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Sci Rep 2022 Jun 16;12(1):10148. Epub 2022 Jun 16.

Department of Obstetrics and Gynecology, College of Medicine, Ewha Medical Research Institute, Ewha Womans University, 1071, Anyangcheon-ro, Yangcheon-gu, Seoul, 07985, Korea.

Ureaplasma and Prevotella infections are well-known bacteria associated with preterm birth. However, with the development of metagenome sequencing techniques, it has been found that not all Ureaplasma and Prevotella colonizations cause preterm birth. The purpose of this study was to determine the association between Ureaplasma and Prevotella colonization with the induction of preterm birth even in the presence of Lactobacillus. Read More

Clin Lab 2022 Jun;68(6)

Background: The aim of this study was to investigate the infection and antimicrobial resistance of Ureaplasma urealyticum (U. urealyticum) and Mycoplasma hominis (M. hominis) in patients with genital tract diseases in Jiangsu, China. Read More

J Int Med Res 2022 Jun;50(6):3000605221106410

The First School of Clinical Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu Province, China.

Objective: To elucidate the mechanism underlying how (UU) affects sperm quality and identify a therapeutic target.

Methods: In this prospective observational study, the differences in and relationships among semen volume, pH, viscosity, liquefaction time, sperm concentration, sperm motility [progressive motility (PR)], and seminal polymorphonuclear (PMN) elastase were analyzed in 198 normal semen samples (control group) and 198 UU-infected semen samples (observation group). The UU-infected samples were treated and the above parameters were compared between the two groups. Read More

J Clin Microbiol 2022 Jun 13:e0052622. Epub 2022 Jun 13.

Department of Pathology, grid.471401.7grid.21107.35Johns Hopkins University School of Medicinegrid.471401.7, Baltimore, Maryland, USA.

Next-generation sequencing (NGS) workflows applied to bronchoalveolar lavage (BAL) fluid specimens could enhance the detection of respiratory pathogens, although optimal approaches are not defined. This study evaluated the performance of the Respiratory Pathogen ID/AMR (RPIP) kit (Illumina, Inc.) with automated Explify bioinformatic analysis (IDbyDNA, Inc. Read More

Infez Med 2022 1;30(2):247-253. Epub 2022 Jun 1.

Department of Microbiology, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

Bacterial vaginosis is a condition caused by changes in the vaginal microbial ecosystem and increases the risk of preterm delivery, premature rupture of membranes, endometritis, and weight loss of the baby. This study aimed to evaluate the frequency of gonococcal and non-gonococcal genital infections in women referred to clinics in Ilam, Iran. Two swab samples were taken from each patient using a sterile swab, one swab was placed in a THB medium for the culture of and the other in PBS buffer for PCR. Read More

Placenta 2022 Jun 5;126:12-16. Epub 2022 Jun 5.

Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, 16066, USA. Electronic address:

Introduction: Necrotizing funisitis is a distinct lesion of the umbilical cord associated with chorioamnionitis and bloodborne fetal infection. The lesion may be a response to microorganisms in Wharton's jelly. A common microorganism detected in chorioamnionitis is Ureaplasma urealyticum (U. Read More

Curr Opin Infect Dis 2022 06;35(3):262-268

Divisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Purpose Of Review: Hyperammonemia syndrome is an increasingly recognized and often fatal condition that occurs in immunosuppressed individuals, most commonly lung transplant recipients. Growing evidence suggests hyperammonemia syndrome is associated with systemic infections caused by urease-producing organisms, namely Ureaplasma spp., an organism unable to grow with routine culturing techniques. Read More

Comput Math Methods Med 2022 25;2022:2498306. Epub 2022 May 25.

Department of Andrology, NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province, Guangzhou 510060, China.

Objective: To explore the risk of Ureaplasma urealyticum () affecting sperm quality.

Methods: Prospective cross-sectional study was conducted. In total, 340 semen samples were collected. Read More

Microbiol Spectr 2022 Jun 1:e0222921. Epub 2022 Jun 1.

Division of Medical Virology, Department of Pathology, Faculty of Health Sciences, University of Cape Towngrid.7836.a, Cape Town, South Africa.

Bacterial vaginosis (BV) is a common polymicrobial vaginal disorder that is associated with sexually transmitted infections (STIs), including HIV. Several studies have utilized broad-range 16S rRNA gene PCR assays with sequence analysis to characterize cervicovaginal bacterial communities of women with healthy and diseased conditions. With the high burden of BV and STIs among African women, there is a need for targeted PCR assays that can rapidly determine the true epidemiological profile of key cervical microbes, including BV-associated bacteria, and a need to explore the utility of such assays for microbiological diagnosis of BV. Read More

Stomatologiia (Mosk) 2022 ;101(3):18-21

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.

The Aim Of The Study: The study by the method of tissue polymerase chain reaction of the species composition of the microbiota of lesions of the oral mucosa in patients with bullous lesions.

Material And Methods: Biopsy specimens of the oral mucosa of 51 patients were studied by the polymerase chain reaction method, of which 14 patients with pemphigus vulgaris, 17 patients with pemphigoid bullosa, and 20 patients with the bullous form of ruber lichen planus. 4 types of microorganisms have been identified - Fusobacterium, Streptococcus pneumoniae, Candida albicans, Ureaplasma spp. Read More

Pol J Microbiol 2022 Feb 27;71(1):19-26. Epub 2022 Feb 27.

Jagiellonian University Medical College, Faculty of Medicine, Chair of Epidemiology and Preventive Medicine, Department of Epidemiology, Cracow, Poland.

Genital tract ureaplasma infections are associated with numerous complications, ranging from inflammation, through infertility, to problematic pregnancy. In the course of ureaplasma infection, the risk of human papillomavirus infection increases. Diagnostic tests for urea-plasma infections are not always carried out, especially in women with the normal Nugent test results. Read More

Int J Mol Sci 2022 May 17;23(10). Epub 2022 May 17.

Department of Dermatology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, 40138 Bologna, Italy.

Background: (CT) is the agent of the most common bacterial sexually transmitted infection worldwide. Until now, little information is available about the microbial composition of urine samples during CT urethritis. Therefore, in this study, we characterized the microbiome and metabolome profiles of first-void urines in a cohort of women with CT urethral infection attending an STI clinic. Read More

Diagnostics (Basel) 2022 May 4;12(5). Epub 2022 May 4.

Institute of Microbiology, Lausanne University Hospital and University of Lausanne, CH-1011 Lausanne, Switzerland.

is an important cause of sexually transmitted infections (STI) in Western countries. It is often asymptomatic, and thus, left untreated, and can have severe negative consequences, such as tubal infertility or adverse pregnancy outcomes. Other sexually transmitted microorganisms, such as and , as well as normal residents of the vaginal flora, such as genital mycoplasmas, also negatively impact human sexual and reproductive health. Read More

Wellcome Open Res 2022 11;7. Epub 2022 May 11.

Clinical research, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.

Early onset neonatal sepsis (EONS) typically begins prior to, during or soon after birth and may be rapidly fatal. There is paucity of data on the aetiology of EONS in sub-Saharan Africa due to limited diagnostic capacity in this region, despite the associated significant mortality and long-term neurological impairment. We compared pathogens detected in cord blood samples between neonates admitted to hospital with possible serious bacterial infection (pSBI) in the first 48 hours of life (cases) and neonates remaining well (controls). Read More

J Obstet Gynaecol 2022 May 17:1-5. Epub 2022 May 17.

School of Medicine, Islamic Azad University, Tonekabon Branch, Tonekabon, Iran.

Infertility is one of the major health problems of patients suffering from bacterial infections. Given the high percentage of infertility, the aim of this study was to investigate the prevalence of , and in fertile and infertile women. In the prospective study, 65 infertile patients and 54 pregnant women referred to Mahdieh Hospital in Tehran were included. Read More

Lancet Microbe 2022 Apr 9;3(4):e284-e293. Epub 2022 Mar 9.

Department of Biostatistics and Informatics, University of Colorado, Colorado School of Public Health, Aurora, CO, USA.

Background: Lower respiratory tract infections (LRTI) are a leading cause of critical illness and mortality in mechanically ventilated children; however, the pathogenic microbes frequently remain unknown. We combined traditional diagnostics with metagenomic next generation sequencing (mNGS) to evaluate the cause of LRTI in critically ill children.

Methods: We conducted a prospective, multicentre cohort study of critically ill children aged 31 days to 17 years with respiratory failure requiring mechanical ventilation (>72 h) in the USA. Read More

Microbiol Spectr 2022 May 9:e0009922. Epub 2022 May 9.

Department of Clinical Laboratory, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China.

The activity of two new fluoroquinolones, delafloxacin and finafloxacin, were evaluated against and spp. The MICs of delafloxacin, finafloxacin, and two classical fluoroquinolones (moxifloxacin and levofloxacin) were tested against 29 and 67 spp. isolates using the broth microdilution method. Read More

Rev Esp Quimioter 2022 06 29;35(3):301-303. Epub 2022 Apr 29.

Miguel Fernández-Huerta, Servicio de Microbiología, Hospital Universitario de Navarra, Spain.

Infect Dis Now 2022 Jun 26;52(4):227-229. Epub 2022 Apr 26.

Laboratory of Microbiology, Virgen de las Nieves University Hospital-IBS Instituto de Investigación Biosanitaria de Granada, Granada, Spain; Department of Microbiology, School of Medicine and PhD Program in Clinical Medicine and Public Health, University of Granada-IBS, Granada, PC, 18010, Spain.

Background: We report for the first time the association of Haemophilus pittmaniae and Haemophilus sputorum with urethritis in men who have sex with men and who engage in unprotected intercourse.

Patients And Methods: A search for genital pathogens was conducted using urethral exudate cultures and PCR tests for Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Mycoplasma spp., and Ureaplasma spp. Read More

J Crit Care 2022 08 18;70:154042. Epub 2022 Apr 18.

Department of Anesthesiology, University of Minnesota Medical School, Departments of Anesthesiology & Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI, United States of America.

Hyperammonemia occurs frequently in the critically ill but is largely confined to patients with hepatic dysfunction or failure. Non-hepatic hyperammonemia (NHHA) is far less common but can be a harbinger of life-threatening diagnoses that warrant timely identification and, sometimes, empiric therapy to prevent seizures, status epilepticus, cerebral edema, coma and death; in children, permanent cognitive impairment can result. Subsets of patients are at particular risk for developing NHHA, including the organ transplant recipient. Read More

Front Pharmacol 2022 31;13:860498. Epub 2022 Mar 31.

Department of Obstetrics and Gynecology, University Hospital Hradec Kralove, Faculty of Medicine in Hradec Kralove, Charles University, Hradec Kralove, Czech Republic.

To determine the prevalence and load of spp. DNA in the cervical fluid of women with singleton pregnancies complicated by preterm prelabor rupture of membranes (PPROM) with respect to intra-amniotic infection, sterile intra-amniotic inflammation, and colonization of the amniotic fluid. A total of 217 women with PPROM between gestational ages 24 + 0 and 33 + 6 weeks were included in this study. Read More

Microb Pathog 2022 May 14;166:105528. Epub 2022 Apr 14.

University of Science and Technology of Masuku (USTM), Faculty of Sciences, Department of Biology, B.P: 943, Franceville, Gabon.

Background: Genital mycoplasma are only considered pathogenic at a certain level and are often associated with other pathological situations such as bacterial vaginosis (BV). They may lead to infertility as well as other gynaeco-obstetrical and neonatal problems. Despite numerous reported resistances, macrolides are required to treat pregnant women while non-pregnant women are managed with tetracyclines and fluoroquinolones. Read More

Georgian Med News 2022 Mar(324):32-37

Azerbaijan Medical University, Department of Obstetrics and Gynecology; Scientific Research Institute of Obstetrics and Gynecology, Baku, Azerbaijan.

The aim of this study was to optimize the diagnosis of postpartum inflammatory complications. 150 puerperas who gave written informed consent to participate in clinical and laboratory studies were divided into two groups: the main group included puerperas with developed postpartum complications (n = 100), the comparison group included puerperas with a physiological course of the postpartum period (n = 50). The data of biochemical blood tests and bacteriological analysis of aspirated vaginal contents under aseptic conditions after childbirth were used as material. Read More

Aging Male 2022 Dec;25(1):125-133

Department of Microbiology and Parasitology, Hanoi Medical University's Hospital, Hanoi, Vietnam.

Objective: To explore the microbial etiology of urethritis in Vietnamese men and the association with patients' characteristics, especially their sexual behaviors.

Methods: This study was conducted on 349 men who presented with symptomatic urethritis and evidence of STIs (determined by multiplex PCR tests) at the Department of Andrology and Sexual Medicine-Hanoi Medical University Hospital. All information regarding medical history, sexual activities, and symptoms of urethritis was documented. Read More

Vet Clin Pathol 2022 Apr 5. Epub 2022 Apr 5.

Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.

Can J Infect Dis Med Microbiol 2022 22;2022:2812788. Epub 2022 Mar 22.

Al-Shunar Infertility Center, Nablus, West Bank, State of Palestine.

Introduction: urogenital tract infections are considered a possible cause of infertility worldwide. Genital infections are difficult and impractical to diagnose by culturing or serology. included in this study were , , and . Read More

Arch Ital Urol Androl 2022 Mar 29;94(1):62-64. Epub 2022 Mar 29.

Specialist Urology and Andrology Clinic, Salerno.

Objective: Propionibacterium acnes has been implicated in the pathogenesis of prostate disease as acute and chronic prostatic inflammation, benign prostatic hyperplasia and prostate cancer although it should still be clarified if Propionibacterium acnes (P. acnes) is a commensal or accidental prostate pathogen. Aiming to evaluate the pathogenic potential for genitourinary tract of Propionibacterium acnes, we investigated the frequency of P. Read More

J Matern Fetal Neonatal Med 2022 Mar 27:1-10. Epub 2022 Mar 27.

Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA.

Objective: To describe the characteristics of amniotic fluid sludge obtained from patients in term and preterm gestations.

Methods: This cross-sectional study included patients with dense aggregates of particulate matter detected in amniotic fluid, observed with transvaginal sonography. All patients were in labor and had an impending delivery, either preterm or at term. Read More

BMC Infect Dis 2022 Mar 25;22(1):283. Epub 2022 Mar 25.

Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, No. 20, Section 3, Renmin South Road, Chengdu, Sichuan, 610041, People's Republic of China.

Background: The aim of this study was to analyze the present situation of Ureaplasma urealyticum (UU), Chlamydia trachomatis (CT), Mycoplasma genitalium (MG) and Neisseria gonorrhoeae (NG) infections among obstetrics and gynecological outpatients in southwest China.

Methods: A total of 3225 urogenital swabs were included in this study. All swabs were tested by RNA-based simultaneous amplification and testing (SAT) methods. Read More

Cell Mol Neurobiol 2022 Mar 25. Epub 2022 Mar 25.

Division of Neonatology, Department of Women's and Children's Health, Center for Pediatric Research Leipzig, University of Leipzig Medical Center, Liebigstraße 20a, 04103, Leipzig, Germany.

Ureaplasma species (spp.) are considered commensals of the adult genitourinary tract, but have been associated with chorioamnionitis, preterm birth, and invasive infections in neonates, including meningitis. Data on mechanisms involved in Ureaplasma-driven neuroinflammation are scarce. Read More