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Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):159-164

Department of Anesthesiology, Peking University First Hospital,Beijing 100034, China.

Objective: To analyze the predictive value of umbilical arterial cord pH on complications of hospitalized neonates after cesarean section.

Methods: This was a retrospective cohort study and carried out in Peking University First Hospital from January 1, 2017 to June 30, 2017. Neonates who were delivered by cesarean section were enrolled. Read More

Mol Cell Biochem 2019 Feb 14. Epub 2019 Feb 14.

School of Chemical and Biotechnology, SASTRA Deemed to be University, Thanjavur, Tamil Nadu, India.

Hyperglycaemia during pregnancy is the main reason for developing diabetes mediated vascular complications. Advanced glycation end products (AGEs) are formed due to non-enzymatic glycation of proteins, lipids and nucleic acids during hyperglycaemia. It has the potential to damage vasculature by modifying the substrate or by means of AGEs and receptor of AGE (RAGE) interaction. Read More

Front Immunol 2019 29;10:73. Epub 2019 Jan 29.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Disseminated Bacillus Calmette-Guérin disease (D-BCG) in children with chronic granulomatous disease (CGD) can be fatal, while its clinical characteristics remain unclear because both diseases are extremely rare. The patients with CGD receive BCG vaccination, because BCG vaccination is usually performed within 24 h after delivery in China. We prospectively followed-up Chinese patients with CGD who developed D-BCG to characterize their clinical and genetic characteristics. Read More

J Perinatol 2019 Feb 5. Epub 2019 Feb 5.

Division of Neonatology, University and Polytechnic Hospital La Fe, Valencia, Spain.

Objective: Intraventricular hemorrhage (IVH) is a common complication in extremely preterm infants. We aimed to demonstrate that umbilical cord milking (UCM) would reduce the incidence of IVH in this at risk population.

Study Design: We compared the incidence of IVH in a prospective cohort of consecutively born preterm infants <32 weeks' gestation receiving UCM (n = 33) with a historical cohort that underwent immediate cord clamping (ICC) (n = 36). Read More

Medicine (Baltimore) 2019 Feb;98(5):e14331

Department of Anesthesiology and Intensive Care Medicine, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University.

Background: Phenylephrine is the current "gold standard' vasopressor used to treat maternal hypotension in women undergoing cesarean delivery with spinal anesthesia. Since 2015, various studies have explored the use of norepinephrine to manage maternal hypotension. We conducted this systematic review and meta-analysis of available randomized controlled trials (RCTs) to compare the efficacy and safety of norepinephrine and phenylephrine for the prevention and treatment of maternal hypotension. Read More

Int J Hematol 2019 Jan 24. Epub 2019 Jan 24.

Department of Hematology and Oncology, Konan Kosei Hospital, 137, Omatsubara,Takaya-cho, Konan, 483-8704, Aichi, Japan.

The combination of methotrexate (MTX) and a calcineurin inhibitor is widely used for GVHD prophylaxis in umbilical cord blood transplantation (UCBT). However, the optimal MTX dosage for GVHD prophylaxis in UCBT remains unclear. In the present study, we investigated the impact of MTX dosage on clinical outcomes following UCBT in a single-center retrospective study. Read More

J Clin Ultrasound 2019 Jan 23. Epub 2019 Jan 23.

Department of Obstetrics, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Campus Virchow-Klinikum, Berlin, Germany.

We report a case of a prenatally detected hemangioma of the umbilical cord as an early sign of diffuse neonatal hemangiomatosis (DNH). The newborn was diagnosed with multiple hemangiomas in the liver, intestines, skin, and brain. Prenatal ultrasound findings, neonatal appearance of the hemangiomas, and the associated complications are illustrated. Read More

Anesth Essays Res 2018 Oct-Dec;12(4):769-773

Department of Anaesthesiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.

Background: Labor analgesia has been shown to have few undesirable effects on the course and outcome of the labor as well as on the fetal well-being.

Aims: This study aims to assess neonatal outcome following lumbar epidural analgesia with intermittent boluses of 0.1% bupivacaine with fentanyl. Read More

Arch Gynecol Obstet 2019 Jan 17. Epub 2019 Jan 17.

Department of Laboratory Medicine, Dr. Everett Chalmers Regional Hospital, Horizon Health Network, Fredericton, NB, E3B 5N5, Canada.

Background: Although delayed umbilical cord clamping has been shown to have significant benefits for both term and preterm infants, currently, data on its impact on blood gas analysis have been scant and conflicting.

Methods: In a retrospective review, we compared the demographic characteristics and blood gas parameters of 114 delayed cord clamping (DCC-births between 45 and 90 s in length; 109 being for 60 s) versus 407 early cord clamping births (ECC-immediately after delivery) collected over a 1-year period. Intrapartum care and timing of cord clamping for individual cases were performed at the discretion of obstetricians. Read More

Am J Obstet Gynecol 2019 Feb 25;220(2):191.e1-191.e7. Epub 2018 Oct 25.

Department of Obstetrics and Gynecology, Rambam Health Care Campus, Haifa, Israel; Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. Electronic address:

Background: A low rate of primary cesarean delivery is expected to reduce some of the major complications that are associated with a repeat cesarean delivery, such as uterine rupture, adhesive placental disorders, hysterectomy, and even maternal death. Since 2014, and in alignment with the American College of Obstetricians and Gynecologists and the Society for Maternal-Fetal Medicine, we changed our approach to labor dystocia, defined as abnormal progression of labor, by allowing a longer duration of the second stage of labor.

Objective: To examine the effect of prolonging the second stage of labor on the rate of cesarean delivery, and maternal and neonatal outcomes. Read More

Iran J Child Neurol 2019 ;13(1):45-55

Proteomics Research Center, Department of Basic Sciences, School of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: Delayed umbilical cord clamping (DCC) increases blood transfer to newborns. Hence we investigated the effect of the timing of DCC on hemoglobin levels, neonatal outcomes and developmental status in infants at four months old.

Materials & Methods: This clinical trial examined infants born to 400 pregnant women immediately upon birth and at the age of four months in Isfahan, central Iran in 2016. Read More

J Foot Ankle Surg 2019 Jan;58(1):97-102

Surgeon, OrthoCarolina Foot & Ankle Institute, Charlotte, NC.

Relatively high rates of wound healing complications continue to be reported with a total ankle arthroplasty (TAA) anterior incision. The amniotic membrane-umbilical cord (AM-UC) allograft is a regenerative orthobiologic adjunct that modulates wound healing by down-regulating inflammation, enhancing local healing and antimicrobial factors, and reducing scar formation. The purpose of this study was to determine whether local application of a cryopreserved AM-UC allograft enhances soft tissue healing after TAA. Read More

Int J Womens Health 2018 28;10:783-795. Epub 2018 Nov 28.

Institute of Human Genetics, The Medical School, Pontificia Universidad Javeriana, Bogota, Colombia.

Introduction: The VEGF family has been identified as abnormal in preeclampsia (PE). Hypertensive disorders of pregnancy (HDP) are major contributors to maternal and neonatal morbidity and mortality worldwide; likewise, umbilical cord anatomical abnormalities (UCAA) are linked to poor neonatal outcomes. Based on the relationship described between PE and UCAA and the role of the VEGF family in PE, this study explored VEGF expression in placental and UC tissued from patients with PE and with UCAA. Read More

Rev Argent Microbiol 2018 Dec 9. Epub 2018 Dec 9.

Laboratorio de Bacteriología Clínica, Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Córdoba, CABA, Argentina. Electronic address:

The etiology leading to neonatal damage is multifactorial, being genital infections one of the causes. The objective of the study was to identify microorganisms of the maternal genital tract that are associated with neonatal damage, in order to prevent future perinatal complications. Seven hundred and eleven pregnant patients attended their prenatal control during the period January 2010-July 2013. Read More

Virus Res 2019 01 5;260:151-162. Epub 2018 Dec 5.

Western College of Veterinary Medicine, University of Saskatchewan, S7N 5B4, Canada. Electronic address:

Although porcine reproductive and respiratory syndrome virus (PRRSV) readily crosses the maternal fetal interface (MFI) in third trimester, fetal resilience varies within litters. The aim of this study was to characterize PRRSV-2 concentration in MFI and fetuses at five time points after experimental inoculation of late gestation gilts and use this information to classify potentially resistant, resilient and susceptible fetuses. The secondary objective was to verify the relationship between PRRS viral load and intrauterine growth retardation (IUGR). Read More

PLoS One 2018 3;13(12):e0207952. Epub 2018 Dec 3.

FutureNeuro Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.

MicroRNAs are a class of small non-coding RNA that regulate gene expression at a post-transcriptional level. MicroRNAs have been identified in various body fluids under normal conditions and their stability as well as their dysregulation in disease has led to ongoing interest in their diagnostic and prognostic potential. Circulating microRNAs may be valuable predictors of early-life complications such as birth asphyxia or neonatal seizures but there are relatively few data on microRNA content in plasma from healthy babies. Read More

Am J Clin Exp Immunol 2018 5;7(5):88-94. Epub 2018 Oct 5.

Department of Neurology, Liaocheng People's Hospital, Liaocheng Clinical School, Taishan Medical University Liaocheng, PR China.

Multiple system atrophy is a sporadic progressive degenerative disease which is characterized by multiple central nervous systems involved. So far, there is no effective medicine to cure MSA. The main research direction of treatment includes immunization transplantation and cytotherapy. Read More

Medicine (Baltimore) 2018 Nov;97(47):e13287

Department of Pediatrics, Shandong Provincial Qianfoshan Hospital of Shandong University, Jinan, China.

Rationale: To explore the curative effect of human umbilical cord-derived mesenchymal stem cell (ucMSC) therapy for patients with liver cirrhosis complicated with immune thrombocytopenia and refractory Henoch-Schonlein purpura (HSP).

Patient Concerns: A 12-year-old boy presented to our hospital with an 11-month history of purpura on the skin of both lower limbs accompanied by thrombocytopenia. The patient had a history of repeated swelling and painful dorsum pedis, followed by skin redness. Read More

Open Neuroimag J 2018 17;12:55-65. Epub 2018 Oct 17.

Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States.

Background: Neonatal hypoxic-ischemic encephalopathy is brain injury caused by decreased perfusion and oxygen delivery that most commonly occurs in the context of delivery complications such as umbilical cord compression or placental abruption. Imaging is a key component for guiding treatment and prediction of prognosis, and the most sensitive clinical imaging modality for the brain injury patterns seen in hypoxic-ischemic encephalopathy is magnetic resonance imaging.

Objective: The goal of this review is to compare magnetic resonance imaging findings demonstrated in the available animal models of hypoxic-ischemic encephalopathy to those found in preterm (≤ 36 weeks) and term (>36 weeks) human neonates with hypoxic-ischemic encephalopathy, with special attention to the strengths and weaknesses of each model. Read More

Medicine (Baltimore) 2018 Nov;97(46):e11889

Cochrane China, West China Hospital, Sichuan University, Chengdu, China.

Background: Varied regimens of penicillin antibiotics were given to women for preventing infection after cesarean section, but there is no study compares the effectiveness and safety of them.

Methods: We searched MEDLINE, Embase, CENTRAL, CNKI, Wanfang, VIP, and CBM Database, and contacted experts in the field and searched reference lists of retrieved studies. We included randomized controlled trials comparing different regimens of penicillin antibiotics given to women after cesarean section. Read More

Stem Cell Res Ther 2018 Nov 14;9(1):312. Epub 2018 Nov 14.

Department of Rheumatology and Immunology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing, Jiangsu, CN 210008, People's Republic of China.

Objective: The aim of this study was to evaluate the safety of mesenchymal stem cell infusion in patients with autoimmune diseases.

Methods: A total of 404 patients with autoimmune diseases who received mesenchymal stem cell infusion between 2007 and 2016 were included in this study. Adverse events in these patients were collected, mainly including infections and malignancies. Read More

BMC Pregnancy Childbirth 2018 Nov 14;18(1):443. Epub 2018 Nov 14.

Department of Sonography, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Monochorionic diamniotic (MCDA) twin pregnancies are at higher risk of adverse outcomes and complications, which are attributed to the influence of placental morphology in MCDA twins. Monitoring of placental function is an important index for clinical decisions. The aim of our study was to evaluate the placental blood flow estimated using three-dimensional power Doppler (3D-PD) ultrasound and the vascular indices distribution with gestational age (GA) in normal MCDA twin pregnancies. Read More

J Matern Fetal Neonatal Med 2018 Nov 14:1-12. Epub 2018 Nov 14.

b Biomedical Informatics Centre, Indian Council of Medical Research , National Institute of Pathology , New Delhi, India.

Introduction: Tobacco-smoking is one of the most important risk factor for preterm delivery, pregnancy loss, low birth weight, and fetal growth restriction. It is estimated that approximately 30% of growth-restricted neonates could be independently associated with maternal smoking.

Methods: In this study, gene expression profile, GSE11798, was chosen from GEO database with an aim to perceive change in gene expression signature in new born due to maternal smoking. Read More

Lab Chip 2018 12;18(24):3780-3789

School of Biomedical Engineering, McMaster University, Hamilton, ON, Canada.

Many neonates who are born premature suffer from respiratory distress syndrome (RDS) for which mechanical ventilation and an extracorporeal membrane oxygenation (ECMO) device are used in treatment. However, the use of these invasive techniques results in higher risk of complications like bronchopulmonary dysplasia or requires surgery to gain vascular access. An alternative biomimetic approach is to use the umbilical cord as a vascular access and to connect a passive device to the baby that functions like a placenta. Read More

Semin Pediatr Surg 2018 Oct 5;27(5):289-299. Epub 2018 Sep 5.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of California Irvine Medical Center, Orange, CA, USA. Electronic address:

Gastroschisis is a congenital, ventral wall defect associated with bowel evisceration. The defect is usually to the right of the umbilical cord insertion and requires postnatal surgical correction. The fetus is at risk for complications such as intrauterine growth restriction, preterm delivery, and intrauterine fetal demise. Read More

Semin Pediatr Surg 2018 Oct 27;27(5):283-288. Epub 2018 Aug 27.

Service de Chirurgie Pédiatrique, Hôpital Universitaire Necker Enfants Malades, APHP, Paris, France; Département d'Anatomie et Morphogenèse, Université Paris Descartes, Paris, France. Electronic address:

The development of gastroschisis has long remained an area of interest and controversy. Successive theories about its pathogenesis are herein reviewed and discussed. Two historical assumptions, that omphalocele results from a persistent umbilical hernia, and that gastroschisis does not involve the umbilical cord, are dismissed. Read More

Cochrane Database Syst Rev 2018 10 31;10:CD012794. Epub 2018 Oct 31.

Division of Vascular and Endovascular Surgery, Department of Surgery, UNIFESP - Escola Paulista de Medicina, Rua Borges Lagoa, 564 cj 124, Vila Clementino, São Paulo, Brazil, 04038000.

Background: Thromboangiitis obliterans, also known as Buerger's disease, is a non-atherosclerotic, segmental inflammatory pathology that most commonly affects the small- and medium-sized arteries, veins, and nerves in the upper and lower extremities. The etiology is unknown, but involves hereditary susceptibility, tobacco exposure, immune and coagulation responses. In many cases, there is no possibility of revascularization to improve the condition. Read More

APMIS 2018 Dec 30;126(12):899-906. Epub 2018 Oct 30.

Department of Microbiology, Oslo University Hospital, University of Oslo, Oslo, Norway.

CMV is the most common cause of congenital infection. During the past few decades, there has been a change in behaviour that possibly has affected the CMV infection rate of mother and child. We investigated 1350 randomly selected pregnant women from the Norwegian Mother and Child Cohort Study using an algorithm for detection of maternal and congenital CMV (cCMV) infection including both serology and nucleic acid amplification assay. Read More

Eur J Pediatr 2019 Feb 29;178(2):173-179. Epub 2018 Oct 29.

Department of Pediatrics, Division of Neonatology, Cohen Children's Medical Center, New Hyde Park, NY, USA.

The primary objective was to study agreement between X-rays and point of care ultrasound (POC-US) in determining central venous line (CVL) tip position. The secondary objective was to examine malposition rates over time using POC-US. Fifty-six neonates were enrolled who had a CVL placed. Read More

Exp Clin Transplant 2018 Oct 19. Epub 2018 Oct 19.

From the Immunology Department, Theodor Bilharz Research Institute, Giza, Egypt.

Objectives: Liver transplantation is the well-known treatment for chronic liver diseases; however, postoperative complications and lack of donors continue to be limitations with this treatment. Investigating new modalities for treatment of chronic liver illness is a must. In the present study, we aimed to clarify the effects of an in vitro hepatocyte-differentiated human unrestricted somatic stem cell transplant as a new cell-based therapy in an experimental model of chronic liver failure. Read More

Biol Blood Marrow Transplant 2018 Oct 18. Epub 2018 Oct 18.

National Cancer Institute, National Institutes of Health, Bethesda, Maryland. Electronic address:

Human cytomegalovirus (CMV) infection and disease remains a significant cause of morbidity and mortality for hematopoietic cell transplantation (HCT) recipients. Disruption of or weak reconstitution of virus-specific cellular immune function, such as with certain HCT approaches, poses significant risk for CMV-related complications. The incidence of and risk factors for CMV infection and the nature of CMV disease were evaluated retrospectively among 356 consecutive HCT recipients transplanted at the National Institutes of Health using all graft sources, including bone marrow, peripheral blood stem cell (PBSC), and umbilical cord blood (UCB), and a range of in vivo and ex vivo approaches for graft-versus-host disease (GVHD) prophylaxis. Read More

Taiwan J Obstet Gynecol 2018 Oct;57(5):672-676

Department of Obstetrics and Gynecology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Objective: Umbilical cord entanglement is known to be a major cause of fetal hypoxia and to be correlated with several neonatal complications, but almost all of the previous reports were restricted to nuchal cord. In this study, we retrospectively examined the correlation between multiple part cord entanglement and pregnancy outcomes.

Materials And Methods: A total of 2156 cases were recruited from term deliveries in our hospital from 2008 to 2012. Read More

BMJ Open 2018 Oct 17;8(10):e022562. Epub 2018 Oct 17.

Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud.

Objective: To define and compare the reference interval of B-type natriuretic peptide (BNP) in healthy newborns (HN) from healthy mothers and with severe pre-eclampsia.

Design: Prospective, multicentre, cross-sectional study.

Setting: Four obstetric wards of second-level academic hospitals. Read More

BMJ Case Rep 2018 Oct 8;2018. Epub 2018 Oct 8.

Division of Neonatology, Department of Pediatrics, Regina General Hospital, Regina, Saskatchewan, Canada.

The ease of access and advantages of a secure central line makes use of umbilical venous catheter (UVC) and umbilical artery catheters a part of the standard of care in the extremely premature babies in the neonatal intensive care unit. However, there are complications associated with their use. One of the uncommon complications reported is total parenteral nutrition (TPN) ascites secondary to vessel perforation or hepatic erosion by the tip of the catheter due to malposition of a UVC. Read More

J Dev Orig Health Dis 2018 Oct 8:1-5. Epub 2018 Oct 8.

3Epidemiology and Biostatistics Program,Division of Cancer Epidemiology and Genetics,National Cancer Institute,Bethesda,MD,USA.

In addition to being associated with a higher risk of complications during pregnancy, twinning may also be a proxy for altered hormonal exposure for mothers and twin offspring, with implications for their health later in life. We compared maternal and fetal steroid hormone and insulin-like growth factor concentrations between singleton (n=62) and twin (n=41) pregnancies. Maternal concentrations of androgens, estrogens, insulin-like growth factor (IGF)-1, IGF-binding protein (BP)-3 and prolactin were quantified during the third trimester and at delivery, as well as in the fetal circulation at birth. Read More

J Paediatr Child Health 2018 Oct 4. Epub 2018 Oct 4.

Division of Neonatology, Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey.

Aim: To compare the post-natal effects of delayed cord clamping (DCC) and early cord clamping (ECC) in term large-for-gestational age (LGA) infants.

Methods: This prospective randomised study included 51 term LGA infants. The umbilical cords of these infants were clamped at 15 s in group 1 (ECC group (n = 26)) and at 60 s in group 2 (DCC group (n = 25)). Read More

Trials 2018 Sep 27;19(1):524. Epub 2018 Sep 27.

Department of Obstetrics and Gynecology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.

Background: Congenital diaphragmatic hernia is an orphan disease with high neonatal mortality and significant morbidity. An important cause for this is pulmonary hypertension, for which no effective postnatal therapy is available to date. An innovative strategy aiming at treating or preventing pulmonary hypertension more effectively is urgently needed. Read More

Arch Biochem Biophys 2018 Dec 25;659:13-21. Epub 2018 Sep 25.

Department of Biochemistry, Faculty of Pharmacy, Cairo University, Kasr El Ainy st, Cairo, 11562, Egypt. Electronic address:

Background: Pre-eclampsia (PE) is one of the most threatening pregnancy complications. So far neither a secure, competent therapy for PE nor effective biomarkers for a premature discovery has been achieved. However, currently, the use of released microRNAs (miRNAs) as potential biomarkers and therapy targets for various diseases is the dominating area of research. Read More

Zhonghua Yi Xue Za Zhi 2018 Sep;98(35):2832-2837

Center for Reproductive Medicine, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China.

To evaluate the prognosis and complications after reduction of monochorionic multifetal pregnancies using bipolar umbilical cord coagulation (BCC) or radiofrequency ablation (RFA). A literature search were performed by using online databases including PubMed, Embase, and COCHRANE.The publications that described prognosis and complications after selective reduction of monochorionic twin pregnancies using either BCC or RFA for studies with clear outcome data were identified. Read More

J Pregnancy 2018 2;2018:2195965. Epub 2018 Sep 2.

Department of Oncology and Metabolism, Academic Unit of Reproductive & Developmental Medicine, 4th Floor Jessop Wing, Tree Root Walk, Sheffield S102SF, UK.

Background: Despite major advances in perinatal medicine, intrapartum asphyxia remains a leading and potentially preventable cause of perinatal mortality and long-term morbidity. The umbilical cord pH is considered an essential criteria for the diagnosis of acute intrapartum hypoxic events. The purpose of this study was to evaluate whether obstetric risk factors are associated with fetal acidaemia at delivery. Read More

Stem Cell Res Ther 2018 Sep 21;9(1):238. Epub 2018 Sep 21.

Stem Cells and Regenerative Medicine Department, King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard Health Affairs, P.O. Box 22490, Mail Code 1515, Riyadh, 11426, Saudi Arabia.

Background: Mesenchymal stem/stromal cells derived from chorionic villi of human term placentae (pMSCs) protect human endothelial cells from injury induced by hydrogen peroxide (HO). In diabetes, elevated levels of glucose (hyperglycaemia) induce HO production, which causes the endothelial dysfunction that underlies the enhanced immune responses and adverse complications associated with diabetes, which leads to thrombosis and atherosclerosis. In this study, we examined the ability of pMSCs to protect endothelial cell functions from the negative impact of high level of glucose. Read More

Int J Reprod Biomed (Yazd) 2018 Jul;16(7):429-434

Department of Pediatrics, Faculty of Medicine Sciences, Mashhad University o Medical Sciences, Mashhad, Iran.

Background: Intra-ventricular hemorrhage (IVH) is acute cerebral complications of premature infants which may lead to the long-term problems.

Objective: According to the role of vitamin D in the stability of the blood vessels, the present study was carried out in order to compare the vitamin D level in the premature infants with or without IVH.

Materials And Methods: This cross-sectional study was carried out on 180 premature infants in the Ghaem Hospital, Mashhad, Iran 97 infants without IVH (53. Read More

Stem Cells Int 2018 15;2018:5268057. Epub 2018 Aug 15.

Department of Neonatology, Guangdong Women and Children Hospital, Guangzhou, China.

Background: Preterm birth complications are one of the leading causes of death among children under 5 years of age. Despite advances in medical care, many survivors face a lifetime of disability, including mental and physical retardation, and chronic lung disease. More recently, both allogenic and autogenic cord blood cells have been applied in the treatment of neonatal conditions such as hypoxic-ischemic encephalopathy (HIE) and bronchopulmonary dysplasia (BPD). Read More

J Nephrol 2019 Feb 29;32(1):17-25. Epub 2018 Aug 29.

Department of Public Health, University Federico II, Via Pansini 5, 80131, Naples, Italy.

Pregnancy can be a dangerous trigger for patients with paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), or hemolysis, elevated liver enzymes and low platelet (HELLP) syndrome. Due to the possibility of several serious complications, pregnancy is somewhat discouraged in the presence of the above diseases. Eculizumab is a humanized antibody that may dramatically change the clinical course of PNH, aHUS and HELLP syndrome. Read More

APMIS 2018 Jul;126(7):561-569

Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Fetal vascular malperfusion is the most recent term applied to a group of placental lesions indicating reduced or absent perfusion of the villous parenchyma by the fetus. The most common etiology of malperfusion is umbilical cord obstruction leading to stasis, ischemia, and in some cases thrombosis. Other contributing factors may include maternal diabetes, fetal cardiac insufficiency or hyperviscosity, and inherited or acquired thrombophilias. Read More

Adv Biomed Res 2018 20;7:111. Epub 2018 Jul 20.

Department of Obstetrics and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Given the high prevalence of adverse perinatal outcome in the developing countries and the association between uterine artery (UtA) blood flow and fetal status in the uterine, in the current study, we assess the association between UtA pulsatility index (UtA-PI) at 30-34 week's gestation and adverse perinatal outcome.

Materials And Methods: This cohort study included 100 pregnant women at 30-34 weeks' gestation. At baseline, UtA-PI was evaluated with color Doppler through abdominal ultrasound. Read More

Taiwan J Obstet Gynecol 2018 Aug;57(4):483-486

Faculty of Medicine, Mansoura University, Egypt.

Objective: Intrauterine growth restriction (IUGR) is one of the most serious complications of pregnancy. Up to date, there is no evidence of achieving antenatal treatment of IUGR with abnormal placentation. Although, Sildenafil citrate has shown promising results, there are no firm conclusion till now. Read More

JIMD Rep 2019 17;44:93-101. Epub 2018 Aug 17.

Department of Medical Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.

Fabry disease (FD) is an X-linked, lysosomal storage disease. Mutations in the gene coding for alpha-galactosidase A lead to globotriaosylceramide (Gb-3) accumulation in lysosomes and in placenta and umbilical cord. Impact of FD and treatment with enzyme replacement (ERT) on foetal development is undisclosed. Read More

BJOG 2019 Jan 24;126(1):24-31. Epub 2018 Sep 24.

Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.

Objective: To compare fetal microchimerism (FMc) in pregnancies with uncomplicated vaginal delivery (VD) versus caesarean delivery (CD).

Design: Prospective cohort study.

Setting: University of Washington and Fred Hutchinson Cancer Research Center, USA. Read More