38,202 results match your criteria Ultrasonography in Breast Cancer


Breast cancer survivors' risk of interval cancers and false positive results in organized mammography screening.

Cancer Med 2020 Jun 30. Epub 2020 Jun 30.

Department of Public Health Programmes, Regional Hospital Randers, Randers, Denmark.

Background: Breast cancer survivors are increasing followed for new breast cancers / recurrences by mammography screening only. We aimed at assessing how often breast cancer survivors get a false positive or false negative result at mammography screening.

Methods: All mammography screenings performed between 2007 and 2017 in the Danish national mammography screening programme were included. Read More

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http://dx.doi.org/10.1002/cam4.3182DOI Listing

Proteomics of Sentinel Lymph Nodes in Early Breast Cancer for Identification of Thymidylate Synthase as a Potential Biomarker to Flag Metastasis: A Preliminary Study.

Cancer Manag Res 2020 23;12:4841-4854. Epub 2020 Jun 23.

Department of Biophysics, All India Institute of Medical Sciences, New Delhi 110029, India.

Introduction: Breast cancer is the second most common cancer in women across the world. Some of the patients who present in the early stage of disease are affected by metastasis to the axillary group of lymph nodes. The first among this group that is affected is called as sentinel lymph node, and its diagnosis is crucial for the staging of cancer thereby dictating the type of surgical therapy. Read More

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http://dx.doi.org/10.2147/CMAR.S255684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320752PMC

Multifunctional Nanoparticles Encapsulating Astragalus Polysaccharide and Gold Nanorods in Combination with Focused Ultrasound for the Treatment of Breast Cancer.

Int J Nanomedicine 2020 12;15:4151-4169. Epub 2020 Jun 12.

Institute of Ultrasound Imaging, Chongqing Medical University, Chongqing 400010, People's Republic of China.

Purpose: Focused ultrasound (FUS) is a noninvasive method to produce thermal and mechanical destruction along with an immune-stimulatory effect against cancer. However, FUS ablation alone appears insufficient to generate consistent antitumor immunity. In this study, a multifunctional nanoparticle was designed to boost FUS-induced immune effects and achieve systemic, long-lasting antitumor immunity, along with imaging and thermal enhancement. Read More

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http://dx.doi.org/10.2147/IJN.S246447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305853PMC

Characteristics and Clinical Outcomes of Individuals at High Risk for Pancreatic Cancer: A Descriptive Analysis from a Comprehensive Cancer Center.

Gastrointest Disord (Basel) 2019 Mar 1;1(1):106-119. Epub 2018 Nov 1.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

Pancreatic cancer (PC), a leading cause of cancer-related deaths in the United States, is typically diagnosed at an advanced stage. To improve survival, there is an unmet need to detect pre-malignant lesions and early invasive disease. Prime populations to study for early detection efforts include cohorts of high risk individuals (HRI): those with increased risk to develop pre-malignant pancreatic cysts and PC because of a familial or hereditary predisposition to the disease and those in the general population of sporadic cases who are incidentally found to harbor a pre-malignant pancreatic cyst. Read More

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http://dx.doi.org/10.3390/gidisord1010008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324042PMC

Quantitative ultrasound radiomics in predicting response to neoadjuvant chemotherapy in patients with locally advanced breast cancer: Results from multi-institutional study.

Cancer Med 2020 Jun 29. Epub 2020 Jun 29.

Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Background: This study was conducted in order to develop a model for predicting response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC) using pretreatment quantitative ultrasound (QUS) radiomics.

Methods: This was a multicenter study involving four sites across North America, and appropriate approval was obtained from the individual ethics committees. Eighty-two patients with LABC were included for final analysis. Read More

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http://dx.doi.org/10.1002/cam4.3255DOI Listing

Myxofibrosarcoma that Developed Rapidly in the Breast of an Elderly Man and Recurred Early after Surgery: A Case Report.

Tokai J Exp Clin Med 2020 Jul 20;45(2):53-57. Epub 2020 Jul 20.

Department of Breast and Endocrine Surgery, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259-1193, Japan.

Background: Myxofibrosarcoma is a rare disease occurring subcutaneously in the limbs. We report a case of a rapidly growing myxofibrosarcoma in the breast of an elderly man that recurred early after surgery.

Case Presentation: A 73-year-old man presented with a breast mass. Read More

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Contrast-enhanced ultrasonography and blue dye methods in detection of sentinel lymph nodes following neoadjuvant chemotherapy in initially node positive breast cancer.

Arch Gynecol Obstet 2020 Jun 29. Epub 2020 Jun 29.

Department of Pathology, Fujian Medical University Cancer Hospital and Fujian Cancer Hospital, Fuzhou, 350014, Fujian, People's Republic of China.

Background: Recent studies show that contrast-enhanced ultrasonography (CEUS) using SonoVue has the potential to improve the performance of sentinel lymph node biopsy (SLNB) in patients with early breast cancer. However, the evidence of SLNB using CEUS in patients converting from cN1 to cN0 after neoadjuvant chemotherapy (NAC) is lacking. The aim of this prospective study is to evaluate the feasibility of CEUS using SonoVue for the identification of sentinel lymph node (SLN) and the value of the combination of CEUS and blue dye (BD) for SLNB in patients converting from cN1 to cN0 following NAC. Read More

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http://dx.doi.org/10.1007/s00404-020-05646-8DOI Listing

A deep learning methodology for improved breast cancer diagnosis using multiparametric MRI.

Sci Rep 2020 Jun 29;10(1):10536. Epub 2020 Jun 29.

Committee on Medical Physics, Department of Radiology, The University of Chicago, 5841 S Maryland Ave., Chicago, IL, MC202660637, USA.

Multiparametric magnetic resonance imaging (mpMRI) has been shown to improve radiologists' performance in the clinical diagnosis of breast cancer. This machine learning study develops a deep transfer learning computer-aided diagnosis (CADx) methodology to diagnose breast cancer using mpMRI. The retrospective study included clinical MR images of 927 unique lesions from 616 women. Read More

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http://dx.doi.org/10.1038/s41598-020-67441-4DOI Listing

Magnetic resonance activatable thermosensitive liposomes for controlled doxorubicin delivery.

Mater Sci Eng C Mater Biol Appl 2020 Oct 25;115:111116. Epub 2020 May 25.

Department of Pharmaceutics and Biopharmaceutics, University of Marburg, 35037 Marburg, Germany. Electronic address:

To limit the massive cytotoxicity of chemotherapeutic agents, it is desirable to establish an appropriate subtle blend of formulation design based on a dual-responsive strategy. In this study, a combined therapeutic platform based on magnetic thermosensitive liposomes (Lip) was developed. The incorporation of chelated-gadolinium imparted magnetic properties to thermosensitive liposomes (Lip). Read More

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http://dx.doi.org/10.1016/j.msec.2020.111116DOI Listing
October 2020

Biomimetic theranostic strategy for anti-metastasis therapy of breast cancer via the macrophage membrane camouflaged superparticles.

Mater Sci Eng C Mater Biol Appl 2020 Oct 14;115:111097. Epub 2020 May 14.

Department of Pharmaceutical Engineering and Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address:

The rational design of theranostic systems are critical for addressing challenging issues associated with cancers. Toward this objective, the multifunctional biomimetic superparticle, termed as DOX-QDs-Lip@M, which can specifically deliver drug to tumor and synergistically monitor their therapeutic effects, was fabricated. Initially, anticancer drug doxorubicin hydrochloride (DOX) and imaging agent quaternary quantum dots (QDs) were loaded into the hydrophilic core region and hydrophobic chamber of liposome by self-assembly method, respectively. Read More

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http://dx.doi.org/10.1016/j.msec.2020.111097DOI Listing
October 2020

Challenge for Diagnostic Assessment of Deep Learning Algorithm for Metastases Classification in Sentinel Lymph Nodes on Frozen Tissue Section Digital Slides in Women with Breast Cancer.

Cancer Res Treat 2020 Jun 30. Epub 2020 Jun 30.

Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea.

Purpose: Assessing the status of metastasis in sentinel lymph nodes (SLNs) by pathologists is an essential task for the accurate staging of breast cancer. However, histopathological evaluation of sentinel lymph nodes by a pathologist is not easy and is a tedious and time-consuming task. The purpose of this study is to review a challenge competition (HeLP 2018) to develop automated solutions for the classification of metastases in hematoxylin and eosin-stained frozen tissue sections of SLNs in breast cancer patients. Read More

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http://dx.doi.org/10.4143/crt.2020.337DOI Listing

Multiparametric Analysis of Longitudinal Quantitative MRI data to Identify Distinct Tumor Habitats in Preclinical Models of Breast Cancer.

Cancers (Basel) 2020 Jun 24;12(6). Epub 2020 Jun 24.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78712, USA.

This study identifies physiological tumor habitats from quantitative magnetic resonance imaging (MRI) data and evaluates their alterations in response to therapy. Two models of breast cancer (BT-474 and MDA-MB-231) were imaged longitudinally with diffusion-weighted MRI and dynamic contrast-enhanced MRI to quantify tumor cellularity and vascularity, respectively, during treatment with trastuzumab or albumin-bound paclitaxel. Tumors were stained for anti-CD31, anti-Ki-67, and H&E. Read More

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http://dx.doi.org/10.3390/cancers12061682DOI Listing

The feasibility of ultrasound-guided vacuum-assisted evacuation of large breast hematomas.

Radiol Oncol 2020 Jun 26. Epub 2020 Jun 26.

Kuopio University Hospital, Diagnostic Imaging Center, Department of Clinical Radiology, Kuopio, Finland.

Background Breast hematoma is an often underrated and disregarded post-procedural complication in the literature. Current treatment modalities are comprised of either surgical or expectant therapy, while percutaneous procedures play a smaller role in their treatment. We aimed to examine the efficacy of vacuum-assisted evacuation (VAE) in the treatment of clinically significant large breast hematomas as an alternative to surgery. Read More

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http://dx.doi.org/10.2478/raon-2020-0041DOI Listing

Clinical imaging for the prediction of neoadjuvant chemotherapy response in breast cancer.

Chin Clin Oncol 2020 Jun;9(2):31

Department of Breast and Endocrine Surgery, Kumamoto City Hospital, 4-1-60 Higashimachi, Higashi-ku, Kumamoto 862-8505, Japan.

Increased use of cancer screening, improved imaging, and diagnostic intervention techniques has led to the diagnosis of smaller cancers, including breast cancer. Most breast cancer patients receive systemic therapy, and some treatments are given before surgery, such as neoadjuvant therapy, even in an operable setting. Improved neoadjuvant chemotherapy has increased rates of pathological complete response; however, surgery is still required to determine complete tumor remission. Read More

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http://dx.doi.org/10.21037/cco-20-15DOI Listing

Improved characterization of sub-centimeter enhancing breast masses on MRI with radiomics and machine learning in BRCA mutation carriers.

Eur Radiol 2020 Jun 27. Epub 2020 Jun 27.

Department of Radiology, Breast Imaging Service, Memorial Sloan Kettering Cancer Center, 300 E 66th Street, New York, NY, 10065, USA.

Objectives: To investigate whether radiomics features extracted from MRI of BRCA-positive patients with sub-centimeter breast masses can be coupled with machine learning to differentiate benign from malignant lesions using model-free parameter maps.

Methods: In this retrospective study, BRCA-positive patients who had an MRI from November 2013 to February 2019 that led to a biopsy (BI-RADS 4) or imaging follow-up (BI-RADS 3) for sub-centimeter lesions were included. Two radiologists assessed all lesions independently and in consensus according to BI-RADS. Read More

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http://dx.doi.org/10.1007/s00330-020-06991-7DOI Listing

Dose reduction in mammography by using imaging plate technology: A retrospective analysis.

Eur J Radiol 2020 Jun 19;129:109140. Epub 2020 Jun 19.

Universitätsklinikum Augsburg, Klinik für Diagnostische Radiologie und Neuroradiologie, Stenglinstr. 2, 86156, Augsburg, Deutschland.

Purpose: Conventional mammography is a decisive tool in detecting breast cancer. Continuous efforts are undertaken in order to further improve the image quality as well as to reduce the applied doses. The purpose of our study was to compare diagnostic image quality of dose reduced computed mammography with a new needle-based detector system to full dose powder imaging plates. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109140DOI Listing

Virtual Interpolation Images of Tumor Development and Growth on Breast Ultrasound Image Synthesis With Deep Convolutional Generative Adversarial Networks.

J Ultrasound Med 2020 Jun 27. Epub 2020 Jun 27.

Department of Diagnostic Radiology, Tokyo Medical and Dental University, Tokyo, Japan.

Objectives: We sought to generate realistic synthetic breast ultrasound images and express virtual interpolation images of tumors using a deep convolutional generative adversarial network (DCGAN).

Methods: After retrospective selection of breast ultrasound images of 528 benign masses, 529 malignant masses, and 583 normal breasts, 20 synthesized images of each were generated by the DCGAN. Fifteen virtual interpolation images of tumors were generated by changing the value of the input vector. Read More

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http://dx.doi.org/10.1002/jum.15376DOI Listing

A rapid volume of interest-based approach of radiomics analysis of breast MRI for tumor decoding and phenotyping of breast cancer.

PLoS One 2020 26;15(6):e0234871. Epub 2020 Jun 26.

Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.

Background: Recently, radiomics has emerged as a non-invasive, imaging-based tissue characterization method in multiple cancer types. One limitation for robust and reproducible analysis lies in the inter-reader variability of the tumor annotations, which can potentially cause differences in the extracted feature sets and results. In this study, the diagnostic potential of a rapid and clinically feasible VOI (Volume of Interest)-based approach to radiomics is investigated to assess MR-derived parameters for predicting molecular subtype, hormonal receptor status, Ki67- and HER2-Expression, metastasis of lymph nodes and lymph vessel involvement as well as grading in patients with breast cancer. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234871PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319601PMC

Peritumor to tumor apparent diffusion coefficient ratio is associated with biologically more aggressive breast cancer features and correlates with the prognostication tools.

PLoS One 2020 25;15(6):e0235278. Epub 2020 Jun 25.

Institute of Clinical Medicine, School of Medicine, Clinical Radiology, University of Eastern Finland, Kuopio, Finland.

Purpose: The apparent diffusion coefficient (ADC) is increasingly used to characterize breast cancer. The peritumor/tumor ADC ratio is suggested to be a reliable and generally applicable index. However, its overall prognostication value remains unclear. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235278PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316248PMC

Four cases of Trousseau syndrome associated with breast cancer that exhibited central nervous system manifestations.

Int Cancer Conf J 2020 Jul 4;9(3):146-150. Epub 2020 Apr 4.

Department of Breast-Thyroid-Endocrine Surgery, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki Japan.

Cancer-associated thrombosis is known as Trousseau syndrome (TS). Here, we report 4 cases of TS associated with advanced breast cancer that caused central nervous system (CNS) vascular events. All 4 patients experienced sudden onset of CNS symptoms. Read More

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http://dx.doi.org/10.1007/s13691-020-00411-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297874PMC

A Cross-Sectional Observational Study to Compare the Role of Ultrasound with Mammography in Women Identified at High Risk for Breast Cancer in a Population in China.

Med Sci Monit 2020 Jun 24;26:e919777. Epub 2020 Jun 24.

Medical Ultrasound Center, Northwest Women's and Children's Hospital, Xi'an, Shaanxi, China (mainland).

BACKGROUND Currently, there is no national breast cancer screening program in China. In countries that have screening programs, screening mammography is used. This study aimed to compare the imaging parameters and diagnostic findings between ultrasound and mammography in women at high risk who had a histologically confirmed diagnosis of breast cancer in a population in China. Read More

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http://dx.doi.org/10.12659/MSM.919777DOI Listing

Thyroid cancer neck lymph nodes metastasis: Meta-analysis of US and CT diagnosis.

Eur J Radiol 2020 Jun 13;129:109103. Epub 2020 Jun 13.

Center of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, People's Republic of China. Electronic address:

Purpose: Ultrasound (US) is the first imaging technique in the assessment of cervical lymph nodes metastasis (LNM) of papillary thyroid cancer (PTC) patients preoperatively. Computed tomography (CT) exerts an influence on surgical strategy especially for patients with lateral cervical LNM. This meta-analysis aimed at assessing the diagnostic values of US and CT in detecting the cervical LNM in thyroid cancer patients. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109103DOI Listing

Relaxation-compensated CEST (chemical exchange saturation transfer) imaging in breast cancer diagnostics at 7T.

Eur J Radiol 2020 May 24;129:109068. Epub 2020 May 24.

Division of Radiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. Electronic address:

Purpose: To investigate whether fat-corrected and relaxation-compensated amide proton transfer (APT) and guanidyl CEST-MRI enables the detection of signal intensity differences between breast tumors and normal-appearing fibroglandular tissue in patients with newly-diagnosed breast cancer.

Method: Ten patients with newly-diagnosed breast cancer and seven healthy volunteers were included in this prospective IRB-approved study. CEST-MRI was performed on a 7 T-whole-body scanner followed by a multi-Lorentzian fit analysis. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.109068DOI Listing

The diagnostic performance of CESM and CE-MRI in evaluating the pathological response to neoadjuvant therapy in breast cancer: A systematic review and meta-analysis.

Br J Radiol 2020 Jun 23:20200301. Epub 2020 Jun 23.

Department of Radiology, The Yongchuan Affiliated Hospital, Medical University, Yongchuan District, Chongqing, PR China.

Objectives: Neoadjuvant chemotherapy (NAC) is an important method for breast cancer treatment. By monitoring its pathological response, the selection of clinical treatment strategies can be guided. In this study, the meta-analysis was used to compare the accuracy of contrast-enhanced magnetic resonance imaging (CE-MRI) and Contrast-enhanced Spectral Mammography (CESM) in detecting the pathological response of NAC. Read More

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http://dx.doi.org/10.1259/bjr.20200301DOI Listing

Determining the thermal characteristics of breast cancer based on high-resolution infrared imaging, 3D breast scans, and magnetic resonance imaging.

Sci Rep 2020 Jun 22;10(1):10105. Epub 2020 Jun 22.

Department of Mechanical Engineering, The University of Texas at Dallas, 800 W Campbell Rd ECW-31, Richardson, TX, 75080, USA.

For over the three decades, various researchers have aimed to construct a thermal (or bioheat) model of breast cancer, but these models have mostly lacked clinical data. The present study developed a computational thermal model of breast cancer based on high-resolution infrared (IR) images, real three-dimensional (3D) breast surface geometries, and internal tumor definition of a female subject histologically diagnosed with breast cancer. A state-of-the-art IR camera recorded IR images of the subject's breasts, a 3D scanner recorded surface geometries, and standard diagnostic imaging procedures provided tumor sizes and spatial locations within the breast. Read More

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http://dx.doi.org/10.1038/s41598-020-66926-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7308290PMC

CHEK2 Mutation in Patient with Multiple Endocrine Glands Tumors. Case Report.

Int J Environ Res Public Health 2020 Jun 18;17(12). Epub 2020 Jun 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Read More

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http://dx.doi.org/10.3390/ijerph17124397DOI Listing

Full-field digital mammography: the '30% rule' and influences on visualisation of the pectoralis major muscle on the craniocaudal view of the breast.

J Med Radiat Sci 2020 Jun 22. Epub 2020 Jun 22.

Faculty of Science, School of Dentistry & Health Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.

Introduction: To investigate compliance to the '30% rule' and key factors which may influence visualisation of the pectoralis major muscle (PMM) on the craniocaudal (CC) view of the breast.

Methods: A retrospective review of 2688 paired full-field digital mammography (FFDM) CC view mammograms of women attending BreastScreen NSW between August and October 2015 was undertaken. PMM visualisation and measurements of PMM width and length, compressed breast thickness, the posterior nipple line (PNL) and age were recorded. Read More

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http://dx.doi.org/10.1002/jmrs.404DOI Listing

PET/CT and MRI for Identifying Axillary Lymph Node Metastases in Breast Cancer Patients: Systematic Review and Meta-Analysis.

J Magn Reson Imaging 2020 Jun 21. Epub 2020 Jun 21.

Department of Breast Surgery, Sichuan Cancer Hospital and Research Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology, Chengdu, China.

Background: Axillary lymph node metastases (ALNM) is one of the most important prognostic factors in breast cancer. Positron emission tomography / computed tomography (PET/CT) and magnetic resonance imaging (MRI) are increasingly used to assess ALNM noninvasively. There has been no study investigating PET/CT and MRI in direct comparative studies. Read More

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http://dx.doi.org/10.1002/jmri.27246DOI Listing

Valvular Damage.

J Cardiovasc Echogr 2020 Apr 10;30(Suppl 1):S26-S32. Epub 2020 Apr 10.

Department of Heart, University Hospital of Salerno, Salerno, Italy.

Valvular heart diseases (VHD) may be observed in patients with cancer for several reasons, including preexisting valve lesions, radiotherapy, infective endocarditis, and secondary to the left ventricle dysfunction. The incidence of VHD is especially in younger survivors treated with thoracic radiation therapy for certain malignancies, such as Hodgkin's lymphoma and breast cancer. The mechanism of radiation-induced damage to heart valves is not clear and includes diffuse fibrocalcific thickening of the valve. Read More

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http://dx.doi.org/10.4103/jcecho.jcecho_5_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7293871PMC

Mammographic density changes during neoadjuvant breast cancer treatment: NeoDense, a prospective study in Sweden.

Breast 2020 Jun 4;53:33-41. Epub 2020 Jun 4.

Division of Oncology and Pathology, Department of Clinical Sciences, Lund University, Skåne University Hospital, Lund, Sweden; Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. Electronic address:

Objectives: To assess if mammographic density (MD) changes during neoadjuvant breast cancer treatment and is predictive of a pathological complete response (pCR).

Methods: We prospectively included 200 breast cancer patients assigned to neoadjuvant chemotherapy (NACT) in the NeoDense study (2014-2019). Raw data mammograms were used to assess MD with a fully automated volumetric method and radiologists categorized MD using the Breast Imaging-Reporting and Data System (BI-RADS), 5th Edition. Read More

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http://dx.doi.org/10.1016/j.breast.2020.05.013DOI Listing

Correlation between imaging features and molecular subtypes of breast cancer in young women (≤30 years old).

Jpn J Radiol 2020 Jun 19. Epub 2020 Jun 19.

Department of Breast Radiology, Affiliated Hospital of Qingdao University, Qingdao University, No. 16, Jiangsu Road, Qingdao, 266100, Shandong Province, China.

Objectives: To analyze the features of digital mammography (DM) plus digital breast tomosynthesis (DBT), ultrasonography (US) and magnetic resonance imaging (MRI) of breast cancer in young women (≤30 years old) and the correlation with molecular subtypes.

Materials And Methods: We performed a retrospective study of imaging features of consecutive young women aged ≤30 years who were treated and surgically confirmed with breast cancer between January 2013 and December 2019 in our institution. All patients were Chinese women. Read More

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http://dx.doi.org/10.1007/s11604-020-01001-8DOI Listing

Invasive solid papillary carcinoma with neuroendocrine differentiation of the breast: a case report and literature review.

Surg Case Rep 2020 Jun 19;6(1):143. Epub 2020 Jun 19.

Department of Breast Surgery, Kyoto University Hospital, 54 Kawaharacho, Syogoin, Sakyo-ku, Kyoto, 606-8507, Japan.

Background: Solid papillary carcinoma (SPC) of the breast is a rare breast cancer that accounts for less than 1% of all breast cancers. The optimal clinical management of SPC remains controversial. Here, we report a case of invasive SPC with neuroendocrine differentiation in addition to review of the current literature. Read More

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http://dx.doi.org/10.1186/s40792-020-00905-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305294PMC

Imaging and biodistribution of radiolabeled SP90 peptide in BT-483 tumor bearing mice.

Appl Radiat Isot 2020 Jul 2;161:109162. Epub 2020 Apr 2.

Isotope Application Division, Institute of Nuclear Energy Research, Taoyuan, Taiwan. Electronic address:

The objective of this study was to evaluate radiolabeled DOTA-SP90 as a radiotracer for breast cancer. The in vitro competition assay showed that radiolabeled DOTA-SP90 had significant binding affinity to BT-483 cancer cells. Biodistribution, nanoSPECT/CT and nanoPET/CT imaging results indicated that radiolabeled DOTA-SP90 can accumulate in tumors. Read More

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http://dx.doi.org/10.1016/j.apradiso.2020.109162DOI Listing

Detection of the 'systemic sentinel lymph node' in colorectal cancer using fluorescence imaging after indocyanine green intravenous injection: A feasibility study.

JMIR Res Protoc 2020 Jun 15. Epub 2020 Jun 15.

Institut Jules Bordet, Belgian Comprehensive Cancer Center, Université Libre de Bruxelles (ULB), BE 0257.981.101., Rue H. Bordet, 1, Brussels, BE.

Background: Nodal staging is a major concern in colorectal cancer (CRC) as it is an important prognostic factor. Several techniques have been developed to increase the accuracy of nodal staging that could potentially improve patient treatment and prognosis. Sentinel lymph node (SLN) detection has been shown to accurately reflect nodal status in various tumors and has become the standard procedure in nodal staging of breast cancer and melanoma. Read More

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http://dx.doi.org/10.2196/17976DOI Listing

Prospective evaluation of contrast-enhanced ultrasound of breast BI-RADS 3-5 lesions.

BMC Med Imaging 2020 Jun 17;20(1):66. Epub 2020 Jun 17.

The Clinic of Radiology and Nuclear Medicine, The University Hospital Brno, Brno, Czech Republic.

Background: To determine the benefit of contrast-enhanced ultrasound (CEUS) in the assessment of breast lesions.

Methods: A standardized contrast-enhanced ultrasound was performed in 230 breast lesions classified as BI-RADS category 3 to 5. All lesions were subjected to qualitative and quantitative analysis. Read More

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http://dx.doi.org/10.1186/s12880-020-00467-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302394PMC

Automated breast ultrasound compared to hand-held ultrasound in surveillance after breast-conserving surgery.

Tumori 2020 Jun 18:300891620930278. Epub 2020 Jun 18.

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milano, Italy.

Purpose: To investigate the agreement between automated breast ultrasound (ABUS) and hand-held ultrasound (HHUS) in surveillance of women with a history of breast cancer in terms of recurrences or new ipsilateral or contralateral breast cancer.

Methods: The institutional review board approved this retrospective study and informed consent was waived. From April to June 2016, women with dense breasts undergoing annual surveillance with mammography and HHUS after breast-conserving surgery were offered supplemental ABUS (Invenia). Read More

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http://dx.doi.org/10.1177/0300891620930278DOI Listing

Molecular Breast Imaging in Clinical Practice.

AJR Am J Roentgenol 2020 Jun 17:1-8. Epub 2020 Jun 17.

Department of Radiology, Mayo Clinic, Rochester, MN.

The purpose of this article is to review clinical uses and image interpretation of molecular breast imaging (MBI) and clarify radiation risks. MBI detects additional cancers compared with conventional imaging in women with dense breasts and those with elevated risk of breast cancer. Its role as an imaging biomarker of cancer risk and in assessing neoadjuvant chemotherapy response is growing. Read More

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http://dx.doi.org/10.2214/AJR.19.22622DOI Listing

Value of tomography in detecting breast masses and discriminating malign and benign lesions.

Turk J Surg 2019 Dec 16;35(4):265-272. Epub 2019 Dec 16.

Karadeniz Teknik Üniversitesi Tıp Fakültesi, Radyoloji Anabilim Dalı, Trabzon, Türkiye.

Objectives: The main purpose of the present study was to determine the effectivity of computerized tomography (CT) in detecting breast masses and discriminating masses as malignant or benign.

Material And Methods: After having received the institutional local ethics committee approval, an experienced radiologist who did not participate in the study created a patient pool by searching our health center's Pathology department database between 2010 and 2018. The group created consisted of dense and non-dense breast types equally and included approximately similar percentages of benign and malignant breast mass sizes. Read More

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http://dx.doi.org/10.5578/turkjsurg.4258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282456PMC
December 2019

Quantitative Comparison of Prone and Supine PERCIST Measurements in Breast Cancer.

Tomography 2020 Jun;6(2):170-176

Oden Institute for Computational Engineering and Sciences; Livestrong Cancer Institutes; Department of Biomedical Engineering; Department of Diagnostic Medicine; and Department of Oncology, The University of Texas, Austin, TX.

Positron emission tomography (PET) is typically performed in the supine position. However, breast magnetic resonance imaging (MRI) is performed in prone, as this improves visibility of deep breast tissues. With the emergence of hybrid scanners that integrate molecular information from PET and functional information from MRI, it is of great interest to determine if the prognostic utility of prone PET is equivalent to supine. Read More

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http://dx.doi.org/10.18383/j.tom.2020.00002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289244PMC

Discrimination of Malignant and Benign Breast Lesions Using Quantitative Multiparametric MRI: A Preliminary Study.

Tomography 2020 Jun;6(2):148-159

Advanced Imaging Research Center, Oregon Health & Science University, Portland, OR; and.

We aimed to compare diagnostic performance in discriminating malignant and benign breast lesions between two intravoxel incoherent motion (IVIM) analysis methods for diffusion-weighted magnetic resonance imaging (DW-MRI) data and between DW- and dynamic contrast-enhanced (DCE)-MRI, and to determine if combining DW- and DCE-MRI further improves diagnostic accuracy. DW-MRI with 12 b-values and DCE-MRI were performed on 26 patients with 28 suspicious breast lesions before biopsies. The traditional biexponential fitting and a 3-b-value method were used for independent IVIM analysis of the DW-MRI data. Read More

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http://dx.doi.org/10.18383/j.tom.2019.00028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7289240PMC

Diagnostic Value of Elastography, Strain Ratio, and Elasticity to B-Mode Ratio and Color Doppler Ultrasonography in Breast Lesions.

Int J Gen Med 2020 25;13:215-224. Epub 2020 May 25.

Social Determinant of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Purpose: The aim of this study was to investigate the sensitivity, specificity, and diagnostic accuracy of sonoelastography (SE), strain ratio (SR), elasticity to B-mode (E/B) ratio, and color Doppler ultrasonography (US) in suspected breast lesions.

Materials And Methods: This prospective study was conducted on women referred to Alzahra university hospital of Tabriz for annual screening of breast cancer between May 2017 and December 2018. B-mode US, SE, and color Doppler imaging were conducted in females with suspected mammography reports. Read More

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http://dx.doi.org/10.2147/IJGM.S247980DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259450PMC

Can Magnetic Resonance Imaging Replace Mammography and Ultrasonography for the Detection of Breast Lesions?

Cureus 2020 May 13;12(5):e8087. Epub 2020 May 13.

General Surgery, İzmir Katip Celebi University, Atatürk Training and Research Hospital, İzmir, TUR.

Objective We aimed to evaluate the role of magnetic resonance imaging (MRI) in the visualization of breast lesions and to estimate whether MRI can be a reliable alternative to mammography (MG) and ultrasonography (USG) for this purpose. Materials and methods In this retrospective, single-center study, an analysis of medical files of 260 patients with breast masses as breast imaging reports and data system (BI-RADS) 4 and 5 at MRI was performed. The features of the breast lump, such as the side, location, multi foci or multicentricity, histopathological diagnosis, contrast-enhancement characteristics, radiological, and pathological axillary involvement, were noted. Read More

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http://dx.doi.org/10.7759/cureus.8087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7292694PMC

Relationship between perimetric increase and fluoroscopic pattern type in secondary upper limb lymphedema observed by Indocyanine green lymphography.

Medicine (Baltimore) 2020 Jun;99(24):e20432

Department of Physiotherapy, University of Seville, Spain.

To ascertain the relationship between the perimetric differences obtained between the limbs and the type of fluoroscopic pattern observed by Indocyanine green (ICG) lymphography in patients with upper limb lymphedema.A correlational descriptive study was carried out in 19 patients with upper limb lymphedema secondary to breast cancer. The perimetric increase was recorded in 11 anatomical regions after ICG injection, fluoroscopic patterns were identified using an infrared camera. Read More

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http://dx.doi.org/10.1097/MD.0000000000020432DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302654PMC

Diagnostic accuracy of contrast-enhanced spectral mammography for breast lesions: A systematic review and meta-analysis.

Breast 2020 Jun 10;53:8-17. Epub 2020 Jun 10.

Department of Medicine and Surgery, University of Insubria, Como, Italy. Electronic address:

Breast cancer diagnosis and staging is based on mammography, ultrasound, and magnetic resonance imaging (MRI). Contrast enhanced spectral mammography (CESM) has gained momentum as an innovative and clinically useful method for breast assessment. CESM is based on abnormal enhancement of neoplastic tissue compared to surrounding breast tissue. Read More

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http://dx.doi.org/10.1016/j.breast.2020.06.005DOI Listing

Would Removal of All Ultrasound Abnormal Metastatic Lymph Nodes Without Sentinel Lymph Node Biopsy Be Accurate in Patients with Breast Cancer with Neoadjuvant Chemotherapy?

Oncologist 2020 Jun 14. Epub 2020 Jun 14.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore.

Lessons Learned: Removal of sonographically abnormal (up to 3) metastatic clipped nodes, without sentinel lymph node biopsy, could accurately predict axillary status in breast cancer patients receiving neoadjuvant chemotherapy. ypT and the first clipped node status were statistically significant factors for nodal pathologic complete response. This novel approach requires validation in larger studies. Read More

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http://dx.doi.org/10.1634/theoncologist.2020-0494DOI Listing

Radiation-induced Osteomyelitis/Osteonecrosis of the Rib: SPECT/CT Imaging for Successful Surgical Management.

Plast Reconstr Surg Glob Open 2019 Dec 30;7(12):e2536. Epub 2019 Dec 30.

Department of Plastic and Reconstructive Surgery, Keio University School of Medicine, Tokyo, Japan.

Chronic radiation-induced osteomyelitis/necrosis of the rib was rarely encountered in breast cancer patients even before the era of breast-conserving therapy. Few studies have focused on how to evaluate the extent of rib osteomyelitis for surgical management. A 78-year-old woman who had received radiation therapy after a radical mastectomy due to breast cancer 30 years ago manifested a rib pain and chest skin ulcers. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7288890PMC
December 2019

Background parenchymal enhancement and its effect on lesion detectability in ultrafast dynamic contrast-enhanced MRI.

Eur J Radiol 2020 Apr 18;129:108984. Epub 2020 Apr 18.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto, 606-8507, Japan.

Purpose: Background parenchymal enhancement (BPE) often affects interpretation of dynamic contrast-enhanced (DCE) MRI. There is limited evidence that reduced BPE is a feature of ultrafast DCE (UF-DCE) MRI. We aimed to evaluate the effect of BPE levels on lesion detectability on UF-DCE MRI in comparison with conventional DCE MRI. Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108984DOI Listing

Biochemistry may be misleading in metachronous MEN2A-associated phaeochromocytoma following unilateral total adrenalectomy.

BMJ Case Rep 2020 Jun 11;13(6). Epub 2020 Jun 11.

Endocrinology, Royal North Shore Hospital School, Saint Leonards, New South Wales, Australia.

A 63-year-old woman with multiple endocrine neoplasia type 2A (MEN2A) presented with recurrent spells of headaches, sweats and palpitations decades after right adrenalectomy for phaeochromocytoma, and total thyroidectomy for medullary thyroid cancer. She was hypertensive and in sinus rhythm. DOTA-TATE positron-emission tomography (PET) demonstrated a 12mm enhancing left adrenal incidentaloma. Read More

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http://dx.doi.org/10.1136/bcr-2019-234132DOI Listing

Exploring Association of Breast Pain, Pregnancy, and Body Mass Index with Breast Tissue Elasticity in Healthy Women: Glandular and Fat Differences.

Diagnostics (Basel) 2020 Jun 10;10(6). Epub 2020 Jun 10.

Department of Diagnostic and Interventional Radiology, University Hospital Dubrava, Avenue Gojka Suska 6, 10000 Zagreb, Croatia.

Breast sonoelastography is a relatively novel ultrasound (US) method that enables estimation of tissue stiffness to estimate the elasticity of normal breast tissue and seek to correlate it with well-known breast cancer risk factors. Two hundred women of different age were included in the study and completed a questionnaire about personal, familiar, and reproductive history. Glandular and fatty tissue elasticity in all breast quadrants was measured by shear wave elastography (SWE). Read More

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http://dx.doi.org/10.3390/diagnostics10060393DOI Listing

A review on methods for diagnosis of breast cancer cells and tissues.

Cell Prolif 2020 Jun 12:e12822. Epub 2020 Jun 12.

Hunan Key Laboratory of Biomedical Nanomaterials and Devices, Hunan University of Technology, Zhuzhou, China.

Breast cancer has seriously been threatening physical and mental health of women in the world, and its morbidity and mortality also show clearly upward trend in China over time. Through inquiry, we find that survival rate of patients with early-stage breast cancer is significantly higher than those with middle- and late-stage breast cancer, hence, it is essential to conduct research to quickly diagnose breast cancer. Until now, many methods for diagnosing breast cancer have been developed, mainly based on imaging and molecular biotechnology examination. Read More

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http://dx.doi.org/10.1111/cpr.12822DOI Listing