493 results match your criteria Ultraviolet Keratitis

Xeroderma pigmentosum: an updated review.

Drugs Context 2022 25;11. Epub 2022 Apr 25.

Department of Paediatrics, Hong Kong Institute of Integrative Medicine, The Chinese University of Hong Kong, Hong Kong.

Background: Early recognition of xeroderma pigmentosum is important to minimize the complications arising from the harmful effects of exposure to ultraviolet radiation. This narrative review aims to familiarize physicians with the clinical features, diagnosis and management of xeroderma pigmentosum.

Methods: A search was conducted in December 2021 in PubMed Clinical Queries using the key term "xeroderma pigmentosum". Read More

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Photo-activated chromophore for infectious keratitis cross-linking and its efficacy as a treatment modality in managing microbial keratitis.

Indian J Ophthalmol 2022 05;70(5):1571-1577

Department of Ophthalmology, Regional Institute of Ophthalmology, Government M. D. Eye Hospital, Prayagraj (Allahabad), Uttar Pradesh, India.

Purpose: To assess Photo Activated Chromophore for Infective Keratitis-Cross Linking (PACK-CXL) and its efficacy as a treatment modality in managing microbial keratitis.

Methods: Single Centre prospective interventional study in infectious keratitis. A total of eleven patients were taken who had corneal thickness (CT) more than 400μm. Read More

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Activation of the STAT5 Signaling Pathway by Yiqi Jiedu Formula Induces Regulatory T Cell-Mediated Alleviation of Corneal Immunopathological Damage in Mice With Recurrent Herpes Simplex Keratitis.

Front Pharmacol 2021 21;12:790787. Epub 2022 Jan 21.

Department of Ophthalmology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.

This study aimed to investigate the effect of Yiqi Jiedu (YQJD) formula on the repair of corneal lesions in mice with recurrent herpes simplex virus keratitis (HSK). Sixty female BALB/c mice were randomly divided into three groups: a normal control group (Naive), a recurrence model group (Re), and a YQJD group. After inducing recurrence by ultraviolet irradiation, the ocular surfaces of different groups of mice were observed using a slit lamp and photographed, and ocular surface scores were calculated. Read More

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January 2022

Preparation and Evaluation of Starch Hydrogel/Contact Lens Composites as Epigallocatechin Gallate Delivery Systems for Inhibition of Bacterial Adhesion.

Front Bioeng Biotechnol 2021 16;9:759303. Epub 2021 Nov 16.

Qingdao Eye Hospital of Shandong First Medical University, Qingdao, China.

Microbial infections caused by wearing contact lenses has become a major health problem, so the design and development of antibacterial contact lenses has attracted widespread attention. To safely and effectively inhibit bacterial adhesion of contact lenses, we have facilely prepared epigallocatechin gallate (EGCG) loaded starch hydrogel/contact lens composites by free radical polymerization of the mixture containing 2-hydroxylethyl methacrylate, methacrylic acid and ethylene glycol dimethacrylate. The adequate transmittance of the resulting contact lenses was characterized by ultraviolet-visible spectrophotometry, and their satisfactory stability was examined using differential scanning calorimetry and thermogravimetric analysis. Read More

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November 2021

[Alterations of the anterior segment of the eye caused by exposure to UV radiation].

Ophthalmologe 2022 Mar 3;119(3):234-239. Epub 2021 Dec 3.

Poliklinik und Klinik, Universitätsmedizin Mainz, Langenbeckstr 1, 55131, Mainz, Deutschland.

Background: By identifying diseases of the anterior segment of the eye associated with exposure to UV light, recommendations for action can be derived.

Aim: After reading this review, the reader should be familiar with UV light-associated diseases of the anterior segment of the eye.

Method: Using a selective literature search, UV light-associated diseases of the anterior segment of the eye were identified and protective mechanisms are described. Read More

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Rapid spontaneous resolution of corneal hydrops in post-CXL keratitis.

BMJ Case Rep 2021 Nov 30;14(11). Epub 2021 Nov 30.

Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India.

An 11-year-old boy presented with right eye post-Corneal Collagen Cross-Linking (CXL) keratitis, which was complicated by acute corneal hydrops (CH). Keratitis was managed by topical antibiotics, and CH was managed conservatively. Cornea was monitored with serial anterior segment optical coherence tomography (ASOCT) scans. Read More

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November 2021

Polymicrobial keratitis after accelerated corneal collagen cross-linking in keratoconus: Case reports and literature review.

Eur J Ophthalmol 2022 May 25;32(3):1375-1385. Epub 2021 Nov 25.

159374Eye Center of Xiangya Hospital, Central South University, Changsha, China.

Purpose: To report two cases of polymicrobial keratitis following corneal collagen cross-linking for keratoconus and to review the literature.

Methods: Retrospective case note and literature review.

Results: The first case involved a 27-year-old male who presented with amebic corneal ulcers 3 days after the collagen cross-linking procedure. Read More

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Adverse events after riboflavin/UV-A corneal cross-linking: a literature review.

Int Ophthalmol 2022 Jan 27;42(1):337-348. Epub 2021 Aug 27.

Studio Italiano di Oftalmologia, Via Livenza 3, 00198, Rome, Italy.

Background: Riboflavin/UV-A corneal cross-linking (CXL) for treating keratoconus and iatrogenic corneal ectasia has been well-established as first treatment option to stabilize corneal tissue biomechanical instability. Although the plethora of clinical studies has been published into the field, there is no systematic review assessing the type and frequency of adverse events after CXL.

Methods: A systemic literature review on clinical safety and adverse events after CXL in patients with keratoconus and corneal ectasia was performed using PubMed. Read More

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January 2022

Silver Nanoparticles Using Eucalyptus or Willow Extracts (AgNPs) as Contact Lens Hydrogel Components to Reduce the Risk of Microbial Infection.

Molecules 2021 Aug 19;26(16). Epub 2021 Aug 19.

Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.

Eucalyptus leaves (ELE) and willow bark (WBE) extracts were utilized towards the formation of silver nanoparticles (AgNPs(ELE), AgNPs(WBE)). AgNPs(ELE) and AgNPs(WBE) were dispersed in polymer hydrogels to create [email protected](ELE)_2 and [email protected](WBE)_2 using hydroxyethyl-methacrylate (HEMA). The materials were characterized in a solid state by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), thermogravimetric differential thermal analysis (TG-DTA), differential scanning calorimetry (DTG/DSC) and attenuated total reflection spectroscopy (ATR-FTIR) and ultraviolet visible (UV-vis) spectroscopy in solution. Read More

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Anandamide Concentration-Dependently Modulates Toll-Like Receptor 3 Agonism or UVB-Induced Inflammatory Response of Human Corneal Epithelial Cells.

Int J Mol Sci 2021 Jul 21;22(15). Epub 2021 Jul 21.

Department of Immunology, Faculty of Medicine, University of Debrecen, Egyetem tér 1, 4032 Debrecen, Hungary.

Photodamage-induced and viral keratitis could benefit from treatment with novel nonsteroid anti-inflammatory agents. Therefore, we determined whether human corneal epithelial cells (HCECs) express members of the endocannabinoid system (ECS), and examined how the endocannabinoid anandamide (AEA, N-arachidonoyl ethanolamine) influences the Toll-like receptor 3 (TLR3) agonism- or UVB irradiation-induced inflammatory response of these cells. Other than confirming the presence of cannabinoid receptors, we show that endocannabinoid synthesizing and catabolizing enzymes are also expressed in HCECs in vitro, as well as in the epithelial layer of the human cornea in situ, proving that they are one possible source of endocannabinoids. Read More

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Corneal Cross-Linking: The Evolution of Treatment for Corneal Diseases.

Front Pharmacol 2021 19;12:686630. Epub 2021 Jul 19.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Corneal cross-linking (CXL) using riboflavin and ultraviolet A (UVA) light has become a useful treatment option for not only corneal ectasias, such as keratoconus, but also a number of other corneal diseases. Riboflavin is a photoactivated chromophore that plays an integral role in facilitating collagen crosslinking. Modifications to its formulation and administration have been proposed to overcome shortcomings of the original epithelium-off Dresden CXL protocol and increase its applicability across various clinical scenarios. Read More

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In vitro affinity for nicotine of soft contact lenses of different materials.

Cont Lens Anterior Eye 2021 Jul 19:101490. Epub 2021 Jul 19.

University of Milano Bicocca, Materials Science Department, via R. Cozzi 55, I-20125 Milan, Italy; University of Milano Bicocca, COMiB Research Center, via R. Cozzi 55, I-20125 Milan, Italy.

Smoking is a risk factor for the development of microbial keratitis and corneal infiltrates in contact lens (CL) wearers. It is still unknown if this risk is directly associated with the presence of nicotine in the eye and if adherence of nicotine on the CL can enhance these effects. A better understanding of the interaction between nicotine and CL materials could offer insights to explain this risk associated with smoking. Read More

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Increased photokeratitis during the coronavirus disease 2019 pandemic: Clinical and epidemiological features and preventive measures.

Medicine (Baltimore) 2021 Jun;100(24):e26343

The First Affiliated Hospital of Soochow University.

Abstract: An increased incidence of photokeratitis has occurred during the coronavirus disease 2019 (COVID-19) pandemic due to improper and unprotected use of ultraviolet lamps. Here, we summarize the clinical and epidemiological features of this increased incidence of photokeratitis and share advice in using health education to prevent it.We collected data from patients diagnosed with photokeratitis from October 7, 2019 to December 1, 2019, and from February 17, 2020 to April 12, 2020, and compared the frequency of onset, site of ultraviolet radiation (UVR) exposure, reason for exposure, exposure time, and recovery time. Read More

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Diffuse Lamellar Keratitis in a Patient Undergoing Collagen Corneal Cross-Linking 18 Years After Laser In Situ Keratomileusis Surgery.

Cornea 2021 Jul;40(7):917-920

Vance Thompson Vision, Omaha, NE.

Purpose: To report a case of diffuse lamellar keratitis (DLK) after corneal collagen cross-linking in an eye with a remote history of laser in situ keratomileusis (LASIK) surgery.

Methods: This is a case report and literature review.

Results: This report describes the development of unilateral stage IV DLK in a patient who underwent bilateral corneal cross-linking for corneal ectasia 18 years after LASIK surgery. Read More

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Comparison of modified corneal cross-linking with intrastromal voriconazole for the treatment of fungal corneal ulcer.

Exp Ther Med 2021 Jul 21;22(1):786. Epub 2021 May 21.

Department of Dermatology, General Hospital of Northern Theater Command, Shenyang, Liaoning 110016, P.R. China.

The present study aimed to evaluate the efficacy of modified corneal cross-linking (CXL) for the treatment of fungal corneal ulcers compared with that following intrastromal voriconazole injection. In total, 31 patients with fungal corneal ulcers treated at The General Hospital of Northern Theater Command between October 2017 and October 2019 were enrolled. Among them, 10 eyes were treated with ultraviolet A (UV-A)/riboflavin CXL (CXL group), whilst 21 eyes were treated with debridement combined with intrastromal voriconazole (stromal injection group). Read More

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The Role of Environmental Factors in the Epidemiology of Infectious Bovine Keratoconjunctivitis.

Vet Clin North Am Food Anim Pract 2021 Jul;37(2):309-320

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 784 Wilson Road, Room G-100, East Lansing, MI 48824, USA.

Environmental factors that contribute to the pathogenesis of infectious bovine keratoconjunctivitis (IBK) include face flies, ultraviolet (UV) radiation, and mechanical irritation from plant awns or dust. Limited research has shown face fly control to be associated with lower incidence of IBK. UV radiation is known to cause corneal irritation and damage in mammalian species. Read More

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Alternative indications for corneal crosslinking.

J Cataract Refract Surg 2021 Oct;47(10):1360-1366

Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium (Van Tigchelt, Van Eijgen, Delbeke), the KU Leuven, Biomedical Sciences Group, Department of Neurosciences, Research group Ophthalmology, Leuven, Belgium (Van Eijgen, Delbeke), the VITO (Flemish Institute for Technological Research), Health Unit, Mol, Belgium (Van Eijgen).

Corneal crosslinking (CXL) is the current mainstay treatment for progressive keratoconus. In the past 15 years, a variety of other indications have been tested. A systematic review was conducted to examine these alternative indications for CXL. Read More

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October 2021

[Crosslinking and Keratoconus].

Klin Monbl Augenheilkd 2021 Jun 19;238(6):733-747. Epub 2021 Apr 19.

Keratoconus leads to a progressive protrusion and thinning of the cornea. In order to stop this, corneal crosslinking can be performed if the progression of the disease is proven. Crosslinking according to the "Dresden protocol" includes abrasion of the corneal epithelium, application of riboflavin eye drops and irradiation with UV-A light of an intensity of 3 mW/cm² for 30 minutes. Read More

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Clinically Compatible Fluorescence Microscopy Based on Moxifloxacin Antibiotic.

Adv Exp Med Biol 2021 ;1310:91-113

Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea.

High-resolution fluorescence tissue imaging with the application of moxifloxacin as a cell-labelling agent is described. Moxifloxacin is an antibiotic used in the clinic to both treat and prevent bacterial infections, and it has both good pharmacokinetic properties for tissue penetration and intrinsic fluorescence under ultraviolet (UV) excitation. Alternative usage of moxifloxacin as the cell-labelling agent was discovered and its imaging applications have been explored. Read More

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Corneal Cross-linking as an Adjunct for The Management of Refractory Fungal Keratitis.

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):204-209. Epub 2021 Jan 19.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To evaluate the effectiveness of ultraviolet (UV)-A/Riboflavin corneal cross-linking (CXL) for the treatment of the refractory cases of fungal keratitis.

Methods: In this prospective interventional study, 9 patients with the diagnosis of fungal keratitis that were referred to our emergency eye center were included. These patients were resistant to conventional treatment and underwent therapeutic UV-A/Riboflavin CXL. Read More

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Safety and efficacy of UV application for superficial infections in humans: A systematic review and meta-analysis.

Ocul Surf 2021 07 31;21:331-344. Epub 2021 Mar 31.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand. Electronic address:

Background: Ultraviolet (UV) light is naturally antimicrobial, but risks associated with UV overexposure have limited its clinical application. This systematic review evaluates the safety and efficacy of UV light treatment of superficial human infections.

Methods: MEDLINE, Embase, Cochrane CENTRAL, ANZCTR and US National Library of Medicine were searched (March 25, 2020). Read More

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Silver Nanoparticles from Oregano Leaves' Extracts as Antimicrobial Components for Non-Infected Hydrogel Contact Lenses.

Int J Mol Sci 2021 Mar 29;22(7). Epub 2021 Mar 29.

Inorganic Chemistry Laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.

The oregano leaves' extract (ORLE) was used for the formation of silver nanoparticles (AgNPs(ORLE)). ORLE and AgNPs(ORLE) (2 mg/mL) were dispersed in polymer hydrogels to give the [email protected]_2 and [email protected](ORLE)_2 using hydroxyethyl-methacrylate (HEMA). The materials were characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), thermogravimetric differential thermal analysis (TG-DTA), derivative thermogravimetry/differential scanning calorimetry (DTG/DSC), ultraviolet (UV-Vis), and attenuated total reflection mode (ATR-FTIR) spectroscopies in solid state and UV-Vis in solution. Read More

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Effect of therapeutic UVC on corneal DNA: Safety assessment for potential keratitis treatment.

Ocul Surf 2021 04 19;20:130-138. Epub 2021 Feb 19.

Ocular Surface Laboratory, Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: Antimicrobial ultraviolet C (UVC) has proven efficacy in vitro against keratitis isolates and has potential to treat corneal infection if safety can be confirmed.

Method: Safety of 265 nm, 1.93 mW/cm intensity UVC (15-300 s exposures) was investigated in vitro via cyclobutane pyrimidine dimer (CPD) formation in DNA of human cultured corneal epithelial cells; ex vivo, by evaluating UVC transmissibility as a function of porcine corneal thickness; and in vivo, by evaluating CPD induction in the mouse cornea following UVC exposure. Read More

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Corneal Cross-linking at the Slit Lamp.

J Refract Surg 2021 Feb;37(2):78-82

Purpose: To describe a new surgical technique where corneal cross-linking (CXL) (to treat corneal ectasias) and photo-activated chromophore for keratitis-CXL (PACK-CXL) are performed while the patient is seated in an upright position at the slit lamp.

Methods: Topical anesthesia is applied in the waiting room, 10 minutes before the procedure. Once in the office or procedure room, eyelids and periorbital areas are disinfected with chloramphenicol and the patient is seated at the slit lamp. Read More

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February 2021

Pathobiology and treatment of viral keratitis.

Exp Eye Res 2021 04 6;205:108483. Epub 2021 Feb 6.

Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address:

Keratitis is one of the most prevalent ocular diseases manifested by partial or total loss of vision. Amongst infectious (viz., microbes including bacteria, fungi, amebae, and viruses) and non-infectious (viz. Read More

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Mass photokeratitis in coronary angiography medical staff following exposure to unprotected ultraviolet light.

J Fr Ophtalmol 2021 May 26;44(5):e317-e318. Epub 2021 Jan 26.

Department of Ophthalmology, Konya Training and Research Hospital, 42250 Konya, Turkey. Electronic address:

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Study on patterned photodynamic cross-linking for keratoconus.

Exp Eye Res 2021 03 23;204:108450. Epub 2021 Jan 23.

Open FIESTA Center, International Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China; Biomanufacturing Engineering Laboratory, International Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China; Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, PR China. Electronic address:

Purpose: This study examined the patterned treatment of corneal collagen cross-linking (CXL) for keratoconus to reduce the complications caused by ultraviolet (UV) irradiation. By modifying the method of UV irradiation during the cross-linking process, cross-linking with a special structure is achieved, and the cross-linking effect is analyzed and compared to that of traditional cross-linking. By constructing an animal model of keratoconus, the process and effect of corneal cross-linking can be investigated more fundamentally. Read More

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Transepithelial Corneal Cross-linking With Supplemental Oxygen in Keratoconus: 1-Year Clinical Results.

J Refract Surg 2021 Jan;37(1):42-48

Purpose: To evaluate the efficacy and safety of transepithelial corneal cross-linking (CXL) with supplemental oxygen.

Methods: This was a prospective, non-comparative, pilot cohort study conducted at the National Reference Center for Keratoconus (Toulouse, France) on patients with progressive keratoconus. Transepithelial, pulsed, accelerated CXL was performed in an oxygen-rich atmosphere. Read More

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January 2021

Corneal Crosslinking to Regress Pathologic Corneal Neovascularization Before High-Risk Keratoplasty.

Cornea 2021 Feb;40(2):147-155

Department of Ophthalmology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.

Purpose: Corneal neovascularization is the main risk factor for graft rejection after high-risk penetrating keratoplasty (PK). Corneal crosslinking (CXL) has been shown to regress pathological corneal blood and lymphatic vessels and to reduce the risk of graft rejection after high-risk PK experimentally in mice. The aim of this work was to analyze whether CXL is also able to regress corneal neovascularization in patients and is a safe procedure in the context of high-risk PK. Read More

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February 2021

Skin and eye protection against ultraviolet C from ultraviolet germicidal irradiation devices during the COVID-19 pandemic.

Int J Dermatol 2021 Apr 1;60(4):391-393. Epub 2020 Dec 1.

Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.

With the COVID-19 pandemic depleting personal protective equipment worldwide, various methods including ultraviolet C (UVC) germicidal irradiation (UVGI) have been implemented to decontaminate N95 filtering facepiece respirators. These devices pose a risk for UVC exposure to the operator with reported adverse effects generally limited to the eyes and skin. Our hospitals are currently using UVC devices for N95 decontamination with a few reported cases of face and neck erythema from exposure. Read More

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