203,520 results match your criteria Upper GI Tract


Hospital Care and Surgical Treatment of Children with Congenital Upper Limb Defects.

Scand J Surg 2019 Mar 20:1457496919835988. Epub 2019 Mar 20.

3 Section of Paediatric Surgery, Hospital for Children and Adolescents, Helsinki University Central Hospital, Helsinki, Finland.

Background And Aims:: To evaluate hospital care of children with congenital upper limb defects.

Materials And Methods:: Three hundred and sixty-two children with an upper limb defect, born 1993-2005, and alive after birth admission were identified in the Finnish Register of Congenital Malformations. The data on hospital care, with focus on operative treatment, were collected from the National Hospital Discharge Register, until 31 December 2009. Read More

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http://dx.doi.org/10.1177/1457496919835988DOI Listing

Management of foreign body ingestion and food impaction in adults: A cross-sectional study.

Ulus Travma Acil Cerrahi Derg 2019 Mar;25(2):159-166

Department of General Surgery, Gaziosmanpaşa University Faculty of Medicine, Tokat-Turkey.

Background: The management of food impaction and foreign body ingestion in the upper gastrointestinal tract requires careful evaluation and timely intervention. This study was a retrospective evaluation of the management of adult patients with such a history.

Methods: This study included adult patients admitted to a tertiary medical center with foreign body ingestion or food impaction between January 2012 and January 2018. Read More

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http://dx.doi.org/10.5505/tjtes.2018.67240DOI Listing

Crohn's disease of esophagus, stomach and duodenum.

World J Gastrointest Pharmacol Ther 2019 Mar;10(2):35-49

Programa de Pós graduação em Medicina e Saúde, Universidade Federal da Bahia, Salvador 40110-060, Bahia, Brazil.

Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. Read More

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http://dx.doi.org/10.4292/wjgpt.v10.i2.35DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422852PMC

INFOGEST static in vitro simulation of gastrointestinal food digestion.

Nat Protoc 2019 Mar 18. Epub 2019 Mar 18.

Instituto de Investigación en Ciencias de la Alimentación (CIAL, CSIC-UAM), Madrid, Spain.

Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus developed by the COST INFOGEST network. Read More

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http://dx.doi.org/10.1038/s41596-018-0119-1DOI Listing

Use of ribaxamase (SYN-004), a β-lactamase, to prevent Clostridium difficile infection in β-lactam-treated patients: a double-blind, phase 2b, randomised placebo-controlled trial.

Lancet Infect Dis 2019 Mar 15. Epub 2019 Mar 15.

Synthetic Biologics, Rockville, MD, USA.

Background: Infections with Clostridium difficile are a health threat, yet no products are currently licensed for prevention of primary C difficile infections. Intravenous β-lactam antibiotics are considered to confer a high risk of C difficile infection because of their biliary excretion into the gastrointestinal tract and disruption of the gut microbiome. ribaxamase (SYN-004) is an orally administered β-lactamase that was designed to be given with intravenous β-lactam antibiotics to degrade excess antibiotics in the upper gastrointestinal tract before they disrupt the gut microbiome and lead to C difficile infection. Read More

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http://dx.doi.org/10.1016/S1473-3099(18)30731-XDOI Listing

How dyspepsia led to the diagnosis of Morbus Crohn.

Acta Clin Belg 2019 Mar 18:1-3. Epub 2019 Mar 18.

b Department of Gastroenterology , University hospital Gasthuisberg , Leuven , Belgium.

Background: It is well known that Crohn's disease can involve the stomach. However, most often this upper gastrointestinal tract involvement is asymptomatic. Typically, there is involvement of the small intestine with the typical associated symptoms of Crohn's disease: abdominal cramps, diarrhoea and weight loss. Read More

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http://dx.doi.org/10.1080/17843286.2019.1590497DOI Listing

Various addiction patterns, dietary habits, associated medical problems, and socioeconomic status in gastrointestinal malignancies: A prospective study in rural area of Maharashtra, India.

J Cancer Res Ther 2019 Jan-Mar;15(1):104-107

Department of Radiotherapy and Oncology, Rural Medical College, Pravara Institute of Medical Sciences, Ahmednagar, Maharashtra, India.

Background: Gastrointestinal (GI) malignancies are increasing with advancing age. Various addictions and poor dietary habits are among the major risk factors. Early detection is difficult until patient notices symptoms. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_925_17DOI Listing

A rare cause of abdominal pain with fever.

BMJ Case Rep 2019 Mar 16;12(3). Epub 2019 Mar 16.

Internal Medicine, Hospital and University Center of Coimbra, Coimbra, Portugal.

An 89-year-old man presented to the emergency department with a 1-month history of upper right quadrant pain, worsened in the last 3 days and accompanied by fever and chills. On physical examination, he had scleral icterus and right upper quadrant tenderness. Laboratory findings showed hyperbilirubinemia, elevated liver enzymes and C reactive protein. Read More

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http://dx.doi.org/10.1136/bcr-2018-228401DOI Listing

Rare complication of milk-alkali ingestion: severe pancreatitis and acute kidney injury in a chronic hypocalcaemic patient with DiGeorge's syndrome.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

Department of Internal Medicine, St Vincent Charity Medical Center, Cleveland, Ohio, USA.

Injudicious use of over-the-counter calcium supplements has resulted in increased incidences of hypercalcaemia and related complications. We present a case of acute pancreatitis in a chronic hypocalcaemic patient of DiGeorge's syndrome. The patient came into the ED with sepsis syndrome, right upper quadrant and epigastric pain and no obvious source of infection. Read More

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http://dx.doi.org/10.1136/bcr-2018-226761DOI Listing

Lanthanum phosphate binder-induced iron deficiency anaemia.

BMJ Case Rep 2019 Mar 15;12(3). Epub 2019 Mar 15.

US Air Force Hospital Keesler AFB, Keesler AFB, Mississippi, USA.

Lanthanum carbonate is a phosphate binder that is used to reduce serum phosphate levels in patients with end-stage renal disease (ESRD). Lanthanum forms insoluble lanthanum phosphate complexes that are supposed to pass through the gastrointestinal (GI) tract unabsorbed. Phosphate binders have been reported to deposit in the GI tract and can cause mucosal injury. Read More

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http://dx.doi.org/10.1136/bcr-2018-226157DOI Listing

Circulating Inflammation Markers and Risk of Gastric and Esophageal Cancers: A Case-Cohort Study Within the Japan Public Health Center-Based Prospective Study.

Cancer Epidemiol Biomarkers Prev 2019 Mar 15. Epub 2019 Mar 15.

Division of Cancer Epidemiology and Genetics, NCI, Rockville, Maryland.

Circulating inflammation proteins may be important mediators or markers of carcinogenic mechanisms. There have been few studies with limited numbers of analytes in patients with upper gastrointestinal (GI) tract tumors. We therefore evaluated risk associations of gastric and esophageal cancers with prediagnostic levels of a wide range of these molecules. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-18-1157DOI Listing

Gastric cancer and paraneoplastic dermatomyositis as complications of an unrecognized juvenile polyposis syndrome.

Z Gastroenterol 2019 Mar 14. Epub 2019 Mar 14.

Department of Medicine II, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Juvenile polyposis syndrome is a rare autosomal-dominant disorder characterized by multiple hamartomatous polyps in the gastrointestinal tract. It is associated with an increased risk of gastrointestinal cancer. We report the case of a 49-year-old woman presenting with proximal muscle weakness, weight loss, severe anemia, and melena. Read More

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http://dx.doi.org/10.1055/a-0855-4404DOI Listing
March 2019
1 Read

Rare Complication of Botox Injection: A Case Report.

World J Plast Surg 2019 Jan;8(1):116-119

Department of Surgery, Iran University of Medical Science, Tehran, Iran.

Botulinum toxin (BTX) is also well-known as Botox is produced by a gram-positive anaerobic bacterium called Generally, clinical manifestations of BTX can be observed after consumption of contaminated food, from colonization of the infant gastrointestinal tract, as well as following the infection of the wound to this bacterium. There are seven types of this neurotoxin labeled as A, B, C (C1, C2), D, E, and F. Human botulinum is caused by types A, B, E and rarely F. Read More

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http://dx.doi.org/10.29252/wjps.8.1.116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409137PMC
January 2019
1 Read

Upper gastrointestinal pathophysiology due to mouse malaria ANKA infection.

Trop Med Health 2019 4;47:18. Epub 2019 Mar 4.

1Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, 3311-1, Yakushiji, Shimotsuke City, Tochigi 329-0498 Japan.

Background: Epigastric pain, vomiting, and other gastrointestinal problems are among the most important symptoms of malaria infection as they suggest the possibility that the condition is serious. Pathophysiologies such as gastric mucosal changes and delayed gastric emptying have been reported in serious cases of malaria infection. However, it is unclear whether or not pathophysiological involvement of the upper gastrointestinal tract occurs in ANKA (PbA)-infected mice. Read More

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http://dx.doi.org/10.1186/s41182-019-0146-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399856PMC

Common midwife toad ranaviruses replicate first in the oral cavity of smooth newts (Lissotriton vulgaris) and show distinct strain-associated pathogenicity.

Sci Rep 2019 Mar 14;9(1):4453. Epub 2019 Mar 14.

Utrecht University, Utrecht, the Netherlands.

Ranavirus is the second most common infectious cause of amphibian mortality. These viruses affect caudates, an order in which information regarding Ranavirus pathogenesis is scarce. In the Netherlands, two strains (CMTV-NL I and III) were suspected to possess distinct pathogenicity based on field data. Read More

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http://dx.doi.org/10.1038/s41598-019-41214-0DOI Listing
March 2019
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The prognostic value of sarcopenia in patients with surgically treated urothelial carcinoma: A systematic review and meta-analysis.

Eur J Surg Oncol 2019 Mar 7. Epub 2019 Mar 7.

Department of Urology, West China Hospital, West China Medical School, Sichuan University, 37 Guoxue Street, Chengdu, 610041, PR China. Electronic address:

Objective: Sarcopenia is associated with unfavorable prognosis in patients undergoing surgical treatments of the respiratory tract, gastrointestinal tract and urinary tracts. We summarized all available evidence to investigate the prognostic value of sarcopenia in patients with surgically treated urothelial carcinoma (UC).

Methods: We conducted a comprehensive study search up to January 2019, searching the online database Embase, PubMed and Cochrane Library. Read More

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http://dx.doi.org/10.1016/j.ejso.2019.03.003DOI Listing

Predicting lab values for gastrointestinal bleeding patients in the intensive care unit: A comparative study on the impact of comorbidities and medications.

Artif Intell Med 2019 Mar 23;94:79-87. Epub 2019 Jan 23.

Department of Computer Engineering, Yazd University, Yazd, Iran. Electronic address:

Since a significant number of frequent laboratory blood tests are unnecessary and these tests may have complications, developing a system that could identify unnecessary tests is essential. In this paper, a value prediction approach is presented to predict the values of Calcium and Hematocrit laboratory blood tests for upper gastrointestinal bleeding patients and patients with unspecified hemorrhage in their gastrointestinal tract. The data have been extracted from the MIMIC-II database. Read More

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http://dx.doi.org/10.1016/j.artmed.2019.01.004DOI Listing
March 2019
2 Reads

Potential Functions of the Gastrointestinal Microbiome Inhabiting the Length of the Rat Digest Tract.

Int J Mol Sci 2019 Mar 12;20(5). Epub 2019 Mar 12.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.

The rat is an important model animal used frequently in biological researches exploring the correlations between gut microbiome and a wide array of diseases. In this study, we used an extended ancestral-state reconstruction algorithm to predict the functional capabilities of the rat gastrointestinal microbiome. Our results indicate an apparent tendency toward metabolic heterogeneity along the longitudinal and transverse axes of the rat gastrointestinal tract (GIT). Read More

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http://dx.doi.org/10.3390/ijms20051232DOI Listing

[Operative treatment of non-malignant esophageal perforations - a summary of our experiences].

Magy Seb 2019 Mar;72(1):3-7

I. sz. Sebészeti Klinika, Semmelweis Egyetem 1082 Budapest, Üllői út 78.

Introduction: Despite significant development in surgical and intensive therapy, esophageal perforation is still a severe, life-threatening condition. Successful therapy depends on several clinical factors, available medical equipments, but most of all on the available expertise and experience.

Patients And Methods: We retrospectively evaluated patients' data operated at the 1st Department of Surgery at Semmelweis University between 2005 and 2017 due to esophageal perforation of non-malignant origin. Read More

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https://www.akademiai.com/doi/10.1556/1046.72.2019.1.1
Publisher Site
http://dx.doi.org/10.1556/1046.72.2019.1.1DOI Listing
March 2019
2 Reads

Spatial and Temporal Analysis of the Stomach and Small-Intestinal Microbiota in Fasted Healthy Humans.

mSphere 2019 Mar 13;4(2). Epub 2019 Mar 13.

Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, Michigan, USA

Although the microbiota in the proximal gastrointestinal (GI) tract have been implicated in health and disease, much about these microbes remains understudied compared to those in the distal GI tract. This study characterized the microbiota across multiple proximal GI sites over time in healthy individuals. As part of a study of the pharmacokinetics of oral mesalamine administration, healthy, fasted volunteers ( = 8; 10 observation periods total) were orally intubated with a four-lumen catheter with multiple aspiration ports. Read More

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http://dx.doi.org/10.1128/mSphere.00126-19DOI Listing

Comparison of Argon Plasma Coagulation and Injection Therapy with Adrenalin and Polidocanol in the Management of Bleeding Angiodysplasia in Upper Gastrointestinal Tract.

Pril (Makedon Akad Nauk Umet Odd Med Nauki) 2018 Dec;39(2-3):63-68

University Children's Hospital, Medical Faculty Skopje, Republic of Macedonia.

Introduction: The term angiodysplasia (AD) refers to acquired malformation of the blood vessels (communications between veins and capillaries), frequently found within the gastrointestinal mucosa and submucosa. AD of stomach and duodenum are cause of upper gastrointestinal bleeding in 4%-7% of patients. The means of treatment are usually endoscopic, including argon plasma coagulation (APC), electrocoagulation, mechanical hemostasis by clippsing, laser photo-coagulation and injection therapy. Read More

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http://dx.doi.org/10.2478/prilozi-2018-0043DOI Listing
December 2018

[First experience of minimally invasive surgery in the upper digestive tract].

Rev Gastroenterol Peru 2018 Oct-Dec;38(4):340-344

Departamento de Cirugía Gastrointestinal y Endoscopia Digestiva, Instituto Nacional de Cancerología, Universidad Militar Nueva Granada. Bogotá, Colombia; Profesor Asistente de Cirugía, Facultad de Medicina, Universidad Nacional. Bogotá, Colombia.

Background: Upper gastrointestinal cancer is responsible of important numbers deaths worldwide and is widely associated with lifestyle and genetic factors. Minimally invasive surgery treatment is still controversial wit difficult learning curves, longer operative times but clear advantages in bleeding, postoperative pain, return to activities and less complications associated with de incision.

Objective: Describe our first experience in minimally invasive surgery of the upper alimentary tract for cancer at the Instituto Nacional de Cancerología. Read More

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March 2019
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Pathology of wild Norway rats in Vancouver, Canada.

J Vet Diagn Invest 2019 Mar;31(2):184-199

Department of Pathobiology, Ontario Veterinary College, University of Guelph and Canadian Wildlife Health Cooperative (CWHC; Ontario-Nunavut Region), Guelph, ON, Canada (Rothenburger, Nemeth, Jardine).

To achieve a contemporary understanding of the common and rare lesions that affect wild, urban Norway rats ( Rattus norvegicus), we conducted a detailed pathology analysis of 672 rats from Vancouver, British Columbia, Canada. Grossly evident lesions, such as wounds, abscesses, and neoplasms, were present in 71 of 672 rats (11%) and tended to be severe. The most common and significant lesions were infectious and inflammatory, most often affecting the respiratory tract and associated with bite wounds. Read More

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http://dx.doi.org/10.1177/1040638719833436DOI Listing
March 2019
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Diagnosis of chronic anaemia in gastrointestinal disorders: A guideline by the Italian Association of Hospital Gastroenterologists and Endoscopists (AIGO) and the Italian Society of Paediatric Gastroenterology Hepatology and Nutrition (SIGENP).

Dig Liver Dis 2019 Feb 11. Epub 2019 Feb 11.

Oncological Gastroenterology Division, Centro di Riferimento Oncologico (CRO) IRCCS, Aviano.

Anaemia is a common pathologic condition, present in almost 5% of the adult population. Iron deficiency is the most common cause; other mechanisms can be involved, making anaemia a multi-factorial disorder in most cases. Anaemia being a frequent manifestation in the diseases of the gastrointestinal tract, patients are often referred to gastroenterologists. Read More

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http://dx.doi.org/10.1016/j.dld.2019.01.022DOI Listing
February 2019
1 Read

[IgG4 related hypertrophic gastropathy. Report of one case].

Rev Med Chil 2019 ;147(1):119-124

Servicio de Anatomía Patológica, Clínica Dávila, Santiago, Chile.

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http://dx.doi.org/10.4067/S0034-98872019000100119DOI Listing

Characterizing the microbiota in gastrointestinal tract segments of Rhabdophis subminiatus: Dynamic changes and functional predictions.

Microbiologyopen 2019 Mar 7:e789. Epub 2019 Mar 7.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu, China.

The gut microbiota helps the host to absorb nutrients and generate immune responses that can affect host behavior, development, reproduction, and overall health. However, in most of the previous studies, microbiota was sampled mainly using feces and intestinal contents from mammals but not from wild reptiles. Here, we described the bacterial profile from five different gastrointestinal tract (GIT) segments (esophagus, stomach, small intestine, large intestine, and cloaca) of three wild Rhabdophis subminiatus using 16S rRNA V4 hypervariable amplicon sequencing. Read More

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http://dx.doi.org/10.1002/mbo3.789DOI Listing

Paratracheal force, cricoid pressure and obstetric anaesthesia.

Anaesthesia 2019 04;74(4):547

Northwick Park Hospital, London, UK.

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http://dx.doi.org/10.1111/anae.14620DOI Listing

Ampullary Cancer.

Surg Clin North Am 2019 Apr 10;99(2):357-367. Epub 2019 Feb 10.

Department of Surgery, University of Alabama at Birmingham, 1808 7th Avenue South, BDB 607 Birmingham, AL 35233-3411, USA. Electronic address:

Compared with other periampullary tumors, cancers of the ampulla of Vater are rare. These tumors tend to present earlier than their pancreatic and distal bile duct brethren. In addition to the hypothesis that they are also less biologically aggressive, ampullary cancers tend to have better survival than other types of periampullary cancers. Read More

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http://dx.doi.org/10.1016/j.suc.2018.12.001DOI Listing
April 2019
1 Read

Sociedade Portuguesa de Cuidados Intensivos guidelines for stress ulcer prophylaxis in the intensive care unit.

Rev Bras Ter Intensiva 2019 Feb 28. Epub 2019 Feb 28.

Sociedade Portuguesa de Cuidados Intensivos - Lisboa, Portugal.

Critically ill patients are at risk of developing stress ulcers in the upper digestive tract. Agents that suppress gastric acid are commonly prescribed to reduce the incidence of clinically important stress ulcer-related gastrointestinal bleeding. However, the indiscriminate use of stress ulcer prophylaxis in all patients admitted to the intensive care unit is not warranted and can have potential adverse clinical effects and cost implications. Read More

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http://dx.doi.org/10.5935/0103-507X.20190002DOI Listing
February 2019
3 Reads

Prognostic Significance of Lymph Node Dissection Along the Upper-third-stomach in Patients With Lower-third Gastric Cancer.

Anticancer Res 2019 Mar;39(3):1485-1489

First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan

Background/aim: The extent of lymph node (LN) dissection is defined according to the type of gastrectomy regardless of tumor location in recent Japanese gastric cancer treatment guidelines. However, lymphatic flow from lower-third stomach mainly drain to supra- and infra-pyloric nodes, as well as to partially lesser curvature nodes along the descending limb of the left gastric artery. In this study, we evaluated the prognostic impact of LN dissection of right paracardial (No. Read More

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http://dx.doi.org/10.21873/anticanres.13266DOI Listing
March 2019
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Short- and Long-term Outcomes of Surgical Treatment for Remnant Gastric Cancer After Distal Gastrectomy.

Anticancer Res 2019 Mar;39(3):1411-1415

Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background/aim: Remnant gastric cancer (RGC) after distal gastrectomy occurs in 1-2% of patients, while the biological features of RGC are unknown.

Patients And Methods: A total of 22 consecutive patients with RGC who underwent total gastrectomy were analyzed. Their disease history included either gastric cancer (n=16) or peptic ulcer (n=6). Read More

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http://dx.doi.org/10.21873/anticanres.13256DOI Listing
March 2019
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Retrospective analysis of endoscopic management of foreign bodies in the upper gastrointestinal tract of adults.

J Chin Med Assoc 2019 Feb;82(2):105-109

Division of Gastroenterology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, ROC.

Background: Foreign body impaction in the upper gastrointestinal (UGI) tract is considered an emergency worldwide. This article reports our experience in the endoscopic management of foreign bodies in the UGI tract of adults.

Methods: A retrospective chart review was conducted on adult patients (aged >18 years) who received endoscopic management of foreign bodies in the UGI tract at Shuang Ho Hospital between November 2008 and November 2016. Read More

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http://dx.doi.org/10.1097/JCMA.0000000000000010DOI Listing
February 2019
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Angioedema - Our Experience Focused On Socio-Demographic, Etiological and Clinical Characteristics of the Condition and Its Management.

Open Access Maced J Med Sci 2019 Feb 28;7(3):341-346. Epub 2019 Jan 28.

Medical University, Plovdiv, Bulgaria.

Background: Angioedema (AE) is acute oedema of the skin and mucous surfaces, involving the respiratory and gastrointestinal tracts. AE could be a life-threatening medical condition. Regardless of its growing clinical importance, many aspects of its aetiology and pathogenesis remain poorly understood. Read More

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http://dx.doi.org/10.3889/oamjms.2019.040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6390144PMC
February 2019
1 Read

Possible application of trefoil factor family peptides in gastroesophageal reflux and Barrett's esophagus.

Peptides 2019 Mar 1;115:27-31. Epub 2019 Mar 1.

Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland. Electronic address:

Gastroesophageal reflux disease (GERD) is a chronic disorder of the digestive tract characterised mainly by a heartburn. Being one of the most common gastrointestinal diseases, the prevalence of GERD reaches up to 25.9% in Europe. Read More

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http://dx.doi.org/10.1016/j.peptides.2019.02.007DOI Listing
March 2019
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International Consensus on Guiding Recommendations for Management of Patients with Nonsteroidal Antiinflammatory Drugs Induced Gastropathy-ICON-G.

Euroasian J Hepatogastroenterol 2018 Jul-Dec;8(2):148-160. Epub 2019 Feb 1.

Department of Emerging Markets, Dr Reddy's Laboratories Ltd, Hyderabad, Andhra Pradesh, India.

Introduction: Nonsteroidal anti-inflammatory drugs (NSAIDs), one of the most commonly used medications worldwide, are frequently associated with gastrointestinal adverse events. Primary care physicians often face the challenge of achieving adequate pain relief with NSAIDs, while keeping their adverse events to a minimum. This is especially true when long-term use of NSAIDs is required such as in patients with osteoarthritis and rheumatoid arthritis. Read More

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http://dx.doi.org/10.5005/jp-journals-10018-1281DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395481PMC
February 2019
10 Reads

Severity of manchineel fruit (Hippomane mancinella) poisoning: A retrospective case series of 97 patients from French Poison Control Centers.

Toxicon 2019 Apr 28;161:28-32. Epub 2019 Feb 28.

Centre Antipoison de Paris, hôpital Fernand-Widal; Fédération de toxicologie FeTox, hôpital Lariboisière/Fernand-Widal, AP-HP; Inserm UMRS 1144, Paris, France.

In this retrospective series of 97 cases of manchineel fruit ingestion reported to French Poison Control Centers between 2009 and 2017, we investigated cases of poisoning due to manchineel fruit (from the Hippomane mancinella tree). This fruit is known to be responsible for oropharyngeal and gastrointestinal tract lesions and possibly hypotension and bradycardia (previously attributed to the presence of physostigmine). The most commonly observed clinical signs were oropharyngeal pain, abdominal pain, diarrhea and oropharyngeal irritation. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.02.014DOI Listing

Results of histopathology, immunohistochemistry, and molecular clonality testing of small intestinal biopsy specimens from clinically healthy client-owned cats.

J Vet Intern Med 2019 Feb 28. Epub 2019 Feb 28.

Gastrointestinal Laboratory, Texas A&M University, College Station, Texas.

Background: Histopathology, immunohistochemistry, and molecular clonality testing are metrics frequently used to diagnose chronic enteropathy (CE) in cats. However, normal values for these metrics have been based mainly on samples from cats that were relatively young, specific pathogen-free, or both.

Objectives: To describe results of histopathology, immunohistochemistry, and clonality testing of endoscopically-derived biopsy specimens of the upper small intestinal tract from a cohort of clinically healthy client-owned cats. Read More

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http://dx.doi.org/10.1111/jvim.15455DOI Listing
February 2019

Gastroesophageal Reflux Disease in the Neonatal Intensive Care Unit Infant: Who Needs to Be Treated and What Approach Is Beneficial?

Pediatr Clin North Am 2019 04 1;66(2):461-473. Epub 2019 Feb 1.

Innovative Research Program in Neonatal Feeding Disorders; The Neonatal and Infant Feeding Disorders Program, Nationwide Children's Hospital, Columbus, OH, USA; Division of Neonatology, Department of Pediatrics, Center for Perinatal Research, WB 5211, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, 575 Children's Cross Roads, Columbus, OH 43215, USA; Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Center for Perinatal Research, WB 5211, The Research Institute at Nationwide Children's Hospital, The Ohio State University College of Medicine, 575 Children's Cross Roads, Columbus, OH 43215, USA. Electronic address:

Gastroesophageal reflux (GER) and GER disease (GERD) pertaining to infants in the neonatal intensive care unit (NICU) are reviewed, based on research in this specific population. The developmental biology of the gastroesophageal junction, physiology of GER, and pathophysiology of GERD in this setting are summarized, and risk factors for GER and GERD identified. The epidemiology, economic burden, and controversies surrounding GERD in NICU infants are addressed, and an approach to GER and GERD in these patients formulated. Read More

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http://dx.doi.org/10.1016/j.pcl.2018.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6400306PMC
April 2019
1 Read

Endoscopic injection sclerotherapy for pediatric bleeding esophageal varices complicated by gastric vein, main portal vein, splenic mesenteric junction, and splenic vein occlusion: a case report.

BMC Gastroenterol 2019 Feb 28;19(1):37. Epub 2019 Feb 28.

Liver Transplant Program, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.

Background: Endoscopic injection sclerotherapy (EIS) is a life-saving procedure for pediatric patients with bleeding gastric varices (GV) associated with advanced liver cirrhosis and severe portal hypertension. Because of the lack of an endoscopic banding ligation device for pediatric patients, EIS is usually performed for bleeding esophageal varices (EV) in infants with congenital biliary atresia.

Case Presentation: We present a case of a 15-month-old female infant with type I biliary atresia with jaundice (total serum bilirubin, 22. Read More

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http://dx.doi.org/10.1186/s12876-019-0955-7DOI Listing
February 2019
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Structural and biological properties of polysaccharides from lotus root.

Int J Biol Macromol 2019 Feb 25;130:454-461. Epub 2019 Feb 25.

College of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, PR China. Electronic address:

To investigate the structure, in vitro digestibility and activity of polysaccharides from lotus root, their main fractions named LRPs were isolated and purified by gel filtration chromatography. Structural analyses indicated that: LRPs were α‑(1 → 6)‑d‑heteroglucans mainly composed of Glc-(1→, →6)-Glc-(1→, →6)-Gal-(1→, →4,6)-Gal-(1→ and →3,6)-Glc-(1→ at a molar ratio of 1.00: 4. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.02.146DOI Listing
February 2019
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Ectopic papilla of Vater in duodenum bulb: A hospital-based study.

Medicine (Baltimore) 2019 Feb;98(8):e14642

Division of Gastroenterology, Department of Internal Medicine, Taichung Tzu-Chi Hospital, Taichung, Taiwan.

The major papilla of Vater can be ectopically present in the stomach, pyloric canal, duodenal bulb, and third or fourth portion of the duodenum. In this study, we determined the clinical significance of ectopic papilla of Vater by endoscopic retrograde cholangiopancreatogram (ERCP).A retrospective study was conducted by reviewing the medical records of 6133 patients receiving ERCP from 1988 to 2011. Read More

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http://dx.doi.org/10.1097/MD.0000000000014642DOI Listing
February 2019
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Unrecognized esophageal fish bone impaction with delayed presentation of acute spastic central chest pain: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14627

Division of Cardiology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, R.O.C.

Rationale: Esophageal chest pain is difficult to be identified, and the diagnosis requires a high index of clinical suspicion. Upon presentation, they are difficult to be differentiated from acute coronary syndrome (ACS) by symptomatology alone.

Patient Concerns: We report a 71-year-old woman with multiple risk factors for coronary heart disease who presented with acute central spastic chest pain and was diagnosed as ACS in emergency department. Read More

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http://dx.doi.org/10.1097/MD.0000000000014627DOI Listing
February 2019
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Sonographic diagnosis of perforation of the gastric antrum caused by a foreign body: A case report.

Medicine (Baltimore) 2019 Feb;98(8):e14586

Department of Ultrasound, Lanxi People's Hospital, Jinhua, Zhejiang, China.

Rationale: Ingestion of foreign bodies often occurs in clinical environments, especially in toddlers and aged patients. Although plain radiography and CT are widely used for the assessment of foreign bodies, sonography has an advantage in the diagnosis of some radiolucent foreign bodies, such as wood and bamboo materials.

Patient Concerns: An 80-year-old woman presented with a 4-day history of right upper quadrant abdominal persistent distended pain without radiation. Read More

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http://dx.doi.org/10.1097/MD.0000000000014586DOI Listing
February 2019

Fallback technique with circular stapler prevents anastomotic obstruction after esophagectomy: A case report of surgical approach.

Medicine (Baltimore) 2019 Feb;98(8):e13571

Department of Thoracic Surgery.

Rationale: While performing esophago-ileal anastomosis after esophagectomy with circular staplers, the mucosal folds of the ileum can complicate stapling and lead to obstruction, especially when the diameter of the circular stapler is equal or greater than that of the small bowel lumen.

Patient Concerns: A 53-year-old man, presented with complaints of difficulty in swallowing for 2 weeks. Fifteen years previously, he had undergone partial gastrectomy for gastric ulcers. Read More

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http://dx.doi.org/10.1097/MD.0000000000013571DOI Listing
February 2019
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Nutrient drink test: A promising new tool for irritable bowel syndrome diagnosis.

World J Gastroenterol 2019 Feb;25(7):837-847

Department of Digestive Diseases, Hospital Clinico San Carlos and Complutense University, Madrid 28040, Spain.

Background: Irritable bowel syndrome (IBS) is a highly prevalent condition. It is diagnosed on the basis of chronic symptoms after the clinical and/or investigative exclusion of organic diseases that can cause similar symptoms. There is no reproducible non-invasive test for the diagnosis of IBS, and this raises diagnostic uncertainty among physicians and hinders acceptance of the diagnosis by patients. Read More

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http://dx.doi.org/10.3748/wjg.v25.i7.837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385016PMC
February 2019
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Crohn's Disease Complicated with Extensive Thrombosis of Limbs and Mesenteric Arteries: A Case report and literature review.

Ann Vasc Surg 2019 Feb 22. Epub 2019 Feb 22.

Department of Hepatobiliary and Pancreatic Surgery, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao City 266003, Shandong Province, China.

Introduction: Crohn's disease (CD) is a chronic disease characterized by purulent inflammation involving any part of the gastrointestinal tract between the oral cavity and the anus. Although studies have reported various complications of CD, arterial thrombosis is extremely rare in these patients. We report a patient with CD presenting with extensive thrombosis of the extremities and mesenteric arteries. Read More

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http://dx.doi.org/10.1016/j.avsg.2018.12.079DOI Listing
February 2019
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Vulnerability of gastric and small intestinal mucosa to ulcerogenic action of indomethacin in C57/BL6/J mice and transient receptor potential channel vanilloid type 1 knockout mice.

J Physiol Pharmacol 2018 Dec 21;69(6). Epub 2019 Feb 21.

Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.

Capsaicin-sensitive sensory nerves are densely distributed in the gastrointestinal system and involved in maintenance of gastrointestinal mucosal integrity. capsaicin selectively stimulates nociceptive neurons and its action is mediated through the transient receptor potential channel vanilloid type 1 (TRPV1) receptor. Activation TRPV1 receptors that play a fundamental role in pain signaling, may also exert protective effects against gastrointestinal injury. Read More

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http://dx.doi.org/10.26402/jpp.2018.6.09DOI Listing
December 2018
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In vitro fermentation of copra meal hydrolysate by human fecal microbiota.

3 Biotech 2019 Mar 19;9(3):93. Epub 2019 Feb 19.

1Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, Ladyaow, Chatuchak, Bangkok, 10900 Thailand.

Copra meal hydrolysate (CMH) is obtained by hydrolyzing defatted copra meal with β-mannanase from NT 6.7. In this study, we investigated the resistance of CMH to upper gastrointestinal tract digestion and the fecal fermentation profiles of CMH. Read More

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http://dx.doi.org/10.1007/s13205-019-1633-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385067PMC
March 2019
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