79,424 results match your criteria Umbilical Cord Complications


Extracellular FABP4 uptake by endothelial cells is dependent on cytokeratin 1 expression.

Biochim Biophys Acta Mol Cell Biol Lipids 2018 Dec 3. Epub 2018 Dec 3.

Lipids and Atherosclerosis Research Unit, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Universitat Rovira i Virgili, Reus, Spain. Electronic address:

Aims: The aim of this study is to determine the physical and functional interplay between fatty acid-binding protein 4 (FABP4) and its membrane receptor-like candidate protein, cytokeratin 1 (CK1), and to determine the effect of hindering CK1-mediated FABP4 cellular uptake on non-disturbed or metabolically stressed endothelial cells.

Methods: We monitored the direct interaction between FABP4 and CK1 using surface plasmon resonance, and the effects of blocking exogenous FABP4 (eFABP4) cellular uptake were determined by using specific siRNA to knock down the expression of CK1 in human umbilical vein endothelial cells (HUVECs). The expression and nuclear translocation of transcription factors involved in oxidative stress (NRF2) and inflammation (p65 subunit of NF-ĸB transcription factor) were determined by Western blotting analysis. Read More

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December 2018
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BIOINFORMATIC ANALYSIS OF DOSE- AND TIME-DEPENDENT miRNome RESPONSES.

Radiat Prot Dosimetry 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Biomedical Technologies, Italian National Agency for New Technologies, Energy and Sustainable Economic Development (ENEA), Rome, Italy.

The advent of new 'omics' techniques determined a massive boost in the measurement of the whole spectra of molecules within cells, favoring promising new radiobiological studies at low doses. The main aim of this work was to assess the radiation-induced perturbations of miRNA profiles and their temporal dynamics. Human Umbilical Vein Endothelial Cells were irradiated with low doses of γ-rays. Read More

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December 2018
2 Reads

A computational and experimental study to develop E-selectin targeted peptides for molecular imaging applications.

Future Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Aix Marseille Univ, CNRS, Cent Marseille, ISM2, Marseille, France.

Aim: E-selectin is overexpressed on angiogenic and inflamed endothelium. Molecules binding to E-selectin with high affinity and specificity enable its use as a molecular imaging biomarker.

Material & Methods: The interactions of four different peptides (i. Read More

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December 2018

Paracrine Factors Released by Osteoblasts Provide Strong Platelet Engraftment Properties.

Stem Cells 2018 Dec 5. Epub 2018 Dec 5.

Canadian Blood Services, Centre for Innovation, Ottawa, Ontario, Canada.

Ex vivo expansion of hematopoietic stem cells (HSC) and progenitors may one day overcome the slow platelet engraftment kinetics associated with umbilical cord blood (UCB) transplantation. Serum-free medium conditioned with osteoblasts (i.e. Read More

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December 2018
1 Read

Hsa-miRNA-29a protects against high glucose-induced damage in human umbilical vein endothelial cells.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.

Sustained exposure to high glucose (HG) results in dysfunction of vascular endothelial cells. Hence, diabetic patients often suffer from secondary vascular damages, such as vascular sclerosis and thrombogenesis, which may eventually cause cardiovascular problems. Thus, elucidating how HG results in vascular endothelial cell damage and finding an approach for prevention are important to prevent and treat vascular damages in diabetic patients. Read More

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December 2018

Shoulder dystocia: incidence, mechanisms, and management strategies.

Int J Womens Health 2018 9;10:723-732. Epub 2018 Nov 9.

Division of Maternal-Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba, Winnipeg, Canada,

Shoulder dystocia can lead to death or brain damage for the baby. Traction on the head can damage the brachial plexus. The diagnosis should be made when the mother cannot push the shoulders out with her own efforts with the next contraction after delivery of the head. Read More

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November 2018

The therapeutic effects of traditional Chinese medicine Fusu agent in LPS-induced acute lung injury model rats.

Drug Des Devel Ther 2018 13;12:3867-3878. Epub 2018 Nov 13.

College of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China,

Purpose: Acute lung injury (ALI) is a common and fatal oxidative stress in the lung, mainly induced by endothelial injury and capillary leakage. In our previous study, "Fusu agent", a traditional Chinese medicine, was found to exert preventive effect on endothelial damage in lipopoly-saccharide (LPS)-induced ALI model rats partially via inhibiting heparanase1 (HPA1) activation and inhibiting the inflammatory factors. However, it is still unknown whether Fusu agent exerts its therapeutic effect in LPS-induced ALI model rats and its potential mechanism. Read More

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November 2018

Histone deacetylase inhibition disturbs the balance between ACE and chymase expression in endothelial cells: a potential mechanism of chymase activation in preeclampsia.

Hypertens Res 2018 Dec 5. Epub 2018 Dec 5.

Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center-Shreveport, Shreveport, LA, USA.

Chymase is a major angiotensin-converting enzyme (ACE)-independent angiotensin convertase, and its expression is upregulated in the maternal vascular endothelium in preeclampsia, a hypertensive disorder in human pregnancy. Increased chymase-dependent angiotensin II generation has been reported in several cardiovascular diseases, including atherosclerosis and aneurysmal lesions. However, it remains unclear how chymase is activated. Read More

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December 2018

Extracellular Protein Fibulin-7 and Its C-Terminal Fragment Have In Vivo Antiangiogenic Activity.

Sci Rep 2018 Dec 5;8(1):17654. Epub 2018 Dec 5.

Molecular Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, 20892, USA.

Angiogenesis is crucial for tissue development and homeostasis; however, excessive angiogenesis can lead to diseases, including arthritis and cancer metastasis. Some antiangiogenic drugs are available, but side effects remain problematic. Thus, alternative angiogenesis inhibition strategies are needed. Read More

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December 2018

Tissue-specific Accumulation and Body Burden of Parabens and Their Metabolites in Small Cetaceans.

Environ Sci Technol 2018 Dec 5. Epub 2018 Dec 5.

Parabens have been of global concern due to their endocrine disrupting properties. However, few studies have reported tissue-specific distribution of parabens in wildlife. In this study, we measured parabens and their metabolites in organs and tissues (blubber, muscle, melon, stomach, kidney, liver, gonad, brain, uterus, and umbilical cord, total n=94) of common dolphins (Delphinus capensis) and finless porpoises (Neophocaena asiaeorientalis), to investigate tissue-specific accumulation and body burden. Read More

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December 2018

Annexin A1 May Induce Pancreatic Cancer Progression as a Key Player of Extracellular Vesicles Effects as Evidenced in the In Vitro MIA PaCa-2 Model System.

Int J Mol Sci 2018 Dec 4;19(12). Epub 2018 Dec 4.

Department of Pharmacy, University of Salerno, via Giovanni Paolo II 132, 84084 Fisciano, Italy.

Pancreatic Cancer (PC) is one of the most aggressive malignancies worldwide. As annexin A1 (ANXA1) is implicated in the establishment of tumour metastasis, the role of the protein in PC progression as a component of extracellular vesicles (EVs) has been investigated. EVs were isolated from wild type (WT) and ANXA1 knock-out (KO) PC cells and then characterised by multiple approaches including Western blotting, Field Emission-Scanning Electron Microscopy, and Dynamic Light Scattering. Read More

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December 2018
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Spontaneous umbilical cord hematoma as a clinical and forensic medical problem in case of suspected obstetrician's medical malpractice.

Ginekol Pol 2018 ;89(11):642-643

Department of Forensic Medicine and Forensic Toxicology, School of Medicine in Katowice, Medical University of Silesia in Katowice, Poland.

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January 2018

RNA-sequencing analysis of umbilical cord plasma microRNAs from healthy newborns.

PLoS One 2018 3;13(12):e0207952. Epub 2018 Dec 3.

FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body fluids under normal conditions and their stability as well as their dysregulation in disease has led to ongoing interest in their diagnostic and prognostic potential. Circulating microRNAs may be valuable predictors of early-life complications such as birth asphyxia or neonatal seizures but there are relatively few data on microRNA content in plasma from healthy babies. Read More

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December 2018
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New Technique for Closure of Alveolar Cleft With Umbilical Cord Stem Cells.

J Craniofac Surg 2018 Nov 30. Epub 2018 Nov 30.

Department of Plastic and Reconstructive Surgery, Hospital de San José, Fundación Universitaria de Ciencias de la Salud, Servicio Cirugía Plástica Estética y Reconstructiva - Pabellón Arcadio Forero.

This article presents the case of a newly born female patient with a cleft of the primary palate (alveolar cleft), with an in utero diagnosis of the described cleft, from whom umbilical cord stem cells are obtained and cryopreserved. The patient is managed with nasoalveolar molding, and at 5 months of age, she is taken to surgery for cheiloplasty and gingivoperiostioplasty with umbilical cord stem cells. A radiographic and CT follow-up is carried out on the described cleft. Read More

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November 2018
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A guanidine-based synthetic compound suppresses angiogenesis via inhibition of acid ceramidase.

ACS Chem Biol 2018 Dec 3. Epub 2018 Dec 3.

Angiogenesis generates new blood vessels from pre-existing vessels. Tumours induce the formation of new blood vessels to ensure sufficient oxygen and nutrients for their growth. Normally, angiogenesis is induced by various pro-angiogenesis factors, including vascular endothelial growth factor (VEGF). Read More

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December 2018
2 Reads

Invasive Fungal Disease in Patients Undergoing Umbilical Cord Blood Transplantation after Myeloablative Conditioning Regimen.

Eur J Haematol 2018 Dec 1. Epub 2018 Dec 1.

Department of Hematology, Hospital Universitario y Politécnico La Fe, Valencia, Spain.

Objective: Characteristics and risk factors (RFs) of invasive fungal disease (IFD) have been little studied in the setting of umbilical cord blood transplantation (UCBT).

Method: We retrospectively included 205 single-unit myeloablative UCBT recipients with a median follow-up of 64 months.

Results: Fifty-six episodes of IFD were observed in 48 patients (23%) at a median time of 123 days after stem cell infusion. Read More

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December 2018

Primary free fibula reconstruction in life-threatening haemorrhage from high flow arteriovenous malformation of mandible.

Indian J Plast Surg 2018 May-Aug;51(2):222-230

Department of Plastic and Reconstructive Surgery, Nizams Institute of Medical Sciences, Hyderabad, Telangana, India.

Background: High flow arteriovenous malformation (AVM) of the mandible is rare, but it can present as a life-threatening emergency with severe intraoral bleeding for the first time. The gold standard of treatment for an AVM of the mandible is selective embolisation combined with resection and subsequent reconstructions. With the advent of advanced multidisciplinary techniques aimed at definitive therapy, surgical resection and primary reconstruction can provide an ideal anatomical and functional cure. Read More

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December 2018

Notoginsenoside R1 Protects HUVEC Against Oxidized Low Density Lipoprotein (Ox-LDL)-Induced Atherogenic Response via Down-Regulating miR-132.

Cell Physiol Biochem 2018 Nov 30;51(4):1739-1750. Epub 2018 Nov 30.

Background/aims: Radix notoginseng is a well-known traditional Chinese herbal medicine, has extensively pharmacological activities in cardiovascular system. Notoginsenoside R1 (NGR1) is one main active ingredient of Radix notoginseng. The purpose of this study was to evaluate the functional effects of NGR1 on atherosclerosis (AS). Read More

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November 2018

Umbilical cerebrospinal fluid fistula: Report and a review.

Neurol India 2018 Nov-Dec;66(6):1831-1833

Department of Neurosurgery, RIMS, Ranchi, Jharkhand, India.

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December 2018

Impact of central line bundle for prevention of umbilical catheter-related bloodstream infections in a neonatal intensive care unit: A pre-post intervention study.

Am J Infect Control 2018 Nov 27. Epub 2018 Nov 27.

Division of Pediatric Infectious Disease, Dr. Behçet Uz Child Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.

Background: Central line-associated bloodstream infection is the most common infection associated with health care in preterm infants. The purpose of this 18-month cross-sectional study was to evaluate the effectiveness of bundle applications in the prevention of umbilical venous catheter (UVC)-associated bloodstream infections.

Methods: This study included patients in whom UVCs were inserted and who were diagnosed with central line-associated bloodstream infection between July 1, 2016, and December 31, 2017, according to the Centers for Disease Control and Prevention criteria. Read More

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November 2018

[Efficacy Analysis of Unrelated Umbilical Cord Blood Transplantation for the Treatment of Wiskott-Aldrich Syndrome].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1816-1821

Department of Hematology,Zhongda Hospital,Southeast University,Nanjing 210009,Jiangsu Province, China.

Objective: To explore the clinical efficacy and safety of unrelated umbilical cord blood transplantation (UCBT) for the treatment of Wiskott-Aldrich syndrome(WAS).

Methods: Five pediatric patients with WAS received single UCBT were retrospectively analyzed. The median age of these male patients was 268 days (range, 3 days -695 days). Read More

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December 2018

[Effect of TGF-β1 and IL-10 on the Immunoregulatory Function of Extracellular Vesicles Derived from Mesenchymal Stem Cells].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1785-1792

Department of Hematology, Air Force General Hospital, Beijing 100142,China,E-mail:

Objective: To investigate the effect of immune regulatory molecules TGF-β1 and IL-10 on the immunoregulatory activities of extracellular vesicles(EV) secreted from mesenchymal stem cells (MSCs).

Methods: MSC were isolated from human umbilical cord and expanded, then were treated with TGF-β1 and IL-10 for 72h, and MSC-EVs in supernatants were isolated. The total protein content of all samples was determined by BCA methed. Read More

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December 2018

Newborn colonization and antibiotic susceptibility patterns of Streptococcus agalactiae at the University of Gondar Referral Hospital, Northwest Ethiopia.

BMC Pediatr 2018 Nov 30;18(1):378. Epub 2018 Nov 30.

Department of Medical Microbiology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, P. O. Box 196, Gondar, Ethiopia.

Background: Group B Streptococcus (GBS) that asymptomatically colonizing the recto-vaginal area of women is the most important cause of neonatal colonization. There is paucity of evidence about newborn colonization with GBS in Ethiopia. Thus, this study was aimed to determine the prevalence of newborn colonization with GBS, antibiotic susceptibility patterns of the isolates and associated risk factors at the University of Gondar Referral Hospital in Northwest Ethiopia METHODS: A prospective cross sectional study was conducted from December 2016 to November 2017. Read More

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November 2018

The Anti-Angiogenic Activity of a Cystatin F Homologue from the Buccal Glands of .

Mar Drugs 2018 Nov 29;16(12). Epub 2018 Nov 29.

School of Life Sciences, Liaoning Normal University, Dalian 116081, China.

Cystatins are a family of cysteine protease inhibitors which are associated with a variety of physiological and pathological processes in vivo. In the present study, the cDNA sequence of a cystatin F homologue called Lm-cystatin F was cloned from the buccal glands of . Although Lm-cystatin F shares a lower homology with cystatin superfamily members, it is also composed of a signal peptide and three highly conserved motifs, including the G in the N-terminal, QXVXG, as well as the PW in the C-terminal of the sequence. Read More

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November 2018
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[Effect of oxytocin on the levels of malondialdehyde, nitric oxide, and s100b protein in newborns].

Rev Peru Med Exp Salud Publica 2018 Jul-Sep;35(3):449-455

. Hospital III Yanahuara. Arequipa, Perú.

Objectives: To assess the effects of the administration of oxytocin during labor management on the levels of malondialdehyde (MDA), nitric oxide (NO), and S100B protein in newborns.

Materials And Methods: We selected 80 term pregnant women without obstetric and fetal pathology, forming two groups: pregnant women with normal delivery and pregnant women conducted with oxytocin. Blood was collected immediately after delivery from the umbilical cord vein to measure MDA, ON and from the artery for protein S100B. Read More

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December 2017

Assessment of oxidative damage and enzymatic antioxidant system activity on the umbilical cord blood and saliva from preterm newborns with risk factors for early-onset neonatal sepsis.

Rev Assoc Med Bras (1992) 2018 Oct;64(10):888-895

Dept. Of Neonatology - Municipal Hospital of Barueri/SP, Brasil.

Background: To determine the concentration of the Lipid Peroxidation Marker: Malondialdehyde (MDA), and Antioxidant Markers: Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Catalase (CAL) in umbilical cord blood and in unstimulated saliva in the first 24 and 48 hours of life in the PTNB of mothers with and without risk factors for early-onset neonatal sepsis.

Methods: Cross-sectional study with the signing of informed consent by the pregnant women and application of a standard questionnaire classifying the PTNB in Group 1 or 2.

Results: Twenty-one PTNB were studied. Read More

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October 2018
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Is It Safe for Trainees to Perform Single-Incision Pediatric Endosurgery Splenectomy?

J Laparoendosc Adv Surg Tech A 2018 Dec 5. Epub 2018 Dec 5.

3 Department of Anaesthesia, King Fahd Armed Forces Hospital , Jeddah, Saudi Arabia .

Introduction: Few centers worldwide have advanced single-incision pediatric endosurgery (SIPES) splenectomy. The safety and feasibility of SIPES performed by trainees were not assessed before. SIPES splenectomy is a demanding technique that needs high level of skills. Read More

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December 2018

The Effects of Platelet-Derived Growth Factor-BB on Bone Marrow Stromal Cell-Mediated Vascularized Bone Regeneration.

Stem Cells Int 2018 31;2018:3272098. Epub 2018 Oct 31.

Department of Prosthodontics, Ninth People's Hospital affiliated to Shanghai Jiao Tong University, School of Medicine, 639 Zhizaoju Road, Shanghai 200011, China.

Regenerative medicine for bone tissue mainly depends on efficient recruitment of endogenous or transplanted stem cells to guide bone regeneration. Platelet-derived growth factor (PDGF) is a functional factor that has been widely used in tissue regeneration and repair. However, the short half-life of PDGF limits its efficacy, and the mechanism by which PDGF regulates stem cell-based bone regeneration still needs to be elucidated. Read More

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October 2018

"We shall count it as a part of kyogero": acceptability and considerations for scale up of single dose chlorhexidine for umbilical cord care in Central Uganda.

BMC Pregnancy Childbirth 2018 Dec 4;18(1):476. Epub 2018 Dec 4.

CISMAC, Center for International Health, University of Bergen, Bergen, Norway.

Background: Cleansing the umbilical cord with chlorhexidine reduces neonatal morbidity and mortality, particularly in communities where newborn deaths and home births are common. As a result, the World Health Organization and national authorities are advocating the scale up of this intervention. In order for such a scale up to be effective, it has to be acceptable to the targeted population. Read More

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December 2018
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Stearoyl-Chitosan Coated Nanoparticles Obtained by Microemulsion Cold Dilution Technique.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

University of Turin, Dipartimento di Scienza e Tecnologia del Farmaco, via Giuria 9, Torino 10125, Italy.

Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability to open epithelial-tight-junctions. In this article, lipophilic stearoyl chitosan (ST-CS) was synthetized in order to anchor this polymer to lipid nanoparticles and prepare ST-CS-coated nanoparticles (ST-CS-NP) using the microemulsion cold dilution technique. Curcumin (CURC) was used as model drug. Read More

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November 2018

α-Melanocyte-Stimulating Hormone Attenuates Neovascularization by Inducing Nitric Oxide Deficiency via MC-Rs/PKA/NF-κB Signaling.

Int J Mol Sci 2018 Nov 30;19(12). Epub 2018 Nov 30.

Center for Stem Cell Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan.

α-melanocyte-stimulating hormone (α-MSH) has been characterized as a novel angiogenesis inhibitor. The homeostasis of nitric oxide (NO) plays an important role in neovascularization. However, it remains unclear whether α-MSH mitigates angiogenesis through modulation of NO and its signaling pathway. Read More

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November 2018

Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound-on-a-Chip Model.

Adv Healthc Mater 2018 Dec 4:e1801307. Epub 2018 Dec 4.

School of Chemical Biomolecular Engineering, University of Sydney, Sydney, 2006, Australia.

Considerable progress has been made in the field of microfluidics to develop complex systems for modeling human skin and dermal wound healing processes. While microfluidic models have attempted to integrate multiple cell types and/or 3D culture systems, to date they have lacked some elements needed to fully represent dermal wound healing. This paper describes a cost-effective, multicellular microfluidic system that mimics the paracrine component of early inflammation close to normal wound healing. Read More

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December 2018
5 Reads

Correlation of short-term variation and Doppler parameters with adverse perinatal outcome in low-risk fetuses at term.

Arch Gynecol Obstet 2018 Dec 3. Epub 2018 Dec 3.

Department of Obstetrics and Gynecology, Erlangen University Hospital, Universitätsstraße 21-23, 91054, Erlangen, Germany.

Objective: To evaluate the association of short-term variation (STV) and Doppler parameters with adverse perinatal outcome in low-risk fetuses at term.

Methods: This was a retrospective study of 1008 appropriate-for-gestational age (AGA) term fetuses. Doppler measurements [umbilical artery (UA), middle cerebral artery (MCA), and cerebroplacental ratio (CPR)] and computerized CTG (cCTG) with STV analysis were performed prior to active labor (≤ 4 cm cervical dilatation) within 72 h of delivery. Read More

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December 2018

Lateral sided trocar site hernia following laparoscopic hernia repair: results of a long-term follow-up.

Hernia 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, Dr. Lutfi Kirdar Kartal Research and Education Hospital, Semsi Denizer Street, Cevizli, Kartal, Istanbul, Turkey.

Purpose: Trocar site hernias (TSH) at the umbilical site following laparoscopic cholecystectomy forms the majority of the studies about TSH and there is a missing data in literature about lateral sided TSH. We aimed to evaluate the incidence and factors affecting lateral sided TSH occurrence following laparoscopic abdominal wall hernia repair (LAHR).

Methods: Patients who underwent LAHR between March 2013 and 2015 were included in the study. Read More

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December 2018
2 Reads

Synaptic Plasticity of Human Umbilical Cord Mesenchymal Stem Cell Differentiating into Neuron-like Cells In Vitro Induced by Edaravone.

Stem Cells Int 2018 28;2018:5304279. Epub 2018 Oct 28.

Department of Anesthesiology and Critical Care, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Objective: The human umbilical cord mesenchymal stem cells (hUMSCs) are characterized with the potential ability to differentiate to several types of cells. Edaravone has been demonstrated to prevent the hUMSCs from the oxidative damage, especially its ability in antioxidative stress. We hypothesized that Edaravone induces the hUMSCs into the neuron-like cells. Read More

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October 2018
1 Read

FPR1 mediates the tumorigenicity of human cervical cancer cells.

Cancer Manag Res 2018 16;10:5855-5865. Epub 2018 Nov 16.

Department of Obstetrics and Gynecology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China,

Purpose: The present study aimed to investigate the role of FPR1 and the downstream effectors such as NF-κB and IL-6/8 in the development of cervical cancer.

Patients And Methods: FPR1 protein expression was detected via immunohistochemical staining in tissue microarrays containing cervical cancer tissues from 185 patients. Following FPR1 silencing in SiHa cells using lentiviral siRNA delivery, biological characteristics and tumor formation were evaluated in vitro and in vivo, respectively. Read More

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November 2018
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miR-125a-5p suppresses colorectal cancer progression by targeting VEGFA.

Cancer Manag Res 2018 16;10:5839-5853. Epub 2018 Nov 16.

Department of Gastroenterology, The Second Affiliated Hospital of Nantong University, Nantong, Jiangsu, China,

Background: MiR-125a-5p has been reported to be involved in the development and progression of various cancers. However, the biological function and underlying mechanisms in colorectal cancer(CRC) still remain unclear. Here, we explored the potential biological roles of miR-125a-5p in CRC. Read More

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November 2018

National variation in opioid prescribing after pediatric umbilical hernia repair.

Surgery 2018 Nov 30. Epub 2018 Nov 30.

Department of Surgery, University of Wisconsin-Madison, WI.

Background: Pediatric umbilical hernia repair is a common procedure that requires minimal tissue disruption. We examined variation in opioid prescription fills after repair of uncomplicated umbilical hernias to characterize the types and doses of medication used and persistent postsurgical use.

Methods: Using the Truven Health Analytics MarketScan© Research Database for June 2012-September 2015, we identified pediatric patients undergoing umbilical hernia repair. Read More

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November 2018

Discovery of novel anti-angiogenesis agents. Part 10: Multi-target inhibitors of VEGFR-2, Tie-2 and EphB4 incorporated with 1,2,3-triazol.

Eur J Med Chem 2018 Nov 22;163:1-9. Epub 2018 Nov 22.

School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, China. Electronic address:

VEGFR-2, Tie-2, and EphB4 are essential for both angiogenesis and tumorigenesis. Herein, we developed a series of pyridines incorporated with 1,2,3-triazole as multi-target inhibitors based on the crystal structure alignment of the kinase domain of angiogenic RTKs. Biological results indicated that these multi-target inhibitors displayed considerable potential as novel anti-angiogenic agents. Read More

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November 2018

Transcriptional Activity of Human Endogenous Retroviruses in Response to Prenatal Exposure of Maternal Cigarette Smoking.

Am J Perinatol 2018 Nov 30. Epub 2018 Nov 30.

Department of Public Health and Pediatric Sciences, Citoimmunodiagnostics Laboratory, University of Turin, Medical School, Turin, Italy.

Objective:  Transcription of human endogenous retrovirus (HERV) elements is usually suppressed by epigenetic factors such as DNA methylation and heterochromatin silencing by histone modifications. There is an association between maternal smoking during pregnancy and DNA methylation levels in placental tissue and in DNA from cord blood.

Materials And Methods:  We assessed the transcriptional activity of HERV-H, HERV-K, and HERV-W in umbilical cord blood from 47 term babies unexposed to tobacco smoke in utero and 23 term babies exposed to tobacco smoke in utero. Read More

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November 2018

Imaging of liver fusion and vascular intra-hepatic shunts in omphalopagus conjoined twins: The role of a double CT study.

Clin Imaging 2018 Nov 22;54:25-30. Epub 2018 Nov 22.

Department of Radiology, Papa Giovanni XXIII Hospital, Piazza OMS 1, Bergamo, Italy.

Omphalopagus twins are joined ventrally in the umbilical region. In omphalopagus twins, liver's fusion is very frequent, being present in about 80% of cases. Two conjoined twins born in our Hospital were evaluated using plain x-rays, ultrasound (US), gastrointestinal xrays, Tc-99 hepatobiliary scintigraphy (SC) and contrast enhanced computed tomography (CT). Read More

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November 2018
3 Reads

A novel mechanism of Gamma-aminobutyric acid (GABA) protecting human umbilical vein endothelial cells (HUVECs) against HO-induced oxidative injury.

Comp Biochem Physiol C Toxicol Pharmacol 2018 Nov 27. Epub 2018 Nov 27.

Institute of Bast Fiber Crops, Chinese Academy of Agricultural Sciences, China; Center for Southern Economic Crops, Chinese Academy of Agricultural Sciences, China. Electronic address:

Vascular endothelial cell damage is related to many vascular diseases, including cardiovascular disease (CVD). Reactive oxygen species (ROS) play a vital role in the pathogenesis of many cardiovascular diseases. Herein, HO-induced human umbilical vein endothelial cell (HUVEC) injury model was used to explore the mechanisms involved in the pathogenesis of ROS-induced oxidative stress and cell dysfunction. Read More

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November 2018

Prognostic Performance of the Augmented Hematopoietic Cell Transplantation-Specific Comorbidity/Age Index in Recipients of Allogeneic Hematopoietic Stem Cell Transplantation from Alternative Graft Sources.

Biol Blood Marrow Transplant 2018 Nov 27. Epub 2018 Nov 27.

Clinical Research Division, Fred Hutchinson Cancer Research Center; Seattle, WA; Division of Medical Oncology, Department of Medicine, University of Washington School of Medicine; Seattle, WA. Electronic address:

The Hematopoietic Cell Transplantation-specific Comorbidity Index (HCT-CI) was developed and validated to weigh the burden of pretransplant comorbidities and estimate their impact on post-transplant risks of non-relapse mortality (NRM). Recently, the HCT-CI was augmented by the addition of both age and values of three markers namely, ferritin, albumin, and platelet count. The HCT-CI research so far has been almost exclusively limited to recipients of allogeneic HCT from human leucocyte antigen (HLA)-matched grafts. Read More

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November 2018

Overexpression of tissue factor induced atherothrombosis in apolipoprotein E-/- mice via both enhanced plaque thrombogenicity and plaque instability.

J Mol Cell Cardiol 2018 Nov 27. Epub 2018 Nov 27.

The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China. Electronic address:

The mechanisms leading to atherothrombosis from "vulnerable plaque" are more complex than initially proposed. We aimed to clarify whether plaque thrombogenicity is critical in atherothrombosis in mice. In a murine model of plaque destabilization, we enhanced plaque thrombogenicity by systemically overexpressing murine tissue factor (TF) by adenovirus-mediated gene transfer. Read More

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November 2018
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Long-Term Therapeutic Effect of Cell Therapy on Improvement in Erectile Function in a Rat Model with Pelvic Neurovascular Injury.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Wake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, 27101, USA.

Objective: To determine the long-term therapeutic effect among three types of human cell types on erectile function recovery in a rodent model of dual neurovascular injured erectile dysfunction (NVED).

Materials And Methods: A dual NVED model was established in athymic rats by crushing the bilateral cavernous nerves and ligations of the bilateral internal pudendal nerve-vessel bundles. At the time of defect creation, three different types of human cell populations (2. Read More

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November 2018

Prenatal and Early Postnatal Exposure to Total Mercury and Methylmercury from Low Maternal Fish Consumption.

Biol Trace Elem Res 2018 Nov 29. Epub 2018 Nov 29.

Department of Clinical and Experimental Pharmacotherapy, Faculty of Medicine, Slovak Medical University in Bratislava, Limbova 12, 833 03, Bratislava, Slovak Republic.

The aim of this study was to investigate the influence of low fish consumption on prenatal and early postnatal exposure to mercury species. The samples of umbilical cord blood and maternal milk as well as interviewer-administered questionnaires were collected from 142 Slovak mother-child pairs. The mean total mercury (THg) concentrations in cord blood and milk were 0. Read More

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November 2018

Umbilical Cord Milking: A Review.

Authors:
Anup C Katheria

Front Pediatr 2018 13;6:335. Epub 2018 Nov 13.

Sharp Mary Birch Hospital for Women & Newborns, San Diego, CA, United States.

This is a review of umbilical cord milking, a controversial technique where the umbilical cord is squeezed several times before it is clamped an cut. While not physiological or natural for newborns, the question lies as to whether it is useful in certain circumstances, namely the depressed newborn. Here we review the literature and discuss why it could be considered as an alternative for the current practice of delayed cord clamping. Read More

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November 2018

Treatment of multiple system atrophy - the past, present and future.

Am J Clin Exp Immunol 2018 5;7(5):88-94. Epub 2018 Oct 5.

Department of Neurology, Liaocheng People's Hospital, Liaocheng Clinical School, Taishan Medical University Liaocheng, PR China.

Multiple system atrophy is a sporadic progressive degenerative disease which is characterized by multiple central nervous systems involved. So far, there is no effective medicine to cure MSA. The main research direction of treatment includes immunization transplantation and cytotherapy. Read More

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October 2018

Pena-Shokeir syndrome: current management strategies and palliative care.

Appl Clin Genet 2018 25;11:111-120. Epub 2018 Oct 25.

Department of Biochemistry, Genetics and Microbiology, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa.

Pena-Shokeir syndrome (PSS) type 1, also known as fetal akinesia deformation sequence, is a rare genetic syndrome that almost always results in intrauterine or early neonatal death. It is characterized by markedly decreased fetal movements, intrauterine growth restriction, joint contractures, short umbilical cord, and features of pulmonary hypoplasia. Antenatal diagnosis can be difficult. Read More

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October 2018

The presumed MTH1-inhibitor TH588 sensitizes colorectal carcinoma cells to ionizing radiation in hypoxia.

BMC Cancer 2018 Nov 29;18(1):1190. Epub 2018 Nov 29.

Institut für Physiologie, Universität Duisburg-Essen, Hufelandstraße 55, D45122, Essen, Germany.

Background: The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondrial DNA. Therefore MTH1 was proposed to protect cancer cells from oxidative DNA lesions and subsequent cell death. We investigated whether the bona fide MTH1 inhibitor TH588 affects responses of cultured colorectal tumor cells to ionizing radiation (IR) in normoxia and in moderate or severe hypoxia. Read More

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November 2018
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