Search Our Scientific Publications & Authors

Cancer Med 2021 Jun 11. Epub 2021 Jun 11.

Unit for Thrombosis and Drug Research, Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

Background: Direct oral anticoagulants (DOACs) may increase the risk of gastrointestinal (GI) bleeding in patients with atrial fibrillation (AF) and GI cancer compared with vitamin K antagonists (VKA).

Methods: We conducted a Danish nationwide cohort study comparing the bleeding risk associated with DOAC versus VKA in patients with AF and GI cancer. We calculated crude bleeding rates per 100 person-years (PYs) for GI and major bleeding. Read More

Med Clin (Barc) 2021 Jun 7. Epub 2021 Jun 7.

Servicio de Medicina Interna, Hospital Universitario Clínico San Cecilio, Granada, España.

Pacing Clin Electrophysiol 2021 Jun 10. Epub 2021 Jun 10.

Quebec Heart and Lung Institute, Laval University, Quebec City, Quebec, Canada.

Background: Gastrointestinal bleeding (GIB) is associated with a high recurrence rate and a prior GIB episode is common in real-world left atrial appendage closure (LAAC) recipients. The present study sought to evaluate the clinical characteristics and outcomes of patients with prior GIB undergoing LAAC, and to determine the factors associated with and clinical impact of GIB recurrence.

Methods: Multicenter study including 277 consecutive patients who underwent percutaneous LAAC and had prior GIB. Read More

Andes Pediatr 2021 Feb 22;92(1):104-109. Epub 2021 Feb 22.

Hospital Clínico san Borja Arriarán, Santiago, Chile.

Introduction: Meckel's diverticulum (MD) is the remnant of the vitelline duct (VD) also called omphalomesente ric duct and it is considered the most frequent gastrointestinal malformation. Most of the cases are asymptomatic and the diagnosis of this type is always a challenge.

Objective: To describe 3 sympto matic presentations of MD and to discuss its symptoms, signs, and possible diagnostic-therapeutic tools. Read More

Rev Med Chil 2021 Jan;149(1):132-136

Departamento de Cirugía Vascular y Endovascular, Pontificia Universidad Católica de Chile, Santiago, Chile.

Primary aortoenteric fistula is the spontaneous communication between the lumen of the aorta and a portion of the digestive tract. The most common cause is the erosion of an abdominal aortic aneurysm into the 3rd or 4th portion of the duodenum. It manifests clinically as gastrointestinal bleeding, with or without abdominal pain and a pulsatile abdominal mass on physical exam. Read More

United European Gastroenterol J 2021 Jun 8. Epub 2021 Jun 8.

Groupe Hospitalier Intercommunal Le Raincy-Montfermeil, Montfermeil, France.

Objectives: Patients who develop upper gastrointestinal bleeding (UGIB) while in hospital appear to have a poor prognosis. Our study aims at analysing the difference in outcome between in-patients (IPs) and out-patients presenting with variceal and non-variceal UGIB.

Methods: We conducted a multicentre prospective study by collecting data about variceal and non-variceal UGIB cases through 46 hospitals in France between November 2017 and October 2018. Read More

Ann Intern Med 2021 Jun 8. Epub 2021 Jun 8.

Beth Israel Deaconess Medical Center, Boston, Massachusetts (Z.K., T.M.B., R.B.B.).

Nonvariceal upper gastrointestinal bleeding is common, morbid, and potentially fatal. Cornerstones of inpatient management include fluid resuscitation; blood transfusion; endoscopy; and initiation of proton-pump inhibitor therapy, which continues in an individualized manner based on risk factors for recurrent bleeding in the outpatient setting. The International Consensus Group released guidelines on the management of nonvariceal upper gastrointestinal bleeding in 2019. Read More

S Afr J Surg 2020 Dec;58(4):204-209

Faculty of Health Sciences, University of Cape Town, South Africa and Medical Gastro-enterology, Groote Schuur Hospital, South Africa.

Background: Adherence is variable in clinical practice to consensus guidelines on the management of upper gastrointestinal bleeding. We aimed to assess the effect of a quality improvement program (QIP) on guideline adherence.

Methods: A QIP was undertaken over a two-month period. Read More

S Afr J Surg 2020 Dec;58(4):199-203

Department of Surgery, University of KwaZulu-Natal, South Africa and Department of Surgery, University of the Witwatersrand, South Africa.

Background: This review from a tertiary centre in South Africa aims to describe the spectrum and outcome of upper gastrointestinal bleeding (UGIB) and identify risk factors for surgical management and death.

Methods: This was a retrospective review of a prospectively entered database of all adults presenting with UGIB between December 2012 and December 2016. Demographics, presenting physiology, risk assessment scores, outcomes of endoscopy endo-therapy and surgery were reviewed. Read More

Front Public Health 2021 19;9:649624. Epub 2021 May 19.

Department of Epidemiology and Health Statistics, School of Public Health, Kunming Medical University, Kunming, China.

Studies on the economic burden of disease (EBD) can estimate the social benefits of preventing or curing disease. The majority of studies focus on the economic burden of a single or regional disease; however, holistic or national research is rare in China. Estimating the national EBD can provide evidence for policy makers. Read More

Can J Gastroenterol Hepatol 2021 21;2021:6672440. Epub 2021 May 21.

Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Saga University, Saga, Japan.

Background And Aims: The present study aimed to clarify the safety and efficacy of the noncessation method of antithrombotic agents after emergency endoscopic hemostasis in patients with nonvariceal upper gastrointestinal bleeding (UGIB).

Methods: In this multicenter, prospective, pilot study, we performed emergency endoscopic hemostasis for nonvariceal UGIB in patients taking antithrombotic agents and resumed the medications without a cessation period (group A). The clinical characteristics, types of antithrombotic agents, UGIB etiology, treatment outcome, and adverse events were evaluated. Read More

Cureus 2021 May 31;13(5):e15343. Epub 2021 May 31.

Internal Medicine, Wayne State University, Detroit Medical Center (DMC) Sinai Grace Hospital, Detroit, USA.

Gastric neuroendocrine tumors (GNETs) are rare and subdivided into type I, type II, and type III. Types I and II are gastrin-dependent and are usually benign, whereas type III is gastrin-independent and more aggressive. Type I accounts for 70-80% of all GNETs. Read More

BMC Gastroenterol 2021 Jun 6;21(1):250. Epub 2021 Jun 6.

Department of Gastroenterology, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, Beijing, 100053, China.

Background: Few studies have reported whether a biopsy in emergency gastroscopy (EG) increased the risk of rebleeding in patients with Forrest I acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) combined with suspected malignant gastric ulcer (SMGU). This study aims to conduct a multicenter retrospective cohort study using propensity score matching to verify whether a biopsy in EG increases the risk of rebleeding in patients diagnosed with Forrest I ANVUGIB combined with SMGU.

Methods: Using the data for propensity-matched patients, logistic regression models were fitted using rebleeding as the dependent variable. Read More

Asian J Endosc Surg 2021 Jun 5. Epub 2021 Jun 5.

Department of Surgery, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan.

A 29-year-old male patient underwent laparoscopic sleeve gastrectomy (LSG) for morbid obesity and was discharged without any complications. Thirteen months later, he visited the emergency room with epigastric pain. A few hours before onset, he had had a larger-than-usual meal and vomited afterwards. Read More

Rev Gastroenterol Peru 2020 Oct-Dec;40(4):342-345

Clínica Medellín. Medellín, Colombia.

Gastrointestinal tract duplications are rare congenital malformations that can affect any segment of the digestive tract. They usually occur in the first two years of life with symptoms of poor weight gain and palpable abdominal mass or may be asymptomatic until adulthood. We report the case of a 37-year-old male patient who was evaluated for epigastralgia and a history of upper gastrointestinal bleeding. Read More

Int J Gen Med 2021 26;14:2079-2086. Epub 2021 May 26.

Department of Spleen and Stomach Diseases, The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangzhou, Guangdong Province, People's Republic of China.

Objective: We aimed to establish and evaluate a time series model for predicting the seasonality of acute upper gastrointestinal bleeding (UGIB).

Methods: Patients with acute UGIB who were admitted to the Emergency Department and Gastrointestinal Endoscopy Center of Guangdong Provincial Hospital of Traditional Chinese Medicine from January 2013 to December 2019 were enrolled in the present study. The incidence trend of UGIB was analyzed by seasonal decomposition method. Read More

Transplant Cell Ther 2021 May 30. Epub 2021 May 30.

Department of Blood and Marrow Transplant and Cellular Immunotherapy. Moffitt Cancer Center. Tampa, FL; Department of Oncologic Sciences, University of South Florida Morsani College of Medicine, Tampa, FL. Electronic address:

Background: CD19 chimeric antigen receptor (CAR) T cell therapy with axicabtagene ciloleucel (axi-cel) or tisagenlecleucel (tisa-cel) is approved for the standard of care treatment of relapsed or refractory large B cell lymphoma (LBCL). Patients with LBCL involving the gastrointestinal (GI) tract are at risk of perforation after lymphoma-directed therapy. The outcomes of CAR T cell therapy in patients with GI involvement have not been reported. Read More

BMC Gastroenterol 2021 Jun 1;21(1):246. Epub 2021 Jun 1.

Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Background: Small intestine duplication cysts (SIDCs) are rare congenital anatomical abnormalities of the digestive tract and a rare cause of hematochezia.

Case Presentation: We describe an adult female presented with recurrent hematochezia. The routine gastric endoscope and colonic endoscope showed no positive findings. Read More

Am Surg 2021 Jun 1:31348211023461. Epub 2021 Jun 1.

Department of Surgery, 12343Texas Tech University Health Sciences Center, Lubbock, TX, USA.

Chronic sequelae of COVID-19 remain undetermined. We report a case of postinfection sequelae in a patient presenting with subacute obstruction 2 months after COVID-19 infection. A 34-year-old man with a prior prolonged hospital stay due to COVID-19 complicated by upper gastrointestinal (GI) bleed presented with subacute obstruction and failure to thrive. Read More

J Can Assoc Gastroenterol 2021 Jun 24;4(3):156-162. Epub 2020 Oct 24.

Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted endoscopy services and education worldwide. This study aimed to characterize the impact of COVID-19 on gastroenterology trainees in Canada.

Methods: An analysis of Canadian respondents from the international EndoTrain survey, open from April 11 to May 2 2020 and distributed by program directors, trainees, and national and international gastroenterology societies' representatives, was completed. Read More

GE Port J Gastroenterol 2021 Apr 16;28(3):193-197. Epub 2020 Sep 16.

Gastroenterology Department, Hospital Garcia de Orta, Almada, Portugal.

Introduction: Dieulafoy's lesion (DL) is a rare but important cause of acute, severe, life-threatening, and recurrent upper gastrointestinal bleeding (UGIB). It is frequently difficult to diagnose DL with upper GI endoscopy (UGIE), and endoscopic ultrasonography (EUS) may be valuable. There are only 2 reported bleeding cases caused by two synchronous DL but no reported cases of two metachronous DL. Read More

PeerJ 2021 20;9:e11468. Epub 2021 May 20.

Department of Immunology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia.

Background: Gouty arthritis is a disease of global burden in which defective metabolism of uric acid causes arthritis. Gouty arthritis or medications used for its treatment may lead to uric acid-associated complications such as upper gastrointestinal bleeding (UGIB) and renal impairment.

Methods: In this cross-sectional study with retrospective record review, 403 established gouty arthritis patients were recruited to determine the incidence of UGIB and associated factors among gout patients who were on regular nonsteroidal anti-inflammatory drugs (NSAIDs). Read More

J Pediatr Hematol Oncol 2021 May 31. Epub 2021 May 31.

Fujian Provincial Key Laboratory on Hematology, Department of Pediatric Hematology Fujian Provincial Key Laboratory on Hematology, Fujian Institute of Hematology, Fujian Medical University Union Hospital, Fujian, PR China.

Surg Radiol Anat 2021 May 28. Epub 2021 May 28.

Department of Radiology, Albert Einstein College of Medicine/NYC Health + Hospitals - Jacobi Medical Center, The Bronx, NY, USA.

Purpose: Anatomic variants of the celiac trunk and superior mesenteric artery are common, thus knowledge of these variants is important for preoperative planning of abdominal surgery and interventional procedures.

Methods: We report a rare anatomic variant of replaced proper hepatic and gastroduodenal arteries discovered upon CT angiography and diagnostic angiogram.

Results: Emergent angiogram performed on a 61-year-old male who presented with signs and symptoms of upper gastrointestinal hemorrhage revealed a rare variant of an absent common hepatic artery and its branches with aberrant origins. Read More

World J Clin Cases 2021 May;9(15):3689-3695

Department of Hospital Medicine, Kangwon National University Hospital , Chuncheon-si 24289, South Korea.

Background: Clopidogrel is a platelet aggregation inhibitor used for the management of cardiovascular disease. While antiplatelet therapy decreases cardiovascular events after successful coronary drug-eluting stenting, it increases the risk of gastrointestinal (GI) bleeding. About 20% of the patients who take clopidogrel exhibit resistance to the drug. Read More

World J Clin Cases 2021 May;9(15):3576-3585

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu 42415, South Korea.

Background: The surge of coronavirus disease 2019 (COVID-19) patients has markedly influenced the treatment policies of tertiary hospitals because of the need to protect medical staff and contain viral transmission, but the impact COVID-19 had on emergency gastrointestinal endoscopies has not been determined.

Aim: To compare endoscopic activities and analyze the clinical outcomes of emergency endoscopies performed before and during the COVID-19 outbreak in Daegu, the worst-hit region in South Korea.

Methods: This retrospective cohort study was conducted on patients aged ≥ 18 years that underwent endoscopy from February 18 to March 28, 2020, at a tertiary hospital in Daegu. Read More

Ann Palliat Med 2021 May 12;10(5):5494-5501. Epub 2021 May 12.

Department of Neurology, Affiliated Hospital of Jiangnan University, Wuxi, China.

Background: Upper gastrointestinal bleeding (UGIB) is a common complication of acute ischemic stroke (AIS), but the effect of UGIB on the prognosis of middle-aged AIS patients is not clear.

Methods: Patients with AIS admitted to our hospital from January 2011 to December 2015 were eligible to be included in this study. All included patients were divided into UGIB and non-UGIB groups. Read More

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211020672

Augusta University, Augusta, GA, USA.

Odontogenic bacteremia, most commonly involving gram-positive oral flora, can result from daily self-care practices or professional dental procedures. Though usually transient and quickly cleared by the immune system, the presence of periodontal disease increases the frequency of exposure and risk of persistence of oral-systemic infections. Comorbidities such as asplenia, alcoholism, and immunocompromise increase the risk of complications of hematogenous spread and severe systemic illness. Read More

J Family Med Prim Care 2021 Mar 8;10(3):1431-1436. Epub 2021 Apr 8.

Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background: Upper gastrointestinal (UGI) bleeding is a common presentation to the Emergency Department (ED), and is associated with re-bleeding and significant mortality. Although several studies have described etiology and outcome of UGI bleeding, few have been done in the EDs.

Materials And Methods: This prospective observational cohort study included all patients presenting with hematemesis or melena, between June 2016 and January 2017 to the ED. Read More

Cureus 2021 Apr 21;13(4):e14615. Epub 2021 Apr 21.

Gastroenterology, University of Nevada Las Vegas School of Medicine, Las Vegas, USA.

Transarterial angiographic embolization is a highly effective, safe treatment for non-variceal upper gastrointestinal bleeding refractory to endoscopic intervention. However, intraluminal coil migration is a possible complication. Coil migration, while usually a self-limiting process, can lead to significant rebleeding. Read More