6,009 results match your criteria Umbilical Cord Complications


Preliminary research on the effects and mechanisms of umbilical cord‑derived mesenchymal stem cells in streptozotocin‑induced diabetic retinopathy.

Int J Mol Med 2020 Aug 1;46(2):849-858. Epub 2020 Jun 1.

Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.

Diabetic retinopathy (DR) is one of the most prevalent microvascular complications of diabetes, and a common cause of blindness in working‑age individuals. Mesenchymal stem cell (MSC) transplantation has been considered a promising intervention therapy for DR, wherein the differentiation of MSCs into nerve cells plays an essential role. However, research into the role of MSCs in DR treatment remains incomplete, and the mechanisms of retinal repair at the molecular level have yet to be clarified. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4623DOI Listing

MiR-101-containing extracellular vesicles bind to BRD4 and enhance proliferation and migration of trophoblasts in preeclampsia.

Stem Cell Res Ther 2020 Jun 11;11(1):231. Epub 2020 Jun 11.

Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, No. 600, Tianhe Road, Guangzhou, 516000, Guangdong Province, People's Republic of China.

Background: Preeclampsia (PE) is a frequently occurring pregnancy disorder in the placenta, which results in various maternal and fetal complications. The current study aims to evaluate the role of extracellular vesicles (EVs)-encapsulated microRNA (miR)-101 in biological processes of trophoblasts in PE and its underlying mechanism.

Methods: Human umbilical cord mesenchymal stem cell (HUCMSC) and HUCMSC-derived EVs were isolated and cultured, after which EV characterization was carried out using PKH67 staining. Read More

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http://dx.doi.org/10.1186/s13287-020-01720-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291671PMC

Incidence of Viral and Fungal Infectious Complications after utilization of alternative donor sources in hematopoietic cell transplantation (HCT).

Pharmacotherapy 2020 Jun 4. Epub 2020 Jun 4.

Janssen Biotech, Horsham, PA, USA.

Allogeneic hematopoietic cell transplantation (HCT) remains the only curable option for adult patients with hematologic malignancies. According to guidelines published by the American Society for Transplantation and Cellular Therapy, allogeneic HCT should be offered to all intermediate- and high-risk patients with acute leukemia. While matched-related donor (MRD) grafts continue to be the preferred stem cell source for allogeneic HCT, studies comparing MRD grafts to matched-unrelated donor (MUD) grafts showed comparable outcomes in patients with acute leukemia. Read More

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http://dx.doi.org/10.1002/phar.2433DOI Listing

A comparison of maternal and perinatal outcomes with vaginal delivery: indicated induction versus spontaneous labor.

J Matern Fetal Neonatal Med 2020 Jun 4:1-6. Epub 2020 Jun 4.

Department of Obstetrics and Gynecology, University of Mississippi Medical Center, Jackson, MS, USA.

To determine if there is a difference in the maternal and perinatal characteristics and outcomes of women undergoing a medically indicated labor induction and delivering vaginally compared to women in spontaneous labor delivering vaginally. This is a planned secondary analysis of previously published data with additional data collected for a case-control design. Maternal and perinatal characteristics and outcomes of women undergoing a medically indicated labor induction of labor and delivering vaginally were compared with the next woman who went into labor spontaneously and delivered vaginally. Read More

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http://dx.doi.org/10.1080/14767058.2020.1774545DOI Listing

The effect of mother's β-thalassemia minor on placental histology and neonatal outcomes.

J Matern Fetal Neonatal Med 2020 Jun 4:1-8. Epub 2020 Jun 4.

Maternal-Fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

β-thalassemia is a prevalent disease in Iran. The adverse effects of anemia on placental and neonatal outcomes have previously been shown. Women require additional iron during pregnancy and the anemia of women with β-thalassemia may adversely affect the neonatal outcome and increase placental abnormalities. Read More

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http://dx.doi.org/10.1080/14767058.2020.1774540DOI Listing

Role and effect of vein-transplanted human umbilical cord mesenchymal stem cells in the repair of diabetic foot ulcers in rats.

Acta Biochim Biophys Sin (Shanghai) 2020 Jun;52(6):620-630

Department of Interventional Radiology, Affiliated Hospital of Nantong University, Nantong 226001, China.

Diabetic foot ulcer (DFU) is one of diabetic complications, which is frequently present and tormented in diabetes mellitus. Most multipotent mesenchymal stromal cells (MSCs) are capable of immune evasion, providing an allogeneic, ready-to-use, cell product option for therapeutic applications. The beneficial effect of MSCs for the treatment of a variety of traumatic injuries, such as open wounds, has been extensively explored. Read More

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http://dx.doi.org/10.1093/abbs/gmaa039DOI Listing

Non-invasive dynamic observation of placental vascular anastomoses in monochorionic twins: Assessment using three-dimensional sonography combined with tomographic ultrasound imaging.

Placenta 2020 Jun 4;95:84-90. Epub 2020 May 4.

Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address:

Introduction: Three-dimensional (3D) sonography combined with tomographic ultrasound imaging (TUI) to observe placental vascular anastomoses in monochorionic diamniotic (MCDA) twin pregnancies was evaluated.

Methods: Women with MCDA twin pregnancies at a gestational age of 16-32 weeks were enrolled in this retrospective study. Placental anastomoses were detected using two-dimensional (2D) and 3D sonography. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.04.015DOI Listing

Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity.

Cancers (Basel) 2020 May 18;12(5). Epub 2020 May 18.

Oncology, Rambam Health Care Center, Haifa 3109601, Israel.

Breast cancer is diagnosed in ~0.3% of pregnant women. Studies that have addressed gestational and neonatal outcomes of chemotherapy during pregnancy have demonstrated increased gestational complications including preeclampsia and intrauterine growth retardation. Read More

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http://dx.doi.org/10.3390/cancers12051277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281110PMC

Mechanistic Basis of ex Vivo Umbilical Cord Blood Stem Progenitor Cell Expansion.

Stem Cell Rev Rep 2020 May 18. Epub 2020 May 18.

Division of Hematology/Oncology, Department of Medicine, University of Illinois College of Medicine Chicago, 840 South Wood Street, Clinical Sciences Building (CSB) Rm# 826, Chicago, IL, 60612, USA.

Umbilical cord blood (CB) transplantation has been used successfully in humans for three decades due to its rapid availability for patients lacking a suitable allogeneic donor, less stringent HLA matching requirements, and low rates of relapse and chronic graft-versus-host disease (GVHD). However, CB transplantation is associated with complications, such as delayed hematopoietic engraftment, graft failure, which increases infection and bleeding and causes longer hospital stays, and transplant-related mortality. The majority of these biological limitations are due to the unforeseeable functional potency of multipotent hematopoietic stem cells (HSCs), which reduce the predictability of successful transplantation; however, several strategies have been developed to increase the number of hematopoietic stem progenitor cells (HSPCs) infused during CB transplantation. Read More

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http://dx.doi.org/10.1007/s12015-020-09981-wDOI Listing

Wharton's jelly area and its association with placental morphometry and pathology.

Placenta 2020 05 23;94:34-38. Epub 2020 Mar 23.

Mouse Imaging Centre, The Hospital for Sick Children, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Department of Obstetrics and Gynecology, University of Toronto, Toronto, Ontario, Canada; Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.

Introduction: Wharton's jelly (WJ) is the mucoid connective tissue that surrounds the vessels in the human umbilical cord and provides protection from compression and torsion in response to fetal movement. WJ is known to be altered in the presence of pregnancy complications such as gestational diabetes mellitus and preeclampsia. The present study examined associations between the cross-sectional area of WJ measured by ultrasound and postpartum placental pathology and morphometry. Read More

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http://dx.doi.org/10.1016/j.placenta.2020.03.008DOI Listing

Intrahepatic cholestasis of pregnancy: are fertilization pregnancies at risk?

J Matern Fetal Neonatal Med 2020 May 18:1-6. Epub 2020 May 18.

Department of Obstetrics and Gynecology, Baskent University, Adana, Turkey.

Single pregnancy patients with intrahepatic cholestasis of pregnancy (ICP) were divided into two groups according to the conception method, as spontaneous and fertilization (IVF). We aim to compare the maternal, laboratory and perinatal characteristics of both groups. The records of 10,929 patients who gave birth in the center between October 2011 and July 2019 were analyzed retrospectively from the data processing system records. Read More

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http://dx.doi.org/10.1080/14767058.2020.1765331DOI Listing

An analysis of the maternal and infant outcomes in the delayed interval delivery of twins.

Taiwan J Obstet Gynecol 2020 May;59(3):361-365

Department of Obstetrics, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, PR China.

Objective: To investigate the treatment methods used for the delayed interval delivery of twins and to evaluate the maternal and infant outcomes.

Materials And Methods: The clinical data of 5 patients that underwent delayed interval delivery of twins at Fujian Maternal and Child Health Hospital from 2014 to 2018 were analyzed. The gestational ages at delivery, obstetrical management, the interval between deliveries, and the maternal and child outcomes were analyzed. Read More

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http://dx.doi.org/10.1016/j.tjog.2020.03.004DOI Listing

Lack of Evidence for Microbiota in the Placental and Fetal Tissues of Rhesus Macaques.

mSphere 2020 May 6;5(3). Epub 2020 May 6.

Department of Biochemistry, Microbiology and Immunology, Wayne State University School of Medicine, Detroit, Michigan, USA

The prevailing paradigm in obstetrics has been the sterile womb hypothesis. However, some are asserting that the placenta, intra-amniotic environment, and fetus harbor microbial communities. The objective of this study was to determine whether the fetal and placental tissues of rhesus macaques harbor bacterial communities. Read More

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http://dx.doi.org/10.1128/mSphere.00210-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203455PMC

Protein and Genetic Expression of CDKN1C and IGF2 and Clinical Features Related to Human Umbilical Cord Length.

J Perinat Med 2020 May 1. Epub 2020 May 1.

Facultad de Salud, Universidad del Sinu, Cartagena, Colombia.

Background Umbilical cord (UC) abnormalities are related to neurological outcome and death; specific molecular factors that might be involved are, as yet, unknown; however, protein-coding genes insulin-like growth factor 2 (IGF2) and cyclin-dependent kinase inhibitor 1C (CDKN1C) have been identified as potential candidates. Methods An analytical observational study was carried out. Newborn UCs were collected, along with their clinical and morphological features. Read More

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http://dx.doi.org/10.1515/jpm-2019-0442DOI Listing

The Effect of Phenylephrine Infusion on Maternal Hemodynamic Changes During Spinal Anesthesia for Cesarean Delivery.

Anesth Pain Med 2020 Feb 12;10(1):e99094. Epub 2020 Feb 12.

Pain Research Center, Department of Anesthesiology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Spinal anesthesia is used as a common anesthetic technique in many routine and outpatient surgeries.

Objectives: The aim of this study was to determine the effect of phenylephrine on maternal hemodynamic changes during spinal anesthesia for cesarean delivery.

Methods: This double-blind randomized controlled trial was conducted on 116 pregnant women candidate for the elective cesarean section through spinal anesthesia in the Shahid Akbarabadi Hospital, Tehran in 2019. Read More

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http://dx.doi.org/10.5812/aapm.99094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144416PMC
February 2020

Topical Umbilical Cord Serum for Corneal Epithelial Defects after Diabetic Vitrectomy.

J Ophthalmic Vis Res 2020 Apr-Jun;15(2):160-165. Epub 2020 Apr 6.

Ophthalmic Epidemiology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Purpose: To evaluate the role of topical umbilical cord serum (TUCS) therapy in treating corneal epithelial defects (CEDs) after diabetic vitrectomy.

Methods: In this double-masked, randomized clinical trial, we included 80 eyes of 80 patients who were candidates for vitrectomy due to proliferative diabetic retinopathy complications. In cases of corneal edema obscuring the fundus view during surgery, the corneal epithelium was removed using a 6-mm trephine and a blade no. Read More

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http://dx.doi.org/10.18502/jovr.v15i2.6732DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7151505PMC

Clinical characteristics and risk assessment of newborns born to mothers with COVID-19.

J Clin Virol 2020 06 10;127:104356. Epub 2020 Apr 10.

Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan University Children's Digital Health and Data Center, Wuhan, China. Electronic address:

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is causing an outbreak of pneumonia in Wuhan, Hubei Province, China, and other international areas.

Objective: Here, we report the clinical characteristics of the newborns delivered by SARS-CoV-2 infected pregnant women.

Methods: We prospectively collected and analyzed the clinical features, laboratory data and outcomes of 7 newborns delivered by SARS-CoV-2 infected pregnant women in Zhongnan Hospital of Wuhan University during January 20 to January 29, 2020. Read More

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http://dx.doi.org/10.1016/j.jcv.2020.104356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194834PMC

Detection of microbial cell-free DNA in maternal and umbilical cord plasma in patients with chorioamnionitis using next generation sequencing.

PLoS One 2020 15;15(4):e0231239. Epub 2020 Apr 15.

Eli and Edythe Broad Center of Regeneration Medicine, University of California, San Francisco, California, United States of America.

Background: Chorioamnionitis has been linked to spontaneous preterm labor and complications such as neonatal sepsis. We hypothesized that microbial cell-free (cf) DNA would be detectable in maternal plasma in patients with chorioamnionitis and could be the basis for a non-invasive method to detect fetal exposure to microorganisms.

Objective: The purpose of this study was to determine whether next generation sequencing could detect microbial cfDNA in maternal plasma in patients with chorioamnionitis. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0231239PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159194PMC

Placental Findings Contributing to Perinatal Death: A 15-Year Retrospective Review from a Teaching Hospital in Thailand.

Fetal Pediatr Pathol 2020 Apr 2:1-11. Epub 2020 Apr 2.

Pathology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The placenta is infrequently examined in developing countries. This study examined the role of placental pathology in perinatal deaths at Chulalongkorn University Hospital, Bangkok. Included were singleton intrauterine deaths after gestational week 20 and live-born infants up to 1 week old, over a 15-year period. Read More

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http://dx.doi.org/10.1080/15513815.2020.1747121DOI Listing

CD133+Exosome Treatment Improves Cardiac Function after Stroke in Type 2 Diabetic Mice.

Transl Stroke Res 2020 Mar 20. Epub 2020 Mar 20.

Department of Neurology, Henry Ford Hospital, Detroit, MI, 48202, USA.

Cardiac complications post-stroke are common, and diabetes exacerbates post-stroke cardiac injury. In this study, we tested whether treatment with exosomes harvested from human umbilical cord blood derived CD133+ cells (CD133+Exo) improves cardiac function in type 2 diabetes mellitus (T2DM) stroke mice. Adult (3-4 m), male, BKS. Read More

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http://dx.doi.org/10.1007/s12975-020-00807-yDOI Listing
March 2020
1.938 Impact Factor

Monitoring Perinatal Exposure to Cannabis and Synthetic Cannabinoids.

Ther Drug Monit 2020 Apr;42(2):194-204

Section of Legal Medicine, Università Politecnica delle Marche, Ancona, Italy.

Purpose: Drug use during pregnancy is a critical global challenge, capable of severe impacts on neonatal development. However, the consumption of cannabis and synthetic cannabinoids is on the rise in pregnant women. Obstetric complications with increased risks of miscarriage, fetal growth restriction, and brain development impairment have been associated with perinatal cannabis exposure, but data on synthetic cannabinoid use during pregnancy are limited. Read More

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http://dx.doi.org/10.1097/FTD.0000000000000667DOI Listing

Challenges and Outcome of Management of Gastroschisis at a Tertiary Institution in North-Eastern Nigeria.

Front Surg 2020 4;7. Epub 2020 Mar 4.

Division of Pediatric Surgery, Department of Surgery, Federal Medical Center, Yola, Nigeria.

Gastroschisis is a congenital anterior abdominal wall defect characterized by herniation of abdominal contents through a defect usually located to the right side of the umbilical cord. It occurs in about 1 in 2,000-4,000 live births and is slightly commoner in males. Management has remained challenging in the low and middle-income countries (LMICS), with high mortality rates. Read More

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http://dx.doi.org/10.3389/fsurg.2020.00008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064440PMC

Neonatal Iron: Factors Influencing its Level and Associated Complications - a Review Article.

Clin Lab 2020 Mar;66(3)

Background: Iron is an essential micronutrient which plays a significant role, particularly vital for early brain growth and function. Maternal iron condition influences the iron status of neonates since iron transferred from the mother is the only source for fetal iron. A depletion in iron as a result of rapid growth leads to iron deficiency which is common in neonates. Read More

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http://dx.doi.org/10.7754/Clin.Lab.2019.190617DOI Listing

Do recent immigrants have similar obstetrical care and perinatal complications as long-term residents? A retrospective exploratory cohort study in Brussels.

BMJ Open 2020 Mar 9;10(3):e029683. Epub 2020 Mar 9.

Obstetrics and Gynecology, CHU St Pierre Université Libre de Bruxelles, Brussels, Belgium

Purpose: Recent immigrants (RIs) face various barriers affecting quality of care. The main research question assessed whether perinatal complications (during pregnancy, labour, delivery and neonatal period) were similar in RIs to those in long-term residents (LTRs). The secondary question assessed whether prenatal and perinatal care was similar in the two groups. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-029683DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064068PMC

Prevalence of vitamin D deficiency in pregnant women and their babies in Bhaktapur, Nepal.

BMC Nutr 2019 29;5:31. Epub 2019 May 29.

2School of Tropical Medicine and Global Health (TMGH), Nagasaki University, Nagasaki, Japan.

Background: Vitamin D deficiency has been observed worldwide in pregnant women and their newborns. Maternal vitamin D deficiency can lead to deficiency in their newborn baby and has been linked with various complications during pregnancy and delivery. There is risk of premature delivery and it is associated with high neonatal mortality. Read More

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http://dx.doi.org/10.1186/s40795-019-0294-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050914PMC

Umbilical access in laparoscopic surgery in infants less than 3 months of age: A survey of the American Pediatric Surgical Association.

J Pediatr Surg 2020 Feb 13. Epub 2020 Feb 13.

Indiana University, Department of Surgery, Division of Pediatric Surgery, Indianapolis, IN.

Purpose: Laparoscopy is commonplace in pediatric surgery. Abdominal access via the umbilicus may present a unique challenge in neonates and young infants predisposing them to complications. We hypothesized that these complications may occur more than described in the literature. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.01.055DOI Listing
February 2020

A giant umbilical cord: Benign finding or surgical emergency?

Clin Case Rep 2020 Feb 20;8(2):398-399. Epub 2020 Jan 20.

University of Saskatchewan Saskatoon SK Canada.

Congenital urachal anomalies are usually asymptomatic. However, infection or obstruction of urachal remnant may result in serious complications. The giant umbilical cords with suspected internal communications could contain remnants and require surgical exploration. Read More

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http://dx.doi.org/10.1002/ccr3.2663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7044356PMC
February 2020

Improving effects of mesenchymal stem cells on symptoms of chronic obstructive pulmonary disease.

Bratisl Lek Listy 2020 ;121(3):188-191

Aim: We aimed to identify the improving effects of umbilical cord tissue-derived (UCTD) MSCs on the symptoms of COPD in our phase 1.2 clinical study.

Material Methods: Our study consisted of five patients with COPD. Read More

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http://dx.doi.org/10.4149/BLL_2020_028DOI Listing
March 2020
0.446 Impact Factor

Serum Bcl-2, caspase-9 and soluble FasL levels as perinatal markers in late preterm pregnancies with intrauterine growth restriction.

Turk J Pediatr 2019 ;61(5):686-696

Departments of Pediatrics, Cumhuriyet University Faculty of Medicine, Sivas, Turkey.

Genç ŞÖ, Karakuş S, Çetin A, Çetin M, Doğan HO, Ünver Korgalı E. Serum Bcl-2, caspase-9 and soluble FasL levels as perinatal markers in late preterm pregnancies with intrauterine growth restriction. Turk J Pediatr 2019; 61: 686-696. Read More

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http://dx.doi.org/10.24953/turkjped.2019.05.007DOI Listing
January 2019

Maternal obesity and the risk of fetal acidosis at birth.

J Matern Fetal Neonatal Med 2020 Feb 25:1-5. Epub 2020 Feb 25.

Department of Obstetrics and Gynecology, Hospital Universitario Virgen de las Nieves, Granada, Spain.

Maternal obesity is a risk factor for multiple obstetrics complications and adverse outcomes. The objective of the study was to investigate the association between obesity (IMC >30) and fetal acidosis at birth. This hospital-based cohort study was based on 24,307 live-born infants in which maternal body mass index (BMI) information was available and delivered in the Granada north region during 2007-2018 from data of the Hospital Medical Birth Registry. Read More

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http://dx.doi.org/10.1080/14767058.2020.1731795DOI Listing
February 2020

Identification of differentially methylated candidate genes and their biological significance in IUGR neonates by methylation EPIC array.

J Matern Fetal Neonatal Med 2020 Feb 24:1-9. Epub 2020 Feb 24.

Department of Biochemistry, JIPMER, Puducherry, India.

Intrauterine growth restriction (IUGR) is a pregnancy-associated disease manifested by decreased growth rate of fetus than the normal genetic growth potential. It is associated with increased susceptibility to metabolic diseases later in life. Although the mechanisms underlying the origin of metabolic diseases are poorly understood, DNA methylation is a crucial investigation for the identification of epigenetic changes. Read More

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http://dx.doi.org/10.1080/14767058.2020.1727881DOI Listing
February 2020

Value of cervicovaginal fluid cytokines in prediction of fetal inflammatory response syndrome in pregnancies complicated with preterm premature rupture of membranes (pPROM).

J Perinat Med 2020 Mar;48(3):249-255

Department of Reproduction, Poznan University of Medical Sciences, Poznań, Poland.

Background Preterm premature rupture of membranes (pPROM) is associated with a high risk of prematurity and complications of fetal inflammatory response syndrome (FIRS). The aim of the study is to determine any correlations between the concentration of selected cytokines contained in the cervicovaginal secretion eluates and in the umbilical cord plasma in patients with pPROM and to find the noninvasive markers of FIRS in order to pinpoint the optimal time of the delivery. Methods The study included 80 patients with pPROM between the 24th and 34th week of gestation. Read More

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http://dx.doi.org/10.1515/jpm-2019-0280DOI Listing

Therapeutic Potential of Wharton's Jelly Mesenchymal Stem Cells for Diabetes: Achievements and Challenges.

Front Cell Dev Biol 2020 29;8:16. Epub 2020 Jan 29.

Biochemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.

Diabetes mellitus (DM) is an alarming metabolic disease in which insulin secreting β-cells are damaged to various extent. Unfortunately, although currently available treatments help to manage the disease, however, patients usually develop complications, as well as decreased life quality and increased mortality. Thus, efficient therapeutic interventions to treat diabetes are urgently warranted. Read More

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http://dx.doi.org/10.3389/fcell.2020.00016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7000356PMC
January 2020

Bioinformatics enrichment analysis of genes and pathways related to maternal type 1 diabetes associated with adverse fetal outcomes.

J Diabetes Complications 2020 May 3;34(5):107556. Epub 2020 Feb 3.

Centre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi 221005, Uttar Pradesh, India. Electronic address:

Maternal type 1 diabetes mellitus (T1DM) may affect fetal development by altering the gene expression profile of the umbilical cord. The present study aimed to explore the T1DM-induced gene expression changes in the fetal umbilical cord. The raw gene expression profiles (ID: GSE51546) of umbilical cord tissue obtained from six normal mothers (non-diabetic) and six type 1 diabetic mothers were used to identify the differentially expressed genes. Read More

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http://dx.doi.org/10.1016/j.jdiacomp.2020.107556DOI Listing

The Potential of Mesenchymal Stem Cells to Treat Systemic Inflammation in Horses.

Front Vet Sci 2019 21;6:507. Epub 2020 Jan 21.

Marion duPont Scott Equine Medical Center, Virginia Maryland College of Veterinary Medicine, Virginia Tech, Leesburg, VA, United States.

One hallmark of mesenchymal stem cells (MSCs) is the ability to differentiate into multiple tissue types which assists in tissue regeneration. Another hallmark of MSCs is their potent anti-inflammatory and immunomodulatory properties and the potential to treat inflammatory, immune-mediated, and ischemic conditions. In equine practice, MSCs have shown efficacy in the treatment of musculoskeletal disorders such as tendinopathy, meniscal tears and cartilage injury. Read More

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http://dx.doi.org/10.3389/fvets.2019.00507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6985200PMC
January 2020

Successful Bone Marrow Recovery After an Immunoablative Regimen With Autologous Cord Blood Transplant in a Child With Idiopathic Severe Aplastic Anemia: A Case Report.

Transplant Proc 2020 Mar 6;52(2):653-656. Epub 2020 Feb 6.

Department of Paediatric Bone Marrow Transplantation, Oncology, and Hematology, Wrocław Medical University, Wroclaw, Poland. Electronic address:

Background: Aplastic anemia is a rare disease that manifests as bone marrow failure. The current treatment options include immunoablative therapy or allogeneic hematopoietic stem cell transplantation. We report a successful immunoablative regimen with autologous umbilical cord blood (auto-UCB) transplant in a 3-year-old boy with severe aplastic anemia. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.12.006DOI Listing

Pregnancy outcomes amongst multiple sclerosis females with third trimester natalizumab use.

Mult Scler Relat Disord 2020 May 30;40:101961. Epub 2020 Jan 30.

The Perron Institute for Neurological and Translational Sciences, QE II Medical Centre, Perth, Australia; Faculty of Medicine, University of Western Australia, Perth, Australia; Institute of Immunology and Infectious Diseases, Murdoch University, Perth, Australia. Electronic address:

Background: Natalizumab, a monoclonal antibody directed against alpha-4-integrin, is an efficacious treatment used in Multiple Sclerosis (MS). Use in early pregnancy is safe but information in the third trimester is limited. Ceasing natalizumab is often associated with an increased risk in MS relapse and in some instances natalizumab continuation during pregnancy may be required. Read More

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http://dx.doi.org/10.1016/j.msard.2020.101961DOI Listing

Outcome of hematopoietic stem cell transplantation (HCT) from HLA-matched related donor for Fanconi anemia (FA) in adolescents and adults: a retrospective study by Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT).

Bone Marrow Transplant 2020 Jul 5;55(7):1485-1490. Epub 2020 Feb 5.

King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.

Hematopoietic Stem Cell Transplantation (HSCT) is the only potentially curative treatment option for the hematologic complications that occur in patients with Fanconi anemia (FA). In this study, we present a retrospective multicenter analysis from the Eastern Mediterranean Blood and Marrow Transplantation Group (EMBMT) of matched related donor HSCT for FA in adolescents and adults transplanted between 1988 and 2015. Forty-five patients received HSCT with a median age at transplant of 18 years, the interquartile range (IQR) (15-23. Read More

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http://dx.doi.org/10.1038/s41409-020-0809-5DOI Listing

Pregnancy outcomes of women with hypoglycemia in the oral glucose tolerance test.

J Gynecol Obstet Hum Reprod 2020 Apr 1;49(4):101703. Epub 2020 Feb 1.

Department of Obstetrics and Gynecology, Tepecik Training and Research Hospital Izmir, 35170, Turkey. Electronic address:

Objective: The aim of this study was to investigate the effects of hypoglycemia measured using 2-h 75-g oral glucose tolerance test (OGTT) on neonatal biometrics (birth weight, head circumference and body length of newborns) and perinatal outcomes.

Materials And Methods: According to the definition of hypoglycemia by the American Diabetes Association, women with blood glucose levels of ≤70 mg/dL after fasting or at 1 or 2 h after eating measured using on 2-h 75-g OGTT were grouped into a hypoglycemia group. In accordance with the criteria of World Health Organization and the International Association of Diabetes and Pregnancy Study Groups, as per the 2-h 75-g OGTT performed in the second trimester, women with gestational diabetes and were excluded from the study. Read More

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http://dx.doi.org/10.1016/j.jogoh.2020.101703DOI Listing

Association between maternal periodontal status and ultrasonographic measurement of fetal growth: A longitudinal study.

Sci Rep 2020 Jan 29;10(1):1402. Epub 2020 Jan 29.

Department of Preventive Dentistry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

The aim of this prospective cohort study was to investigate the association between intrauterine fetal growth patterns and periodontal status in pregnant women. Fifty-three pregnant women were recruited. Periodontitis was diagnosed based on probing pocket depth and clinical attachment level. Read More

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http://dx.doi.org/10.1038/s41598-020-58396-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989493PMC
January 2020

Umbilical cord-matrix stem cells induce the functional restoration of vascular endothelial cells and enhance skin wound healing in diabetic mice via the polarized macrophages.

Stem Cell Res Ther 2020 01 28;11(1):39. Epub 2020 Jan 28.

Department 4, State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Surgery Research, Daping Hospital, Army Medical University, Chongqing, 400042, China.

Background: Chronic nonhealing wounds represent one of the most common complications of diabetes and require advanced treatment strategies. Increasing evidence supports the important role of mesenchymal stem cells in diabetic wound healing; however, the underlying mechanism remains unclear. Here, we explored the effects of umbilical cord-matrix stem cells (UCMSCs) on diabetic wound healing and the underlying mechanism. Read More

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http://dx.doi.org/10.1186/s13287-020-1561-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986138PMC
January 2020

Implantation of allogenic umbilical cord blood-derived mesenchymal stem cells improves knee osteoarthritis outcomes: Two-year follow-up.

Regen Ther 2020 Jun 14;14:32-39. Epub 2020 Jan 14.

Department of Orthopaedic Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Introduction: Clinical outcomes after the implantation of allogenic human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) in osteoarthritic knees have been rarely reported. Our study aimed to investigate clinical outcomes of osteoarthritic patients who underwent hUCB-MSC implantation.

Methods: In this case series (level of evidence: 4), from January 2014 to December 2015, 128 patients with full-thickness cartilage lesions (International Cartilage Repair Society grade 4 and Kellgren-Lawrence grade ≤3) who underwent hUCB-MSC implantation were retrospectively evaluated with a minimum of 2-year follow-up. Read More

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http://dx.doi.org/10.1016/j.reth.2019.10.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965506PMC

Cord Leptin, C-Peptide and Insulin Levels in Large for Gestational Age Newborns in Sri Lanka.

Int J Pediatr 2019 16;2019:4268658. Epub 2019 Dec 16.

Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Ruhuna, Sri Lanka.

Background: Large for gestational age (LGA) infants are more prone to be obese and are at a higher risk of metabolic complications later in life. It is established that Asians have lower skeletal muscle mass and excess body fat for a given body mass index. Thus, objective of this study was to determine the relationship between leptin, insulin, C-peptide in cord blood on the birth weight of newborns and to determine whether these parameters are deviated from data already published from other populations. Read More

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http://dx.doi.org/10.1155/2019/4268658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959154PMC
December 2019

Zika virus detection in amniotic fluid and Zika-associated birth defects.

Am J Obstet Gynecol 2020 06 15;222(6):610.e1-610.e13. Epub 2020 Jan 15.

Instituto Nacional de Salud, Bogotá, Colombia.

Background: Zika virus infection during pregnancy can cause serious birth defects, which include brain and eye abnormalities. The clinical importance of detection of Zika virus RNA in amniotic fluid is unknown.

Objective: The purpose of this study was to describe patterns of Zika virus RNA testing of amniotic fluid relative to other clinical specimens and to examine the association between Zika virus detection in amniotic fluid and Zika-associated birth defects. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.01.009DOI Listing

Complications of umbilical venous catheters in neonates: A safety reappraisal.

Authors:
Chun-Yan Yeung

Pediatr Neonatol 2020 02 7;61(1):1-2. Epub 2020 Jan 7.

Division of Gastroenterology and Nutrition, Department of Pediatrics, MacKay Children's Hospital, No.92, Sec.2, Chung Shan North Road, 10449, Taipei, Taiwan; School of Medicine, MacKay Medical College, No.46, Sec. 3, Zhongzheng Rd., Sanzhi Dist., New Taipei City, 252, Taiwan. Electronic address:

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http://dx.doi.org/10.1016/j.pedneo.2020.01.001DOI Listing
February 2020

Prenatally diagnosed patent urachus with umbilical cord cyst and early surgical intervention.

Ceska Gynekol 2019 ;84(6):425-429

Objective: Description of rare diagnosis of patent urachus.

Design: Case report.

Setting: Department of Obstetrics and Gynecology, 2nd Faculty of Medicine and Faculty Hospital Motol Prague. Read More

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January 2020

Hypereosinophilia (HE) in acute myeloid leukemia (AML) with normal karyotype: A report of two cases.

Niger J Clin Pract 2020 Jan;23(1):116-119

Department of Hematology, Affiliated Changzhou Second Hospital of Nanjing Medical University, Changzhou, Jiangsu, China.

We present two rare cases of hypereosinophilia (HE) in acute myeloid leukemia with normal karyotype (NK-AML) at diagnosis. The first case is a 29-year-old female who presented with HE. On evaluation, she was found to have NK-AML. Read More

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http://dx.doi.org/10.4103/njcp.njcp_585_18DOI Listing
January 2020

Umbilical cord separation time, predictors and healing complications in newborns with dry care.

PLoS One 2020 10;15(1):e0227209. Epub 2020 Jan 10.

Department of Nursing, Faculty of Health Sciences, Universidad de Jaén, Jaén, Spain.

Objective: The objective of this study was to explore the umbilical cord separation time, predictors, and healing complications from birth until the newborn was one month old.

Design: A quantitative longitudinal observational analytical study by stratified random sample was adopted.

Setting: Public health system hospitals in southern Spain and at newborns' homes. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0227209PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953818PMC