28,631 results match your criteria Uremia


Influence of colonic dialysis using Gubenxiezhuo on the distribution of gut microflora in uremia rats.

J Cell Physiol 2018 Dec 10. Epub 2018 Dec 10.

Department of Nephrology, Minhang Hospital,Fudan University, Shanghai, China.

Objective: This study aimed to explore the underlying function of Gubenxiezhuo dialysis on the distribution of gut microflora uremia.

Methods: A uremia rat model was constructed, and the morphology of renal tissue was determined using the hematoxylin-eosin (H&E) staining. Moreover, the blood samples were collected and the expression of IL-1β, IL-6, and CRP was determined using enzyme-linked immunosorbent assay. Read More

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December 2018

Chronic kidney disease in the emergency centre: A prospective observational study.

Afr J Emerg Med 2018 Dec 27;8(4):134-139. Epub 2018 Jul 27.

Department of Medicine, Federal Medical Center, Owo, Nigeria.

Introduction: Late presentation, usually to the emergency centre (EC), is frequently reported among patients with chronic kidney disease (CKD) in resource-limited settings, and is known to be associated with poor outcomes. This study aims to describe the pattern of EC presentation of adults with CKD in Southwest Nigeria.

Methods: This was a prospective observational study of 158 consecutively presenting CKD patients at the EC of two tertiary hospitals in Southwest Nigeria. Read More

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December 2018

Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: Presentations, causes and treatment strategies.

Authors:
Sherifa A Hamed

Expert Rev Clin Pharmacol 2018 Dec 2. Epub 2018 Dec 2.

a Department of Neurology and Psychiatry , Assiut University Hospital , Assiut , Egypt.

Introduction: Uremic syndrome of chronic kidney disease (CKD) is a term used to describe clinical, metabolic and hormonal abnormalities associated with progressive kidney failure. It is a rapidly growing public health problem worldwide. Nervous system complications occur in every patient with uremic syndrome of CKD. Read More

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December 2018

Uremic Pericarditis: Distinguishing Features in a Now-Uncommon Clinical Syndrome.

South Med J 2018 Dec;111(12):754-757

From the Hospital Medicine Unit and the Core Educator Faculty and Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, the Heart and Vascular Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

We present the case of a 47-year-old man with a history of diabetes mellitus and diabetic nephropathy who was admitted to our hospital with acute uremic myopericarditis. Echocardiography demonstrated a fibrinous pericardial effusion. The patient was initiated on hemodialysis for hyperkalemia, metabolic acidosis, and uremia. Read More

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December 2018
2 Reads

Prevalence of Species in Water Resources of Iran: A Systematic Review and Meta-Analysis.

Iran J Med Sci 2018 Nov;43(6):571-580

Applied Microbiology Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Background: species are ubiquitous and naturally found in lakes, rivers, streams and hot springs, and other water resources. The present study aimed to investigate the prevalence of species in water resources of Iran by a systematic review and meta-analysis.

Methods: In search of papers relevant to the prevalence of in water resources of Iran, the scientific information database in both English and Persian languages was used. Read More

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November 2018
1 Read

A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strain.

BMC Nephrol 2018 Dec 4;19(1):346. Epub 2018 Dec 4.

Diabetic Kidney Disease Centre, Renal Unit, Barts Health NHS Trust, The Royal London Hospital, Whitechapel Road, London, E1 1BB, UK.

Background: The end stage renal disease population has a 20 fold higher incidence of cardiovascular mortality compared to the overall population. The development of reno-cardiac syndrome in these patients will result in cardiovascular events to be the cause of 50% of fatalities. There is therefore a need to research improved therapeutic strategies to combat renal cardiac pathologies. Read More

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December 2018
6 Reads

Tumor Lysis Syndrome.

Arch Pathol Lab Med 2018 Nov 30. Epub 2018 Nov 30.

From the Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Tumor lysis syndrome (TLS) is an acute, life-threatening disease among adults and children that is associated with the initiation of cytoreductive therapy in the treatment of malignancy. A pattern of metabolic derangements occurs as a result of a massive release of intracellular contents into the systemic circulation. Characteristic findings include hyperuricemia, hyperphosphatemia, hyperkalemia, hypocalcemia, and uremia, all of which can lead to cardiac arrhythmia, seizures, renal failure, and sudden death. Read More

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November 2018

Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease.

Cell Physiol Biochem 2018 Nov 27;51(3):1287-1300. Epub 2018 Nov 27.

Hematopathology Department, Biomedical Diagnosis Centre (CDB), Hospital Clinic of Barcelona, Barcelona, Spain.

Background/aims: Accelerated atherosclerosis in chronic kidney disease (CKD) is preceded by endothelial dysfunction (ED), which exhibits a proinflammatory and prothrombotic phenotype and enhanced oxidative stress. In this study, the effect of several compounds with anti-inflammatory and/or antioxidant properties on uremia-induced endothelial dysfunction has been evaluated in an in vitro model.

Methods: Endothelial cells (ECs) were exposed to sera from uremic patients in the absence and presence of the flavonoids apigenin, genistein and quercetin, the antioxidant enzyme mimetics (AEM) ebselen (glutathione peroxidase mimetic), EUK-134 and EUK-118 (both superoxide dismutase mimetics), and the pharmacological drug N-acetylcysteine (NAC). Read More

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November 2018
4 Reads

Efficacy of linalool to ameliorate uremia induced vascular calcification in wistar rats.

Phytomedicine 2018 Dec 12;51:191-195. Epub 2018 Oct 12.

Department of Biophysics, Panjab University, Chandigarh 160014, India.

Background: Uremia is the condition generally associated with the last stage of chronic kidney disease (CKD) due to highly reduced glomerular filtration rate. Mortality of the patients diagnosed with Uremia generally occurs due to cardiovascular involvement. This occurs due to the transdifferentiation of vascular smooth muscle cells (VSMCs) into osteogenic cells in hyperphosphatemic condition that is associated with kidney failure promoting extra-osseous calcification. Read More

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December 2018
5 Reads

Review of diffuse cortical injury on diffusion-weighted imaging in acutely encephalopathic patients with an acronym: "CRUMPLED".

Eur J Radiol Open 2018 9;5:194-201. Epub 2018 Nov 9.

Department of Radiology, Division of Neuroradiology, University of Minnesota Medical Center, Minneapolis, MN, USA.

Purpose: Acute encephalopathic syndromes can present a diagnostic challenge due to the wide range of possible etiologies, which also can have vastly different outcomes. The presence of diffuse cortical injury (DCI) on diffusion-weighted imaging (DWI) can help narrow the differential diagnosis. The aim of this review is to categorize the range of possible etiologies of DCI into a useful acronym, "CRUMPLED". Read More

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November 2018
5 Reads

MicroRNA-142-3p improves vascular relaxation in uremia.

Atherosclerosis 2018 Nov 10;280:28-36. Epub 2018 Nov 10.

Department of Internal Medicine, Clinical Division of Nephrology, Medical University of Graz, Graz, Austria.

Background And Aims: Chronic kidney disease (CKD) is strongly associated with a high burden of cardiovascular morbidity and mortality. Therefore, we aimed to characterize the putative role of microRNAs (miR)s in uremic vascular remodelling and endothelial dysfunction.

Methods: We investigated the expression pattern of miRs in two independent end-stage renal disease (ESRD) cohorts and in the animal model of uremic DBA/2 mice via quantitative RT-PCR. Read More

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November 2018
4 Reads

Numerical simulations of the microvascular fluid balance with a non-linear model of the lymphatic system.

Microvasc Res 2018 Nov 16;122:101-110. Epub 2018 Nov 16.

LaBS, Chemistry, Material and Chemical Engineering Department "Giulio Natta", Politecnico di Milano, Italy.

Fluid homeostasis is required for life. Processes involved in fluid balance are strongly related to exchanges at the microvascular level. Computational models have been presented in the literature to analyze the microvascular-interstitial interactions. Read More

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November 2018
4 Reads

Use of antiepileptic mood stabilizers in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):756-764. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Several antiepileptic drugs (AEDs) are approved by the US Food and Drug Administration for the treatment of bipolar disorder (valproic acid, divalproex, lamotrigine, carbamazepine) and some cutaneous neuropathic pain syndromes (carbamazepine, gabapentin, pregabalin). The AEDs may be effective in the management of (1) chronic pruritus, including pruritus due systemic disease, including uremia, neuropathic pain, neuropathic pruritus, and complex cutaneous sensory syndromes, especially where central nervous system (CNS) sensitization plays a role; (2) management of emotional dysregulation and the resultant repetitive self-excoriation or other cutaneous self-injury in patients who repetitively stimulate or manipulate their integument to regulate emotions (prurigo nodularis, lichen simplex chronicus, skin picking disorder, trichotillomania); (3) management of dermatologic clinical manifestations associated with autonomic nervous system activation (hyperhidrosis, urticaria, flushing; these often occur in conjunction with psychiatric disorders with prominent autonomic activation and dysregulation, eg, social anxiety disorder, posttraumatic stress disorder); and (4) when certain anticonvulsants have a direct therapeutic effect (eg, in psoriasis); currently the use of AEDs for such cases is largely experimental. Gabapentin (dosage range 300-3600 mg daily) is the most widely studied AED mood stabilizer in dermatology and is especially effective in situations where CNS sensitization is a mediating factor. Read More

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August 2018
5 Reads

Clinical and sero-molecular characterization of with an emphasis on hybrid strain in healthy and diarrheic neonatal calves in Egypt.

Open Vet J 2018 12;8(4):351-359. Epub 2018 Oct 12.

Animal Health Research Institute, Assuit, Egypt.

The present study was carried out to characterize pathogenic in apparently healthy and diarrheic neonatal calves with special reference to the hybrid strains and evaluate their clinical and hematobiochemical consequences. One hundred and seventy calves (age 1-30 days) were divided into two groups: apparently healthy (n = 70) and diarrheic (n=100). Animals were subjected to thorough clinical, hematobiochemical and bacteriological examinations. Read More

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October 2018
5 Reads

Postpartum nephrotic syndrome related to new onset of systemic lupus erythematosus: A case report.

Case Rep Womens Health 2018 Oct 15;20:e00083. Epub 2018 Oct 15.

Second Department of Obstetrics and Gynecology, Aretaieio University Hospital, Vasilissis Sofias 76, Greece.

Postpartum nephrotic syndrome in a pregnant woman with rheumatoid arthritis in long-standing remission is rare. Systemic lupus erythematosus can remain undiagnosed, especially in the absence of clinical manifestations. We present the case of a 34-year-old woman (gravida 2, para 1) who underwent a lower-segment cesarean section at 34 weeks and 6 days of gestation because she had developed preeclampsia and nephrotic syndrome. Read More

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October 2018
6 Reads

Changing Dialysis Modality during Pregnancy: A Case Report.

Perit Dial Int 2018 Nov-Dec;38(6):456-458

Section of Nephrology, Department of Internal Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

Pregnancy in patients with end-stage renal disease is rare, with a paucity of management guidelines in the literature. Various hemodialysis (HD) and peritoneal dialysis (PD) protocols have been used to successfully manage pregnancy in this population; however, there is a growing body of evidence that the best maternal and fetal outcomes are associated with intensified, high-dose HD. The optimal timing of transition from PD to HD is not known for prevalent PD patients who become pregnant. Read More

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November 2018
1 Read

Cardiovascular Disease in Children and Adolescents With Chronic Kidney Disease.

Semin Nephrol 2018 Nov;38(6):559-569

Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. Electronic address:

The lifespan of children with advanced chronic kidney disease (CKD), although improved over the past 2 decades, remains low compared with the general pediatric population. Similar to adults with CKD, cardiovascular disease accounts for a majority of deaths in children with CKD because these patients have a high prevalence of traditional and uremia-related risk factors for cardiovascular disease. The cardiovascular alterations that cause these terminal events begin early in pediatric CKD. Read More

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November 2018
1 Read

Two-dimensional speckle tracking to image ventricular-arterial coupling in uremia.

Echocardiography 2018 Nov 8. Epub 2018 Nov 8.

Department of Ultrasound, The People's Hospital of Gaozhou City, Gaozhou, Guangdong, China.

Objective: To study ventricular-arterial coupling(VAC) in uremic patients by application of two-dimensional speckle tracing imaging (2DSTI).

Methods: One hundred uremic patients were divided into two groups based on left ventricular ejection fraction (LVEF): group 1 with LVEF ≥ 5%, and group 2 with LVEF < 55%. Forty healthy subjects were recruited as a control group. Read More

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November 2018
4 Reads

Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients.

Mediators Inflamm 2018 15;2018:1347432. Epub 2018 Oct 15.

Department of Biomedical Sciences for Health, Laboratory of Clinical Pathology, Università degli Studi di Milano, Milan, Italy.

End-stage renal disease patients on dialysis (CKD-G5D) have a high mortality rate due to cardiovascular diseases (CVD). In these patients, inflammation, oxidative stress, and uremia increase the production of glycation products (AGEs) which in turn accelerate CVD onset and progression. Recently, attention has been given to the soluble receptor for AGEs (sRAGE) as a marker of inflammation, oxidative stress, atherosclerosis, and heart failure in CKD-G5D. Read More

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October 2018
5 Reads

Emphysematous pyelonephritis and cystitis in a patient with uremia and anuria: A case report and literature review.

Medicine (Baltimore) 2018 Nov;97(45):e11272

Department of Nephrology, Qilu Hospital of Shandong University (Qingdao).

Introduction: Emphysematous pyelonephritis (EPN) or cystitis (EC) is a severe infection of the urinary tract with high mortality. EPN is uncommon among the patients of end stage of renal failure (ESRD) CASE PRESENTATION:: A 38-year-old male with uremia and anuria who was on hemodialysis was found to have gas formation in the bilateral pelvis, ureters, and urinary bladder by CT scan. The diagnosis was emphysematous pyelonephritis and cystitis. Read More

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November 2018
20 Reads

Serum and Lipoprotein Particle miRNA Profile in Uremia Patients.

Genes (Basel) 2018 Nov 5;9(11). Epub 2018 Nov 5.

University of Applied Sciences Upper Austria, School of Medical Engineering and Applied Social Sciences, 4020 Linz, Austria.

microRNAs (miRNAs) are post-transcriptional regulators of messenger RNA (mRNA), and transported through the whole organism by-but not limited to-lipoprotein particles. Here, we address the miRNA profile in serum and lipoprotein particles of healthy individuals in comparison with patients with uremia. Moreover, we quantitatively determined the cellular lipoprotein-particle-uptake dependence on the density of lipoprotein particle receptors and present a method for enhancement of the transfer efficiency. Read More

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November 2018
5 Reads

Vegetarian diet may ameliorate uremic pruritus in hemodialysis patients.

Ren Fail 2018 Nov;40(1):514-519

g Division of Nephrology , Asia University Hospital , Taichung , Taiwan.

Objectives: Systemic inflammation has been reported to be associated with uremic pruritus (UP). Although a vegetarian diet can reduce systemic inflammation in hemodialysis patients, the effect of vegetarian diet on UP is not clear. The purpose of the study was to know the possible effects of vegetarian diet on UP. Read More

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November 2018
5 Reads

Non-invasive quantification of malondialdehyde biomarker in human exhaled breath condensate using self-assembled organic-inorganic nanohybrid: A new platform for early diagnosis of lung disease.

J Pharm Biomed Anal 2018 Oct 29;164:249-257. Epub 2018 Oct 29.

Department of Nanochemistry, Nano Technology Research Center, Uremia University, Uremia, 57154, Iran.

A novel electrochemical sensor was developed towards recognition of malondialdehyde (MDA) with modifying the glassy carbon electrode (GCE) by self-assembled riboflavin-taurine (RFPT) as organic substrate and silver nanoparticle (Ag NPs) as inorganic nano-catalyst. Therefore, a novel biocompatible and anti-bacterial substrate were prepared for the construction of electrode. In proposed sensor, the RF-PT polymer film led to the emergence of electroactive and suitable substrate for the immobilization of Ag NPs. Read More

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October 2018
5 Reads
2.980 Impact Factor

Nutritional Considerations in Preventing Muscle Atrophy.

Adv Exp Med Biol 2018 ;1088:497-528

Division of Food Hygiene and Ecology, Faculty of Nursing and Midwifery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.

Muscle atrophy may occur under different circumstances throughout a person's life. These conditions include periods of immobilization of a limb or of the whole body and aging accompanied by the onset of sarcopenia. Muscle mass is reduced as a result of decreased protein synthesis or increased protein degradation. Read More

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January 2018
2 Reads

Symptom Cluster Science in Chronic Kidney Disease: A Literature Review.

West J Nurs Res 2018 Oct 31:193945918808766. Epub 2018 Oct 31.

1 College of Nursing, The University of Illinois at Chicago, IL, USA.

The purpose of this review was to synthesize evidence on symptom clusters in patients with chronic kidney disease (CKD). The quality of studies was evaluated using the Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies. Twelve articles met inclusion criteria. Read More

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October 2018
1 Read

Vitamin D Attenuates Endothelial Dysfunction in Uremic Rats and Maintains Human Endothelial Stability.

J Am Heart Assoc 2018 Sep;7(17):e008776

1 Department of Nephrology VU University Medical Center Amsterdam The Netherlands.

Background Dysfunctional endothelium may contribute to the development of cardiovascular complications in chronic kidney disease ( CKD ). Supplementation with active vitamin D has been proposed to have vasoprotective potential in CKD , not only by direct effects on the endothelium but also by an increment of α-Klotho. Here, we explored the capacity of the active vitamin D analogue paricalcitol to protect against uremia-induced endothelial damage and the extent to which this was dependent on increased α-Klotho concentrations. Read More

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September 2018
4 Reads

Hemodialysis reinitiation using a resurrected mummy fistula: a case report.

BMC Nephrol 2018 Oct 26;19(1):296. Epub 2018 Oct 26.

Department of Ultrasonography, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, 400016, China.

Background: Kidney allograft loss becomes an important cause of end-stage kidney disease and requires dialysis reinitiation. We report a case of a patient who restarted hemodialysis after his second kidney graft failure using a long-discarded autologous arteriovenous fistula.

Case Presentation: A 62-year-old man was diagnosed with end-stage renal disease 20 year ago, and a native arteriovenous fistula was created for hemodialysis. Read More

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October 2018
4 Reads

Priority for Treatment and Intensive Care of Patients With Non-Severe Community-Acquired Pneumonia.

Am J Med Sci 2018 Oct 7;356(4):329-334. Epub 2018 Aug 7.

Guangzhou Institute of Respiratory Diseases (State Key Laboratory of Respiratory Diseases), First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.

Background: The Infectious Disease Society of America/the American Thoracic Society (IDSA/ATS) minor criteria for severe community-acquired pneumonia (CAP) are of unequal weight in predicting mortality. It is unclear whether the patients with non-severe CAP meeting the minor criteria most strongly associated to mortality should have the priority for treatment and intensive care. It is warranted to explore this intriguing hypothesis. Read More

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October 2018
5 Reads

Protein Carbamylation in Chronic Kidney Disease and Dialysis.

Adv Clin Chem 2018 23;87:37-67. Epub 2018 Aug 23.

Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States.

Protein carbamylation is a nonenzymatic posttranslational protein modification that can be driven, in part, by exposure to urea's dissociation product, cyanate. In humans, when kidney function is impaired and urea accumulates, systemic protein carbamylation levels increase. Additional mediators of protein carbamylation have been identified including inflammation, diet, smoking, circulating free amino acid levels, and environmental exposures. Read More

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August 2018
8 Reads

Contribution of uraemic toxins to the vascular fibrosis associated with chronic kidney disease.

Nefrologia 2018 Nov - Dec;38(6):639-646. Epub 2018 Oct 15.

Departamento de Biología de Sistemas, Universidad de Alcalá, Alcalá de Henares, Madrid, España; Fundación Renal Íñigo Álvarez de Toledo (FRIAT), Madrid, España; Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), Madrid, España; Red de Investigación Renal (REDinREN), Instituto de Salud Carlos III, Madrid, España. Electronic address:

Background: Patients with chronic kidney disease present with an accumulation of uraemic toxins, which have been identified as pathogenic agents associated with cardiovascular mortality, which is very high is this patient group. A phenomenon common to the progressive renal dysfunction and associated vascular damage, is the abnormal accumulation of extracellular matrix (ECM) proteins in the renal or vascular structures.

Objective: To determine the contribution of uraemia or the uraemic toxins to the production of cytokinins and ECM in aortas of uraemic animals or human aortic smooth muscle cells (HASMCs). Read More

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October 2018
6 Reads

Homocysteine Aggravates Intestinal Epithelial Barrier Dysfunction in Rats with Experimental Uremia.

Kidney Blood Press Res 2018 18;43(5):1516-1528. Epub 2018 Oct 18.

Background/aims: Previous studies have shown that homocysteine (Hcy) is an important intestinal-derived uremic toxin. However, whether Hcy is involved in the epithelial barrier dysfunction observed in uremia remains unclear. This study aimed to investigate the effect of Hcy on intestinal permeability and intestinal barrier structure and function in adenine-induced uremic rats. Read More

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October 2018
5 Reads

Circulating miR-421 Targeting Leucocytic Angiotensin Converting Enzyme 2 Is Elevated in Patients with Chronic Kidney Disease.

Nephron 2018 Oct 16:1-14. Epub 2018 Oct 16.

Department of Internal Medicine II, Martin Luther University Halle-Wittenberg, Halle, Germany.

Background: Decreased levels of leucocytic angiotensin converting enzyme 2 (ACE2) relate to atherosclerosis in patients with chronic kidney disease (CKD). Recently, micro RNA 421 (miR-421) was found to target and down-regulate ACE2 in human cardiac myofibroblasts. In this study, we investigated the correlation between serum levels of miR-421 and ACE2 transcripts in circulating leukocytes of healthy individuals (NP), CKD (3-5) and haemodialysis (HD) patients. Read More

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October 2018
4 Reads

Fluid Management With Peritoneal Dialysis After Pediatric Cardiac Surgery.

World J Pediatr Congenit Heart Surg 2018 11;9(6):696-704

2 Department of Pediatrics, School of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.

Children who undergo cardiac surgery with cardiopulmonary bypass are a unique population at high risk for postoperative acute kidney injury (AKI) and fluid overload. Fluid management is important in the postoperative care of these children as fluid overload is associated with increased morbidity and mortality. Peritoneal dialysis catheters are an important tool in the armamentarium of a cardiac intensivist and are used for passive drainage for fluid removal or dialysis for electrolyte and uremia control in AKI. Read More

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November 2018
1 Read

Determination of urea with special emphasis on biosensors: A review.

Biosens Bioelectron 2019 Jan 20;123:36-50. Epub 2018 Sep 20.

Department of Biochemistry, M.D. University, Rohtak 124001, Haryana, India.

Urea is the major end product of nitrogen metabolism in humans, which is eliminated from the body mainly by the kidneys through urine but is also secreted in body fluids such as blood and saliva. Its level in urine ranges from 7 to 20 mg/dL, which drastically rises under patho-physiological conditions thus providing key information of renal function and diagnosis of various kidney and liver disorders. Increase in urea levels in blood, also referred to as azotemia or uremia. Read More

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January 2019
2 Reads

Uremia Impacts VE-Cadherin and ZO-1 Expression in Human Endothelial Cell-to-Cell Junctions.

Toxins (Basel) 2018 Oct 7;10(10). Epub 2018 Oct 7.

Experimental Nephrology Laboratory, Basic Pathology Department, Universidade Federal do Paraná, Curitiba 80050-540, Brazil.

Endothelial dysfunction in uremia can result in cell-to-cell junction loss and increased permeability, contributing to cardiovascular diseases (CVD) development. This study evaluated the impact of the uremic milieu on endothelial morphology and cell junction's proteins. We evaluated (i) serum levels of inflammatory biomarkers in a cohort of chronic kidney disease (CKD) patients and the expression of VE-cadherin and Zonula Occludens-1 (ZO-1) junction proteins on endothelial cells (ECs) of arteries removed from CKD patients during renal transplant; (ii) ECs morphology in vitro under different uremic conditions, and (iii) the impact of uremic toxins p-cresyl sulfate (PCS), indoxyl sulfate (IS), and inorganic phosphate (Pi) as well as of total uremic serum on VE-cadherin and ZO-1 gene and protein expression in cultured ECs. Read More

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October 2018
6 Reads

The relationship between autophagy, increased neutrophil extracellular traps formation and endothelial dysfunction in chronic kidney disease.

Clin Immunol 2018 Dec 6;197:189-197. Epub 2018 Oct 6.

Department of Internal Medicine & Kidney Research Institute, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Department of Clinical Immunology, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea. Electronic address:

In chronic kidney disease (CKD), the number of circulating neutrophils are increased, and this is usually accompanied by an increased basal activation state. However, the possible association between neutrophil extracellular traps (NETs) with vascular complications has not been evaluated. We assessed the relationship between NETs, autophagy and endothelial dysfunction in maintenance hemodialysis (MHD) patients. Read More

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December 2018
5 Reads

Choosing a dialyzer: What clinicians need to know.

Hemodial Int 2018 Oct 8. Epub 2018 Oct 8.

UCL Centre for Nephrology, Royal Free Hospital, University College London, London, UK.

The objectives of hemodialysis have moved from the diffusive clearance of small molecular weight uremic toxins and achieving dialyzer urea adequacy targets to emphasis on improving clinical outcomes in end stage renal failure patients by increasing larger sized uremic toxin clearance. Clinical emphasis in the last few decades has focused on increasing middle molecule weight toxin clearance by hemodiafiltration. Although long-term data is still lacking, short-term outcomes appear promising. Read More

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October 2018
4 Reads

[Clinicopathologic features of lipoprotein glomerulopathy: observation of 6 cases].

Zhonghua Yi Xue Za Zhi 2018 Sep;98(36):2910-2913

Division of Nephrology, China-Japan Friendship Hospital, Beijing 100029, China.

To investigate the clinicopathologic features of lipoprotein glomerulopathy (LPG). A total of 6 cases (5 males and 1 female, with a mean age of 27.5 years and age range of 11-53 years) of lipoprotein glomerulopathy with complete clinicopathologic data were enrolled. Read More

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September 2018
2 Reads

Nonrheumatoid Fibrinous Pericarditis: A Medical Examiner Algorithm for the Diagnosis of Viral Myocarditis and Use of Molecular Diagnostic Techniques.

Am J Forensic Med Pathol 2018 Oct 2. Epub 2018 Oct 2.

Department of Pathology, University of Michigan, Ann Arbor, MI.

Classic "bread-and-butter" appearance of fibrinous pericarditis had been described in rheumatic disease and other immunologic diseases such as systemic lupus erythematosus, post-myocardial infarct, uremia, tuberculosis, radiation effects, bacterial, and viral etiology. In most of the described cases, pericarditis occurs as a delayed complication. We present a case of a 21-year-old white woman who was seen in the emergency department to rule out pulmonary embolism for shortness of breath, chest pain, and lightheadedness. Read More

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October 2018
1 Read

Membrane innovation: closer to native kidneys.

Nephrol Dial Transplant 2018 Oct;33(suppl_3):iii22-iii27

Nelson, New Zealand.

Modern methods in analytical biochemistry have established that uraemia is associated with the retention of proteins, both in their native state and post-translationally modified, over a wide range of molecular weights up to 60 kDa. Evidence is accumulating that these higher molecular weight retention solutes are important uraemic toxins, and therapies such as online haemodiafiltration (HDF), which enhance their removal, are associated with improved outcomes. However, HDF has limitations regarding cost, clinical implementation and the need for an external source of sterile substitution solution to maintain fluid balance. Read More

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October 2018
4 Reads

Increased electronegativity of high-density lipoprotein in uremia patients impairs its functional properties and is associated with the risk of coronary artery disease.

Atherosclerosis 2018 Nov 13;278:147-155. Epub 2018 Sep 13.

Medical Research, China Medical University Hospital, 2 Yu-Der Rd, Taichung, 40447, Taiwan; Proteomic Core Laboratory, China Medical University Hospital, 2 Yu-Der Rd, Taichung, 40447, Taiwan; Graduate Institute of Integrated Medicine, China Medical University, No 91, Hsueh-Shih Rd, Taichung, 40402, Taiwan. Electronic address:

Background And Aims: Uremia patients have impaired high-density lipoprotein (HDL) function and a high risk of coronary artery disease (CAD). Increased lipoprotein electronegativity can compromise lipoprotein function, but the effect of increased HDL electronegativity on HDL function and its association with CAD in uremia patient are not clear. We aimed to assess HDL electronegativity and various properties of HDL in uremia patients and investigate whether electronegative HDL is a risk factor for CAD in these individuals. Read More

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November 2018
2 Reads

Beraprost sodium versus clopidogrel for preventing vascular thromboembolic events of arteriovenous fistula in uraemic patients: a retrospective study with a mean 3-year follow-up.

J Int Med Res 2018 Oct 1:300060518800517. Epub 2018 Oct 1.

9 Department of Orthopaedics, Jinshan Hospital, Fudan University, Jinshan District, Shanghai City, China.

Objective This study aimed to evaluate the efficacy of beraprost sodium (BPS) or clopidogrel (CL) using vascular thromboembolic events (VTEs) of arteriovenous fistula as a primary endpoint in patients with end-stage renal disease (ESRD) undergoing arteriovenous fistula surgery. Methods We performed a multicentre, retrospective cohort study from August 2012 to August 2016. We studied patients with ESRD who underwent arteriovenous fistula surgery and received peroral administration of 40 µg BPS, three times per day, for 1 month, or 75 mg CL (initial dose of 300 mg), one time per day, for 1 month. Read More

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October 2018
14 Reads
1.090 Impact Factor

Role of Different Blood Purification Nursing Models in Uremic Patients: A Preliminary Report.

Med Sci Monit 2018 Sep 28;24:6873-6881. Epub 2018 Sep 28.

Department of Nephrology, Center of Blood Purification, The Second People's Hospital of Nantong, Nantong, Jiangsu, China (mainland).

BACKGROUND Accumulation of uremic toxins is closely associated with chronic kidney disease (CKD)-related complications such as cerebrovascular accidents and cardiovascular diseases. Clinical nursing is accepted as a critical clinical prognosis factor for hospitalized patients. The present study was designed to compare the effects of different blood purification nursing models on clinical outcomes in patients with uremia. Read More

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September 2018
1 Read

A New Series of Sorbent Devices for Multiple Clinical Purposes: Current Evidence and Future Directions.

Blood Purif 2018 Sep 25:1-7. Epub 2018 Sep 25.

IRRIV, International Renal Research Institute Vicenza, Vicenza, Italy.

Adsorption is an extracorporeal technique utilized for blood purification. It complements convection and diffusion (the main modalities of solute removal). It involves the passage of blood (or plasma) through an adsorption cartridge, where solutes are removed by direct binding to the sorbent material. Read More

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September 2018
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Complement activation is associated with more severe course of diarrhea-associated hemolytic uremic syndrome, a preliminary study.

Eur J Pediatr 2018 Dec 24;177(12):1837-1844. Epub 2018 Sep 24.

Department of Pediatrics, 2nd Faculty of Medicine, Charles University in Prague and University Hospital Motol, Prague, Czech Republic.

Diarrhea-associated hemolytic uremic syndrome is characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury secondary to enteric infection, typically Shiga toxin-producing Escherichia coli. Shiga toxin 2 is able to activate alternative complement pathways; therefore, the aim of the study was to analyze C3 as a predictor of clinical courses in patients with diarrhea-associated hemolytic uremic syndrome. We hypothesized that the patients with increased complement activation at admission suffered from a more severe course. Read More

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December 2018
2 Reads
1.983 Impact Factor

Regional citrate anticoagulation for continuous renal replacement therapy.

Curr Opin Crit Care 2018 Dec;24(6):450-454

Department of Anesthesiology, University Hospital Duesseldorf, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany.

Purpose Of Review: The delivery of an effective dialysis dose in continuous renal replacement therapy (CRRT) depends on adequate anticoagulation of the extracorporeal circuit. In most patients, either systemic heparin anticoagulation (SHA) or regional citrate anticoagulation (RCA) is used. This review will outline the basics and rationale of RCA and summarize data on safety and efficacy of both techniques. Read More

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December 2018
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Hypoxic, Toxic, and Acquired Metabolic Encephalopathies at the Emergency Room: The Role of Magnetic Resonance Imaging.

Semin Ultrasound CT MR 2018 Oct 12;39(5):481-494. Epub 2018 Mar 12.

CDPI/DASA-Clínica de Diagnóstico por Imagem/Diagnósticos da America, Rio de Janeiro, Brazil; CDPI/DASA, Americas Medical City, Rio de Janeiro, Brazil.

Our purpose is to describe typical computed tomography and magnetic resonance imaging findings in encephalopathies in the emergency. The focus of this article are the most frequent toxic and acquired metabolic diseases and their preferential sites of involvement, such as hepatic encephalopathy, hypoglicemia, nonketotic hyperglycemia, osmotic demyelination, posterior reversible encephalopathy syndrome, uremia, illegal drug abuse, carbon monoxide poisoning, and hypoxic-ischemic encephalopathy. The radiologist must be able to identify the most usual patterns of lesion in computed tomography and magnetic resonance imaging in these settings. Read More

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October 2018
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CRRT for sepsis-induced acute kidney injury.

Curr Opin Crit Care 2018 Dec;24(6):483-492

Department of Nephrology, Dialysis and Transplantation, San Bortolo Hospital.

Purpose Of Review: Sepsis-induced acute kidney injury (SI-AKI) represents the first cause of AKI in ICUs, and renal replacement therapy (RRT) is frequently applied in advanced AKI stages. The debate between 'rescue' indications for RRT start in patients with severe AKI (acidosis, hyperkalemia, uremia, oliguria/anuria, volume overload) and a proactive RRT initiation is still ongoing. In addition, current SI-AKI pathophysiologic theory has identified the toxic effects of soluble middle-molecules released during sepsis and inflammation (pathogen and damaged associated molecular patterns). Read More

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December 2018
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Hemodialysis-related changes in phenotypical features of monocytes.

Sci Rep 2018 Sep 18;8(1):13964. Epub 2018 Sep 18.

Clinic of Nephrology and Hypertension, Diabetes and Endocrinology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany.

Hemodialysis (HD) patients exhibit chronic inflammation and leukocyte activation. We investigated the surface-marker profile of monocytes by flow cytometry to assess the chronic effect of uremia and the acute effect of dialysis on their phenotypical and functional features in 16 healthy controls (CON) and 15 HD patients before and after a polysulfone-based dialysis session. Median fluorescence intensities were analyzed indicating expression of CD14, CD16, integrins (CD11b, CD18), chemokine receptors (CCR2, CX3CR1), scavenger receptors (CD36, CD163) and Toll-like receptor-2 (TLR2). Read More

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September 2018
5 Reads

Uraemia-induced immune senescence and clinical outcomes in chronic kidney disease patients.

Nephrol Dial Transplant 2018 Sep 6. Epub 2018 Sep 6.

INSERM, UMR1098, Federation Hospitalo-Universitaire, INCREASE, Besançon, France.

Background: Patients with chronic kidney disease (CKD) are more prone to develop premature age-related diseases. Data on immune senescence are scarce in CKD populations, except in end-stage renal disease and dialysis. We designed a longitudinal prospective study to evaluate immune senescence at different CKD stages and its influence on CKD patient outcomes. Read More

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September 2018
2 Reads