692 results match your criteria Undifferentiated Connective-Tissue Disease


Immune checkpoint inhibitors in treatment of soft-tissue sarcoma: A systematic review and meta-analysis.

Eur J Cancer 2021 Jun 6;152:165-182. Epub 2021 Jun 6.

Department of Medical Oncology, Ghent University Hospital, Ghent, Belgium; Cancer Research Institute Ghent, Ghent University, Ghent, Belgium.

Background: Soft-tissue sarcomas (STSs) are rare malignancies, accounting for approximately 1% of adult cancer. Metastatic disease carries a poor prognosis, and various efforts have been made to improve the prognosis of advanced STS, to date with little success. Immune checkpoint inhibitors (ICPIs) have substantially improved prognosis for many cancer types. Read More

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Pregnancy Outcomes in Undifferentiated Connective Tissue Disease Compared to Systemic Lupus Erythematosus: A Single Academic Center's Experience.

Arthritis Care Res (Hoboken) 2021 May 10. Epub 2021 May 10.

Duke University Medical Center, Durham, United States.

Objective: Systemic lupus erythematosus (SLE) patients have more pregnancy complications than healthy patients. Data regarding pregnancy outcomes in women with undifferentiated connective tissue disease (UCTD) are more limited, and existing studies are concentrated in Italy and predominantly in patients with a new diagnosis. We compared pregnancy outcomes for UCTD and SLE patients with established disease. Read More

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Undifferentiated connective tissue disease presenting with optic neuritis and concomitant axial spondyloarthritis: A rare case report.

Turk J Phys Med Rehabil 2021 Mar 4;67(1):111-114. Epub 2021 Mar 4.

Department of Physical Medicine and Rehabilitation, University of Health Sciences, Ankara Training and Research Hospital, Ankara, Turkey.

Undifferentiated connective tissue disease (UCTD) represents a group of diseases which do not fulfill the criteria of rheumatologic diseases or may be considered as an early stage of any of these diseases. Axial spondyloarthritis (axSpA) is a disease accompanied by symptoms of inflammatory low back pain and peripheral symptoms, with more spine and sacroiliac joint involvement. In this report, we, for the first time, present a case of UCTD presenting with axSpA in whom the initial finding was optic neuritis, which is rarely seen in UCTD. Read More

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Cosmetic Syndrome Correction with Calcium Hydroxylapatite-Based Filler in Patients with Connective Tissue Dysplasia.

Dermatol Res Pract 2021 14;2021:6673058. Epub 2021 Apr 14.

I. M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Undifferentiated connective tissue dysplasia is one of the most common diseases of nowadays, which does not fit into the group of hereditary syndromes. This condition is diagnosed in 20-50% of the population at any age. The study aimed to correct the facial soft tissues of patients with undifferentiated connective tissue dysplasia through the cosmetic procedure of calcium hydroxylapatite injection. Read More

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Role of Osteopontin as a Potential Biomarker of Pulmonary Arterial Hypertension in Patients with Systemic Sclerosis and Other Connective Tissue Diseases (CTDs).

Pharmaceuticals (Basel) 2021 Apr 21;14(5). Epub 2021 Apr 21.

Department of Translational Medicine, Università del Piemonte Orientale UPO, 28100 Novara, Italy.

Pulmonary arterial hypertension (PAH) is a severe complication of connective tissue diseases (CTD). Its early diagnosis is essential to start effective treatment. In the present paper, we aimed to evaluate the role of plasma osteopontin (OPN) as a candidate biomarker of PAH in a cohort of CTD patients. Read More

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Thrombotic Microangiopathy Associated with Macrophage Activation Syndrome: A Multinational Study of 23 Patients.

J Pediatr 2021 Apr 7. Epub 2021 Apr 7.

IRCCS Istituto Giannina Gaslini, Genoa, Italy; Università degli Studi di Genova, Genoa, Italy; Sechenov First Moscow State Medical University, Moscow, Russian Federation.

Objective: To describe the clinical characteristics, treatment, and outcomes of a multinational cohort of patients with macrophage activation syndrome (MAS) and thrombotic microangiopathy (TMA).

Study Design: International pediatric rheumatologists were asked to collect retrospectively the data of patients with the co-occurrence of MAS and TMA. Clinical and laboratory features of patients with systemic juvenile idiopathic arthritis (sJIA)-associated MAS and TMA were compared with those of an historical cohort of patients with sJIA and MAS. Read More

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Breastfeeding in women with rheumatic diseases.

Lupus Sci Med 2021 04;8(1)

Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA

Objective: Many rheumatologists and women with rheumatic disease worry that the disease or treatment will prevent breast feeding. International guidelines establish, however, that most antirheumatic medications are compatible with breast feeding. We sought to identify the frequency and predictors of desire to and actually breast feeding in women with rheumatic diseases. Read More

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Synovial tissue derived characteristics are included in a nomogram for the prediction of treatment response in naïve Rheumatoid Arthritis.

Arthritis Rheumatol 2021 Mar 22. Epub 2021 Mar 22.

Division of Rheumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Objectives: This study aims to apply the synovitis assessment in routine care of naïve Rheumatoid Arthritis (RA) and to develop a multiparametric nomogram for baseline diagnostic and treatment response prediction.

Methods: 1015 patients [545 RA, 167 Psoriatic Arthritis (PsA), 199 Undifferentiated Peripheral Inflammatory Arthritis (UPIA), 18 crystal arthritis, 26 connective tissue diseases and 60 osteoarthritis (OA)] undergoing ultrasound (US)-guided synovial tissue (ST) biopsy were enrolled (SYNGem) and stratified based on disease phase. The Krenn synovitis score(KSS) was assessed and integrated with disease characteristics and clinical outcome and a nomogram was created incorporating predictors of "DAS-Remission achievement at 6 months" in naïve RA treated with a treat to target strategy. Read More

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[Undifferentiated connective tissue disease : what is it ?]

Authors:
Laure Brulhart

Rev Med Suisse 2021 Mar;17(729):498-500

Service de rhumatologie, Département de médecine, Réseau hospitalier neuchâtelois, 2300 La Chaux-de-Fonds.

The term undifferentiated connective tissue disease (UCTD) describe patients presenting with clinical and serological manifestations of systemic autoimmune diseases but not fulfilling the criteria for any defined connective tissue diseases. The challenge is to differentiate patient with a stable UCTD from patients that will evolve to a connective tissue disease with therapeutic and prognostic impact. This article describe UTCD concept, clinical presentation, evolution, and prognostic factors and patients management. Read More

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The Psychosocial Impact of Undifferentiated Connective Tissue Disease on Patient Health and Well-Being: A Qualitative Study.

J Clin Rheumatol 2021 Mar 5. Epub 2021 Mar 5.

From the Division of Rheumatology, Hospital for Special Surgery Department of Medicine, Weill Cornell Medicine Division of Rheumatology, Department of Social Work Programs Barbara Volcker Center for Women and Rheumatic Diseases, Hospital for Special Surgery, New York Department of Medicine, Montefiore Medical Center, Wakefield Campus, Albert Einstein College of Medicine, Bronx Research Division, Hospital for Special Surgery, New York, NY.

Despite increased awareness of the diagnosis and treatment of undifferentiated connective tissue disease (UCTD), there is little research on related psychosocial factors. This cross-sectional study qualitatively assesses the psychosocial impact of UCTD on patient health and well-being.

Methods: We identified 20 adult patients with UCTD enrolled in the UCTD and Overlap Registry at our tertiary care level hospital. Read More

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Anti-TIF-1γ Antibody Detection Using a Commercial Kit vs In-House Immunoblot: Usefulness in Clinical Practice.

Front Immunol 2020 1;11:625896. Epub 2021 Feb 1.

Internal Medicine Department, Hospital Vall d'Hebrón, Barcelona, Spain.

Objectives: Anti-TIF-1γ autoantibody detection is important for cancer screening in patients with dermatomyositis. The gold standard for anti-TIF-1γ detection, immunoprecipitation, is only available from a few specialized laboratories worldwide, so commercial ELISA/immunoblot tests have emerged in recent years. To analyze their usefulness in diagnosing cancer-associated dermatomyositis, we compared Euroimmun Euroline profile with our previously validated in-house immunoblot assay with human recombinant TIF-1γ. Read More

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February 2021

Nailfold Capillaroscopy in Systemic Diseases: Short Overview for Internal Medicine.

Rom J Intern Med 2021 Jan 29. Epub 2021 Jan 29.

Department of Rheumatology, Colentina Clinical Hospital, Bucharest, Romania.

Nailfold capillaroscopy (NFC) is now one of the main imaging tools in systemic sclerosis and imposed over time as an easy, non-invasive method for the nailfold microvascular bed assessment.In qualitative NFC normal pattern is characterized by homogeneous, parallel fashion arrangement of the last capillaries row as well as by capillaries with hairpin or non-specific variations like tortuous and/ or crossing shape.Nailfold capillaroscopy is strongly recommended for evaluation of all patients with Raynaud phenomenon. Read More

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January 2021

Intrauterine Infection: An Unusual Cause of Chorioamnionitis and Miscarriage in a Patient with Undifferentiated Connective Tissue Disease.

Diagnostics (Basel) 2021 Feb 4;11(2). Epub 2021 Feb 4.

Clinical Microbiology Laboratory, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, 42122 Reggio Emilia, Italy.

is a Gram-negative coccobacillus belonging to the family. In children less than 4 years old, invasive infection can induce septic arthritis and osteomyelitis, and more rarely endocarditis, meningitis, ocular infections, and pneumonia. In adults, it may be a cause of endocarditis. Read More

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February 2021

Efficacy and safety of mycophenolate mofetil in the treatment of rheumatic disease-related interstitial lung disease: a narrative review.

Drugs Context 2021 15;10. Epub 2021 Jan 15.

Chair and Rheumatology Unit, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.

Mycophenolate mofetil (MMF) is an antimetabolite with a potent inhibitory effect on proliferation of T and B lymphocytes used since the early 1990s for the prevention of acute allograft rejection after organ transplant. MMF is also widely used for the treatment of a variety of rheumatic diseases (RDs) and their pulmonary involvement. Interstitial lung disease (ILD) is a heterogeneous group of progressive fibrotic diseases of the lung, which is often secondary to RD and represents a major cause of morbidity and mortality. Read More

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January 2021

Malignancy in giant cell tumor of bone: analysis of an open-label phase 2 study of denosumab.

BMC Cancer 2021 Jan 22;21(1):89. Epub 2021 Jan 22.

Chemotherapy Unit, IRCCS Istituto Ortopedico Rizzoli, Department of Experimental, Diagnostic and Specialty Medicine (DIMES), Bologna University, 40136, Bologna, Italy.

Background: Giant cell tumor of bone (GCTB) is a rare osteoclastogenic stromal tumor. GCTB can rarely undergo malignant transformation. This post hoc analysis evaluated and classified malignancies in patients with GCTB who received denosumab. Read More

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January 2021

Porphyria cutanea tarda exacerbation as a paraneoplastic syndrome in vaginal cancer resolved with chemoradiation.

Gynecol Oncol Rep 2021 Feb 15;35:100682. Epub 2020 Dec 15.

Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, 401 N Broadway, Suite 1440, Baltimore, MD 21287, United States.

. The effects of therapeutic ionizing radiation in patients with PCT are not well understood. We report the case of a 55 year-old woman with a past medical history significant for kidney transplant with rejection and removal on hemodialysis, Stevens-Johnson syndrome, porphyria cutanea tarda, undifferentiated connective tissue disease probably systemic lupus, and hepatitis C, who underwent curative chemoradiation treatment for a recurrent vaginal squamous cell carcinoma. Read More

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February 2021

Interstitial Pneumonia with Autoimmune Features: Why Rheumatologist-Pulmonologist Collaboration Is Essential.

Biomedicines 2020 Dec 26;9(1). Epub 2020 Dec 26.

Respiratory Unit, San Gerardo Hospital, Department of Medicine and Surgery, University of Milan-Bicocca, 20900 Monza, Italy.

In 2015 the European Respiratory Society (ERS) and the American Thoracic Society (ATS) "Task Force on Undifferentiated Forms of Connective Tissue Disease-associated Interstitial Lung Disease" proposed classification criteria for a new research category defined as "Interstitial Pneumonia with Autoimmune Features" (IPAF), to uniformly define patients with interstitial lung disease (ILD) and features of autoimmunity, without a definite connective tissue disease. These classification criteria were based on a variable combination of features obtained from three domains: a clinical domain consisting of extra-thoracic features, a serologic domain with specific autoantibodies, and a morphologic domain with imaging patterns, histopathological findings, or multicompartment involvement. Features suggesting a systemic vasculitis were excluded. Read More

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December 2020

Connective tissue disease-related interstitial lung disease (CTD-ILD) and interstitial lung abnormality (ILA): Evolving concept of CT findings, pathology and management.

Eur J Radiol Open 2021 16;8:100311. Epub 2020 Dec 16.

Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine (SKKU-SOM), Seoul, Republic of Korea.

The connective tissue diseases (CTDs) demonstrating features of interstitial lung disease (ILD) include systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), progressive systemic sclerosis (PSS), dermatomyositis (DM) and polymyositis (PM), ankylosing spondylitis (AS), Sjogren's syndrome (SS), and mixed connective tissue disease (MCTD). In RA patients in particular, interstitial lung abnormality (ILA) (of varying degrees; severe vs. mild) is reported to occur in approximately 20-60 % of individuals and CT disease progression occurs in approximately 35-45 % of them. Read More

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December 2020

[Ultrastructural characteristics of the mechanisms of varicose transformation of veins of different localization].

Arkh Patol 2020 ;82(6):16-23

Research Institute of Eye Diseases, Moscow, Russia.

The contemporary interpretation of the pathogenesis of varicose vein transformation in young patients indicates the genetically determined pattern of this process. According to the diagnostic criteria proposed by T.I. Read More

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December 2020

A Case of Interstitial Pneumonia with Features of Autoimmunity.

R I Med J (2013) 2020 Dec 1;103(10):32-34. Epub 2020 Dec 1.

Director of Interstitial Lung Disease Program, Assistant Professor of Medicine, Division of Pulmonary and Critical Care Medicine, Alpert Medical School of Brown University, Providence, RI.

We present a case of a 61-year-old woman with several months of gradually worsening shortness of breath, requiring multiple hospitalizations with acute hypoxemic respiratory failure. She was initially treated for eosinophilic pneumonia presumed to be secondary to medications or rheumatoid lung without much improvement. Her subsequent chest CT showed honeycombing and diffuse ground-glass opacities, and she was found to have elevated rheumatoid factor (RF) and anti-CCP antibody titers without extrathoracic features of rheumatoid arthritis. Read More

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December 2020

Applying SLICC and ACR/EULAR systemic lupus erythematosus classification criteria in a cohort of patients with undifferentiated connective tissue disease.

Lupus 2021 Feb 30;30(2):280-284. Epub 2020 Nov 30.

Department of Internal Medicine, Division of Rheumatology and Immunology, 12284University of Nebraska Medical Center, Omaha, NE, USA.

Background/objective: New classification criteria for SLE have recently been developed. How these criteria affect the classification of patients with the SLE-mimicking condition UCTD is poorly understood. This study investigated the reclassification of UCTD patients using newly derived SLE criteria. Read More

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February 2021

Endothelial Progenitor Cell CD34 and CD133 Concentrations and Soluble HLA-G Concentrations During Pregnancy and in Cord Blood in Undifferentiated Connective Tissue Diseases Compared to Controls.

Reprod Sci 2021 May 25;28(5):1382-1389. Epub 2020 Nov 25.

Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Viale Golgi 19, 27100, Pavia, Italy.

The objective of this study is to evaluate endothelial progenitor cells (EPCs) CD34 CD133 and CD34 CD133 and soluble HLA-G (sHLA-G) concentrations among undifferentiated connective tissue disease (UCTD) subjects, compared to controls, during pregnancy and in cord blood. This is a case-control study including 29 controls and 29 UCTDs. CD34 CD133, CD34 CD133, and sHLA-G concentrations were detected in maternal plasma and in cord blood. Read More

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Diffused coronary arteritis in undifferentiated connective tissue disease identified with coronary atherosclerosis T1-weighted charac terization (CATCH).

Eur Heart J Cardiovasc Imaging 2021 May;22(6):e73

Department of Radiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1, Shuaifuyuan, Dongcheng District, Beijing, 100730, China.

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Classical Examples of the Concept of the ASIA Syndrome.

Biomolecules 2020 10 12;10(10). Epub 2020 Oct 12.

Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 5265601, Israel.

Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) was first introduced in 2011 by Shoenfeld et al. and encompasses a cluster of related immune mediated diseases, which develop among genetically prone individuals as a result of adjuvant agent exposure. Since the recognition of ASIA syndrome, more than 4400 documented cases have been reported so far, illustrated by heterogeneous clinical manifestations and severity. Read More

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October 2020

Clinico-demographic Profile of Undifferentiated Inflammatory Arthritis Patients.

J Nepal Health Res Counc 2020 Sep 8;18(2):288-292. Epub 2020 Sep 8.

Department of Rheumatology, National Centre for Rheumatic Diseases, Ratopul, Kathmandu, Nepal.

Background: Undifferentiated inflammatory arthritis is a group of inflammatory joint diseases that do not fulfil the classification criteria for any other rheumatic or connective tissue disorders. This study aims to describe the clinical, demographic and serological features of undifferentiated inflammatory arthritis cases presenting at a tertiary level rheumatology centre from Nepal.

Methods: A descriptive cross-sectional study conducted at National Centre for Rheumatic Diseases, Kathmandu, Nepal which represents a midterm analysis of the undifferentiated inflammatory arthritis registry maintained at the centre. Read More

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September 2020

Undifferentiated connective tissue disease at risk for systemic sclerosis: Which patients might be labeled prescleroderma?

Autoimmun Rev 2020 Nov 14;19(11):102659. Epub 2020 Sep 14.

Università degli Studi della Campania "Luigi Vanvitelli", Department of Precision Medicine, Section of Rheumatology, Italy; Schulich School of Medicine and Dentistry, University of Western Ontario, Division of Rheumatology, St. Joseph's Health Care, London, Ontario, Canada.

Undifferentiated Connective Tissue Disease at risk for Systemic Sclerosis (UCTD-risk-SSc), otherwise referred to as very early-early SSc (very early-early diagnosis of systemic sclerosis VEDOSS), is a condition characterized by Raynaud's phenomenon (RP) and either SSc serum marker autoantibodies or a capillaroscopic scleroderma pattern or both, but without satisfying classification criteria for SSc neither features consistent with SSc sine scleroderma. Approximately half the UCTD-risk-SSc patients develop definite SSc over 5-10 years of follow-up. Identifying patients who will undergo such evolution is an unmet need. Read More

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November 2020

A three-arm, multicenter, open-label randomized controlled trial of hydroxychloroquine and low-dose prednisone to treat recurrent pregnancy loss in women with undifferentiated connective tissue diseases: protocol for the Immunosuppressant regimens for LIving FEtuses (ILIFE) trial.

Trials 2020 Sep 9;21(1):771. Epub 2020 Sep 9.

Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, 145 Middle Shandong Road, Shanghai, 200001, China.

Background: Undifferentiated connective tissue disease (UCTD) is known to induce adverse pregnancy outcomes and even recurrent spontaneous abortion (RSA) by placental vascular damage and inflammation activation. Anticoagulation can prevent pregnancy morbidities. However, it is unknown whether the addition of immune suppressants to anticoagulation can prevent spontaneous pregnancy loss in UCTD patients. Read More

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September 2020

COVID-19 and rheumatic autoimmune systemic diseases: report of a large Italian patients series.

Clin Rheumatol 2020 Nov 27;39(11):3195-3204. Epub 2020 Aug 27.

Department of Clinical and Experimental Medicine, Immuno-Endocrine Section of Internal Medicine, Laboratory of Primary Human Cells, School of Medicine, University of Pisa, Via Savi, 10, I-56126, Pisa, Italy.

Introduction: Covid-19 infection poses a serious challenge for immune-compromised patients with inflammatory autoimmune systemic diseases. We investigated the clinical-epidemiological findings of 1641 autoimmune systemic disease Italian patients during the Covid-19 pandemic.

Method: This observational multicenter study included 1641 unselected patients with autoimmune systemic diseases from three Italian geographical areas with different prevalence of Covid-19 [high in north (Emilia Romagna), medium in central (Tuscany), and low in south (Calabria)] by means of telephone 6-week survey. Read More

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November 2020

Necessity of brain imaging in COVID-19 infected patients presenting with acute neurological deficits.

Interdiscip Neurosurg 2020 Dec 13;22:100883. Epub 2020 Aug 13.

Department of Neurosurgery, University of New Mexico School of Medicine, Albuquerque, NM, United States.

Background: Patients undergoing cardiopulmonary stabilization in the intensive care unit for novel coronavirus (COVID-19) are often sedated, placing timely assessment of a neurological decline at risk.

Case Description: Here, we present two cases of COVID-19 infected young patients transferred to our facility in a cardio-pulmonary crisis, with a poor neurological exam. While there was significant delay in obtaining brain imaging in the first patient, the second patient had timely recognition of her ischemic infarct, underwent emergent surgery, and is now doing well. Read More

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December 2020