320,795 results match your criteria Upper Gastrointestinal Bleeding Surgical Treatment


Gastric Focal Neutrophil Infiltration and Wide Duodenal Gastric Foveolar Metaplasia Are Histologic Discriminative Markers for Crohn's Disease and Behçet's Disease.

Digestion 2018 Dec 12:1-10. Epub 2018 Dec 12.

Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.

Background/aims: Behçet's disease (BD) with intestinal lesions and Crohn's disease (CD) share clinical features. However, no report has compared the 2 diseases with regard to lesions of the upper gastrointestinal tract (UGT). We aimed to evaluate endoscopic and histologic findings of UGT in CD and BD. Read More

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December 2018

Efficacy and predictors of response to inhaled corticosteroid treatment for chronic cough.

Korean J Intern Med 2018 Dec 13. Epub 2018 Dec 13.

Lung Research Institute of Hallym University College of Medicine, Chuncheon, Korea.

Background/aims: Inhaled corticosteroids (ICS) are a treatment of choice for eosinophilic airway diseases, but their efficacy for other causes of chronic cough is controversial.

Methods: We conducted a prospective observational study to determine the ICS efficacy and clinical predictors of response to ICS in patients with upper airway cough syndrome (UACS) or unexplained chronic cough (UCC). Sixty-eight patients with UACS and 33 patients with UCC (duration of cough ≥ 8 weeks) were treated with ICS: 250 µg of fluticasone propionate or 400 µg of budesonide twice a day at physician's discretion. Read More

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December 2018

[Influence of HPV infection on cell cycle regulation in epithelial cell alterations of cervix uteri: Immunohistochemical and in situ hybridization observations].

Magy Onkol 2018 Dec 25;62(4):264-271. Epub 2018 Nov 25.

Daganatpatológiai Központ, Országos Onkológiai Intézet, Budapest, Hungary.

The HPV16 E6 DNA incorporation into the cervical epithelial cell genome was determined. In addition, using p16, p21 and p27 protein immunohistochemistry, we intended to present how the normal cell cycle machinery was disturbed in cervical epithelial cells. In CIN1 the epithelial cells are transformed into koilocytes, p16 is not expressed. Read More

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December 2018

Education and work participation among adults with congenital unilateral upper limb deficiency in Norway: A cross-sectional study.

PLoS One 2018 12;13(12):e0207846. Epub 2018 Dec 12.

Innlandet Hospital Trust, Department of Physical Medicine and Rehabilitation, Ottestad, Norway.

Objectives: To describe level of education and work participation among adults with congenital unilateral upper limb deficiency (CUULD) in Norway and to explore associations between work participation and demographic and clinical factors.

Methods: Cross-sectional study. In 2012, a postal questionnaire was sent to 186 persons with congenital limb deficiency (CLD), age ≥ 20 years, registered at the TRS National Resource Center for Rare Disorders. Read More

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December 2018

An integrated method for understanding the function of macro-lithic tools. Use wear, 3D and spatial analyses of an Early Upper Palaeolithic assemblage from North Eastern Italy.

PLoS One 2018 12;13(12):e0207773. Epub 2018 Dec 12.

Department of Oral and Maxillofacial Sciences, Diet and Ancient Technology Laboratory (DANTE), Sapienza University, Rome, Lazio, Italy.

The article presents an original analysis which combines use-wear, 3D modelling and spatial analyses to experimental archaeology in order to investigate Early Upper Palaeolithic flint-knapping gestures and techniques involving the use of macro-lithic tools. In particular, the methodological framework proposed in this paper was applied to the study of Protoaurignacian and Aurignacian macro-tools from Fumane Cave (Verona, Italy). Combining spatial analysis and use wear investigation, both at low and high magnifications, permitted the identification and detailed description of the use-related traces affecting both the hammerstones and retouchers which, at Fumane Cave, were used at different stages during flint tool production. Read More

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December 2018

Screen for modulators of atonal homolog 1 gene expression using notch pathway-relevant gene transcription based cellular assays.

PLoS One 2018 12;13(12):e0207140. Epub 2018 Dec 12.

R&D Alternative Discovery and Development, GlaxoSmithKline, Stevenage, Hertfordshire, United Kingdom.

Atonal homolog 1 (Atoh1) is a basic helix-loop-helix 9 (bHLH) transcription factor acting downstream of Notch and is required for the differentiation of sensory hair cells in the inner ear and the specification of secretory cells during the intestinal crypt cell regeneration. Motivated by the observations that the upregulation of Atoh1 gene expression, through genetic manipulation or pharmacological inhibition of Notch signaling (e.g. Read More

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December 2018

Measuring Work Related Physical and Mental Health Function: Updating the Work Disability Functional Assessment Battery (WD-FAB) using Item Response Theory.

J Occup Environ Med 2018 Dec 11. Epub 2018 Dec 11.

Tufts University, Department of Occupational Therapy, Medford, MA (Marfeo); University of Pittsburgh, School of Health and Rehabilitation Sciences, Department of Physical Therapy (McDonough); Boston University School of Public Health, Department of Health Law Policy and Management, Boston, MA (Ni, Peterik, Kazis); National Institutes of Health Rehabilitation Medicine Department, Bethesda, MD (Porcino, Rasch, Chan); VHA Office of Reporting, Analytics, Performance, Improvement and Deployment (RAPID) (Meterko).

Objective: To further improve measurement of work-related physical and mental health by updating the Work Disability Assessment Battery (WD-FAB).

Methods: Cross-sectional study with 1024 disability claimants and 1000 working age (21-66 years) adults in the United States. Developed new items to replenish the WD-FAB and analyzed using factor analysis and item response theory (IRT). Read More

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December 2018

The effect of task-oriented electromyography-triggered electrical stimulation of the paretic wrist extensors on upper limb motor function early after stroke: a pilot randomized controlled trial.

Int J Rehabil Res 2018 Dec 11. Epub 2018 Dec 11.

Department of Physical Medicine and Rehabilitation, University of Health Science, Diskapi Yildirim Beyazit Research and Training Hospital, Ankara, Turkey.

The combined effect of task-oriented motor training and electromyography (EMG)-triggered electrical stimulation (ES) has been examined in chronic stroke, but there are no published reports in patients with early stroke. Therefore, the purpose of this study was to determine the short-term and long-term effects of task-oriented EMG-triggered ES on upper limb motor function in acute/subacute stroke. Twenty-seven patients with stroke within the first 3 months after stroke onset were randomly allocated to an experimental group and a control group. Read More

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December 2018
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Mechanisms of disease: The endocrinology of obstructive sleep apnoea.

Eur J Endocrinol 2018 Dec 1. Epub 2018 Dec 1.

A Tahrani, University of Birmingham, Institute of Metabolism and Systems Research, Birmingham, United Kingdom of Great Britain and Northern Ireland.

Obstructive sleep apnoea (OSA) is a common disorder that is associated with serious co-morbidities with a negative impact on quality of life, life expectancy and health costs. As OSA is related to obesity and is associated with sleep disruption, increased inflammation and oxidative stress, it is not surprising that OSA has an impact on the secretion of multiple hormones and is implicated in the development of many endocrine conditions. On the other hand, many endocrine conditions that can affect obesity and/or upper airways anatomy and stability have been implicated in the development or worsening of OSA. Read More

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December 2018

Is anterior guidance a key factor on planning implant treatment for free-end missing in the posterior mandible?

J Oral Implantol 2018 Dec 12. Epub 2018 Dec 12.

1 Kyushu Dental University Department of Oral Reconstruction and Rehabilitation Kyushu Dental University.

To perform safe implant treatment, the anatomical structure and bone quality at implant placement sites are evaluated based on a patient's CT data, but there is no definite method to determine placement sites and the appropriate number of implants. The objective of this study was to investigate the influence of the number and arrangement of implants on the stress distribution in 3-unit posterior fixed partial dentures for the posterior mandible by mechanical analysis using the finite element method. Three-dimensional finite element analysis models were constructed from the CT data of a patient with missing mandibular teeth (Nos. Read More

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December 2018

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.

Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More

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December 2018

Phys-MAPS: a programmatic physiology assessment for introductory and advanced undergraduates.

Adv Physiol Educ 2019 Mar;43(1):15-27

Molecular, Cellular, and Developmental Biology, University of Colorado-Boulder , Boulder, Colorado.

We describe the development of a new, freely available, online, programmatic-level assessment tool, Measuring Achievement and Progress in Science in Physiology, or Phys-MAPS ( http://cperl.lassp.cornell. Read More

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COMPARISON BETWEEN THE ENDOSCOPIC FINDINGS AND THE HISTOLOGICAL DIAGNOSIS OF ANTRAL GASTRITES.

Arq Gastroenterol 2018 Jul-Sep;55(3):212-215

Universidade Federal de Juiz de Fora (UFJF), Programa de Pós-graduação em Saúde, MG, Brasil.

Background: Gastritis is a very common disorder that is widely distributed worldwide, representing one of the most prevalent pathological entities in Gastroenterology and Digestive Endoscopy.

Objective: This study aims to analyze the correlation between the endoscopic findings and the histological diagnosis of antral gastritis.

Methods: In this study, 92 reports of upper digestive endoscopy were performed between November 2014 and January 2015, including biopsy of the antral gastric mucosa, comparing the endoscopic and histological findings, which were classified according to the Sidney System. Read More

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January 2018
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Highly Efficient Fluorescent Organic Light-Emitting Devices Using a Luminescent Radical as the Sensitizer.

J Phys Chem Lett 2018 Dec 12. Epub 2018 Dec 12.

In traditional fluorescent organic light-emitting diodes (OLEDs), the upper limit of internal quantum efficiency (IQE) is only 25% because 75 % triplet excitons created on the fluorescent dyes are non-luminous. Here, luminescent radicals are proposed as the sensitizer. Under ideal conditions, electrons and holes firstly recombine on the sensitizer molecule to create doublet excitons, then through energy transfer to generate singlet excitons on the fluorescent dye, finally via radiative decay to emit light. Read More

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December 2018

Association Between Erosive Esophagitis and the Anthropometric Index in the General Korean Population

Authors:
Hyun Young Kim

Balkan Med J 2018 12 12. Epub 2018 Dec 12.

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam-si, Korea

Background: An association between obesity and gastroesophageal reflux disease (GERD) has been reported. However, previous studies have focused on obesity or central obesity.

Aims: The aim of this study was to investigate the association of anthropometric index and endoscopic erosive esophagitis (EE) in health check-up of Koreans. Read More

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December 2018

Isolated tension pneumoperitoneum following endobronchial ultrasound-guided transbronchial needle aspiration complicated by cardiac peri-arrest: A case report.

Monaldi Arch Chest Dis 2018 Dec 12;88(3):999. Epub 2018 Dec 12.

San Raffaele Scientific Institute, Department of Thoracic Surgery.

Transbronchial needle aspiration under endobronchial ultrasound guidance (EBUS-TBNA) is recommended for the diagnosis and staging of lung cancer. Major complications following EBUS-TBNA are uncommon. We report a case of isolated tension pneumoperitoneum following EBUS-TBNA under deep sedation in an 80-year-old male patient affected by a right hilar mass suspicious for lung cancer. Read More

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December 2018

Impact of Duodeno-Jejunal Bypass Liner (EndoBarrierTM) Implantation on Insulin Sensitivity in Patients with Type 2 Diabetes Mellitus (T2DM): A Study Protocol for a Pilot Trial.

Diabetes Ther 2018 Dec 11. Epub 2018 Dec 11.

Divisions of Endocrinology and Diabetology, Division of Gastroenterology and Hepatology, Medizinische Universitat Graz, Graz, Austria.

Introduction: A 60-cm endoscopically implantable duodenal-jejunal bypass liner (Endobarrier™, GI Dynamics, Lexington, MA, USA) has been introduced as a therapeutic option to support weight loss for a selected group of obese subjects with type 2 diabetes mellitus (T2DM). The sleeve prevents contact between chyme and the intestinal mucosa of the upper gastrointestinal tract. The primary aim of this study is to elucidate the changes in insulin sensitivity and beta-cell function after EndoBarrier™ implantation in obese patients with T2DM; changes in gut permeability and gut microbiome are also to be examined. Read More

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December 2018

Pancreaticoduodenectomy with Mesocaval Shunt for Locally Advanced Pancreatic Adenocarcinoma.

Ann Surg Oncol 2018 Dec 11. Epub 2018 Dec 11.

Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, 1400 Pressler, Unit 1484, Houston, TX, USA.

Introduction: Patients with locally advanced pancreatic cancer (LAPC) represent a challenging group to treat, given the involvement of major vascular structures. In selected patients with favorable biology, temporary mesocaval shunt can facilitate the resection and allow for a safer procedure with enhanced exposure to the superior mesenteric vessels.

Methods: We present a video of a pancreaticoduodenectomy (PD) with temporary mesocaval shunt with left internal jugular (LIJ) vein conduit. Read More

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December 2018

Lanadelumab for the Prophylactic Treatment of Hereditary Angioedema with C1 Inhibitor Deficiency: A Review of Preclinical and Phase I Studies.

BioDrugs 2018 Dec 12. Epub 2018 Dec 12.

Division of Rheumatology, Allergy and Immunology, University of California, San Diego, 8899 University Center Lane, Suite 230, San Diego, CA, 92122, USA.

Hereditary angioedema (HAE) with C1 esterase inhibitor (C1-INH) deficiency (C1-INH-HAE) is a rare disease characterized by diminished levels or dysfunctional activity of C1-INH, leading to dysregulated plasma kallikrein activity within the kallikrein-kinin pathway. Symptoms manifest as painful, potentially life-threatening swelling of subcutaneous tissues throughout the body and/or submucosal edema in the upper airway or gastrointestinal tract. Attacks recur with unpredictable frequency, intensity, and duration, placing a heavy burden on patients' daily lives. Read More

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December 2018

Determining a transitional scoring link between PROMIS® pediatric and adult physical health measures.

Qual Life Res 2018 Dec 11. Epub 2018 Dec 11.

Duke University, Durham, NC, USA.

Purpose: Having independent versions of the PROMIS® scales (for Pediatric and Adults) is problematic as scores cannot be evaluated longitudinally as individuals move from childhood into adulthood. The primary aim of this research project is to use item response theory (IRT) to develop a transitional scoring link (or "crosswalk") between the PROMIS adult and pediatric physical health measures.

Setting: Sample 1 was collected at 6 rehabilitation hospitals in the U. Read More

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December 2018

Correction to: Finger Length Ratios of Identical Twins with Discordant Sexual Orientations.

Arch Sex Behav 2018 Dec 11. Epub 2018 Dec 11.

Department of Psychology, University of Essex, Colchester, C04 3SQ, UK.

Readers should note that the confidence intervals for the effect of sexual orientation on 2D:4D in the left hand of female twins are incorrectly reported in Table 1 of this article. In particular, the upper limit of the confidence intervals is missing a minus sign. Read More

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December 2018

Fish whole-body selenium: interspecies translation experiment.

Environ Monit Assess 2018 Dec 12;191(1):17. Epub 2018 Dec 12.

CH2M, Inc., 2485 Natomas Park Drive, Suite 600, Sacramento, CA, 95833, USA.

The Total Maximum Daily Load (TMDL) for selenium in the freshwater drainages to Newport Bay, California, is being developed based on selenium concentration in the tissues of fish and bird eggs. This paper demonstrates the use of fish mesocosms and monitoring results to facilitate the comparisons of selenium contamination across fish species and areas of the watershed with differing fish assemblages. In this watershed, mosquitofish dominate across all the small, upper watershed drainages while sunfish family species dominate in deeper, ponded reaches of the lower watershed. Read More

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December 2018

Predictive factors for complications associated with penetrated fish bones outside the upper gastrointestinal tract.

Eur Arch Otorhinolaryngol 2018 Dec 11. Epub 2018 Dec 11.

Department of Otolaryngology-Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue 1095, Wuhan, 430030, China.

Purpose: To investigate predictive risk factors for complications associated with migrating fish bones in the surrounding tissue of upper gastrointestinal tract.

Methods: A retrospective analysis over 12 years was conducted of 45 cases of buried fish bones in the surrounding tissue of upper gastrointestinal tract with complications. Meanwhile, a control group, including 39 cases of prolonged buried fish bones in the surrounding tissue of upper gastrointestinal tract without complications, was set. Read More

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December 2018
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Tuck Jump Assessment as an Indicator for Upper Extremity Injury.

Sports Med Int Open 2018 Jul 6;2(4):E113-E116. Epub 2018 Sep 6.

School of Kinesiology, Auburn University, Auburn, United States.

The purpose of this study was to determine if tuck jumps can be used as a dynamic movement assessment to ascertain a previous history of upper extremity injury in an overhead throwing sport. Seventy-one youth baseball and softball athletes (28 baseball/43 softball; 12.41±2. Read More

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The Polar OH1 Optical Heart Rate Sensor is Valid during Moderate-Vigorous Exercise.

Sports Med Int Open 2018 Jun 17;2(3):E67-E70. Epub 2018 Jun 17.

California State University San Marcos, Kinesiology, San Marcos, United States.

Purpose: Traditional heart-rate monitoring through the use of electrocardiograms or chest-worn heart rate sensors can be challenging in certain sports or in field settings. New technologies, such as photoplethysmography (PPG), have enabled heart-rate monitoring at alternate sites. However, to date, the accuracy and validity of various PPG sensors has not been examined in detail. Read More

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Endoscopic suturing for management of peptic ulcer-related upper gastrointestinal bleeding: a preliminary experience.

Endosc Int Open 2018 Dec 10;6(12):E1439-E1444. Epub 2018 Dec 10.

Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.

Acute non-variceal upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging emergency managed by gastroenterologists. The proper role of endoscopic suturing on the management of PUD-related UGIB is unknown.  This is an international case series of patients who underwent endoscopic suturing for bleeding PUD. Read More

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December 2018

Effectiveness of the Oral Human Attenuated Rotavirus Vaccine: A Systematic Review and Meta-analysis-2006-2016.

Open Forum Infect Dis 2018 Nov 12;5(11):ofy292. Epub 2018 Nov 12.

GSK, Wavre, Belgium.

Background: Gastroenteritis caused by rotavirus accounts for considerable morbidity in young children. We aimed to assess the vaccine effectiveness (VE) of the oral rotavirus vaccine , as measured by laboratory-confirmed rotavirus infection after referral to hospital and/or emergency departments in children aged <5 years with gastroenteritis.

Methods: We performed a systematic search for peer-reviewed studies conducted in real-life settings published between 2006 and 2016 and a meta-analysis to calculate the overall VE, which was further discriminated through stratified analyses. Read More

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November 2018

subsp. , the cause of contagious caprine pleuropneumonia, comprises two distinct biochemical groups.

Open Vet J 2018 26;8(4):393-400. Epub 2018 Oct 26.

Consultant, The Oaks, Nutshell Lane, Upper Hale, Farnham, Surrey GU9 0HG, UK.

subsp. , the cause of the World Organisation of Animal Health- listed contagious caprine pleuropneumonia, is a member of the cluster which comprises five pathogenic mycoplasmas of ruminants. These mycoplasmas are closely related immunologically and genetically which can lead to difficulties for differential diagnosis. Read More

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October 2018

A Case of Upper Limb Osteomyelitis and Septic Arthritis Presenting as Pseudoparalysis in a Two-Week-Old.

Case Rep Pediatr 2018 12;2018:1796831. Epub 2018 Nov 12.

Trauma and Orthopaedics Department, Cambridge University Hospitals Trust, Cambridge, UK.

Pseudoparalysis presenting in infants is a rare manifestation, where infection and trauma are the principle differentials. We present a case of a two-week-old baby boy with pseudoparalysis who was initially diagnosed as Erb's palsy when presented in the emergency department and later re-presented with signs of sepsis. A later diagnosis of osteomyelitis of the humerus and septic arthritis of the shoulder was made. Read More

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November 2018

Paroxysmal Cold Hemoglobinuria in an Adult with Respiratory Syncytial Virus.

Case Rep Hematol 2018 13;2018:7586719. Epub 2018 Nov 13.

Division of Hematology and Medical Oncology, Department of Medicine, Mount Sinai Beth Israel, Mount Sinai Hospital, New York, NY, USA.

Paroxysmal cold hemoglobinuria (PCH) is a rare form of cold autoimmune hemolytic anemia first discovered in the early 20th century in adults with tertiary syphilis. Today, it is more commonly seen in children as a life-threatening anemia during a viral upper respiratory tract infection (URI). Although respiratory syncytial virus (RSV) has previously been reported to cause PCH in a child, herein we present the first documented case in an adult. Read More

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November 2018

Bilateral Cerebrovascular Stroke as an Initial Presenting Symptom of Moyamoya Disease.

Case Rep Crit Care 2018 13;2018:2591494. Epub 2018 Nov 13.

Lincoln Medical and Mental Health Center, 234 E 149Th St., Bronx, NY 10451, USA.

Moyamoya disease is a rare condition affecting the circle of Willis and its branching arteries. While the pathogenesis is unclear, it causes progressive occlusion of multiple cerebral vessels leading to severe strokes. We report a case of a 47-year-old Hispanic woman with HTN presented with altered mental status and bilateral upper and lower extremity weakness with dystonic-like upper extremity movement. Read More

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November 2018

Traditional Korean Medicine Treatment for Patients with Wilting Disorder: A Literature Review of In Vivo Studies.

Evid Based Complement Alternat Med 2018 13;2018:5601846. Epub 2018 Nov 13.

Department of Acupuncture & Moxibustion, Kyung Hee University Hospital at Gangdong, 149 Sangil-dong, Gangdong-gu, Seoul 134-727, Republic of Korea.

Wilting disorder is an abnormal condition characterized by weakness and paralysis of the upper and lower extremities. Pathogenesis and treatment target of the disorder are unclear; hence, allopathic treatment is generally used to relieve the symptoms. To investigate the treatment mechanism and effect of Traditional Korean Medicine (TKM) in patients with wilting disorder, we reviewed in vivo studies that focused on the effect of TKM on the main symptoms of wilting disorder and treatment of the diseases that can cause these symptoms. Read More

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November 2018

Correlation between Quantitative C-Urea Breath Test and Treatment Success in a Population-Based Cohort.

Gastroenterol Res Pract 2018 13;2018:5439539. Epub 2018 Nov 13.

Division of Gastroenterology, Rabin Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Background: There are continual efforts to identify factors which influence the success of first-line therapy for () infection. The C-urea breath test result (C13-UBT) utilizes urease activity and is a highly accurate diagnostic assay. We aimed to determine whether the magnitude of C13-UBT result is related to treatment success. Read More

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November 2018

Time Course of Upper Limb Function in Children with Unilateral Cerebral Palsy: A Five-Year Follow-Up Study.

Neural Plast 2018 14;2018:2831342. Epub 2018 Nov 14.

KU Leuven, University of Leuven, Department of Rehabilitation Sciences, Leuven, Belgium.

Knowledge on long-term evolution of upper limb function in children with unilateral cerebral palsy (CP) is scarce. The objective was to report the five-year evolution in upper limb function and identify factors influencing time trends. Eighty-one children (mean age 9 y and 11 mo, SD 3 y and 3 mo) were assessed at baseline with follow-up after 6 months, 1, and 5 years. Read More

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November 2018

Mitochondrial phylogeography of the Iberian endemic frog , with implications for its conservation.

Curr Zool 2018 Dec 27;64(6):755-764. Epub 2018 Jan 27.

Museo Nacional de Ciencias Naturales (MNCN-CSIC), Calle de José Gutiérrez Abascal, 2, Madrid, Spain.

Genetic characterization of species using phylogeographic approaches represents a basic reference to understand their evolutionary history as well as to identify conservation priorities to protect areas of particular interest regarding evolutionary potential. Even in well-studied regions such information is lacking for the majority of species, including many endemic species with reduced distribution ranges. We investigate the phylogeographic pattern of the Iberian frog , an endemic amphibian restricted to Central and North-Western Iberian Peninsula. Read More

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December 2018

Lower Performance in the Six-Minute Walk Test in Obese Youth With Cardiometabolic Risk Clustering.

Front Endocrinol (Lausanne) 2018 27;9:701. Epub 2018 Nov 27.

Department of Public Health, School of Medicine, University of Naples Federico II, Naples, Italy.

Physical fitness is an important index of health. Our aim was to assess whether cardiorespiratory and/or musculoskeletal components of physical fitness were associated with cardiometabolic risk clustering in obese youth, using adapted and validated field tests. We evaluated 252 children and adolescents (132 males, 120 females), mean age 10. Read More

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November 2018

A novel de novo mutation in a patient with Holt-Oram syndrome.

Appl Clin Genet 2018 23;11:157-162. Epub 2018 Nov 23.

Center for Research on Congenital Anomalies and Rare Diseases (CIACER), Department of Basic Medical Sciences, Universidad Icesi, Cali, Valle del Cauca, Colombia,

Holt-Oram syndrome (HOS) is an autosomal dominant disorder characterized by congenital cardiac defects and congenital deformities of the upper limbs. Herein, we report the case of a 2-year-old patient presenting with clinical diagnostic criteria of HOS with interatrial and interventricular communication associated with hip dysplasia and upper limb reduction composed of radial ray anomaly. A novel de novo, potentially pathogenic variant in the gene at NM_181486. Read More

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November 2018

Madelung's disease - progressive, excessive, and symmetrical deposition of adipose tissue in the subcutaneous layer: case report and literature review.

Diabetes Metab Syndr Obes 2018 26;11:819-825. Epub 2018 Nov 26.

Department of Surgery with Trauma, Orthopaedic and Urological Subunit, Independent Public Health Care Center of the Ministry of Interior and Administration in Lublin, Lublin, Poland,

Madelung's disease is a rare disorder described for the first time in the year 1846 by Brodie. It is characterized by the occurrence of progressive, excessive, and symmetrical deposits of adipose tissue in the subcutaneous layer. Most often, these changes concern the neck, the nape of the neck, arms, and upper back, giving the patients a specific, pseudoathletic appearance. Read More

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November 2018

Modified FOLFOX6 as a first-line treatment for patients with advanced gastric cancer with massive ascites or inadequate oral intake.

Onco Targets Ther 2018 23;11:8301-8307. Epub 2018 Nov 23.

Department of Gastroenterology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan,

Background: Oral fluoropyrimidine plus platinum is a standard first-line treatment for advanced gastric cancer (AGC). However, this treatment is problematic for AGC patients with massive ascites or inadequate oral intake. This study aimed at evaluating the efficacy and safety of modified oxaliplatin (L-OHP) with l-leucovorin (l-LV) and bolus/continuous infusion of 5-fluorouracil (5-FU) (mFOLFOX6) regimen for patients with massive ascites or inadequate oral intake. Read More

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November 2018

Multiple Gastrointestinal Cancers in a Single Patient-a Rare Clinical Entity.

Indian J Surg Oncol 2018 Dec 16;9(4):633-635. Epub 2018 May 16.

Department of Surgical Oncology, BLK Hospital, Rajinder Place, New Delhi, 110008 India.

Multiple gastrointestinal cancers in a single patient is a rare entity. In our study, we are showing the clinical presentation and management of these patients. A fifty-nine-year-old asthenic male (already treated case of metachronous colorectal cancer in 2008 and 2011) presented with complaints of generalized weakness and fatigue. Read More

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December 2018
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Decadal Experience of Renal Cell Carcinoma from a Tertiary Care Teaching Institute in North India.

Indian J Surg Oncol 2018 Dec 22;9(4):558-564. Epub 2018 Sep 22.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh India.

To study the current trends of renal cell carcinoma (RCC) in terms of demographic characteristics, clinical presentation, staging, mode of management, histopathology, and survival characteristics from a high volume tertiary care teaching institute in North India. We retrospectively reviewed the records of all patients of RCC between January 2006 and December 2015 and variables like age, gender, symptoms, tumor size/location/number, stage, type of surgery, histopathology, and survival characteristics were studied. One hundred forty-four patients were included in the study. Read More

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December 2018

infection in chronic kidney disease patients undergoing hemodialysis in Egypt.

J Parasit Dis 2018 Dec 19;42(4):630-635. Epub 2018 Oct 19.

4Department of Zoology, Faculty of Science, Damanhour University, Damanhûr, 21634 Egypt.

Patients with chronic renal failure are more susceptible to infections due to acquired immunodeficiency caused by uremia. Parasitic infections are one of the significant causes of morbidity and mortality in those patients, So we aimed to assess the prevalence of spp. and other protozoan infections in patients undergoing hemodialysis in Qena Governorate, Upper Egypt. Read More

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December 2018

Clinical factors associated with contact lens dropout.

Cont Lens Anterior Eye 2018 Dec 8. Epub 2018 Dec 8.

Centre for Ocular Research and Education (CORE), School of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.

Purpose: Contact lens (CL) dropout is estimated to be approximately equal to the number of new wearers per year, resulting in virtually no growth in the global CL market. The purpose of this study was to determine ocular and CL factors associated with CL dropout.

Methods: This five-site study recruited subjects 18-45 years of age who had ceased CL wear within the past 6-12 months due to discomfort. Read More

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December 2018

Supra-costal tubeless percutaneous nephrolithotomy is not associated with increased complication rate: a prospective study of safety and efficacy of supra-costal versus sub-costal access.

BMC Urol 2018 Dec 11;18(1):112. Epub 2018 Dec 11.

From the Division of Urology, Department of Surgery, Changhua Christian Hospital, 135, Nanxiao St., Changhua City, Changhua County, 500, Taiwan.

Background: To assess the morbidities of tubeless percutaneous nephrolithotomy (PCNL) using supra-costal access and re-evaluate traditional concept of increased complications with supra-costal access.

Methods: From January 2010 to December 2014, a single surgeon performed 118 consecutive one-stage fluoroscopic guided PCNL's for complex renal and upper ureteral stone. Our definition for complex renal stone is defined as partial or complete staghorn stone, multiple renal stones in more than 2 calyxes, obstructive uretero-pelvic stone > 2 cm, and a renal stone in single functional kidney. Read More

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December 2018

Design of protein-protein binding sites suggests a rationale for naturally occurring contact areas.

J Chem Theory Comput 2018 Dec 11. Epub 2018 Dec 11.

Molecular recognition is a critical process for many biological functions and consists in non-covalent binding of different molecules, such as protein-protein, antigen-antibody and many others. The host-guest molecules involved often show a shape complementarity, and one of the leading specification for molecular recognition is that the interaction must be selective, i.e. Read More

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December 2018

Delayed post-operative cardiac tamponade manifesting as cardiogenic shock.

J Cardiol Cases 2013 Dec 2;8(6):195-197. Epub 2013 Nov 2.

Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

We describe the case of a 32-year-old woman with a history of cardiac surgery two weeks previously who presented with an upper gastrointestinal bleed. She also had symptoms of syncope and abdominal pain, as well as elevated liver enzymes. She had cool, clammy extremities, bilateral lower extremity edema, and oliguria. Read More

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December 2013

A Churg-Strauss syndrome patient with myopericardial involvement.

J Cardiol Cases 2015 Feb 11;11(2):52-55. Epub 2014 Nov 11.

Department of Cardiology, Laiko General Hospital, Athens, Greece.

Churg-Strauss syndrome is a necrotizing vasculitis of small vessels characterized by upper and lower airway disease followed by peripheral eosinophilia and multiple organ involvement. Herein we present the case of a 45-year-old female patient with Churg-Strauss syndrome and myopericardial disease who improved upon cyclophosphamide treatment. Apart from discussing the characteristics of myopericardial disease in eosinophilic syndromes, we highlight the crucial role of cardiac imaging in the prompt recognition and management of such patients. Read More

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February 2015

A super-elderly case of abdominal aortic aneurysm associated with chronic disseminated intravascular coagulation.

J Cardiol Cases 2015 Feb 26;11(2):48-51. Epub 2014 Nov 26.

Department of Cardiovascular Medicine, Kobe Rosai Hospital, Kobe, Japan.

Chronic disseminated intravascular coagulation (DIC) is a well-known complication of aortic aneurysm. A 91-year-old Japanese woman was admitted to our hospital because of massive purpura of the lower limbs. The presence of abdominal aortic aneurysm (AAA) had been pointed out from the age of 80 years, and its diameter had gradually increased. Read More

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February 2015

STEMI complicated with serum sodium of 113 mmol/L from syndrome of inappropriate antidiuretic hormone secretion: How worse could it be?

J Cardiol Cases 2014 Nov 14;10(5):190-192. Epub 2014 Aug 14.

Albert Einstein Medical Center, Philadelphia, PA, USA.

Hyponatremia commonly occurs in acute coronary syndrome and has been recognized as a worse prognostic indicator in patients with ST-segment elevation myocardial infarction (STEMI). However STEMI with preexisting hyponatremia from syndrome of inappropriate antidiuretic hormone secretion (SIADH) has never been described in the literature. We describe a case of 59-year-old woman who presented with STEMI and received emergent percutaneous coronary intervention who also had SIADH with the lowest serum sodium measurement of 113 mmol/L. Read More

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November 2014

Catheter ablation of ventricular tachycardia associated with cardiac sarcoidosis: Targeting a low-voltage area with strict voltage criteria.

J Cardiol Cases 2014 Oct 28;10(4):159-161. Epub 2014 Jul 28.

Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan.

The usefulness of voltage mapping with strict voltage criteria for catheter ablation of postinfarction ventricular tachycardia (VT) has been reported but not for VT associated with cardiac sarcoidosis (CS). A 62-year-old man with CS was referred for catheter ablation of VT refractory to antiarrhythmic and immunosuppressive therapy. Voltage mapping during sinus rhythm using strict voltage criteria with an upper limit of the low-voltage area (LVA) of ≤0. Read More

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October 2014