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BMC Ophthalmol 2020 Jun 1;20(1):211. Epub 2020 Jun 1.

Department of Ophthalmology, The Second Hospital of Tianjin Medical University, 23 Pingjiang street, Tianjin, 300221, China.

Background: To analyze the related factors of visual acuity after phacoemulsification and intraocular lens implantation in chronic renal failure (CRF) patients.

Methods: We retrospectively analyzed 42 patients (51 eyes) with CRF (failure, uremia) on hemodialysis or peritoneal dialysis and 40 patients (50 eyes) without CRF as a control group. Each individual underwent physical and laboratory examinations including best corrected visual acuity (BCVA), slit lamp examination, intraocular pressure, corneal endothelial cell count, fundus examination and optical coherence tomography (OCT) for macular examination. Read More

Transplant Proc 2020 May 29. Epub 2020 May 29.

Department of Urology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.

It is well known that correction of uremia by kidney transplantation alone (KTA) improves left ventricular systolic dysfunction (LVSD). However, for kidney transplant candidates with extremely severe LVSD, KTA is considered to be contraindicated because of the high risk of peri-operative management. We report a case of successful kidney transplantation with severe LVSD with an ejection fraction (EF) of 14% and low systolic blood pressure (SBP) of approximately 65 to 80 mm Hg. Read More

Toxins (Basel) 2020 May 21;12(5). Epub 2020 May 21.

Department of Internal Medicine II, Martin-Luther-University Halle-Wittenberg, 06120 Halle, Germany.

Monocytes play an important role in both innate immunity and antigen presentation for specific cellular immune defense. In patients with chronic renal failure, as well as those treated with maintenance hemodialysis, these cells are largely dysregulated. There is a large body of literature on monocyte alterations in such patients. Read More

Endocr Rev 2020 May 26. Epub 2020 May 26.

University of Washington, Division of Nephrology, Kidney Research Institute, and Institute of Translational Health Sciences.

Glucose and insulin metabolism in patients with diabetes are profoundly altered by advanced chronic kidney disease. Risk of hypoglycemia is increased by failure of kidney gluconeogenesis, impaired insulin clearance by the kidney, defective insulin degradation due to uremia, increased erythrocyte glucose uptake during hemodialysis, impaired counter-regulatory hormone responses (cortisol, growth hormone), nutritional deprivation and variability of exposure to oral anti-hyperglycemic agents and exogenous insulin. Patients with end stage kidney disease frequently experience wide glycemic excursions, with common occurrences of both hypoglycemia and hyperglycemia. Read More

J Vet Intern Med 2020 May 22. Epub 2020 May 22.

Veterinary Teaching Hospital, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot, Israel.

Background: Chronic kidney disease (CKD) and acute decompensation of CKD (ACKD) are common in cats.

Objectives: To characterize the etiology, clinical and clinicopathologic findings, and the short- and long-term prognosis of feline ACKD.

Animals: One hundred cats with ACKD. Read More

Biochem Biophys Res Commun 2020 May 18. Epub 2020 May 18.

Department of Cardiology, Chang Gung Memorial Hospital, and Chang Gung University College of Medicine, Taiwan.

Patients with chronic kidney diseases have multiple cellular dysfunctions leading to increased atherosclerosis, impaired immunity, and disturbed metabolism. However, it is unclear what is the fundamental signaling served as a marker or as a mediator for the dysregulated function in their leukocytes or tissues. Here we hypothesized that the N-Methyladenosine (mA) modification of the RNA in the leukocytes is responsible for the cellular dysfunction in chronic kidney diseases. Read More

Panminerva Med 2020 May 20. Epub 2020 May 20.

Neonatal Intensive Care Unit, AOU Cagliari, Cagliari, Italy.

The etiology of injury in COVID-19 patients is diverse and multifactorial. Autopsy and biopsy studies reveal, alongside podocyte and tubular cell anomalies, the presence of virion within the cells. Evidence suggests that, in addition to the direct cytopathic effect of SARS- CoV2 on the glomeruli and renal tubules, there is also the indirect effect of cell-mediated immunity, the cytokines storm and the cross-talk between organs with possible systemic effects of the disease. Read More

Gland Surg 2020 Apr;9(2):321-328

Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210000, China.

Background: This study aimed to investigate the clinical efficacy of two surgical methods on hyperparathyroidism secondary to uremia and summarize the advantages and disadvantages of both methods.

Methods: Uremic patients who received parathyroidectomy (PTX) in the last 3 years were divided into two groups according to the surgical methods used [subtotal parathyroidectomy (SPTX) group and total parathyroidectomy + autologous implantation (TPTX + AT) group]. TPTX was performed if less than 4 glands were found during surgery. Read More

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620918095

Morehouse School of Medicine, Atlanta, GA, USA.

Hyponatremia is the most common electrolyte abnormality encountered both in the inpatient and outpatient clinical settings in the United States. Rapid correction leads to a deranged cerebral osmotic gradient causing osmotic demyelination syndrome. Coexisting azotemia is considered to be protective against osmotic demyelination syndrome owing to its counteractive effect on osmolarity change that occurs with rapid hyponatremia correction. Read More

Saudi J Kidney Dis Transpl 2020 Mar-Apr;31(2):298-311

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Electrophoresis 2020 May 10. Epub 2020 May 10.

Department of Chemistry, National Changhua University of Education, Changhua, Taiwan.

The apolipoproteins (APOs) of human very low-density lipoprotein (VLDL) were investigated by an optimized cyclodextrin-micellar electrokinetic chromatography (CD-MEKC) method. The separation buffer consisted of 20 mM sodium phosphate, 40 mM bile salts (50% sodium cholate and 50% sodium deoxycholate), 25 mM carboxymethyl-β-cyclodextrin (CM-β-CD) (pH 7.0). Read More

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 Mar;32(3):324-329

Department of Respiratory Intensive Care Unit, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China. Corresponding author: Xu Sicheng, Email:

Objective: To explore the timing of sequential noninvasive positive pressure ventilation (NIPPV) following endotracheal intubation mechanical ventilation (ETI-MV) in aged patients with severe community-acquired pneumonia (SCAP).

Methods: A prospective cohort study was conducted. The SCAP patients aged ≥ 75 years old admitted to respiratory intensive care unit (RICU) of the First Affiliated Hospital of Xinjiang Medical University from July 2017 to August 2019 were enrolled. Read More

PLoS One 2020 4;15(5):e0232522. Epub 2020 May 4.

Transplant and Dialysis Unit, Teaching Hospital, Kandy, Sri Lanka.

Chronic Kidney Disease of uncertain etiology (CKDu) is an endemic, disease that mostly affects young agricultural workers in the rural dry zone of Sri Lanka. This study was designed to identify specific biochemical manifestations of CKDu cases. All (119) non-dialysis definite CKDu patients in Girandurukotte and Wilgamuwa were selected. Read More

Clin Pharmacol Ther 2020 May 1. Epub 2020 May 1.

Section for Pharmacology and Pharmaceutical Biosciences, Department of Pharmacy, University of Oslo, Oslo, Norway.

Drug dosing is challenging in patients with end-stage renal disease. Not only is renal drug elimination reduced, but nonrenal clearance pathways are also altered. Increasing evidence suggest that uremia impacts drug metabolizing enzymes and transporters leading to changes in nonrenal clearance. Read More

Photodiagnosis Photodyn Ther 2020 Apr 27:101792. Epub 2020 Apr 27.

Physics and Chemistry Detecting Center, Xinjiang University, Urumqi 830046, China.

Chronic renal failure (CRF) is a symptom of kidney damage in the terminal stages. If a patient is not treated, then CRF will progress to uremia, which greatly reduces the lifespan of the patient. However, current screening strategies, including routine urine tests and medical imaging investigations, have poor sensitivity. Read More

Nutrients 2020 Apr 27;12(5). Epub 2020 Apr 27.

Department of Experimental Diagnostic and Specialty Medicine (DIMES), Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, 40138 Bologna, Italy.

Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated by methyl donors (folate, methionine, choline, betaine), and cofactors (vitamin B6, vitamin B12,). Read More

Cureus 2020 Mar 22;12(3):e7368. Epub 2020 Mar 22.

Internal Medicine, Saint Michael's Medical Center, Newark, USA.

Starvation-induced ketoacidosis in non-diabetic and non-pregnant, otherwise healthy patients is not common. In an otherwise normal healthy individual, short-term starving will only result in mild ketosis. Nonetheless, the effects of ketosis can become more severe if there is stress and insulin resistance, such as in pregnant or lactating woman or in very young individual such as neonates. Read More

Urology 2020 Apr 20. Epub 2020 Apr 20.

Department of Urology, Stepping Hill Hospital, Stockport NHS Foundation Trust, Poplar Grove, United Kingdom.

High-pressure chronic retention (HPCR) is a well-recognized common urological emergency which requires prompt treatment. It usually presents with nocturnal enuresis, a tense and palpable bladder, and symptoms of uraemia from renal failure George et al 1983. There have been isolated cases in the literature of HPCR presenting with symptoms of venous occlusion secondary to extrinsic bladder compression but it remains a rare presenting complaint. Read More

Int Urol Nephrol 2020 Apr 22. Epub 2020 Apr 22.

Department of Microbiology and Immunology, Faculty of Medicine, Uludag University, Bursa, Turkey.

Aim: Skin test anergy is common in patients with uremia and during maintenance hemodialysis treatment. However, up to date only one study concerning skin test in peritoneal dialysis patients has focused on the issue. Our cross-sectional controlled study was conducted to analyze the correlation of purified protein derivative (PPD) test response with demographical features, nutritional parameters and the distribution of peripheral blood lymphocyte subsets in peritoneal dialysis and hemodialysis patients PATIENTS AND METHODS: Stable 30 hemodialysis (HD) patients (16 men, 14 women) and 30 continuous ambulatory peritoneal dialysis (PD) patients (17 men, 13 women) were included. Read More

Curr Vasc Pharmacol 2020 Apr 19. Epub 2020 Apr 19.

Department of Nephrology, Aristotle University of Thessaloniki, General Hospital "Hippocration", Thessaloniki. Greece.

Alterations of fibroblast growth factor 23 (FGF-23) and Klotho levels are considered to be the earliest biochemical abnormality of chronic kidney disease - mineral and bone disease (CKD-MBD) syndrome. Moreover, emerging data suggests that the dysregulated FGF-23 and Klotho axis has many effects on the cardiovascular (CV) system and contributes significantly to the increased CV morbidity and mortality rates of CKD patients. This review examines recent evidence on the role of FGF-23 and Klotho in the development and progression of CV complications of uremia namely cardiac hypertrophy, uremic cardiomyopathy and atherosclerotic and arteriosclerotic vascular lesions. Read More

J Ren Nutr 2020 Apr 14. Epub 2020 Apr 14.

Treatment Study Group of Chronic Renal Disease of Italian Society of Nephrology, Cagliari, Italy. Electronic address:

Objective: The objective of the study was to quantify the loss and arterial blood concentration of the three main classes of amino acids (AAs)-nonessential amino acids (NEAAs), essential amino acids (EAAs), and branched-chain amino acids-as resulting from high-efficiency hemodialysis (HED) and hemodiafiltration (HDF). We moreover aimed to identify the different fates and metabolic effects manifested in patients undergoing hemodialysis and the consequences on body composition and influence of nutritional decline into protein energy wasting.

Design And Methods: Identical dialysis monitors, membranes, and dialysate/infusate were used to ensure consistency. Read More

G Ital Nefrol 2020 Apr 9;37(2). Epub 2020 Apr 9.

Divisione di Fisica Medica - P.O. "San Giovanni di Dio", Agrigento (AG), Itali.

In recent years imaging techniques that use radionuclides have become more and more clinically relevant as they can provide functional information for specific anatomical districts. This has also involved nephrology, where radionuclides are used to study patients with different degrees of renal function failure up to terminal uremia. Although chronic kidney disease, and dialysis in particular, may affect the distribution and the elimination of radiopharmaceuticals, to date there are no consistent data on the risks associated with their use in this clinical context. Read More

Basic Res Cardiol 2020 Apr 9;115(3):30. Epub 2020 Apr 9.

Kidney Institution of the Chinese People's Liberation Army, Chang Zheng Hospital, the Second Military Medical University, Feng Yang Road, No. 415, Huangpu District, Shanghai, China.

Heart failure is the leading cause of mortality in patients with end-stage renal disease, and progressive cardiac remodeling is the key pathological basis of heart failure. However, the mechanism by which uremia-induced cardiac remodeling occurs is not well understood. Here, we showed that platelets were significantly activated in 5/6 nephrectomy-operated mice, and cardiac remodeling in the uremic mice was significantly improved when platelets were effectively depleted. Read More

Indian J Nephrol 2020 Mar-Apr;30(2):63-71. Epub 2020 Feb 26.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, CA, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5 most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Front Cell Dev Biol 2020 20;8:185. Epub 2020 Mar 20.

Departamento Biología de Sistemas, Facultad de Medicina y Ciencias de la Salud (IRYCIS), Universidad de Alcalá, Alcalá de Henares, Madrid, Spain.

Cardiovascular diseases (CVDs), especially those involving a systemic inflammatory process such as atherosclerosis, remain the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). CKD is a systemic condition affecting approximately 10% of the general population. The prevalence of CKD has increased over the past decades because of the aging of the population worldwide. Read More

BMC Surg 2020 Apr 7;20(1):67. Epub 2020 Apr 7.

Pancreas Center, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu, China.

Background: The diagnosis of gallbladder tuberculosis remains elusive even to the most experienced clinicians. Our aim is to describe our experience of this rare disease, and to raise awareness of the increasing likelihood of tuberculosis in chronic kidney disease (CKD) patient.

Case Presentation: We report a rare case of gallbladder tuberculosis in a chronic kidney disease patient on hemodialysis. Read More

Toxins (Basel) 2020 Apr 3;12(4). Epub 2020 Apr 3.

Department of Internal Medicine, Division of Nephrology and Transplantation, Erasmus Medical Centre, Rg5, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands.

Progressive loss of renal function is associated with a series of changes of the adaptive immune system which collectively constitute premature immunological ageing. This phenomenon contributes significantly to the mortality and morbidity of end-stage renal disease (ESRD) patients. In this review, the effect of ESRD on the T cell part of the adaptive immune system is highlighted. Read More

Cureus 2020 Feb 28;12(2):e7131. Epub 2020 Feb 28.

Internal Medicine, King Edward Medical University/Mayo Hospital, Lahore, PAK.

Multiple different types of mediastinal masses may be encountered on imaging techniques in symptomatic and asymptomatic patients. The most frequent mediastinal masses in adults are thymoma, lymphoma, thyroid masses, and germ cell tumors. Potential complications of these masses due to localized invasion include hemoptysis, post-obstructive pneumonia, and superior vena cava syndrome. Read More

Biochem J 2020 May;477(10):1907-1921

Department of Nephrology, Linyi People's Hospital, Linyi 2760003, P. R. China.

Continuous exposure to peritoneal dialysis (PD) fluid results in peritoneal fibrosis and ultimately causes ultrafiltration failure. Noncoding RNAs, including long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), have been reported to participate in ultrafiltration failure in PD. Therefore, our study aimed to investigate the mechanism of lncRNA 6030408B16RIK in association with miR-326-3p in ultrafiltration failure in PD. Read More

Am J Physiol Renal Physiol 2020 May 6;318(5):F1188-F1198. Epub 2020 Apr 6.

Department of Animal Medicine and Surgery, University of Cordoba, Campus Universitario Rabanales, Cordoba, Spain.

Caloric restriction (CR) is known to have multiple beneficial effects on health and longevity. To study the effect of CR on phosphorus metabolism and vascular calcification (VC), rats were fed normal or restricted calories (67% of normal). The phosphorus content of the diets was adjusted to provide equal phosphorus intake independent of the calories ingested. Read More

J Nephrol 2020 Apr;33(2):201-210

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, CA, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Nephron 2020 27;144(5):245-247. Epub 2020 Mar 27.

Division of Nephrology, Changzheng Hospital, Second Military Medical University, Shanghai, China,

Since December 2019, the epidemic of coronavirus disease 2019 (COVID-19) has spread very rapidly in China and worldwide. In this article, we report on a 75-year-old man infected with 2019 novel coronavirus who has end-stage kidney disease (ESKD). COVID-19 patients with ESKD need isolation dialysis, but most of them cannot be handled in time due to limited continuous renal replacement therapy (CRRT) machines. Read More

Can J Kidney Health Dis 2020 10;7:2054358120910569. Epub 2020 Mar 10.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the fifth most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual health care budget in high-income countries. Read More

J Surg Res 2020 Mar 23;252:9-15. Epub 2020 Mar 23.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas.

Background: The optimal surgical technique for drainage of pericardial effusions is frequently debated. Transpleural drainage via thoracotomy or thoracoscopy is hypothesized to provide more durable freedom from recurrent pericardial effusion than a subxiphoid pericardial window. We sought to compare operative outcomes and mid-term freedom from recurrent effusion between both approaches in patients with nontraumatic pericardial effusions. Read More

Arch Argent Pediatr 2020 04;118(2):e148

Renal Unit, Department of Medicine, College of Medicine, University of Nigeria, Ituku-Ozalla, Enugu, Nigeria.

Chronic kidney disease (CKD) is rapidly becoming the 5th most common cause of years of life lost globally by 2040. Crucially, the onset and progression of CKD is often preventable. The World Kidney Day 2020 campaign highlights the importance of preventive interventions on CKD. Read More

J Biol Chem 2020 May 20;295(19):6330-6343. Epub 2020 Mar 20.

Institute of Physiology and Pathophysiology, Friedrich-Alexander-University Erlangen-Nürnberg, Universitätsstrasse 17, 91054 Erlangen, Germany

The plasmas of diabetic or uremic patients and of those receiving peritoneal dialysis treatment have increased levels of the glucose-derived dicarbonyl metabolites like methylglyoxal (MGO), glyoxal (GO), and 3-deoxyglucosone (3-DG). The elevated dicarbonyl levels can contribute to the development of painful neuropathies. Here, we used stimulated immunoreactive Calcitonin Gene-Related Peptide (iCGRP) release as a measure of nociceptor activation, and we found that each dicarbonyl metabolite induces a concentration-, TRPA1-, and Ca-dependent iCGRP release. Read More

Curr Vasc Pharmacol 2020 Mar 20. Epub 2020 Mar 20.

Aristotle University of Thessaloniki, Division of Nephrology and Hypertension, 1st Department of Internal Medicine, AHEPA Hospital, Medical School, 1 Kyriakidi str.. Greece.

In Chronic Kidney Disease, vascular calcification (VC) is highly prevalent even at early stages and is gradually enhanced, along with disease progression to End-Stage Renal Disease (ESRD). The calcification pattern in uremia includes all types of mineralization and contributes to the heavy cardiovascular (CV) burden that is common in these patients. Ectopic mineralization is the result of the imbalance between inhibitors and promoters of vascular calcification, with the latter overwhelming the former. Read More

Mediators Inflamm 2020 27;2020:8937657. Epub 2020 Feb 27.

Unidad de Biotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de Jalisco, A.C, Guadalajara, Jalisco, Mexico.

Chronic kidney disease (CKD) causes anemia by renal damage. In CKD, the kidney is submitted to hypoxia, persistent inflammation, leading to fibrosis and permanent loss of renal function. Human recombinant erythropoietin (rEPO) has been widely used to treat CKD-associated anemia and is known to possess organ-protective properties that are independent from its well-established hematopoietic effects. Read More

J Atheroscler Thromb 2020 Mar 14. Epub 2020 Mar 14.

Department of Internal Medicine, Nephrology, Dialysis and Transplantation Clinics, Genoa University and IRCCS Ospedale Policlinico San Martino.

Aim: Myostatin (Mstn) has been described as a trigger for the progression of atherosclerosis. In this study, we evaluated the role of Mstn in arterial remodeling in patients with end-stage renal disease (ESRD).

Methods: Vascular specimens were collected from 16 ESRD patients (56. Read More

Diagnostics (Basel) 2020 Mar 11;10(3). Epub 2020 Mar 11.

Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 81108 Bratislava, Slovakia.

Current diagnostic methods of acute kidney injury (AKI) have limited sensitivity and specificity. Tissue injury has been linked to an increase in the concentrations of extracellular DNA (ecDNA) in plasma. A rapid turnover of ecDNA in the circulation makes it a potential marker with high sensitivity. Read More

J Clin Med 2020 Mar 11;9(3). Epub 2020 Mar 11.

Unit of Immunology and Chronic Disease, Institute of Environmental Medicine, Karolinska Institutet, 17177 Stockholm, Sweden.

Patients on haemodialysis (HD-patients) have an increased risk of premature death. Low levels of IgM antibodies against malondialdehyde (anti-MDA) are associated with increased risk of cardiovascular disease (CVD) with underlying potential mechanisms described. Here, we studied subclasses and isotypes of anti-MDA in 210 HD-patients with mortality as outcome (56% men, median age 66, Interquartile range (IQR) 51-74 years, vintage time 29 (15-58) months, mean follow up period of 41 (20-60)months). Read More

Iran J Kidney Dis 2020 Mar;14(2):69-80

Department of Medicine and Therapeutics, Carol and Richard Yu PD Research Centre, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Blood Purif 2020 Mar 11:1-8. Epub 2020 Mar 11.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Am J Nephrol 2020 11;51(4):255-262. Epub 2020 Mar 11.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA,

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Nephron 2020 11;144(4):162-169. Epub 2020 Mar 11.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, California, USA,

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Braz J Med Biol Res 2020 9;53(3):e9614. Epub 2020 Mar 9.

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, CA, USA.

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More

Toxins (Basel) 2020 Mar 5;12(3). Epub 2020 Mar 5.

Clinic for Renal and Hypertensive Disorders, Rheumatological and Immunological Disease, University Hospital of the RWTH Aachen, 52074 Aachen, Germany.

Cardiac remodeling occurs frequently in chronic kidney disease patients and affects quality of life and survival. Current treatment options are highly inadequate. As kidney function declines, numerous metabolic pathways are disturbed. Read More

Clin Res Hepatol Gastroenterol 2020 Mar 3. Epub 2020 Mar 3.

Division of Nephrology, Maggiore Hospital and IRCCS Foundation, Pad. Croff, Via Commenda 15, 20122 Milano, Italy; University School of Medicine, Milan, Italy.

Background: Patients on regular dialysis show a poor response to hepatitis B vaccine due to uremia. A recombinant HB vaccine (containing an improved adjuvant system AS04, HBV-AS04) has been licensed but the evidence on its efficacy and safety in dialysis population over the long term is extremely limited.

Aim: We have measured antibody (anti-HBs) persistence for up to 72 months in a large cohort of patients on long-term dialysis (with susceptibility to HBV infection) who underwent vaccination with HBV-AS04 vaccine. Read More

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2020 Feb;42(1):124-127

Emergency Department,Zhongda Hospital,Southeast University,Nanjing 210009,China.

Patients with uremia can suffer from decreased renal function and endocrine and metabolism disorders,which can lead to the accumulation of toxins in the body.Accumulation of uremic toxins is a major cause of cognitive dysfunction in uremic patients.This article summarizes some of the cognitive dysfunction-related uremic toxins and their possible mechanisms. Read More

Nefrologia 2020 Mar - Apr;40(2):133-141

Division of Nephrology and Hypertension and Kidney Transplantation, University of California Irvine School of Medicine, Orange, CA, USA. Electronic address:

The global burden of chronic kidney disease (CKD) is rapidly increasing with a projection of becoming the 5th most common cause of years of life lost globally by 2040. Aggravatingly, CKD is a major cause of catastrophic health expenditure. The costs of dialysis and transplantation consume up to 3% of the annual healthcare budget in high-income countries. Read More