373,536 results match your criteria Upper Respiratory Tract Infection

The protective effect of tight-fitting powered air-purifying respirators during chest compressions.

Am J Emerg Med 2021 Jun 7;49:172-177. Epub 2021 Jun 7.

Department of Emergency and Critical Care, Nagoya University Hospital, 65 Tsurumai, Showa, Nagoya, Aichi 466-8560, Japan. Electronic address:

Background: Airborne personal protective equipment is required for healthcare workers when performing aerosol-generating procedures on patients with infectious diseases. Chest compressions, one of the main components of cardiopulmonary resuscitation, require intense and dynamic movements of the upper body. We aimed to investigate the protective effect of tight-fitting powered air-purifying respirators (PAPRs) during chest compressions. Read More

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Evaluating the added value of multi-input atmospheric transport ensemble modeling for applications of the Comprehensive Nuclear Test-Ban Treaty organization (CTBTO).

J Environ Radioact 2021 Jun 9;237:106649. Epub 2021 Jun 9.

Comprehensive Nuclear Test-Ban Treaty Organization, Wagramerstrasse 5, 1400, Vienna, Austria.

The Comprehensive Nuclear Test-Ban Treaty Organization (CTBTO) runs to date operationally an atmospheric transport modeling chain in backward mode based on operational deterministic European Centre for Medium-Range Weather Forecasts-Integrated Forecasting System (ECMWF-IFS) and on National Centers for Environmental Prediction-Global Forecast System (NCEP-GFS) input data. Meanwhile, ensemble dispersion modeling is becoming more and more widespread due to the ever increasing computational power and storage capacities. The potential benefit of this approach for current and possible future CTBTO applications was investigated using data from the ECMWF-Ensemble Prediction System (EPS). Read More

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Anticoagulant-induced hemorrhagic cholecystitis with hemobilia after deceased donor kidney transplant and literature review.

Int J Surg Case Rep 2021 May 26;84:106027. Epub 2021 May 26.

Augusta University, Department of Surgery, United States of America. Electronic address:

Introduction And Importance: Hemobilia and hemorrhagic cholecystitis are uncommon causes of right upper quadrant abdominal pain. The development of intra-gallbladder and biliary bleeding has been primarily associated with abdominal trauma, malignancy, liver transplant, and iatrogenic injury to the biliary tree and vasculature. Spontaneous anticoagulant induced hemorrhagic cholecystitis and hemobilia are incredibly rare events and have only been documented by a handful of case reports. Read More

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The management of paediatric rhinosinusitis.

Int J Pediatr Otorhinolaryngol 2021 Jun 4;147:110786. Epub 2021 Jun 4.

Lewisham and Greenwich NHS Trust, United Kingdom. Electronic address:

Paediatric rhinosinusitis (PDRS) is commonly used as a synonym for rhinitis within healthcare. Although they may share common symptoms, the pathophysiology does differ; PDRS is the inflammation of the nasal mucosa in addition to the sinuses whereas rhinitis is the inflammation of just nasal mucosa. This review provides a comprehensive overview of the epidemiology, pathophysiology, symptoms, diagnosis and management of PDRS. Read More

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Analysis of prolactin and sexual side effects in patients with schizophrenia who switched from paliperidone palmitate to aripiprazole lauroxil.

Psychiatry Res 2021 May 27;302:114030. Epub 2021 May 27.

Alkermes, Inc., Waltham, MA, USA.

One strategy to address hyperprolactinemia and associated sexual side effects in patients receiving antipsychotics is switching to an antipsychotic not associated with prolactin elevation (eg, aripiprazole). This post hoc analysis assessed prolactin concentrations and sexual side effects in an open-label prospective study of switching long-acting injectable antipsychotics from paliperidone palmitate (PP) to aripiprazole lauroxil (AL). Serum prolactin was measured throughout the study. Read More

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J Stomatol Oral Maxillofac Surg 2021 Jun 9. Epub 2021 Jun 9.

Professor, Chief of the Service de Stomatologie et de Chirurgie Maxillo-faciale de la Pitié Salpétrière (France).

Objective: This pilot randomized crossover study evaluated the outcomes of two custom-made mandibular retention devices (MRDs), a computer-aided design (CAD)/computer-aided manufacturing (CAM) device (Narval CC™) and a non-CAD/CAM device (Narval™), on oropharyngeal airway volume in patients with obstructive sleep apnoea (OSA).

Methods: 12 OSA patients were recruited from an University Hospital for MRD therapy with either CAD/CAM or non-CAD/CAM first. A cone-beam computed tomography evaluation (CBCT) and polysomnography assessment was performed during baseline assessment and at the end of each study period. Read More

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Exploring the alternative: fish, flies and worms as preclinical models for ALS.

Neurosci Lett 2021 Jun 9:136041. Epub 2021 Jun 9.

KU Leuven - University of Leuven, Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute (LBI), Leuven, Belgium; VIB, Center for Brain & Disease Research, Laboratory of Neurobiology, Leuven, Belgium. Electronic address:

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder characterized by the loss of upper and lower motor neurons. In general, patients succumb to respiratory insufficiency due to respiratory muscle weakness. Despite many promising therapeutic strategies primarily identified in rodent models, patient trials remain rather unsuccessful. Read More

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Anesthesia or analgesia? New block for shoulder surgery: pericapsular nerve group block.

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

Kocaeli Derince Training and Research Hospital, Anesthesiology Department, Kocaeli, Turkey. Electronic address:

Interscalene brachial plexus (ISB) block is considered the analgesic technique of choice for shoulder surgery. However, the hemidiaphragmatic paresis that may occur after the block has led to the search for an alternative to the ISB block. In this case report, the pericapsular nerve group (PENG) block was performed for both surgical anesthesia and postoperative analgesia in two patients who underwent shoulder surgery. Read More

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Risk for hepatic and extra-hepatic outcomes in nonalcoholic fatty liver disease from the symposium: Non-Alcoholic fatty liver disease (NAFLD).

J Intern Med 2021 Jun 12. Epub 2021 Jun 12.

Division of Diagnostics and Specialist Medicine, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Non-alcoholic fatty liver disease (NAFLD) is defined by presence of steatosis in more than 5% of liver cells. The gold standard for diagnosis is liver biopsy, but this is seldom achieved due to costs and risk for side-effects, why the diagnosis is mostly made based on a combination of radiology and exclusion of other liver diseases. Disease severity staging can be non-invasively achieved with radiological exams such as elastography, or blood-based markers, that usually have lower sensitivity and specificity. Read More

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Inflammatory disease of the costotransverse joints: US evaluation in 15 symptomatic patients.

J Ultrasound 2021 Jun 12. Epub 2021 Jun 12.

Advanced Musculoskeletal Ultrasound, SIUMB School of Pisa, Pisa, Italy.

The costotransverse joints (CTJs) are small arthrodial joints which articulate with the costal tuberosity on the transverse process of the thoracic vertebrae. CTJs are composed of oval-shaped facets with a major axis, vertical at the upper vertebrae and almost horizontal at the lower vertebrae. This position explains the different movements of the ribs: the cranial ribs move on the sagittal plane and the caudal ribs on the transverse plane. Read More

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Characterizing variations in dissolved organic matter (DOM) properties in Nansi Lake: a typical macrophytes-derived lake in northern China.

Environ Sci Pollut Res Int 2021 Jun 12. Epub 2021 Jun 12.

School of Environment and Planning, Liaocheng University, Road 1, Liaocheng, 252000, Hunan, China.

Nansi Lake is the largest lake along the eastern route of China's South-to-North Water Diversion Project (SNWDP). It is divided into the upper lake and the lower lake by a dam. By using UV-Vis spectroscopy, synchronous fluorescence (SF) spectroscopy, excitation-emission matrix and parallel factor analysis (EEM-PARAFAC), spatial, and temporal differences in the properties of dissolved organic matter (DOM) were found in the 2 areas of Nansi Lake under different hydrological conditions. Read More

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Outwelling of total alkalinity and dissolved inorganic carbon from the Hooghly River to the adjacent coastal Bay of Bengal.

Environ Monit Assess 2021 Jun 12;193(7):415. Epub 2021 Jun 12.

School of Marine Science, University of Maine, Orono, ME, USA.

The seasonal variability of the lateral flux of total alkalinity (TAlk) and dissolved inorganic carbon (DIC) of the tropical Hooghly estuary is analyzed in this work. In situ observations of water temperature, salinity, dissolved oxygen, TAlk, and pH were measured in four different stations of the Hooghly estuary. It was measured once every month during 2015-2016, and subsequently, DIC was estimated. Read More

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Constitutive Hedgehog/GLI2 signaling drives extracutaneous basaloid squamous cell carcinoma development and bone remodeling.

Carcinogenesis 2021 Jun 12. Epub 2021 Jun 12.

Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.

Uncontrolled activation of the Hedgehog (Hh) signaling pathway, operating through GLI transcription factors, plays a central role in the pathogenesis of cutaneous basal cell carcinoma and contributes to the development of several malignancies arising in extracutaneous sites. We now report that K5-tTA;tetO-Gli2 bitransgenic mice develop distinctive epithelial tumors within their jaws. These tumors consist of large masses of highly proliferative, monomorphous, basaloid cells with scattered foci of keratinization and central necrosis, mimicking human basaloid squamous cell carcinoma (BSCC), an aggressive upper aerodigestive tract tumor. Read More

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Efficacy of aqua-based plyometric exercises in the rehabilitation of patients with juvenile dermatomyositis: A randomized crossover pilot study.

Int J Rheum Dis 2021 Jun 12. Epub 2021 Jun 12.

Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt.

Background: Patients with juvenile dermatomyositis (JDM) experience muscle weakness, tiredness, and loss of energy, which restrict their abilities in performance of their daily living activities.

Objective: To explore the effect of aquatic-based plyometric (Aqua-PLYO) exercises on muscle strength, fatigue, and functional ability in patients with JDM.

Methods: This was a randomized, single-blind, crossover pilot study that included 16 patients with JDM (age 13. Read More

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Prescribing Antibiotics in Adults with Respiratory Tract Infections in Lebanon.

Int J Clin Pract 2021 Jun 12:e14514. Epub 2021 Jun 12.

Department of Family Medicine, American University of Beirut Medical Center (AUBMC, Beirut, Lebanon.

Background: Antibiotic resistance is a global concern that has significant health and economic burden. The inappropriate use of antibiotics is a major cause of antibiotic resistance; this includes both unnecessary and incorrect prescriptions. Most antibiotics are prescribed in primary care, mainly for respiratory tract infections. Read More

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Risk of Bleeding Associated with Antidepressant Drugs: The Competitive Impact of Antithrombotics in Quantitative Signal Detection.

Drugs Real World Outcomes 2021 Jun 11. Epub 2021 Jun 11.

Department of Psychiatry and Psychotherapy III, University of Ulm, Leimgrubenweg 12-14, 89075, Ulm, Germany.

Background: To date, disproportionality analysis has been unable to demonstrate the increased bleeding risk associated with antidepressant drugs, especially selective serotonin reuptake inhibitors.

Objective: We hypothesised that a potential signal for an increased bleeding risk may be mitigated by the effects of agents other than antidepressant drugs that are strongly associated with haemorrhages, especially antithrombotics. In addition, we investigated if the use of more specific search terms of the Medical Dictionary for Regulatory Activities facilitates the detection of signals. Read More

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A liver metastasis 7 years after resection of a low-risk duodenal gastrointestinal stromal tumor.

Clin J Gastroenterol 2021 Jun 11. Epub 2021 Jun 11.

Department of Surgery, National Hospital Organization, Higashihiroshima Medical Center, 513 Jike, Saijo-cho, Higashihiroshima, Hiroshima, 739-0041, Japan.

Duodenal gastrointestinal stromal tumors (dGISTs) are rare, and a lack of consensus exists regarding their treatment, particularly for recurrent disease. We herein report a rare case of liver metastasis 7 years after resection of a low-risk duodenal gastrointestinal stromal tumor. A 45-year-old woman revealed positive fecal occult blood. Read More

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Does general comorbidity impact the postoperative outcomes after surgery for large and giant petroclival meningiomas?

Neurosurg Rev 2021 Jun 12. Epub 2021 Jun 12.

Service de Neurochirurgie, CHU Nord, APHM-AMU, Marseille, France.

We assessed the role of the general condition of the patient in addition to usual anatomical reasoning to improve the prediction of personalized surgical risk for patients harboring a large and giant petroclival meningiomas. Single-center, retrospective observational study including adult patients surgically treated for a large and giant petroclival meningioma between January 2002 and October 2019 in a French tertiary neurosurgical skull-base center by one Neurosurgeon. Inclusion criteria were as follows: (1) histopathologically proven meningioma; (2) larger than 3 cm in diameter; (3) located within the upper two-thirds of the clivus, the inferior petrosal sinus, or the petrous apex around the trigeminal incisura, medial to the trigeminal nerve. Read More

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Traumatic cervical spine fracture patterns on CT: a retrospective analysis at a level 1 trauma center.

Emerg Radiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Radiology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis St, Boston, MA, 02115, USA.

Purpose: The purpose of our study was to determine common acute traumatic cervical spine fracture patterns on CT cervical spine (CTCS).

Methods: We retrospectively reviewed 1091 CTCS positive for traumatic fractures performed over a 10-year period at a level 1 trauma center. Fractures were classified by vertebral level, laterality, and anatomic location (anterior/posterior arch, body, odontoid, pedicle, facet, lateral mass, lamina, spinous process, transverse foramina, and transverse processes). Read More

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A modified transconjunctival technique for botulinum toxin chemodenervation of levator palpebrae superioris for corneal protection.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Cambridge University Hospitals, Cambridge, UK.

Background: Botulinum toxin (BTX) is useful for inducing temporary ptosis in patients with ocular surface disease. However, transcutaneous BTX often causes inadvertent superior rectus (SR) paresis. Furthermore, Muller's muscle is unaffected by transcutaneous BTX, resulting in lagophthalmos and incomplete ptosis. Read More

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GMP compliant isolation of mucosal epithelial cells and fibroblasts from biopsy samples for clinical tissue engineering.

Sci Rep 2021 Jun 11;11(1):12392. Epub 2021 Jun 11.

Cancer Institute, Department of Haematology, University College London, London, UK.

Engineered epithelial cell sheets for clinical replacement of non-functional upper aerodigestive tract mucosa are regulated as medicinal products and should be manufactured to the standards of good manufacturing practice (GMP). The current gold standard for growth of epithelial cells for research utilises growth arrested murine 3T3 J2 feeder layers, which are not available for use as a GMP compliant raw material. Using porcine mucosal tissue, we demonstrate a new method for obtaining and growing non-keratinised squamous epithelial cells and fibroblast cells from a single biopsy, replacing the 3T3 J2 with a growth arrested primary fibroblast feeder layer and using pooled Human Platelet lysate (HPL) as the media serum supplement to replace foetal bovine serum (FBS). Read More

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Selective control of the contact and transport between droplet pairs by electrowetting-on-dielectric for droplet-array sandwiching technology.

Sci Rep 2021 Jun 11;11(1):12355. Epub 2021 Jun 11.

Graduate Course of Science and Engineering, Ritsumeikan University, Kusatsu, 525-8577, Japan.

Methodological advances in on-chip technology enable high-throughput drug screening, such as droplet-array sandwiching technology. Droplet-array sandwiching technology involves upper and lower substrates with a droplet-array designed for a one-step process. This technology is, however, limited to batch manipulation of the droplet-array. Read More

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Environmental and diagenetic controls on the morphology and calcification of the Ediacaran metazoan Cloudina.

Sci Rep 2021 Jun 11;11(1):12341. Epub 2021 Jun 11.

School of GeoSciences, University of Edinburgh, James Hutton Road, Edinburgh, EH9 3FE, UK.

Cloudina is a globally distributed Ediacaran metazoan, with a tubular, funnel-in-funnel form built of thin laminae (ca. 1-10 μm). To what degree local environmental controlled morphology, and whether early diagenesis controlled the degree of calcification of Cloudina, is debated. Read More

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Stacking fault energy in concentrated alloys.

Nat Commun 2021 Jun 11;12(1):3590. Epub 2021 Jun 11.

Materials Science and Engineering, Ohio State University, Columbus, OH, USA.

We revisit the meaning of stacking fault energy (SFE) and the assumptions of equilibrium dissociation of lattice dislocations in concentrated alloys. SFE is a unique value in pure metals. However, in alloys beyond the dilute limit, SFE has a distribution of values depending on the local atomic environment. Read More

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Effect of Strength Versus Strength and Endurance Upper Limb Exercise Training in Patients With Chronic Obstructive Pulmonary Disease: A RANDOMIZED CLINICAL TRIAL.

J Cardiopulm Rehabil Prev 2021 Jun 10. Epub 2021 Jun 10.

Department of Health Sciences, School of Sciences, European University Cyprus, Nicosia, Cyprus (Drs Karagiannis and Savva and Ms Matheou); Aspetar, Orthopaedic and Sports Medicine Hospital, Doha, Qatar (Dr Korakakis); Respiratory Clinic, Nicosia General Hospital, Nicosia, Cyprus (Dr Adamide); Private Doctor, Nicosia, Cyprus (Dr Georgiou); Physiotherapy Department, Nicosia General Hospital, and Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus (Ms Prodromou); and School of Medicine, European University Cyprus, Nicosia, Cyprus (Dr Xanthos).

Purpose: Pulmonary rehabilitation (PR) including exercise training improves muscle strength, exercise capacity, and health-related quality of life in patients with chronic obstructive pulmonary disease (COPD). However, the evidence of the effect of upper limb exercise training (ULET) on activities of daily living (ADL) is sparse. This study investigated the effect of two different types of ULET on ADL in addition to standard PR. Read More

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Multidecadal poleward shift of the southern boundary of the Antarctic Circumpolar Current off East Antarctica.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

Institute of Low Temperature Science, Hokkaido University, Sapporo, Japan.

The southern boundary (SB) of the Antarctic Circumpolar Current, the southernmost extent of the upper overturning circulation, regulates the Antarctic thermal conditions. The SB's behavior remains unconstrained because it does not have a clear surface signature. Revisited hydrographic data from off East Antarctica indicate full-depth warming from 1996 to 2019, concurrent with an extensive poleward shift of the SB subsurface isotherms (>50 km), which is most prominent at 120°E off the Sabrina Coast. Read More

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Expanding the clinical phenotype and genetic spectrum of PURA-related neurodevelopmental disorders.

Brain Dev 2021 Jun 8. Epub 2021 Jun 8.

Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: PURA-related neurodevelopmental disorders (PURA-NDDs) include 5q31.3 deletion syndrome and PURA syndrome. PURA-NDDs are characterized by neonatal hypotonia, moderate to severe global developmental delay/intellectual disability (GDD/ID), facial dysmorphism, epileptic seizures, nonepileptic movement disorders, and ophthalmological problems. Read More

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Bioactive glass S53P4 to fill-up large cavitary bone defect after acute and chronic osteomyelitis treated with antibiotic-loaded cement beads: A prospective case series with a minimum 2-year follow-up.

Injury 2021 Jun 1. Epub 2021 Jun 1.

Trauma Service, Instituto de Ortopedia e Traumatologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, São Paulo, SP, Brazil.

Introduction: Bioactive glass S53P4 (BAG-S53P4) has been used in the treatment of osteomyelitis with excellent results. The aim of this study was to evaluate the clinical and radiographic results of patients treated with use of antibiotic-loaded cement beads, followed by bone defects filling using bioglass.

Methods: We treated a prospective series of patients presenting with acute or chronic osteomyelitis of a long bone of the upper or lower limb. Read More

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Logistic regression analysis on risk factors of augmented vertebra recompression after percutaneous vertebral augmentation.

J Orthop Surg Res 2021 Jun 11;16(1):374. Epub 2021 Jun 11.

Department of Spinal Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310005, Zhejiang, People's Republic of China.

Objective: To explore the high-risk factors of augmented vertebra recompression after percutaneous vertebral augmentation (PVA) in the treatment of osteoporotic vertebral compression fracture (OVCF) and analyze the correlation between these factors and augmented vertebra recompression after PVA.

Methods: A retrospective analysis was conducted on 353 patients who received PVA for a single-segment osteoporotic vertebral compression fracture from January 2017 to December 2018 in our department according to the inclusion criteria. All cases meeting the inclusion and exclusion criteria were divided into two groups: 82 patients in the recompression group and 175 patients in the non-compression group. Read More

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia.

BMC Pediatr 2021 Jun 11;21(1):275. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia. Read More

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