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Front Pharmacol 2022 27;13:873150. Epub 2022 Apr 27.

Department of Pharmacology, School of Pharmacy and Minhang Hospital, Fudan University, Shanghai, China.

Long-term peritoneal dialysis (PD) causes intestinal dysfunction, including constipation, diarrhea, or enteric peritonitis. However, the etiology and pathogenesis of these complications are still unclear and there are no specific drugs available in the clinic. This study aims to determine whether Astragaloside IV (AS IV) has therapeutic value on PD-induced intestinal epithelial barrier dysfunction and . Read More

Exp Clin Transplant 2022 May;20(Suppl 3):45-48

From the Department of Pediatric Nephrology, Dr. Sami Ulus Maternity and Child Health and Diseases Training and Research Hospital, Ankara, Turkey.

Membranoproliferative glomerulonephritis and renal microangiopathies may manifest similar clinical presentations and histology. Many genetic mutations that cause these diseases have been reported. Studies on mutations in the gene encoding diacylglycerol kinase epsilon identified a novel pathophysiologic mechanism leading to atypical hemolytic uremic syndrome and/or membranoproliferative glomerulonephritis. Read More

Blood Cells Mol Dis 2022 May 7;96:102666. Epub 2022 May 7.

Department of Medical Laboratory Science and Technology, Harbin Medical University-Daqing, Daqing, China. Electronic address:

The link between hyperuricemia (HUA) and the risk of venous thromboembolism (VTE) has been well established. However, the mechanisms of thrombus generation and the effect of HUA on procoagulant activity (PCA) of erythrocytes remain unclear no matter in uremia or hyperuricemia. Here, phosphatidylserine (PS) exposure, microparticles (MPs) release, cytosolic Ca, TMEM16F expression, reactive oxygen species (ROS) and lipid peroxidation of erythrocyte were detected by flow cytometer. Read More

Parasit Vectors 2022 May 10;15(1):147. Epub 2022 May 10.

The Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, P. O. Box 12, 761001, Rehovot, Israel.

Background: Three species of Leishmania cause disease in humans in Israel and are endemic in the Middle East: Leishmania infantum, Leishmania tropica and Leishmania major. These species infect dogs and cats, but little is known about their prevalence in pet populations and their clinical manifestations. A study on dog and cat Leishmania infection was conducted in a focus of human L. Read More

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1388-1396

Department of Nephrology, Dialysis and Transplantation, Charles Nicolle Hospital; Faculty of Medicine of Tunis, University of Tunis El Manar, Tunis, Tunisia.

The elderly population has significantly increased in the world. Nephrotic syndrome (NS) is one manifestation of glomerular nephropathy in the elderly. The objective of our study is to determine NS particularities in the elderly and to identify the factors predicting progression to chronic end-stage renal disease (ESRD). Read More

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1264-1272

Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Medical Sciences (Deemed to be University), Sawangi (Meghe), Wardha, Maharashtra, India.

We aimed to study the correlation of measurable uremic toxins with electrophysiological parameters of uremic polyneuropathy in chronic kidney disease (CKD) patients. This study was conducted between January 2018 and December 2018, 40 CKD patients on hemodialysis (HD) and 40 controls were included in the present study. Prevalence of peripheral neuropathy in CKD patients was 50% clinically and 65% of patients found to have neuropathy by electrophysiological study. Read More

Ann Transl Med 2022 Apr;10(7):395

Institute of Medical Technology, Peking University Health Science Center, Beijing, China.

Background: Community-acquired pneumonia (CAP) is often accompanied by changes in lipid metabolism. This study aimed to examine the changes in serum phospholipids (PLs) that may be useful for early disease stratification and as potential therapeutic targets in patients with CAP.

Methods: Serum samples from 58 patients hospitalized with CAP and 11 control samples were collected during admission between January 2017 and October 2018. Read More

Turk J Emerg Med 2022 Apr-Jun;22(2):114-117. Epub 2022 Apr 11.

Department of Emergency and Trauma, Hospital Sungai Buloh, Jalan Hospital, Petaling, Selangor, Malaysia.

Rectus sheath hematoma (RSH) is a life-threatening condition. Its pathology lies behind its unique anatomy. Critically ill COVID-19 patients are managed in the emergency department for longer periods while awaiting critical care admission. Read More

Front Endocrinol (Lausanne) 2022 22;13:869899. Epub 2022 Apr 22.

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, Hong Kong SAR, China.

In developed countries, diabetes is the leading cause of chronic kidney disease (CKD) and accounts for 50% of incidence of end stage kidney disease. Despite declining prevalence of micro- and macrovascular complications, there are rising trends in renal replacement therapy in diabetes. Optimal glycemic control may reduce risk of progression of CKD and related death. Read More

Kidney Dis (Basel) 2022 Mar 14;8(2):103-114. Epub 2022 Jan 14.

Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, United Kingdom.

Background: Erythropoietin-stimulating agent (ESA) hyporesponsiveness is commonly observed in patients with anemia secondary to chronic kidney disease (CKD). Because of its complexity, a global consensus on how we should define ESA hyporesponsiveness remains unavailable. The reported prevalence and demographic information on ESA hyporesponsiveness within the CKD population are variable with no consensus definition. Read More

Ann Palliat Med 2022 Apr;11(4):1431-1440

Department of Nephrology, Yan'an Hospital of Kunming City, Kunming, China.

Background: Uremia is a clinical syndrome caused by the development of chronic renal failure to the end-stage. Corbrin Capsule has the effect of tonifying the lungs and kidneys and improving the essence and qi, which can improve the metabolic disorders of the body. However, there is currently no systematic evaluation of the efficacy of Corbrin Capsule in the treatment of uremia malnutrition, inflammation, and atherosclerosis (MIA) syndrome. Read More

Cureus 2022 Mar 31;14(3):e23681. Epub 2022 Mar 31.

Department of Surgery, Beaumont Health, Farmington Hills, USA.

Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is in and of itself a rare entity and is a subset of the Epstein-Barr virus (EBV)-associated lymphoma. Due to its indolent course, FA-DLBCL is generally an incidental finding on histopathological examinations. We present the first reported case of FA-DLBCL found within a native aortic thrombus during an aorto-biiliac bypass. Read More

Eur Rev Med Pharmacol Sci 2022 Apr;26(8):3010-3024

School of Pharmacy, Nanjing Tech University, Nanjing, China.

Objective: The aim of the study was to improve the bioavailability of Cinacalcet hydrochloride (CLC) and enhance its efficacy by the nanoemulsion drug delivery system.

Materials And Methods: First, cinacalcet hydrochloride-nanoemulsion (CLC-NE) was prepared and optimized through the pseudo ternary phase diagram and central composite design response surface methodology (CCD). The release of CLC-NE in vitro was investigated with four different dissolution media, and the bioavailability of CLC-NE in vivo was studied through beagle dogs. Read More

Indian J Hematol Blood Transfus 2022 Apr 3;38(2):359-365. Epub 2021 Jul 3.

Nephrology Unit, Colombo South Teaching Hospital, Kalubowila, Sri Lanka.

Diagnosing iron deficiency with currently available tests is difficult in patients with chronic kidney disease (CKD) due to the inflammatory state associated with uraemia. The aim of this study was to evaluate the importance of reticulocyte haemoglobin (CHr) as a diagnostic tool of iron deficiency and a predictor to intravenous iron therapy in a cohort of CKD patients on haemodialysis in Sri Lanka. This was a descriptive cross sectional study involving hundred (100) patients with CKD on regular haemodialysis and erythropoietin. Read More

Cureus 2022 Mar 28;14(3):e23577. Epub 2022 Mar 28.

Hematology and Oncology, Great Falls Clinic, Great Falls, USA.

Atypical hemolytic uremic syndrome (aHUS) occurs in patients with defective alternative complement pathways, making them susceptible to thrombotic microangiopathy (thrombocytopenia, intravascular hemolysis, and renal failure), and is usually triggered by infectious agents. Influenza and Streptococcus pneumonia are known triggers for aHUS. However, influenza vaccination triggering aHUS is rarely reported. Read More

Front Immunol 2022 12;13:860689. Epub 2022 Apr 12.

Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, Paris, France.

As part of the innate immune system, the complement system plays a key role in defense against pathogens and in host cell homeostasis. This enzymatic cascade is rapidly triggered in the presence of activating surfaces. Physiologically, it is tightly regulated on host cells to avoid uncontrolled activation and self-damage. Read More

Front Med (Lausanne) 2022 13;9:850966. Epub 2022 Apr 13.

Dialysis Department of Nephrology Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

Introduction: Increasing evidence supports the idea that the disruption of epithelial tight junction proteins (TJPs) caused by accumulation of uremia toxins, such as homocysteine (Hcy), is one of the most important mechanisms underlying the damage of intestinal barrier function (IBF) in chronic kidney disease (CKD). Since the decrease of hypoxia inducible factor-1α (HIF-1α) is reported to be involved in Hcy-induced cell injury, and the upregulation of microRNA-223 (miR-223) plays a vital protective role in the impairment of IBF in the experimental colitis, we investigated the effect of HIF-1α stabilizer roxadustat on the disruption of TJPs induced by Hcy and CKD and the underlying mechanism.

Methods: Chronic kidney disease was induced in rats 5/6 nephrectomy. Read More

Tissue Cell 2022 Apr 15;76:101799. Epub 2022 Apr 15.

Histology and Cell Biology Department, Faculty of Medicine, Menoufia University, Egypt.

Background: Gum Arabic (GA) has a protective role against experimental nephrotoxicity and hepatotoxicity. This study explores the possible ameliorating effect of Gum Arabic on the liver tissues of the uremic rats.

Materials & Methods: 50 adult male albino rats were divided into 5 groups; Group I, (negative control). Read More

Crit Care 2022 04 28;26(1):116. Epub 2022 Apr 28.

Department of Medicine, Veterans Affairs Medical Center, 3550 La Jolla Village Drive, San Diego, CA, USA.

Preclinical models of acute kidney injury (AKI) consistently demonstrate that a uremic milieu enhances renal recovery and decreases kidney fibrosis. Similarly, significant decreases in monocyte/macrophage infiltration, complement levels, and other markers of inflammation in the injured kidney are observed across multiple studies and species. In essence, decreased renal clearance has the surprising and counterintuitive effect of being an effective treatment for AKI. Read More

Kidney Int 2022 05;101(5):1092

Department of Nephrology, Hypertension and Kidney Transplantation, Medical University of Lodz, Lodz, Poland. Electronic address:

J Invest Surg 2022 Apr 21:1-10. Epub 2022 Apr 21.

Department of Plastic, Reconstructive and Aesthetic Surgery, Baskent University, Ankara, Turkey.

Background: The presence of chronic renal disease(CRD) concurrently with diabetes mellitus(DM) increases the flap failure. Adipose derived stromal vascular fraction (SVF) is known to enhance skin flap viability in both healthy and diabetic individuals. The aim of this experimental study was to investigate the effect of SVF on skin flap viability in rats with DM and CRD. Read More

Toxins (Basel) 2022 Apr 14;14(4). Epub 2022 Apr 14.

Nephrology Department, Ambroise Paré University Hospital, APHP, F-92100 Paris, France.

Patients with chronic kidney disease (CKD) have an elevated prevalence of atheromatous (ATH) and/or non-atheromatous (non-ATH) cardiovascular disease (CVD) due to an array of CKD-related risk factors, such as uremic toxins (UTs). Indeed, UTs have a major role in the emergence of a spectrum of CVDs, which constitute the leading cause of death in patients with end-stage renal disease. The European Uremic Toxin Work Group has identified over 100 UTs, more than 25 of which are dietary or gut-derived. Read More

Toxins (Basel) 2022 Apr 12;14(4). Epub 2022 Apr 12.

Nephrology Division, NYU Langone Medical Center, New York, NY 10016, USA.

Indoxyl sulfate, closely related to indigo, a dye valued for it binding to cloth, has been recognized as a protein-bound solute bound to albumin, present in increased concentration in the serum of patients with impaired glomerular filtration (13). The early studies of Niwa identified indoxyl sulfate as a toxin capable of accelerating the rate of renal damage in subtotal nephrectomized rats (18). Over the past decade other protein-bound solutes have been identified in the plasma of patients with impaired glomerular filtration. Read More

J Assoc Physicians India 2022 Apr;70(4):11-12

DY Patil Hospital, Kolhapur.

Type 2 diabetes mellitus is the leading cause of end stage renal disease. Chronic kidney disease (CKD) especially end stage renal disease (ESRD) usually require renal replacement therapy and are on maintenance dialysis. Glycemic control is challenging in ESRD because of uremia. Read More

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2022 Mar;30(2):207-210

N. A. Semashko National Research Institute of Public Health, 105064, Moscow, Russia.

Lately, in case of a number of life-threatening and chronic progressive rare (orphan) diseases, resulting in decreasing of life expectancy of citizens or their disability, the powers to support patients with medications were transferred from regional to federal level. Among these diseases are hemolytic uremic syndrome, mucopolysaccharidose type I, II, VI, juvenile arthritis with systemic onset, unspecified aplastic anemia, hereditary deficiency of factors II (fibrinogen), VII (labile), X (Stuart-Prauer). The article considers data concerning hemolytic uremic syndrome, mucopolysaccharidosis type I, II, VI, juvenile arthritis with systemic onset - the diseases for which medication support provision was transferred to Federal level in the first place and for which at the time of preparation of the article there were sufficient data to analyze. Read More

J Nephrol 2022 Apr 16. Epub 2022 Apr 16.

Division of Nephrology, Hypertension, and Kidney Transplantation, University of California Irvine School of Medicine, 101 The City Drive South, City Tower, Orange, CA, 92868, USA.

Background: Dialysis patients experience a high symptom burden, which may adversely impact their quality of life. Whereas other specialties emphasize routine symptom assessment, symptom burden is not well-characterized in dialysis patients. We sought to examine the prevalence and severity of unpleasant symptoms in a prospective hemodialysis cohort. Read More

Br J Pharmacol 2022 Apr 15. Epub 2022 Apr 15.

Division of Nephrology and Rheumatology, Shanghai Tenth People's Hospital, Shanghai, China.

Background And Purpose: Chronic kidney disease (CKD) is a global public health problem and one of the leading causes of all-cause mortality. However, the pathogenic mechanisms and intervention methods for CKD progression are not fully understood.

Experimental Approach: Plasma from patients with uraemia and from healthy controls (n = 30 per group) was analysed with LC-MS/MS-based non-targeted metabolomics to identify potential markers of uraemia. Read More

Pediatr Infect Dis J 2022 05;41(5):e255

Department of Paediatrics and Adolescent Medicine, The Hong Kong Children's Hospital, Hong Kong SAR, China.

J Vet Diagn Invest 2022 May 12;34(3):496-503. Epub 2022 Apr 12.

Alberta Veterinary Laboratories, Calgary, AB, Canada.

We evaluated a saliva urea test strip (Kidney-Chek; SN Biomedical), as a rapid, noninvasive method to screen for azotemia. The test is a semiquantitative method that assesses 7 levels of saliva urea concentration, and indirectly serum urea, from <3 to >17 mmol/L. Ninety-two dogs (14 azotemic) with serum urea of 1. Read More

Hemodial Int 2022 Apr 11. Epub 2022 Apr 11.

Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.

Background And Objectives: The immunogenicity of vaccines is known to be attenuated in patients with end-stage kidney disease due to uremia. Patients on dialysis were excluded from coronavirus disease 2019 (COVID-19) vaccine trials; thus, the effectiveness of vaccines for this population is unclear. The aim of this study was to explore whether Asian dialysis patients can effectively produce an immune response after being vaccinated with the first dose of the ChAdOx1 nCoV-19 vaccine. Read More