2,371 results match your criteria Ureaplasma Infection


Ureaplasma diversum protein interaction networks: evidence of horizontal gene transfer and evolution of reduced genomes among the Mollicutes.

Can J Microbiol 2019 Apr 24. Epub 2019 Apr 24.

Universidade Federal da Paraiba, 28097, Molecular Biology , Cidade Universitária, Campus I , João Pessoa , Joao Pessoa, Brazil , 58051-900 ;

Ureaplasma diversum is a member of the Mollicutes class and causes urogenital tract infection in cattle and small ruminants. Studies indicate that the process of horizontal gene transfer, the exchange of genetic material among different species, has a crucial role in mollicute evolution, affecting the group's characteristic genomic reduction process and simplification of metabolic pathways. Using bioinformatics tools and the String database of known and predicted protein interactions, we constructed the protein-protein interaction network of U. Read More

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http://dx.doi.org/10.1139/cjm-2018-0688DOI Listing

Predominance of cervicitis agents with minimal testing rate within the student population in Benin city, Nigeria.

J Obstet Gynaecol 2019 Apr 22:1-5. Epub 2019 Apr 22.

c Department of Obstetrics and Gynaecology , Nnamdi Azikiwe University Teaching Hospital , Nnewi , Nigeria.

Here, we aimed to investigate the predominance of cervicitis agents with minimal testing rates among asymptomatic students in a Tertiary Institution and its associated risk factors. Endocervical swabs were collected from randomly selected 133 female students (15-34 years of age) in Benin City, Nigeria and screened for six genital pathogens (Chlamydia trachomatis, Mycoplasma hominis, M. genitalium, Ureaplasma urealyticum, U. Read More

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http://dx.doi.org/10.1080/01443615.2019.1584888DOI Listing

Genital tract infection and associated factors affect the reproductive outcome in fertile females and females undergoing fertilization.

Biomed Rep 2019 Apr 15;10(4):231-237. Epub 2019 Feb 15.

Department of Microbiology, 'Aretaieion' General Hospital, National and Kapodistrian University of Athens, Athens 11528, Greece.

Assisted reproductive techniques including fertilization (IVF) are being used increasingly worldwide and screening for genital tract infections (GTIs) is recommended prior to treatment as their presence may affect the success rate of IVF. The current study aimed to assess the possible associations between GTI-associated factors and reproductive outcome in a group of reproductive age fertile females and infertile females receiving IVF. A total of 111 infertile women enrolled in an IVF programme (Group A) and 104 fertile women (mothers of at least one child; Group B) underwent microbiological screening of vaginal and cervical samples. Read More

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http://dx.doi.org/10.3892/br.2019.1194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439431PMC
April 2019
1 Read

Surveillance for incidence and etiology of early-onset neonatal sepsis in Soweto, South Africa.

PLoS One 2019 10;14(4):e0214077. Epub 2019 Apr 10.

Medical Research Council: Respiratory and Meningeal Pathogens Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Globally, over 400,000 neonatal deaths in 2015 were attributed to sepsis, however, the incidence and etiologies of these infections are largely unknown in low-middle income countries. We aimed to determine incidence and etiology of community-acquired early-onset (<72 hours age) sepsis (EOS) using culture and molecular diagnostics.

Methods: This was a prospective observational study, in which we conducted a surveillance for pathogens using a combination of blood culture and a polymerase chain reaction (PCR)-based test. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214077PLOS
April 2019
6 Reads

Antibiotic administration can eradicate intra-amniotic infection or inflammation in a subset of patients with preterm labor and intact membranes.

Am J Obstet Gynecol 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam-si, Korea.

Background: Intra-amniotic infection is present in 10% of patients with an episode of preterm labor, and is a risk factor for impending preterm delivery and neonatal morbidity/mortality. Intra-amniotic inflammation is often associated with intra-amniotic infection, but sometimes is present in the absence of detectable microorganisms. Antibiotic treatment of intra-amniotic infection has traditionally been considered to be ineffective. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.018DOI Listing
March 2019
2 Reads

Evidence that antibiotic administration is effective in the treatment of a subset of patients with intra-amniotic infection/inflammation presenting with cervical insufficiency.

Am J Obstet Gynecol 2019 Mar 27. Epub 2019 Mar 27.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. Electronic address:

Background: Cervical insufficiency is a risk factor for spontaneous midtrimester abortion or early preterm birth. Intra-amniotic infection has been reported in 8-52% of such patients, and intra-amniotic inflammation in 81%. Some professional organizations have recommended perioperative antibiotic treatment when emergency cervical cerclage is performed. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.03.017DOI Listing
March 2019
3 Reads

Positive culture rate and antimicrobial susceptibilities of and .

Obstet Gynecol Sci 2019 Mar 13;62(2):127-133. Epub 2019 Feb 13.

Department of Obstetrics and Gynecology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

Objective: To assess positive culture rate and antimicrobial susceptibilities of (MH) and (UU) in symptomatic general population and pregnant women admitted with preterm labor and premature rupture of membranes.

Methods: We retrospectively reviewed medical records of patients who have undergone culture test and antimicrobial susceptibilities at our center from January 2017 to April 2018. Patients with positive culture for MH, UU, or both were included in this study. Read More

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http://dx.doi.org/10.5468/ogs.2019.62.2.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422850PMC
March 2019
5 Reads

Performance Evaluation of a New Culture Colorimetric Detection Assay.

Eurasian J Med 2019 Feb 30;51(1):5-7. Epub 2018 Nov 30.

Department of Clinical Microbiology and Virology, Polyclinic Tor Vergata Foundation, Rome, Italy.

Objective: To evaluate the performance of the culture colorimetric detection assay MYCO WELL D-ONE (MWD-ONE), designed to detect sexually transmitted infections using real-time polymerase chain reaction (PCR) as a reference method.

Materials And Methods: One hundred and ten urogenital samples were screened for (GV), (TV), (MH), , and (UU)/ (UP) using the MWD-ONE and real-time PCR assays species Real-TM Quant and Anyplex II STI-7 Detection, respectively.

Results: GV was detected in 33 samples by both the MWD-ONE and real-time PCR, while 6 samples gave discordant results. Read More

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http://dx.doi.org/10.5152/eurasianjmed.2018.17364DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422620PMC
February 2019
1 Read

Emerging role for Ureaplasma parvum serovar 3: Active infection in women with silent high-risk human papillomavirus and in women with idiopathic infertility.

J Cell Physiol 2019 Mar 18. Epub 2019 Mar 18.

Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste, Italy.

Recently, there are controversial opinions on the presence of Mycoplasmas/Ureaplasmas as colonizers or pathogens, and on the use of a targeted therapy. This study aimed to characterize Mycoplasmas/Ureaplasmas infections in reproductive age women, including the acquisition of sexually transmitted (ST) pathogens and poor birth outcomes. A total of 646 healthy Italian women fulfilled the inclusion criteria including 521 infertile women, 65 pregnant women, and 60 fertile women with identified risk factors and symptomatic for vaginitis/cervicitis. Read More

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http://dx.doi.org/10.1002/jcp.28423DOI Listing
March 2019
4 Reads

Mollicutes antibiotic resistance profile and presence of genital abnormalities in couples attending an infertility clinic.

J Int Med Res 2019 Feb 28:300060519828945. Epub 2019 Feb 28.

1 Laboratorio de Metabolismo Experimental e Investigación Clínica; División de Investigación Clínica y Coordinación de Investigación, C.M.N. "20 de Noviembre", ISSSTE, San Lorenzo, Colonia del Valle Sur, Alcaldía Benito Juárez, C.P., Ciudad de México, México.

Objective: The present study aimed to identify Mollicutes infection in the reproductive system. We also examined the microbiological, biochemical, and antimicrobial profiles of Mollicutes infection, which are potentially associated with clinical reproductive abnormalities causing infertility in couples.

Methods: Thirty-seven couples who were attending an infertility clinic were enrolled. Read More

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http://dx.doi.org/10.1177/0300060519828945DOI Listing
February 2019
13 Reads

Roles of Species in Idiopathic Chronic Prostatitis: A Case-Control Study.

World J Mens Health 2019 Feb 12. Epub 2019 Feb 12.

Department of Urology, Dankook University College of Medicine, Cheonan, Korea.

Purpose: Because of the inconsistent symptoms associated with infections, their clinical significances in genitourinary tracts are under debate. Therefore, we evaluated the presence of (UU) and (UP) in urine samples and examined their associations with chronic prostatitis (CP) through a case and control study.

Materials And Methods: We included 696 nonchlamydial nongonococcal (NCNG) urine samples from men; 350 were categorized into non-inflammatory CP, 88 in inflammatory CP, and 258 in non-CP group. Read More

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http://dx.doi.org/10.5534/wjmh.180081DOI Listing
February 2019

Which sample for the transport of mycoplasma, eSwab® or dry swab?

Ann Biol Clin (Paris) 2019 02;77(1):95-98

Laboratoire de virologie, Institut des agents infectieux (IAI) de Lyon, Centre de biologie et de pathologie Nord, Groupement hospitalier Nord, Centre hospitalier universitaire de Lyon, Lyon, France.

Mycoplasma hominis (MH) and Ureaplasma urealyticum (UU), belonging to mycoplasmas, are implicated in genital and urinary infections. These bacteria are extremely sensitive to environmental factors but remain detectable by culture methods. This study aimed to compare performance of detection on samples performed on eSwab or dry swabs. Read More

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http://dx.doi.org/10.1684/abc.2018.1407DOI Listing
February 2019
1 Read

A novel quantitative polymerase chain reaction to monitor urinary tract mycoplasma infection in a dog.

Lett Appl Microbiol 2019 May 19;68(5):409-414. Epub 2019 Mar 19.

School of Animal and Veterinary Science, The University of Adelaide, Adelaide, SA, Australia.

The aim of the study was to develop a quantitative real-time PCR assay for diagnosis and monitoring of mycoplasma urinary tract infections (UTI) in a dog. An English Cocker Spaniel dog with the history of urinary tract infection was physically examined and laboratory findings identified chronic renal insufficiency and urinary tract infection. Attempts to culture organisms from pyuric urine failed, and empirical antibiotic therapy did not resolve the pyuria. Read More

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http://dx.doi.org/10.1111/lam.13139DOI Listing
May 2019
1 Read
1.659 Impact Factor

Hyperammonemia From Ureaplasma Infection in an Immunocompromised Child.

J Pediatr Hematol Oncol 2019 Feb 15. Epub 2019 Feb 15.

Miller Children's and Women's Hospital Long Beach.

Idiopathic hyperammonemia is a rare, poorly understood, and often lethal condition that has been described in immunocompromised patients. This report describes an immunocompromised patient with acute myelogenous leukemia who developed persistent hyperammonemia up to 705 µmol/L (normal, 0 to 47 µmol/L) refractory to multiple different therapies. However, after beginning azithromycin and then doxycycline therapy for Ureaplasma species infection, the patient showed immediate and sustained clinical improvement and resolution of ammonia levels. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001414DOI Listing
February 2019

Comparison of two identification and susceptibility test kits for Ureaplasma spp and Mycoplasma hominis in amniotic fluid of patients at high risk for intra-amniotic infection.

J Matern Fetal Neonatal Med 2019 Feb 20:1-9. Epub 2019 Feb 20.

e Obstetrical Intensive Care Unit, Maternal-Infant Department , Fundación Valle del Lili , Cali , Colombia.

Objective: Ureaplasma urealyticum and Mycoplasma hominis are the most common microorganisms found in the amniotic fluid of patients at risk for preterm delivery. However, culture techniques for genital mycoplasms require special conditions, are barely considered as part of the evaluation of suspected intra-amniotic infection (IAI) and the results are available within 2 and 7 days. The objectives of this study are to validate the use of two commercially available kits (Mycoplasma IES y MYCOFAST RevolutioN) for the identification of Ureaplasma spp. Read More

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http://dx.doi.org/10.1080/14767058.2019.1572742DOI Listing
February 2019
1 Read

More than just inflammation: Ureaplasma species induce apoptosis in human brain microvascular endothelial cells.

J Neuroinflammation 2019 Feb 14;16(1):38. Epub 2019 Feb 14.

University Children's Hospital, University of Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

Background: Ureaplasma species (spp.) are commonly regarded as low-virulent commensals but may cause invasive diseases in immunocompromised adults and in neonates, including neonatal meningitis. The interactions of Ureaplasma spp. Read More

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http://dx.doi.org/10.1186/s12974-019-1413-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374915PMC
February 2019
3 Reads

Expression, Regulation, and Function of the Calmodulin Accessory Protein PCP4/PEP-19 in Myometrium.

Reprod Sci 2019 Feb 11:1933719119828072. Epub 2019 Feb 11.

1 Department of Obstetrics and Gynecology, Division of Research, University of Kansas School of Medicine, Kansas City, KS, USA.

Objective:: Calmodulin (CaM) plays a key role in the orchestration of Ca signaling events, and its regulation is considered an important component of cellular homeostasis. The control of uterine smooth muscle function is largely dependent on the regulation of Ca and CaM signaling. The objective of this study was to investigate the expression, function, and regulation of CaM regulatory proteins in myometrium during pregnancy. Read More

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http://dx.doi.org/10.1177/1933719119828072DOI Listing
February 2019
10 Reads

Vaginal Ureaplasma parvum serovars and spontaneous preterm birth.

Am J Obstet Gynecol 2019 Feb 5. Epub 2019 Feb 5.

Division of Neonatology, Pediatric Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria.

Background: Ureaplasma species (spp) are the bacteria most often isolated from the amniotic cavity of women with preterm labor or preterm premature rupture of membranes; thus, the link between intrauterine Ureaplasma spp infection and adverse pregnancy outcome clearly is established. However, because vaginal Ureaplasma spp colonization is very common in pregnant women, the reason that these microorganisms cause ascending infections in some cases but remain asymptomatic in most pregnancies is not clear. Previous studies suggested an association between vaginal colonization with Ureaplasma parvum as opposed to U urealyticum and preterm delivery. Read More

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http://dx.doi.org/10.1016/j.ajog.2019.01.237DOI Listing
February 2019
3 Reads
4.704 Impact Factor

[Comparison of immunochromatographic (IC) and real-time polymerase chain reaction (Rt-PCR) tests for screening Neisseria gonorrhoeae, Chlamydia trachomatis, Ureaplasma spp. and Mycoplasma spp. in HIV-infected men].

Mikrobiyol Bul 2019 Jan;53(1):37-42

Hacettepe University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Ankara, Turkey.

Laboratory testing is critical for sexually transmitted infections (STIs) as most of the infected people usually have no symptoms. It is known that having HIV and STI coinfection increases the risk of HIV transmission. Sensitive tests are required for the infection control. Read More

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http://dx.doi.org/10.5578/mb.67694DOI Listing
January 2019
12 Reads

Oral and uro-vaginal intra-amniotic infection in women with preterm delivery: A case-control study.

J Investig Clin Dent 2019 Jan 20:e12396. Epub 2019 Jan 20.

Unit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, Colombia.

Aim: The aim of the present study was to establish the association between the presence of oral and uro-vaginal microorganisms in the placental membrane and preterm delivery (PTD), the premature rupture of membranes (PRM), and the clinical signs of intra-amniotic infection.

Methods: Eighty-four women with PTD and 127 women with delivery at term were assessed for the PRM, clinical signs of intra-amniotic infection, and the presence of periodontitis. Twenty-seven microorganisms were identified in the placental tissue using nested polymerase chain reaction (PCR). Read More

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http://dx.doi.org/10.1111/jicd.12396DOI Listing
January 2019
5 Reads

Turning the Tide against Antibiotic Resistance by Evaluating Novel, Halogenated Phenazine, Quinoline, and NH125 Compounds against Species Clinical Isolates and Type Strains.

Antimicrob Agents Chemother 2019 Mar 26;63(3). Epub 2019 Feb 26.

Department of Infectious Diseases and Immunology, College of Veterinary Medicine, University of Florida, Gainesville, Florida, USA

Escalating levels of antibiotic resistance in mycoplasmas, particularly macrolide resistance in and , have narrowed our antibiotic arsenal. Further, mycoplasmas lack a cell wall and do not synthesize folic acid, rendering common antibiotics, such as beta-lactams, vancomycin, sulfonamides, and trimethoprim, of no value. To address this shortage, we screened nitroxoline, triclosan, and a library of 20 novel, halogenated phenazine, quinoline, and NH125 analogues against species and clinical isolates from urine. Read More

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http://dx.doi.org/10.1128/AAC.02265-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395908PMC
March 2019
4 Reads

[Infection Status of Human Papilloma Virus,Ureaplasma Urealyticum, Chlamydia Trachomatis,and Neisseria Gonorrhoeae].

Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2018 Dec;40(6):817-821

Department of Clinical Laboratory,PUMC Hospital,CAMS and PUMC,Beijing 100730,China.

Objective To analyze the infection status of human papilloma virus (HPV),Ureaplasma urealyticum (UU),Chlamydia trachomatis (CT),and Neisseria gonorrhoeae (NG) in clinical patients.Methods The laboratory specimens including urine,urethral swabs,and cervical swabs from 870 patients from January 1st 2014 to December 31st 2017 were retrospectively analyzed. HPV-DNA was detected by multiplex fluorescent PCR,and the UU-RNA,CT-RNA,and NG-RNA were determined by isothermal nucleic acid amplification. Read More

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http://dx.doi.org/10.3881/j.issn.1000-503X.10636DOI Listing
December 2018
5 Reads

[Microbiological analysis of the maternal genital tract and umbilical cord blood and its association with neonatal damage].

Rev Argent Microbiol 2018 Dec 9. Epub 2018 Dec 9.

Laboratorio de Bacteriología Clínica, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba, CABA, Argentina. Electronic address:

The etiology leading to neonatal damage is multifactorial, being genital infections one of the causes. The objective of the study was to identify microorganisms of the maternal genital tract that are associated with neonatal damage, in order to prevent future perinatal complications. Seven hundred and eleven pregnant patients attended their prenatal control during the period January 2010-July 2013. Read More

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http://dx.doi.org/10.1016/j.ram.2017.09.005DOI Listing
December 2018
1 Read

Comparison of rRNA-based and DNA-based nucleic acid amplifications for detection of Chlamydia trachomatis, Neisseria gonorrhoeae, and Ureaplasma urealyticum in urogenital swabs.

BMC Infect Dis 2018 Dec 12;18(1):651. Epub 2018 Dec 12.

Department of Infection Control, Affiliated Hospital of Academy of Military Medical Sciences, Beijing, People's Republic of China.

Background: Nucleic acid amplification tests (NAAT) are well-accepted in diagnosis and surveillance of sexually infectious pathogens worldwide. However, performance differences between a RNA-based NAAT and DNA-based NAAT are rarely reported. This study compares the performances of the RNA-based SAT (simultaneous amplification and testing) assay and the DNA-based quantitative real-time polymerase chain reaction (qPCR) assay. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3580-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291997PMC
December 2018
12 Reads

Prevalence of Ureaplasma urealyticum, Chlamydia trachomatis, Neisseria gonorrhoeae and herpes simplex virus in Beijing, China.

Epidemiol Infect 2018 Dec 3:1-5. Epub 2018 Dec 3.

Department of Infection Control,Affiliated Hospital of Academy of Military Medical Sciences,Beijing,China.

The prevalence of sexually transmitted infection (STI) pathogens in Beijing, China, is rarely reported. In this study, 34 911 symptomatic outpatients with suspected genital infections who attended outpatient clinics in a tertiary care hospital were included to investigate the updated prevalence of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and herpes simplex virus (HSV) from 1 January 2013 to 31 December 2016 in Beijing, China. Results indicated that a decrease trend (UU, CT, NG and HSV) in male and an increase trend (UU, CT and NG) in female were observed during the period. Read More

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http://dx.doi.org/10.1017/S0950268818003163DOI Listing
December 2018
13 Reads

Adverse pregnancy and neonatal outcomes associated with a systematic review and meta-analysis protocol.

BMJ Open 2018 Nov 28;8(11):e024175. Epub 2018 Nov 28.

Public Health Interventions Research Group, Kirby Institute, University of New South Wales, Sydney, New South Wales, Australia.

Introduction: Several bacterial sexually transmitted and genital mycoplasma infections during pregnancy have been associated with poor pregnancy and perinatal outcomes. Comprehensive and systematic information about associations between sexually transmitted infections (STI) and genital infections in pregnancy and adverse perinatal outcomes is needed to improve understanding about the evidence for causal associations between these infections and adverse pregnancy and neonatal outcomes. Our primary objective is to systematically review the literature about associations between: (1) in pregnancy and preterm birth; (2) in pregnancy and preterm birth; (3) and/or in pregnancy and preterm birth. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278811PMC
November 2018
4 Reads

Ureaplasma urealyticum pyelonephritis presenting with progressive dysuria, renal failure, and neurologic symptoms in an immunocompromised patient.

Transpl Infect Dis 2019 Apr 10;21(2):e13032. Epub 2018 Dec 10.

Division of Pediatric Infectious Diseases, Department of Pediatrics, Washington University School of Medicine, Saint Louis, Missouri.

Ureaplasma urealyticum is a bacterial species correlated with urethritis in healthy individuals and invasive infections in immunocompromised patients. We describe a 20-year-old female with a history of remote heart transplant on everolimus, mycophenolate, and rituximab presenting with progressive urinary tract symptoms, renal failure, and neurologic symptoms. An extensive workup ultimately identified U urealyticum infection, and the patient successfully recovered after a course of azithromycin and doxycycline. Read More

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http://dx.doi.org/10.1111/tid.13032DOI Listing
April 2019
5 Reads

Culture- and PCR-based detection of BV associated microbiological profile of the removed IUDs and correlation with the time period of IUD in place and the presence of the symptoms of genital tract infection.

Ann Clin Microbiol Antimicrob 2018 Nov 22;17(1):40. Epub 2018 Nov 22.

Institute of Clinical Microbiology, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, Semmelweis St. 6, Szeged, 6725, Hungary.

Objectives: The long-term use of intrauterine devices (IUDs) may lead to biofilm formation on the surface. The aim of this study was to perform the culture- and PCR-based detection of bacteria/fungi from the biofilm of the removed IUDs with different time periods in place.

Methods: For a 2-year period, 100 IUD users were involved in the study. Read More

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http://dx.doi.org/10.1186/s12941-018-0293-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6249738PMC
November 2018
16 Reads

Evaluation of the Associations Between Cervical Microbiota and HPV Infection, Clearance, and Persistence in Cytologically Normal Women.

Cancer Prev Res (Phila) 2019 Jan 21;12(1):43-56. Epub 2018 Nov 21.

Department of Gynecological Oncology, Beijing Obstetrics and Gynecology Hospital of Capital Medical University, Beijing, China.

The aim of this study was to investigate the associations between cervical microbiota and different human papillomavirus (HPV) infection statuses in cytologically normal women. The cervical microbiota of HPV-positive or -negative women with a normal cytologic diagnosis was characterized and compared using 16S rDNA-based high-throughput sequencing, and the differences in cervical microbiota associated with new acquisition, persistence, and clearances of HPV genotypes were analyzed via one-year follow-up. The results showed that the cervical microbial richness of HPV-positive women was lower than for HPV-negative women, and the difference was more significant in the postmenopausal group relative to the premenopausal group. Read More

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http://dx.doi.org/10.1158/1940-6207.CAPR-18-0233DOI Listing
January 2019
17 Reads

Effect of antenatal azithromycin for Ureaplasma spp. on neonatal outcome at ≤30 weeks' gestational age.

Pediatr Int 2019 Jan;61(1):58-62

Department of Pediatrics, Hallym University Medical Center, Seoul, Korea.

Background: Ureaplasma spp. in the maternal genitourinary tract has come to attention as a cause of preterm labor, spontaneous abortion, chorioamnionitis and adverse outcomes. A few controversies, however, still remain, namely, whether it should be treated aggressively or not. Read More

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http://dx.doi.org/10.1111/ped.13738DOI Listing
January 2019
37 Reads

[Sexually transmitted infections and male fertility].

Hautarzt 2018 Dec;69(12):1006-1013

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Background: Sexually transmitted infections (STI) are common worldwide and can cause impairment of fertility. In women pelvic inflammatory disease with subsequent tubal sterility is well-documented but the influence of STI on male fertility is still controversely discussed OBJECTIVE: The effects of various bacterial and viral STI on male fertility are discussed.

Material And Methods: An evaluation of the international literature up to 30 April 2018 was carried out including studies on larger collectives from the Asiatic region. Read More

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http://link.springer.com/10.1007/s00105-018-4300-9
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http://dx.doi.org/10.1007/s00105-018-4300-9DOI Listing
December 2018
7 Reads

Initial microbial community of the neonatal stomach immediately after birth.

Gut Microbes 2018 Nov 7:1-9. Epub 2018 Nov 7.

c Department of Bioinformatics and Genomics , University of North Carolina at Charlotte , Charlotte , USA.

The purpose of this prospective cross-sectional cohort pilot study is to explore the initial microbial community of gastric aspirate fluid as collected immediately after birth and its relationships with mode of delivery and preterm birth. Twenty-nine gastric aspirate samples collected immediately after birth from infants born between 24-40 weeks gestation were analyzed for microbial composition. Total microbial content was low in many samples, with a substantial number sharing taxonomic composition with negative controls. Read More

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http://dx.doi.org/10.1080/19490976.2018.1520578DOI Listing
November 2018
9 Reads

Antibiotics for amniotic-fluid colonization by Ureaplasma and/or Mycoplasma spp. to prevent preterm birth: A randomized trial.

PLoS One 2018 7;13(11):e0206290. Epub 2018 Nov 7.

Inserm UMR 1153, Obstetrical, Perinatal and Pediatric Epidemiology Research Team (Epopé), Center for Epidemiology and Statistics Sorbonne Paris Cité, DHU Risks in pregnancy, Paris Descartes University, Paris, France.

Objective: To assess whether antibiotics used for treatment in asymptomatic second-trimester women positive for Mycoplasma or Ureaplasma spp. detected by amniotic-fluid PCR prevents preterm delivery.

Design: A randomized, double-blind, placebo-controlled trial. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0206290PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221323PMC
April 2019
21 Reads

Successful treatment of Ureaplasma-induced hyperammonemia syndrome post-lung transplant.

Transpl Infect Dis 2019 Feb 22;21(1):e13022. Epub 2018 Nov 22.

Division of Allergy, Pulmonary, and Critical Care, Department of Internal Medicine, University of Wisconsin Hospital and Clinics, University of Wisconsin School of Medicine-Madison School of Medicine and Public Health, Madison, Wisconsin.

Hyperammonemia, in the absence of significant liver dysfunction, is an uncommon but often fatal occurrence following orthotopic lung transplant. Prior reports have provided evidence to support Ureaplasma species as an etiology for this syndrome. This case report describes an individual post-lung transplant, treated emperically with doxycycline along with other measures to lower ammonia levels, at the time hyperammonemia with encephalopathy was recognized. Read More

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http://doi.wiley.com/10.1111/tid.13022
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http://dx.doi.org/10.1111/tid.13022DOI Listing
February 2019
20 Reads

Urogenital pathogens, associated with Trichomonas vaginalis, among pregnant women in Kilifi, Kenya: a nested case-control study.

BMC Infect Dis 2018 Nov 6;18(1):549. Epub 2018 Nov 6.

Laboratory Bacteriology Research, Faculty of Medicine and Health Sciences, Ghent University, De Pintelaan, 185, Ghent, Belgium.

Background: Screening of curable sexually transmitted infections is frequently oriented towards the diagnosis of chlamydia, gonorrhea, syphilis and trichomoniasis, whereas other pathogens, sometimes associated with similar urogenital syndromes, remain undiagnosed and/or untreated. Some of these pathogens are associated with adverse pregnancy outcomes.

Methods: In a nested case-control study, vaginal swabs from 79 pregnant women, i. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3455-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219184PMC
November 2018
29 Reads

Mycoplasma genitalium Infections in Women Attending a Sexually Transmitted Disease Clinic in New Orleans.

Clin Infect Dis 2018 Oct 23. Epub 2018 Oct 23.

Department of Medicine, Section of Infectious Diseases, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, USA.

Background: Several studies have reported statistically significant associations of Mycoplasma genitalium with cervicitis, urethritis, or vaginal discharge, although non-significant associations have also been reported. This study examined the associations of M. genitalium with selected sexually transmitted infections (STIs), demographic, behavioral, and clinical factors among women attending a sexually transmitted disease (STD) clinic in New Orleans. Read More

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http://dx.doi.org/10.1093/cid/ciy922DOI Listing
October 2018
5 Reads

Prevalence of Ureaplasma spp. and Mycoplasma hominis in healthy women and patients with flora alterations.

Diagn Microbiol Infect Dis 2019 Mar 4;93(3):227-231. Epub 2018 Oct 4.

Femicare Clinical Research for Women, 3300, Gasthuismolenstraat 31, Tienen, Belgium; Department of Obstetrics and Gynecology, Antwerp University, 2000, Prinsstraat 13, Antwerp, Belgium.

The objective was to estimate the prevalence of Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum in healthy women and patients with altered vaginal microflora. Vaginal samples from 2594 unselected female patients were divided into normal, bacterial vaginosis (BV), and aerobic vaginitis (AV) groups and tested for U. parvum, U. Read More

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http://dx.doi.org/10.1016/j.diagmicrobio.2018.10.001DOI Listing
March 2019
3 Reads

Association of cervical microbial community with persistence, clearance and negativity of Human Papillomavirus in Korean women: a longitudinal study.

Sci Rep 2018 Oct 19;8(1):15479. Epub 2018 Oct 19.

Division of Cancer Epidemiology and Management, Center for Uterine Cancer, National Cancer Center, Ilsandong-gu, Goyang, Republic of Korea.

The present study aimed to identify the cervical microbes that are associated with HPV negativity, HPV clearance and HPV persistence and to assess the microbes' longitudinal associations as related to HPV infection dynamics among Korean women. We enrolled 41 women with 107 samples, and classified them according to the HPV infection dynamics: HPV negativity (21 samples, 10 subjects), HPV clearance (42 samples, 15 subjects), and HPV persistence (44 samples, 16 subjects). Cervical swabs were collected at the baseline and six-month-interval follow-up visits. Read More

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http://dx.doi.org/10.1038/s41598-018-33750-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195586PMC
October 2018
17 Reads

Clinical Chorioamnionitis at Term: New Insights into the Etiology, Microbiology, and the Fetal, Maternal and Amniotic Cavity Inflammatory Responses.

Nogyogyaszati Szuleszeti Tovabbkepzo Szemle 2018 Jun;20(3):103-112

Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U. S. Department of Health and Human Services, Bethesda, Maryland, and Detroit, Michigan, USA.

Clinical chorioamnionitis is the most common infection related diagnosis made in labor and delivery units worldwide. It is traditionally believed to be due to microbial invasion of the amniotic cavity, which elicits a maternal inflammatory response characterized by maternal fever, uterine tenderness, maternal tachycardia and leukocytosis. The condition is often associated with fetal tachycardia and a foul smelling amniotic fluid. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177213PMC
June 2018
19 Reads

Human papilloma virus genotype distribution and risk factor analysis amongst reproductive-age women in urban Gambia.

J Med Microbiol 2018 Nov 9;67(11):1645-1654. Epub 2018 Oct 9.

2​School of Life Sciences, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK.

Purpose: Cervical cancer is the most frequently diagnosed female cancer in The Gambia, representing approximately 30 % of cases. In 2014, the quadrivalent human papilloma virus (HPV) vaccine was introduced, which offers protection against HPV genotypes 6, 11, 16 and 18. To evaluate the potential effectiveness of this vaccine, genotype distribution and risk factor analysis were assessed. Read More

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http://www.microbiologyresearch.org/content/journal/jmm/10.1
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http://dx.doi.org/10.1099/jmm.0.000848DOI Listing
November 2018
35 Reads
2.250 Impact Factor

Vaginal Ureaplasma species increase chorioamnionitis in very preterm infants with preterm premature rupture of the membranes at < 28 weeks of gestation.

Eur J Clin Microbiol Infect Dis 2018 Dec 22;37(12):2371-2380. Epub 2018 Sep 22.

Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke-shi, Tochigi, 329-0498, Japan.

Our aim was to investigate the association between vaginal Ureaplasma species (spp.) and the subsequent occurrence of chorioamnionitis (CAM), perinatal death, neonatal morbidity, and long-term neurodevelopmental impairments (NDIs) at 3 years of age. We analyzed 55 pregnant women with singleton pregnancy who had preterm premature rupture of the membranes (pPROM) at < 28 weeks of gestation, and delivered between 22 and 31 weeks at our tertiary hospital in 2007-2016. Read More

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http://dx.doi.org/10.1007/s10096-018-3385-5DOI Listing
December 2018
7 Reads

Sexually Transmitted Infections Detected by Multiplex Real Time PCR in Asymptomatic Women and Association with Cervical Intraepithelial Neoplasia.

Rev Bras Ginecol Obstet 2018 Sep 19;40(9):540-546. Epub 2018 Sep 19.

Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Objective:  To determine the frequency of sexually transmitted infections (STIs) in asymptomatic women and the association of STIs with cervical intraepithelial neoplasia (CIN).

Methods:  A cross-sectional study was performed, enrolling women examined in a general gynecology clinic and in a colposcopy referral center from October 2014 to October 2015. The colposcopy group consisted of 71 women, and the general gynecology group consisted of 55 women. Read More

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http://dx.doi.org/10.1055/s-0038-1669994DOI Listing
September 2018
9 Reads

[Zhibai Dihuang Decoction improves sperm mitochondrial permeability transition in rats with ureaplasma urealyticum infection].

Zhonghua Nan Ke Xue 2018 Jun;24(6):540-546

Hunan University of Chinese Medicine, Changsha, Hunan 410208, China.

Objective: To investigate the effects of Zhibai Dihuang Decoction (ZDD) on sperm mitochondrial permeability transition (MPT) in the rat model of ureaplasma urealyticum (UU) infection (UUI).

Methods: Ninety male SD rats were randomly divide into five groups: normal control, UUI model control, ZDD, doxycycline, and ZDD + doxycycline. The UUI model was established in the latter four groups of rats by UU injection into the bladder. Read More

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June 2018
9 Reads

[Bacterial culture of donor semen: Analysis of results].

Zhonghua Nan Ke Xue 2018 Jun;24(6):504-508

Zhejiang Research Institute for Family Planning Science and Technology, Hangzhou, Zhejiang 310012, China.

Objective: To investigate bacterial infection and the distribution of different bacterial species in the donor semen and the influence of different bacterial counts on semen quality.

Methods: Bacterial colonies in the semen samples from 1 126 donors were counted with the Synbiosis Protocol 3 Automatic Colony Counter and the bacterial species with a colony count ≥10⁴ cfu/ml identified with the VITEK2 Compact Automatic Biochemical Analyzer. The Makler Sperm Counting Board was used to examine the semen quality of the semen samples with a colony count = 0 cfu/ml (n = 22, group A), those with a colony count <10⁴ cfu/ml (n = 22, group B) and those with a colony count ≥10⁴ cfu/ml (n = 22, group C). Read More

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June 2018
30 Reads

[Association of Ureaplasma urealyticum with the types of antisperm antibody in infertile men].

Zhonghua Nan Ke Xue 2018 Feb;24(2):147-151

Center of Reproductive Medicine, Suzhou Hospital Affiliated to Nanjing Medical University, Suzhou, Jiangsu 215002, China.

Objective: To investigate the prevalence of Ureaplasma urealyticum (UU) infection in infertile men, its influence on routine semen parameters and the distribution of antisperm antibody (AsAb) and its types in infertile patients with UU infection.

Methods: We detected the positive rate of UU infection, semen parameters, and the distribution of AsAb and its types in 662 infertile men and 25 normal fertile male controls followed by comparison of the obtained data between the two groups of subjects.

Results: The positive rate of UU infection was significantly higher in the infertile men than in the normal controls (52. Read More

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February 2018
30 Reads

The Role of Polymorphonuclear Leukocyte Counts from Urethra, Cervix, and Vaginal Wet Mount in Diagnosis of Nongonococcal Lower Genital Tract Infection.

Infect Dis Obstet Gynecol 2018 26;2018:8236575. Epub 2018 Jul 26.

Oslo University Hospital, Department of Venereology, The Olafia Clinic, Norwegian National Advisory Unit on Sexually Transmitted Infections, Oslo, Norway.

Objective: The aim of this study was to evaluate whether the polymorphonuclear leukocyte (PMNL) inflammatory response in women with nongonococcal lower genital tract infection (LGTI) can be used to optimize criteria for syndromic treatment.

Methods: A cross-sectional study of 375 women attending the STI clinic in Oslo. Urethral, cervical, and vaginal specimens underwent microscopy for PMNLs. Read More

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http://dx.doi.org/10.1155/2018/8236575DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6083538PMC
January 2019
11 Reads

Sexually transmitted agents and their association with leucocytospermia in infertility clinic patients.

Andrologia 2018 Dec 20;50(10):e13127. Epub 2018 Aug 20.

Department of Medical Microbiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

In this study, the presence of Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma hominis, Mycoplasma genitalium, Ureaplasma urealyticum and Ureaplasma parvumDNA were investigated using real-time multiplex PCR detection kit in the urine samples of 50 patients who presented to the infertility polyclinic. Patients were classified into two groups in accordance with the WHO leucocytospermia criteria as over 1 × 10 /ml (n = 25) and below 1 × 10 /ml (controls; n = 25). In addition, the semen sample results of the patients were evaluated. Read More

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http://dx.doi.org/10.1111/and.13127DOI Listing
December 2018
26 Reads

Gut Microbiome in BALB/c and C57BL/6J Mice Undergoing Experimental Thyroid Autoimmunity Associate with Differences in Immunological Responses and Thyroid Function.

Horm Metab Res 2018 Dec 14;50(12):932-941. Epub 2018 Aug 14.

Faculty of Life Sciences & Medicine, King's College London, London, UK.

Experimental models of hyperthyroid Graves' disease (GD) and Graves' orbitopathy (GO) are efficiently developed by genetic immunisation by electroporation with human thyrotropin hormone receptor (hTSHR) A-subunit plasmid in female BALB/c (H-2d) mice. We investigated susceptibility in C57BL/6 J (H-2b) animals to allow studies on disease mechanisms in transgenic and immune response gene knock-out mice. Higher numbers of female C57BL/6 J were positive for pathogenic thyroid stimulating antibodies, but induced hyperthyroidism remained at a low frequency compared to BALB/c animals. Read More

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http://dx.doi.org/10.1055/a-0653-3766DOI Listing
December 2018
5 Reads

Activities of the Benzoquinolizine Fluoroquinolone Levonadifloxacin (WCK 771) and Other Antimicrobial Agents against Mycoplasmas and Ureaplasmas in Humans, Including Isolates with Defined Resistance Mechanisms.

Antimicrob Agents Chemother 2018 Nov 24;62(11). Epub 2018 Oct 24.

Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA

Levonadifloxacin (WCK 771) was evaluated against 68 type strains and clinical isolates of , , , and spp. in comparison with moxifloxacin, levofloxacin, tetracycline, and azithromycin or clindamycin. Levonadifloxacin MICs were ≤0. Read More

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http://aac.asm.org/lookup/doi/10.1128/AAC.01348-18
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http://dx.doi.org/10.1128/AAC.01348-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201079PMC
November 2018
5 Reads