Search Our Scientific Publications & Authors

BMJ Open 2019 Jan 15;9(1):e023736. Epub 2019 Jan 15.

Renal and Metabolic, The George Institute for Global Health, UNSW, Newtown, New South Wales, Australia.

Introduction: The majority of patients undergoing haemodialysis (HD) show evidence of uraemic neuropathy, a condition with no known disease-modifying treatments. The pathogenesis of uraemic neuropathy is poorly understood, but may be related to cumulative exposure to middle molecules or other solutes such as potassium. It is not known whether haemodiafiltration (HDF) reduces the progression of uraemic neuropathy. Read More

Mymensingh Med J 2019 Jan;28(1):1-7

Dr Mohammad Omar Faruque Miah, Senior Clinical Pathologist, Mymensingh Medical College Hospital, Mymensingh, Bangladesh.

The prevalence of chronic kidney disease (CKD) in Bangladesh is increasing. Chronic kidney disease refers to an irreversible deterioration in renal function which classically develops over a period of years. Initially, it manifest's only as a biochemical abnormality. Read More

Oncol Rev 2019 Jan 15;13(1):387. Epub 2019 Jan 15.

1 Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, Greece.

Hydronephrosis is a sign of advanced stage disease in patients with cervical cancer. Its presence is believed to negatively affect the survival of patients. To date, however, consensus in this field is still lacking. Read More

J Chromatogr A 2019 Jan 28. Epub 2019 Jan 28.

Department of Chemistry, National Changhua University of Education, Changhua, Taiwan. Electronic address:

A cyclodextrin-micellar electrokinetic chromatography (CD-MEKC) method has been developed to determine the apolipoproteins (apos) of human high-density lipoprotein (HDL). The optimal CD-MEKC conditions included a separation buffer mixture of 5 mM sodium phosphate, 40 mM bile salts (50% sodium cholate and 50% sodium deoxycholate), 25 mM carboxymethyl-β-CD (CM-β-CD) and pH 7.0. Read More

Nat Rev Nephrol 2019 Feb 6. Epub 2019 Feb 6.

Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.

Uraemic syndrome (also known as uremic syndrome) in patients with advanced chronic kidney disease involves the accumulation in plasma of small-molecule uraemic solutes and uraemic toxins (also known as uremic toxins), dysfunction of multiple organs and dysbiosis of the gut microbiota. As such, uraemic syndrome can be viewed as a disease of perturbed inter-organ and inter-organism (host-microbiota) communication. Multiple biological pathways are affected, including those controlled by solute carrier (SLC) and ATP-binding cassette (ABC) transporters and drug-metabolizing enzymes, many of which are also involved in drug absorption, distribution, metabolism and elimination (ADME). Read More

Clin J Am Soc Nephrol 2019 Feb 6. Epub 2019 Feb 6.

Renal Division, Ghent University Hospital, Ghent, Belgium.

eNeurologicalSci 2019 Mar 16;14:85-88. Epub 2019 Jan 16.

Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

The syndrome of acute bilateral basal ganglia lesions in diabetic uremia is uncommon and usually affects Asian patients. The underlying pathogenesis of this syndrome is not clear. We searched PUBMED using the keywords "bilateral basal ganglia", "diabetic", and "uremia", and found a total of 34 cases from 1998 to 2016. Read More

Toxins (Basel) 2019 Feb 1;11(2). Epub 2019 Feb 1.

Department of Nephrology and Dialysis, Medical University of Vienna, Vienna A-1090, Austria.

The anti-inflammatory properties of high-density lipoproteins (HDL) are lost in uremia. These HDL may show pro-inflammatory features partially as a result of changed protein composition. Alterations of polymorphonuclear leukocytes (PMNLs) in chronic kidney disease (CKD) may contribute to chronic inflammation and high vascular risk. Read More

Nephrol Dial Transplant 2019 Feb 1. Epub 2019 Feb 1.

Department of Nephrology, University Hospital of the RWTH Aachen, Aachen, Germany.

Background: Optimal phosphate control is an unmet need in chronic kidney disease (CKD). High serum phosphate increases calcification burden and is associated with mortality and cardiovascular disease in CKD. Nicotinamide (NA) alone or in combination with calcium-free phosphate binders might be a strategy to reduce phosphate levels and calcification and thus impact cardiovascular disease in CKD. Read More

Neurol Sci 2019 Feb 1. Epub 2019 Feb 1.

Department of Neurology, Chonbuk National University Medical School, Jeonju, 54907, South Korea.

Respir Res 2019 Jan 31;20(1):22. Epub 2019 Jan 31.

Guangzhou Institute of Respiratory Diseases (State Key Laboratory of Respiratory Diseases), First Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510120, Guangdong, China.

Background: Infectious Disease Society of America/American Thoracic Society (IDSA/ATS) minor criteria for severe community-acquired pneumonia (CAP) are of unequal weight in predicting mortality, but the major problem associated with IDSA/ATS minor criteria might be a lack of consideration of weight in prediction in clinical practice. Would awarding different points to the presences of the minor criteria improve the accuracy of the scoring system? It is warranted to explore this intriguing hypothesis.

Methods: A total of 1230 CAP patients were recruited to a retrospective cohort study. Read More

Front Pharmacol 2018 15;9:1573. Epub 2019 Jan 15.

Department of Pharmacy, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Heavy menstrual bleeding (HMB), previously known as menorrhagia, is in place with heavy flow and longer lasting days of bleeding during menstrual period, sequentially leading to anemia. We reported a rare case of HMB in a 33-year-old patient after percutaneous coronary intervention (PCI), who presented with acute coronary syndromes (ACS), uremia and systemic lupus erythematosus before PCI. This patient received three times of hemodialysis weekly (Monday, Wednesday, and Friday). Read More

Clin Calcium 2019 ;29(2):157-163

Department of Cardiovascular Medicine, Gunma University Graduate School of Medicine, Maebashi, Japan.

Intimal and medial calcification are increased with type 1 and type 2 diabetes, metabolic syndrome, chronic kidney disease, and ageing. There are several biological mechanisms through which vascular calcification increases all-cause mortality and atherosclerotic plaque rupture. Arterial medial calcification increases arterial stiffness that causes systolic hypertension and diastolic dysfunction and heart failure. Read More

AJNR Am J Neuroradiol 2019 Feb 24;40(2):267-275. Epub 2019 Jan 24.

From the Department of Radiology (C.Ö., S.K.R., J.C.B., J.B.R., A.M.M.).

Background And Purpose: Prior studies regarding acute toxic leukoencephalopathy (ATL) are either small, or preliminary. Our aim was to evaluate etiologies of and differences in imaging severity and outcomes among various etiologies of ATL.

Materials And Methods: MRIs of patients with suspected ATL over 15 years were retrospectively reviewed; inclusion criteria were: MRI <3 weeks of presentation with both DWI and FLAIR. Read More

J Nephrol 2019 Jan 23. Epub 2019 Jan 23.

Department of Precision Medicine, School of Medicine, University of Campania "Luigi Vanvitelli", Via Luigi de Crecchio 7, 80138, Naples, Italy.

The gut microbiota is considered to be a novel important factor to take into account in the pathogenesis of chronic kidney disease and uremia. Much attention has been paid to specific uremic retention solutes of microbial origin, such as indoxyl sulfate, p-cresyl sulfate, and trimethylamine-N-oxide. However, other novel less well studied compounds, such as hydrogen sulfide and related sulfur metabolites (sulfane sulfur, lanthionine, etc. Read More

Rev Assoc Med Bras (1992) 2018 Aug;64(8):680-683

. Internal Medicine Department, Medicine Service III - Santarém Hospital - Santarém, Santarém, Portugal.

Sodium polystyrene sulfonate (PSP) or Kayexalate is a cation-exchange resin, widely used in the management of hyperkalaemia due to renal disease. A rare, yet potentially dangerous, adverse event related to sodium polystyrene sulfonate use is intestinal mucosal injury, especially in the colon. The injury to the gastrointestinal mucosa can range from mild and superficial to wall necrosis and bowel perforation. Read More

Clin J Am Soc Nephrol 2019 Jan 21. Epub 2019 Jan 21.

Division of Nephrology and Hypertension, Department of Medicine, Case Western Reserve University, Cleveland, Ohio

Cancer Chemother Pharmacol 2019 Jan 19. Epub 2019 Jan 19.

Inorganic Chemistry Center (CONICET-UNLP) Exact School Sciences, National University of La Plata, 1900, La Plata, Argentina.

Platinum-based drugs, mainly cisplatin, are used for the treatment of several solid tumors such as OS. However, cisplatin treatment often results in the development of chemoresistance, leading therapeutic failure. We have previously reported that platinum complexes containing 8-hydroxyquinoline ligands have good antitumor activity against different cancer cell lines and with a different and better cytotoxic profile than cisplatin. Read More

Clin Case Rep 2019 Jan 12;7(1):244-245. Epub 2018 Dec 12.

Division of Nephrology, Hypertension and Renal Transplantation University of Florida Gainesville Florida.

Optic neuropathy is an uncommon finding in dialysis patients and has been associated with uremia, ischemia (arteritic and nonarteritic), drugs (isoniazid, ethambutol), infections (tuberculosis), and intracranial hypertension. Inflammatory optic neuritis associated with lupus is relatively rare, but clinicians need to be aware of this condition and obtain urgent ophthalmology consultation. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1251-1256

Department of Nephrology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Calcific uremic arteriopathy (CUA), termed calciphylaxis, is a rare but highly fatal clinical syndrome. There is no clearly laboratory diagnostic criteria for CUA. The medium and small arterial calcification and microthrombosis discovered by skin biopsy, radiologic imaging，bone scan and the evidence of activation of the bone morphogenetic protein signal (BMPs) transduction pathway are useful for early diagnosis of this disease. Read More

Kidney Res Clin Pract 2018 Dec 31;37(4):315-322. Epub 2018 Dec 31.

Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

The high mortality rates associated with acute kidney injury are mainly due to extra-renal complications that occur following distant-organ involvement. Damage to these organs, which is commonly referred to as multiple organ dysfunction syndrome, has more severe and persistent effects. The brain and its sub-structures, such as the hippocampus, are vulnerable organs that can be adversely affected. Read More

Int J Biol Macromol 2019 Apr 5;126:1255-1265. Epub 2019 Jan 5.

Department of Biochemistry, Higher Education Institute of Rab-Rashid, Tabriz, Iran.

Ovarian cancer (OC) is known to be one of the most lethal malignancies associated with women disease. The CA-125 protein is a repetitive epitope of MUC-16, which plays key role in enhancing the proliferation of cancer cells and inhibiting anticancer immune responses. It is the most widely used biomarker for early stage diagnosis of OC. Read More

Afr Health Sci 2018 Sep;18(3):671-680

Renal Unit, department of Medicine, Obafemi Awolowo University Teaching Hospital, Ile-Ife, Nigeria.

Introduction: Autosomal Dominant Polycystic Kidney Disease (ADPKD) is presumably rare in Africa. Knowledge about the disease in Nigeria is limited as demonstrated by scanty articles on the subject.

Objectives: To determine the pattern of clinical presentation and outcome of ADPKD among ADPKD patients. Read More

J Diabetes Res 2018 25;2018:7926473. Epub 2018 Nov 25.

Federal University of São Paulo, Brazil.

Background: Patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (DM) have increased risk of endothelial dysfunction, cardiovascular disease, and mortality. Several studies have separately analyzed endothelial function in these populations. However, data of patients with both CKD and DM are scarce. Read More

J Am Heart Assoc 2019 Jan;8(1):e011211

1 Department of Cardiovascular Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China.

Background The arteriovenous fistula ( AVF ) is the preferred hemodialysis access for patients with chronic kidney disease. Chronic kidney disease can increase neointima formation, which greatly contributes to AVF failure by an unknown mechanism. Our study aimed to determine the role of nucleotide-binding oligomerization domain-like receptor protein 3 ( NLRP 3) in neointima formation induced by experimental AVF s in the presence of chronic kidney disease. Read More

Clin Biochem 2018 Dec 19. Epub 2018 Dec 19.

Department of Emergency Medicine, Mayo Clinic, Rochester, MN, United States.

A 35-month-old female with nonketotic hyperglycinemia (NKH) presented to the Emergency department with severe hypoglycemia, fever, and several episodes of seizures. Due to worsening respiratory status, additional seizures and anion gap worsening metabolic acidosis the patient was transferred to the pediatric intensive care unit. The useful mnemonics for causes of high anion gap metabolic acidosis are the classic MUDPILES (representing Methanol, Uraemia, Diabetes, Paraldehyde, Iron (and Isoniazid), Lactate, Ethylene glycol, and Salicylate) and the more recently proposed GOLD MARK (Glycols [ethylene and propylene], Oxoproline, l-lactate, d-lactate, Methanol, Aspirin, Renal failure, and Ketoacidosis) as causes of the anion gap metabolic acidosis were all ruled out. Read More

Nat Genet 2019 Jan 21;51(1):117-127. Epub 2018 Dec 21.

Division of Nephrology, Department of Medicine, Columbia University, New York, NY, USA.

Congenital anomalies of the kidney and urinary tract (CAKUT) are a major cause of pediatric kidney failure. We performed a genome-wide analysis of copy number variants (CNVs) in 2,824 cases and 21,498 controls. Affected individuals carried a significant burden of rare exonic (that is, affecting coding regions) CNVs and were enriched for known genomic disorders (GD). Read More

Transplant Proc 2018 Dec 10;50(10):3483-3486. Epub 2018 Jul 10.

The Children's Memorial Health Institute, Warsaw, Poland. Electronic address:

Objective: There are no specific recommendations for therapeutic plasma exchange (TPE) in children after renal transplantation. The purpose of this study was to report the experience with TPE in a pediatric transplant setting.

Materials And Methods: 59 patients (mean age 12. Read More

J Pediatr Ophthalmol Strabismus 2018 Dec 19;55:e49-e51. Epub 2018 Dec 19.

Ocular involvement in hemolytic uremic syndrome is rare and in most cases presents with retinal ischemia, hemorrhages, and neovascularization. The authors describe the progression of retinal involvement as a rare complication of typical hemolytic uremic syndrome in a 2-year-old boy. Progression of retinal findings were demonstrated with serial fundus photographs. Read More

Ochsner J 2018 ;18(4):417-422

Department of Pediatric Critical Care, Ochsner Clinic Foundation, New Orleans, LA.

Background: Common neonatal etiologies of acute kidney injury (AKI) include renal vein and inferior vena cava thromboses, maternal use of nonsteroidal antiinflammatory drugs, and congenital renal disease. The incidence of renal vein thrombosis is estimated to be 0.5 per 1,000 neonatal intensive care unit admissions, with approximately half of cases extending to the inferior vena cava and with unilateral disease being significantly more common than bilateral. Read More

Molecules 2018 Dec 14;23(12). Epub 2018 Dec 14.

Institute of Special Animal and Plant Sciences, Chinese Academy of Agricultural Sciences, Changchun 130112, China.

N-(Carboxymethyl) lysine (CML) and N-(carboxyethyl) advanced glycation end-products (AGEs) and are frequently used as markers of AGE formation. AGEs, such as CML and CEL, have harmful effects in the human body and have been closely linked to many diseases such as diabetes and uremia. However, details on the contents of CML and CEL after applying different antler velvet processing methods are lacking. Read More

Medicine (Baltimore) 2018 Dec;97(50):e13614

Department of Nephrology.

Rationale: It is reported that successful pregnancies in dialyzed uremic women are rare. Over the past years, despite advances in clinical management and technology in dialysis for pregnancy in patients receiving maintenance hemodialysis, uremia remains a high risk factor for adverse outcomes in mother and fetus.

Patient Concerns: In this article, we present a case of pregnancy in a 34-year-old uremic woman on dialysis. Read More

Proteomics Clin Appl 2018 Dec 17:e1800117. Epub 2018 Dec 17.

Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, Beijing, Xicheng, 100044, P. R. China.

Purpose: Pentraxin-3 (PTX3) is a nonspecific marker of disease severity; however, PTX3 data from community-acquired pneumonia (CAP) patients are lacking.

Experimental Design: An observational, prospective study of CAP patients was conducted in 2016. Plasma PTX3 levels are determined with quantitative ELISA. Read More

J Cell Physiol 2018 Dec 17. Epub 2018 Dec 17.

Children's Medical Center, University of Chinese Academy of Sciences Shenzhen Hospital, Shenzhen, China.

Uremia can affect hepatic metabolism of drugs by regulating the clearance of drugs, but it has not been clarified whether gene silencing could modulate the epithelial-mesenchymal transition (EMT) process in uremia. Hence, we investigated the effect of WISP1 gene silencing on the renal tubular EMT in uremia through the wnt/β-catenin signaling pathway. Initially, microarray-based gene expression profiling of uremia was used to identify differentially expressed genes. Read More

Pediatr Nephrol 2018 Dec 14. Epub 2018 Dec 14.

Division of Pediatrics, Department of Medicine, Faculty of Medicine, University of Oviedo, CP 33006, Oviedo, Asturias, Spain.

Growth retardation is a major feature of chronic kidney disease (CKD) of onset in infants or children and is associated with increased morbidity and mortality. Several factors have been shown to play a causal role in the growth impairment of CKD. All these factors interfere with growth by disturbing the normal physiology of the growth plate of long bones. Read More

Clin Kidney J 2018 Dec 30;11(6):810-821. Epub 2018 Jul 30.

Infection, Immunity and Inflammation, University of Leicester, Leicester, UK.

Skeletal muscle wasting is a common feature of chronic kidney disease (CKD) and is clinically relevant due to associations with quality of life, physical functioning, mortality and a number of comorbidities. Satellite cells (SCs) are a population of skeletal muscle progenitor cells responsible for accrual and maintenance of muscle mass by providing new nuclei to myofibres. Recent evidence from animal models and human studies indicates CKD may negatively affect SC abundance and function in response to stimuli such as exercise and damage. Read More

Arq Bras Cir Dig 2018 Dec 6;31(4):e1398. Epub 2018 Dec 6.

Program of Post-Graduation in Surgical Clinic of the Federal University of Paraná, Curitiba, PR, Brazil.

Background: Chronic kidney disease affects more than 500 million people worldwide. In this context, the uremic toxins present are related to worsening in tissue healing.

Aim: Evaluate on healing of colonic anastomosis in uremic rats, serum and anatomopathological indicators, which may be related to the change tissue repair process. Read More

Front Physiol 2018 27;9:1692. Epub 2018 Nov 27.

The Wales Kidney Research Unit, Division of Infection and Immunity, School of Medicine, Cardiff University, Cardiff, United Kingdom.

Peritoneal dialysis (PD) is an essential daily life-saving treatment for end-stage renal failure. PD therapy is limited by peritoneal inflammation, which leads to peritoneal membrane failure as a result of progressive fibrosis. Peritoneal infections, with the concomitant acute inflammatory response and membrane fibrosis development, worsen PD patient outcomes. Read More

J Parasit Dis 2018 Dec 19;42(4):630-635. Epub 2018 Oct 19.

4Department of Zoology, Faculty of Science, Damanhour University, Damanhûr, 21634 Egypt.

Patients with chronic renal failure are more susceptible to infections due to acquired immunodeficiency caused by uremia. Parasitic infections are one of the significant causes of morbidity and mortality in those patients, So we aimed to assess the prevalence of spp. and other protozoan infections in patients undergoing hemodialysis in Qena Governorate, Upper Egypt. Read More

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nephrology, Minhang Hospital,Fudan University, Shanghai, China.

Objective: This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia.

Methods: A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and the expression of IL-1β, IL-6, and CRP was determined using enzyme-linked immunosorbent assay. Read More

Afr J Emerg Med 2018 Dec 27;8(4):134-139. Epub 2018 Jul 27.

Department of Medicine, Federal Medical Center, Owo, Nigeria.

Introduction: Late presentation, usually to the emergency centre (EC), is frequently reported among patients with chronic kidney disease (CKD) in resource-limited settings, and is known to be associated with poor outcomes. This study aims to describe the pattern of EC presentation of adults with CKD in Southwest Nigeria.

Methods: This was a prospective observational study of 158 consecutively presenting CKD patients at the EC of two tertiary hospitals in Southwest Nigeria. Read More

Hematology Am Soc Hematol Educ Program 2018 11;2018(1):371-376

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Atypical hemolytic uremic syndrome (aHUS); hemolysis, elevated liver function tests, and low platelets syndrome; and transplant-associated thrombotic microangiopathy are related conditions, in that many patients harbor germline heterozygous mutations in genes that regulate the alternative pathway of complement (APC). Penetrance is variable because development of clinically significant disease appears to require supervention of a process such as inflammation. Complement activation on the endothelial surfaces leads to endothelial damage, platelet consumption, microthrombi, and a mechanical hemolytic anemia with schistocytes. Read More

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

South Med J 2018 Dec;111(12):754-757

From the Hospital Medicine Unit and the Core Educator Faculty and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, the Heart and Vascular Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

We present the case of a 47-year-old man with a history of diabetes mellitus and diabetic nephropathy who was admitted to our hospital with acute uremic myopericarditis. Echocardiography demonstrated a fibrinous pericardial effusion. The patient was initiated on hemodialysis for hyperkalemia, metabolic acidosis, and uremia. Read More

Iran J Med Sci 2018 Nov;43(6):571-580

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: species are ubiquitous and naturally found in lakes, rivers, streams and hot springs, and other water resources. The present study aimed to investigate the prevalence of species in water resources of Iran by a systematic review and meta-analysis.

Methods: In search of papers relevant to the prevalence of in water resources of Iran, the scientific information database in both English and Persian languages was used. Read More

BMC Nephrol 2018 Dec 4;19(1):346. Epub 2018 Dec 4.

Diabetic Kidney Disease Centre, Renal Unit, Barts Health NHS Trust, The Royal London Hospital, Whitechapel Road, London, E1 1BB, UK.

Background: The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research improved therapeutic strategies to combat renal cardiac pathologies. Read More

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Tumor lysis syndrome (TLS) is an acute, life-threatening disease among adults and children that is associated with the initiation of cytoreductive therapy in the treatment of malignancy. A pattern of metabolic derangements occurs as a result of a massive release of intracellular contents into the systemic circulation. Characteristic findings include hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia, and uremia, all of which can lead to cardiac arrhythmia, seizures, renal failure, and sudden death. Read More

Cell Physiol Biochem 2018 27;51(3):1287-1300. Epub 2018 Nov 27.

Hematopathology Department, Biomedical Diagnosis Centre (CDB), Hospital Clinic of Barcelona, Barcelona, Spain.

Background/aims: Accelerated atherosclerosis in chronic kidney disease (CKD) is preceded by endothelial dysfunction (ED), which exhibits a proinflammatory and prothrombotic phenotype and enhanced oxidative stress. In this study, the effect of several compounds with anti-inflammatory and/or antioxidant properties on uremia-induced endothelial dysfunction has been evaluated in an in vitro model.

Methods: Endothelial cells (ECs) were exposed to sera from uremic patients in the absence and presence of the flavonoids apigenin, genistein and quercetin, the antioxidant enzyme mimetics (AEM) ebselen (glutathione peroxidase mimetic), EUK-134 and EUK-118 (both superoxide dismutase mimetics), and the pharmacological drug N-acetylcysteine (NAC). Read More