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Clin Chem Lab Med 2022 Jun 24. Epub 2022 Jun 24.

Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy.

Objectives: Coronavirus disease (COVID-19) can present with various symptoms and can involve multiple organs. Women infected during pregnancy have a higher incidence of obstetrical complications and infants born to "positive" mothers may get the infection with different manifestations. Presepsin seems to be a promising sepsis biomarker in adults and neonates. Read More

Medicina (Kaunas) 2022 May 25;58(6). Epub 2022 May 25.

Institute for Maternal and Child Health IRCCS "Burlo Garofolo", 34137 Trieste, Italy.

True knots of the umbilical cord (UC) are a rare occurrence and are reported in 0.4-1.2% of deliveries. Read More

Int J Mol Sci 2022 Jun 13;23(12). Epub 2022 Jun 13.

Department of Pediatrics, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul 06351, Korea.

We attempted to determine whether intratracheal (IT) transplantation of mesenchymal stem cells (MSCs) could simultaneously attenuate hyperoxia-induced lung injuries and microbial dysbiosis of the lungs, brain, and gut in newborn rats. Newborn rats were exposed to hyperoxia (90% oxygen) for 14 days. Human umbilical cord blood-derived MSCs (5 × 10) were transplanted via the IT route on postnatal day (P) five. Read More

Pediatr Res 2022 Jun 22. Epub 2022 Jun 22.

Gynecology Research Unit, Hannover Medical School, Carl-Neuberg-Strasse 1, D-30625, Hannover, Germany.

Background: Successful pregnancies are nowadays possible after kidney transplantation but are associated with a higher incidence of maternal and fetal complications. Immunosuppressive therapy causes cardiovascular side effects but must be maintained during pregnancy. Little is known about the consequences of maternal kidney transplantation on offspring's endothelial health. Read More

Int J Endocrinol 2022 11;2022:9218113. Epub 2022 Jun 11.

Nanjing Maternity and Child Health Care Institute, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China.

Background: Impaired glucose metabolism and insulin sensitivity have been linked to the pathogenesis of gestational diabetes mellitus (GDM). Exosomes secreted by the umbilical cord mesenchymal stromal cells (UMSCs) and circular RNAs (circRNAs) derived from exosomes have been shown to be associated with the progression of GDM-related complications.

Methods: UMSCs were isolated from umbilical cords and identified through flow cytometry. Read More

Stem Cell Res Ther 2022 Jun 17;13(1):258. Epub 2022 Jun 17.

School of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

Background: Endothelial damage is an initial step of macro- and micro-vasculature dysfunctions in diabetic patients, accounting for a high incidence of diabetic vascular complications, such as atherosclerosis, nephropathy, retinopathy, and neuropathy. However, clinic lacks effective therapeutics targeting diabetic vascular complications. In field of regenerative medicine, mesenchymal stem cells, such as human umbilical cord-derived MSCs (hucMSCs), have great potential in treating tissue damage. Read More

J Orthop Surg Res 2022 Jun 11;17(1):307. Epub 2022 Jun 11.

Future Biologics, Lawrenceville, GA, 30043, USA.

Background: Musculoskeletal ailments impact the lives of millions of people, and at times necessitate surgery followed by physiotherapy, drug treatments, or immobilization. Regenerative musculoskeletal medicine has undergone enormous progress over the last few decades. Sources of tissues used for regenerative medicine purposes can be grouped into autologous or allogenic. Read More

J Obstet Gynaecol 2022 Jun 9:1-9. Epub 2022 Jun 9.

Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.

In this retrospective study, we analysed clinical and demographic data from the medical records of 31 pregnant women with coronavirus disease 2019 (COVID-19) who were treated at our hospital between April 2020 and April 2021. The most common symptom was a fever; ∼10% of patients were asymptomatic. One patient with rapidly worsening pneumonia needed a Caesarean Section at 30 weeks and was admitted for intensive care. Read More

Zhonghua Fu Chan Ke Za Zhi 2022 May;57(5):325-331

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, Beijing 100730, China.

To investigate the value of proteinuria in evaluating the severity of pre-eclampsia (PE) and assessing the maternal and neonatal outcomes of PE. The clinical records of 265 pregnant women who were diagnosed with PE at Peking Union Medical College Hospital from January 2011 to June 2021 were retrospectively analyzed. According to 24-hour urine protein (24-hUPro) results, pregnant women were divided into two groups: the non-proteinuric group (24-hUPro<0. Read More

Zhongguo Dang Dai Er Ke Za Zhi 2022 May;24(5):492-499

School of Nursing, Nanjing Medical University, Nanjing 211166, China.

Objectives: To study the influence of umbilical cord milking versus delayed cord clamping on the early prognosis of preterm infants with a gestational age of <34 weeks.

Methods: PubMed, Web of Science, Embase, the Cochrane Library, CINAHL, China National Knowledge Infrastructure, Wanfang Data, Weipu Database, and SinoMed were searched for randomized controlled trials on umbilical cord milking versus delayed cord clamping in preterm infants with a gestational age of <34 weeks published up to November 2021. According to the inclusion and exclusion criteria, two researchers independently performed literature screening, quality evaluation, and data extraction. Read More

Infect Dis Clin North Am 2022 Jun 31;36(2):423-433. Epub 2022 Jan 31.

Emory University School of Medicine, Department of Gynecology and Obstetrics, Woodruff Memorial Research Building, 101 Woodruff Circle, Suite 4208, Atlanta, GA 30322, USA.

Pregnancy seems to be a risk factor for severe disease with COVID-19. Although SARS-CoV-2 intrauterine transmission seems to be rare, most studies show COVID-19 during pregnancy increases the risk for pregnancy complications, with higher risk among those with severe disease compared with those mildly affected. Studies suggest that COVID-19 vaccination during pregnancy is safe and effective. Read More

Medicine (Baltimore) 2022 May 20;101(20):e29187. Epub 2022 May 20.

Department of Surgery, Chungbuk National University Hospital, Chungbuk National University College of Medicine, Cheongju, Korea.

Rationale: A patent urachus is a rare congenital anomaly that atypically presents as an umbilical cord cyst or large umbilical cord. Here we describe a case of a giant umbilical cord cyst in a newborn diagnosed as a patent urachus.

Patient Concerns: A male infant with a birth weight of 3260 g was transferred because of an antenatally diagnosed giant umbilical cord cyst accompanied by yellowish discharge and granulation in the umbilical cord after birth. Read More

Clin Epigenetics 2022 05 23;14(1):69. Epub 2022 May 23.

Department of Obstetrics and Gynecology, Hangzhou Women's Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, Zhejiang, People's Republic of China.

Background: Gestational diabetes mellitus (GDM) is a common pregnancy-specific disease and is growing at an alarming rate worldwide, which can negatively affect the health of pregnant women and fetuses. However, most studies are limited to one tissue, placenta or umbilical cord blood, usually with one omics assay. It is thus difficult to systematically reveal the molecular mechanism of GDM and the key influencing factors on pregnant women and offspring. Read More

Gynecol Obstet Invest 2022 23;87(2):141-149. Epub 2022 May 23.

Department of Obstetrics and Gynecology, Qinghai Red-Cross Hospital, Xining, China.

Objectives: Fetal macrosomia and its associated complications are the most frequent and serious morbidities for infants associated with gestational diabetes mellitus (GDM). In this study, we aimed to determine the expression of circulating circRNAs in humans, which may be promising biomarkers for the diagnosis of GDM or predicting the macrosomia in GDM patients.

Design: A multi-stage validation and risk score formula analysis was applied for validation. Read More

Taiwan J Obstet Gynecol 2022 May;61(3):489-493

Department of Maternal Fetal Medicine, Osaka Women's and Children's Hospital, Osaka, Japan.

Objective: To investigate the incidence of umbilical cord prolapse (UCP) and its influence on infant prognosis in pregnant women with preterm premature rupture of membranes (PPROM).

Materials And Methods: We conducted a retrospective cohort study in a single tertiary perinatal center between 2009 and 2017. Singleton pregnancies with PPROM that occurred between 22 and 33 weeks of gestation were included. Read More

Am J Obstet Gynecol 2022 May 14. Epub 2022 May 14.

Chinese PLA General Hospital, Medical School of Chinese PLA, Beijing, China; Department of Obstetrics and Gynaecology, Seventh Medical Center, Chinese PLA General Hospital, Beijing, China. Electronic address:

Background: There are limited data to guide the duration and dose of oxygen supplementation for pregnant women undergoing labor.

Objective: To assess the effect of maternal long-duration high-concentration oxygen administration during labor on umbilical cord venous partial pressure of oxygen.

Study Design: This randomized clinical trial was conducted between January and October of 2021 in the obstetrics wards of 3 tertiary teaching hospitals in Beijing, China. Read More

J Zhejiang Univ Sci B 2022 May;23(5):423-431

Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, China.

As a group of nonspecific inflammatory diseases affecting the intestine, inflammatory bowel disease (IBD) exhibits the characteristics of chronic recurring inflammation, and was proven to be increasing in incidence (Kaplan, 2015). IBD induced by genetic background, environmental changes, immune functions, microbial composition, and toxin exposures (Sasson et al., 2021) primarily includes ulcerative colitis (UC) and Crohn's disease (CD) with complicated clinical symptoms featured by abdominal pain, diarrhea, and even blood in stools (Fan et al. Read More

J Pediatr 2022 05;244:e9

Department of Pediatric Research, University of Oslo, Oslo, Norway; Ann and Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

Gynecol Obstet Invest 2022 6;87(2):165-172. Epub 2022 May 6.

Department of Obstetrics, Gynecology & Reproductive Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Introduction: Studies indicate a very low rate of SARS-CoV-2 detection in the placenta or occasionally a low rate of vertical transmission in COVID-19 pregnancy. SARS-CoV-2 Delta variant has become a dominant strain over the world and possesses higher infectivity due to mutations in its spike receptor-binding motif.

Case Presentation: To determine whether SARS-CoV-2 Delta variant has increased potential for placenta infection and vertical transmission, we analyzed SARS-CoV-2 infection in the placenta, umbilical cord, and fetal membrane from a case where an unvaccinated mother and her neonate were COVID-19 positive. Read More

Sao Paulo Med J 2022 May-Jun;140(3):390-397

MD. Physician, Department of Pediatrics, School of Medicine, Düzce University, Düzce, Turkey.

Background: Reduced antioxidant defenses may reflect a poor protective response against oxidative stress and this may be implicated in progression of gestational diabetes mellitus (GDM). Oxidative stress induced by hyperglycemia plays a major role in micro and macrovascular complications, which imply endothelial dysfunction.

Objective: Our aim in this study was to investigate the association between GDM and oxidative stress markers measured in plasma, with regard to revealing changes to total antioxidant capacity (TAC) and total oxidant status (TOS) among mothers showing impairments in oral glucose tolerance tests (OGTTs). Read More

Comput Math Methods Med 2022 13;2022:8661324. Epub 2022 Apr 13.

Chengdu Institute of Computer Application, Chinese Academy of Sciences, Chengdu 610041, China.

Objective: To explore the application of machine learning algorithm in the prediction and evaluation of cesarean section, predicting the amount of blood transfusion during cesarean section and to analyze the risk factors of hypothermia during anesthesia recovery.

Methods: (1)Through the hospital electronic medical record of medical system, a total of 600 parturients who underwent cesarean section in our hospital from June 2019 to December 2020 were included. The maternal age, admission time, diagnosis, and other case data were recorded. Read More

Diagnostics (Basel) 2022 Apr 14;12(4). Epub 2022 Apr 14.

National Institute of Mother and Child Care Alessandrescu-Rusescu, 020395 Bucharest, Romania.

Twin pregnancy contributes to perinatal mortality, particularly monochorionic diamniotic twin pregnancy. Placental abnormalities are much more common in twin pregnancies than in singletons. In MCDA pregnancy, vascular anastomoses are always present and are accountable for severe complications such as Twin-to-Twin transfusion syndrome (TTTS). Read More

Diagnostics (Basel) 2022 Apr 1;12(4). Epub 2022 Apr 1.

Department of Pathology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Kuala Lumpur 56000, Malaysia.

Background: Chorioamnionitis complicates about 1-5% of deliveries at term and causes about one-third of stillbirths. CXC-chemokine receptor 1 (CXCR1) binds IL-8 with high affinity and regulates neutrophil recruitment. We aimed to determine the immunoexpression of CXCR1 in placentas with chorioamnionitis, and its association with adverse perinatal outcomes. Read More

Int J Womens Health 2022 14;14:555-563. Epub 2022 Apr 14.

Hanoi Medical University, Hanoi, Vietnam.

Objective: To evaluate the surgery outcomes of fetoscopic laser ablation (FLA) for selective umbilical cord in treating twin-twin transfusion syndrome (TTTS) with special conditions and neonatal outcomes post-operation.

Methods: A prospective study, 21 monochorionic diamniotic (MCDA) twins diagnosed with TTTS stage II-IV according to Quintero classification from 16 to 26 weeks of gestation, among that, 12 cases of TTTS stage II with selective intrauterine growth restriction (sIUGR), 6 cases of TTTS stage II with proximate cord insertions, 3 cases of TTTS stage IV underwent fetoscopic laser ablation for the selective fetal reduction at Hanoi Obstetrics and Gynecology Hospital from September 2019 to July 2021. Complications and surgical outcomes were noted. Read More

Cell Death Discov 2022 Apr 15;8(1):205. Epub 2022 Apr 15.

Department of Intervention, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110000, P.R. China.

Currently, surgical extraction is the main therapy for cholangiocarcinoma (CCA) patients, but it's highly susceptible to postsurgical complications and recurrence rate. Thus, we identified the suppressing roles of exosomal miR-15a-5p from umbilical cord mesenchymal stem cells (UCMSCs) in the EMT and metastasis of CCA. The microarray dataset GSE265566 was employed to determine the expression of CHEK1 in CCA tissues. Read More

Med Arch 2022 Feb;76(1):4-11

Pusat Unggulan Inovasi (PUI) Stem Cell, Universitas Sumatera Utara (USU), Medan, Indonesia.

Background: A Erectile dysfunction (ED) is one of the well-known comorbidities in males with diabetes mellitus (DM), whose pathogenesis might be induced by dysregulation of corpus cavernosum smooth muscle cells. UC-MSCs are multipotent cells that attract considerable interest due to immunoregulatory properties and might be a potential strategy to regulate and recover the functional cells and tissues, including tissue improvement in DMED.

Objective: This study aims to determine the efficacy of UC-MSCs in improving the erectile function of DMED rats through analyzing the expression of TGF-β, α-SMA, and collagen. Read More

Health Sci Rep 2022 Apr 5;5(3):e566. Epub 2022 Apr 5.

Department of Obstetrics and Gynaecology, Ospedale Degli Infermi, Biella University of Turin Turin Italy.

Background And Aims: Aetiopathogenesis of chorioangioma is already unknown. Among the risk factors, hypoxia, environmental and genetic factors are believed to induce the overexpression of angiogenic cytokines promoting vascular proliferation. We reported a case of prenatally diagnosed 67 mm-wide placental chorioangioma, which occurred at 32 weeks of gestational age, infarcted, and followed by the onset of a second infarcted chorioangioma at 35 weeks of gestational age. Read More

Curr Diabetes Rev 2022 Apr 11. Epub 2022 Apr 11.

Dr. D. Y. Patil Vidyapeeth, Pimpri, Pune, India.

Type 1 diabetes mellitus (T1DM), an autoimmune disease, involves destruction of pancreatic β cells. β cells maintains glucose homeostasis by identifying blood glucose and accordingly releasing insulin in order to maintain normal physiologic glucose levels. Human umbilical cord blood (hUCB) cells posture a lesser risk of viral contamination as there is low placental transmission during prenatal life. Read More

Geburtshilfe Frauenheilkd 2022 Apr 29;82(4):410-419. Epub 2021 Sep 29.

Universitätsklinik für Gynäkologie, Geburtshilfe und Gynäkologische Endokrinologie, Kepler Universitätsklinikum, Johannes Kepler Universität Linz, Linz, Austria.

According to current guidelines, inpatient management until birth is considered standard in pregnant women with preterm premature rupture of membranes (PPROM). With the increasing burden on obstetric departments and the growing importance of satisfaction and right to self-determination in pregnant women, outpatient management in PPROM is a possible alternative to inpatient monitoring. The most important criterion for this approach is to ensure the safety of both the mother and the child. Read More

J Neuroinflammation 2022 Apr 6;19(1):80. Epub 2022 Apr 6.

Department of Urology, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou, 510630, China.

Background: Neuroinflammation in spinal dorsal horn (SDH) plays an important role in the pathogenesis of interstitial cystitis/bladder pain syndrome (IC/BPS). Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) exert potent anti-inflammatory activities in the treatment of various diseases. This study aimed to determine the therapeutic effects of MSC-EVs on IC and furtherly investigate the potential mechanism to attenuate neuroinflammation. Read More