467 results match your criteria Ultraviolet Keratitis

Clinically Compatible Fluorescence Microscopy Based on Moxifloxacin Antibiotic.

Adv Exp Med Biol 2021 ;1310:91-113

Department of Mechanical Engineering, Pohang University of Science and Technology, Pohang, Gyeongbuk, Republic of Korea.

High-resolution fluorescence tissue imaging with the application of moxifloxacin as a cell-labelling agent is described. Moxifloxacin is an antibiotic used in the clinic to both treat and prevent bacterial infections, and it has both good pharmacokinetic properties for tissue penetration and intrinsic fluorescence under ultraviolet (UV) excitation. Alternative usage of moxifloxacin as the cell-labelling agent was discovered and its imaging applications have been explored. Read More

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Corneal Cross-linking as an Adjunct for The Management of Refractory Fungal Keratitis.

Middle East Afr J Ophthalmol 2020 Oct-Dec;27(4):204-209. Epub 2021 Jan 19.

Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Purpose: To evaluate the effectiveness of ultraviolet (UV)-A/Riboflavin corneal cross-linking (CXL) for the treatment of the refractory cases of fungal keratitis.

Methods: In this prospective interventional study, 9 patients with the diagnosis of fungal keratitis that were referred to our emergency eye center were included. These patients were resistant to conventional treatment and underwent therapeutic UV-A/Riboflavin CXL. Read More

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January 2021

Safety and efficacy of UV application for superficial infections in humans: A systematic review and meta-analysis.

Ocul Surf 2021 Mar 31. Epub 2021 Mar 31.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, Auckland, New Zealand. Electronic address:

Background: Ultraviolet (UV) light is naturally antimicrobial, but risks associated with UV overexposure have limited its clinical application. This systematic review evaluates the safety and efficacy of UV light treatment of superficial human infections.

Methods: MEDLINE, Embase, Cochrane CENTRAL, ANZCTR and US National Library of Medicine were searched (March 25, 2020). Read More

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Silver Nanoparticles from Oregano Leaves' Extracts as Antimicrobial Components for Non-Infected Hydrogel Contact Lenses.

Int J Mol Sci 2021 Mar 29;22(7). Epub 2021 Mar 29.

Inorganic Chemistry Laboratory, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.

The oregano leaves' extract (ORLE) was used for the formation of silver nanoparticles (AgNPs(ORLE)). ORLE and AgNPs(ORLE) (2 mg/mL) were dispersed in polymer hydrogels to give the pHEMA@ORLE_2 and pHEMA@AgNPs(ORLE)_2 using hydroxyethyl-methacrylate (HEMA). The materials were characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), thermogravimetric differential thermal analysis (TG-DTA), derivative thermogravimetry/differential scanning calorimetry (DTG/DSC), ultraviolet (UV-Vis), and attenuated total reflection mode (ATR-FTIR) spectroscopies in solid state and UV-Vis in solution. Read More

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Effect of therapeutic UVC on corneal DNA: Safety assessment for potential keratitis treatment.

Ocul Surf 2021 Apr 19;20:130-138. Epub 2021 Feb 19.

Ocular Surface Laboratory, Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand. Electronic address:

Purpose: Antimicrobial ultraviolet C (UVC) has proven efficacy in vitro against keratitis isolates and has potential to treat corneal infection if safety can be confirmed.

Method: Safety of 265 nm, 1.93 mW/cm intensity UVC (15-300 s exposures) was investigated in vitro via cyclobutane pyrimidine dimer (CPD) formation in DNA of human cultured corneal epithelial cells; ex vivo, by evaluating UVC transmissibility as a function of porcine corneal thickness; and in vivo, by evaluating CPD induction in the mouse cornea following UVC exposure. Read More

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Corneal Cross-linking at the Slit Lamp.

J Refract Surg 2021 Feb;37(2):78-82

Purpose: To describe a new surgical technique where corneal cross-linking (CXL) (to treat corneal ectasias) and photo-activated chromophore for keratitis-CXL (PACK-CXL) are performed while the patient is seated in an upright position at the slit lamp.

Methods: Topical anesthesia is applied in the waiting room, 10 minutes before the procedure. Once in the office or procedure room, eyelids and periorbital areas are disinfected with chloramphenicol and the patient is seated at the slit lamp. Read More

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February 2021

Pathobiology and treatment of viral keratitis.

Exp Eye Res 2021 Apr 6;205:108483. Epub 2021 Feb 6.

Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL, 60612, USA. Electronic address:

Keratitis is one of the most prevalent ocular diseases manifested by partial or total loss of vision. Amongst infectious (viz., microbes including bacteria, fungi, amebae, and viruses) and non-infectious (viz. Read More

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Study on patterned photodynamic cross-linking for keratoconus.

Exp Eye Res 2021 Mar 23;204:108450. Epub 2021 Jan 23.

Open FIESTA Center, International Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China; Biomanufacturing Engineering Laboratory, International Graduate School at Shenzhen, Tsinghua University, Shenzhen, 518055, PR China; Department of Mechanical Engineering, Biomanufacturing Center, Tsinghua University, Beijing, PR China. Electronic address:

Purpose: This study examined the patterned treatment of corneal collagen cross-linking (CXL) for keratoconus to reduce the complications caused by ultraviolet (UV) irradiation. By modifying the method of UV irradiation during the cross-linking process, cross-linking with a special structure is achieved, and the cross-linking effect is analyzed and compared to that of traditional cross-linking. By constructing an animal model of keratoconus, the process and effect of corneal cross-linking can be investigated more fundamentally. Read More

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Skin and eye protection against ultraviolet C from ultraviolet germicidal irradiation devices during the COVID-19 pandemic.

Int J Dermatol 2021 Apr 1;60(4):391-393. Epub 2020 Dec 1.

Department of Dermatology, Henry Ford Health System, Detroit, MI, USA.

With the COVID-19 pandemic depleting personal protective equipment worldwide, various methods including ultraviolet C (UVC) germicidal irradiation (UVGI) have been implemented to decontaminate N95 filtering facepiece respirators. These devices pose a risk for UVC exposure to the operator with reported adverse effects generally limited to the eyes and skin. Our hospitals are currently using UVC devices for N95 decontamination with a few reported cases of face and neck erythema from exposure. Read More

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UV-Photokeratitis Associated with Germicidal Lamps Purchased during the COVID-19 Pandemic.

Ocul Immunol Inflamm 2021 Jan 20;29(1):76-80. Epub 2020 Nov 20.

Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Purpose: To report photokeratitis caused by the improper use of germicidal lamps purchased during the COVID-19 pandemic.

Methods: Case series.

Results: Seven patients presented with acute ocular surface pain after exposure to UV-emitting germicidal lamps. Read More

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January 2021

Green biosynthesis of silver nanoparticles by Aspergillus niger and its antiamoebic effect against Allovahlkampfia spelaea trophozoite and cyst.

Exp Parasitol 2020 Dec 19;219:108031. Epub 2020 Oct 19.

Department of Parasitology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Fungi represent an interesting candidate for the synthesis of nanoparticles. The biosynthesis of silver nanoparticles (AgNPs) has many industrial and biomedical indications. We aimed in this work to biologically synthesize silver nanoparticles using Aspergillus niger and to evaluate its effect against the newly identified Allovahlkampfia spelaea that causes resistant human keratitis. Read More

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December 2020

[Application of visible longwave radiation for inactivation of microorganisms].

Vestn Oftalmol 2020 ;136(6):42-49

Research Institute of Eye Diseases, Moscow, Russia.

Purpose: To perform a comparative assessment of the bactericidal and fungicidal effects of various parts of the radiation spectrum (Ultraviolet A, red, green and blue).

Material And Methods: The study included strains of the most clinically significant microorganisms, which are the most common causes of purulent keratitis - , and fungi . After populating the surface of Petri dishes uniformly with microorganisms of each culture, on four out of the five specimens the central zone of the surface with a diameter of 1 cm was irradiated with light of different spectrum - from ultraviolet to red, with a total radiation energy density of 5. Read More

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October 2020

[Keratoconjunctivitis photoelectrica (arc eye)].

Pan Afr Med J 2020 27;36:42. Epub 2020 May 27.

Service d'Ophtalmologie, Hôpital Militaire d'Instruction Mohammed V, Faculté de Médecine et de Pharmacie, Université Mohammed V, Rabat, Maroc.

Photokeratitis is a painful keratitis caused by exposure of insufficiently protected eyes to the ultraviolet (UV) rays. We talk about "arc eye" when photokeratitis is caused by UV rays emitted by electric arc during electric arc welding process. We here report the case of a 35-year old rider, with no previous medical-surgical history, who had looked at an electric arc for a few minutes while the doors of his building were welded. Read More

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December 2020

Protective Effect of Vitamin C against Infancy Rat Corneal Injury Caused by Acute UVB Irradiation.

Biomed Res Int 2020 25;2020:8089273. Epub 2020 May 25.

Graduate School, Fourth Military Medical University, Xi'an, Shaanxi Province 710032, China.

Purpose: Studies have shown that corneas of young children were more susceptible to Ultraviolet B (UVB) radiation damage. However, there exist limited information about the harm of UVB to eyes and preventive measures on infancy. Vitamin C as an antioxidant is widely used to prevent many diseases. Read More

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Corneal collagen cross-linking for bacterial infectious keratitis.

Cochrane Database Syst Rev 2020 06 17;6:CD013001. Epub 2020 Jun 17.

General Clinical Research Center, Howard University, Washington, DC, USA.

Background: Infectious keratitis is an infection of the cornea that can be caused by bacteria, viruses, fungi, protozoa, or parasites. It may be associated with ocular surgery, trauma, contact lens wear, or conditions that cause deficiency or loss of corneal sensation, or suppression of the immune system, such as diabetes, chronic use of topical steroids, or immunomodulatory therapies. Photoactivated chromophore for collagen cross-linking (PACK-CXL) of the cornea is a therapy that has been successful in treating eye conditions such as keratoconus and corneal ectasia. Read More

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Early treatment of bilateral fungal keratitis with corneal cross-linking as adjuvant therapy.

Oxf Med Case Reports 2020 Jun 13;2020(6):omaa032. Epub 2020 Jun 13.

Instituto de la Visión Cerro de las Rosas, Sanatorio Allende - Sede Cerro, Córdoba X5009CGE, Argentina.

Fungal keratitis is an ocular infection that has no standardized treatment. The etiological agents most frequently reported in the literature are spp., spp. Read More

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Metformin-coated silver nanoparticles exhibit anti-acanthamoebic activities against both trophozoite and cyst stages.

Exp Parasitol 2020 Aug 24;215:107915. Epub 2020 May 24.

Department of Biology, Chemistry and Environmental Sciences, College of Arts and Sciences, American University of Sharjah, Sharjah, 26666, United Arab Emirates.

Acanthamoeba castellanii is an opportunistic protozoan responsible for serious human infections including Acanthamoeba keratitis and granulomatous amoebic encephalitis. Despite advances in antimicrobial therapy and supportive care, infections due to Acanthamoeba are a major public concern. Current methods of treatment are not fully effective against both the trophozoite and cyst forms of A. Read More

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Accelerated Corneal Cross-linking as an Adjunct Therapy in the Management of Presumed Bacterial Keratitis: A Cohort Study.

J Refract Surg 2020 Apr;36(4):258-264

Purpose: To compare the outcomes of accelerated photoactivated chromophore for keratitis corneal cross-linking (PACK-CXL) as an adjunct treatment for bacterial keratitis (PACK-CXL plus standard antibiotic therapy) for patients receiving only standard antibiotic therapy.

Methods: Retrospective cohort study of outcomes of patients with moderate infectious presumed bacterial keratitis (ulcer diameter 2 to 7 mm and stromal depth < 300 µm) were compared before and after initiation of a new treatment protocol of PACK-CXL in addition to standard antibiotic treatment.

Results: A total of 70 eyes of 70 patients were included: 39 eyes in the PACK-CXL plus antibiotic (PACK-ABX) group and 31 eyes in the antibiotic only (ABX) control group. Read More

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Corneal Cross-Linking (CXL) for Therapy-Resistant Keratitis with Corneal Melting: It Is Never Too Late!

Klin Monbl Augenheilkd 2020 Apr 4;237(4):419-422. Epub 2020 Mar 4.

Department of Ophthalmology, Universitätsspital Basel Augenklinik, University of Basel, Basel, Switzerland.

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Role of Matrix Metalloproteinase 9 in Ocular Surface Disorders.

Eye Contact Lens 2020 Mar;46 Suppl 2:S57-S63

Department of Ophthalmology (E.C.J.), Columbia University Medical Center, New York, NY; Bascom Palmer Eye Institute (A.M.E., T.K.E.), University of Miami Miller School of Medicine, Miami, FL; Department of Ophthalmology (A.M.E., R.H.E., Y.M.E.S.), Kasr Al-Ainy, Cairo University, Giza, Egypt; and Department of Ophthalmology (T.K.E.), Faculty of Medicine, Benha University, Benha, Egypt.

Objectives: (1) To explore the role and significance of Matrix Metalloproteinase 9 (MMP-9), a proteolytic enzyme, in various ocular surface diseases of inflammatory, infectious, and traumatic etiology (2), to further elucidate the molecular mechanisms responsible for its overexpression in ocular surface disease states, and (3) to discuss possible targets of therapeutic intervention.

Methods: A literature review was conducted of primary sources from 1995 onward using search results populated from the US National Library of Medicine search database.

Results: MMP-9 overexpression has been found in in vitro and in vivo models of dry eye disease (DED), corneal ulceration, microbial keratitis, corneal neovascularization, ultraviolet light-induced radiation, and a host of additional surface pathologies. Read More

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Antiamoebic activity of plant-based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492).

AMB Express 2020 Feb 3;10(1):24. Epub 2020 Feb 3.

Department of Biology, Chemistry and Environmental Sciences, American University of Sharjah, Sharjah, 26666, United Arab Emirates.

Acanthamoeba spp. are the causative agent of Acanthamoeba keratitis and granulomatous amoebic encephalitis (GAE). The current options to treat Acanthamoeba infections have limited success. Read More

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February 2020

Nightclub Photokeratitis.

Ophthalmology 2020 02;127(2):239

Department of Ophthalmology, Government Medical College and Hospital, Panjab University, Chandigarh, India.

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February 2020

Rose bengal photodynamic antimicrobial therapy to inhibit Pseudomonas aeruginosa keratitis isolates.

Lasers Med Sci 2020 Jun 23;35(4):861-866. Epub 2019 Dec 23.

Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, 1638 NW 10th Avenue, #117A, Miami, FL, 33136, USA.

To evaluate the in vitro efficacy of rose bengal and riboflavin photodynamic antimicrobial therapy for inhibition the growth of four Pseudomonas aeruginosa (P. aeruginosa) isolates. Four different clinical P. Read More

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Corneal Collagen Cross-Linking With Photoactivated Chromophore for Infectious Keratitis After Penetrating Keratoplasty.

Cornea 2020 Mar;39(3):283-289

Department of Ophthalmology, Ankara Training and Research Hospital, University of Health Sciences, Ankara, Turkey.

Purpose: To evaluate the efficacy and safety of corneal collagen cross-linking with photoactivated chromophore (PACK-CXL) plus medical treatment in comparison with the non-CXL group in the management of graft infections after penetrating keratoplasty.

Methods: Forty eyes of 40 patients, 18 eyes in the PACK-CXL group and 22 eyes in the non-CXL group, with graft infections were retrospectively reviewed. Patients with microbial keratitis who were resistant to medical treatment for at least 1 week were treated with PACK-CXL in conjunction with medical treatment. Read More

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Cross-Linking-Assisted Infection Reduction: A Randomized Clinical Trial Evaluating the Effect of Adjuvant Cross-Linking on Outcomes in Fungal Keratitis.

Ophthalmology 2020 02 4;127(2):159-166. Epub 2019 Sep 4.

Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, California; UCSF Department of Ophthalmology, University of California, San Francisco, San Francisco, California; The Permanente Medical Group, Redwood City, California. Electronic address:

Purpose: To determine if there is a benefit to adjuvant corneal crosslinking (CXL) and to compare natamycin versus amphotericin B for filamentous fungal keratitis.

Design: Outcome-masked, 2×2 factorial design, randomized controlled clinical trial.

Participants: Consecutive patients presenting with moderate vision loss from a smear-positive fungal ulcer at Aravind Eye Hospital, Madurai, India. Read More

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February 2020

Bilateral viral keratitis following corneal collagen crosslinking for progressive keratoconus.

J Ophthalmic Inflamm Infect 2019 Aug 28;9(1):16. Epub 2019 Aug 28.

Geta Eye Hospital, Kailali, Nepal.

Purpose: Corneal collagen crosslinking has been proven to be a useful technique to slow the progression of keratoconus. With its increasing use, we are encountering rare complications. We describe a case that developed bilateral viral keratitis after corneal collagen crosslinking with riboflavin and ultraviolet A for progressive keratoconus. Read More

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Efficacy of Chlorhexidine and a riboflavin/UVA Combination on Fungal Agents of Keratitis.

Curr Eye Res 2020 01 14;45(1):7-11. Epub 2019 Aug 14.

Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Cukurova, Adana, Turkey.

: Mycotic keratitis is a global ophthalmological problem because it is difficult to diagnose and treat. The aim of the current study was to evaluate the efficiency of using antifungal agents amphotericin B (AMB), voriconazole (VRC), 0.02% chlorhexidine (CHX), and a combination of riboflavin and UVA treatment against two fungal genera ( and ) responsible for keratitis. Read More

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January 2020

Real-world experience of dupilumab treatment for atopic dermatitis in adults: a retrospective analysis of patients' records.

Int J Dermatol 2020 Feb 8;59(2):253-256. Epub 2019 Jul 8.

Department of Dermatology, University of California, Irvine, California, USA.

Background: Clinical trial data for dupilumab, a monoclonal antibody against the interleukin-4 receptor (IL-4Rα), have shown that it is safe and effective for the treatment of moderate to severe atopic dermatitis in patients whose disease is resistant to other therapies. However, little real-world experience with dupilumab use has been reported thus far. The aim of this retrospective study was to assess overall outcomes in adult patients with atopic dermatitis (AD) treated with dupilumab. Read More

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February 2020

Microsporidial keratitis retrospectively diagnosed by ultrastructural study of formalin-fixed paraffin-embedded corneal tissue: a case report.

Ann Clin Microbiol Antimicrob 2019 Jun 10;18(1):17. Epub 2019 Jun 10.

Department of Ophthalmology, Kindai University Faculty of Medicine, 377-2, Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan.

Background: The utility of formalin-fixed paraffin-embedded (FFPE) corneal tissue specimens for retrospective diagnosis of microsporidial keratitis was evaluated by transmission electron microscopy (TEM) analysis and the possible second case of microsporidial keratitis after Descemet stripping automated endothelial keratoplasty (DSAEK) was described.

Case Presentation: A 68-year-old man presented with multiple crystalline opacities in the corneal stroma that progressed extremely slowly after DSAEK. Fungiflora Y staining of corneal scrapings from the affected regions revealed an oval microorganism. Read More

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