Eye Contact Lens 2020 Mar;46 Suppl 2:S57-S63
Department of Ophthalmology (E.C.J.), Columbia University Medical Center, New York, NY; Bascom Palmer Eye Institute (A.M.E., T.K.E.), University of Miami Miller School of Medicine, Miami, FL; Department of Ophthalmology (A.M.E., R.H.E., Y.M.E.S.), Kasr Al-Ainy, Cairo University, Giza, Egypt; and Department of Ophthalmology (T.K.E.), Faculty of Medicine, Benha University, Benha, Egypt.
Objectives: (1) To explore the role and significance of Matrix Metalloproteinase 9 (MMP-9), a proteolytic enzyme, in various ocular surface diseases of inflammatory, infectious, and traumatic etiology (2), to further elucidate the molecular mechanisms responsible for its overexpression in ocular surface disease states, and (3) to discuss possible targets of therapeutic intervention.
Methods: A literature review was conducted of primary sources from 1995 onward using search results populated from the US National Library of Medicine search database.
Results: MMP-9 overexpression has been found in in vitro and in vivo models of dry eye disease (DED), corneal ulceration, microbial keratitis, corneal neovascularization, ultraviolet light-induced radiation, and a host of additional surface pathologies. Read More