211,747 results match your criteria Upper GI Tract

Patient-reported outcomes after oesophagectomy in the multicentre LASER study.

Br J Surg 2021 May 11. Epub 2021 May 11.

Oesophago-gastric Centre, Churchill Hospital, University of Oxford, Oxford, UK.

Background: Data on the long-term symptom burden in patients surviving oesophageal cancer surgery are scarce. The aim of this study was to identify the most prevalent symptoms and their interactions with health-related quality of life.

Methods: This was a cross-sectional cohort study of patients who underwent oesophageal cancer surgery in 20 European centres between 2010 and 2016. Read More

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Acute hemorrhagic cholecystitis with gallbladder rupture and massive intra-abdominal hemorrhage.

Autops Case Rep 2021 Jan 28;11:e2020232. Epub 2021 Jan 28.

University of Michigan, Michigan Medicine, Department of Surgery, Ann Arbor, Michigan, USA.

Acute hemorrhagic cholecystitis is a rare, life-threatening condition that can be further complicated by perforation of the gallbladder. We describe a patient with clinical and radiologic findings of acute cholecystitis with a gallbladder rupture and massive intra-abdominal bleeding. Our patient is a 67-year-old male who presented with an ischemic stroke and was treated with early tissue plasminogen activator. Read More

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January 2021

Gastric amyloidosis in a patient with dysphagia.

Gastroenterol Hepatol Bed Bench 2021 ;14(2):178-180

Department of Gastroenterology, ProMedica Toledo Hospital, Toledo, Ohio, USA.

Dysphagia is a symptom with a broad differential diagnosis. Usually, the etiology of dysphagia is benign, but it is essential to rule out serious causes. It is also critical to think outside the box when the etiology is not obvious. Read More

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January 2021


Georgian Med News 2021 Mar(312):105-113

I. Horbachevsky Ternopil National Medical University, Ukraine.

Aim of the research - comprehensive morphometric assessment of the structural and spatial organization of the circulatory system of the duodenum in obstructive cholestasis in intact animals. Three days after the simulated obstructive cholestasis in 3 experimental animals, on examination of radiographs there is a tendency to reorient the arterial and venous bed of the duodenum. Analysis of morphometric parameters also showed a tendency to constriction of arteries and varicose veins. Read More

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A new intestinal model for analysis of drug absorption and interactions considering physiological translocation of contents.

Drug Metab Dispos 2021 May 7. Epub 2021 May 7.

Graduate School of Pharmaceutical Sciences, Chiba University, Japan

Precise prediction of drug absorption is key to the success of new drug development and efficacious pharmacotherapy. In this study, we developed a new absorption model, the advanced translocation model (ATOM), by extending our previous model, the translocation model. ATOM reproduces the translocation of a substance in the intestinal lumen using a partial differential equation with variable dispersion and convection terms to describe natural flow and micro-mixing within the intestine, under not only fasted but also fed conditions. Read More

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Intraperitoneal Barium From Gastrointestinal Perforations: Reassessment of the Prognosis and Long-Term Effects.

AJR Am J Roentgenol 2021 May 6:1-7. Epub 2021 May 6.

Department of Radiology, NorthShore University HealthSystem, Evanston, IL.

The purpose of this study was to reassess the outcome and potential consequences of intraperitoneal barium leakage during radiologic evaluation of the gastrointestinal tract. This retrospective study included 18 patients who had significant intraperitoneal leakage of barium from gastrointestinal perforations that were not suspected or diagnosed before the radiologic procedures. This complication occurred during a barium enema examination in nine patients, an upper gastrointestinal study in seven, and a small bowel series in two patients. Read More

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Arterio-Duodenal Fistula: A Rare Complication of Laparoscopic Choledochal Cyst Excision.

J Indian Assoc Pediatr Surg 2021 Jan-Feb;26(1):57-59. Epub 2021 Jan 11.

Department of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, Basni, Jodhpur, India.

Choledochal cysts (CDC) are rare biliary tract anomalies characterized by congenital dilatation of the extrahepatic and/or intrahepatic bile ducts. CDC excision with hepatico-enterostomy is the preferred surgery in modern era. Perioperative blood loss in a case of laparoscopic choledochal cyst excision (LCCE) is usually minimal and managed by conservative treatment such as blood transfusion and correction of coagulation factors. Read More

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January 2021

Meckel's diverticulum in an adult with iron deficiency.

Proc (Bayl Univ Med Cent) 2021 Jan 28;34(3):367-368. Epub 2021 Jan 28.

Department of Gastroenterology, State University of New York Upstate Medical University, Syracuse, New York.

Meckel's diverticulum is a true diverticulum caused by the incomplete obliteration of the vitelline duct during gestation. It is the most common congenital malformation of the gastrointestinal tract. Meckel's diverticulum is a rare presentation in adults, especially because symptomatic patients present in early childhood. Read More

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January 2021

Duodenal Microbiota in Stunted Undernourished Children with Enteropathy.

N Engl J Med 2021 05;384(18):1777-1778

Centre Hospitalier Universitaire de Lille, Lille, France

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Duodenal Microbiota in Stunted Undernourished Children with Enteropathy.

Saul Malozowski

N Engl J Med 2021 05;384(18):1777

National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD

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High Rate of Gastrointestinal Bleeding in Patients with Secondary Sclerosing Cholangitis in Critically Ill Patients (SC-CIP).

J Clin Med 2021 Apr 29;10(9). Epub 2021 Apr 29.

Department of Internal Medicine, Division for Gastroenterology and Hepatology, Medical University of Graz, 8036 Graz, Austria.

Secondary sclerosing cholangitis in critically ill patients (SC-CIP) is a rare cholestatic liver disease triggered by long-term intensive care treatment. The aim of this study was to evaluate the frequency and characteristics of gastrointestinal bleeding in SC-CIP. Patients with diagnosed SC-CIP were retrospectively identified and compared to a control group of patients with cardiac surgery and intensive care treatment but without the development of SC-CIP. Read More

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Development of an Objective Scoring System for Endoscopic Assessment of Radiation-Induced Upper Gastrointestinal Toxicity.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Department of Radiation Oncology, Division of Radiation Oncology, University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA.

We developed and implemented an objective toxicity scoring system to be used during endoscopic evaluation of the upper gastrointestinal (GI) tract in order to directly assess changes in toxicity during the radiation treatment of pancreatic cancer. We assessed and validated the upper GI toxicity of 19 locally advanced pancreatic cancer trial patients undergoing stereotactic body radiation therapy (SBRT). Wilcoxon-signed rank tests were used to compare pre- and post-SBRT scores. Read More

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Pembrolizumab-caused polyradiculoneuropathy as an immune-related adverse event.

Neuropathology 2021 May 3. Epub 2021 May 3.

Department of Neurology, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure, Hiroshima, Japan.

Immune-related adverse events (irAEs) commonly involve the gastrointestinal tract, endocrine glands, skin, and liver, and rarely the nervous system. The pathomechanism of irAEs in the nervous system is unclear, and so characterizing these severe toxic effects is a priority, even if irAEs are uncommon in the nervous system. Our patient presented subacute muscle weakness and dysesthesia with colitis as irAEs caused by pembrolizumab, one of the anti-programmed death-1 (PD-1) antibodies. Read More

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Onset of Skin, Gut, and Genitourinary Prodromal Parkinson's Disease: A Study of 1.5 Million Veterans.

Mov Disord 2021 May 3. Epub 2021 May 3.

Department of Neurology, Oregon Health and Science University, Portland, Oregon, USA.

Background: Prodromal Parkinson's disease of skin, genitourinary, and gastrointestinal systems offers a unique window for understanding early disease pathogenesis and developing disease modifying treatments. However, prior studies are limited by incomplete timing information, small sample size, and lack of adjustment for known confounders. Verifying prodromal timing and identifying new disorders in these accessible organs is critically important given their broad use. Read More

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Gastroduodenal amyloidosis: a case report and review of literature.

J Surg Case Rep 2021 Apr 22;2021(4):rjab093. Epub 2021 Apr 22.

College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.

Amyloidosis is a disorder characterized by deposition of abnormally folded proteins in the extracellular space of various tissues and organs, possibly leading to their dysfunction. In the majority of cases, amyloidosis presents with systemic involvement including the gastrointestinal tract; however, localized gastroduodenal amyloidosis is rare. We report a case of gastroduodenal amyloidosis in a 36-year-old male with multiple comorbidities who presented with right upper quadrant abdominal pain. Read More

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Burned-out Post Pubertal Teratoma Presenting as a Liver Metastases in a 34-Year-Old Male.

Iran J Pathol 2021 21;16(2):232-236. Epub 2020 Dec 21.

Department of Pathology, Cancer Institute, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Iran.

Germ cell teratomas belong to non-seminomatous germ cell tumors and account for 95% of malignant testicular tumors. Regarding the current World Health Organization (WHO) criteria, testicular teratomas are divided into prepubertal and post-pubertal subtypes based on patients' age. The term "burned-out testicular tumor" is a very rare condition referring to a regressed testicular tumor which presents with its metastases without any clinical finding in the testicle. Read More

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December 2020

Composite detection rate as an upper gastrointestinal endoscopy quality measure correlating with detection of neoplasia.

J Gastroenterol 2021 May 2. Epub 2021 May 2.

Chair and department of Gastroenterology and Hepatology, School of Medicine in Katowice, Medical University of Silesia, Medyków 14 Street, 40-752, Katowice, Poland.

Background: Esophagogastroduodenoscopy (EGD) is commonly used diagnostic method with no widely accepted quality measure. We assessed quality indicator-composite detection rate (CDR)-consisting of detection of at least one of the following: cervical inlet patch, gastric polyp and post-ulcer duodenal bulb deformation. The aim of the study was to validate CDR according to detection rate of upper gastrointestinal neoplasms (UGN). Read More

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Prediction of Relapse After Anti-Tumor Necrosis Factor Cessation in Crohn's Disease: Individual Participant Data Meta-Analysis of 1317 Patients From 14 Studies.

Clin Gastroenterol Hepatol 2021 Apr 29. Epub 2021 Apr 29.

Department of Gastroenterology and Hepatology. Electronic address:

Background & Aims: Tools for stratification of relapse risk of Crohn's disease (CD) after anti-tumor necrosis factor (TNF) therapy cessation are needed. We aimed to validate a previously developed prediction model from the diSconTinuation in CrOhn's disease patients in stable Remission on combined therapy with Immunosuppressants (STORI) trial, and to develop an updated model.

Methods: Cohort studies were selected that reported on anti-TNF cessation in 30 or more CD patients in remission. Read More

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Gastrointestinal surgery improved the absorption of levodopa in Parkinson's disease.

Parkinsonism Relat Disord 2021 Apr 24;87:20-21. Epub 2021 Apr 24.

Department of Clinical Pharmacology and Therapeutics, Ehime University Graduate School of Medicine, Tohon, Ehime, Japan.

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[Effect of moxibustion and acupuncture on gastric mucosal cell apoptosis and expression of NF-κB, Bcl-2 in chronic atrophic gastritis rats].

Zhen Ci Yan Jiu 2021 Apr;46(4):284-8

Liuyang Hospital of Traditional Chinese Medicine, Liuyang 410300, Hunan Province.

Objective: To observe the effect of moxibustion and acupuncture on apoptosis in gastric mucosal cell and expression of NF-κB, Bcl-2 in chronic atrophic gastritis (CAG) rats, so as to explore its mechanisms underlying improvement of CAG.

Methods: Forty-eight male SD rats were randomly divided into normal, model, moxibustion and acupuncture groups, with 12 rats in each group. The CAG model was established by gavage of N-methyl-N'-nitro-N-nitroso-guanidine (MNNG) solution and irregular diet for 12 weeks. Read More

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Risk factors for complications of therapeutic endoscopy for upper gastrointestinal subepithelial lesions.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2021 Mar;46(3):278-282

Department of Gastroenterology, Third Xiangya Hospital, Central South University, Changsha 410013, China.

Objectives: To study the risk factors for complications after endoscopic therapy for upper gastrointestinal subepithelial lesions (SELs).

Methods: Retrospective analysis was performed on 184 patients in the Department of Gastroenterology in the Third Xiangya Hospital, Central South University after therapeutic endoscopy [endoscopic submucosal dissection (ESD), endoscopic full-thickness resection (EFR), endoscopic submucosal excavation (ESE), and submucosal tunneling endoscopic resection (STER)] for the upper gastrointestinal SELs from 2014-09-01 to 2019-09-30. The clinic data were collected and risk factors for postoperative complications were analyzed. Read More

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Endoscopic assessment of morphological and histopathological upper gastrointestinal changes after endoscopic sleeve gastroplasty.

Surg Obes Relat Dis 2021 Apr 2. Epub 2021 Apr 2.

IHU-Strasbourg, Institute of Image-Guided Surgery, Strasbourg, France; IRCAD, Research Institute against Digestive Cancer, Strasbourg, France; Department of Digestive and Endocrine Surgery, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg, France.

Background: Endoscopic sleeve gastroplasty (ESG) is a promising bariatric endoluminal procedure. Restriction and shortening of the stomach are obtained by means of non-resorbable full-thickness sutures, thus inducing the formation of several endoluminal pouches in which food can stagnate. The effect of ESG on the upper gastrointestinal tract has never been investigated. Read More

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Effect of Multi-Strain Probiotic Supplementation on URTI Symptoms and Cytokine Production by Monocytes after a Marathon Race: A Randomized, Double-Blind, Placebo Study.

Nutrients 2021 Apr 27;13(5). Epub 2021 Apr 27.

Department of Bioscience, Universidade Federal de São Paulo, Santos 11015-020, Brazil.

(1) Purpose: Performing strenuous exercises negatively impacts the immune and gastrointestinal systems. These alterations cause transient immunodepression, increasing the risk of minor infections, especially in the upper respiratory tract. Recent studies have shown that supplementation of probiotics confers benefits to athletes. Read More

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Gastroprotective Effects of Polyphenols against Various Gastro-Intestinal Disorders: A Mini-Review with Special Focus on Clinical Evidence.

Molecules 2021 Apr 6;26(7). Epub 2021 Apr 6.

School of Nutrition, Chung Shan Medical University, 110, Section. 1, Jianguo North Road, Taichung 40201, Taiwan.

Polyphenols are classified as an organic chemical with phenolic units that display an array of biological functions. However, polyphenols have very low bioavailability and stability, which make polyphenols a less bioactive compound. Many researchers have indicated that several factors might affect the efficiency and the metabolism (biotransformation) of various polyphenols, which include the gut microbiota, structure, and physical properties as well as its interactions with other dietary nutrients (macromolecules). Read More

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Endocannabinoids and the Gut-Brain Control of Food Intake and Obesity.

Nutrients 2021 Apr 7;13(4). Epub 2021 Apr 7.

Division of Biomedical Sciences, School of Medicine, University of California Riverside, Riverside, CA 92521, USA.

Gut-brain signaling controls food intake and energy homeostasis, and its activity is thought to be dysregulated in obesity. We will explore new studies that suggest the endocannabinoid (eCB) system in the upper gastrointestinal tract plays an important role in controlling gut-brain neurotransmission carried by the vagus nerve and the intake of palatable food and other reinforcers. A focus will be on studies that reveal both indirect and direct interactions between eCB signaling and vagal afferent neurons. Read More

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Refractory Immune Checkpoint Inhibitor-Induced Colitis Improved by Tacrolimus: A Case Report.

Healthcare (Basel) 2021 Apr 5;9(4). Epub 2021 Apr 5.

Department of Gastroenterology, Dokkyo Medical University, Tochigi 321-0293, Japan.

Immune checkpoint inhibitors (ICIs) increase T-cell activity and antitumor immune response. However, they also have immune-related adverse effects that can affect the gastrointestinal (GI) tract. A 62-year-old male patient who had undergone right lung upper lobectomy for adenocarcinoma of the lung received chemotherapy with pemetrexed sodium hydrate, carboplatin, and pembrolizumab to prevent postoperative recurrence of liver metastasis. Read More

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Preoperative Diagnosis Failure for a Rare Gastric Collision Tumor: A Case Report.

Diagnostics (Basel) 2021 Apr 1;11(4). Epub 2021 Apr 1.

Department of Pharmacology & Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia 41522, Egypt.

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors of the gastrointestinal tract (GIT), usually occur as a solitary neoplasm. Inflammatory florid polyp (IFP) is a solitary rare benign lesion of the gastrointestinal tract, mainly occur in the gastric antrum, whose atypical presentation can mimic GISTs or other malignant tumors, therefore the synchronous occurrence of GISTs and IFP is extremely rare. We had a case of a 58-year-old man that was presented with recurrent epigastric pain and recurrent melena. Read More

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Intragastric Single-Port Surgery: An Innovative and Multipurpose Technique for the Therapy of Upper Digestive Tract Lesions.

Surg Innov 2021 Apr 29:15533506211015386. Epub 2021 Apr 29.

Center for Bariatric and Metabolic Surgery, 14959Klinikum Ernst von Bergmann, Academic Hospital of the Charité-Universitätsmedizin Humboldt University Berlin, Potsdam, Germany.

: Endoscopic treatment can represent a technical challenge for several special situations, such as resecting gastric tumors with larger size or in unfavorable sites and performing endoscopic retrograde cholangiopancreatography (ERCP) after Roux-en-Y gastric bypass (RYGB). This study aims to describe an innovative and multipurpose technique, intragastric single-port surgery (IGS), which can be applied for abovementioned special situations and for assessing its safety, feasibility, and efficacy. : IGS technique was performed through a 2-3 cm skin incision, where the stomach wall is exteriorized and fixed to the skin. Read More

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