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Medicine (Baltimore) 2019 Apr;98(16):e15175

Department of Computed Tomography, Affiliated Tumor Hospital of Xinjiang Medical University, Urumqi, China.

Background: Previous clinical studies have reported that full field digital mammography (FFDM) can be used for diagnosis on breast cancer (BC) with promising outcome results. However, no study systematically investigates its diagnostic impact on female patients with BC. Thus, this systematic review will assess the accurate of FFDM diagnosis on BC. Read More

J Cell Physiol 2019 Apr 21. Epub 2019 Apr 21.

Department of Chemical Engineering, University of Florida, Gainesville, Florida.

Breast cancer nuclei have highly irregular shapes, which are diagnostic and prognostic markers of breast cancer progression. The mechanisms by which irregular cancer nuclear shapes develop are not well understood. Here we report the existence of vertical, apical cell protrusions in cultured MDA-MB-231 breast cancer cells. Read More

Eur J Radiol 2019 May 28;114:51-56. Epub 2019 Feb 28.

Department of Biomedical Imaging and Image-Guided Therapy, Division of Molecular and Gender Imaging, Medical University of Vienna, Waehringer-Guertel 18-20, Vienna, Austria. Electronic address:

Objective: We performed a prospective monocentric study to inter-individually compare the diagnostic accuracy of breast MRI at 1.5 T and 3 T.

Methods: During a consecutive period of 12 months all 982 patients receiving breast MRI according to standard indications (problem solving, preoperative staging) were randomized to one 3 T or 1. Read More

Eur J Radiol 2019 May 21;114:167-174. Epub 2019 Mar 21.

Department of Diagnostic Radiology, Unit 1350, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX, 77030, USA. Electronic address:

Objective: Different molecular subtypes of triple-negative breast cancer (TNBC) have previously been identified through analysis of gene expression profiles. The luminal androgen receptor (LAR) subtype has been shown to have a lower rate of pathologic complete response to neoadjuvant chemotherapy than other TNBC subtypes. The purpose of this study was to determine if the imaging features of TNBCs differ by AR (androgen receptor) status, which is a surrogate immunohistochemical (IHC) marker for the chemoresistant LAR subtype of TNBC. Read More

JAMA Netw Open 2019 Apr 5;2(4):e192561. Epub 2019 Apr 5.

Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio.

Importance: There has been significant recent interest in understanding the utility of quantitative imaging to delineate breast cancer intrinsic biological factors and therapeutic response. No clinically accepted biomarkers are as yet available for estimation of response to human epidermal growth factor receptor 2 (currently known as ERBB2, but referred to as HER2 in this study)-targeted therapy in breast cancer.

Objective: To determine whether imaging signatures on clinical breast magnetic resonance imaging (MRI) could noninvasively characterize HER2-positive tumor biological factors and estimate response to HER2-targeted neoadjuvant therapy. Read More

Neuroradiology 2019 Apr 18. Epub 2019 Apr 18.

Diagnostic and Interventional Neuroradiology, Eberhard Karls University Tuebingen, Hoppe-Seyler-Str. 3, 72076, Tuebingen, Germany.

Purpose: To assess the prevalence of false-positive meningeal contrast enhancement in patients with solid tumors who were undergoing chemotherapy.

Methods: A total of 2572 magnetic resonance imaging (MRI) examinations of the brain were retrospectively evaluated by two readers for the presence of pathological meningeal contrast enhancement conspicuous for neoplastic meningitis. These patients either had malignant melanoma, breast or lung cancer, or lymphoma. Read More

Eur J Breast Health 2019 Apr 1;15(2):119-124. Epub 2019 Apr 1.

Department of Radiology, Hacettepe University School of Medicine, Ankara, Turkey.

Objective: Magnetic resonance imaging (MRI) and ultrasonography (US) are commonly used in the pre-surgery determination of tumor size and the follow-up of breast cancer patients treated with neoadjuvant chemotherapy (NAC). The aim of this study was to compare the efficiency of preoperative MRI and US in tumor size evaluation of patients with breast cancer after NAC to guide clinicians on the appropriate treatment plan.

Materials And Methods: The study included a total of 75 patients who had undergone radiological follow-up, surgical treatment and pathological examination in our hospital between 2013 and 2016. Read More

J Midlife Health 2019 Jan-Mar;10(1):29-32

Department of Obstetrics and Gynecology, NKP Salve Institute of Medical Sciences and Research Centre, Nagpur, Maharashtra, India.

Background: Prophylactic salpingo-oophorectomy refers to the removal of clinically normal ovaries at the time of hysterectomy for benign lesions, to reduce the risk of ovarian and breast cancer in future. This risk reduction holds true for high-risk women, i.e. Read More

Ultrasonography 2018 Dec 23. Epub 2018 Dec 23.

Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.

Purpose: The purpose of this study was to assess the reliability of automated breast ultrasound (ABUS) examinations of suspicious breast masses in comparison to handheld breast ultrasound (HHUS) with regard to Breast Imaging Reporting and Data System (BI-RADS) category assessment, and to investigate the factors affecting discrepancies in categorization.

Methods: A total of 135 masses that were assessed as BI-RADS categories 4 and 5 on ABUS that underwent ultrasound (US)-guided core needle biopsy from May 2017 to December 2017 were included in this study. The BI-RADS categories were re-assessed using HHUS. Read More

Med Glas (Zenica) 2019 Aug 1;16(2). Epub 2019 Aug 1.

Department of Thoracic Surgery, School of Medicine, Canakkale Onsekiz Mart University, Turkey.

Aim To evaluate the efficacy, safety and feasibility of mediastinoscopy in 107 cases with mediastinal lesions that could not be diagnosed histopathologically with other methods. Methods A total of 107 cases (73 males, 34 females; mean age 57.4, range 30-88 years) with mediastinal lymphadenopathy, who underwent mediastinoscopy between 12 September 2012 and 29 November 2018 were examined retrospectively. Read More

Korean J Radiol 2019 May;20(5):759-772

Department of Radiology, Korea University Ansan Hospital, Korea University College of Medicine, Ansan, Korea.

Objective: To investigate the value of ultrasound (US) microflow assessment in distinguishing malignant from benign solid breast masses as well as the association between US parameters and histologic microvessel density (MVD).

Materials And Methods: Ninety-eight breast masses (57 benign and 41 malignant) were examined using Superb Microvascular Imaging (SMI) and contrast-enhanced US (CEUS) before biopsy. Two radiologists evaluated the quantitative and qualitative vascular parameters on SMI (vascular index, morphology, distribution, and penetration) and CEUS (time-intensity curve analysis and enhancement characteristics). Read More

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Ultrasound, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education /Beijing), Peking University Cancer Hospital & Institute, Beijing, 100142, China.

Objectives: To determine whether radiofrequency ablation (RFA) is more effective when combined with intratumoural injection (IT) than with intravenous injection (IV) of micelles.

Materials And Methods: Balb/c mice bearing 4T1 breast cancer were used. The tumour drug accumulation and biodistribution in major organs were evaluated at different time points after IT, IV, IT+RFA and IV+RFA. Read More

Eur Radiol 2019 Apr 16. Epub 2019 Apr 16.

Department of Radiology and Nuclear Medicine, Radboud University Medical Center, PO Box 9101, 6500 HB, Nijmegen, The Netherlands.

Purpose: To study the feasibility of automatically identifying normal digital mammography (DM) exams with artificial intelligence (AI) to reduce the breast cancer screening reading workload.

Methods And Materials: A total of 2652 DM exams (653 cancer) and interpretations by 101 radiologists were gathered from nine previously performed multi-reader multi-case receiver operating characteristic (MRMC ROC) studies. An AI system was used to obtain a score between 1 and 10 for each exam, representing the likelihood of cancer present. Read More

Am Fam Physician 2019 Apr;99(8):505-514

Thomas Jefferson University, Philadelphia, PA, USA.

Palpable breast masses, mastalgia, and nipple discharge are commonly encountered symptoms in outpatient practice, causing significant patient anxiety and precipitating medical consultation. The initial workup includes a detailed clinical history and physical examination. Women presenting with a breast mass will require imaging and further assessment to exclude cancer. Read More

Breast Cancer Res Treat 2019 Apr 13. Epub 2019 Apr 13.

Center for Cancer and Aging, City of Hope National Medical Center, Duarte, CA, USA.

Purpose: Older cancer patients are at increased risk of cancer-related cognitive impairment. The purpose of this study was to assess the alterations in intrinsic brain activity associated with adjuvant chemotherapy in older women with breast cancer.

Methods: Chemotherapy treatment (CT) group included sixteen women aged ≥ 60 years (range 60-82 years) with stage I-III breast cancers, who underwent both resting-state functional magnetic resonance imaging (rs-fMRI) and neuropsychological testing with NIH Toolbox for Cognition before adjuvant chemotherapy, at time point 1 (TP1), and again within 1 month after completing chemotherapy, at time point 2 (TP2). Read More

Exp Ther Med 2019 May 6;17(5):3655-3663. Epub 2019 Mar 6.

Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.

The purpose of the present study was to investigate whether contrast-enhanced ultrasonography (CEUS) in combination with ultrasound elastography (UE) is able to accurately predict the efficacy of neoadjuvant chemotherapy (NAC) in breast cancer patients. A total of 65 breast cancer patients who received NAC at the First Affiliated Hospital of Zhejiang University (Hangzhou, China) between February 2016 and August 2017 and were recruited for the present study. Prior to and after NAC, examination by CEUS, UE or their combination was performed. Read More

Nat Commun 2019 Apr 15;10(1):1741. Epub 2019 Apr 15.

Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.

Genome-wide association studies (GWAS) have identified more than 170 breast cancer susceptibility loci. Here we hypothesize that some risk-associated variants might act in non-breast tissues, specifically adipose tissue and immune cells from blood and spleen. Using expression quantitative trait loci (eQTL) reported in these tissues, we identify 26 previously unreported, likely target genes of overall breast cancer risk variants, and 17 for estrogen receptor (ER)-negative breast cancer, several with a known immune function. Read More

Genet Test Mol Biomarkers 2019 Apr;23(4):264-269

1 Clinical Laboratory, Longgang Central Hospital of Shenzhen, Shenzhen, China.

Background: Qualitative and quantitative detection of circulating tumor DNA (ctDNA) is a liquid biopsy technology used for early cancer diagnosis. However, the plasma ctDNA content is extremely low, so it is difficult to detect somatic mutations of tumors using conventional sequencing methods. Target region sequencing (TRS) technology, through enrichment of the target genomic region followed by next generation sequencing, overcomes this challenge and has been widely used in ctDNA sequencing. Read More

Medicine (Baltimore) 2019 Apr;98(15):e15125

Department of Special Diagnosis.

To evaluate the diagnostic performance of percentage of hard component (PHC) versus strain ratio (SR) in focal breast lesion diagnosis.Ultrasonography and elastography images of 245 malignant and 255 benign breast lesions were obtained and analyzed according to the Breast Imaging-Reporting and Data System of the American College of Radiology. PHC and SR were measured for each lesion and receiver operating characteristic (ROC) curve analysis was performed to evaluate and compare the diagnostic performance of conventional ultrasound (CU) only, PHC with CU, and SR with CU. Read More

J Infrared Millim Terahertz Waves 2018 Dec 9;39(12):1283-1302. Epub 2018 Aug 9.

University of Arkansas, Fayetteville, AR 72701 USA,

This paper presents an image morphing algorithm for quantitative evaluation methodology of terahertz (THz) images of excised breast cancer tumors. Most current studies on the assessment of THz imaging rely on qualitative evaluation, and there is no established benchmark or procedure to quantify the THz imaging performance. The proposed morphing algorithm provides a tool to quantitatively align the THz image with the histopathology image. Read More

Asian J Endosc Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Surgery, Seoul National University College of Medicine, Seoul, South Korea.

Background: Near-infrared (NIR) imaging with indocyanine green (ICG)-enhanced fluorescence is widely used in laparoscopic surgery. This study aimed to evaluate this technique's feasibility and usefulness in intraoperatively assessing vascular perfusion in a laparoscopically harvested omental flap.

Materials And Surgical Techniques: From March 2015 to February 2016, we prospectively evaluated patients undergoing breast cancer surgery followed by immediate breast reconstruction using a laparoscopically harvested omental flap. Read More

Zhonghua Yi Xue Za Zhi 2019 Apr;99(14):1086-1089

Department of Breast Surgery, Affiliated Cancer Hospital of Zhengzhou University (Henan Cancer Hospital), Zhengzhou 450008, China.

To explore the preoperative evaluation of sentinel lymph node (SLN) biopsy using contrast-enhanced ultrasonography (CEUS) in early breast cancer patients and the involved disturbing factors. Eighty-three female early breast cancer patients who underwent concurrent surgery in the Affiliated Cancer Hospital of Zhengzhou University between January 2017 and May 2018 were enrolled. CEUS was used to seek SLN and determine lymph node metastasis after signature of preoperative informed consent. Read More

Radiologia 2019 Apr 10. Epub 2019 Apr 10.

Servicio de Anatomía Patológica, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Objective: To analyze the imaging characteristics of histologically diagnosed metastases to the breast.

Material And Methods: We selected patients histologically diagnosed with metastases to the breast in our diagnostic and interventional breast imaging unit between March 2010 and September 2018.

Results: A total of 9 patients (all women; mean age, 60 y; age range, 28-89 y) were diagnosed with metastases to the breast. Read More

Breast Cancer 2019 Apr 12. Epub 2019 Apr 12.

Division of Clinical Genetic Oncology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, 3-8-31 Ariake Koto-ku, Tokyo, 135-8550, Japan.

Individuals carrying pathogenic BRCA1 or BRCA2 mutations have an increased lifetime risk of breast and/or ovarian cancer. The incidence of breast cancer amongst disease-free BRCA mutation carriers under surveillance and the clinical and pathological characteristics of those who subsequently develop the disease remain unclear in Japan. We reviewed the records of 155 individuals with BRCA1 or BRCA2 mutations identified by genetic testing between January 2000 and December 2016. Read More

Med Biol Eng Comput 2019 Apr 12. Epub 2019 Apr 12.

Department of Women's Health, Research Centre for Women's Health, 72076, Tübingen, Germany.

In the case of female breast cancer, a breast-conserving excision is often desirable. This surgery is based on preoperatively gathered MRI, mammography, and sonography images. These images are recorded in multiple patient positions, e. Read More

EBioMedicine 2019 Apr 9. Epub 2019 Apr 9.

Affiliated Cancer Hospital & Institute of Guangzhou Medical University, Key Laboratory of Protein Modification and Degradation, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou 511436, China; Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China. Electronic address:

Background: It is well-established that activation of nuclear factor-kappa B (NF-κB) signaling plays important roles in cancer development and progression. However, the underlying mechanism by which the NF-κB pathway is constitutively activated in cancer remains largely unclear. The present study aimed to investigate the effect of PICALM interacting mitotic regulator (PIMREG) on sustaining NF-κB activation in breast cancer. Read More

Clin Breast Cancer 2019 Mar 11. Epub 2019 Mar 11.

Department of Breast Surgical Oncology, St Luke's International Hospital, Tokyo, Japan; Department of Breast Surgical Oncology, Watanabe Hospital, Tokyo, Japan. Electronic address:

Background: Axillary lymph node (LN) dissection after neoadjuvant chemotherapy (NAC) still remains a standard treatment of initially LN-positive primary breast cancer because of the difficulty of assessment of LN status. The aim of this study was to assess the LN status after NAC in initially LN-positive primary breast cancer patients who were assessed as clinically LN-negative after NAC (ycN0) and identify factors associated with loss of LN metastasis.

Patients And Methods: The study cohort comprised 279 patients with cytology-proven LN-positivity before NAC. Read More

BMJ 2019 Apr 10;365:l1293. Epub 2019 Apr 10.

Rochester, Kent, UK

Radiology 2019 Apr 9:182457. Epub 2019 Apr 9.

From the Departments of Medical Imaging (M.F., E.P., I.M., P.T.) and Biostatistics and Medical Information (N.M.), Montpellier University Hospital, Lapeyronie Hospital, 191 avenue du Doyen Gaston Giraud, 34295 Montpellier, France; Department of Medical Imaging, Ramsay Générale de Santé, Hospital Mermoz, Lyon, France (C.T.); Department of Women's Imaging, Centre Hospitalier de Valenciennes, Valenciennes, France (N.L.); and Department of Medical Imaging, ICM (Montpellier Cancer Institute), Montpellier, France (G.L.).

Background Combined digital mammography (DM) and digital breast tomosynthesis (DBT) (hereafter, DM plus DBT) has increased cancer detection rates when compared with those achieved with DM-only screening. However, there is limited literature on DBT as an adjunct to mammography in the staging of known breast cancers. Purpose To compare the diagnostic accuracy of DM alone with that of DM plus DBT in the identification of additional ipsilateral and contralateral lesions in women with newly diagnosed breast cancer. Read More

J Digit Imaging 2019 Apr 8. Epub 2019 Apr 8.

Voxel Imaging, Inc., 2711 N. Sepulveda Blvd., #284, Manhattan Beach, CA, 90266, USA.

The aim was to determine whether an artificial intelligence (AI)-based, computer-aided detection (CAD) software can be used to reduce false positive per image (FPPI) on mammograms as compared to an FDA-approved conventional CAD. A retrospective study was performed on a set of 250 full-field digital mammograms between January 1, 2013, and March 31, 2013, and the number of marked regions of interest of two different systems was compared for sensitivity and specificity in cancer detection. The count of false-positive marks per image (FPPI) of the two systems was also evaluated as well as the number of cases that were completely mark-free. Read More

Open Access Maced J Med Sci 2019 Mar 14;7(5):838-848. Epub 2019 Mar 14.

Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences (IUMS), Tehran, Iran.

One of the techniques utilised in the management of cancer in all stages is multiple biomedical imaging. Imaging as an important part of cancer clinical protocols can provide a variety of information about morphology, structure, metabolism and functions. Application of imaging technics together with other investigative apparatus including in fluids analysis and vitro tissue would help clinical decision-making. Read More

Diagn Interv Imaging 2019 Apr 5. Epub 2019 Apr 5.

"Diagnostic Mammography" Medical Diagnostic Imaging Unit, Kifisias Avenue 362, Chalandri, 15233 Athens, Greece. Electronic address:

Three-dimensional automated breast ultrasound system (3D ABUS) is an innovation in breast ultrasound that has been developed to uncouple detection from image acquisition and to address the limitations of handheld ultrasound (HHUS). 3D ABUS provides a large field of view using high frequency transducers, producing high-resolution images and covering a large portion of the breast with one sweep. As more data become available on breast density and the impact of supplemental screening, 3D ABUS has gained wider acceptance as an adjunct tool to mammography. Read More

Diagn Interv Imaging 2019 Apr 5. Epub 2019 Apr 5.

Department of Diagnostic and Interventional Radiology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

Although mammography is currently the imaging technique of choice for screening and diagnosis, it has some limitations, especially in patients with high-density breasts. The evolution from film screen to full-field digital mammography has recently led to the development of new imaging techniques, which are less expensive and widely available. Contrast-enhanced spectral mammography (CESM) is one of them, coupling X-ray breast imaging to the intravenous administration of an iodinated contrast material. Read More

Chin Med Sci J 2019 Mar;34(1):33-37

Department of Radiology, Hainan Hospital of Chinese PLA General Hospital, Sanya, Hainan 572013, China.

Objective To investigate the difference in texture features on diffusion weighted imaging (DWI) images between breast benign and malignant tumors.Methods Patients including 56 with mass-like breast cancer, 16 with breast fibroadenoma, and 4 with intraductal papilloma of breast treated in the Hainan Hospital of Chinese PLA General Hospital were retrospectively enrolled in this study, and allocated to the benign group (20 patients) and the malignant group (56 patients) according to the post-surgically pathological results. Texture analysis was performed on axial DWI images, and five characteristic parameters including Angular Second Moment (ASM), Contrast, Correlation, Inverse Difference Moment (IDM), and Entropy were calculated. Read More

Breast Cancer Res Treat 2019 Apr 6. Epub 2019 Apr 6.

Department of Surgery, Catharina Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, The Netherlands.

Purpose: In patients with ipsilateral breast tumor recurrence (IBTR), the detection of distant disease determines whether the intention of the treatment is curative or palliative. Therefore, adequate preoperative staging is imperative for optimal treatment planning. The aim of this study is to evaluate the impact of conventional imaging techniques, including chest X-ray and/or CT thorax-(abdomen), liver ultrasonography(US), and skeletal scintigraphy, on the distant recurrence-free interval (DRFI) in patients with IBTR, and to compare conventional imaging with F-FDG PET-CT or no imaging at all. Read More

Eur J Radiol 2019 May 4;114:192. Epub 2019 Apr 4.

Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Japan.

Anticancer Res 2019 Apr;39(4):2061-2067

Department of Surgery, Kochi Medical School, Kochi, Japan.

Background/aim: The aim of this study was to determine the natural history of benign thyroid nodules using ultrasonography.

Patients And Methods: The records of 223 patients with benign thyroid nodules treated at the Kochi Medical School from 2010 to 2012 were reviewed retrospectively. Repeated ultrasonography was performed, and the findings were directly compared with previous images. Read More

Anticancer Res 2019 Apr;39(4):1875-1882

Department of Radiology, Seoul National University College of Medicine, and Institute of Radiation Medicine, Seoul National University Medical Research Center, Seoul, Republic of Korea

Background/aim: We investigated the correlation between texture features on apparent diffusion coefficient (ADC) maps and histological vascular parameters of FN13762 rat breast cancers after antiangiogenic therapy.

Materials And Methods: FN13762 cancer cells were implanted into 30 rats, and bevacizumab was intraperitoneally administered to 15 (treated group). For each rat, magnetic resonance imaging (MRI) was obtained at five time points after baseline examination. Read More

Tissue Cell 2019 Apr 5;57:8-14. Epub 2019 Feb 5.

Arya Wellness Center, Guwahati 781032, Assam, India. Electronic address:

Fine needle aspiration cytology (FNAC) entails using a narrow gauge (25-22 G) needle to collect a sample of a lesion for microscopic examination. It allows a minimally invasive, rapid diagnosis of tissue but does not preserve its histological architecture. FNAC is commonly used for diagnosis of breast cancer, with traditional practice being based on the subjective visual assessment of the breast cytopathology cell samples under a microscope to evaluate the state of various cytological features. Read More

J Am Coll Radiol 2019 Apr;16(4 Pt B):649-656

Meharry-Vanderbilt Alliance, Nashville, Tennessee.

J Am Coll Radiol 2019 Apr;16(4 Pt B):631-634

Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.

Purpose: One in five US women report that they have been victims of intimate partner violence (IPV) during their lifetime. With millions of women presenting for mammography every year, breast imaging centers may represent ideal venues to identify women at risk for IPV and refer them to appropriate support services. Our purpose was to evaluate implementation of a novel IPV screening and referral system for women presenting for mammography. Read More

Comput Math Methods Med 2019 3;2019:2717454. Epub 2019 Mar 3.

Medical Imaging Center, Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong 518101, China.

Mammography is successfully used as an effective screening tool for cancer diagnosis. A calcification cluster on mammography is a primary sign of cancer. Early researches have proved the diagnostic value of the calcification, yet their performance is highly dependent on handcrafted image descriptors. Read More

J Breast Cancer 2019 Mar 30;22(1):67-76. Epub 2019 Jan 30.

Department of Diagnostic Radiology, Singapore General Hospital, Singapore.

Purpose: The Z0011 trial showed that axillary lymph node dissection (ALND) can be safely avoided in breast cancer patients with low nodal burden (LNB). ALND can be performed in patients with high nodal burden (HNB). We aimed to determine whether HNB in early breast cancer patients can be predicted preoperatively to avoid sentinel lymph node biopsy (SLNB). Read More

Breast Cancer 2019 Apr 1. Epub 2019 Apr 1.

Global Station for Quantum Medical Science and Engineering, Global Institution for Collaborative Research and Education, Hokkaido University, N14, W5, Kita-ku, Sapporo, 060-8648, Japan.

Background: We investigated the usefulness of the minimum ADC value of primary breast lesions for predicting axillary lymph node (LN) status in luminal A-like breast cancers with clinically negative nodes in comparison with the mean ADC.

Methods: Forty-four luminal A-like breast cancers without axillary LN metastasis at preoperative clinical evaluation, surgically resected with sentinel LN biopsy, were retrospectively studied. Mean and minimum ADC values of each lesion were measured and statistically compared between LN positive (n = 12) and LN negative (n = 32) groups. Read More

Cancer Manag Res 2019 15;11:2163-2170. Epub 2019 Mar 15.

Department of Ultrasound, Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan Province, China,

Purpose: To evaluate a classification model of contrast-enhanced ultrasound (CEUS) and examine the characteristics of patients with false-negative diagnosis.

Patients And Methods: A retrospective secondary analysis of a multicenter trial of CEUS for breast cancer diagnosis (from August 2015 to April 2017) was undertaken. Patients (n=1,023) with Breast Imaging Reporting and Data System 4-5 lesions on B-mode ultrasound underwent CEUS. Read More

AJR Am J Roentgenol 2019 Apr 1:1-7. Epub 2019 Apr 1.

9 Diagnostic Imaging, X-Ray Products, Siemens Healthcare GmbH, Forchheim, Germany.

Objective: The purpose of this study was to test the hypothesis whether two-view wide-angle digital breast tomosynthesis (DBT) can replace full-field digital mammography (FFDM) for breast cancer detection.

Subjects And Methods: In a multireader multicase study, bilateral two-view FFDM and bilateral two-view wide-angle DBT images were independently viewed for breast cancer detection in two reading sessions separated by more than 1 month. From a pool of 764 patients undergoing screening and diagnostic mammography, 330 patient-cases were selected. Read More

Br J Radiol 2019 Apr 1:20180245. Epub 2019 Apr 1.

1 Department of Radiology Faculty of Medicine, Kasr El Aini hospital, Cairo University , Egypt.

Objective:: To evaluate the clinical performance of contrast-enhanced spectral mammography (CESM) on asymmetries detected on a mammogram (MG).

Methods:: This study was approved by the Scientific Research Review Board of the Radiology Department, and waiver of informed consent was applied for the uses of data of the included cases. The study included 125 female patients,33 (26. Read More

Eur J Case Rep Intern Med 2019 22;6(3):001062. Epub 2019 Mar 22.

Hospital Distrital De Santarem E.P.E., Santarém, Portugal.

Extrapulmonary tuberculosis (TB) represents a diagnostic challenge. Bone TB is an uncommon and important presentation of extrapulmonary TB, which can lead to bone destruction, deformity and even paraplegia. Breast TB is rare and often confused with neoplasia, since the clinical and imaging presentations are not specific. Read More

Lancet Oncol 2019 Mar 28. Epub 2019 Mar 28.