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Gan To Kagaku Ryoho 2019 Jan;46(1):106-108

Dept. of Surgery, Japan Community Health care Organization(JCHO)Sagamino Hospital.

The patient was a 50-year-old woman. She had been diagnosed with bilateral breast tumors at another hospital 5 years previously and was followed up every 2 months. Ultrasonography showed hypoechoic masses in her breasts. Read More

Int J Cancer 2019 Feb 14. Epub 2019 Feb 14.

Section of Early Detection and Prevention, International Agency for Research on Cancer, 150 Cours Albert Thomas, 69372, Lyon, France.

This systematic review, stimulated by inconsistency in secondary evidence, reports the benefits and harms of breast cancer (BC) screening and their determinants according to systematic reviews. A systematic search, which identified 9,976 abstracts, led to the inclusion of 58 reviews. BC mortality reduction with screening mammography was 15-25% in trials and 28-56% in observational studies in all age groups, and the risk of stage III+ cancers was reduced for women older than 49 years. Read More

Front Chem 2019 30;7:34. Epub 2019 Jan 30.

Laboratory of Nano-Bioengineering, Moscow Engineering Physics Institute, National Research Nuclear University MEPhI, Moscow, Russia.

Imaging agents and drug carriers are commonly targeted toward cancer cell through functionalization with specific recognition molecules. Quantum dots (QDs) are fluorescent semiconductor nanocrystals whose extraordinary brightness and photostability make them attractive for direct fluorescent labeling of biomolecules or optical encoding of the membranes and cells. Here, we analyse the cytotoxicity of QD-encoded microcapsules, validate an approach to the activation of the microcapsule's surface for further functionalization with monoclonal antibody Trastuzumab, a humanized monoclonal antibody targeting the extracellular domain of the human epidermal growth factor receptor 2 (HER2) and already in clinical use for the treatment of HER2 positive breast cancer. Read More

J Cytol 2019 Jan-Mar;36(1):53-58

Department of Bioscience and Laboratory Medicine, Hirosaki University Graduate School of Health Sciences, Hirosaki, Japan.

Aim: The objective of this study was to apply a scoring method to fine needle aspiration cytology on breast duct dilatation and cystic lesions, to set an optimum cut-off value to differentiate between benign and malignant cases, and to identify features useful for cell judgment.

Materials And Methods: Samples were 23 preparations of specimens (12 benign and 11 malignant cases) suspected with intraductal lesions or cystic change by ultrasonography or mammography and cytology. The scoring system comprised the following 10 items, and each item was scored 1-3, with a total score of 10-30. Read More

J Nepal Health Res Counc 2019 Jan 28;16(41):396-400. Epub 2019 Jan 28.

Department of Radiology and Imaging, Institute of Medicine, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal.

Background: With a palpable lesion in the breast, the goal is to diagnose malignancy at the earliest. Ultrasonography is used for evaluating symptomatic patients especially those with dense breasts where mammography gives limited information. The objective of this study was to evaluate the sonographic pattern of the palpable breast lumps and correlate with the final pathological diagnosis. Read More

Clin Imaging 2019 Jan 31;55:47-52. Epub 2019 Jan 31.

Section of Breast Imaging, Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States of America. Electronic address:

Purpose: Workplace bullying has been reported in multiple medical specialties outside of diagnostic radiology within the United States. The purpose of this study was to survey diagnostic radiology residents in the United States to determine if: (1) residents had experienced bullying, (2) residents had witnessed bullying of other residents, (3) residents were aware of zero-tolerance policy for workplace bullying at their institution, (4) residents were aware of no retaliation policies for reporting bullying at their institution.

Materials And Methods: In December 2017, a weekly E-mail for 4 weeks was sent to diagnostic radiology residents in the United States (residents) who had attended the July 2017, September 2017 and October 2017 4-week American Institute for Radiologic Pathology (AIRP) resident course to participate in an online, anonymous, voluntary survey. Read More

Clin Imaging 2019 Jan 26;55:41-46. Epub 2019 Jan 26.

Ultrasound Department, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Pawińskiego 5B, 02-106, Poland.

Purpose: To evaluate the ultrasound (US) response in patients with breast cancer (BC) during neoadjuvant chemotherapy (NAC).

Methods: Prospective US analysis was performed on 19 malignant tumors prior to NAC treatment and 7 days after each first four courses of NAC in 13 patients (median age = 57 years). Echogenicity, size, vascularity, and sonoelastography were measured and compared with posttreatment scores of residual cancers burden. Read More

Phys Med 2019 Jan 9;57:137-144. Epub 2019 Jan 9.

Institut de Radioprotection et de Sûreté Nucléaire, PRP-HOM/SER/Unité d'Expertise en Radioprotection médicale, 31 avenue de la Division Leclerc, BP17, 92262 Fontenay-aux-Roses Cedex, France.

Purposes: The introduction of digital breast tomosynthesis (DBT) into the French breast cancer screening program is forecast by the authorities. The aim of the present study was to evaluate image quality phantoms to be used as internal quality controls.

Methods: Seven breast phantoms dedicated to quality control in mammography were evaluated on reconstructed DBT images: ACR Model 015, BR3D, DBT QC model 021, Mam/Digi-EPQC, MTM100, TOMOMAM® and TOMOPHAN®. Read More

J Biomed Opt 2019 Feb;24(2):1-9

Oregon Health and Science University, Department of Biomedical Engineering, Portland, Oregon, United States.

Intraoperative margin assessment is imperative to cancer cure but is a continued challenge to successful surgery. Breast conserving surgery is a relevant example, where a cosmetically improved outcome is gained over mastectomy, but re-excision is required in >25  %   of cases due to positive or closely involved margins. Clinical translation of margin assessment modalities that must directly contact the patient or required administered contrast agents are time consuming and costly to move from bench to bedside. Read More

J Clin Ultrasound 2019 Feb 8. Epub 2019 Feb 8.

Cedar Breast Clinic, McGill University Health Center, Royal Victoria Hospital, Montreal, Québec, Canada.

Purpose: To evaluate strain elastography as a complementary tool for characterization of lesions identified during second-look MRI-directed sonographic examination.

Methods: We reviewed 83 breast lesions evaluated with MRI, secondlook ultrasound (US) and strain elastography in 75 consecutive patients (median age, 56 years). US-guided biopsies were performed in all cases. Read More

J Nucl Med 2019 Feb 7. Epub 2019 Feb 7.

Hunter College of the City University of New York, United States.

Antibodies are promising vectors for positron-emission tomography (PET) imaging. However, the high uptake of radioimmunoconjugates in non-target tissues such as the liver and spleen hampers their performance as radiotracers. This off-target uptake can lead to suboptimal tumor-to-background activity concentration ratios, decreasing the contrast of images and reducing their diagnostic utility. Read More

Clin Breast Cancer 2018 Dec 7. Epub 2018 Dec 7.

UOC Radiologia, UOS di Senologia Interventistica, Policlinico Tor Vergata: Fondazione PTV, Università di Roma "Tor Vergata", Roma, Italy.

Background: The study aimed to evaluate the feasibility and reliability of ultrasound-guided vacuum-assisted breast biopsy (US-VABB) for sampling of microcalcifications indicative of cancer when stereotactic vacuum-assisted breast biopsy cannot be performed because of reasons such as thin breast tissue, insufficient thickness at compression, and microcalcification situated close to the chest wall or in breast tissue of the axillary tail.

Patients And Methods: The study population was selected from among 187 patients with microcalcifications detected on mammogram. The findings were classified using the American College of Radiology criteria as Breast Imaging Reporting and Data System 3, 4, or 5. Read More

Eur J Surg Oncol 2019 Jan 14. Epub 2019 Jan 14.

Department of Surgical Oncology, Maastricht University Medical Centre, Maastricht, the Netherlands; GROW - School for Oncology and Developmental Biology, Maastricht University Medical Centre, the Netherlands.

Introduction: Imaging findings can be affected by histopathological characteristics, such as breast cancer subtypes. The aim was to determine whether the diagnostic performance, in particular negative predictive value (NPV), of axillary US differs per subtype of breast cancer.

Methods: All patients diagnosed between 2008 and 2016 in our hospital with primary invasive breast cancer and an axillary US prior to axillary surgery were included. Read More

MAGMA 2019 Feb 7. Epub 2019 Feb 7.

Biomaterials Group, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, 1417614411, Tehran, Iran.

Objectives: In this study, a novel targeted MRI contrast agent was developed by coating gadolinium oxide nanoparticles (GdO NPs) with β-cyclodextrin (CD)-based polyester and targeted by folic acid (FA).

Materials And Methods: The developed GdO@PCD-FA MRI contrast agent was characterized and evaluated in relaxivity, in vitro cell targeting, cell toxicity, blood compatibility and in vivo tumor MR contrast enhancement.

Results: In vitro cytotoxicity and hemolysis assays revealed that GdO@PCD-FA NPs have no significant cytotoxicity after 24 and 48 h against normal human breast cell line (MCF-10A) at concentration of up to 50 µg Gd/mL and have high blood compatibility at concentration of up to 500 µg Gd/mL. Read More

Breast Cancer Res Treat 2019 Feb 6. Epub 2019 Feb 6.

Center of Familial Breast and Ovarian Cancer, University Hospital Cologne, Cologne, Germany.

Purpose: To report on 10 years of high-risk service screening with annual MRI in the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC).

Methods: A cohort of 4,573 high-risk, previously unaffected women (954 BRCA1 carriers, 598 BRCA2 carriers, 3021 BRCA1/2 non-carriers) participating in the GC-HBOC surveillance program was prospectively followed. Screening outcomes for 14,142 screening rounds with MRI between 2006 and 2015 were analyzed and stratified by risk group, type of screening round, and age. Read More

J Gene Med 2019 Feb 4:e3075. Epub 2019 Feb 4.

Department of Ultrasonography, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

Purpose: Sentinel lymph node (SLN) property assessment (with or without metastasis) is important while deciding the surgery for breast cancer; however, the current diagnosis of SLN metastasis remains to be studied. microRNAs (miRNAs) have been previously confirmed as a molecular marker for the diagnosis, development, and prognosis of tumors. However, the detailed role of miRNAs in the diagnosis of SLN metastasis has not been reported. Read More

Clin Hemorheol Microcirc 2019 Jan 29. Epub 2019 Jan 29.

Department of Radiology and Interdisciplinary Ultrasound Centre and Ultrasound Research Laboratory, University Berlin, Charité, Berlin, Germany.

Background: Besides mammography, breast ultrasound is the most important imaging modality for women with suspected breast cancer. New software tools bear high potential for improved detectability and specification of malignant breast lesions.

Objective: To compare the halo depicted around malignant breast lesions by ultrasound using Acoustic Structure Quantification (ASQ) of raw image data with the echogenic rim seen in B-mode ultrasound. Read More

Breast J 2019 Feb 3. Epub 2019 Feb 3.

Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu, South Korea.

To evaluate predictive factors for residual metastatic axillary lymph node (ALN) disease in patients with negative imaging findings after neo-adjuvant chemotherapy (NAC) for breast cancer. From January 2011 to December 2015, 206 patients underwent imaging including ultrasonography, MRI, and PET/CT for restaging the axilla after NAC. Data collected included preoperative information regarding histologic grade, hormone receptor (HR) status, and human epidermal growth factor receptor 2 (HER2) status. Read More

Indian J Nucl Med 2019 Jan-Mar;34(1):1-9

Department of Oncology and Nuclear Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Aim: This study aims to assess the diagnostic performance of F-fluorodeoxyglucose-positron emission tomography/computerized tomography (FDG-PET/CT) compared to whole body (WB) magnetic resonance diffusion-weighted imaging (DWI) with background body signal suppression (MR/DWIBS) in lesions detection in patients with recurrent breast cancer.

Materials And Methods: Twenty-three female patients with suspected breast cancer recurrence by clinical, laboratory, or conventional imaging underwent both FDG-PET/CT and WB MR/DWIBS. WB FDG-PET/CT was performed using the standard technique. Read More

Intern Med 2019 Feb 1. Epub 2019 Feb 1.

Department of Breast and Medical Oncology, National Cancer Center Hospital, Japan.

Objective Few reports have analyzed the diagnostic process of carcinoma of unknown primary site (CUP) or have focused on the frequency of nonmalignant lesions among patients with suspected malignant diseases. The aim of this study was to investigate the incidence and characteristics of nonmalignant diseases that tend to be mistaken for malignant diseases. Patients We retrospectively analyzed the medical records of patients with suspected CUP who were referred to the National Cancer Center Hospital (Tokyo, Japan) between April 2007 and December 2014. Read More

Anticancer Res 2019 02;39(2):915-921

Department of Breast and Endocrine Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Background/aim: To clarify the diagnostic utility of third-look, contrast-enhanced ultrasonography (CEUS) for MRI-detected breast lesions undetectable by unenhanced, second-look ultrasonography (MRI+/US- lesions).

Patients And Methods: Clinical stage 0-IIA breast cancer patients who underwent CEUS for incidental MRI+/US- lesions (n=27; cohort 1) and patients with breast lesions detected only by MRI, to be examined by CEUS (n=15; cohort 2), were retrospectively analyzed.

Results: Of the 42 MRI+/US- lesions, 23 (55%) were detected by CEUS and then examined by needle biopsy. Read More

Acad Radiol 2018 Jul 31. Epub 2018 Jul 31.

University of Texas, Department of Diagnostic Radiology, MD Anderson Cancer Center, Houston, TX 77030-4009.

Burnout is a global health problem affecting physicians across all medical specialties. Radiologists, in particular, experience high rates of burn out, and this trend has only continued to worsen. The "Promoting Health and Wellness for Radiologists Task Force of the Association of University Radiologists-Radiology Research Alliance" presents a review of the prevalence, causes, and impact of burnout among radiology faculty and trainees, and a discussion on strategies for overcoming burnout and promoting overall health and well-being among radiologists. Read More

Clin Radiol 2019 Jan 29. Epub 2019 Jan 29.

Diagnostic and Interventional Imaging, KK Women's and Children's Hospital, 100 Bukit Timah Road, 229 899, Singapore.

Aim: To define the computed tomography (CT) features common in skeletal muscle metastases and their prevalence and to identify the most commonly associated primary malignancy and the most common muscle groups in which skeletal muscle metastases are found.

Methods And Materials: Institutional review board (IRB) waiver for informed consent was obtained. A retrospective review was conducted of CT examinations from a single, large, academic centre picture archiving and communication system (PACS) database, performed from August 2009 to July 2013. Read More

Cancer Imaging 2019 Feb 1;19(1). Epub 2019 Feb 1.

Department of Radiology, School of Medicine, Kyungpook National University, Kyungpook National University Hospital, Daegu, South Korea.

Background: Although the role of axillary imaging has been redirected for predicting high nodal burden rather than predicting nodal metastases since ACOSOG Z1011 trial, it remains unclear whether and how axillary lymph node (ALN) characteristics predicts high nodal burden. Our study was aimed to evaluate the predictive value of imaging characteristics of ALNs at ultrasound and magnetic resonance imaging (MRI) for prediction of high nodal burden (≥3 metastatic ALNs) in clinically node-negative breast cancer patients.

Methods: Clinicopathological and imaging characteristics were evaluated in patients with ultrasound (n = 312) and MRI (n = 256). Read More

J Med Imaging Radiat Oncol 2019 Feb 1. Epub 2019 Feb 1.

Medical Radiation Sciences, Faculty of Health Sciences, The University of Sydney, Lidcombe, New South Wales, Australia.

Introduction: Differences in radiologists' experience can potentially introduce interobserver variability in reading mammograms. This work investigated the effect of radiologists' experience on agreement on mammographic final classification.

Methods: This was a cross-sectional study. Read More

J Digit Imaging 2019 Jan 31. Epub 2019 Jan 31.

Department of Medical Physics, Columbia University Medical Center, 177 Ft. Washington Ave., Milstein Bldg Room 3-124B, New York, NY, 10032-3784, USA.

To develop a convolutional neural network (CNN) algorithm that can predict the molecular subtype of a breast cancer based on MRI features. An IRB-approved study was performed in 216 patients with available pre-treatment MRIs and immunohistochemical staining pathology data. First post-contrast MRI images were used for 3D segmentation using 3D slicer. Read More

Asia Ocean J Nucl Med Biol 2019 ;7(1):13-21

Department of Nuclear Medicine and Tracer Kinetics, Osaka University, Graduate School of Medicine, Osaka, Japan.

Objectives: To investigate the diagnostic accuracy of positron emission mammography (PEM) and positron emission tomography/computed tomography (PET/CT) for small breast tumors of less than 20 mm in size.

Methods: The study was conducted on a total of 100 subjects (i.e. Read More

Breast Cancer Res 2019 Jan 31;21(1):19. Epub 2019 Jan 31.

Department of Internal Medicine III with Hematology, Medical Oncology, Hemostaseology, Infectiology and Rheumatology, Oncologic Center; Salzburg Cancer Research Institute - Laboratory for Immunological and Molecular Cancer Research (SCRI-LIMCR), Paracelsus Medical University, Salzburg, Austria.

Background: Patients with early breast cancer (EBC) achieving pathologic complete response (pCR) after neoadjuvant chemotherapy (NACT) have a favorable prognosis. Breast surgery might be avoided in patients in whom the presence of residual tumor can be ruled out with high confidence. Here, we investigated the diagnostic accuracy of contrast-enhanced MRI (CE-MRI) in predicting pCR and long-term outcome after NACT. Read More

Clin Imaging 2019 Jan 17;55:12-17. Epub 2019 Jan 17.

Department of Radiology, Korea University Guro Hospital, Republic of Korea.

Purpose: Currently in diagnostic setting for breast cancer, FFDM and DBT are performed conjunctively. However, performing two imaging modalities may increase radiation exposure by double. Two-dimensional reconstructed images created from DBT with 2DSM, has a potential to replace conventional FFDM in concerning both radiation dosage and image quality. Read More

Cancer Manag Res 2019 17;11:813-819. Epub 2019 Jan 17.

Department of Ultrasound, Dongguan People's Hospital, Dongguan, Guangdong 523000, China,

Introduction: This research was conducted to explore the relationship between the systemic immune-inflammation index (SII) and breast imaging-reporting and data system (BI-RADS) classification using ultrasonography and the survival of patients with triple-negative breast cancer (TNBC) in a cohort of Chinese.

Methods: A total of 215 TNBC patients treated at our hospital between November 2008 and March 2016 were enrolled in this study. We used the log-rank test and Kaplan-Meier curves to assess the overall survival (OS) and disease-free survival (DFS) differences between groups. Read More

BMJ Case Rep 2019 Jan 28;12(1). Epub 2019 Jan 28.

Anesthesiology and Reanimation, Muğla Sıtkı Koçman University, Muğla, Turkey.

The use of ultrasound guidance increases the safety of peripheral block interventions by allowing anaesthesiologists to simultaneously see the position of block needle, the targeted nerves and surrounding vessels. In this report, we represented three patients diagnosed with double axillary vein variation with ultrasound guidance during infraclavicular nerve block intervention. The patients were scheduled for different types of upper limb surgeries. Read More

Radiology 2019 Jan 29:182082. Epub 2019 Jan 29.

From the Department of Radiology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit St, Boston, MA 02141 (R.C.M.); Rhode Island Hospital, Providence, RI (G.L.B., E.H.D.); Department of Diagnostic Imaging, Alpert Medical School, Brown University, Providence, RI (G.L.B., E.H.D.); Department of Radiology, Tufts University School of Medicine, Boston, Mass (P.C.); The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, Md (E.F.); Department of Internal Medicine, University of California, San Francisco, San Francisco, Calif (M.G.); and San Francisco VA Medical Center, San Francisco, Calif (M.G.).

Purpose To evaluate readability of websites that are commonly accessed for information on breast lesions requiring surgery. Materials and Methods An internet search using three malignant and eight nonmalignant breast lesions that traditionally require lumpectomy or excisional biopsy as search terms was conducted to identify websites commonly accessed for patient information on breast lesions requiring surgery. Nine websites with information on breast diagnoses were identified based on search engine results for each breast lesion queried. Read More

J Magn Reson Imaging 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, NYU School of Medicine, New York, New York, USA.

Contrast-enhanced breast MRI is a standard evidence-based component of supplemental screening in conjunction with mammography for higher-risk populations because of its high sensitivity for detecting breast cancer; the use of breast MRI for screening in high-risk populations is recommended in multiple national and international guidelines. The current MRI exam, however, is expensive relative to other screening technologies such as mammography, and relatively more time-intensive. Recent investigations have focused on techniques that have the potential for improving efficiency of the breast MRI exam, decreasing acquisition and reading times, without impacting diagnostic accuracy. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2479-2481

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

We diagnosed invasive breast ductal cancer in a 42-year-old woman. About 10 years previously, she noticed an abnormal nipple discharge, and core needle biopsy indicated intraductal papilloma of the breast. However, the secretion continued, and we performed core needle biopsy again, which suggested invasive breast ductal cancer. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2432-2434

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

A 73-year-old woman visited our hospital with the chief complaint of a mass in the left breast. Breast ultrasonography revealed a hypoechoic area in the left breast. A core needle biopsy showed the proliferation of solid tumor cells. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1904-1906

Division of Breast and Endocrine Surgery, Dept. of Surgery, Nihon University School of Medicine.

Neuroendocrine carcinoma(NEC)is a rare disease. We report a case of NEC encountered in the general hospital without a breast department. The patient was a 69-year-old woman. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1857-1859

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

History of male breast cancer and pancreatic cancer are important for diagnosis of hereditary breast and ovarian cancer syndrome(HBOC), while advanced pancreatic cancer is reported to have metastasis to mammary gland tissue. A 67-year-old man visited a local hospital because fever and right hypochondrial pain. Computed tomography scan revealed pancreatic cancer with multiple liver metastasis and peritoneal metastasis. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1842-1844

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

Paget's disease of the breast is usually localized in the nipple epidermis and lactiferous duct located near the nipple. Here, we report a rare case of synchronous breast carcinoma with Paget's disease and invasive ductal carcinoma. A 50-year-old woman was admitted to our hospital because of abnormalities in screening mammography findings. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):2217-2219

Dept. of Surgery, Baba Memorial Hospital.

A 61-year-old woman with a breast tumor detected by mammography examination was admitted to our hospital. Ultrasonography showed a 15.5×7. Read More

Eur J Radiol 2019 Feb 30;111:76-80. Epub 2018 Dec 30.

Department of Medical Oncology, Mansoura Faculty of Medicine, Mansoura, 13551, Egypt. Electronic address:

Aim Of The Work: To investigate mean diffusivity (MD) and fractional anisotropy (FA) measured by diffusion tensor imaging (DTI) as complementary tools to differentiate recurrent breast cancer from post-operative changes in patients with breast-conserving surgery (BCS).

Patients And Methods: Prospective study was conducted upon 30 patients with BCS that underwent DTI and dynamic contrast MR imaging. DTI was performed using an axial two-dimensional spin-echo echo-planar imaging sequence. Read More

Eur J Radiol 2019 Feb 14;111:6-13. Epub 2018 Dec 14.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, Germany.

Introduction: To investigate the utility of quantitative dual-energy spectral CT derived iodine concentration (IC), in comparison with conventional CT attenuation, for the differentiation of pulmonary metastases from different primary malignancies.

Materials And Methods: CT scans were performed on a dual-layer spectral CT. We retrospectively evaluated pulmonary metastases of 130 patients (77 men and 53 women, mean age 63, range 22-87) with primary bone (OS) (osteosarcoma; n = 6), breast (invasive-ductal adenocarcinoma; n = 17), colorectal (CRC) (adenocarcinoma; n = 27), head and neck (HNC) (squamous cell carcinoma; n = 17), kidney (RCC) (clear-cell renal cell carcinoma; n = 10), lung (adenocarcinoma; n = 12), pancreato-biliary (PBC) (adenocarcinoma; n = 18), prostate (adenocarcinoma; n = 5), soft tissue (undifferentiated pleomorphic sarcoma; n = 6), skin (malignant melanoma; n = 6), and urinary tract (transitional-cell carcinoma; n = 6) malignancies. Read More

Annu Rev Med 2019 Jan;70:501-519

Department of Diagnostic and Interventional Radiology, RWTH Aachen University, 52074 Aachen, Germany; email:

Given the increasing understanding of cancer as a heterogeneous group of diseases, detection methods should offer a sensitivity profile that ensures perfect sensitivity for biologically important cancers while screening out self-limiting pseudocancers. However, mammographic screening is biased toward detection of ductal carcinoma in situ and slowly growing cancers-and thus frequently fails to detect biologically aggressive cancers. This explains the persistently high rates of interval cancers and high rates of breast cancer mortality observed in spite of decades of mammographic screening. Read More

Eur Radiol 2019 Jan 28. Epub 2019 Jan 28.

Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.

Purpose: To develop and optimize a rapid magnetic resonance imaging (MRI) screening protocol for pancreatic cancer to be performed in conjunction with breast MRI screening in breast cancer susceptibility gene (BRCA)-positive individuals.

Methods: An IRB-approved prospective study was conducted. The rapid screening pancreatic MR protocol was designed to be less than 10 min to be performed after a standard breast MRI protocol. Read More

Gland Surg 2018 Dec;7(6):554-559

Diagnostic Radiology, Mount Elizabeth Novena Hospital, Singapore.

Breast conservation surgery (BCS) is offered for early breast cancer. Conventional imaging with mammography and ultrasound would have been performed prior to surgery. This article considers other imaging modalities available [such as 3D tomosynthesis, magnetic resonance imaging (MRI), contrast-enhanced spectral mammography, positron emission mammography (PEM), breast-specific gamma imaging (BSGI) and cone beam computed tomography (CBCT)] and discusses the evidence for these in terms of diagnostic accuracy and clinical outcomes. Read More

Dig Liver Dis 2019 Jan 9. Epub 2019 Jan 9.

Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. Electronic address:

Background: Growing evidence supports that nonalcoholic fatty liver disease (NAFLD) is associated with extrahepatic cancers. Nonalcoholic fatty liver disease (NAFLD) and breast cancer share similar risk factors, including obesity.

Aim: The aim of this case-control study was to investigate the association between NAFLD and breast cancer. Read More

J Am Coll Radiol 2019 Jan 24. Epub 2019 Jan 24.

Department of Diagnostic Imaging, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, Rhode Island.

Purpose: To evaluate grade-level readability of dense breast notification letters (DBNs) and popular websites.

Methods: HIPAA-compliant, institutional review board-exempt study. As of April 2018, letter characteristics and grade-level readability were evaluated from states with mandated text using five readability metrics, one of which was the Flesch-Kincaid Grade Level. Read More

Curr Probl Cancer 2019 Jan 23. Epub 2019 Jan 23.

King Hamad Hematology-Oncology Center, Department of Medical Oncology, Bahrain.

Aim: The positive energy balance and insulin resistance caused by weight gain, physical inactivity, poor dietary quality are linked to a decreased breast cancer (BC)-specific survival. The aim of the present study was to assess whether or not hepatosteatosis, which reflect underlying insulin resistance, has a predictive value on recurrence in patients with nonmetastatic BC.

Material Method: All diagnosed nonmetastatic BC patients between 2005 and 2016 were included in this retrospective analysis. Read More

Medicine (Baltimore) 2019 Jan;98(4):e14258

Objective: Recent reports have suggested that contrast-enhanced ultrasound (CEUS) can be used to monitor the pathologic responses of breast cancer (BC) to neoadjuvant chemotherapy (NAC); however, the diagnostic performance of CEUS in BC has yet to be confirmed. Thus, we conducted a meta-analysis of related studies to explore the relationship between CEUS and pathologic responses of BC to NAC.

Materials And Methods: We searched PubMed, Embase, Web of Science, ScienceDirect, and China National Knowledge Infrastructure databases for studies published until September 31, 2018. Read More

Pattern Recognit 2018 Dec 20;84:345-356. Epub 2018 Jul 20.

Department of Medicine, University of Washington, Seattle, WA 98195, USA.

Generalizability of algorithms for binary cancer vs. no cancer classification is unknown for clinically more significant multi-class scenarios where intermediate categories have different risk factors and treatment strategies. We present a system that classifies whole slide images (WSI) of breast biopsies into five diagnostic categories. Read More

Rev Esp Med Nucl Imagen Mol 2019 Jan 21. Epub 2019 Jan 21.

Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil. Electronic address:

Objective: Breast cancer is a health problem worldwide with high incidence and mortality rates. It is well known that the development of more sensitive and specific diagnostic methods is of great importance since an early diagnosis is essential to successfully treat tumors. Lapachol is a natural compound, belonging to the naphthoquinone group that has been widely used in traditional medicine to treat various illnesses, including cancer. Read More