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Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

Nanotechnology Research Center, Uremia University, Uremia, Iran.

Growth factors are necessary for proper and efficient wound closure and tissue regeneration. Epidermal growth factor (EGF) is one of the key signaling molecules in stimulating epithelial cell motility, making it a required factor for re-epithelialization. Increased EGF expression is likely to be a strong prognostic and predictive feature in multiple tumor types and determination of EGF may product remarkable diagnosis benefits. Read More

J Food Drug Anal 2019 Apr 28;27(2):542-550. Epub 2018 Oct 28.

Proteomics Core Laboratory, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. Electronic address:

High-density lipoprotein (HDL) carbamylation has been known in uremia patients. Paraoxonase-1 (PON-1) is an important HDL protein responsible for HDL anti-oxidant, arylesterase and lactonase activities. PON-1 carbamylation in uremic HDL has never been explored. Read More

G Ital Nefrol 2019 Apr;36(2)

UOC di Nefrologia e Dialisi, P.O. "San Giovanni di Dio", Agrigento, Italia.

Native arteriovenous fistula is the preferred vascular access because of it does not usually cause infections and seems to be closely related with prolonged patient survival, compared to prosthetic grafts and central venous catheters; it also is cost effective. Venous stenosis is one of the main causes of AVF failure. It is caused by a number of upstream and downstream events. Read More

Sci Rep 2019 Apr 10;9(1):5871. Epub 2019 Apr 10.

Dalian Medical University Graduate School, Dalian, China.

In order to develop an equation that integrates multiple clinical factors including signs and symptoms associated with uraemia to assess the initiation of dialysis, we conducted a retrospective cohort study including 25 haemodialysis centres in Mainland China. Patients with ESRD (n = 1281) who commenced haemodialysis from 2008 to 2011 were enrolled in the development cohort, whereas 504 patients who began haemodialysis between 2012 and 2013 were enrolled in the validation cohort comprised. An artificial neural network model was used to select variables, and a fuzzy neural network model was then constructed using factors affecting haemodialysis initiation as input variables and 3-year survival as the output variable. Read More

Kidney Blood Press Res 2019 Apr 8:1-9. Epub 2019 Apr 8.

Department of Pathophysiology, Poznan University of Medical Sciences, Poznan, Poland,

Background/aims: Thromboembolic episodes are a frequent problem in end stage renal failure patients. The pathomechanism of the disorder is complex, including bioincompatibility of renal replacement therapy, endothelial dysfunction, increased blood level of procoagulant factors and uremic toxins. We studied changes in the functional properties of venous endothelial cells (VEC) in the presence of uremic serum and evaluated their possible modulation by N-acetylcysteine (NAC) or sulodexide (SUL). Read More

Curr Drug Metab 2019 Apr 2. Epub 2019 Apr 2.

Molecular Pharmacotherapeutics, Faculty of Pharmacy, Kanazawa University, Kakuma-machi, Kanazawa 9201192. Japan.

Background: Evidence has revealed that renal impairment can affect the systemic exposure of drugs which are predominantly eliminated via the liver. The modulation of drug-metabolizing enzymes and transporters expressed in the liver and/or small intestine by diverse entities, including uremic toxins, in systemic circulation of patients with severe renal failure is considered as the cause of atypical pharmacokinetics, which sometimes induce undesirable adverse events that are especially critical for drugs with narrow therapeutic window such as anticancer drugs. A dosing strategy for anticancer drugs in these patients need to be established. Read More

PLoS One 2019 4;14(4):e0214808. Epub 2019 Apr 4.

Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan.

Workers processing nephrite, antigorite, or talc may be exposed to paragenetic asbestos minerals. An effective screening method for pneumoconiosis in workers exposed to asbestos-contaminated minerals is still lacking. The objective of this study was to assess the diagnostic accuracy of serum and urinary biomarkers for pneumoconiosis in workers exposed to asbestos-contaminated minerals. Read More

Mater Sociomed 2018 Dec;30(4):246-250

Departmant for Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Introduction: An increase in nitric oxide (NO) synthesis concentration could help alleviate some pathological changes directly related to uremia.

Aim: To investigate the concentration of nitric oxide in saliva of patients with terminal stage of chronic renal failure on hemodialysis and to investigate the effect of hemodialysis on concentration of nitric oxide in saliva of the patients with terminal stage of chronic renal failure on hemodialysis.

Material And Methods: The study had a prospective character and included 60 respondents of both sexes, at age between 20 and 60 years. Read More

Zhonghua Er Ke Za Zhi 2019 Apr;57(4):286-290

Department of Nephrology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.

To summarize the clinical data and molecular characteristics of two siblings with Fechtner syndrome. A retrospective analysis was made on the clinical data, laboratory tests and genetic test results of two siblings with Fechtner syndrome in a family who were followed up in the Department of Nephrology, Children's Hospital Affiliated to Nanjing Medical University from April 2018 to August 2018. Both siblings showed proteinuria, microscopic hematuria and thrombocytopenia. Read More

Am J Kidney Dis 2019 Mar 28. Epub 2019 Mar 28.

Singapore Eye Research Institute, Singapore National Eye Centre; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore; Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School. Electronic address:

Eyes and kidneys have numerous structural, developmental, physiologic, and pathogenic pathways in common, suggesting that many kidney and eye diseases may be interlinked. Studies suggest that the prevalence of eye diseases and vision impairment are higher among persons with end-stage kidney disease and earlier stages of chronic kidney disease (CKD) than in those without. Ocular morbidity in persons with CKD and end-stage kidney disease may be due to the following risk factors: (1) underlying conditions and risk factors for CKD such as diabetes or hypertension, (2) metabolic disorders associated with CKD, (3) uremia and anemia, and (4) CKD treatment. Read More

J Vet Intern Med 2019 Mar 30. Epub 2019 Mar 30.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California.

Introduction: Acute kidney injury (AKI) leading to severe uremia is associated with high morbidity and mortality. Mannitol is an osmotic diuretic, widely used in the management of AKI, both as a bolus injection and as a constant rate infusion (CRI).

Objectives: To determine the plasma concentration of mannitol after a bolus injection and CRI at the recommended dosages, and to assess the effect of mannitol on renal function variables including urine production, glomerular filtration rate (GFR), and solute excretion. Read More

J Med Syst 2019 Mar 29;43(5):129. Epub 2019 Mar 29.

Department of Nephrology, The Affiliated Hospital of Jining Medical University, No.89 Guhuai Road, Jining, Shandong, 272000, People's Republic of China.

To analyze the longitudinal peak systolic strain of left ventricular myocardium in three layers before and after hemodialysis in uremic patients, and to explore the value of eSie VVI (Velocity Vector Imaging) technology in evaluating the changes of left ventricular myocardial systolic function in uremic patients in a short time after hemodialysis, the longitudinal peak systolic laminar strain and global full-thickness strain of 17 segments of the left ventricle are obtained by eSie VVI software analysis, and the results are deduced in Excel form. Statistical analysis is made on the results of longitudinal peak systolic stratified strain of left ventricular inner, middle and outer layers and whole myocardium in uremic patients before and after hemodialysis. The results show that eSie VVI technology can more sensitively and accurately evaluate the changes of left ventricular myocardial systolic function after hemodialysis in uremic patients, and has certain clinical value. Read More

Sci Rep 2019 Mar 25;9(1):5041. Epub 2019 Mar 25.

Department of Pathophysiology, Faculty of Medicine, Medical University of Gdańsk, Gdańsk, Poland.

At the moment it is unknown to what extent the impaired function of T lymphocytes in ESRD patients depends on uremia, and to what extent on hemodialysis (HD) procedure. Therefore, the purpose of the study was to evaluate percentages of T lymphocyte subpopulations ex vivo, plasma concentrations of IL12p70, TNF, IL-10, IL-6, IL-1β, IL-8 cytokines and selected proliferation parameters of in vitro activated T lymphocytes in HD patients before and after single HD procedure using flow cytometry. We demonstrated that the percentage of CD8 cells ex vivo was decreased while the CD4/CD8 ratio was increased after HD procedure. Read More

Semin Dial 2019 Mar 24. Epub 2019 Mar 24.

John Walls Renal Unit, University Hospitals Leicester NHS Trust, Leicester, UK.

Patients on hemodialysis are physically inactive. Less than 50% of hemodialysis patients undertake exercise once a week and such patients have increased mortality compared to patients who undertake regular exercise. The reasons for physical inactivity and reduced functional capacity are complex and inter-related, with skeletal muscle catabolism, chronic inflammation, anemia, malnutrition, uremia, the burden of co-morbid diseases, and "enforced" sedentary time during hemodialysis all contributing. Read More

Prog Mol Biol Transl Sci 2019 21;162:377-390. Epub 2019 Feb 21.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

The prostate-specific antigen (PSA), a glycoprotein, is a clinically used biomarker for screen and diagnosis of prostate cancer. Most of PSA in blood circulation is protein-bound, and only a small fraction is present as free PSA. In general, the serum total PSA levels are <4ng/mL in healthy controls and significantly increased in certain prostate cancer patients. Read More

Prog Mol Biol Transl Sci 2019 6;162:363-376. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Bilirubin is produced by the breakdown of hemoglobin in senescent erythrocytes by macrophages and carried by albumin from blood circulation to the liver for removal in normal physiology. Glucuronic acid modification of bilirubin by UDP-glucuronyltransferase in the liver is the key event for its subsequent elimination from human body. Conditions that accelerate the breakdown of erythrocytes may cause an elevated blood level of unconjugated bilirubin whereas the factors affect the glucuronidated bilirubin formation and subsequent elimination may cause decreased or increased blood level of glucuronidated bilirubin, the water soluble "direct bilirubin" measured by clinical blood test. Read More

Prog Mol Biol Transl Sci 2019 8;162:349-362. Epub 2019 Mar 8.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Fucosylated glycans are essential molecules that facilitate signal transductions in several signal pathways and play important roles in development, inflammation, infection, and tumor metastasis. The fucosylated glycans are difficult to be developed into clinical biomarkers due to their complicated structures, but the decreased or increased activities of serum α-l-fucosidase, the lysosomal enzyme required for fucosylated glycan degradation, are diagnostic biomarker for patients with fucosidosis and hepatocellular carcinoma, respectively. However, the relationship between serum α-l-fucosidase activities and other human diseases is largely unknown. Read More

Prog Mol Biol Transl Sci 2019 6;162:307-319. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Serum glycated albumin (GA) level is used along with that of glucose and glycated hemoglobin (HbA1c) as indicators of glycemic control for diabetic patients. Although serum GA levels are affected by blood glucose level, they are also influenced by serum albumin metabolism and other pathological conditions. However, a systematic comparison of the serum GA levels in different types of human diseases has not been reported. Read More

Prog Mol Biol Transl Sci 2019 6;162:293-306. Epub 2019 Mar 6.

Institute of Cerebrovascular Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

HbA1c is a glycated hemoglobin. The ≥6.5% HbA1c in total hemoglobins has been used in diagnosing and guiding therapy for patients with diabetes since 1970s. Read More

Prog Mol Biol Transl Sci 2019 6;162:265-276. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

CA153 was originally discovered as a tumor antigen recognized by two monoclonal antibodies DF3 and 115D8 simultaneously. Subsequent studies showed that DF3 recognizes the core protein of mucin1 (MUC1 or CD227) whereas 115D8 recognizes part of the glycan chains on MUC1. MUC1 is a highly glycosylated transmembrane protein expressed on the mucosal surfaces of epithelial cells in lung, breast, stomach, gallbladder, lymph node, colon, rectum, and pancreas. Read More

Prog Mol Biol Transl Sci 2019 6;162:213-227. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Carcinoembryonic antigen (CEA) was first identified as colon cancer antigen in 1965. The higher serum CEA level than that of healthy individuals led to its clinical application as a diagnostic biomarker for colorectal cancer. Subsequent molecular biology studies revealed that CEA are glycoproteins from a family of 32 genes and are normally expressed in various tissues. Read More

Prog Mol Biol Transl Sci 2019 9;162:165-175. Epub 2019 Mar 9.

Systems Biology and Medicine Center for Complex Diseases, Affiliated Hospital of Qingdao University, Qingdao, China. Electronic address:

Increased serum squamous cell carcinoma antigen (SCCA) levels are clinically used diagnostic or prognostic biomarker for squamous cell carcinomas. According to recently published studies, increased serum SCCA levels are also observed in adenocarcinomas, hepatocarcinomas, kidney, and other inflammatory diseases, indicating squamous cell carcinoma is not the production source of serum SCCA in these diseases. However, serum SCCA levels in patients suffering different types of diseases have not been systematically measured and compared. Read More

Prog Mol Biol Transl Sci 2019 6;162:141-163. Epub 2019 Mar 6.

Systems Biology and Medicine Center for Complex Diseases, Ocean University of China, Qingdao, China. Electronic address:

Most of clinically used cancer biomarkers are either specific glycan structures or glycoproteins. Although the high serum levels of the cancer biomarkers are also present in certain patients suffering noncancer diseases, systematic measurement and comparison of the serum levels of all cancer biomarkers among cancer and noncancer patients have not been reported. In this study, the serum levels of 17 glucose and glycan-related biomarkers including 10 cancer biomarkers SCCA, CA724, CA50, CA242, CA125, CA199, CA153, AFP, CEA, and PSA were retrospectively investigated based on clinical laboratory data in two medical centers during the past 6 years (2012-2018). Read More

Int J Biol Macromol 2019 Mar 20;131:697-705. Epub 2019 Mar 20.

Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India. Electronic address:

In chronic kidney diseases (CKD), uremic toxins accumulate in the blood plasma of patients and interact with human serum albumin (HSA) and thus impaired its role as carrier protein. Present study shows in vitro effect of carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), indoxyl sulfate (IS), indole-3 acetic acid (IAA), and hippuric acid (HA) with human serum albumin (HSA) at pathological concentrations. HSA bind with CMPF, IS and IAA at both of its binding sites with high affinity (order of 10 to 10 M) and low affinity (order of 10 to 10 M). Read More

Biosci Rep 2019 Apr 12;39(4). Epub 2019 Apr 12.

Department of Postgraduate Medicine, Hertfordshire, University of Hertfordshire, U.K.

Introduction: The gastrointestinal tract is a potential source of inflammation in dialysis patients. studies suggest breakdown of the gut barrier in uraemia leading to increased intestinal permeability and it is hypothesised that haemodialysis exacerbates this problem due to mesenteric ischaemia induced by blood volume changes during treatment.

Method: The effect of haemodialysis on intestinal permeability was studied in ten haemodialysis patients and compared with five controls. Read More

Nephrol Dial Transplant 2019 Mar 20. Epub 2019 Mar 20.

Department of Nephrology and Rheumatology, Aichi Medical University, Nagakute, Japan.

Background: High peritoneal transport is associated with high mortality and technical failure in peritoneal dialysis (PD). Baseline peritoneal solute transport rate (PSTR) as measured by the peritoneal equilibration test (PET) within 6 months after PD initiation varies between patients. Sodium is reported to be stored in the skin or muscle of dialysis patients. Read More

Rev Assoc Med Bras (1992) 2019 Feb;65(2):281-286

Department of Integrated Clinical Discussions, ABC Medical School, Av. Príncipe de Gales, 821, CEP 09060-650, Santo André, SP, Brasil.

Introduction: Peripheral neuropathy is a disorder that affects the cell body, axon or myelin of motor or peripheral sensory neurons and occurs in 60-100% of patients who are submitted to dialysis due to chronic kidney disease. Uremic neuropathy is attributed to the accumulation of organic waste, evident in patients with reduced glomerular filtration rate.

Objectives: This review aims to make clinical characteristics of uremic neuropathy evident enabling early diagnosis and treatment. Read More

Curr Pharm Des 2019 Mar 18. Epub 2019 Mar 18.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047. China.

Iron deficiency, one of the most common nutritional deficient disorders, frequently affects infants, adolescents and pregnant women and impairs growth, development and immune responses. Iron deficiency may also be secondary to gastrointestinal conditions such as gastrectomy and inflammatory bowel disease, as well as cancer and chronic uremia. Iron supplementation is the most commonly selected treatment option for iron deficiency. Read More

Probiotics Antimicrob Proteins 2019 Mar 16. Epub 2019 Mar 16.

Department of Pharmacology, SSR College of Pharmacy, Silvassa, U. T. of Dadra Nagar & Haveli, 396230, India.

To screen Bacillus clausii UBBC07 as a putative probiotic strain and to examine the protective effect of probiotic-B. clausii UBBC07 spore on uremia on rats induced by acetaminophen. In vitro tests performed to screen potential probiotic strains were gastric and bile acid resistance and ability to reduce pathogen adhesion to surfaces. Read More

Kidney Int 2019 May 12;95(5):1064-1078. Epub 2019 Mar 12.

Maimonides Institute for Biomedical Research (IMIBIC), Cordoba, Spain; Nephrology Service, Reina Sofia University Hospital, Cordoba, Spain; University of Cordoba, Cordoba, Spain; Spanish Renal Research Network (REDinREN), Institute of Health Carlos III, Madrid, Spain.

Calcimimetics decrease parathyroid hormone (PTH) secretion in patients with secondary hyperparathyroidism. The decrease in PTH should cause a reduction in bone turnover; however, the direct effect of calcimimetics on bone cells, which express the calcium-sensing receptor (CaSR), has not been defined. In this study, we evaluated the direct bone effects of CaSR activation by a calcimimetic (AMG 641) in vitro and in vivo. Read More

Adv Chronic Kidney Dis 2019 Jan;26(1):8-15

Texas A&M Health Science Center College of Medicine, Scott & White Medical Center-Temple, Temple, TX. Electronic address:

Cardiovascular disease and infections are directly or indirectly associated with an altered immune response, which leads to a high incidence of morbidity and mortality, and together, they account for up to 70% of all deaths among patients with chronic kidney dysfunction. Impairment of the normal reaction of the innate and adaptive immune systems in chronic kidney disease predisposes patients to an increased risk of infections, virus-associated cancers, and a diminished vaccine response. On the other hand, an abnormal, exaggerated reaction of the immune systems can also occur in this group of patients, resulting in increased production and decreased clearance of proinflammatory cytokines, which can lead to inflammation and its sequelae (eg, atherosclerotic cardiovascular disease). Read More

Biosens Bioelectron 2019 May 4;132:122-131. Epub 2019 Mar 4.

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

Functionalized fibrous nano-silica (KCC-1) was applied to specific electrochemical detection of HT 29 colorectal cancer cells based on folate (FA)/folate receptor (FR) interactions. KCC-1 fibrous materials were synthesized using a hydrothermal method and then functionalized with FA molecules to produce KCC-1-NH-FA nanoparticles. The KCC-1-NH-FA fibrous nanoparticles offer favorable bleaching stability and exceptional surface area-to-volume ratio which provide facility to design more sensitive cytosensors. Read More

Cureus 2019 Jan 4;11(1):e3826. Epub 2019 Jan 4.

Nephrology, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA.

Uremic gastroenteropathy is a well-accepted but less often described sequelae of an underlying renal disease. With the advent of modern dialysis treatments, rarer manifestations, such as pancolitis, may go overlooked in the evaluation, pursuing more common diagnoses. The underlying pathophysiology of uremic gastroenteropathy is not completely understood; however, several underlying mechanisms have been identified to play a role. Read More

Nat Commun 2019 03 13;10(1):1203. Epub 2019 Mar 13.

Clinical Center for Human Genomic Research, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.

Vascular calcification is highly prevalent in end-stage renal diseases and is predictive of cardiovascular events and mortality. Poly(ADP-ribose) polymerase 1 (PARP1) inhibition or deletion is vasoprotective in several disease models. Here we show that PARP activity is increased in radial artery samples from patients with chronic renal failure, in arteries from uraemic rats, and in calcified vascular smooth muscle cells (VSMCs) in vitro. Read More

J Drug Assess 2019 6;8(1):21-24. Epub 2019 Feb 6.

Department of Emergency Medicine, Mackay Memorial Hospital, Taipei, Taiwan.

Purple urine bag syndrome (PUBS) is rarely seen in clinical practice. Several studies have reported that PUBS is relatively benign in its clinical course, but this study aimed to identify risk factors for mortality related to PUBS. In a PubMed search from October 1980 to August 2016, using the search term "Purple urine bag syndrome (PUBS)", 106 articles (n = 174 cases) were identified. Read More

Sci Rep 2019 Mar 4;9(1):3421. Epub 2019 Mar 4.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt Universität zu Berlin, and Berlin Institute of Health, Department of Nephrology, Hindenburgdamm 30, 12203, Berlin, Germany.

Serum amyloid A (SAA) is an uremic toxin and acute phase protein. It accumulates under inflammatory conditions associated with high cardiovascular morbidity and mortality in patients with sepsis or end-stage renal disease (ESRD). SAA is an apolipoprotein of the high-density lipoprotein (HDL). Read More

CEN Case Rep 2019 Mar 4. Epub 2019 Mar 4.

Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama, Saitama, 330-8503, Japan.

A 44-year-old man undergoing automated peritoneal dialysis (PD) developed headache and dizziness with truncal ataxia and ataxic gait. Severe hypertension (systolic blood pressure/diastolic pressure: 193/83 mm Hg) and lower extremity edema were present, and his PD efficiency (weekly KT/V: 1.49) was inadequate. Read More

Can J Kidney Health Dis 2019 22;6:2054358119828391. Epub 2019 Feb 22.

University of British Columbia, Vancouver, Canada.

Purpose Of Review: Physical and psychological symptom burden in patients with advanced chronic kidney disease (CKD) is significantly debilitating; yet, it is often inadequately treated. Legalization of cannabis in Canada may attract increasing interest from patients for its medical use in refractory symptom management, but its indications and long-term adverse health impacts are poorly established, creating a challenge for clinicians to support its use. In this review, we summarize key clinical studies and the level of evidence for nonsynthetic cannabinoids in the treatment of common symptoms encountered in advanced stages of CKD, including chronic pain, nausea and vomiting, anorexia, pruritus, and insomnia. Read More

Medicine (Baltimore) 2019 Mar;98(9):e14656

Department of Ultrasound, the Second Affiliated Hospital of Dalian Medical University, Dalian, China.

The aim of this research is to evaluate the longitudinal and circumferential systolic function of the left ventricle with different configurations from endocardium, midmyocardium, and epicardium, respectively, in patients with uremia using layer-specific 2-dimensional speckle tracking echocardiography (2D-STE).According to the different left ventricular (LV) configurations, 119 patients with uremia were divided into 2 groups: LV normal group (LVN group, n = 63) and LV hypertrophy group (LVH group, n = 56). In all, 66 healthy volunteers were selected as controls. Read More

Nat Genet 2019 04;51(4):764

Division of Nephrology, Department of Medicine, Columbia University, New York, NY, USA.

In the version of this article initially published, affiliation 38 incorrectly read "ICNU-Nephrology and Urology Department, Barcelona, Spain"; "Renal Division, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain" is the correct affiliation. The error has been corrected in the HTML and PDF versions of the article. Read More

Tierarztl Prax Ausg K Kleintiere Heimtiere 2019 Feb 26;47(1):37-47. Epub 2019 Feb 26.

Klinik für kleine Haustiere, Freie Universität Berlin.

An impaired elimination of urinary excreted substances and an increase of these substances in the blood (azotemia) can also occur in rabbits and rodents. In addition to renal diseases, prerenal and postrenal conditions can induce azotemia. A systematic evaluation of patients with azotemia is needed to find a diagnosis and to initiate an effective treatment. Read More

Case Rep Rheumatol 2019 16;2019:7609386. Epub 2019 Jan 16.

Robert Wood Johnson Medical School, Piscataway Township, NJ, USA.

Granulomatosis with polyangiitis (GPA) is a rare ANCA-associated necrotizing granulomatous vasculitis affecting small- to medium-sized vessels. Common manifestations of this disease process affect the ear, nose, throat, upper and lower airways, and kidneys. Cardiac involvement has been reported in 6-44% of patients, primarily as coronary arteritis and pericarditis. Read More

Am J Case Rep 2019 Feb 25;20:248-251. Epub 2019 Feb 25.

Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

BACKGROUND Medications are one of the most common causes of acute kidney injury (AKI). Elderly patients with diabetes mellitus and chronic kidney disease seem to be at particularly high risk for development of medication-induced AKI. Among antibiotics, the most commonly implicated agents are aminoglycosides, cephalosporins, trimethoprim-sulfamethoxazole, acyclovir, and amphotericin. Read More

J Nutr 2019 Mar;149(3):372-380

Wolfson Wohl Translational Research Centre, Institute of Cancer Sciences, University of Glasgow, Bearsden, Glasgow, UK.

Epigenetic alterations, such as those linked to DNA methylation, may potentially provide molecular explanations for complications associated with altered gene expression in illnesses, such as chronic kidney disease (CKD). Although both DNA hypo- and hypermethylation have been observed in the uremic milieu, this remains only a single aspect of the epigenetic landscape and, thus, of any biochemical dysregulation associated with CKD. Nevertheless, the role of uremia-promoting alterations on the epigenetic landscape regulating gene expression is still a novel and scarcely studied field. Read More

Clin Interv Aging 2019 30;14:225-229. Epub 2019 Jan 30.

Department of Nephrology, University Côte d'Azur, University Hospital of Nice, Nice, France.

Purpose: Water balance disorders are associated with a high risk of death in elderly patients. The role of osmotic stress intensity and its direction toward hypo- or hypernatremia is a matter of controversy regarding patients' survival. The aims of this study were, first, to measure the frequency of cellular hydration disorders in patients over 75 years old hospitalized in nephrology department for reversible acute renal failure, and second, to compare the impact of hyperhydration and hypohydration on the risk of death at 6 months. Read More

BMJ Open 2019 Jan 15;9(1):e023736. Epub 2019 Jan 15.

Renal and Metabolic, The George Institute for Global Health, UNSW, Newtown, New South Wales, Australia.

Introduction: The majority of patients undergoing haemodialysis (HD) show evidence of uraemic neuropathy, a condition with no known disease-modifying treatments. The pathogenesis of uraemic neuropathy is poorly understood, but may be related to cumulative exposure to middle molecules or other solutes such as potassium. It is not known whether haemodiafiltration (HDF) reduces the progression of uraemic neuropathy. Read More

Mymensingh Med J 2019 Jan;28(1):1-7

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

The prevalence of chronic kidney disease (CKD) in Bangladesh is increasing. Chronic kidney disease refers to an irreversible deterioration in renal function which classically develops over a period of years. Initially, it manifest's only as a biochemical abnormality. Read More

Oncol Rev 2019 Jan 15;13(1):387. Epub 2019 Jan 15.

1 Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Greece.

Hydronephrosis is a sign of advanced stage disease in patients with cervical cancer. Its presence is believed to negatively affect the survival of patients. To date, however, consensus in this field is still lacking. Read More

J Chromatogr A 2019 May 28;1593:164-173. Epub 2019 Jan 28.

Department of Chemistry, National Changhua University of Education, Changhua, Taiwan. Electronic address:

A cyclodextrin-micellar electrokinetic chromatography (CD-MEKC) method has been developed to determine the apolipoproteins (apos) of human high-density lipoprotein (HDL). The optimal CD-MEKC conditions included a separation buffer mixture of 5 mM sodium phosphate, 40 mM bile salts (50% sodium cholate and 50% sodium deoxycholate), 25 mM carboxymethyl-β-CD (CM-β-CD) and pH 7.0. Read More