426 results match your criteria Ultraviolet Keratitis


Evaluation of acute corneal damage induced by 222-nm and 254-nm ultraviolet light in Sprague-Dawley rats.

Free Radic Res 2019 Apr 5:1-151. Epub 2019 Apr 5.

a Department of Ophthalmology , Faculty of Medicine , Shimane University , Izumo , Japan.

Two hundred twenty-two nanometers ultraviolet (UV) light produced by a krypton-chlorine excimer lamp is harmful to bacterial cells but not skin. However, the effects of 222-nm UV light exposure to the eye are not fully known. We evaluated acute corneal damage induced by 222- and 254-nm UV light in albino rats. Read More

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https://www.tandfonline.com/doi/full/10.1080/10715762.2019.1
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http://dx.doi.org/10.1080/10715762.2019.1603378DOI Listing
April 2019
3 Reads

Protective Effects of Fucoxanthin on Ultraviolet B-Induced Corneal Denervation and Inflammatory Pain in a Rat Model.

Mar Drugs 2019 Mar 5;17(3). Epub 2019 Mar 5.

Department of Medicine, Mackay Medical College, New Taipei 25245, Taiwan.

Fucoxanthin is a carotenoid with many pharmaceutical properties that is found in brown seaweed. However, the effects of fucoxanthin on corneal innervation and intense eye pain have not been extensively examined. To clarify the protective roles and underlying mechanisms of fucoxanthin on ocular lesions, we investigated the beneficial effects and mechanisms by which fucoxanthin ameliorates ultraviolet B (UVB)-induced corneal denervation and trigeminal pain. Read More

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http://dx.doi.org/10.3390/md17030152DOI Listing
March 2019
1 Read

[Inflammatory metabolites of arahidonic acid in tear fluid in UV-induced corneal damage].

Biomed Khim 2019 Jan;65(1):33-40

Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russia; Sechenov First Moscow State Medical University, Institute of Molecular Medicine, Moscow, Russia.

The ultraviolet (UV) B-induced damage of the eye surface of experimental animals (rabbits) includes loss of corneal epithelium, apoptosis of keratocytes and stromal edema. These changes are accompanied by clinically and histologically manifested corneal inflammation, neutrophil infiltration, and exudation of the anterior chamber of the eye. According to mass spectrometric analysis, UV-induced corneal damage is associated with pronounced changes in the lipid composition of tears, including a decrease in the amount of arachidonic acid and prostaglandin E2 and an increase in the concentrations of prostaglandin D2 and its derivative 15d-PGJ2. Read More

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http://dx.doi.org/10.18097/PBMC20196501033DOI Listing
January 2019
2 Reads

Highly invasive and poorly differentiated corneal squamous cell carcinoma in a dog.

BMC Vet Res 2019 Feb 7;15(1):52. Epub 2019 Feb 7.

Departamento de Producción y Sanidad Animal, Salud Pública Veterinaria y Ciencia y Tecnología de los alimentos, Unidad de Histología y Anatomía Patológica, Facultad de Veterinaria, Universidad Cardenal Herrera-CEU, CEU Universities, Tirant lo Blanc, 7, 46115, Alfara del Patriarca, Valencia, Spain.

Background: Primary corneal tumors are unusual in dogs although there has been a rise in the prevalence of canine corneal squamous cell carcinoma in the past decades due to different factors. Exposure to ultraviolet radiation, presence of chronic keratitis or history of superficial trauma are some of them. We report for the first time a highly infiltrative corneal neoplasia with both exophytic and deep stromal growth, which presented atypical histologic features of a squamous cell carcinoma. Read More

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http://dx.doi.org/10.1186/s12917-019-1790-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367762PMC
February 2019
1 Read

Prospective study of the sensitivity of the Wood's lamp for common eye abnormalities.

Emerg Med J 2019 Mar 10;36(3):159-162. Epub 2019 Jan 10.

Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

Objective: The Wood's lamp, a handheld instrument that uses long-wave ultraviolet (UV) light with magnification of 2-3 times, is commonly used by non-ophthalmologists for examining patients with eye complaints. The goal of current research was to determine the sensitivity and specificity of the Wood's lamp for common eye abnormalities.

Study Design: We examined a convenience sample of patients, 18 years of age and older, who presented for eye complaints to an urgent clinic of a large ophthalmology practice. Read More

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http://dx.doi.org/10.1136/emermed-2018-208235DOI Listing
March 2019
1 Read

Late-Onset Sterile Peripheral Ulcerative Keratitis Post-Corneal Collagen Crosslinking.

Cornea 2019 Mar;38(3):338-343

Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon.

Purpose: To report the incidence, characteristics, clinical presentations, risk factors, and the available treatment modalities of sterile peripheral ulcerative keratitis (PUK) post-corneal collagen crosslinking (CXL).

Methods: This study is a retrospective study including 771 eyes of 474 patients operated for keratoconus or ectasia after LASIK between January 2010 and June 2017 at Beirut Eye & ENT Specialist hospital. The average follow-up period was 4. Read More

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http://Insights.ovid.com/crossref?an=00003226-201903000-0001
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http://dx.doi.org/10.1097/ICO.0000000000001842DOI Listing
March 2019
2 Reads

[Therapeutic efficacy of ultraviolet combined with riboflavin for the rabbit bacterial keratitis].

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):902-910

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing 100005, China.

To study the effects of ultraviolet light combined with riboflavin treatment (corneal collagen-crosslinking, CXL) on infectious control and stromal reconstruction of bacterial keratitis. Experimental Study. A Staphylococcus aureus rabbit keratitis model was established by injecting Staphylococcus aureus broth into the shallow stromal layer of the right eye cornea of New Zealand white rabbits. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2018.12.007DOI Listing
December 2018
2 Reads

In Vitro Amoebicidal Activity of Titanium Dioxide/UV-A Combination Against Acanthamoeba.

Invest Ophthalmol Vis Sci 2018 09;59(11):4567-4571

Service d'Ophtalmologie, Hôpitaux Universitaires de Strasbourg, Nouvel Hôpital Civil, Strasbourg, France.

Purpose: To assess the amoebicidal effect of titanium dioxide (TiO2)/UV-A combination against Acanthamoeba sp trophozoites and cysts.

Methods: The amoebicidal effect of the TiO2/UV-A combination was tested on trophozoites and cysts of clinical isolates of Acanthamoeba hatchetti and Acanthamoeba sp genotype T4, obtained from two severe cases of ulcerative keratitis. Samples of cultured Acanthamoeba were transferred to a 96-well plate. Read More

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http://dx.doi.org/10.1167/iovs.18-25003DOI Listing
September 2018
14 Reads

Impact of Iontophoresis and PACK-CXL Corneal Concentrations of Antifungals in an In Vivo Model.

Cornea 2018 Nov;37(11):1463-1467

Department of Ophthalmology, Gazi University Faculty of Medicine, Ankara, Turkey.

Purpose: To investigate voriconazole (VRZ) penetration and fungal load in the cornea after applying VRZ therapy with various treatment combinations in a fungal keratitis model.

Methods: Fifty-four eyes of 27 young albino rabbits were provided for this experimental study. Twelve corneas were inoculated with Candida albicans, 12 corneas were inoculated with Fusarium solani, and 6 eyes were selected as controls. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001696DOI Listing
November 2018
9 Reads

A Review of Corneal Collagen Cross-linking - Current Trends in Practice Applications.

Open Ophthalmol J 2018 23;12:181-213. Epub 2018 Jul 23.

Undergraduate medical student, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Objective: To review the literature on current applications of corneal Collagen Cross-Linking (CXL).

Methods: A review of publications on corneal cross-linking was conducted. This included systemic reviews, randomized controlled clinical trials, cohort studies, case-controlled studies and case series. Read More

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http://dx.doi.org/10.2174/1874364101812010181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6062907PMC
July 2018
38 Reads

Does PACK-CXL Change the Prognosis of Resistant Infectious Keratitis?

J Refract Surg 2018 Aug;34(8):559-563

Purpose: To examine the clinical characteristics, treatments, and prognosis of all cases of infectious keratitis resistant to conventional therapy and treated by photo-activated chromophore for keratitis corneal cross-linking (PACK-CXL) in one institution between 2012 and 2016.

Methods: A database search of patients who underwent PACK-CXL (ultraviolet-A for 10 minutes for irradiance of 9 mW/cm) for infectious keratitis unresponsive to medical treatment at a tertiary care hospital was conducted. The following parameters were documented: patient demographic information, corrected distance visual acuity (CDVA) before the procedure and at the end of follow-up, characteristics of the ulcer, antibiotic treatment prior to CXL, culture results, and long-term complications. Read More

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http://dx.doi.org/10.3928/1081597X-20180705-01DOI Listing
August 2018
6 Reads

Corneal Cross-Linking: Current USA Status: Report From the Cornea Society.

Cornea 2018 Oct;37(10):1218-1225

Department of Ophthalmology, University of Brest, Brest, France.

The initial published clinical report on riboflavin/ultraviolet A corneal cross-linking (CXL) for treatment of progressive keratoconus dates back to 2003. CXL has since then been widely used outside the United States for treatment of progressive keratoconus and post-laser in situ keratomileusis ectasia. The Food and Drug Administration (FDA) approved Avedro Inc. Read More

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http://Insights.ovid.com/crossref?an=00003226-201810000-0000
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http://dx.doi.org/10.1097/ICO.0000000000001707DOI Listing
October 2018
17 Reads
2.360 Impact Factor

Effect of Riboflavin/Rose Bengal-Mediated PACK-CXL on Acanthamoeba Trophozoites and Cysts in Vitro.

Curr Eye Res 2018 Nov 7;43(11):1322-1325. Epub 2018 Aug 7.

a Department of Ophthalmology, School of Medicine , Gazi University , Ankara , Turkey.

Purpose: To evaluate the antiamoebic properties of photo-activated chromophore for keratitis (PACK)-corneal cross-linking (CXL) (PACK-CXL), in combination with riboflavin (0.1 and 0.25%) or rose bengal (0. Read More

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http://dx.doi.org/10.1080/02713683.2018.1501074DOI Listing
November 2018
30 Reads
1.663 Impact Factor

Evaluation of the Effectiveness of Cross-Linking Combined With Photorefractive Keratectomy for Treatment of Keratoconus.

Cornea 2018 Sep;37(9):1143-1150

Department of Ophthalmology, Faculty of Medicine, Sohag University, Sohag, Egypt.

Purpose: To evaluate the effectiveness and safety of combined epithelium-off cross-linking (CXL) with photorefractive keratectomy (CXL Plus) for correction of the myopic and astigmatic components of keratoconus.

Methods: Seventy-nine eyes of 46 patients who underwent CXL Plus were enrolled in this retrospective, multicenter, noncomparative clinical study. Uncorrected distance visual acuity, corrected distance visual acuity, refraction, keratometry, and pachymetry measurements were recorded preoperatively and at 3, 6, 12, and 18 months during follow-up. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6092093PMC
September 2018
6 Reads
2.360 Impact Factor

Antarctica eye study: a prospective study of the effects of overwintering on ocular parameters and visual function.

BMC Ophthalmol 2018 Jun 25;18(1):149. Epub 2018 Jun 25.

Clinical Research Department, International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: In 2013 five polar explorers attempted to complete the first Trans-Antarctic Winter Traverse (TAWT). This study presents the ophthalmological findings for this group, who overwintered in Antarctica as part of the White Mars Human Science Protocol. Antarctic crews are exposed to extreme cold, chronic hypoxia and altered day-night cycles. Read More

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http://dx.doi.org/10.1186/s12886-018-0816-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6019514PMC
June 2018
7 Reads

PACK-CXL in Reducing the Time to Heal in Suppurative Corneal Ulcers: Observations of a Pilot Study From South India.

Cornea 2018 Nov;37(11):1376-1380

Department of Ophthalmology, Christian Medical College, Vellore, Tamil Nadu, India. Priya Basaiawmoit is now with The Eye Foundation Tirupur, Tamil Nadu, India.

Purpose: To assess the usefulness of photoactivated chromophore for infectious keratitis-corneal collagen cross-linking in reducing the time to heal in suppurative corneal ulcers in a South Indian tertiary care center.

Methods: This was an observational cohort study with 2 arms. In the prospective arm, 13 patients with suppurative corneal ulcers who presented to the outpatient department were recruited. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001667DOI Listing
November 2018
4 Reads

Comparison of corneal collagen cross-linking (PACK-CXL) and voriconazole treatments in experimental fungal keratitis.

Acta Ophthalmol 2019 Feb 4;97(1):e91-e96. Epub 2018 Jun 4.

Department of Medical Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey.

Purpose: To compare the antifungal efficacy of corneal collagen cross-linking with photoactivated riboflavin (PACK-CXL) and voriconazole in experimental Fusarium solani and Candida albicans keratitis models.

Methods: Sixty-four corneas of 32 New Zealand rabbits were included and divided into two main groups. Intrastromal injection of Fusarium and Candida suspensions was performed, and it was observed that keratitis was formed on the third day. Read More

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http://doi.wiley.com/10.1111/aos.13829
Publisher Site
http://dx.doi.org/10.1111/aos.13829DOI Listing
February 2019
10 Reads

Corneal Subbasal Nerve Recovery in an Acute Case of Ultraviolet Keratitis Treated with Autologous Serum Eye Drops.

J Ophthalmol 2018 26;2018:4905487. Epub 2018 Feb 26.

Ocular Surface Imaging Center, Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.

Purpose: To report degeneration of subbasal corneal nerves and the subsequent neuroregeneration in a case of acute ultraviolet (UV) keratitis, treated with autologous serum eye drops.

Methods: Case report.

Results: A 37-year-old female presented with ocular discomfort and blurred vision in both eyes, after exposure to UV-C light in a laboratory. Read More

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http://dx.doi.org/10.1155/2018/4905487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5846376PMC
February 2018

Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis.

BMC Ophthalmol 2018 Mar 2;18(1):65. Epub 2018 Mar 2.

People's Hospital of Zhengzhou University and Henan Provincial People's Hospital, Henan Eye Institute, Henan Eye Hospital, Zhengzhou, 450003, China.

Background: Fungal keratitis is one of the major causes of visual impairment worldwide. However, the effectiveness of corneal collagen cross-linking (CXL) for fungal keratitis remains controversial. In this study, we developed an in vitro and an in vivo models to assess the efficacy of CXL for Fusarium keratitis. Read More

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http://dx.doi.org/10.1186/s12886-018-0727-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5833033PMC
March 2018
29 Reads

Corneal Collagen Cross-Linking for the Management of Mycotic Keratitis.

Mycopathologia 2018 Jun 16;183(3):521-527. Epub 2018 Feb 16.

Department of Ophthalmology, School of Medicine, Cukurova University, 01330, Adana, Turkey.

Purpose: To evaluate the efficiency of corneal collagen cross-linking (CXL) in addition to topical voriconazole in cases with mycotic keratitis.

Design: Retrospective case series in a tertiary university hospital.

Participants: CXL was performed on 13 patients with mycotic keratitis who presented poor or no response to topical voriconazole treatment. Read More

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http://dx.doi.org/10.1007/s11046-018-0247-8DOI Listing
June 2018
6 Reads

[Corneal collagen cross-linking in the treatment of infectious keratitis and corneal ulcers].

Vestn Oftalmol 2017;133(6):113-119

Research Institute of Eye Diseases, 11 A, B, Rossolimo St., Moscow, Russian Federation, 119021.

In recent years, collagen cross-linking (CXL) of the cornea has acquired a new usage - in the treatment of infectious keratitis and corneal ulcers. This review was aimed at compiling the previously published data and assessing the effectiveness of the method. Read More

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http://dx.doi.org/10.17116/oftalma20171336113-118DOI Listing
April 2018
5 Reads

Collagen Cross-Linking in the Management of Microbial Keratitis.

Ocul Immunol Inflamm 2018 Jan 8:1-6. Epub 2018 Jan 8.

a Clinica Oculistica, Di.N.O.G.M.I. University of Genoa and Ospedale Policlinico San Martino , Genoa , Italy.

Increasing resistance to antimicrobial agents has contributed to an elevated risk of complications of infectious keratitis. Corneal collagen cross-linking (CXL) has been widely adopted for the management of keratoconus and post-refractive surgery corneal ectasia. It has recently been introduced as an option for treating keratitis due to multidrug resistant organisms. Read More

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http://dx.doi.org/10.1080/09273948.2017.1414856DOI Listing
January 2018
4 Reads

Accelerated Corneal Cross-Linking With Photoactivated Chromophore for Moderate Therapy-Resistant Infectious Keratitis.

Cornea 2018 Apr;37(4):528-531

Center for Applied Biotechnology and Molecular Medicine (CABMM), University of Zurich, Zurich, Switzerland.

Purpose: To evaluate the effect of accelerated corneal cross-linking with photoactivated chromophore (PACK-CXL) as additional treatment for therapy-resistant infectious keratitis.

Methods: In this interventional cohort study, 20 patients (11 men and 9 women), aged 65.5 (interquartile range = 21. Read More

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http://dx.doi.org/10.1097/ICO.0000000000001498DOI Listing
April 2018
11 Reads
2.360 Impact Factor

Adherence of Pseudomonas aeruginosa onto surfactant-laden contact lenses.

Colloids Surf B Biointerfaces 2018 Mar 13;163:91-99. Epub 2017 Dec 13.

Drug Discovery, Delivery and Patient Care (DDDPC), School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames, Surrey, KT1 2EE, UK. Electronic address:

There is an immense research interest to utilise contact lens (CLs) as a popular platform for ocular drug delivery. However, CLs are the major predisposing factors of bacterial keratitis which is commonly caused by adhesion of microbes such as Pseudomonas aeruginosa and Staphylococcus epidermidis. The aim of the current study is to explore the effect of surfactants; Poloxamer 188, Polysorbate 80 and Tetronic 90R4 (at 0. Read More

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http://dx.doi.org/10.1016/j.colsurfb.2017.12.024DOI Listing
March 2018
7 Reads

Effect of Ultraviolet Light Irradiation Combined with Riboflavin on Different Bacterial Pathogens from Ocular Surface Infection.

J Biophys 2017 12;2017:3057329. Epub 2017 Oct 12.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University and Beijing Ophthalmology & Visual Sciences Key Laboratory, National Engineering Research Center for Ophthalmology, Beijing 100005, China.

In order to study and viability after the exposure to ultraviolet (UV) light and riboflavin, twelve strains of and twelve strains of were isolated from patients with bacterial keratitis. The growth situation of and under different experimental conditions was qualitatively observed. The number of colonies surviving bacteria was counted under different UV light power and different exposure time. Read More

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http://dx.doi.org/10.1155/2017/3057329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5660810PMC
October 2017
17 Reads

Lack of TNF-α signaling through p55 makes the mice more susceptible to acute infection but does not alter state of latency and reactivation of HSV-1.

Virus Res 2018 01 4;244:1-5. Epub 2017 Nov 4.

Institute of Science, Nirma University, Ahmedabad, Gujarat, India; Medical Virology Section, Laboratory of Clinical Investigation, NIAID, NIH, Bethesda, MD, USA. Electronic address:

TNF-α has been shown to play an important role in pathogenesis and latency of HSV-1 infections. TNF-α signals through TNFR1 (p55) and TNFR2 (p75), and signaling through p55 generally results in gene activation leading to induction of inflammatory responses. Here, we studied the role of TNF-α signaling in latent virus reactivation in p55-knock out (KO) mouse model of ocular HSV-1 infection. Read More

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http://dx.doi.org/10.1016/j.virusres.2017.11.004DOI Listing
January 2018
8 Reads

Danshensu Decreases UVB-Induced Corneal Inflammation in an Experimental Mouse Model via Oral Administration.

Curr Eye Res 2018 01 7;43(1):27-34. Epub 2017 Nov 7.

c Department of Optometry , Chung Shan Medical University , Taichung , Taiwan.

Background: Danshensu is a bioactive constituent of Salvia miltiorrhiza, a plant commonly used in traditional Chinese medicine. In this study, we investigated the pharmacological efficacy of sodium danshensu, or named salvianic acid A sodium (SAS) on ultraviolet B (UVB)-mediated corneal inflammatory injury in mice.

Methods: Albino mice were divided into one blank control group, and three UVB radiation groups, i. Read More

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http://dx.doi.org/10.1080/02713683.2017.1379543DOI Listing
January 2018
4 Reads

Protective Effects of Oral Astaxanthin Nanopowder against Ultraviolet-Induced Photokeratitis in Mice.

Oxid Med Cell Longev 2017 28;2017:1956104. Epub 2017 Sep 28.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose: Astaxanthin (AST) has a strong antioxidant cellular membrane chaperone protective effect. Recently, a water-soluble nanosized AST (nano-AST) form was produced, which is expected to improve the efficacy of oral intake effects. The purpose of this study was to examine whether oral nano-AST has therapeutic effects on UV-induced photokeratitis in mice. Read More

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http://dx.doi.org/10.1155/2017/1956104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637851PMC
July 2018
8 Reads

Photokeratitis induced by ultraviolet radiation in travelers: A major health problem.

J Postgrad Med 2018 Jan-Mar;64(1):40-46

International Travel Medicine Center of Iran, Tehran, Iran.

Ultraviolet (UV) irradiation is one of the several environmental hazards that may cause inflammatory reactions in ocular tissues, especially the cornea. One of the important factors that affect how much ultraviolet radiation (UVR) humans are exposed to is travel. Hence, traveling is considered to include a more acute UVR effect, and ophthalmologists frequently evaluate and manage the ocular manifestations of UV irradiation, including UV-induced keratitis. Read More

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http://dx.doi.org/10.4103/jpgm.JPGM_52_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5820813PMC
October 2017
4 Reads

Corneal Collagen Cross-linking for Treatment of Bacterial and Herpetic Keratitis.

J Clin Diagn Res 2017 Jul 1;11(7):NC12-NC16. Epub 2017 Jul 1.

Ophthalmologist, Department of Ophthalmology, Poostchi Ophthalmology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Fars, Iran.

Introduction: Optimal management of infective keratitis is a formidable challenge and subject of ongoing studies. Recently, Collagen Cross-Linking (CXL) of the cornea has been considered to be a new effective therapeutic approach for resistant infectious keratitis.

Aim: Aim of the study was to evaluate the effectiveness of CXL with Ultraviolet-A (UV-A) and riboflavin for treatment of the refractory bacterial and Herpes Simplex Virus (HSV) keratitis. Read More

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http://dx.doi.org/10.7860/JCDR/2017/24863.10253DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583818PMC
July 2017
4 Reads

In-vitro development of an effective treatment for Acanthamoeba keratitis.

Int J Antimicrob Agents 2017 Sep 12;50(3):325-333. Epub 2017 Jul 12.

Department of Microbiology, Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.

The aim of this study was to develop an in-vitro topical treatment for Acanthamoeba keratitis (AK) effective against cysts and trophozoites. Qualitative assays were performed with voriconazole, chlorhexidine, propamidine, cellulase, tobramycin, ciprofloxacin and paromomycin as monotherapy and various combinations. Riboflavin with ultraviolet-A (R + UV-A) as monotherapy or combined with voriconazole and moxifloxacin was also tested. Read More

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http://dx.doi.org/10.1016/j.ijantimicag.2017.03.033DOI Listing
September 2017
2 Reads

Treatment Results of Corneal Collagen Cross-Linking Combined with Riboflavin and 440 Nm Blue Light for Bacterial Corneal Ulcer in Rabbits.

Curr Eye Res 2017 10 23;42(10):1401-1406. Epub 2017 Jun 23.

a Department of Ophthalmology , Shandong Provincial Hospital Affiliated to Shandong University , Jinan , China.

Purpose: To study the treatment effect of corneal collagen cross-linking (CXL) combined with 440 nm blue light and riboflavin on bacterial corneal ulcer using animal experiments.

Methods: A total of 21 New Zealand white rabbits that developed Staphylococcus aureus corneal ulcer were randomly divided into three groups. Seven rabbits were used as blank control groups; seven rabbits were treated with CXL combined with riboflavin and 440 nm blue light; and seven rabbits were treated with CXL combined with riboflavin and 370 nm ultraviolet A light. Read More

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https://www.tandfonline.com/doi/full/10.1080/02713683.2017.1
Publisher Site
http://dx.doi.org/10.1080/02713683.2017.1332767DOI Listing
October 2017
18 Reads

Corneal Collagen Crosslinking Treatment in a Case with Pneumococcal Keratitis.

Turk J Ophthalmol 2017 Jun 1;47(3):161-164. Epub 2017 Jun 1.

Selçuk University Faculty of Medicine, Department of Ophthalmology, Konya, Turkey.

Bacterial keratitis is a serious ocular infectious disease that can threaten vision. The disease generally progresses rapidly and can lead to corneal scar, stromal abscess formation, perforation, and dissemination to adjacent tissues if not treated properly. Recent studies showed that corneal collagen crosslinking (CCC) using ultraviolet-A/riboflavin is effective in the treatment of bacterial keratitis refractory to topical antibiotic treatment. Read More

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http://dx.doi.org/10.4274/tjo.98470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5468530PMC
June 2017
9 Reads

Collagen Cross-linking for Microbial Keratitis.

Middle East Afr J Ophthalmol 2017 Jan-Mar;24(1):18-23

Tej Kohli Cornea Institute, KVC Campus, L. V. Prasad Eye Institute, Vijayawada, Andhra Pradesh, India.

Collagen cross-linking is gaining popularity not only for arresting the progression of keratoconus but also other indications including management of corneal infections. In this review article, we analyzed the published literature to understand the level of evidence for its use in corneal ulcer. Photoactivated riboflavin and ultraviolet A light are known to possess antimicrobial properties. Read More

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http://dx.doi.org/10.4103/meajo.MEAJO_305_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5433123PMC
June 2017
5 Reads

Collagen Cross-linking With Photoactivated Riboflavin (PACK-CXL) for Bacterial Keratitis After Small Incision Lenticule Extraction (SMILE).

J Refract Surg 2017 Apr;33(4):278-280

Purpose: To report a case of infectious keratitis after small incision lenticule extraction (SMILE) treated with collagen cross-linking with photoactivated riboflavin (PACK-CXL).

Methods: Case report and literature review.

Results: A patient presented with culture-proven bacterial keratitis 5 days after SMILE was treated with fortified topical antibiotics and PACK-CXL. Read More

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http://dx.doi.org/10.3928/1081597X-20170126-01DOI Listing
April 2017
11 Reads

Collagen cross-linking in recalcitrant corneal ulcers: A case series.

Nepal J Ophthalmol 2016 01;8(15):47-53

Introduction: Corneal ulcer is a leading cause of blindness worldwide. Many of these patients don't respond to conventional treatment with topical agents. Collagen cross-linking (CXL) has been suggested to avoid complications requiring emergency keratoplasty. Read More

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http://dx.doi.org/10.3126/nepjoph.v8i1.16156DOI Listing
January 2016
5 Reads

Photochemical eradication of methicillin-resistant Staphylococcus aureus by blue light activation of riboflavin.

Acta Ophthalmol 2017 Aug 15;95(5):498-502. Epub 2017 Feb 15.

Clinical Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Purpose: To compare elimination of methicillin-resistant Staphylococcus aureus (MRSA) by exposure of blue light alone and with riboflavin.

Methods: A reference strain of MRSA was cultured and diluted in PBS with and without riboflavin (0.01%). Read More

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http://dx.doi.org/10.1111/aos.13409DOI Listing
August 2017
14 Reads

Phototoxic Effect of Topical Fluoroquinolones Administered Before Corneal Crosslinking in a Murine Model.

J Ocul Pharmacol Ther 2017 03 20;33(2):73-78. Epub 2017 Jan 20.

3 Department of Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine , Baltimore, Maryland.

Purpose: Corneal crosslinking by UV light (UV-CXL) has become a popular treatment for keratoconus and corneal ectasia. Fluoroquinolones (FQs), commonly administered topically before UV-CXL, are known to be phototoxic to the skin and lens. The purpose of this study was to investigate phototoxic effects of topical FQ treatment on murine corneas before UV-CXL, in which the corneal epithelium was kept intact. Read More

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http://dx.doi.org/10.1089/jop.2016.0060DOI Listing
March 2017
4 Reads

Therapeutic and inducing effect of corneal crosslinking on infectious keratitis.

Int J Ophthalmol 2016 18;9(12):1820-1823. Epub 2016 Dec 18.

Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan 250000, Shandong Province, China.

The corneal crosslinking (CXL) with riboflavin and ultraviolet-A (UVA) is a new therapy method to successfully treat infectious keratitis in clinical practice. However, there are rare reports on the complications of CXL such as the secondary keratitis. The diverse clinical outcomes on keratitis have highlighted the necessity to further evaluate the efficacy and complications of CXL. Read More

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http://dx.doi.org/10.18240/ijo.2016.12.20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154999PMC
December 2016
8 Reads

Photodynamic UVA-riboflavin bacterial elimination in antibiotic-resistant bacteria.

Clin Exp Ophthalmol 2016 Sep 6;44(7):582-586. Epub 2016 Apr 6.

Clinical Research Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Background: To evaluate the bactericidal effect of clinical ultraviolet A (UVA) settings used in photoactivated chromophore for infectious keratitis (PACK)-collagen cross-linking (CXL) in antibiotic-resistant and non-resistant bacterial strains.

Methods: Well-characterized bacterial strains from clinical isolates, without and with antibiotic resistance, were studied in a pairwise comparison. The evaluated pathogens were Staphylococcus epidermidis, Staphylococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis. Read More

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http://dx.doi.org/10.1111/ceo.12723DOI Listing
September 2016
10 Reads

Successful treatment of pityriasis lichenoides chronica with narrow-band ultraviolet B therapy in a patient with Keratitis-Ichthyosis-Deafness syndrome: a case report.

Dermatol Online J 2016 May 15;22(5). Epub 2016 May 15.

Marmara University, School of Medicine, Department of Dermatology, Istanbul.

Keratitis-ichthyosis-deafness (KID) syndrome is a rare genodermatosis causing ichthyosis-like skin lesions, keratitis, and deafness. Herein, we report a patient with this rare syndrome in association with pityriasis lichenoides chronica, which was succesfully treated with narrow-band ultraviolet B phototherapy despite our concerns regarding the increased risk of squamous cell carcinoma, hyperpyrexia, and keratitis. Read More

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May 2016
19 Reads

Pediatric Keratoconus in a Tertiary Referral Center: Incidence, Presentation, Risk Factors, and Treatment.

J Refract Surg 2016 Aug;32(8):534-41

Purpose: To report the incidence, clinical presentation, risk factors, and treatment outcome of pediatric keratoconus in a tertiary referral eye hospital in Beirut, Lebanon.

Methods: In this retrospective study, the authors evaluated all patients with keratoconus 14 years or younger newly diagnosed at the Beirut Eye Specialist Hospital, Beirut, Lebanon, between January 2010 and December 2014. The incidence of pediatric keratoconus among all pediatric patients and among patients with keratoconus of all ages was assessed. Read More

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http://dx.doi.org/10.3928/1081597X-20160513-01DOI Listing
August 2016
7 Reads

Cross-Linking Treatment and Corneal Transplant in Refractory Acremonium Keratitis: Case Report.

Exp Clin Transplant 2016 Oct 23;14(5):580-583. Epub 2015 Nov 23.

From the Department of , Ophthalmology, Ege University Faculty of Medicine, Izmir, Turkey.

Objectives: To report a case of Acremonium keratitis treated with voriconazole, corneal collagen cross-linking, and corneal transplant.

Materials And Methods: Case report.

Results: A 42-year-old woman who wore contact lenses daily was referred for refractory keratitis. Read More

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http://dx.doi.org/10.6002/ect.2014.0187DOI Listing
October 2016
20 Reads

PACK-CXL: Corneal cross-linking in infectious keratitis.

Eye Vis (Lond) 2016 19;3:11. Epub 2016 Apr 19.

Laboratory for Ocular Cell Biology, University of Geneva, Geneva, Switzerland ; Department of Ophthalmology, University of Southern California, Los Angeles, CA USA ; EyeCare Laboratory Research Zurich Associates (ELZA) Institute, Webereistrasse 2, 8953 Dietikon, Switzerland.

Background: Corneal cross-linking (CXL) using ultraviolet light-A (UV-A) and riboflavin is a technique developed in the 1990's to treat corneal ectatic disorders such as keratoconus. It soon became the new gold standard in multiple countries around the world to halt the progression of this disorder, with good long-term outcomes in keratometry reading and visual acuity. The original Dresden treatment protocol was also later on used to stabilize iatrogenic corneal ectasia appearing after laser-assisted in situ keratomileusis (LASIK) and photorefractive keratectomy (PRK). Read More

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http://eandv.biomedcentral.com/articles/10.1186/s40662-016-0
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http://dx.doi.org/10.1186/s40662-016-0042-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836155PMC
April 2016
14 Reads

Current and Future Applications of Photoactivated Chromophore for Keratitis-Corneal Collagen Cross-Linking (PACK-CXL): An Overview of the Different Treatments Proposed.

Semin Ophthalmol 2018 19;33(3):293-299. Epub 2016 Apr 19.

b Vissum Corporacion Oftalmologica , Alicante , Spain.

Purpose: To review the application of the PACK-CXL and to identify different treatment protocols according to the pathogens associated with keratitis.

Methods: A systematic review of 21 articles. The primary outcome was the healing of a corneal ulcer, defined as epithelization, blocking corneal melting. Read More

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http://dx.doi.org/10.3109/08820538.2015.1123731DOI Listing

Cross-linking for microbial keratitis.

Curr Opin Ophthalmol 2016 Jul;27(4):348-52

aDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong bHong Kong Eye Hospital, Mongkok, Kowloon, Hong Kong SAR, China cDr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India dVision Eye Institute, Royal Victorian Eye and Ear Hospital, North West Academic Centre eCentre for Eye Research Australia, University of Melbourne, Melbourne, Victoria, Australia.

Purpose Of Review: Microbial keratitis is one of the leading causes of ocular morbidity. The standard treatment consists of antibiotics, which is intensive and is fraught with risks of antibiotic resistance. Corneal collagen cross-linking (CXL) has recently been advocated as an adjunctive therapy for management of microbial keratitis. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000271DOI Listing
July 2016
11 Reads

Rose Bengal- and Riboflavin-Mediated Photodynamic Therapy to Inhibit Methicillin-Resistant Staphylococcus aureus Keratitis Isolates.

Am J Ophthalmol 2016 Jun 23;166:194-202. Epub 2016 Mar 23.

Ophthalmic Biophysics Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; Anne Bates Leach Eye Hospital, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida; University of Liège, Department of Ophthalmology, CHU Sart-Tillman, Liège, Belgium.

Purpose: To evaluate the in vitro efficacy of rose bengal- and riboflavin-mediated photodynamic therapy for inhibition of methicillin-resistant Staphylococcus aureus (MRSA) isolates.

Design: Experimental study.

Methods: Two different multidrug-resistant, clinical MRSA isolates were grown on nutrient agar, prepared in suspension, and adjusted to concentrations of 1. Read More

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http://dx.doi.org/10.1016/j.ajo.2016.03.014DOI Listing
June 2016
39 Reads

Photokeratitis Linked to Metal Halide Bulbs in Two Gymnasiums - Philadelphia, Pennsylvania, 2011 and 2013.

MMWR Morb Mortal Wkly Rep 2016 Mar 25;65(11):282-5. Epub 2016 Mar 25.

In December 2011 and December 2013, the Philadelphia Department of Public Health (PDPH) received separate reports of clusters of photokeratitis linked to gymnasium events. Photokeratitis, a painful eye condition resulting from unprotected exposure to ultraviolet radiation, has previously been linked to metal halide lamps with broken outer envelopes (1,2). To investigate the cause of these clusters and further characterize patients with photokeratitis, PDPH administered questionnaires to potentially exposed persons, established a case definition, and conducted environmental assessments of both gymnasiums. Read More

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http://dx.doi.org/10.15585/mmwr.mm6511a4DOI Listing
March 2016
9 Reads

Photoactivated Chromophore for Moderate to Severe Infectious Keratitis as an Adjunct Therapy: A Randomized Controlled Trial.

Am J Ophthalmol 2016 May 3;165:94-9. Epub 2016 Mar 3.

Department of Ophthalmology, Faculty of Medicine, Chulalongkorn University, and King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Electronic address:

Purpose: To evaluate the efficacy of photoactivated chromophore for infectious keratitis (PACK-CXL) in the treatment of patients with moderate to severe infectious keratitis as adjunct therapy to the topical medication treatment.

Design: Randomized clinical trial.

Methods: Thirty eyes from 30 patients with moderate to severe infectious keratitis were randomized to receive either standard treatment plus PACK-CXL (n = 15) or standard treatment alone (control group, n = 15). Read More

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http://dx.doi.org/10.1016/j.ajo.2016.02.030DOI Listing
May 2016
9 Reads

Mass photokeratitis following ultraviolet light exposure at a nightclub.

Cont Lens Anterior Eye 2016 Aug 2;39(4):316-7. Epub 2016 Feb 2.

Moorfields Eye Hospital NHS Foundation Trust, 162 City Road, London EC1V 2PD, UK.

Purpose: To report a mass presentation of photokeratitis arising from exposure to an unprotected ultraviolet-B (UV-B) light source.

Results: A cluster of 22 patients presented within a 24-h period to a single eye casualty with symptoms of photokeratitis following recent intense UV-B exposure at a local nightclub. Patients were treated with a short course of chloramphenicol, steroid or lubricant eye drops. Read More

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http://dx.doi.org/10.1016/j.clae.2016.01.009DOI Listing
August 2016
6 Reads