217,233 results match your criteria Upper GI Tract

Design, synthesis and evaluation of alpha lipoic acid derivatives to treat multiple sclerosis-associated central neuropathic pain.

Bioorg Med Chem 2022 Jun 20;69:116889. Epub 2022 Jun 20.

School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, Queensland 4072, Australia. Electronic address:

Multiple sclerosis-associated central neuropathic pain (MS-CNP) is difficult to alleviate with clinically used pain-killers and so there is a large unmet medical need for novel treatments for alleviating MS-CNP. Although (R)-alpha lipoic acid (ALA) evoked significant pain relief efficacy in a mouse model of multiple sclerosis-associated central neuropathic pain (MS-CNP), this dietary supplement has poor oral bioavailability due to low gastric stability. Eight ester prodrugs of the R enantiomer of ALA [(R)-ALA] were designed encompassing a range of biocompatible hydrophobic and hydrophilic features and synthesized in an effort to identify a prodrug candidate that was stable at gastric and upper gastrointestinal tract (GIT) pH, and that could be released (hydrolyzed by esterases) in the blood to (R)-ALA immediately after absorption into the portal vein (i. Read More

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Which ICU patients need stress ulcer prophylaxis?

Cleve Clin J Med 2022 Jul 1;89(7):363-367. Epub 2022 Jul 1.

Department of Pulmonary Medicine and Department of Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland, OH.

Critically ill patients are at an increased risk for developing stress ulcers of the mucosa of the upper gastrointestinal (GI) tract. Bleeding from stress ulcers was previously associated with a longer stay in the intensive care unit and an increased risk of death. Thus, most patients admitted to the intensive care unit receive stress ulcer prophylaxis. Read More

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Protein-Losing Enteropathy Resolved by Eradication.

Eur J Case Rep Intern Med 2022 26;9(5):003312. Epub 2022 May 26.

Department of Internal Medicine, Hospital Garcia de Orta, Almada, Lisbon, Portugal.

Protein-losing enteropathy (PLGE) is an uncommon condition with a multifactorial origin, that is characterized by excessive loss of serum proteins into the gastrointestinal tract, resulting in hypoproteinaemia and oedema. The authors present the case of a 24-year-old man admitted to hospital for a 2-month history of lower extremity oedema and diarrhoea with a secretory pattern. Blood analysis revealed hypoalbuminaemia and iron deficiency anaemia. Read More

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Case Report: Successful Repair of Primary Aortoesophageal Fistula With an Endovascular Stent Graft and an Esophageal Stent.

Front Surg 2022 14;9:868663. Epub 2022 Jun 14.

Department of Emergency, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Aortoesophageal fistula (AEF), secondary to thoracic pseudoaneurysm as a result of upper gastrointestinal bleeding, is a rare condition and will be undoubtedly lethal without prompt surgical intervention. The estimated annual incidence of primary AEFs and secondary AEFs is about 0.0015% and 0. Read More

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Intrapyloric Botulinum Toxin A Injection for Gastroparesis and Functional Upper Gastrointestinal Symptoms in Children: Mayo Clinic Experience, Review of the Literature, and Meta-analysis.

Paediatr Drugs 2022 Jun 30. Epub 2022 Jun 30.

Division of Pediatric Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Objective: We aimed to assess the efficacy of intrapyloric botulinum toxin A injection (IPBTI) in children with and without gastroparesis and to perform a meta-analysis and review of the literature.

Methods: We retrospectively searched our electronic health records to identify children (aged < 18 years) who underwent an esophagogastroduodenoscopy with IPBTI between 2007 and 2018 for persistent upper gastrointestinal tract symptoms. We included children with and without gastroparesis and excluded children with a history of gastrointestinal surgery, gastrointestinal obstruction, or mucosal disease that could explain their symptoms. Read More

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[Relationship between gastric mucosal cholesterol and infection and its immune evasion mechanism].

Y H Wu M Z Jiang

Zhonghua Er Ke Za Zhi 2022 Jul;60(7):719-722

Pediatric Endoscopy Center and Department of Gastroenterology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou 310052, China.

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Helicobacter pylori pathogen inhibits cellular responses to oncogenic stress and apoptosis.

PLoS Pathog 2022 Jun 29;18(6):e1010628. Epub 2022 Jun 29.

Department of Surgery, Miller School of Medicine, University of Miami, Miami, Florida, United States of America.

Helicobacter pylori (H. pylori) is a common gastric pathogen that infects approximately half of the world's population. Infection with H. Read More

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Arq Bras Cir Dig 2022 24;35:e1666. Epub 2022 Jun 24.

Faculdade de Medicina da Universidade Federal de Minas Gerais, Departamento de Cirurgia, Belo Horizonte - MG - Brazil.

Aim: Knowledge of the portal system and its anatomical variations aids to prevent surgical adverse events. The portal vein is usually made by the confluence of the superior mesenteric and splenic veins, together with their main tributaries, the inferior mesenteric, left gastric, and pancreaticoduodenal veins; however, anatomical variations are frequent. This article presents a literature review regarding previously described anatomical variations of the portal venous system and their frequency. Read More

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Arq Bras Cir Dig 2022 24;35:e1665. Epub 2022 Jun 24.

Hospital das Clínicas da Universidade Federal de Pernambuco, General Surgery Service - Recife - PE, Brazil.

Objective: The twisting of the gastric tube is one of the main causes of persistent reflux and food intolerance after sleeve gastrectomy (SG). To date, there is no classification for gastric twist after SG. This study aimed to propose an endoscopic classification for this condition and outline the clinical profile of these patients with sleeve gastrectomy. Read More

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Arq Bras Cir Dig 2022 24;35:e1661. Epub 2022 Jun 24.

Center for the Diagnosis of the Digestive System Diseases - Gastrocentro - Unicamp, Campinas, São Paulo, Brazil.

Aim: Esophagogastroduodenoscopies and colonoscopies are the main diagnostic examinations for esophageal, stomach, and colorectal tumors. This study aimed to evaluate the estimates of the incidence of esophageal, stomach, and colorectal cancer; population growth; and esophagogastroduodenoscopies and colonoscopies performed by the Unified Health System (SUS), from 2010 to 2018, in the five regions of the country, and to analyze the relationship between these values.

Results: The colorectal tumor had a significant elevation, while the esophageal and gastric maintained the incidences. Read More

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Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends.

J Mater Chem B 2022 Jun 29. Epub 2022 Jun 29.

Nanotechnology and Biodelivery Laboratory, Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA.

Oral colon-targeted delivery systems (OCDSs) have attracted great attention in the delivery of active compounds targeted to the colon for the treatment of colon and non-colon diseases with the advantages of enhanced efficacy and reduced side effects. Chitosan, the second-most abundant biopolymer next to cellulose, has great biocompatibility, is non-toxic, is sensitive to colonic flora and shows strong adhesion to colonic mucus, making it an ideal biomaterial candidate for the construction of OCDSs. Being rich in functional groups, the chitosan structure is easily modified, both physically and chemically, for the fabrication of delivery systems with diverse geometries, including nanoparticles, microspheres/microparticles, and hydrogels, that are resistant to the harsh environment of the upper gastrointestinal tract (GIT). Read More

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Case report: two cases of spontaneous intramural duodenal hematoma associated with pancreatitis.

Acta Biomed 2022 Jun 29;93(S1):e2022226. Epub 2022 Jun 29.

Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia.

Intramural duodenal hematoma (IDH) is a rare entity and is generally associated with trauma. Spontaneous (nontraumatic) intramural duodenal hematoma is associated with bleeding disorders, anticoagulation therapy, alcoholism, pancreatitis, tumours  and duodenal ulcers. We report two cases of spontaneous intramural duodenal hematoma in middle-aged men who subsequently developed pancreatitis. Read More

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Transthoracic, thoracoabdominal, and transabdominal surgical approaches for gastric cardia adenocarcinomas: a survival evaluation based on a cohort of 7103 patients.

World J Surg Oncol 2022 Jun 28;20(1):217. Epub 2022 Jun 28.

State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of The First Affiliated Hospital, Zhengzhou University, Zhengzhou, 450052, Henan Province, China.

Background: This study compared the survival outcomes of different surgical approaches to determine the optimal approach for gastric cardia adenocarcinoma (GCA) and aimed to standardize the surgical treatment guidelines for GCA.

Methods: A total of 7103 patients with GCA were enrolled from our previously established gastric cardia and esophageal carcinoma databases. In our database, when the epicenter of the tumor was at or within 2 cm distally from the esophagogastric junction, the adenocarcinoma was considered to originate from the cardia and was considered a Siewert type 2 cancer. Read More

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A study protocol of a randomized phase II trial of perioperative chemoimmunotherapy verses perioperative chemoimmunotherapy plus preoperative chemoradiation for locally advanced gastric (G) or gastroesophageal junction (GEJ) adenocarcinoma: the NeoRacing study.

BMC Cancer 2022 Jun 28;22(1):710. Epub 2022 Jun 28.

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, 270 Dong'an Road, Shanghai, 200032, People's Republic of China.

Background: Perioperative chemotherapy (ChT) and preoperative chemoradiation (CRT) are both the standard treatments for locally advanced gastric cancer (LAGC). CRT can achieve a higher pathological complete regression (pCR) rate, but whether this higher pCR rate can be transformed into a long-term survival benefit remains inconclusive. Therefore, relevant studies are in progress. Read More

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[Clinical characteristics of 500 hospitalized patients with liver cirrhosis: a retrospective analysis from a tertiary hospital in Beijing].

Zhonghua Gan Zang Bing Za Zhi 2022 May;30(5):541-545

Department of Infectious Diseases, Peking University First Hospital, Beijing 100034, China.

To understand the clinical characteristics of hospitalized patients with liver cirrhosis, so as to provide theoretical basis for disease diagnosis and treatment, formulation of intervention measures, and improve the level of disease diagnosis and treatment. Hospitalized patients who were initially diagnosed with liver cirrhosis at Peking University First Hospital from August 2017 to December 2018 were selected retrospectively as the research objects. Liver cirrhosis demographic data, etiology, severity classification, incidence of complications, diagnosis and prognosis were recorded. Read More

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[Transcutaneous auricular vagus nerve stimulation promotes gastric motility by up-rgulating α7nAChR and suppressing NF-κB p65 expression in duodenum in rats with functional dyspepsia].

Zhen Ci Yan Jiu 2022 Jun;47(6):517-24

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China.

Objective: To study the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on gastric sensitivity and motility in rats with functional dyspepsia (FD), so as to explore its underlying mechanism in improving FD.

Methods: A total of 48 young SD rats were randomly divided into control (=10), model (=9), taVNS (=9), subdiaphragmatic vagus nerve stimulation (SDVNS, =9) and sham SDVNS (=7) groups. The FD model was established by gavage of 0. Read More

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Functional luminal imaging probe in the evaluation of esophago-gastric junction outflow obstruction.

Curr Opin Gastroenterol 2022 Jul;38(4):388-394

Division of Gastroenterology, Center for Esophageal Diseases, Baylor University Medical Center, Baylor Scott & White, Dallas, Texas, USA.

Purpose Of Review: Esophagogastric junction outflow obstruction (EGJOO) comprises a heterogeneous group of conditions that demonstrate impaired deglutitive relaxation of the esophagogastric junction (EGJ) with intact esophageal peristalsis on high-resolution manometry. Functional luminal imaging probe (FLIP) panometry is a powerful tool that can help to clarify the etiology of this manometric diagnosis. The aim of this review is to summarize the use of FLIP for the evaluation and management of EGJOO. Read More

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In vitro digestion of tofu with different textures using an artificial gastric digestive system.

Food Res Int 2022 Jul 4;157:111458. Epub 2022 Jun 4.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, PR China. Electronic address:

Two kinds of tofu with obvious differences in texture ["GDL" and "CaSO", standing for tofus made with the application of either glucono-δ-lactone (GDL) or calcium sulfate, with measured hardness 23.1 ± 3.3 g and 105. Read More

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In silico modelling of protein digestion: A case study on solid/liquid and blended meals.

Food Res Int 2022 Jul 20;157:111271. Epub 2022 Apr 20.

Food Process Engineering, Wageningen University, 6700 AA Wageningen, the Netherlands. Electronic address:

We present a dynamic, semi-mechanistic, compartmental protein digestion model to study the kinetics of protein digestion. The digestive system is described as a series of eight compartments: one for the stomach, one for the duodenum, two for the jejunum and four for the ileum. The digestive processes are described by a set of zero or first order differential equations. Read More

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Contribution of the proximal and distal gastric phases to the breakdown of cooked starch-rich solid foods during static in vitro gastric digestion.

Food Res Int 2022 Jul 20;157:111270. Epub 2022 Apr 20.

Riddet Institute, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand; Department of Biological and Agricultural Engineering, University of California, Davis, CA 95618, USA. Electronic address:

In vitro gastric digestion studies commonly focus on the acidic environment of the stomach (the distal phase), neglecting that the contact time between food and salivary amylase can be extended during bolus' temporary storage in the proximal stomach (the proximal phase). Consequently, the role of the proximal phase of gastric digestion on the breakdown of solid starch-based foods is not well understood. This study aimed to address this question using a static in vitro digestion approach. Read More

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In vivo experimental validation of detection of gastric slow waves using a flexible multichannel electrogastrography sensor linear array.

Biomed Eng Online 2022 Jun 27;21(1):43. Epub 2022 Jun 27.

University of Auckland, Auckland, New Zealand.

Background: Cutaneous electrogastrography (EGG) is a non-invasive technique that detects gastric bioelectrical slow waves, which in part govern the motility of the stomach. Changes in gastric slow waves have been associated with a number of functional gastric disorders, but to date accurate detection from the body-surface has been limited due to the low signal-to-noise ratio. The main aim of this study was to develop a flexible active-electrode EGG array. Read More

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Mucus-Penetrating Alginate-Chitosan Nanoparticles Loaded with Berberine Hydrochloride for Oral Delivery to the Inflammation Site of Ulcerative Colitis.

AAPS PharmSciTech 2022 Jun 27;23(6):179. Epub 2022 Jun 27.

Anhui Province Key Laboratory of Pharmaceutical Technology and Application, Key Laboratory of Xin'an Medicine Ministry of Education, Anhui Province Key Laboratory of Chinese Medicinal Formula, Anhui University of Chinese Medicine, Hefei, 230038, Anhui, China.

The rectal enemas of berberine hydrochloride (BH) have emerged as one of the most effective strategies in the clinical treatment of ulcerative colitis (UC). However, oral dosages of BH exhibit a poor anti-inflammatory effect of UC, which may attribute to premature absorption of BH by the upper gastrointestinal tract. Moreover, the thick colonic mucus layer obstructs the penetration of the drug, resulting in low bioavailability to the inflammatory site of the colon. Read More

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Acute kidney injury secondary to urinary tract infection in kidney transplant recipients.

Sci Rep 2022 Jun 27;12(1):10858. Epub 2022 Jun 27.

Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wrocław, 50-556, Poland.

Acute kidney injury (AKI) in kidney transplant recipients (KTRs) is a common, yet poorly investigated, complication of urinary tract infections (UTI) and urosepsis. A retrospective comparative analysis was performed, recruiting 101 KTRs with urosepsis, 100 KTRs with UTI, and 100 KTRs without history of UTI or sepsis. The incidences of AKI in the urosepsis and UTI groups were 75. Read More

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Diagnoses after newly recorded abdominal pain in primary care: observational cohort study.

Br J Gen Pract 2022 Apr 20. Epub 2022 Apr 20.

Cancer Diagnosis (DISCO), University of Exeter Medical School, Exeter.

Background: Non-acute abdominal pain in primary care is diagnostically challenging.

Aim: To quantify the 1-year cumulative incidence of 35 non-malignant diagnoses and nine cancers in adults after newly recorded abdominal pain in primary care.

Design And Setting: Observational cohort study of 125 793 Clinical Practice Research Datalink GOLD records. Read More

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A Study of Postoperative Complications Occurring at Home With Pediatric Gastrostomy Feeding Tubes.

J Pediatr Gastroenterol Nutr 2022 Jul 28;75(1):30-35. Epub 2022 Apr 28.

Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD.

Objective: Gastrostomy tubes (G-tubes) provide long-term feeding assistance to children with severe feeding dysfunction. Although there are a host of complications that occur at home with current pediatric G-tube feeding, their prevalences and outcomes remain relatively unstudied. This study aims to identify and describe such complications. Read More

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Lower gastrointestinal bleeding in a male with jejunal Dieulafoy's lesion after successful surgical resection: A case report and literature review.

Medicine (Baltimore) 2022 Jun 24;101(25):e29474. Epub 2022 Jun 24.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan.

Introduction: Dieulafoy's lesion (DL) presented with small bowel bleeding constitutes a group of rare and potentially life-threatening prognosis. Several case series have described this condition, yet it remains unclear as to what is the optimal treatment and predicted outcome for patients who have been diagnosed.

Patient Concerns: We present a 21-year-old male experiencing bloody stool for 1 day. Read More

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Artificial Intelligence-Assisted Endoscopic Diagnosis of Early Upper Gastrointestinal Cancer: A Systematic Review and Meta-Analysis.

Front Oncol 2022 10;12:855175. Epub 2022 Jun 10.

Department of Hepatobiliary Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Objective: The aim of this study was to assess the diagnostic ability of artificial intelligence (AI) in the detection of early upper gastrointestinal cancer (EUGIC) using endoscopic images.

Methods: Databases were searched for studies on AI-assisted diagnosis of EUGIC using endoscopic images. The pooled area under the curve (AUC), sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), and diagnostic odds ratio (DOR) with 95% confidence interval (CI) were calculated. Read More

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Huaier Inhibits Gastric Cancer Growth and Hepatic Metastasis by Reducing Syntenin Expression and STAT3 Phosphorylation.

J Oncol 2022 15;2022:6065516. Epub 2022 Jun 15.

The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Institutes of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou 310022, China.

Gastric cancer (GC) is a common malignant tumor worldwide and poses a serious threat to human health. As a traditional Chinese medicine, Huaier ( Murr.) has been used in the clinical treatment of GC. Read More

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An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer.

Gynecol Oncol Rep 2022 Aug 10;42:101017. Epub 2022 Jun 10.

University of North Carolina at Chapel Hill, Department of Medicine, Center for Gastrointestinal Biology and Disease, United States.

Objective: The microbiome of the female upper reproductive tract (URT) has not been characterized. We hypothesize that distinct bacterial species may be identified in different areas of the URT in women with or without ovarian cancers.

Methods: Postmenopausal women scheduled for salpingooophorectomy were prospectively identified. Read More

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Iron pill-induced gastritis - An unrecognized side of iron-deficiency anemia.

Rev Esp Enferm Dig 2022 Jun 24. Epub 2022 Jun 24.

Gastrenterology, Centro Hospitalar e Universitário de Coimbra, Portugal.

Iron-deficiency anemia is a prevalent condition usually treated with iron supplementation. Iron pill-induced gastritis is an under-recognized, albeit serious potential complication of iron pill ingestion in the upper gastrointestinal tract. This entity must be identified by healthcare providers who prescribe iron. Read More

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