20,378 results match your criteria Upper Gastrointestinal Bleeding


Gastrointestinal Stromal Tumor: GIST Another Duodenal Ulcer.

Ochsner J 2020 ;20(2):236-238

Division of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL.

Gastrointestinal stromal tumors (GISTs), although exceedingly rare, are the most common mesenchymal tumors in the gastrointestinal (GI) tract. GISTs are often asymptomatic; approximately 10% are found incidentally on imaging or endoscopy for other indications, although GI bleeding, intestinal obstruction, and perforation can occur. We present a case of upper GI bleeding from a duodenal GIST. Read More

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http://dx.doi.org/10.31486/toj.18.0167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310177PMC
January 2020

Logistic regression analysis of risk factors for upper gastrointestinal bleeding induced by PCI in combination with double antiplatelet therapy for STEMI patients.

Authors:
B Tang S Xiao

Acta Gastroenterol Belg 2020 Apr-Jun;83(2):245-248

Department of Cardiology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou, China.

Objective: To analyze the risk factors for upper gastrointestinal bleeding (UGIB) in patients with ST-segment elevation myocardial infarction (STEMI) during double antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI).

Methods: A total of 388 patients treated from January 2015 to September 2017 due to STEMI were selected. Thirty-two cases of UGIB occurring during DAPT after PCI were included as a UGIB group, and another 356 cases without UGIB were set as a control group. Read More

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Current role of cyanoacrylate glue transcatheter embolization in the treatment of acute nonvariceal gastrointestinal bleeding.

Expert Rev Gastroenterol Hepatol 2020 Jun 30. Epub 2020 Jun 30.

Department of Vascular and Interventional Radiology, Image-Guided Therapy Center, François-Mitterrand University Hospital , Dijon, France.

Introduction: Over the past three decades, transcatheter arterial embolization (TAE) has become the first-line therapy for the management of acute nonvariceal gastrointestinal bleeding (NVGIB) that is refractory to endoscopic hemostasis. Advances in catheter-based techniques and newer liquid embolic agents, as well as recognition of the effectiveness of minimally invasive treatment options, have expanded the role of interventional radiology in the treatment of acute NVGIB. Many embolic agents have been used successfully. Read More

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http://dx.doi.org/10.1080/17474124.2020.1790355DOI Listing

Gastric Inflammatory Fibroid Polyp: A Rare Cause of Occult Upper Gastrointestinal Bleeding.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620936840

Cleveland Clinic Florida, Weston, FL, USA.

Inflammatory fibroid polyps (IFPs) are rare mesenchymal lesions that can arise throughout the gastrointestinal tract. These tumors represent less than 0.1% of all gastric polypoid lesions and are frequently found incidentally on endoscopic evaluation. Read More

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http://dx.doi.org/10.1177/2324709620936840DOI Listing

Stress ulcer prophylaxis versus placebo-a blinded randomized control trial to evaluate the safety of two strategies in critically ill infants with congenital heart disease (SUPPRESS-CHD).

Trials 2020 Jun 29;21(1):590. Epub 2020 Jun 29.

Harvard Medical School, Boston, MA, USA.

Background: Critically ill infants with congenital heart disease (CHD) are often prescribed stress ulcer prophylaxis (SUP) to prevent upper gastrointestinal bleeding, despite the low incidence of stress ulcers and limited data on the safety and efficacy of SUP in infants. Recently, SUP has been associated with an increased incidence of hospital-acquired infections, community-acquired pneumonia, and necrotizing enterocolitis. The objective of this pilot study is to investigate the feasibility of performing a randomized controlled trial to assess the safety and efficacy of withholding SUP in infants with congenital heart disease admitted to the cardiac intensive care unit. Read More

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http://dx.doi.org/10.1186/s13063-020-04513-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322718PMC

Outcomes of Hemospray therapy in the treatment of intraprocedural upper gastrointestinal bleeding post-endoscopic therapy.

United European Gastroenterol J 2020 Jun 26:2050640620938549. Epub 2020 Jun 26.

Division of Surgery and Interventional Science, University College London (UCL), London, UK.

Introduction: With increasing advances in minimally invasive endoscopic therapies and endoscopic resection techniques for luminal disease, there is an increased risk of post-procedure bleeding. This can contribute to significant burden on patient's quality of life and health resources when reintervention is required. Hemospray (Cook Medical, North Carolina, USA) is a novel haemostatic powder licensed for gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1177/2050640620938549DOI Listing

Prescribers' perceptions of benefits and limitations of direct acting oral anticoagulants in non-valvular atrial fibrillation.

Pharm Pract (Granada) 2020 Apr-Jun;18(2):1936. Epub 2020 Jun 13.

PhD. College of Pharmacy, QU Health, Qatar University. Doha (Qatar).

Background: There is an acknowledged lack of robust and rigorous research focusing on the perspectives of those prescribing direct acting oral anticoagulants (DOACs) for non-valvular atrial fibrillation (AF).

Objective: The objective was to describe prescribers' experiences of using DOACs in the management of non-valvular AF, including perceptions of benefits and limitations.

Methods: A cross-sectional survey of prescribers in a remote and rural area of Scotland. Read More

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http://dx.doi.org/10.18549/PharmPract.2020.2.1936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308911PMC

Giant splenic artery aneurysm presenting with massive upper gastrointestinal bleeding: A case report and review of literature.

World J Gastroenterol 2020 Jun;26(22):3110-3117

Division of General Surgery, Department of Surgery, Madonna delle Grazie Hospital, Matera 75100, Italy.

Background: Splenic artery aneurysm (SAA) and pseudoaneurysm are rare vessel's lesions. Pseudoaneurysm is often symptomatic and secondary to pancreatitis or trauma. True SAA is the most common aneurysm of visceral vessels. Read More

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http://dx.doi.org/10.3748/wjg.v26.i22.3110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304111PMC

Prealbumin and D-dimer as Prognostic Indicators for Rebleeding in Patients with Nonvariceal Upper Gastrointestinal Bleeding.

Dig Dis Sci 2020 Jun 24. Epub 2020 Jun 24.

Department of Digestive Diseases, Huashan Hospital, Fudan University, 12# Middle Wulumuqi Road, Shanghai, 200040, People's Republic of China.

Background: Determining the risk stratification of nonvariceal upper gastrointestinal bleeding (NVUGIB) plays a vital role in treating upper gastrointestinal bleeding (UGIB). Traditional scores like Glasgow-Blatchford score (GBS), Rockall score (RS), and AIMS65 score have been widely utilized in UGIB practice, however exhibiting limited practical use due to relative lack of user-friendly characters. Prealbumin as a nutritional indicator and d-dimer as a fibrinolytic activity monitor, are generally used to evaluate the overall nutritional and fibrinolytic condition in UGIB patients. Read More

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http://dx.doi.org/10.1007/s10620-020-06420-1DOI Listing

Aorto-esophageal fistula: successful open surgical management of two cases.

J Surg Case Rep 2020 Jun 17;2020(6):rjaa114. Epub 2020 Jun 17.

Department of Cardiac Anesthesia, AMRI Hospitals, 16 and 17 JC Block, Bidhannagar, Salt Lake, Kolkata 700098, West Bengal, India.

An aorto-esophageal fistula (AEF) is a rare yet life-threatening cause of upper gastrointestinal bleeding. We report our experience with open surgical management of two cases of AEF. Both cases presented with almost identical presentations: hematemesis and hemodynamic instability. Read More

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http://dx.doi.org/10.1093/jscr/rjaa114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7299603PMC

British Society of Gastroenterology (BSG)-led multisociety consensus care bundle for the early clinical management of acute upper gastrointestinal bleeding.

Frontline Gastroenterol 2020 27;11(4):311-323. Epub 2020 Mar 27.

Department of Gastroenterology, Glasgow Royal Infirmary, Glasgow, UK.

Medical care bundles improve standards of care and patient outcomes. Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency which has been consistently associated with suboptimal care. We aimed to develop a multisociety care bundle centred on the early management of AUGIB. Read More

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http://dx.doi.org/10.1136/flgastro-2019-101395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307267PMC

[Guidelines for Non-variceal Upper Gastrointestinal Bleeding].

Korean J Gastroenterol 2020 Jun;75(6):322-332

Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.

Non-variceal upper gastrointestinal bleeding (NVUGIB) refers to bleeding that develops in the gastrointestinal tract proximal to the ligament of Treitz. NVUGIB is an important cause for visiting the hospital and is associated with significant morbidity and mortality. Although European and Asian-Pacific guidelines have been published, there has been no previous guidelines regarding management of NVUGIB in Korea. Read More

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http://dx.doi.org/10.4166/kjg.2020.75.6.322DOI Listing

Efficacy and safety of endoscopic submucosal tunnel dissection vs endoscopic submucosal dissection for early upper gastrointestinal superficial precancerous lesions and tumors: a meta-analysis.

J Dig Dis 2020 Jun 24. Epub 2020 Jun 24.

Department of Gastroenterology and Hepatology, West China Hospital of Sichuan University, Chengdu, China.

Objective: Endoscopic submucosal tunnel dissection (ESTD), which is a new treatment for upper gastrointestinal superficial precancerous lesions and tumors has been proposed in recent years. However, compared with endoscopic submucosal dissection (ESD), the safety and efficacy of ESTD for treating these lesions are still uncertain. The aim of this meta-analysis was to compare the efficacy and safety of these two endoscopic procedures for the treatment of superficial upper gastrointestinal superficial precancerous lesions and tumors. Read More

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http://dx.doi.org/10.1111/1751-2980.12915DOI Listing

Gastric ulcer due to mucormycosis in a critical patient.

Rev Esp Enferm Dig 2020 Jun 24;112. Epub 2020 Jun 24.

Aparato Digestivo, Hospital General Universitario Morales Meseguer , España.

We have read the article published by Sánchez-Velázquez P et al., which described a clinical case of gastrointestinal hemorrhage secondary to gastric ulcer due to Mucor. We present a similar clinical case, as an example of one identified by gastroscopy. Read More

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http://dx.doi.org/10.17235/reed.2020.6636/2019DOI Listing

[Design and application of a new gastrointestinal nutrition pipeline].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2020 May;32(5):611-612

Department of Intensive Care Unit, the First People's Hospital of Fuyang District, Hangzhou 311400, Zhejiang, China. Corresponding author: Tang Weidong, Email:

Gastrointestinal nutrition tube is a special gastrointestinal tube designed for enteral nutrition, diagnosis, treatment and monitoring in severe patients. Clinically, it is inserted into patients' stomach for flushing, provide nutrition through stomach, duodenum or jejunum, and decompress gastrointestinal tract. It also can be used for gastric drainage, gastric juice pH value determination, and early diagnosis and treatment for stomach bleeding and other symptoms. Read More

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http://dx.doi.org/10.3760/cma.j.cn121430-20200327-00236DOI Listing

Gastrolithiasis with incomplete intestinal obstruction in the perioperative period of percutaneous transluminal coronary intervention: one case report.

Ann Palliat Med 2020 Jun 15. Epub 2020 Jun 15.

First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Gastrolithiasis is one of the uncommon clinical diseases with low incidence and its clinical manifestations are not typical. It is easy to be ignored when combined with other medical diseases. In this paper we present a case of gastrolithiasis just after percutaneous transluminal coronary intervention (PCI), the patient suffered from unexplained persistent abdominal distention and pain with gastric retention, nausea and vomiting. Read More

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http://dx.doi.org/10.21037/apm-20-467DOI Listing

[Analysis of survival and prognosis of Siewert Ⅱ/Ⅲ esophagogastric junction adenocarcinoma patients with non-operative acute upper gastrointestinal hemorrhage].

Authors:
L Tian L Yu

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1881-1885

Department of Comprehensive Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To analyze the clinical characteristics and risk factors of non-operative acute upper gastrointestinal hemorrhage in patients with adenocarcinoma of the esophagogastric junction. The clinical diagnosis and treatment data of patients with adenocarcinoma of esophagogastric junction with non-operative acute upper gastrointestinal hemorrhage admitted to Cancer Hospital of Chinese Academy of Medical Sciences from 2004 to 2018 were collected retrospectively, and the survival of patients was followed up by telephone. SPSS software was used for database establishment and analysis. Read More

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http://dx.doi.org/10.3760/cma.j.cn112137-20200404-01082DOI Listing

AGA Clinical Practice Update on Endoscopic Therapies for Non-Variceal Upper Gastrointestinal Bleeding: Expert Review.

Gastroenterology 2020 Jun 20. Epub 2020 Jun 20.

Division of Gastroenterology, McGill University, Montreal, Quebec, Canada.

Description: The purpose of this AGA Institute Clinical Practice Update is to review the available evidence and expert recommendations regarding the use of endoscopic therapies in treating patients with non-variceal upper GI bleeding.

Methods: This expert review was commissioned and approved by the AGA Institute Clinical Practice Updates Committee (CPUC) and the AGA Governing Board to provide timely guidance on a topic of high clinical importance to the AGA membership, and underwent internal peer review by the CPUC and external peer review through standard procedures of Gastroenterology. This review is framed around the 10 best practice advice points agreed upon by the authors, which reflect landmark and recent published manuscripts in this field. Read More

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http://dx.doi.org/10.1053/j.gastro.2020.05.095DOI Listing

Endoscopic projection of the gastroduodenal artery: Anatomical implications for bleeding management.

Ann Anat 2020 Jun 18;232:151560. Epub 2020 Jun 18.

University Clinic for Visceral, General and Transplant Surgery, University Hospital Tübingen, Tübingen, Germany. Electronic address:

Introduction: Peptic ulcers account for 50% of upper gastrointestinal bleeding incidents. Bleedings from large vessels, such as the gastroduodenal artery, are associated with increased mortality. Ulcers located on the posterior wall of the duodenum show the highest risk for erosion of the gastroduodenal artery. Read More

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http://dx.doi.org/10.1016/j.aanat.2020.151560DOI Listing

Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.

Authors:

Lancet 2020 Jun;395(10241):1927-1936

Background: Tranexamic acid reduces surgical bleeding and reduces death due to bleeding in patients with trauma. Meta-analyses of small trials show that tranexamic acid might decrease deaths from gastrointestinal bleeding. We aimed to assess the effects of tranexamic acid in patients with gastrointestinal bleeding. Read More

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http://dx.doi.org/10.1016/S0140-6736(20)30848-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306161PMC

Primary aortogastric fistula: an extraordinary rare endoscopic finding in the setting of upper gastrointestinal bleeding.

Endoscopy 2020 Jun 19. Epub 2020 Jun 19.

Department of Gastroenterology and Digestive Endoscopy, AORN "Antonio Cardarelli", Napoli, Italy.

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http://dx.doi.org/10.1055/a-1180-7701DOI Listing

Validation of a new risk score system for non-variceal upper gastrointestinal bleeding.

BMC Gastroenterol 2020 Jun 17;20(1):193. Epub 2020 Jun 17.

Division of Gastroenterology, Departmentof Internal Medicine, Chungnam National University Hospital, Chungnam National University School of Medicine, 282 Munhwa-ro, Jung-gu, Daejeon, 35015, Republic of Korea.

Background: Recently, a new international bleeding score was developed to predict 30-day hospital mortality in patients with upper gastrointestinal bleeding (UGIB). However, the efficacy of this newly developed scoring system has not been extensively investigated. We aimed to validate a new scoring system for predicting 30-day mortality in patients with non-variceal UGIB and determine whether a higher score is associated with re-bleeding, length of hospital stay, and endoscopic failure. Read More

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http://dx.doi.org/10.1186/s12876-020-01346-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301517PMC

Management of life-threatening aortoesophageal fistula: experiences learned from eight patients.

Acta Radiol 2020 Jun 17:284185120933228. Epub 2020 Jun 17.

Department of Radiology, National Cancer Center, Goyang, Republic of Korea.

Background: Aortoesophageal fistula (AEF) is a rare but fatal condition causing massive upper gastrointestinal bleeding.

Purpose: To report our experiences in the management of life-threatening AEF.

Material And Methods: A total of eight patients (seven men, one woman; mean age = 59. Read More

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http://dx.doi.org/10.1177/0284185120933228DOI Listing

Esophageal Bronchial Artery Fistulaization: A Complication of an Endobronchial Ultrasound.

ACG Case Rep J 2020 Apr 10;7(4):e00355. Epub 2020 Apr 10.

Division of Gastroenterology, University of Florida College of Medicine, Jacksonville, FL.

Bronchial artery pseudoaneurysms are an extremely rare cause of upper gastrointestinal bleeding. The presence of a bronchial artery pseudoaneurysm resulting in an esophageal fistula is an entity that, to our knowledge, has yet to be described. Successful management requires an interdisciplinary approach to guide closure of the defects. Read More

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http://dx.doi.org/10.14309/crj.0000000000000355DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224716PMC

Management of Gastroduodenal Artery Pseudoaneurysm Rupture With Duodenal Ulcer Complicated by Coil Migration.

ACG Case Rep J 2020 Apr 29;7(4):e00347. Epub 2020 Apr 29.

Department of Internal Medicine, Internal Medicine at Northwell Health at Mather Hospital, Port Jefferson, NY.

Rupture of visceral artery aneurysms or visceral artery pseudoaneurysms is an unusual cause of upper gastrointestinal bleeding. Although most visceral artery aneurysms and visceral artery pseudoaneurysms occur in the splenic artery or hepatic artery, they can rarely occur in the gastroduodenal artery. These are at high risk for rupture, with a 40%-70% mortality. Read More

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http://dx.doi.org/10.14309/crj.0000000000000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224706PMC

COVID-19 and gastrointestinal injury: a brief systematic review and data from Bulgaria.

Infez Med 2020 Jun;28(suppl 1):37-41

National Centre of Infectious and Parasitic Diseases, Sofia, Bulgaria.

In December 2019, a new Coronavirus (SARS-CoV-2) emerged in China, causing the pandemic disease COVID-19. The clinical presentation is variable, but the predominant symptoms are those of the upper respiratory tract.

Aim: The aim of the current study is to describe the incidence and type of the gastrointestinal injury (GI) in COVID-19, as well as their prognostic value. Read More

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Portal Hypertension and Chronic Kidney Disease Significantly Increase the Risk of Early Unplanned Readmissions in GAVE- Related Admissions.

J Gastrointestin Liver Dis 2020 Jun 3;29(2):151-157. Epub 2020 Jun 3.

Department of Gastroenterology and Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.

Background And Aims: Gastric antral vascular ectasia (GAVE) is an uncommon cause of non-variceal upper gastrointestinal bleeding that is characterized by dilation of blood vessels in the antrum of the stomach. Various co-morbidities are associated with the development of GAVE, but the impact of co-morbidities on unplanned GAVE readmissions is unclear. The aim of this study was to assess the national incidence, 30-day mortality rate, and 30-day readmissions related to GAVE. Read More

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http://dx.doi.org/10.15403/jgld-804DOI Listing

Empirical assessment of case-based methods for identification of drugs associated with upper gastrointestinal bleeding in the French National Healthcare System database (SNDS).

Pharmacoepidemiol Drug Saf 2020 Jun 10. Epub 2020 Jun 10.

Bordeaux PharmacoEpi, INSERM CIC1401, Université de Bordeaux, Bordeaux, France.

Purpose: Upper gastrointestinal bleeding (UGIB) is a severe and frequent drug-related event. In order to enable efficient drug safety alert generation in the French National Healthcare System database (SNDS), we assessed and calibrated empirically case-based designs to identify drug associated with UGIB risk.

Methods: All cases of UGIB were extracted from SNDS (2009-2014) using two definitions. Read More

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http://dx.doi.org/10.1002/pds.5038DOI Listing

Over-the-Scope Clip to the Rescue! A Novel Tool for Refractory Acute Nonvariceal Upper Gastrointestinal Hemorrhage.

Case Rep Gastroenterol 2020 May-Aug;14(2):261-270. Epub 2020 May 12.

Department of Gastroenterology, Staten Island University Hospital, Northwell Health, Staten Island, New York, USA.

Nonvariceal upper gastrointestinal hemorrhage (NVUGIH) is more prevalent than lower gastrointestinal hemorrhage and carries a high risk of mortality in the elderly, especially those with significant cardiovascular comorbidities. Traditional endoscopic methods, such as through-the-scope clips, electrocautery, and epinephrine injection, are frequently used to control these bleeds; however, they carry a 10% risk of rebleeding, and this itself carries a mortality risk of 36%. The larger over-the-scope clips (OTSC) that were initially used for the closure of fistulas and perforations are now gradually being implemented to manage NVUGIH. Read More

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http://dx.doi.org/10.1159/000507610DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265719PMC

Risk of Hospitalization With Hemorrhage Among Older Adults Taking Clarithromycin vs Azithromycin and Direct Oral Anticoagulants.

JAMA Intern Med 2020 Jun 8. Epub 2020 Jun 8.

Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada.

Importance: Clarithromycin is a commonly prescribed antibiotic associated with higher levels of direct oral anticoagulants (DOACs) in the blood, with the potential to increase the risk of hemorrhage.

Objective: To assess the 30-day risk of a hospital admission with hemorrhage after coprescription of clarithromycin compared with azithromycin among older adults taking a DOAC.

Design, Setting, And Participants: This population-based, retrospective cohort study was conducted among adults of advanced age (mean [SD] age, 77. Read More

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http://dx.doi.org/10.1001/jamainternmed.2020.1835DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281381PMC

A prospective, multicentre study in acute non-cirrhotic, non-malignant portal vein thrombosis: comparison of medical and interventional treatment.

Aliment Pharmacol Ther 2020 Jul 7;52(2):329-339. Epub 2020 Jun 7.

Freiburg, Germany.

Background: To evaluate medical versus interventional treatment (transjugular thrombus fragmentation, local thrombolysis with or without stent implantation) in patients with acute non-cirrhotic, non-malignant portal vein thrombosis (PVT).

Methods: This prospective, observational study enrolled 65 patients with acute (<28 days since begin of symptoms, no cavernoma) PVT in nine centres. Thirty patients received medical treatment and 35 patients received interventional treatment. Read More

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http://dx.doi.org/10.1111/apt.15811DOI Listing

[Two unusual causes of peptic anastomotic ulcer].

Khirurgiia (Mosk) 2020 (5):100-101

Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University), Moscow, Russia.

Two unusual cases of anastomotic ulcer complicated by bleeding after gastric resection are reported. There were retained antrum in one patient and long 'dry' intestinal loop after laparoscopic Roux resection in another one. Emergency gastric stump resection with Haberer procedure were successfully performed in both cases. Read More

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http://dx.doi.org/10.17116/hirurgia2020051100DOI Listing

An Unusual Cause of Lower Gastrointestinal Bleeding: Cecal Dieulafoy's Lesion.

Cureus 2020 May 2;12(5):e7928. Epub 2020 May 2.

Internal Medicine: Gastroenterology, Tufts Medical Center, Boston, USA.

Colonic Dieulafoy's lesions are an exceptionally rare cause of lower gastrointestinal (GI) bleeding. These lesions are almost exclusively found in the upper GI tract based on previous reviews. We present a case of an 81-year-old man who presented with melena progressing to hematochezia and was found to have a cecal Dieulafoy's lesion on colonoscopy. Read More

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http://dx.doi.org/10.7759/cureus.7928DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265779PMC

Liver Cirrhosis Complications Management At The Emergency Department.

Rev Recent Clin Trials 2020 Jun 3. Epub 2020 Jun 3.

Department of Health Sciences, University "Magna Græcia", Catanzaro. Italy.

Background And Aims: liver cirrhosis (LC) of any origin has always been a source of several emergencies for physicians working at the Emergency Department (ER). LC patients can present with several complications that are sometimes difficult to recognize and treat. Thus, we reviewed the literature evidences for the diagnosis and management of several LC related emergencies. Read More

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http://dx.doi.org/10.2174/1574887115666200603160816DOI Listing

Effect of low-dose aspirin on health outcomes: An umbrella review of systematic reviews and meta-analyses.

Br J Clin Pharmacol 2020 Jun 2. Epub 2020 Jun 2.

Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Aims: This study aimed to use an umbrella review methodology to capture the range of outcomes that were associated with low-dose aspirin and to systematically assess the credibility of this evidence.

Methods: Aspirin is associated with several health outcomes, but the overall benefit/risk balance related to aspirin use is unclear. We searched three major databases up to 15 August 2019 for meta-analyses of observational studies and randomized controlled trials (RCTs) including low-dose aspirin compared to placebo or other treatments. Read More

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http://dx.doi.org/10.1111/bcp.14310DOI Listing
June 2020
3.878 Impact Factor

A case of spontaneous mesenteric hematoma with diagnostic difficulty.

Surg Case Rep 2020 Jun 1;6(1):124. Epub 2020 Jun 1.

Department of Surgery, Kochi Medical School Hospital, Kochi University, Kohasu, Oko-cho, Nankoku, Kochi, 783-8505, Japan.

Background: Spontaneous mesenteric hematoma (SMH) is a rare condition characterized by intraperitoneal hemorrhage of unknown etiology. SMH without worsening of general status allows conservative management; however, patients showing chronological changes on imaging require surgical intervention to rule out possible malignancy.

Case Presentation: A 69-year-old man was referred to our hospital to evaluate an abdominal mass with no associated clinical symptoms. Read More

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http://dx.doi.org/10.1186/s40792-020-00867-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266863PMC

Ethnic inequality in non-steroidal anti-inflammatory drug-associated harm in New Zealand: A national population-based cohort study.

Pharmacoepidemiol Drug Saf 2020 May 31. Epub 2020 May 31.

Best Practice Advocacy Centre NZ, Dunedin, New Zealand.

Purpose: Non-steroidal anti-inflammatory drugs (NSAIDs) are associated with many serious complications and they are widely used in New Zealand (NZ). However, differences in NSAID-associated risk for these complications between ethnic groups are largely unknown. We assessed ethnic disparities in risk of hospital admission for upper gastrointestinal bleeding (UGIB), heart failure, and acute kidney failure (AKF) in NZ's primary care population prescribed and dispensed NSAIDs. Read More

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http://dx.doi.org/10.1002/pds.5028DOI Listing

Plasma perfusion combined with plasma exchange in chronic hepatitis B-related acute-on-chronic liver failure patients.

Hepatol Int 2020 May 29. Epub 2020 May 29.

Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, 430030, Hubei Province, China.

Background And Aims: Artificial liver support systems (ALSS) have been shown to significantly reduce mortality in patients with acute-on-chronic liver failure (ACLF). However, the characteristics of patients who would benefit most from ALSS treatment are poorly understood. This study aimed to delineate the indicators for ALSS and evaluate the effectiveness of plasma perfusion combined with plasma exchange (PP + PE) in patients with hepatitis B virus-related ACLF (HBV-ACLF). Read More

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http://dx.doi.org/10.1007/s12072-020-10053-xDOI Listing
May 2020
2.468 Impact Factor

Safety and efficacy of endovascular implantation of a portal vein stent combined with iodine-125 seed-strips followed by transcatheter arterial chemoembolization with sorafenib for the treatment of hepatocellular carcinoma with portal vein tumor thrombosis.

Br J Radiol 2020 Jun 3:20190279. Epub 2020 Jun 3.

Interventional Department, The First Hospital of Lanzhou University, Lanzhou, Gansu, China.

Objective: To assess the safety and efficacy of endovascular implantation of a portal vein stent combined with iodine- seed-strips followed by transcatheter arterial chemoembolization with sorafenib (PVS-I-TACE-S) for the treatment of hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT).

Methods: Between January 2015 and July 2017, 18 patients with PVTT caused by HCC that were treated with PVS-I-TACE-S were reviewed. The technical success, complications, changes in liver function from baseline values due to subsequent endovascular implantation of a portal vein stent combined with iodine- seed-strips (PVS-I), time-to-tumor progression (TTP) and overall survival (OS) were observed. Read More

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http://dx.doi.org/10.1259/bjr.20190279DOI Listing
June 2020
1.533 Impact Factor

Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer related bleeding: multicentre international registry.

Endoscopy 2020 May 26. Epub 2020 May 26.

University College London Hospitals NHS Foundation Trust, Gastroenterology, London, United Kingdom of Great Britain and Northern Ireland.

Introduction Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and associated with a 2-17% mortality in the United Kingdom (UK) and USA [1]. Peptic ulcers account for 50% of UGIB's. Endoscopic intervention in a timely manner can improve outcomes. Read More

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http://dx.doi.org/10.1055/a-1186-5360DOI Listing

Esophageal variceal hemorrhage: the role of MDCT characteristics in predicting the presence of varices and bleeding risk.

Abdom Radiol (NY) 2020 May 23. Epub 2020 May 23.

Department of Radiology, School of Medicine, Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: To investigate the associated Multi-Detector Computed Tomography (MDCT) features for esophageal varices (EVs) and esophageal variceal hemorrhage (EVH), with particular emphasis on different collateral veins.

Materials And Methods: All cirrhotic patients who had undergone both Upper Gastrointestinal Tract (UGIT) endoscopy and contrast-enhanced MDCT within 6 months from 2013 to 2019 were included in the study. MDCT of 124 patients, 76 males and 48 females, aged between 21 and 73 years old were evaluated for presence of EV and presence and size of different collaterals. Read More

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http://dx.doi.org/10.1007/s00261-020-02585-5DOI Listing

Balloon-occluded retrograde transvenous obliteration (BRTO) of gastric varices using foam sclerosant and a reduced balloon inflation time: Feasibility and efficacy.

J Med Imaging Radiat Oncol 2020 May 22. Epub 2020 May 22.

Department of Radiology, Alfred Health, Melbourne, Victoria, Australia.

Introduction: Balloon-occluded retrograde transvenous obliteration (BRTO) is recommended for secondary prevention of gastric variceal bleeding in the American Association for the Study of Liver Disease (AASLD) guidelines, as an alternative to Transjugular intrahepatic portosystemic shunt (TIPS). However, there is significant heterogeneity in how BRTO is performed, including how and how long to occlude the outflow venous shunt amongst other variables such as variceal size, flow rate, agent used, and preparation technique. We propose a method using foam sclerotherapy and reducing balloon occlusion to as little as 30 min, with assessment of the efficacy of this shorter balloon inflation time. Read More

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http://dx.doi.org/10.1111/1754-9485.13049DOI Listing

Readmissions Rates After Myocardial Infarction for Gastrointestinal Bleeding: A National Perspective.

Dig Dis Sci 2020 May 20. Epub 2020 May 20.

Department of Gastroenterology, UMMS-Baystate Medical Center, Springfield, MA, USA.

Background And Aims: Gastrointestinal (GI) bleeding is one most common complications of acute myocardial infarction (AMI). We aimed to determine the incidence, in-hospital outcomes, associated healthcare burden and predictors of GI bleeding within 30 days after AMI.

Methods: Data were extracted from Nationwide Readmission Database 2010-2014. Read More

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http://dx.doi.org/10.1007/s10620-020-06315-1DOI Listing
May 2020
2.550 Impact Factor

Natural history of upper and lower gastrointestinal bleeding in hemodialysis patients: A dual-center long-term cohort study.

J Gastroenterol Hepatol 2020 May 20. Epub 2020 May 20.

Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.

Background And Aim: Knowledge on the risk of gastrointestinal (GI) bleeding in hemodialysis patients is limited. We evaluated the risk of GI bleeding in hemodialysis patients compared with non-hemodialysis patients.

Methods: We performed a retrospective cohort study from 1996 to 2017 at the Graduate School of Medicine, University of Tokyo, and Horinouchi Hospital. Read More

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http://dx.doi.org/10.1111/jgh.15110DOI Listing

Predictors of endoscopic intervention in upper gastrointestinal bleeding patients hospitalized for another illness: a multi-center retrospective study.

Panminerva Med 2020 May 20. Epub 2020 May 20.

Department of Gastroenterology, Galilee Medical Center, Nahariya, Israel.

Background: To characterize variables that may predict the need for endoscopic intervention in inpatients admitted for several causes who during the hospitalization developed acute non-variceal upper gastrointestinal bleeding (NVUGIB).

Methods: A retrospective analysis of inpatients who underwent upper GI endoscopy for acute NVUGIB while hospitalized for other causes from 1st January 2016 till 1st December 2017, was performed. In the primary outcome analysis, patients (n: 14) who underwent endoscopic intervention (group A) were compared to those (n: 87) who did not need for endoscopic intervention (group B). Read More

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http://dx.doi.org/10.23736/S0031-0808.20.03960-9DOI Listing

Coronary artery perforation into the upper gastrointestinal cavity due to gastric ulceration.

Catheter Cardiovasc Interv 2020 May 19. Epub 2020 May 19.

The Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

An 82-year-old man who had previously undergone a proximal gastrectomy with jejunal interposition surgery for stomach cancer was transferred to our hospital for massive hematemesis and hypotension. His electrocardiogram showed ST-segment elevation in lead ΙΙ, ΙΙΙ, aVF, which confirmed inferior myocardial infarction. Due to active hematemesis, upper endoscopy was performed initially. Read More

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http://dx.doi.org/10.1002/ccd.28945DOI Listing

Laparoscopic Heller myotomy and anterior Dor fundoplication for achalasia cardia in Malaysia: Clinical outcomes and satisfaction from four tertiary centers.

Asian J Surg 2020 May 15. Epub 2020 May 15.

Department of General Surgery, Sarawak General Hospital, Kuching, Sarawak, Malaysia.

Background: To evaluate the clinical outcomes and satisfaction of patients following laparoscopic Heller myotomy for achalasia cardia in four tertiary centers.

Methods: Fifty-five patients with achalasia cardia who underwent laparoscopic Heller myotomy between 2010 and 2019 were enrolled. The adverse events and clinical outcomes were analyzed. Read More

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http://dx.doi.org/10.1016/j.asjsur.2020.04.007DOI Listing
May 2020
0.758 Impact Factor

Refractory non-variceal upper gastrointestinal bleeding in a liver-transplant patient: Everolimus withdrawal should be considered.

Therapie 2020 May 8. Epub 2020 May 8.

Service de médecine intensive réanimation & Inserm U1121 & FMTS, faculté de médecine de strasbourg, avenue Molière, hôpitaux universitaires de Strasbourg, 67098 Strasbourg, France; Centre régional de pharmacovigilance, hôpitaux universitaires de Strasbourg, 67091, Strasbourg, France. Electronic address:

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http://dx.doi.org/10.1016/j.therap.2020.04.006DOI Listing