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Ann Surg Oncol 2022 Jun 25. Epub 2022 Jun 25.

Department of Upper Abdominal Surgery, Center for Digestive Diseases, Karolinska University Hospital, Stockholm, Sweden.

Background: Recent research indicates long-term survival benefits of minimally invasive esophagectomy (MIE) compared with open esophagectomy (OE) for patients with esophageal and gastroesophageal junction (GEJ) cancers, but there is a need for more population-based studies.

Methods: We conducted a prospective population-based nationwide cohort study including all patients in Sweden diagnosed with esophageal or junctional cancer who underwent a transthoracic esophagectomy with intrathoracic anastomosis. Data were collected from the Swedish National Register for Esophageal and Gastric Cancer in 2006-2019. Read More

Aliment Pharmacol Ther 2022 Jul;56(2):338-339

Digestive Disease Research Center, Medical University of South Carolina, Charleston, South Carolina, USA.

Aliment Pharmacol Ther 2022 Jul;56(2):336-337

Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, Scotland.

Trans R Soc Trop Med Hyg 2022 Jun 24. Epub 2022 Jun 24.

Faculdade de Medicina da Universidade Federal de Minas Gerais, Avenida Professor Alfredo Balena, 190 - Santa Efigênia, Belo Horizonte, Minas Gerais, 30130-100, Brazil.

Background: Sarcopenia is a common complication of cirrhosis and an important predictor of morbimortality. We aimed to determine the prevalence of sarcopenia and its associated factors in hepatosplenic schistosomiasis (HSS) as well as to evaluate whether muscle mass and function are associated with variceal upper gastrointestinal bleeding (VUGIB) and previous splenectomy in subjects without other liver diseases.

Methods: We conducted a cross-sectional study including adults with HSS who underwent clinical, biochemical, anthropometric, muscle strength and physical performance evaluations and were submitted to bioelectrical impedance analysis and abdominal ultrasound. Read More

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Aparato Digestivo, Hospital Universitario San Agustín, España.

Clear cell renal cell carcinoma is the most common renal neoplasm in adults. It has a relatively slow growth pattern that delays diagnosis until the onset of local, paraneoplastic or metastasis-related manifestations, and an unpredictable behavior ranging from aggressive tumors with poor short-term prognosis to late recurrence cases where metastases are identified years after nephrectomy, the latter scenario being the subject of the case we herein report. Read More

Korean J Gastroenterol 2022 Jun;79(6):244-251

Department of Internal Medicine, Uijeongbu St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Uijeongbu, Korea.

Background/aims: Globally, the population aged 80 years or older is growing faster due to the rising life expectancy. Korea has already entered into an advanced aged society, and a post-aged society is expected in 2025. This study evaluated the patterns of gastrointestinal disease in the population aged 80 years or older during the recent decade in Korea. Read More

World J Gastrointest Surg 2022 May;14(5):506-513

Surgical Gastroenterology Unit, Department of Surgery, Groote Schuur Hospital, University of Cape Town, Cape Town 7925, Western Cape, South Africa.

Background: Aorto-oesophageal fistula (AOF) are uncommon and exceedingly rare after corrosive ingestion. The authors report a case of AOF after corrosive ingestion that survived. A comprehensive literature review was performed to identify all cases of AOF after corrosive ingestion to determine the incidence of this condition, how it is best managed and what the outcomes are. Read More

Cureus 2022 May 19;14(5):e25149. Epub 2022 May 19.

Gastroenterology and Hepatology, Cheikh Khalifa International University Hospital, Mohammed VI University of Health Sciences (UM6SS), Casablanca, MAR.

Upper gastrointestinal bleeding (UGIB) from variceal rupture is a serious condition that can be life-threatening in some cases. Usually, the main cause is portal hypertension in cirrhosis, but other etiologies like liver metastases can be also involved. We present the case of a 64-year-old woman, with a history of metastatic breast cancer, who was admitted for a massive UGIB due to ruptured esophageal varices related to portal hypertension. Read More

BMC Gastroenterol 2022 Jun 21;22(1):301. Epub 2022 Jun 21.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Background/aim: The ABC score is a new pre-endoscopic scoring system that was recently developed to accurately predict one-month mortality in upper and lower gastrointestinal bleeding (GIB). We aim to validate this new score on a cohort of Lebanese patients treated in a tertiary care center and to compare it to currently existing scores.

Methods: Adult patients admitted to the American University of Beirut Medical Center (AUBMC) with overt GIB between January 2013 and August 2020 were included. Read More

Gastroenterology 2022 Jun 18. Epub 2022 Jun 18.

Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB, Canada; Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada.

Gastrointest Endosc 2022 Jun 17. Epub 2022 Jun 17.

Endoscopy Center and Endoscopy Research Institute, Shanghai Collaborative Innovation Center of Endoscopy, Zhongshan Hospital, Fudan University, Shanghai, China. Electronic address:

Background And Aims: Endoscopic resection is a feasible treatment for gastrointestinal extraluminal tumors, but remains a challenging procedure with limited data. In this study, we assessed the safety and efficacy of endoscopic resection for extraluminal tumors in the upper gastrointestinal tract.

Methods: From May 2016 to December 2021, 109 patients undergoing endoscopic resection for extraluminal tumors in the upper gastrointestinal tract were retrospectively included. Read More

Ulster Med J 2022 May 15;91(2):95-97. Epub 2022 Jun 15.

Consultant Gastroenterologist, Daisy Hill.

A female in her 80's presented to our Emergency Department following a fall. She reported general malaise, weight loss and raised inflammatory markers. Background included renal cell carcinoma 21 years previous, managed with radical nephrectomy. Read More

World J Gastroenterol 2022 May;28(20):2243-2247

Gastroenterology and Endoscopy Unit, Ospedale G. Mazzini, Teramo 64100, Italy.

Background: Intramural duodenal hematoma is a rare condition described for the first time in 1838. This condition is usually associated with blunt abdominal trauma in children. Other non-traumatic risk factors for spontaneous duodenal haematoma include several pancreatic diseases, coagulation disorders, malignancy, collagenosis, peptic ulcers, vasculitis and upper endoscopy procedures. Read More

Appl Bionics Biomech 2022 10;2022:3342919. Epub 2022 Jun 10.

Department of Gastroenterology, Yantai Mountain Hospital, Yantai, China.

Objective: The aim of this study was to better understand the characteristics and etiology of acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) in recent years in this region and to provide evidence-based medical evidence.

Methods: 100 patients with acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) who met the clinical diagnostic criteria of ANVUGIB admitted to Suzhou First People's Hospital from January 2017 to December 2021 were analyzed, as well as the age difference and change rule. According to age, 100 patients were divided into young (18-39 years), middle-aged (40-59 years), and elderly (60 years and above), and the differences in the three groups were compared. Read More

Front Immunol 2022 3;13:840916. Epub 2022 Jun 3.

The Second Affiliated Hospital, Department of Digestive Internal Medicine, Hengyang Medical School, University of South China, Hengyang, China.

Introduction: Immune checkpoint inhibitors (ICIs) have now become the standard therapy for malignancies like non-small cell lung cancer and classical Hodgkin's lymphoma. ICIs are associated with unique immune-related adverse events (irAEs) caused by dysregulated immune activation. Treatment of lower gastrointestinal (GI) tract irAEs, such as colitis, is more common. Read More

World J Gastrointest Endosc 2022 May;14(5):351-353

Department of Anesthesiology, Pain Medicine and Critical Care, AIIMS, New Delhi 110029, Delhi, India.

Upper gastrointestinal bleeding is common and often needs timely intervention for optimal outcomes. Esophageal bleeding may occur due to local advancement of malignancy or bleeding from an arterio-oesophageal fistula. We discuss the management options available for such cases. Read More

Cureus 2022 May 16;14(5):e25059. Epub 2022 May 16.

Gastroenterology and Hepatology, Rutgers University New Jersey Medical School, Newark, USA.

Background Upper gastrointestinal bleeding (UGIB) has a high morbidity and mortality. Social deprivation is a risk factor for UGIB and is associated with anxiety. The primary pharmaceutical therapeutic agents for anxiety are selective serotonin reuptake inhibitors. Read More

J Crit Care 2022 Jun 14;71:154093. Epub 2022 Jun 14.

Toronto Western Hospital, Toronto, Ontario, Canada; Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada; Department of Medicine (Respirology), University Health Network, Toronto, Canada. Electronic address:

Purpose: Neurocritical care patients are at risk of stress-induced gastrointestinal ulceration. We performed a systematic review and meta-analysis of stress ulcer prophylaxis (SUP) in critically ill adults admitted with a primary neurologic injury.

Materials And Methods: We included randomized controlled trials (RCTs) comparing SUP with histamine-2-receptor antagonists (H2RAs) or proton pump inhibitors (PPIs) to placebo/no prophylaxis, as well as to each other. Read More

J Surg Case Rep 2022 Jun 14;2022(6):rjac278. Epub 2022 Jun 14.

Department of Surgery, Cavan General Hospital, Cavan, Ireland.

Lower gastrointestinal (GI) bleeding (LGIB) is a common surgical condition, which is frequently encountered in the emergency department. The most common origin of LGIB is from the colo-rectal region. However, in majority of cases where no apparent bleeding source is identified, small bowel is the area of concern. Read More

Frontline Gastroenterol 2022 25;13(4):303-308. Epub 2021 Aug 25.

Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK.

Objective: During the COVID-19 pandemic, we extended the low-risk threshold for patients not requiring inpatient endoscopy for upper gastrointestinal bleeding (UGIB) from Glasgow Blatchford Score (GBS) 0-1 to GBS 0-3. We studied the safety and efficacy of this change.

Methods: Between 1 April 2020 and 30 June 2020 we prospectively collected data on consecutive unselected patients with UGIB at five large Scottish hospitals. Read More

J Community Hosp Intern Med Perspect 2022 31;12(1):96-103. Epub 2022 Jan 31.

Department of Family and Community Medicine, Texas Tech Health Sciences Center, Lubbock, TX, USA.

Introduction: Acute esophageal necrosis (AEN) is an uncommon but fatal cause of upper gastrointestinal bleeding. The complex pathophysiology of the disorder provides multiple points for intervention. Therefore, it is important to discuss the many multifaceted aspects of the disease. Read More

World J Surg Oncol 2022 Jun 16;20(1):205. Epub 2022 Jun 16.

Department of Gastroenterology and Hepatology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Background: Testicular tumor is one of the common solid tumors in young men. Testicular choriocarcinoma is a non-spermatogonial germ cell tumor, which is the rarest of all testicular cancers. Choriocarcinoma usually shows bleeding at the metastatic site, while gastrointestinal involvement is rare. Read More

Rev Esp Enferm Dig 2022 Jun 15. Epub 2022 Jun 15.

Aparato Digestivo, Hospital Nuestra Señora del Prado.

An 85-year-old female patient with a history of melanoma 2 years ago, with anemia and signs of upper gastrointestinal bleeding. She underwent gastroscopy in which 4 ulcerated and pigmented lesions located in the body and subcardial region were recognized. The anatomopathological study confirmed the diagnosis of metastatic melanoma. Read More

Cureus 2022 May 9;14(5):e24846. Epub 2022 May 9.

General Surgery, Cardinal Tien Hospital, Taipei, TWN.

Gallstone ileus is a rare presentation of cholelithiasis, which usually impacts the narrowest part of the bowel, the ileocecal valve. This occurs as a result of a bilioenteric fistula where a gallstone passed through and entered the gastrointestinal tract. It is most commonly encountered in elder patients and predominantly in females. Read More

Case Rep Gastroenterol 2022 Jan-Apr;16(1):264-269. Epub 2022 Apr 21.

Head of Department of Gastroenterology, Hepatology and Endoscopy, King Hamad Univer-sity Hospital, Al-Muharraq, Bahrain.

Pseudomelanosis of the upper gastrointestinal tract is a rare diagnosis of undetermined significance, most commonly affecting the duodenum. Endoscopically, it is characterized by dark spickled pigmentation . Its development has been linked to certain conditions and medications. Read More

Clin Pract Cases Emerg Med 2022 May;6(2):173-176

Good Samaritan Hospital, Department of Emergency Medicine, West Islip, New York.

Introduction: Acute upper gastrointestinal bleeding is a common emergency presentation. The United States Centers for Disease Control and Prevention 2018 survey of emergency department (ED) visits reported 436,000 ED visits for unspecified gastrointestinal bleeding that year.

Case Report: We present the case of a submucosal duodenal pseudoaneurysm causing massive gastro-intestinal hemorrhage in a male on anticoagulation. Read More

An Pediatr (Engl Ed) 2022 May 19;96(5):402-409. Epub 2021 Mar 19.

Departamento de Pediatría, Facultad de Medicina, Universidad de Menufia, Shibin el-Kom, Egypt.

Introduction: Stress ulcer prophylaxis (SUP) is commonly used in Paediatric Intensive Care Units (PICUs). However, strong evidence for this practice is lacking and there is a dire need for paediatric randomized controlled trials (RCTs). Our aim was to assess the usefulness of SUP with omeprazole in critically ill children. Read More

Arch Bronconeumol 2021 Jul 21;57(7):498. Epub 2021 May 21.

Servicio de Neumología, Hospital Universitario 12 de Octubre, Madrid, Spain.

Trials 2022 Jun 13;23(1):491. Epub 2022 Jun 13.

Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.

Background: Endoscopic submucosal dissection (ESD) is widely used as an effective treatment of early gastric and esophageal tumors, as it is minimally invasive, safe, and convenient. Epigastric pain is a common complication of ESD. In the traditional cognition, the postoperative pain of ESD is not serious and does not attach too much attention. Read More

BMJ Open 2022 Jun 13;12(6):e057991. Epub 2022 Jun 13.

Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada

Introduction: Proton pump inhibitors (PPIs) are widely used for primary and secondary prevention of upper gastrointestinal bleeding. However, there remains controversy about the overall net clinical benefit of PPIs (omeprazole, rabeprazole, pantoprazole, lansoprazole) when coprescribed with direct oral anticoagulants (DOACs; dabigatran, rivaroxaban, apixaban, edoxaban). Our objective is to explore the risk of clinically relevant events, including bleeding, thromboembolic events and death, in patients prescribed DOACs while taking PPIs versus no PPI. Read More