359,668 results match your criteria Upper Respiratory Tract Infection


Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA

Respiratory tract infections due to community-acquired respiratory viruses including respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus are detected in up to 40% of allogeneic hematopoietic stem cell transplant recipients in whom they cause severe symptoms including pneumonia and bronchiolitis and can be fatal. Given the lack of effective antivirals and the data from our group demonstrating that adoptively transferred ex vivo-expanded virus-specific T cells can be clinically beneficial for the treatment of both latent (Epstein-Barr virus, cytomegalovirus, BK virus, human herpesvirus 6) and lytic (adenovirus) viruses, we investigated the potential for extending this immunotherapeutic approach to respiratory viruses. We now describe a system that rapidly generates a single preparation of polyclonal (CD4+ and CD8+) virus-specific T cells reactive against 12 antigens derived from 4 viruses (respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus) that commonly cause post-transplant morbidity and mortality. Read More

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http://dx.doi.org/10.3324/haematol.2018.206896DOI Listing

Unequal Rates of Serious Perioperative Respiratory Adverse Events Between Black and White Children.

J Natl Med Assoc 2019 Apr 16. Epub 2019 Apr 16.

Department of Anesthesiology, Section of Pediatric Anesthesiology, University of Michigan, Ann Arbor, MI, USA.

Background: Recent data among pediatric otolaryngology patients showed unexplained higher rates of serious perioperative respiratory adverse events (PRAE) in black children compared to their white peers. We evaluated whether preoperative respiratory comorbidity (PRC) burden contributes to racial disparity in serious PRAE in children undergoing non-otolaryngologic procedures.

Methods: Rates of serious PRAE (laryngospasm and/or bronchospasm) were compared across racial groups in a retrospective cohort of black and white children (N = 18538; black 10%) who underwent various elective, non-otolaryngologic procedures between 2007 and 2014 at a US tertiary Children's hospital. Read More

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http://dx.doi.org/10.1016/j.jnma.2019.03.006DOI Listing

Gemifloxacin-Induced Allergic Myocardial Infarction: A Case Report.

J Emerg Med 2019 Apr 16. Epub 2019 Apr 16.

Department of Cardiology, Faculty of Medicine, Muğla University, Muğla, Turkey.

Background: Gemifloxacin given once daily for 5-7 days has been shown to be non-inferior to, or in some instances superior to, comparator agents for the treatment of common lower respiratory tract infections. Gemifloxacin is generally well tolerated and is as safe as many frequently empirically prescribed antimicrobials.

Case Report: We report a case of a 46-year-old woman given gemifloxacin for an upper respiratory tract infection who developed allergic myocardial infarction 15 min after taking an oral dose of 320 mg gemifloxacin. Read More

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http://dx.doi.org/10.1016/j.jemermed.2019.03.001DOI Listing

A possible link between recurrent upper respiratory tract infections and lower cytokine production in patients with Q fever fatigue syndrome.

Eur J Immunol 2019 Apr 18. Epub 2019 Apr 18.

Radboud Expertise Center for Q fever, Department of Internal Medicine, Division of Infectious Diseases, Radboud university medical center, P.O. Box 9101, 6500, HB, Nijmegen, the Netherlands.

Besides fatigue, many Q fever fatigue syndrome (QFS) patients also complain of frequently recurring upper respiratory tract infections with severe symptoms. We investigated whether immunologic dysregulation contributes to these complaints. Cytokine and chemokine production was measured after stimulating monocytes of QFS patients and sex-matched healthy controls with LPS and several viral ligands. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.20184801
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http://dx.doi.org/10.1002/eji.201848012DOI Listing
April 2019
1 Read

Prevalence of health care-associated infections and antimicrobial resistance of the responsible pathogens in Ukraine: Results of a multicenter study (2014-2016).

Am J Infect Control 2019 Apr 15. Epub 2019 Apr 15.

Department of Anatomy, Topographical Anatomy, and Operative Surgery, Private Higher Educational Establishment "Kyiv Medical University," Kyiv, Ukraine.

Background: The aim of this study was to obtain the first national estimates of the current prevalence and incidence and death of health care-associated infections (HAIs) of all types in acute care hospitals in Ukraine.

Methods: Prospective surveillance was conducted from January 2014 to December 2016 in 17 hospitals. Surveillance case definitions were derived from the Centers for Disease Control and Prevention's National Healthcare Safety Network HAI case definitions. Read More

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http://dx.doi.org/10.1016/j.ajic.2019.03.007DOI Listing

More targeted use of oseltamivir and in-hospital isolation facilities after implementation of a multifaceted strategy including a rapid molecular diagnostic panel for respiratory viruses in immunocompromised adult patients.

J Clin Virol 2019 Apr 7;116:11-17. Epub 2019 Apr 7.

Department of Infectious Diseases, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.

Background: Immunocompromised adults are more vulnerable to a complicated course of viral respiratory tract infections (RTI).

Objectives: Provide evidence on the effect of implementation of rapid molecular diagnostics for viruses on use of in-hospital isolation facilities, oseltamivir and antibiotic usage, and other clinical outcomes in immunocompromised patients.

Study Design: A before-after study during two consecutive respiratory viral seasons, including immunocompromised adult patients presenting at a tertiary care emergency department with clinical suspicion of RTI. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13866532193007
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http://dx.doi.org/10.1016/j.jcv.2019.04.003DOI Listing
April 2019
1 Read

Reducing inappropriate outpatient antibiotic prescribing: normative comparison using unblinded provider reports.

BMJ Open Qual 2019 13;8(1):e000351. Epub 2019 Feb 13.

Center for Healthcare Innovation, Ochsner Health System, New Orleans, Louisiana, USA.

Importance: Antibiotic resistance is a global health issue. Up to 50% of antibiotics are inappropriately prescribed, the majority of which are for acute respiratory tract infections (ARTI).

Objective: To evaluate the impact of unblinded normative comparison on rates of inappropriate antibiotic prescribing for ARTI. Read More

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http://dx.doi.org/10.1136/bmjoq-2018-000351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440589PMC
February 2019

Respiratory syncytial virus, human metapneumovirus, and influenza virus infection in Bangkok, 2016-2017.

PeerJ 2019 11;7:e6748. Epub 2019 Apr 11.

Center of Excellence in Clinical Virology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Children and adults residing in densely populated urban centers around the world are at risk of seasonal influenza-like illness caused by respiratory viruses such as influenza virus, human metapneumovirus (hMPV), and respiratory syncytial virus (RSV). In a large metropolitan of Thailand's capital city Bangkok, most respiratory infections are rarely confirmed by molecular diagnostics. We therefore examined the frequency of RSV, hMPV, and influenza virus in 8,842 patients who presented influenza-like illness and sought medical care at a large hospital in Bangkok between 2016 and 2017. Read More

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http://dx.doi.org/10.7717/peerj.6748DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462397PMC
April 2019
1 Read

Trend of antibiotic susceptibility of isolated from respiratory tract infections in tertiary care hospital in south Karnataka.

Iran J Microbiol 2019 Feb;11(1):13-18

Department of Microbiology, Deendayalupadhyay Hospital, New Delhi, India.

Background And Objectives: is recognized as an important pathogen of respiratory tract infections. The rapidly, emerging problem of antibiotic resistant is a major issue nowadays. The present study aimed to evaluate the antibiotic susceptibility of isolated from upper respiratory tract infections in tertiary care hospital of south Karnataka. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462275PMC
February 2019

The p.P479L variant in CPT1A is associated with infectious disease in a BC First Nation.

Paediatr Child Health 2019 May 6;24(2):e111-e115. Epub 2018 Aug 6.

Department of Pathology and Laboratory Medicine, BC Children's Hospital, University of British Columbia, Vancouver, British Columbia.

Background: The hepatic carnitine palmitoyltransferase I () p.P479L variant is common in Aboriginal populations across coastal British Columbia, Alaska, the Canadian North, and Greenland. While the high frequency of this variant suggests positive selection, other studies have shown an association with sudden unexpected death in infancy and infection. Read More

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https://academic.oup.com/pch/article/24/2/e111/5067175
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http://dx.doi.org/10.1093/pch/pxy106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462176PMC
May 2019
1 Read

Nasal CPAP on paediatric air transport in the Canadian Arctic: A case series.

Paediatr Child Health 2019 May 13;24(2):e94-e97. Epub 2018 Jun 13.

Department of Anaesthesia, Qikiqtani General Hospital, Iqaluit, Nunavut.

Aims: Paediatric transport in remote regions of Canada represents a huge challenge given the acuity of the patients, immense distances, weather and lack of road infrastructure. Transport of patients in the Baffin region of Nunavut is completed entirely by air transport. Two very common paediatric transports are in regards to lower respiratory tract infections and premature deliveries in small rural communities north of Iqaluit. Read More

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http://dx.doi.org/10.1093/pch/pxy088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6462123PMC

Recurrent Cough and Expectoration for 10 Years: A Case Report.

Glob Pediatr Health 2019 4;6:2333794X19833725. Epub 2019 Apr 4.

The Third Affiliated Hospital of Zunyi Medical College, Zunyi, China.

. Most cases of cystic fibrosis occur in Europe, with only a few occurring in Asia. Pulmonary cystic fibrosis is not a rare disease, but in children it is a potentially life-threatening condition. Read More

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http://journals.sagepub.com/doi/10.1177/2333794X19833725
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http://dx.doi.org/10.1177/2333794X19833725DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449808PMC
April 2019
3 Reads

Respiratory tract virus infections in the elderly with pneumonia.

BMC Geriatr 2019 Apr 16;19(1):111. Epub 2019 Apr 16.

Department of Pediatrics and Adolescent Medicine, University of Turku and Turku University Hospital, PO Box 52, 20520, Turku, Finland.

Background: In children suffering from severe lower airway illnesses, respiratory virus detection has given good prognostic information, but such reports in the elderly are scarce. Therefore, our aim was to study whether the detection of nasopharyngeal viral pathogens and conventional inflammatory markers in the frail elderly correlate to the presence, signs and symptoms or prognosis of radiographically-verified pneumonia.

Methods: Consecutive episodes of hospital care of patients 65 years and older with respiratory symptoms (N = 382) were prospectively studied as a cohort. Read More

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https://bmcgeriatr.biomedcentral.com/articles/10.1186/s12877
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http://dx.doi.org/10.1186/s12877-019-1125-zDOI Listing
April 2019
6 Reads

Off-Label High-Dose Secukinumab for the Treatment of Moderate-to-Severe Psoriasis.

J Cutan Med Surg 2019 Apr 16:1203475419843118. Epub 2019 Apr 16.

7 Division of Dermatology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: Secukinumab is an anti-IL-17A monoclonal antibody approved for the treatment of moderate-to-severe psoriasis in adult patients. Despite its favourable safety and efficacy profile in clinical trials, some patients in clinical practice fail to respond adequately to the approved maintenance regimen of 300 mg subcutaneous monthly. Some clinicians manage these patients by using off-label high-dose secukinumab regimens, which include shortening the dosing interval to 300 mg every 2 or 3 weeks instead of monthly, or increasing the monthly dose to 450 mg. Read More

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http://dx.doi.org/10.1177/1203475419843118DOI Listing
April 2019
7 Reads

Human rhinovirus spatial-temporal epidemiology in rural coastal Kenya, 2015-2016, observed through outpatient surveillance.

Wellcome Open Res 2018 27;3:128. Epub 2019 Mar 27.

Epidemiology and Demography Department, KEMRI-Wellcome Trust Research Programme, Kilifi, +254, Kenya.

Human rhinovirus (HRV) is the predominant cause of upper respiratory tract infections, resulting in a significant public health burden. The virus circulates as many different types (168), each generating strong homologous, but weak heterotypic, immunity. The influence of these features on transmission patterns of HRV in the community is understudied. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.14836.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234744.2PMC
March 2019
4 Reads

Azithromycin reduces airway inflammation induced by human rhinovirus in lung allograft recipients.

Respirology 2019 Apr 15. Epub 2019 Apr 15.

Telethon Kids Institute, Centre for Health Research, The University of Western Australia, Perth, WA, Australia.

Background And Objective: Human rhinovirus (RV) is a common upper and lower respiratory pathogen in lung allograft recipients causing respiratory tract exacerbation and contributing towards allograft dysfunction and long-term lung decline. In this study, we tested the hypothesis that RV could infect both the small and large airways, resulting in significant inflammation.

Methods: Matched large and small airway epithelial cells (AEC) were obtained from five lung allograft recipients. Read More

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http://dx.doi.org/10.1111/resp.13550DOI Listing
April 2019
1 Read

Effects of Tokishakuyakusan on regeneration of murine olfactory neurons in vivo and in vitro.

Chem Senses 2019 Apr 16. Epub 2019 Apr 16.

Department of Otorhinolaryngology, Kanazawa Medical University, Ishikawa, Japan.

Post-upper respiratory tract infection related olfactory dysfunction typically occurs due to neural damage after an upper respiratory tract infection associated with a common cold or influenza. Recently, Tokishakuyakusan, a Japanese traditional Kampo medicine, has been found to be effective for post-viral olfactory dysfunction. However, the pharmacodynamics of Tokishakuyakusan in the treatment of post-viral olfactory dysfunction remain unresolved. Read More

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https://academic.oup.com/chemse/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/chemse/bjz023DOI Listing
April 2019
2 Reads

Oral manifestations of granulomatosis with polyangiitis - Clinical and radiological assessment.

J Dent Sci 2019 Mar 27;14(1):54-60. Epub 2018 Nov 27.

2nd Department of Medicine, Jagiellonian University Medical College, Krakow, Poland.

Background/purpose: Granulomatosis with polyangiitis (GPA) is a type of primary systemic vasculitis associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCA). GPA mainly affects medium and small vessels and may manifest in different organs, most commonly upper respiratory tract. Oral lesions occur in 6-13% of GPA patients and might be the first symptom observed by the patient. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S19917902183054
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http://dx.doi.org/10.1016/j.jds.2018.10.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445982PMC
March 2019
2 Reads

Fosfomycin: the characteristics, activity, and use in critical care.

Ther Clin Risk Manag 2019 27;15:525-530. Epub 2019 Mar 27.

Chronic Respiratory Diseases Research Center (CRDRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran,

Fosfomycin (CHOP) is a phosphonic acid derivative representing an epoxide class of antibiotics. The drug is a re-emerging bactericidal antibiotic with a wide range of actions against several Gram-positive and Gram-negative bacteria. Among the existing antibacterial agents, fosfomycin has the lowest molecular weight (138 Da), which is not structurally associated with other classes of antibiotics. Read More

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http://dx.doi.org/10.2147/TCRM.S199119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441553PMC
March 2019
3 Reads

Upsurge of Enterovirus D68 and Circulation of the New Subclade D3 and Subclade B3 in Beijing, China, 2016.

Sci Rep 2019 Apr 15;9(1):6073. Epub 2019 Apr 15.

School of Public Health, Capital Medical University, Beijing, 100069, P.R. China.

We conducted a surveillance among acute respiratory tract infection (ARTI) cases to define the epidemiology, clinical characteristics and genetic variations of enterovirus D68 (EV-D68) in Beijing, China from 2015 to 2017. Nasopharyngeal swabs and sputum were collected from 30 sentinel hospitals in Beijing and subjected to EV and EV-D68 detection by real-time PCR. The VP1 gene region and complete genome sequences of EV-D68 positive cases were analyzed. Read More

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http://dx.doi.org/10.1038/s41598-019-42651-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6465342PMC
April 2019
2 Reads

Safety and immunogenicity of a respiratory syncytial virus fusion glycoprotein F subunit vaccine in healthy adults: Results of a phase 1, randomized, observer-blind, controlled, dosage-escalation study.

Vaccine 2019 Apr 12. Epub 2019 Apr 12.

GSK, 14200 Shady Grove Rd, Rockville, MD 20850, USA. Electronic address:

Introduction: Respiratory syncytial virus (RSV) is a leading cause of acute lower respiratory tract infections in infants. An investigational vaccine using an engineered recombinant RSV fusion glycoprotein in its post-fusion conformation (RSV F subunit vaccine) has been developed to protect young infants via maternal immunization. This first-in-human, phase I, observer-blind study (NCT02298179) evaluated the safety and immunogenicity of different dosages and formulations of RSV F subunit vaccine in healthy non-pregnant women and men aged 18-45 years. Read More

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http://dx.doi.org/10.1016/j.vaccine.2019.04.011DOI Listing
April 2019
1 Read

Effect of Water Precautions on Otorrhea Incidence after Pediatric Tympanostomy Tube: Randomized Controlled Trial Evidence.

Otolaryngol Head Neck Surg 2019 Apr 16:194599819844487. Epub 2019 Apr 16.

8 Department of Otolaryngology, SUNY Downstate Medical Center, Brooklyn, New York, USA.

Objectives: Tympanostomy with ventilation tube insertion is the most common otologic surgery. Many surgeons recommend water precautions, although its utility is questioned. We aimed to investigate if water precautions reduce the rate of otorrhea after transtympanic tube insertion. Read More

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http://dx.doi.org/10.1177/0194599819844487DOI Listing
April 2019
1 Read

Progressive Immunodeficiency with Gradual Depletion of B and CD4⁺ T Cells in Immunodeficiency, Centromeric Instability and Facial Anomalies Syndrome 2 (ICF2).

Diseases 2019 Apr 4;7(2). Epub 2019 Apr 4.

Department of Clinical Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.

Immunodeficiency, centromeric instability and facial anomalies syndrome 2 (ICF2) is a rare autosomal recessive primary immunodeficiency disorder. So far, 27 patients have been reported. Here, we present three siblings with ICF2 due to a homozygous ZBTB24 gene mutation (c. Read More

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http://dx.doi.org/10.3390/diseases7020034DOI Listing
April 2019
1 Read

The Basics and the Advancements in Diagnosis of Bacterial Lower Respiratory Tract Infections.

Diagnostics (Basel) 2019 Apr 3;9(2). Epub 2019 Apr 3.

Motif BioSciences, Princeton, NJ 08540, USA.

Lower respiratory tract infections (LRTIs) are the leading infectious cause of death and the sixth-leading cause of death overall worldwide. , with more than 90 serotypes, remains the most common identified cause of community-acquired acute bacterial pneumonia. Antibiotics treat LRTIs with a bacterial etiology. Read More

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https://www.mdpi.com/2075-4418/9/2/37
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http://dx.doi.org/10.3390/diagnostics9020037DOI Listing
April 2019
2 Reads

Cystathionine γ-lyase deficiency enhances airway reactivity and viral-induced disease in mice exposed to side-stream tobacco smoke.

Pediatr Res 2019 Apr 15. Epub 2019 Apr 15.

Department of Pediatrics, Division of Clinical and Experimental Immunology and Infectious Diseases (CEIID), University of Texas Medical Branch, Galveston, TX, USA.

Background: Environmental tobacco smoke (ETS) is a known risk factor for severe respiratory syncytial virus (RSV) infections, yet the mechanisms of ETS/RSV comorbidity are largely unknown. Cystathionine γ-lyase regulates important physiological functions of the respiratory tract.

Methods: We used mice genetically deficient in the cystathionine γ-lyase enzyme (CSE), the major HS-generating enzyme in the lung to determine the contribution of HS to airway disease in response to side-stream tobacco smoke (TS), and to TS/RSV co-exposure. Read More

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http://dx.doi.org/10.1038/s41390-019-0396-6DOI Listing
April 2019
1 Read

The Polish Prevalence of Infection in Intensive Care (PPIC): A one-day point prevalence multicenter study.

Adv Clin Exp Med 2019 Apr 13. Epub 2019 Apr 13.

Department of Anesthesiology and Intensive Care, Wrocław University Hospital, Poland.

Background: Infections in critically ill patients are the main reasons for a lack of therapeutic success and increased mortality in intensive care units (ICUs). There have been many analyses of the incidence of infections in ICUs; however, no large studies of this kind have been conducted either in Poland or in Eastern and Central Europe.

Objectives: The aim of the research was to undertake a one-day study of the prevalence of infections in ICUs in Warsaw and the Mazovian region of Poland. Read More

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http://dx.doi.org/10.17219/acem/94147DOI Listing
April 2019
1 Read

Development of a Clinical Prediction Model for Central Line-Associated Bloodstream Infection in Children Presenting to the Emergency Department.

Pediatr Emerg Care 2019 Apr 11. Epub 2019 Apr 11.

†University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

Objective: The majority of the children with a central line who present to the emergency department with fever or other signs of bacteremia do not have a central line-associated bloodstream infection (CLABSI). Our objective was to develop a clinical prediction model for CLABSI among this group of children in order to ultimately limit unnecessary hospital admissions and antibiotic use.

Methods: We performed a nested case-control study of children with a central line who presented to the emergency department of an urban, tertiary care children's hospital between January 2010 and March 2015 and were evaluated for CLABSI with a blood culture. Read More

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http://dx.doi.org/10.1097/PEC.0000000000001835DOI Listing
April 2019
2 Reads

Live Usability Testing of Two Complex Clinical Decision Support Tools: Observational Study.

JMIR Hum Factors 2019 Apr 15;6(2):e12471. Epub 2019 Apr 15.

New York University School of Medicine, New York, NY, United States.

Background: Potential of the electronic health records (EHR) and clinical decision support (CDS) systems to improve the practice of medicine has been tempered by poor design and the resulting burden they place on providers. CDS is rarely tested in the real clinical environment. As a result, many tools are hard to use, placing strain on providers and resulting in low adoption rates. Read More

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http://humanfactors.jmir.org/2019/2/e12471/
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http://dx.doi.org/10.2196/12471DOI Listing
April 2019
3 Reads

Use of bioengineered human commensal gut bacteria-derived microvesicles for mucosal plague vaccine delivery and immunization.

Clin Exp Immunol 2019 Apr 15. Epub 2019 Apr 15.

Gut Microbes and Health Research Programme, Quadram Institute Bioscience, Norwich, UK.

Plague caused by the Gram-negative bacterium, Yersinia pestis, is still endemic in parts of the world today. Protection against pneumonic plague is essential to prevent the development and spread of epidemics. Despite this, there are currently no licensed plague vaccines in the western world. Read More

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http://dx.doi.org/10.1111/cei.13301DOI Listing
April 2019
1 Read

Parents awareness toward antibiotics use in upper respiratory tract infection in children in Al-Qassim region, Saudi Arabia.

J Family Med Prim Care 2019 Feb;8(2):583-589

Qassim College of Medicine, Qassim University, Qassim, Saudi Arabia.

Objectives: This study aimed to evaluate parents' awareness toward antibiotics use in upper respiratory tract infection in children.

Methods: This cross-sectional study conducted in Al-Qassim using validated and translated questionnaire whish was distributed using what's app. over a period of 3 months, extended from May 2018 to July 2018. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_368_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436261PMC
February 2019
1 Read

Knowledge and practices of primary health care physicians regarding updated guidelines of MERS-CoV infection in Abha city.

J Family Med Prim Care 2019 Feb;8(2):455-461

Department of Family Medicine, Ministry of Health, Abha, KSA.

Background: Human coronaviruses (hCoV) usually cause mild to moderate upper respiratory tract illnesses. The novel coronavirus (nCoV), or Middle East respiratory syndrome coronavirus (MERS-CoV), is a particular strain different from any other known hCoV with the possibility of human and also zoonotic transmissions. The aim of the study to assess primary health care (PHC) physicians' knowledge and adherence regarding Saudi Ministry of Health guidelines regarding MERS-CoV. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_336_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436268PMC
February 2019
1 Read

Contribution of Fcγ Receptor-Mediated Immunity to the Pathogenesis Caused by the Human Respiratory Syncytial Virus.

Front Cell Infect Microbiol 2019 29;9:75. Epub 2019 Mar 29.

Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.

The human Respiratory Syncytial Virus (hRSV) is the leading cause of severe acute lower respiratory tract infections (ALRTIs) in humans at all ages and is the main cause of hospitalization due to pneumonia, asthma, and bronchiolitis in infants. hRSV symptoms mainly develop due to an excessive host immune and inflammatory response in the respiratory tissue. hRSV infection during life is frequent and likely because of non-optimal immunological memory is developed against this virus. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450440PMC
March 2019
1 Read

Antigenic Site-Specific Competitive Antibody Responses to the Fusion Protein of Respiratory Syncytial Virus Were Associated With Viral Clearance in Hematopoietic Cell Transplantation Adults.

Front Immunol 2019 29;10:706. Epub 2019 Mar 29.

Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.

Recent studies of human sera showed that the majority of the respiratory syncytial virus (RSV) neutralizing antibodies are directed against pre-fusion conformation of the fusion (F) protein of RSV and revealed the importance of pre-fusion antigenic site Ø specific antibodies. However, detailed analysis of multiple antigenic site-specific competitive antibody responses to RSV F protein and their contribution to virus clearance in humans are lacking. We prospectively enrolled a cohort of RSV infected hematopoietic cell transplantation (HCT) adults ( = 40). Read More

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http://dx.doi.org/10.3389/fimmu.2019.00706DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449644PMC
March 2019
1 Read

Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice.

Front Immunol 2019 29;10:611. Epub 2019 Mar 29.

Department of Microbiology and Immunology, University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

Seasonally recurrent influenza virus infections are a significant cause of global morbidity and mortality. In murine models, primary influenza infection in the respiratory tract elicits potent humoral responses concentrated in the draining mediastinal lymph node and the spleen. In addition to immunity within secondary lymphoid organs (SLO), pulmonary infection is also associated with formation of ectopic inducible bronchus-associated tissues (iBALT) in the lung. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6450362PMC
March 2019
2 Reads

[Rhinosinusitis in children].

Rev Prat 2019 Mar;69(3):281-284

Service ORL, hôpital Robert-Debré, Paris, France.

Rhinosinusitis in children. Rhinosinusitis is an inflammatory disease of the nasal and sinusal mucosa. The diagnosis of an acute rhinosinusitis in a child is based on the persistence of the symptoms of a febrile upper respiratory tract infection for more than 7 to 10 days. Read More

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March 2019
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Respiratory viruses in adults hospitalised with Community-Acquired Pneumonia during the non-winter months in Melbourne: Routine diagnostic practice may miss large numbers of influenza and respiratory syncytial virus infections.

Commun Dis Intell (2018) 2019 04 15;43. Epub 2019 Apr 15.

Department of Medicine, Melbourne Medical School – Western Health, University of Melbourne General Internal medicine Unit, Western Health, St Albans, Vic

Background: Community-Acquired Pneumonia (CAP) is one of the highest health burden conditions in Australia. Disease notifications and other data from routine diagnosis suffers from selection bias that may misrepresent the true contribution of various aetiological agents. However existing Australian prospective studies of CAP aetiology have either under-represented elderly patients, not utilised Polymerase Chain Reaction (PCR) diagnostics or been limited to winter months. Read More

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April 2019
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Use of point-of-care tests and antibiotic prescribing in sore throat and lower respiratory infections by general practitioners.

Enferm Infecc Microbiol Clin 2019 Apr 10. Epub 2019 Apr 10.

Section of General Practice and Research Unit for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Introduction: This study was aimed at assessing general practitioners' (GP) reliance on patient history, examination findings and the influence of the utilisation of point-of-care tests (POCT) in antibiotic prescribing for sore throat and lower respiratory tract infections (LRTI).

Methods: Audit-based study carried out in 2015. A group of GPs received an intervention six years earlier with provision of POCTs and another group of GPs acted as controls. Read More

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http://dx.doi.org/10.1016/j.eimc.2019.02.005DOI Listing
April 2019
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Evaluating addition of self-collected throat swabs to nasal swabs for respiratory virus detection.

J Clin Virol 2019 Apr 4;115:43-46. Epub 2019 Apr 4.

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA, United States; Department of Laboratory Medicine, University of Washington, United States.

Background: Early and accurate detection of respiratory viruses (RV) is important for patient management. We have previously shown that self-collected nasal swabs (NS) are feasible and as sensitive as clinician-collected nasal washes for detection of RV, but the additive benefit of self-collected throat swabs is unknown.

Objectives: To evaluate the added yield of self-collected nasal to throat swabs for detection of RV by PCR in patients with upper respiratory tract infection (URTI) symptoms. Read More

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http://dx.doi.org/10.1016/j.jcv.2019.04.001DOI Listing
April 2019
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Haemophilus parasuis infection in 3D4/21 cells induces autophagy through the AMPK pathway.

Cell Microbiol 2019 Apr 11:e13031. Epub 2019 Apr 11.

Key Laboratory of Bacteriology, Ministry of Agriculture, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.

Haemophilus parasuis (H. parasuis) is a common commensal in the upper respiratory tract of pigs, but causes Glässer's disease in stress conditions. To date, many studies focused on the immune evasion and virulence of H. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cmi.13031
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http://dx.doi.org/10.1111/cmi.13031DOI Listing
April 2019
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Precision health: treating the individual patient with chronic obstructive pulmonary disease.

Med J Aust 2019 Apr 11. Epub 2019 Apr 11.

University of British Columbia, Vancouver, Canada.

Chronic obstructive pulmonary disease (COPD) is defined based on a reduced ratio of forced expiratory volume in one second (FEV ) to forced vital capacity (FVC) on spirometry. However, within this definition, there is significant heterogeneity of pathophysiological processes that lead to airflow obstruction and variation in phenotypic manifestations across patients. Current pharmacological treatments are based on large randomised clinical trials that apply to an "average" patient. Read More

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http://dx.doi.org/10.5694/mja2.50138DOI Listing
April 2019
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Chronic meningitis in a lung transplant recipient.

Med Mycol Case Rep 2019 Jun 25;24:41-43. Epub 2019 Mar 25.

Immunocompromised Host Infectious Diseases Service, Division of Infectious Diseases, Department of Medicine, and the Multi-Organ Transplant Program, University Health Network, University of Toronto, Toronto, Ontario, Canada.

spp. are common colonizers of the oral mucosa and respiratory tract in lung transplant recipients. Although thought to be non-pathogenic in most cases, donor derived infections related to Candida spp. Read More

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http://dx.doi.org/10.1016/j.mmcr.2019.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439223PMC
June 2019
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Cross-sectional study of the use of antimicrobials following common infections by rural residents in Anhui, China.

BMJ Open 2019 Apr 11;9(4):e024856. Epub 2019 Apr 11.

School of Health Services Management, Anhui Medical University, Hefei, China.

Objective: To describe help seeking behaviour from a medical doctor and antimicrobial use for common infections among rural residents of Anhui province, China.

Design: A cross-sectional retrospective household survey.

Setting: 12 administrative villages from rural Anhui, China. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02485
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http://dx.doi.org/10.1136/bmjopen-2018-024856DOI Listing
April 2019
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Visibility and transmission: complexities around promoting hand hygiene in young children - a qualitative study.

BMC Public Health 2019 Apr 11;19(1):398. Epub 2019 Apr 11.

National Ageing Research Institute LTD, 34-54 Poplar Road, Parkville, VIC, 3052, Australia.

Background: Effective hand hygiene practice can reduce transmission of diseases such as respiratory tract infections (RTIs) and gastrointestinal infections, especially in young children. While hand hygiene has been widely promoted within Australia, primary care providers' (PCPs) and parents' understanding of hand hygiene importance, and their views on hand hygiene in reducing transmission of diseases in the community are unclear. Therefore, the aim of this study was to explore the views of PCPs and parents of young children on their knowledge and practice of hand hygiene in disease transmission. Read More

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http://dx.doi.org/10.1186/s12889-019-6729-xDOI Listing
April 2019
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Airway Malformations and Bronchiectasis: A Pediatric Study.

Authors:
Amrita Dosanjh

Ear Nose Throat J 2019 Apr 11:145561319839606. Epub 2019 Apr 11.

1 Pediatric Respiratory, San Diego, CA, USA.

Congenital airway malformations are most often identified in early childhood. The development of bronchiectasis in association with malformations of the lower airway has been described, particularly among adult patients. The coexistence in a pediatric population of these conditions is not well described. Read More

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http://dx.doi.org/10.1177/0145561319839606DOI Listing

No Association between Vitamin D and Acute Respiratory Tract Infections Amongst Elite New Zealand Rugby Players and Rowers.

Int J Vitam Nutr Res 2019 Apr 11:1-8. Epub 2019 Apr 11.

1 Department of Human Nutrition, University of Otago, Dunedin, New Zealand.

Upper respiratory tract infections are the most common infections reported by elite athletes. Low vitamin D status has been associated with an increased risk of upper respiratory tract infections. The aim of this study was to investigate associations between serum 25-hydroxyvitamin D (25(OH)D), salivary immunoglobulin A (S-IgA) concentrations, and acute respiratory tract infections (colds/flu) (ARI) in elite rowers and rugby players. Read More

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http://dx.doi.org/10.1024/0300-9831/a000285DOI Listing
April 2019
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Evaluation of uncomplicated acute respiratory tract infection management in veterans: A national utilization review.

Infect Control Hosp Epidemiol 2019 Apr;40(4):438-446

Center for Medication Safety (VAMedSAFE),Hines Veterans Affairs Medical Center,Chicago, Illinois.

Background: Antibiotics are overprescribed for acute respiratory tract infections (ARIs). Guidelines provide criteria to determine which patients should receive antibiotics. We assessed congruence between documentation of ARI diagnostic and treatment practices with guideline recommendations, treatment appropriateness, and outcomes. Read More

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http://dx.doi.org/10.1017/ice.2019.16DOI Listing
April 2019
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Misdiagnosis of scrub typhus complicated by hemophagocytic syndrome.

BMC Pediatr 2019 Apr 10;19(1):102. Epub 2019 Apr 10.

Second Affiliated Hospital of Wenzhou Medical University, Wen Zhou, China.

Background: This study sought to analyze the cases of clinical misdiagnosis of scrub typhus complicated by hemophagocytic syndrome.

Methods: We retrospectively reviewed the medical records for diagnoses, clinical course, chest X-ray findings, laboratory data, and antibiotic therapy.

Results: All nine patients were misdiagnosed at the outpatient department between 07/2009 and 07/2017. Read More

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http://dx.doi.org/10.1186/s12887-019-1475-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458710PMC
April 2019
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Characteristics of cases of tuberculosis coinfected with HIV in Minas Gerais State in 2016.

Rev Inst Med Trop Sao Paulo 2019 8;61:e21. Epub 2019 Apr 8.

Universidade de São Paulo, Faculdade de Medicina de Ribeirão Preto, Programa de Pós-Graduação Strictu Sensu em Saúde na Comunidade, Ribeirão Preto, São Paulo, Brazil.

This study aimed to characterize the cases of tuberculosis (TB) co-infected with the human immunodeficiency virus (HIV) in Minas Gerais State, Brazil, after the notification sheet modification, and to verify the association between the new variables and the treatment outcome. It is an analytical cross-sectional study with TB/HIV cases notified in the year 2016 to the Brazilian Information System for Notifiable Diseases (Sistema de Informação de Agravos de Notificação). Descriptive statistics, chi-square test, and multiple correspondence analysis were performed to verify the association between the outcome, ageand associated diseases. Read More

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http://dx.doi.org/10.1590/S1678-9946201961021DOI Listing
April 2019
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Brincidofovir as a Salvage Therapy in Controlling Adenoviremia in Pediatric Recipients of Hematopoietic Stem Cell Transplant.

J Pediatr Hematol Oncol 2019 Apr 8. Epub 2019 Apr 8.

Faculty of Medicine and Health, University of Leeds, Leeds, UK.

Adenovirus infection is a well-known complication in patients receiving hematopoietic stem cell transplantation (HSCT). Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir, which has activity against adenoviruses. We present a review of adenovirus infections treated with BCV which were unresponsive to cidofovir initially in 4 patients and it was used upfront in one patient. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001480DOI Listing
April 2019
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Fc-Mediated Antibody Effector Functions During Respiratory Syncytial Virus Infection and Disease.

Front Immunol 2019 22;10:548. Epub 2019 Mar 22.

Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands.

Respiratory syncytial virus (RSV) is a major cause of severe lower respiratory tract infections and hospitalization in infants under 1 year of age and there is currently no market-approved vaccine available. For protection against infection, young children mainly depend on their innate immune system and maternal antibodies. Traditionally, antibody-mediated protection against viral infections is thought to be mediated by direct binding of antibodies to viral particles, resulting in virus neutralization. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438959PMC
March 2019
1 Read