients with chronic kidney disease (CKD) on maintenance hemodialysis frequently present with neurological complications. These complications include peripheral neuropathy, encephalopathy, and stroke. To detect the prevalence of neurological manifestations and complications in children with CKD through neurophysiological and neuro-radiological findings. Read More

Saudi J Kidney Dis Transpl 2020 Sep-Oct;31(5):1106-1109

Department of Nephrology, Government Stanley Medical College, Chennai, Tamil Nadu, India.

A 28-year-old male, 10 years post live-related renal transplant with stable graft function of 1.4 mg/dL, presented with complaints of loss of appetite and vomiting for three days. On evaluation, he was found to have significant graft dysfunction with a creatinine of 10. Read More

J Stroke Cerebrovasc Dis 2020 Nov 13:105461. Epub 2020 Nov 13.

Division of Nephrology, Hypertension and Kidney Transplantation, Harold Simmons Center for Kidney Disease Research and Epidemiology, Division of Nephrology and Hypertension, University of California, Irvine, School of Medicine, 101 The City Drive South, City Tower, Suite 400, Orange, CA 92868, USA. Electronic address:

Objectives: Cerebrovascular disease has increasingly been linked to overall vascular health. Pathologic conditions like diabetes, hypertension, and kidney disease have been shown to affect brain health and cerebrovascular and nervous systems. Acute kidney injury (AKI) and chronic Kidney Disease (CKD) represent a variety of vascular insults that can adversely affect cerebral health. Read More

J Int Med Res 2020 Jul;48(7):300060520933797

Department of Biological Science, National Sun Yat-Sen University, Kaohsiung.

Objective: Cardiovascular autonomic neuropathy is highly prevalent in patients with end-stage renal disease (ESRD), and it has a high fatality rate. This study aimed to determine whether peritoneal dialysis (PD) improves cardiovascular autonomic function (CAF) and decreases protein-bound uremic toxin (indoxyl sulfate [IS], p-cresyl sulfate [PCS]) levels.

Methods: IS and PCS levels, and parameters of CAF (heart rate response to deep breathing [HR_DB], the Valsalva ratio, baroreflex sensitivity, and the frequency domain) were prospectively evaluated in 26 patients with ESRD undergoing PD at two time points (pre-PD and 6 months post-PD). Read More

Dis Markers 2020 19;2020:1694218. Epub 2020 May 19.

Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.

Background: Peripheral neuropathy is a common neurological complication in uremic patients, and quantitative sensory testing (QST) is effective for diagnosis of small fiber neuropathy. Malnutrition and arterial stiffness are prevalent in patients undergoing hemodialysis (HD). The associations of small fiber neuropathy with nutritional status and arterial stiffness remain uncertain in maintenance HD patients. Read More

Ann Med Surg (Lond) 2020 Jul 16;55:107-110. Epub 2020 May 16.

Urologist, Duhok Directorate General of Health, Kurdistan Region, Iraq.

Introduction: Sexual dysfunction is a common problem in patients with chronic kidney disease. Disturbances in sexual function are noticed in early stages of chronic kidney diseases and deteriorate further as renal function declines. This is due to uremic effects, comorbid illness, anemia, hormonal disturbances, autonomic neuropathy, vascular diseases, hyperparathyroidism, hyperprolactinemia, side effects of medications, and psychosocial factors. Read More

Clin Rheumatol 2020 Feb 23;39(2):541-546. Epub 2019 Nov 23.

Sorbonne Université, Service de médecine interne, DHU i2B AP-HP, Hôpital Saint Antoine, 75012, Paris, France.

Transfusion-related acute lung injury (TRALI), defined as the onset of acute respiratory distress after blood transfusion, is a rare complication which is a leading cause of transfusion related-mortality. In this retrospective study, we report the French nationwide experience of intravenous immunoglobulin (IVIG)-related TRALI, with a literature review and analysis of management and outcome of this rare condition. With the pharmacovigilance services, we conducted a retrospective multicenter study in the French network of intensive care units with TRALI concomitant to IVIG use and pooled with data from a literature review. Read More

Medicine (Baltimore) 2019 Sep;98(39):e17232

Department of Ophthalmology.

Rationale: To report a rare case of severe atypical hemolytic-uremic syndrome (HUS) in a patient who presented with vitreous hemorrhage and tractional retinal detachment (TRD) in both eyes. To our knowledge, this is the first reported case of atypical HUS complicated with bilateral TRD in the literature.

Patient Concerns: A 20-year-old man with atypical HUS demonstrated bilateral visual acuity of hand motion at 30 cm. Read More

J Assoc Physicians India 2019 Aug;67(8):90-91

Assistant Professor, JLN Medical College, Ajmer, Rajasthan.

A 55 yr old diabetic lady suffered a posterior wall STEMI. She developed Contrast induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan Barre Syndrome, hence reported. Read More

Mol Pain 2019 Jan-Dec;15:1744806919881038

Peripheral Neuropathy Unit, Centre for Clinical Translation, Department of Medicine, Imperial College London, Hammersmith Hospital, London, UK.

Clin Neurophysiol 2019 11 22;130(11):2088-2095. Epub 2019 Aug 22.

Prince of Wales Clinical School, UNSW Sydney, NSW 2031, Australia. Electronic address:

Objective: Chronic kidney disease (CKD) caused by diabetes is known as diabetic kidney disease (DKD). The present study aimed to examine the underlying mechanisms of axonal dysfunction and features of neuropathy in DKD compared to CKD and type 2 diabetes (T2DM) alone.

Methods: Patients with DKD (n = 30), CKD (n = 28) or T2DM (n = 40) and healthy controls (n = 41) underwent nerve excitability assessments to examine axonal function. Read More

J Assoc Physicians India 2018 Jun;66(6):31-37

Professor of Neurology, SVIMS, Tirupati, Andhra Pradesh.

Objective: To study the prevalence, clinical features, electrophysiological features and severity of peripheral neuropathy in chronic kidney disease (CKD) patients.

Methods: Between May 2015 and December 2016, 200 CKD patients and 25 controls were assessed prospectively.

Results: Prevalence of peripheral neuropathy in CKD patients was 50% based on clinical symptoms and 89% based on electrophysiological studies. Read More

Case Rep Med 2019 3;2019:4172395. Epub 2019 Apr 3.

Teaching (General) Hospital Kandy, Kandy, Sri Lanka.

Envenomations by hump-nosed pit vipers (HNVs) are frequent in Sri Lanka and in South India. Until recently, HNV was considered a moderately venomous snake. Here, we report a case of a previously healthy female developing all the known serious complications, plus some previously unreported complications following a HNV envenomation. Read More

Rev Assoc Med Bras (1992) 2019 Mar 11;65(3):469-474. Epub 2019 Apr 11.

Department of Integrated Clinical Discussions, ABC Medical School, Santo André, SP, Brasil.

Introduction: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy (UN) is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate.

Objectives: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. Read More

Rev Assoc Med Bras (1992) 2019 Feb;65(2):281-286

Department of Integrated Clinical Discussions, ABC Medical School, Av. Príncipe de Gales, 821, CEP 09060-650, Santo André, SP, Brasil.

Introduction: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate.

Objectives: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. Read More

Expert Rev Clin Pharmacol 2019 Jan 11;12(1):61-90. Epub 2019 Jan 11.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic, and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

Kidney Int 2018 04;93(4):1021

Division of Nephrology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Neuroophthalmology 2017 Dec 10;41(6):321-325. Epub 2017 May 10.

Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.

Renal osteodystrophy can cause calvarial hypertrophy and narrowing of the neural canals and foramina. Compressive optic neuropathy is extremely rare in renal osteodystrophy and was reported once only. The authors report bilateral, simultaneous compressive optic neuropathy secondary to renal osteodystrophy with features of uremic leontiasis ossea in chronic renal failure caused by branchio-oto-renal syndrome. Read More

Hemodial Int 2018 04 11;22(2):150-160. Epub 2017 Aug 11.

Departments of Medicine, Physiology and Biophysics, Division of Nephrology and Hypertension, University of California, Irvine, USA.

Perhaps no other organ in the body is affected as often and in as many ways as the brain is in patients with chronic kidney disease (CKD). Several factors contribute to the neurological disorders in CKD including accumulation of uremic toxins, metabolic and hemodynamic disorders, oxidative stress, inflammation, and impaired blood brain barrier among others. The neurological disorders in CKD involve both peripheral and central nervous system. Read More

Semin Pediatr Neurol 2017 02 23;24(1):25-32. Epub 2016 Dec 23.

From the Department of Pediatrics, Division of Nephrology, Children׳s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Electronic address:

Neurological manifestations related to electrolyte disorders, drug toxicity, and uremia are common in chronic kidney disease (CKD). Seizures and coma are frequent complications of acute renal insufficiency (uremia), whereas peripheral neuropathy and encephalopathy, observed in progressive uremia, are terminal events. Failure to excrete metabolic products causes their accumulation and can lead to severe intoxication. Read More

J Clin Diagn Res 2017 Jun 1;11(6):OC37-OC40. Epub 2017 Jun 1.

Professor, Department of Nephrology, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey.

Introduction: Uremic polyneuropathy is very common among patients with Chronic Kidney Disease (CKD). The patients have electrophysiologic signs of impaired nerve function, although a lower percentage of patients are symptomatic. Electrophysiological parameters are quantitative indices of Polyneuropathy (PNP) severity. Read More

Heart Views 2017 Apr-Jun;18(2):62-63

Department of Cardiology, JLN Hospital, Ajmer, Rajasthan, India.

A 55-year-old diabetic woman suffered a posterior wall ST-elevation myocardial infarction. She developed contrast-induced nephropathy following coronary angiography. Acute fulminant uremic neuropathy was precipitated which initially mimicked Guillan-Barre Syndrome, hence reported. Read More

Postepy Hig Med Dosw (Online) 2017 Jan 22;71(0):32-39. Epub 2017 Jan 22.

Uniwersyteckie Centrum Okulistyki i Onkologii Samodzielnego Publicznego Szpitala Klinicznego Śląskiego Uniwersytetu Medycznego w Katowicach; Klinika Okulistyki Katedry Okulistyki, Wydział Lekarski w Katowicach Śląskiego Uniwersytetu Medycznego w Katowicach.

Chronic renal failure is associated with many neurological complications. Due to accumulation of uremic neurotoxins axonal degeneration with its secondary demyelination occurs, which results in development of polineuropathy in 60‑100% of patients with chronic renal failure. One of the most severe peripheral neuropathy is optic neuropathy. Read More

J Adv Res 2017 Mar 2;8(2):99-111. Epub 2016 Dec 2.

Rheumatology and Clinical Immunology Unit, Department of Internal Medicine, Cairo University, Egypt.

Vasculitis is a remarkable presentation of the extrahepatic manifestations of HCV. According to the presence or absence of cryoglobulins it is subdivided into two main types: cryoglobulinemic vasculitis and non cryoglobulinemic vasculitis based on the attribution of vasculitis to serum cryoglobulins as a pathogenic factor. The attribution of cryoglobulinemia to HCV represents a success story in the history of immunology, microbiology, and clinical medicine. Read More

Clin Nephrol 2017 Mar;87 (2017)(3):134-139

Objectives: This study seeks to examine the characteristics and health-related quality of life (HRQL) of patients with uremic peripheral neuropathy.

Methods: Uremic patients undergoing maintenance hemodialysis (MHD) at our hospital were enrolled in this study. Data collection began in January 2011 and ended in June 2011. Read More

Hemodial Int 2017 01 11;21(1):63-71. Epub 2016 Jul 11.

Biostatistics Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

Introduction: Pruritus is one of the frustrating skin manifestations of advanced renal failure. Many options have been used for the management of uremic pruritus (UP) such as pregabalin. There are some studies that reported beneficial effects of pregabalin in reducing UP; however, most of them did not have a comparator arm. Read More

Expert Rev Neurother 2016 11 7;16(11):1263-1277. Epub 2016 Jul 7.

a Instituto de Neurociencias y Centro de Investigación Biomédica, Universidad de Granada , Granada , Spain.

Introduction: The first two alphadelta ligands - gabapentin (GBP) and pregabalin (PGB) - were initially synthesized as antiepileptics; however, they were later also found to be useful for the treatment of additional conditions. Areas covered: Relevant publications describing potential underlying mechanisms, clinical pharmacokinetics/pharmacokinetics, and clinical efficacy and safety of these drugs in various disease conditions were searched in PubMed and Scopus and included in this review. Expert commentary: GBP and PGB are effective for the treatment neuropathic pain, fibromyalgia and epilepsy; in addition, they may be useful for the reduction of postoperative pain. Read More

BMC Nephrol 2015 Aug 12;16:134. Epub 2015 Aug 12.

Department of Internal Medicine, Division of Nephrology, University Health Network Toronto General Hospital, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada.

Background: Uremic neuropathy is a common complication in patients with end stage kidney disease. Its pathogenesis has been attributed to accumulation of uremic toxins. Kidney transplantation has been the best therapeutic option. Read More