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Georgian Med News 2021 Mar(312):114-118

1Asfendiyarov Kazakh National Medical University, Department of Obstetrics and Gynecology, Almaty, Kazakhstan.

The purpose of our study was to determine the prevalence of urogenital mixed infections and the sensitivity of mycoplasmas and ureaplasmas to antibiotics in reproductive aged women with pelvic inflammatory disease. 4720 samples of biomaterial were obtained by urethral and cervical canal scrapings in 2360 women of reproductive age with pelvic inflammatory disease (2 samples from each woman). In 2360 samples, Chlamydia trachomatis, Trichomonas vaginalis and Gardnerella vaginalis were determined by multiplex PCR. Read More

Clin Transplant 2021 May 4:e14334. Epub 2021 May 4.

College of Medicine, University of the Philippines Manila, Taft Ave, Manila, Philippines.

Background: Hyperammonemia syndrome (HS) is reported to occur in patients with Ureaplasma spp. infections. We performed a systematic review and meta-analysis of studies reporting HS in patients with Ureaplasma spp. Read More

Children (Basel) 2021 Apr 3;8(4). Epub 2021 Apr 3.

Division of Neonatology, Intensive Care and Neuropediatrics, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, 1090 Vienna, Austria.

Vaginal colonization with () spp. has been shown to be associated with adverse pregnancy outcome; however, data on neonatal outcome are scarce. The aim of the study was to investigate whether maternal vaginal colonization with spp. Read More

Adv Biomed Res 2020 23;9:78. Epub 2020 Dec 23.

Department of Human Anatomy, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India.

Background: Gestational diabetes mellitus (GDM) is one of the commonly occurring high-risk obstetric complications that accounts for 4%-9% of total pregnancies. The present study was an attempt to assess the effect of GDM on composition of the neonatal oral microbiota.

Materials And Methods: In this study, oral samples from 155 full-term vaginally delivered newborns were collected with sterile swabs. Read More

Asian Pac J Cancer Prev 2021 Apr 1;22(4):1239-1246. Epub 2021 Apr 1.

Department of Clinical Analysis and Biomedicine, Clinical Cytology Laboratory, State University of Maringá (UEM), Paraná, Brazil.

Objective: The present report investigated the rates of coinfections between high-rik human papillomavirus (hrHPV) and the most important human mycoplasmas including Mycoplasma hominis, M. genitalium, Ureaplasma urealyticum and U. parvum in cervical samples of asymptomatic brazilian population. Read More

Am J Reprod Immunol 2021 Apr 27:e13435. Epub 2021 Apr 27.

Department of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Institute, Ewha Womans University, Seoul, Korea.

Problem: Preterm birth (PTB) is a major cause of increased morbidity and mortality in newborns. The main cause of spontaneous PTB (sPTB) is the activation of an inflammatory response as a result of ascending genital tract infection. Despite various studies on the effects of the vaginal microbiome on PTB, a practical method for its clinical application has yet to be developed. Read More

J Appl Microbiol 2021 Apr 26. Epub 2021 Apr 26.

Microbiology and Infection Research Group, Department of Biomedical Science, Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.

Aims: To use a flow-based method to establish, quantify and visualize biofilms of Ureaplasma parvum.

Methods And Results: Absorbance readings of a U. parvum HPA5 culture were taken at 550 nm every 3 h for 30 h in order to establish a growth curve, with viability determined by the number of colour changing units (CCUs). Read More

Rev Esp Quimioter 2021 Apr 22. Epub 2021 Apr 22.

José Gutiérrez-Fernández. Laboratorio de Microbiología. Hospital Universitario Virgen de las Nieves. Avenida de las Fuerzas Armadas, 2. E-18012 Granada, Spain.

Objective: Infections by genitopathogens are a frequent reason for consultation in Primary Health Care and in the specialties of Infectious Diseases, Urology, Gynecology, and Dermatology. The most common causes are opportunistic microorganisms and responsible for sexually transmitted infections associated with unprotected sex. The objective is to determine the microorganisms that cause these infections in patients treated at the Hospital Universitario Virgen de las Nieves in Granada and Neisseria gonorrhoeae susceptibility to antibiotics. Read More

J Low Genit Tract Dis 2021 Apr 22. Epub 2021 Apr 22.

Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, Sweden Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

Objective: This study aimed to investigate the prevalence of sexually transmitted infections (STIs) and colonizing bacteria in relation to urogenital symptoms.

Materials And Methods: In this cross-sectional study, patients visiting the STI clinic at Umeå University Hospital were asked for symptoms and condom use. Samples from 759 patients (465 male and 294 female) were analyzed for 4 STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) and 3 colonizing bacteria (Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum). Read More

Womens Health (Lond) 2021 Jan-Dec;17:17455065211009181

School of Medicine, Texas Tech University Health Sciences Center (TTUHSC) at the Permian Basin, Odessa, TX, USA.

Background And Purpose: play a vital role in protecting the vagina against pathogens. Cytokines are vital components of defense against infections in women. The genital mycoplasmas, and , are associated with various infectious diseases in adults and infants. Read More

J Infect Chemother 2021 Apr 11. Epub 2021 Apr 11.

Department of Laboratory Medicine, The People's Hospital of Liaoning Province, Shenyang, China. Electronic address:

Objectives: The aim of this study was to estimate the prevalence and antimicrobial susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in a comprehensive teaching hospital Shenyang, China over the past 4 years.

Methods: A total of 1448 individuals with urogenital symptoms underwent mycoplasma testing between April 2016 and March 2020. Detection, identification and antimicrobial susceptibility testing were carried out using Mycoplasma ID/AST kits. Read More

Z Geburtshilfe Neonatol 2021 Apr 9. Epub 2021 Apr 9.

Universitätsfrauenklinik, Medizinische Fakultät der Universität Rostock, Rostock, Deutschland.

Introduction: In spite of insufficient evidence, we assume a high willingness to diagnose and treat vaginal infections in threatened preterm births in Germany.

Methods: Online survey on the management of infection in threatened preterm birth in all 212 German perinatal centers.

Results: The response rate was 31. Read More

J Urol 2021 Mar 29:101097JU0000000000001750. Epub 2021 Mar 29.

Division of Pelvic Medicine and Reconstructive Surgery, Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California.

Purpose: For patients with persistent irritative lower urinary tract symptoms, such as dysuria and urinary frequency, evaluation for the atypical organisms Ureaplasma and Mycoplasma has been a common part of care. However, these species are genitourinary colonizers and have not been established as causative pathogens in chronic lower urinary tract symptoms. We therefore sought to evaluate diagnostic testing patterns for Ureaplasma and Mycoplasma and characterize the associations of these bacteria with irritative lower urinary tract symptoms using molecular detection techniques. Read More

Rev Esp Quimioter 2021 Mar 18. Epub 2021 Mar 18.

Enrique García Sánchez, Departamento de Ciencias Biomédicas. Facultad de Medicina. Universidad de Salamanca. Spain.

Within Mycoplasma genus, M. pneumoniae, M. genitalium, M. Read More

BMC Infect Dis 2021 Mar 17;21(1):268. Epub 2021 Mar 17.

Departments of Neonatology, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

Background: Neonatal meningitis is a severe infectious disease of the central nervous system with high morbidity and mortality. Ureaplasma parvum is extremely rare in neonatal central nervous system infection.

Case Presentation: We herein report a case of U. Read More

PeerJ 2021 3;9:e10793. Epub 2021 Mar 3.

Department of Pathology, Faculty of health sciences, University of Cape Town, Cape Town, South Africa.

Background: South African women of reproductive age have a high burden of sexually transmitted infections (STIs), including human papillomavirus (HPV) infection. However, there is limited information on the prevalence of sexually transmitted pathogens in women from rural Eastern Cape Province, South Africa. The study aims at determining the prevalence of sexually transmitted pathogens and co-infection with high-risk (HR) HPV among women from rural Eastern Cape Province, South Africa. Read More

Front Med (Lausanne) 2021 22;8:614239. Epub 2021 Feb 22.

Department of Pediatrics, Maastricht University Medical Center, Maastricht, Netherlands.

Perinatal inflammatory stress is strongly associated with adverse pulmonary outcomes after preterm birth. Antenatal infections are an essential perinatal stress factor and contribute to preterm delivery, induction of lung inflammation and injury, pre-disposing preterm infants to bronchopulmonary dysplasia. Considering the polymicrobial nature of antenatal infection, which was reported to result in diverse effects and outcomes in preterm lungs, the aim was to examine the consequences of sequential inflammatory stimuli on endogenous epithelial stem/progenitor cells and vascular maturation, which are crucial drivers of lung development. Read More

Front Public Health 2021 22;9:615110. Epub 2021 Feb 22.

Institut de Recerca Biomédica de Lleida Fundació Dr. Pifarré (IRBLleida), Lleida, Spain.

(CT) infection has increased in recent years, reaching 127 million cases in 2016. Possible complications, especially among women, require intervention for early detection of the infection. The objective of our study was to determine the prevalence of CT infection in a young, sexually active, asymptomatic population. Read More

Front Vet Sci 2021 18;8:572171. Epub 2021 Feb 18.

Department of Biointeraction, Multidisciplinary Institute of Health, Universidade Federal da Bahia, Vitória da Conquista, Brazil.

The class encompasses wall-less microbes with a reduced genome. They may infect plants, insects, humans, and animals including those on farms and in livestock. is a mollicute associated with decreased reproduction mainly in the conception rate in cattle, as well as weight loss and decreased quality in milk production. Read More

BMJ Case Rep 2021 Mar 5;14(3). Epub 2021 Mar 5.

Infectious Diseases, Nottingham University Hospitals NHS Trust, Nottingham, UK.

Usual culture methods to identify pathogenic bacteria can be unsuccessful, particularly when working with fastidious organisms. We present a case of early periprosthetic knee joint infection with only identified using 16S ribosomal RNA PCR. This case represents the impact molecular methods of bacterial identification can have on clinical care allowing for more targeted antimicrobial therapy; something which is imperative in an era of increasing antimicrobial resistance. Read More

Front Pediatr 2021 16;9:632573. Epub 2021 Feb 16.

Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

There are mutual influences between intestine and lung, that propose a concept of the gut-lung axis, but the mechanism is still unclear. Microbial colonization in early life plays an important role in regulating intestinal and lung function. In order to explore the characteristics of early microbiota on the gut-lung axis, we studied the correlation between intestinal and pharyngeal microbiota on day 1 and day 28 after birth in premature neonates. Read More

PLoS One 2021 4;16(3):e0247618. Epub 2021 Mar 4.

Department of Neonatal Medicine, Kagoshima City Hospital, Kagoshima, Japan.

Introduction: A simple and rapid diagnosis of Ureaplasma spp. is required for the choice of the appropriate antibiotic. However, an ideal detection method has not been available. Read More

Pediatr Res 2021 Mar 3. Epub 2021 Mar 3.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: To assess the potential impact of azithromycin treatment in the first week following birth on 2-year outcomes in preterm infants with and without Ureaplasma respiratory colonization who participated in a double-blind, placebo-controlled randomized controlled trial.

Methods: Respiratory morbidity was assessed at NICU discharge and at 6, 12, and 22-26 months corrected age using pulmonary questionnaires. Comprehensive neurodevelopmental assessments were completed between 22 and 26 months corrected age. Read More

Medicina (Kaunas) 2021 Feb 26;57(3). Epub 2021 Feb 26.

Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", University Street, no 16, 700115 Iasi, Romania.

Ureaplasma urealyticum (UU) and Mycoplasma hominis (MH) are two commensal microorganisms that form the urogenital microbiota. Under a state of dysbiosis, both bacteria cause intrauterine infection. Therefore, the purpose of the present study was to analyze the prevalence of UU and MH among four hundred and eleven infertile women. Read More

Sex Med 2021 Apr 27;9(2):100314. Epub 2021 Feb 27.

Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Seoul Asan Medical Center, Seoul, Republic of Korea.

Introduction: Vulvodynia, vulvar pain syndrome, is defined as vulvar pain of at least a 3-month duration without a clear identifiable cause, which may have associated factor and the etiology and treatment of this challenging disease is still unclear. Dyspareunia is a relevant symptom of patients with vulvodynia. Vaginal microbiome has known an important role in local immune-inflammatory responses and it may be important pathogenic mechanism in vulvodynia. Read More

An Bras Dermatol 2021 Mar-Apr;96(2):176-183. Epub 2021 Jan 31.

Department of Sexually Transmitted Infections, Fundação Alfredo da Matta, Manaus, AM, Brazil; Department of Dermatology, Universidade do Estado do Amazonas, Manaus, AM, Brazil. Electronic address:

Background: Sexually transmitted infections (STI) are a global public health problem. Urethritis are among the most common STIs, and can cause several complications and facilitate the transmission of the HIV virus.

Objectives: To investigate the main etiologic agents of urethritis in 170 men treated at Fundação Alfredo da Matta. Read More

Transplantation 2021 Mar;105(3):e35-e36

Division of Thoracic Surgery, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL.

Med Microbiol Immunol 2021 Feb 17;210(1):73-80. Epub 2021 Feb 17.

Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.

The focus on urogenital mycoplasmas as the possible etiologic agents of urogenital infections and syndromes, has increased in the last decade. Of these, Mycoplasma genitalium is proven to be pathogenic and sexually transmitted. We compared five commercially available assays for the detection of these organisms in urogenital mycoplasma culture specimen remnants. Read More

Antimicrob Agents Chemother 2021 Feb 16. Epub 2021 Feb 16.

TU Dresden, Institute of Medical Microbiology and Hygiene, Dresden, Germany.

and are mollicutes species that colonize the urogenital tract of many asymptomatic persons but are also thought to be associated with symptomatic infections. Using 170 strains isolated between 2016 and 2019 in a German university hospital, resistance was tested by a combination of commercial tests, molecular methods and determination of minimal inhibitory concentrations. Rates of resistance to macrolides, tetracyclines and fluoroquinolones were 0%, 4. Read More

Front Pediatr 2020 22;8:593802. Epub 2021 Jan 22.

Department of Pediatrics, Universiti Kebangsaan Malaysia Medical Center, Kuala Lumpur, Malaysia.

(GV) is most frequently associated with bacterial vaginosis and is the second most common etiology causing intrauterine infection after . Intrauterine GV infection adversely affects pregnancy outcomes, resulting in preterm birth, fetal growth restriction, and neonatal pneumonia. The knowledge of how GV exerts its effects is limited. Read More