202,848 results match your criteria Upper GI Tract


A review on 5-aminosalicylic acid colon-targeted oral drug delivery systems.

Int J Pharm 2019 Jan 18. Epub 2019 Jan 18.

Targeted Drug Delivery Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutics, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Site-specific colon drug delivery is a practical approach for the treatment of local diseases of the colon with several advantages such as rapid onset of action and reduction of the dosage of the drug as well as minimization of harmful side effects. 5-aminosalicylic acid (5-ASA) is a drug of choice in the treatment of inflammatory bowel disease and colitis. For the efficient delivery of this drug, it is vital to prevent 5-ASA release in the upper part of the gastrointestinal tract and to promote its release in the proximal colon. Read More

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http://dx.doi.org/10.1016/j.ijpharm.2019.01.022DOI Listing
January 2019

Cortrak duodenal tube placements: A solution for more patients? A preliminary survey to the introduction of electromagnetic-guided placement of naso-duodenal feeding tubes.

Clin Nutr ESPEN 2019 Feb 1;29:133-136. Epub 2018 Dec 1.

Department of Nutrition and Dietetics, Amsterdam UMC/Vrije Universiteit, Amsterdam, the Netherlands; Department of Nutrition and Health, HAN University of Applied Sciences, Nijmegen, the Netherlands.

Rationale: The Cortrak feeding tube, an electromagnetic (EM) guided feeding tube which is placed by a trained nurse at the patient's bedside, is reported to be a safe, patient friendly and cost effective answer to the disadvantages of endoscopic placement of naso-duodenal feeding tubes. However, this procedure requires a learning curve and regular practice. This study aims to evaluate whether introducing Cortrak® feeding tube placement would be profitable in a tertiary referral academic hospital. Read More

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http://dx.doi.org/10.1016/j.clnesp.2018.11.006DOI Listing
February 2019

Safety assessment of L-lysine oral intake: a systematic review.

Amino Acids 2019 Jan 19. Epub 2019 Jan 19.

Laboratory of Food Chemistry, Yokohama University of Pharmacy, 601 Matano-cho, Totsuka-ku, Yokohama, Kanagawa, 245-0066, Japan.

Currently, the use of amino acids in supplements and functional foods is increasing globally. However, there are no guidelines for the upper limit of ingestion for the safe use of these amino acids. Safety evaluation of chemical substances is generally performed through non-clinical and clinical studies. Read More

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http://dx.doi.org/10.1007/s00726-019-02697-3DOI Listing
January 2019

Symptomatic involvement of the stomach and duodenum as initial presentation of AL amyloidosis.

BMJ Case Rep 2019 Jan 17;12(1). Epub 2019 Jan 17.

Cleveland Clinic Florida, Weston, Florida, USA.

Primary systemic or amyloid light chain (AL) amyloidosis is a multisystem disorder with myriad presentations. Although it can involve the upper gastrointestinal tract in 8% of cases, symptomatic involvement is exceedingly rare. We chronicle here a case of postprandial epigastric pain associated with AL amyloidosis involving the stomach and duodenum. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22755
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http://dx.doi.org/10.1136/bcr-2018-227550DOI Listing
January 2019
1 Read

Menopausal hormone therapy and biliary tract cancer: a population-based matched cohort study in Sweden.

Acta Oncol 2019 Jan 18:1-6. Epub 2019 Jan 18.

f Centre for Translational Microbiome Research, Department of Microbiology , Tumor and Cell biology, Karolinska Institutet, Karolinska Hospital , Stockholm , Sweden.

Background: This study tested the hypothesis that contemporary menopausal hormonal therapy (MHT) increases the risk of biliary tract cancer. The risk of cancer of the biliary tract (gallbladder and extra-hepatic bile ducts) may be increased following estrogen exposure.

Material And Methods: This was a nationwide population-based matched cohort study in Sweden. Read More

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https://www.tandfonline.com/doi/full/10.1080/0284186X.2018.1
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http://dx.doi.org/10.1080/0284186X.2018.1549367DOI Listing
January 2019
1 Read

Can Iodixanol Prevent Post-Endoscopic Retrograde Cholangiopancreatography Pancreatitis? A Prospective, Randomized, Controlled Trial.

Dig Dis 2019 Jan 17:1-7. Epub 2019 Jan 17.

Background: It is yet not clear whether differences in the contrast medium may affect post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP).

Aim: The aim of this study was to evaluate the rate of PEP between high osmolality contrast medium (HOCM) and iso osmolar medium (IOCM) in a prospective, randomized, controlled trial.

Methods: Patients who were scheduled to undergo a diagnostic or therapeutic procedure under ERCP guidance were included. Read More

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https://www.karger.com/Article/FullText/496349
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http://dx.doi.org/10.1159/000496349DOI Listing
January 2019
1 Read

State of clinical research of radiotherapy/chemoradiotherapy and immune checkpoint inhibitor therapy combinations in solid tumours-a German radiation oncology survey.

Eur J Cancer 2019 Jan 12;108:50-54. Epub 2019 Jan 12.

Department of Radiation Oncology, University Hospital, LMU Munich, Munich, Germany; Comprehensive Pneumology Center Munich (CPM-M), Member of the German Center for Lung Research (DZL), Germany.

Combinations of immune checkpoint inhibitors (ICIs) with radiotherapy and/or chemoradiotherapy are currently under investigation in many cancer types and clinical settings. In this survey, we solicited members of the German Radiation Oncology Society and young DEGRO (working group of DEGRO e.V. Read More

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http://dx.doi.org/10.1016/j.ejca.2018.11.026DOI Listing
January 2019

Gastrostomy placement : when fluoroscopy helps the endoscopist.

Acta Gastroenterol Belg 2018 Oct-Dec;81(4):525-527

CHU Brugmann, Hepato Gastroenterology, Brussels, Belgium.

Background And Study Aims: Percutaneous endoscopic gastrostomy is the most common therapeutic procedure performed by the digestive endoscopists in the upper gastrointestinal tract. It aims to feed patients presenting denutrition and/or insufficient oral intake. Percutaneous endoscopic gastrostomy feasibility is about 95-100 % although in some cases it is impossible to achieve it, leading to ask for a surgical placement. Read More

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January 2019

Should we worry about incidental gastrointestinal tract involvement in positron emission tomography/computed tomography as gastroenterologist?

Acta Gastroenterol Belg 2018 Oct-Dec;81(4):471-475

Istanbul University, Istanbul Medical Faculty, Department of Gastroenterology.

Background And Aim: Positron emission tomography/computed tomography(PET/CT) scans detects benign clinical conditions in addition to malignancy, and this leads to additional investigation and expenditure. The purpose of our study was to assess the endoscopic and histopathologic results of incidental 18F-FDG uptake in the GI tract.

Patients And Method: We enrolled 110 patients who underwent gastroscopy/colonoscopy for incidental GI tract involvement in PET/CT. Read More

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January 2019

A UGT1A1 genotype-guided dosing study of modified FOLFIRINOX in previously untreated patients with advanced gastrointestinal malignancies.

Cancer 2019 Jan 15. Epub 2019 Jan 15.

Section of Hematology/Oncology, University of Chicago, Chicago, Illinois.

Background: FOLFIRINOX (5-fluorouracil [5-FU], leucovorin, irinotecan, oxaliplatin) is an effective but toxic therapy for pancreatic cancer. UGT1A1 (UDP glucuronosyltransferase 1A1) eliminates the active metabolite of irinotecan. Polymorphisms reduce UGT1A1 activity, leading to toxicity. Read More

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http://doi.wiley.com/10.1002/cncr.31938
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http://dx.doi.org/10.1002/cncr.31938DOI Listing
January 2019
4 Reads

The role of infections in multiple sclerosis.

Mult Scler 2019 Jan 14:1352458518823940. Epub 2019 Jan 14.

Department of Neurology, FLENI, Buenos Aires, Argentina; Center for Research on Neuroimmunological Diseases, FLENI, Buenos Aires, Argentina.

Several lines of evidence suggest that multiple sclerosis (MS), like other autoimmune diseases, may be triggered by microbial infections. Pathogens associated with development or exacerbation of MS include bacteria, such as Chlamydia pneumoniae, Staphylococcus aureus-produced enterotoxins that function as superantigens, and viruses of the Herpesviridae (Epstein-Barr virus and human herpes virus 6) and human endogenous retrovirus families. However, to date, no single pathogen has been accepted as causal agent. Read More

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http://dx.doi.org/10.1177/1352458518823940DOI Listing
January 2019
1 Read

Diagnostic utility of nasogastric tube aspiration and the ratio of blood urea nitrogen to creatinine for distinguishing upper and lower gastrointestinal tract bleeding.

Emergencias 2018 Dic;30(6):419-423

Servicio de Aparato Digestivo, Hospital Universitari ParcTaulí. Institut d'Investigació i Innovació ParcTaulí, Barcelona, España. Departamento de Medicina. Universitat Autònoma de Barcelona, España.

Objectives: The American College of Gastroenterology's 2016 clinical guidelines for treating lower gastrointestinal (GI) tract bleeding recommends evaluating of nasogastric tube aspiration and the ratio of blood urea nitrogen (BUN) to creatinine to differentiate upper from lower GI bleeds. However, the evidence base to support recommending these 2 diagnostic variables is low. This study aimed to evaluate the diagnostic utility of nasogastric tube aspiration and the BUN-to-creatinine ratio for distinguishing between upper and lower GI bleeding. Read More

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January 2019
1 Read

Low-moisture food matrices as probiotic carriers.

FEMS Microbiol Lett 2019 Jan 9. Epub 2019 Jan 9.

Department of Food Science, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.

To exert a beneficial effect on the host, adequate doses of probiotics must be administered and maintaining their viability until consumption is thus essential. Dehydrated probiotics exhibit enhanced long-term viability and can be incorporated into low-moisture food matrices which also possess high stability at refrigeration and ambient temperature. However, several factors associated with the desiccation process, the physicochemical properties of the matrix and the storage conditions can affect probiotic survival. Read More

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http://dx.doi.org/10.1093/femsle/fnz006DOI Listing
January 2019

A lipolysis-permeation setup for simultaneous study of digestion and absorption in vitro.

Mol Pharm 2019 Jan 10. Epub 2019 Jan 10.

Lipid-based formulations (LBFs) are a delivery strategy to enhance intestinal absorption of poorly water-soluble drugs. LBF performance is typically evaluated by in vitro lipolysis studies, but these do not accurately predict the in vivo performance. One possible reason is the absence of an absorptive membrane driving sink conditions in the serosal compartment. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b00811DOI Listing
January 2019
1 Read

Aryl hydrocarbon receptor activation modulates γδ intestinal intraepithelial lymphocytes and protects against ischemia/reperfusion injury in the murine small intestine.

Mol Med Rep 2019 Jan 4. Epub 2019 Jan 4.

Department of General Surgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, P.R. China.

The pathogenesis of intestinal ischemia/reperfusion (I/R) is associated with dysregulation of the intestinal immune system. The aryl hydrocarbon receptor (AhR), a receptor expressed in gamma‑delta (γδ) intraepithelial lymphocytes (IELs), is thought to regulate inflammation in the bowel. γδIELs are a key immunologic compartment with a capacity to modulate immune responses. Read More

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http://www.spandidos-publications.com/10.3892/mmr.2019.9823
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http://dx.doi.org/10.3892/mmr.2019.9823DOI Listing
January 2019
1 Read

"Trachealization" of the Esophagus.

N Engl J Med 2019 Jan;380(2):177

University of New Mexico, Albuquerque, NM

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http://dx.doi.org/10.1056/NEJMicm1807124DOI Listing
January 2019
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Proteomic Evaluation of the Acute Radiation Syndrome of the Gastrointestinal Tract in a Murine Total-body Irradiation Model.

Health Phys 2019 Jan 7. Epub 2019 Jan 7.

University of Maryland, School of Pharmacy, Department of Pharmaceutical Sciences, Baltimore, MD.

Radiation exposure to the gastrointestinal system contributes to the acute radiation syndrome in a dose- and time-dependent manner. Molecular mechanisms that lead to the gastrointestinal acute radiation syndrome remain incompletely understood. Using a murine model of total-body irradiation, C57BL/6J male mice were irradiated at 8, 10, 12, and 14 Gy and assayed at day 1, 3, and 6 after exposure and compared to nonirradiated (sham) controls. Read More

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http://dx.doi.org/10.1097/HP.0000000000000951DOI Listing
January 2019
1 Read
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HER2/neu (ERBB2) expression and gene amplification correlates with better survival in esophageal adenocarcinoma.

BMC Cancer 2019 Jan 8;19(1):38. Epub 2019 Jan 8.

Department of General, Visceral and Cancer Surgery, University Hospital Cologne, Cologne, Germany.

Background: HER2 (ERBB2 or HER2/neu) is a tyrosine-kinase increasing cell proliferation. Overexpression/amplification of HER2 is correlated with worse prognosis in solid malignancies. Consequently, HER2 targeting is established in breast and upper gastrointestinal tract cancer. Read More

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http://dx.doi.org/10.1186/s12885-018-5242-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325716PMC
January 2019
1 Read

Postoperative Complication Assessments of Different Reconstruction Procedures after Total Pharyngolaryngoesophagectomy: Tubular Gastric Pull-Up Whole Gastric Pull-Up.

Am Surg 2018 Dec;84(12):1927-1931

Hypopharynx carcinoma tends to be diagnosed at advanced stage and usually has a poor prognosis because of the high incidence of submucosal spreading and lymphatic metastasis. Total pharyngolaryngoesophagectomy (PLE) is mostly used as a curative intervention for this deadly disease, and a commonly used reconstruction method after PLE is gastric pull-up, which could be further divided into tubular gastric pull-up and whole gastric pull-up procedures. Aiming to achieve a precise guidance on optimal reconstruction method after PLE, the present study evaluated the postoperative complications involving in different gastric pull-up procedures in patients with hypopharynx cancer. Read More

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December 2018
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Relationship between the Body Mass Index and Tumor Site Postoperative Complications and Prognosis in Gastric Adenocarcinoma.

Am Surg 2018 Dec;84(12):1861-1868

The impact of BMI on survival in gastric cancer (GC) is not clear. We sought to explore the relationship between BMI and tumor site, clinicopathologic characteristics, postoperative complications, and prognosis in GC patients. Patients who underwent gastrectomy for GC between January 2011 and June 2016 formed the study cohort (n = 827). Read More

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December 2018
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Comparison of body condition score and other minimally invasive biomarkers between dogs with gastric carcinoma and dogs with chronic gastritis.

J Am Vet Med Assoc 2019 Jan;254(2):226-235

OBJECTIVE To identify minimally invasive biomarkers to help differentiate dogs with gastric carcinoma from those with chronic gastritis. DESIGN Prospective study. ANIMALS 15 dogs with gastric carcinoma, 29 dogs with chronic gastritis, and 7 healthy dogs. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.254.2.226
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http://dx.doi.org/10.2460/javma.254.2.226DOI Listing
January 2019
7 Reads

Per oral endoscopic tumor (POET) resection for treatment of upper gastrointestinal subepithelial tumors.

Surg Endosc 2019 Jan 2. Epub 2019 Jan 2.

Division of Upper GI and Metabolic Surgery, Department of Surgery and State Key Laboratory of Digestive Diseases, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong S.A.R., The People's Republic of China.

Background: Endoscopic submucosal tunneling has evolved to allow endoscopic resection of subepithelial tumors of gastrointestinal tract without full-thickness perforation. This study aimed to investigate safety and efficacy of submucosal tunnel resection for these tumors.

Method: Patients with subepithelial tumors (SET) located in esophagus, gastric cardia, lesser curvature, and antrum were recruited. Read More

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http://link.springer.com/10.1007/s00464-018-06627-4
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http://dx.doi.org/10.1007/s00464-018-06627-4DOI Listing
January 2019
3 Reads

Behaviour of citrus pectin during its gastrointestinal digestion and fermentation in a dynamic simulator (simgi®).

Carbohydr Polym 2019 Mar 28;207:382-390. Epub 2018 Nov 28.

Instituto de Investigación en Ciencias de la Alimentación, CIAL (CSIC-UAM), C/ Nicolás Cabrera, 9, Campus de la Universidad Autónoma de Madrid, 28049, Madrid, Spain. Electronic address:

The behaviour of citrus pectin during digestion and its potential prebiotic properties were examined using a Dynamic Gastrointestinal Simulator (simgi®) model for the human gut, which simulates processes in the stomach, small intestine, ascending, transverse and descending colon. A remarkable non-digestibility of pectin in the upper gastrointestinal tract was observed by HPLC-ELSD analysis, where ∼88% of citrus pectin remained intact during its transit through the stomach and small intestine. Fermentation of pectin stimulated the growth of beneficial bacteria such as Bifidobacterium spp, Bacteroides spp and Faecalobacterium prausnitzii. Read More

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http://dx.doi.org/10.1016/j.carbpol.2018.11.088DOI Listing

[Special case of purulent meningitis caused by Streptococcus suis. Case report].

Orv Hetil 2019 Jan;160(1):30-34

Gyermekorvosi Alapellátás Győr.

The authors describe the case of purulent meningitis of a male patient who has been diagnosed with the role of Streptococcus suis in the background of the infection. The bacterium is a colonizing agent in the upper respiratory, gastrointestinal tract, and genital organs of various animals (pigs, ruminants, cats, dogs, deer and horses). The pathogen is predominantly animal pathogenic, but human cases also occur with zoonotic origin. Read More

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https://www.akademiai.com/doi/10.1556/650.2019.31243
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http://dx.doi.org/10.1556/650.2019.31243DOI Listing
January 2019
2 Reads

Investigation onto the correlation between systemic antibodies to surface glycoproteins of infectious laryngotracheitis virus (ILTV) and protective immunity.

Vet Microbiol 2019 Jan 11;228:252-258. Epub 2018 Dec 11.

Asia Pacific Centre for Animal Health, The University of Melbourne, Werribee, VIC, 3030, Australia.

Infectious laryngotracheitis virus (ILTV) is an alphaherpesvirus that causes upper respiratory tract disease in chickens and significant losses to the poultry industry worldwide. Both antibody and cell-mediated responses are generated against ILTV infection; however, the correlation of humoral immune response with protection against ILTV infection is debatable. To examine if whether antibody responses to individual ILTV glycoproteins are correlated with disease and protection, four ILTV glycoproteins (gD, gE, gG and gJ) were expressed as recombinant proteins and used in conjunction with commercially available recombinant gC and gI in indirect ELISAs to measure post-vaccination and/or post-challenge chicken serum antibodies. Read More

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http://dx.doi.org/10.1016/j.vetmic.2018.12.010DOI Listing
January 2019

Prospective evaluation of clinical outcomes and quality of life after gastric tube interposition as esophageal reconstruction in children.

Medicine (Baltimore) 2018 Dec;97(52):e13801

Department of Pediatric Surgery, Seoul National University College of Medicine, Seoul, Korea.

Few studies on gastric tube interposition for esophageal reconstruction in children have assessed the long-term outcomes and quality of life (QoL). The aim of this study is to evaluate the long-term outcomes and QoL after a gastric tube interposition by reviewing our experiences with esophageal reconstruction.Twenty-six patients were included who underwent gastric tube interposition from 1996 to 2011 at our institution. Read More

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http://dx.doi.org/10.1097/MD.0000000000013801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314723PMC
December 2018
2 Reads

Predictors of Acute Radiation Esophagitis in Non-small Cell Lung Cancer Patients Treated With Accelerated Hyperfractionated Chemoradiotherapy.

Anticancer Res 2019 Jan;39(1):491-497

Department of Radiation Oncology, Osaka International Cancer Institute Hospital, Osaka, Japan.

Background/aim: To identify the clinical and dosimetric predictors of severe acute radiation esophagitis (RE) in patients with non-small cell lung cancer (NSCLC) treated with accelerated hyperfractionated concurrent chemoradiotherapy (AH-CCRT) with concomitant boost technique.

Patients And Methods: A total of 159 patients who underwent AH-CCRT (64 Gy in 40 fractions twice daily) were retrospectively identified. Severe RE was designated as grade 3 or higher according to the Common Terminology Criteria for Adverse Events, version 4. Read More

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http://dx.doi.org/10.21873/anticanres.13139DOI Listing
January 2019

Lower Esophageal Sphincter-preserving Anastomosis Is an Acceptable Reconstruction Method Following Laparoscopy-assisted Proximal Gastrectomy.

Anticancer Res 2019 Jan;39(1):425-430

Department of Surgery; Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea

Background/aims: Our study aimed to compared 3-year results following laparoscopy-assisted proximal gastrectomy (LAPG)-double tract anastomosis (DTA) and lower esophageal sphincter-preserving LAPG (LES-LAPG).

Patients And Methods: Nine patients who underwent LES-LAPG and 23 LAPG-DTA were compared regarding 3-year follow-up complications, the anemia-related parameter and albumin levels.

Results: During the 3-year follow-up period, no patient (0%) in the LES-LAPG and six patients (6/23, 26. Read More

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http://dx.doi.org/10.21873/anticanres.13129DOI Listing
January 2019
1 Read

Probiotics and sports: a new magic bullet?

Nutrition 2018 Oct 22;60:152-160. Epub 2018 Oct 22.

Laboratory of Nutrition and Metabolism Applied to Motor Activity, School of Physical Education and Sports, University of Sao Paulo, Sao Paulo, Brazil.

The use of probiotics in sports has been growing in the past years focusing on the attenuation of upper respiratory tract (URS) and gastrointestinal (GI) symptoms commonly present in endurance athletes. Researches shown different results and this may related to the probiotic strain, dose, period consumption or even the form of administration (capsules, sachets or fermented milk). These four factors directly influence in the probiotic's outcome and this question still remains unclear. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08999007183065
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http://dx.doi.org/10.1016/j.nut.2018.09.023DOI Listing
October 2018
5 Reads

Idarucizumab for Dabigatran Reversal in the Management of Patients with Major Gastrointestinal Bleeding.

Circulation 2018 Oct 29. Epub 2018 Oct 29.

Thrombosis and Hemostasis, Leiden University Medical Center Leiden, NETHERLANDS.

Background: Although dabigatran has a favourable risk-benefit profile compared to vitamin K antagonist therapy for venous thromboembolism and non-valvular atrial fibrillation, major bleeding events - including gastrointestinal (GI) bleeding - may occur. Therefore, our aim was to provide insights on the efficacy and safety of idarucizumab for urgent dabigatran reversal in patients with major GI bleeding.

Methods: Patients with uncontrollable GI bleeding were enrolled from June 2014 through July 2016 in RE-VERSE AD, a prospective, multi-centre, open-label study of idarucizumab and were followed for 90 days for primary and secondary outcomes. Read More

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http://dx.doi.org/10.1161/CIRCULATIONAHA.118.036710DOI Listing
October 2018
1 Read

Experiences with fecal microbiota transplantation in Clostridium difficile infections via upper gastrointestinal tract.

Acta Microbiol Immunol Hung 2018 Dec 26:1-10. Epub 2018 Dec 26.

1 Department of Infectology, 1st Department of Internal Medicine, University of Pécs , Pécs, Hungary.

Dramatic changes in the epidemiology of Clostridium difficile infections have been reported from the western world in the past decade. The proportion of severe cases is significantly elevating and clinicians now have to contend with the problem of additional and more frequent episodes of recurrences including an upward trend in the mortality rate. This situation led us to investigate the possibility of the fecal microbiota transplantation (FMT). Read More

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http://dx.doi.org/10.1556/030.65.2018.051DOI Listing
December 2018
1 Read

Enzymatically cross-linked arabinoxylan microspheres as oral insulin delivery system.

Int J Biol Macromol 2018 Dec 22;126:952-959. Epub 2018 Dec 22.

University of Sonora, Rosales y Blvd. Luis D. Colosio, Hermosillo, Sonora 83000, Mexico. Electronic address:

Arabinoxylans (AX) microspheres with different insulin/AX mass ratio were prepared by formation of phenoxy radical issued from the ferulic acid by enzymatic oxidation (entrapped in situ of insulin). Phenolic acid content and FT-IR spectrum of unloaded and insulin-loaded AX microspheres revealed that the phenoxy radical issued from the ferulic acid by enzymatic oxidation did not interact covalently with insulin. The microspheres showed a spherical shape, smooth surface and an average diameter of particles of 320 μm. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2018.12.192DOI Listing
December 2018

Secondary extramedullary plasmacytoma of sigmoid colon in a patient with multiple myeloma: a case report.

J Med Case Rep 2018 Dec 25;12(1):379. Epub 2018 Dec 25.

Computed Tomography Department, Konstantpouleio General Hospital Nea Ionia, Athens, Greece.

Background: Extramedullary plasmacytoma is an uncommon tumor that most often involves the nasopharynx or upper respiratory tract. Extramedullary plasmacytoma is a type of plasma cell neoplasm that can present as a primary tumor or secondary to another plasma cell neoplasm, such as multiple myeloma. Secondary extramedullary plasmacytoma is usually noted in the advanced stages of the disease. Read More

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http://dx.doi.org/10.1186/s13256-018-1888-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6305571PMC
December 2018
1 Read

Nondigestible carbohydrates, butyrate, and butyrate-producing bacteria.

Crit Rev Food Sci Nutr 2018 Dec 22:1-23. Epub 2018 Dec 22.

a College of Food Science and Engineering , Ocean University of China , Qingdao , China.

Nondigestible carbohydrates (NDCs) are fermentation substrates in the colon after escaping digestion in the upper gastrointestinal tract. Among NDCs, resistant starch is not hydrolyzed by pancreatic amylases but can be degraded by enzymes produced by large intestinal bacteria, including clostridia, bacteroides, and bifidobacteria. Nonstarch polysaccharides, such as pectin, guar gum, alginate, arabinoxylan, and inulin fructans, and nondigestible oligosaccharides and their derivatives, can also be fermented by beneficial bacteria in the large intestine. Read More

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http://dx.doi.org/10.1080/10408398.2018.1542587DOI Listing
December 2018

Robotic total gastrectomy with π-shaped esophagojejunostomy using a linear stapler as a novel technique.

World J Surg Oncol 2018 Dec 21;16(1):238. Epub 2018 Dec 21.

Department of Gastrointestinal Surgery, Department of General Surgery, First Affiliated Hospital of Anhui Medical University, 218 JiXi Avenue, Hefei, 230022, Anhui, China.

Objective: To evaluate the intraoperative and short-term postoperative outcomes of a novel robotic intracorporeal π-shaped esophagojejunostomy (EJS) after D2 total gastrectomy (TG) using the Da Vinci robotic surgical system for intracorporeal anastomosis after TG.

Background: Intracorporeal π-shaped EJS, using a linear stapler, was recently reported for laparoscopic total gastrectomy in patients with gastric cancer. However, robotic intracorporeal π-shaped EJS using a linear stapler has not been reported. Read More

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http://dx.doi.org/10.1186/s12957-018-1542-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303991PMC
December 2018
1 Read

Primary gastrointestinal amyloidosis with gastrointestinal hemorrhage and intestinal pseudo-obstruction: a report of a rare case.

Clin J Gastroenterol 2018 Dec 20. Epub 2018 Dec 20.

Division of Gastroenterology, St. Luke's International Hospital, 9-1 Akashi-cho chuo-ku, Tokyo, 104-8340, Japan.

Amyloidosis is a syndrome involving amyloid protein deposition in various organs, resulting in organ dysfunction. Symptoms of gastrointestinal amyloidosis are usually nonspecific, such as diarrhea and body weight loss. We, here, report a patient who presented to the hospital with simultaneous hematemesis, melena, and intestinal pseudo-obstruction, leading to a diagnosis of primary gastrointestinal amyloidosis based on computed tomography (CT) and endoscopic findings. Read More

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http://dx.doi.org/10.1007/s12328-018-00929-9DOI Listing
December 2018
1 Read

Gastric Metastasis Mimicking Linitis Plastica 20 Years after Primary Breast Cancer. A Case Report.

J Gastrointestin Liver Dis 2018 Dec;27(4):469-471

Department of Medical Oncology, Pôle de Santé Saint Jean, Cagnes-sur-Mer, France.

Breast cancer metastases to the gastrointestinal tract are rare, with a median time interval from the diagnosis of the primary tumor to metastasis up to 7 years. The stomach is the most frequent metastatic site and invasive lobular carcinoma is the type with the highest affinity to the digestive system. We report the case of an 84-year-old female patient, with a past medical history 20 years earlier of invasive lobular carcinoma of the breast, who presented for dyspepsia. Read More

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http://dx.doi.org/10.15403/jgld.2014.1121.274.gasDOI Listing
December 2018

Endoscopic submucosal dissection of early gastric cancer with mixed-type histology: Protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2018 Dec;97(51):e13838

Department of Internal Medicine.

Background: Endoscopic submucosal dissection (ESD) is a primary treatment for the early gastric cancer (EGC) who have a negligible risk of lymph node metastasis satisfying specific criteria. These criteria are histologically categorized by EGC with differentiated-type histology (EGC-DH) and undifferentiated-type histology (EGC-UH). However, gastric cancer is histologically heterogenous and there has been no specific criteria for EGC with mixed-type histology (EGC-MH). Read More

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http://dx.doi.org/10.1097/MD.0000000000013838DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320129PMC
December 2018
5.723 Impact Factor

Endoscopic titanium clip closure of gastric fistula after splenectomy: A case report.

World J Clin Cases 2018 Dec;6(15):1047-1052

Department of Gastrointestinal Surgery, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

This report describes a 52-year-old male patient with blunt abdominal traumatic rupture of the spleen due to injuries sustained in an automobile accident. Following splenectomy, the patient developed a gastric fistula. He underwent a long period of conservative treatment, including antibiotics and total parenteral nutrition, which was ineffective. Read More

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http://www.wjgnet.com/2307-8960/full/v6/i15/1047.htm
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http://dx.doi.org/10.12998/wjcc.v6.i15.1047DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288501PMC
December 2018
5 Reads

Clinicopathological parameters predicting recurrence of pT1N0 esophageal squamous cell carcinoma.

World J Gastroenterol 2018 Dec;24(45):5154-5166

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

Aim: To identify the clinicopathological characteristics of pT1N0 esophageal squamous cell carcinoma (ESCC) that are associated with tumor recurrence.

Methods: We reviewed 216 pT1N0 thoracic ESCC cases who underwent esophagectomy and thoracoabdominal two-field lymphadenectomy without preoperative chemoradiotherapy. After excluding those cases with clinical follow-up recorded fewer than 3 mo and those who died within 3 mo of surgery, we included 199 cases in the current analysis. Read More

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http://www.wjgnet.com/1007-9327/full/v24/i45/5154.htm
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http://dx.doi.org/10.3748/wjg.v24.i45.5154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288646PMC
December 2018
4 Reads

Incidental giant obstructed pedunculated gastric lipoma during gastrostomy: A case report.

Int J Surg Case Rep 2018 24;53:433-435. Epub 2018 Nov 24.

General Surgery Department, Al-Mouwasat University Hospital, Mazzeh, Omar ben Abdulaziz St., Damascus, Syria; Department of Surgery, Syrian Private University, Faculty of Medicine, Damascus, Syria. Electronic address:

Background: Most gastric lipomas are small, asymptomatic, and detected as incidental findings on radiologic evaluation or endoscopic examination of the upper gastrointestinal tract. We report a large lipoma which was noticed by its mass effect during a percutaneous endoscopic gastrostomy; the full evaluation prevented an unexplained failed procedure.

Presentation: A 65 year old man with a cerebrovascular accident (CVA) suffered from resistant vomiting and severe dysphagia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183056
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http://dx.doi.org/10.1016/j.ijscr.2018.11.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262802PMC
November 2018
6 Reads

Complicated duodenal-jejunal diverticulosis: case report.

G Chir 2018 Nov-Dec;39(6):395-398

Background: Bleedings such as melaena are related to diseases in the upper gastrointestinal tract. In 0.06% - 5% of cases these incidents are due to the presence of diverticula of the small intestine, which are asymptomatic and unrecognized in most patients and are only fully diagnosed in cases when complications occur. Read More

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December 2018
1 Read

A non-invasive method for the diagnosis of upper GI diseases.

Acta Biomed 2018 Dec 17;89(8-S):40-43. Epub 2018 Dec 17.

Department of Medicine and Surgery, University of Parma, Parma, Italy.

Upper-GI diseases are one of the most relevant issue in primary care. Nowadays they are still responsible for about 100 million ambulatory care visits only in the US. The diagnosis of almost every upper-GI condition is still deputed to invasive tests such as upper gastrointestinal endoscopy, gastroesophageal manometry or radiography. Read More

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http://dx.doi.org/10.23750/abm.v89i8-S.7917DOI Listing
December 2018
3 Reads

Optimal processing of ESD specimens to avoid pathological artifacts.

Tech Coloproctol 2018 11 17;22(11):857-866. Epub 2018 Dec 17.

Institute of Pathology Spedali Civili, Brescia, Italy.

Background: En bloc endoscopic submucosal dissection (ESD) has been recently introduced as a treatment for precancerous/neoplastic gastrointestinal conditions. The aim of the present study was histological assessment of en bloc ESD specimens.

Methods: Fifty-three ESD specimens were positioned over a cellulose acetate support (40 specimens; 12 from the upper gastrointestinal tract and 28 from the lower gastrointestinal tract) or pinned with nails on polystyrene or cork (13 specimens; 7 from the upper gastrointestinal tract and 6 from the lower gastrointestinal tract). Read More

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http://dx.doi.org/10.1007/s10151-018-1887-xDOI Listing
November 2018

A huge gastric bezoar treated by traditional Chinese medicine purgative: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13712

Department of Gastroenterology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China.

Rationale: Currently, the mainstream treatment for gastric bezoars is endoscopic lithotripsy. This report describes traditional Chinese medicine (TCM) purgative cured a 62-year-old woman with a huge gastric bezoar accompanied by isolated esophageal venous aneurysms and multiple bleeding gastric ulcers.

Patient Concerns: A 62-year-old woman with several symptoms, including epigastric pain, nausea, and vomiting, hiccups, heartburn, and dark, loose stools. Read More

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http://Insights.ovid.com/crossref?an=00005792-201812140-0012
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http://dx.doi.org/10.1097/MD.0000000000013712DOI Listing
December 2018
8 Reads

Efficacy and safety of laparoscopic splenectomy and esophagogastric devascularization for portal hypertension: A single-center experience.

Medicine (Baltimore) 2018 Dec;97(50):e13703

Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital Affiliated to Shandong University.

Many patients in China have portal hypertension secondary to liver cirrhosis. Splenectomy and devascularization have become an efficacious surgical procedure for portal hypertension, and has been recommended in China as the first choice for the treatment of portal hypertension for a long time. As a result of advances in laparoscopic equipment and techniques, splenectomy and esophagogastric devascularization have been carried out with laparoscope. Read More

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http://dx.doi.org/10.1097/MD.0000000000013703DOI Listing
December 2018
1 Read
5.723 Impact Factor

Endoscopic ultrasound-guided internalization of a pancreaticocutaneous fistula utilizing a balloon-target technique: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13564

Rationale: Endoscopic ultrasound (EUS)-guided treatment has been recently described for internalizing refractory pancreaticocutaneous fistulas (PCFs). However, the existing techniques are limited because of the difficulty in accessing nondilated pancreatic ducts or fistulas. In an attempt to overcome this limitation, we present a case where a EUS-guided intervention utilizing a balloon-target technique was employed to internalize a PCF into the stomach. Read More

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http://dx.doi.org/10.1097/MD.0000000000013564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320205PMC
December 2018
1 Read

Common Bacterial and Viral Infections: Review of Management in the Pregnant Patient.

Ann Pharmacother 2018 Dec 17:1060028018817935. Epub 2018 Dec 17.

1 University of South Carolina College of Pharmacy, Columbia, SC, USA.

Objective: To review the treatment of common bacterial and viral infections occurring in the pregnant patient.

Data Sources: A literature search of MEDLINE was performed (inception to October 2018). The Centers for Disease Control and Prevention website was utilized for additional information. Read More

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http://dx.doi.org/10.1177/1060028018817935DOI Listing
December 2018
6 Reads

Comparison of 2 differently sized endoscopic biopsy forceps in the evaluation of intestinal disease in cats.

J Vet Intern Med 2018 Dec 17. Epub 2018 Dec 17.

Dipartimento di Medicina Veterinaria, University of Perugia, Perugia, Italy.

Background: In clinical practice, histopathological diagnosis of chronic intestinal disease is challenging because of difficulty in obtaining adequate duodenal samples. At present, no studies have investigated the influence of biopsy forceps size on sample quality in cats.

Objectives: Duodenal biopsy using larger biopsy forceps (2. Read More

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http://dx.doi.org/10.1111/jvim.15356DOI Listing
December 2018

A case of completely isolated advanced enteric duplication cyst cancer performed partial pancreatectomy.

Int J Surg Case Rep 2018 Nov 27;54:83-86. Epub 2018 Nov 27.

Department of Gastroenterological Surgery, Higashiosaka City Medical Center, Nishiiwata 3-4-5, Higashiosaka, Osaka, 567-8588, Japan.

Introduction: Enteric duplication cysts are rare and, in addition, isolated enteric duplication cysts are lower morbidity prevalence rate. These cysts lack a connection to the gastrointestinal tract or the adjacent mesenteric vasculature and have only been reported in 10 case reports. In these reports, only two reports were cases with malignant transformation. Read More

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http://dx.doi.org/10.1016/j.ijscr.2018.11.060DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6297057PMC
November 2018
1 Read