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    Molecular imaging of cardiac remodelling after myocardial infarction.
    Basic Res Cardiol 2018 Jan 17;113(2):10. Epub 2018 Jan 17.
    School of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas Hospital, 4th Floor, Lambeth Wing, London, SE1 7EH, UK.
    Myocardial infarction and subsequent heart failure is a major health burden associated with significant mortality and morbidity in western societies. The ability of cardiac tissue to recover after myocardial infarction is affected by numerous complex cellular and molecular pathways. Unbalance or failure of these pathways can lead to adverse remodelling of the heart and poor prognosis. Read More

    Post-mortem MR angiography: quantitative investigation and intravascular retention of perfusates in ex situ porcine hearts.
    Int J Legal Med 2018 Jan 18. Epub 2018 Jan 18.
    Institute of Medical Engineering, Graz University of Technology, Graz, Austria.
    As the implementation of minimally invasive imaging techniques in both forensic and pathological practice increases, research in this area focuses on addressing recognised diagnostic weaknesses of current approaches. Assessment of sudden cardiac death (SCD) can be considered one such area in which post-mortem imaging still shows diagnostic weaknesses. We hypothesise that magnetic resonance imaging (MRI) with an angiographic adjunct may improve the visualisation and interpretation of cardiac pathologies in a post-mortem setting. Read More

    Limb-bud and Heart Overexpression Inhibits the Proliferation and Migration of PC3M Cells.
    J Cancer 2018 1;9(2):424-432. Epub 2018 Jan 1.
    State Key Laboratory of Oncology in South China, Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, Guangzhou 510660, China.
    Background: The limb-bud and heart gene (LBH) was discovered in the early 21st century and is specifically expressed in the mouse embryonic limb and heart development. Increasing evidences have indicated that LBH not only plays an important role in embryo development, it is also closely correlated with the occurance and progression of many tumors. However, its function in prostate cancer (PCa) is still not well understood. Read More

    A patient with chronic myeloid leukemia and situs inversus totalis: A case report.
    Oncol Lett 2017 Dec 10;14(6):7425-7430. Epub 2017 Oct 10.
    Department of Hematology, The First Affiliated Hospital, Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
    In the present study, a case of chronic myeloid leukemia (CML) with complete situs inversus in a 68-year-old female patient was reported. The patient presented with general weakness, abdominal distension and tenderness in the right hypochondrium. A chest X-ray revealed a right-sided heart. Read More

    Noninvasive quantification of left-to-right shunt by phase contrast magnetic resonance imaging in secundum atrial septal defect: the effects of breath holding and comparison with invasive oximetry.
    Int J Cardiovasc Imaging 2018 Jan 16. Epub 2018 Jan 16.
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
    To investigate the effect of breath-holding on left-to-right shunts in patients with a secundum atrial septal defect (ASD). Thirty-five consecutive patients with secundum ASDs underwent right heart catheterization and invasive oximetry. Phase-contrast magnetic resonance imaging (MRI) was performed for the main pulmonary artery and ascending aorta. Read More

    Clinical Value of Ultrasonography in Diagnosis of Pulmonary Embolism in Critically Ill Patients.
    J Transl Int Med 2017 Dec 29;5(4):200-204. Epub 2017 Dec 29.
    Department of Critical Care Medicine, the First Affiliated Hospital of China Medical University, Shenyang110001, Liaoning Province, China.
    Pulmonary embolism (PE) is a clinical emergency that will increase the mortality if complicated with unstable hemodynamics. Because of its nonspecific clinical symptoms, it's a great challenge to make a PE diagnosis. The golden standard to diagnose PE is computed tomography of pulmonary artery (CTPA), but a diagnosis of PE also composed of evaluation of PE risk factors, possibilities, and risk stratification. Read More

    High-Target vs Low-Target Blood Pressure Management During Cardiopulmonary Bypass to Prevent Cerebral Injury in Cardiac Surgery Patients - A Randomized Controlled Trial.
    Circulation 2018 Jan 16. Epub 2018 Jan 16.
    Department of Cardiothoracic Anesthesia, The Heart Centre, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
    Background -Cerebral injury is an important complication following cardiac surgery with the use of cardiopulmonary bypass (CPB). The rate of overt stroke after cardiac surgery is 1-2%, whereas silent strokes, detected by diffusion-weighed magnetic resonance imaging (DWI), are found in up to 50% of patients. It is unclear if a higher versus a lower blood pressure during cardiopulmonary bypass reduces cerebral infarction in these patients. Read More

    Improved coronary magnetic resonance angiography using gadobenate dimeglumine in pediatric congenital heart disease.
    Magn Reson Imaging 2018 Jan 12. Epub 2018 Jan 12.
    Division of Imaging Sciences & Biomedical Engineering, King's College London, London, UK; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA. Electronic address:
    Background: CMRA in pediatrics remains challenging due to the smaller vessel size, high heart rates (HR), potential image degradation caused by limited patient cooperation and long acquisition times. High-relaxivity contrast agents have been shown to improve coronary imaging in adults, but limited data is available in children. We sought to investigate whether gadobenate dimeglumine (Gd-BOPTA) together with self-navigated inversion-prepared coronary magnetic resonance angiography (CMRA) sequence design improves coronary image quality in pediatric patients. Read More

    Coronary and arch hybrid surgery in a patient with infrarenal aortic occlusion.
    Asian Cardiovasc Thorac Ann 2018 Jan 1:218492318755181. Epub 2018 Jan 1.
    1 Department of Surgery, Yong Loo Lin School of Medicine, 37580 National University of Singapore, Singapore.
    A 65-year-old gentleman with claudication underwent contrast-enhanced computed tomography. The scan showed occlusion of the infrarenal abdominal aorta and a 6.0 × 3. Read More

    Incidental Pulmonary Nodules Are Common on CT Coronary Angiogram and Have a Significant Cost Impact.
    Heart Lung Circ 2017 Dec 5. Epub 2017 Dec 5.
    Monash Lung and Sleep, Monash Health, Melbourne, Vic, Australia. Electronic address:
    Background: Computed tomography (CT) coronary angiogram (CTCA) is commonly used for diagnostic evaluation of low-moderate risk patients due to its excellent performance and cost-effectiveness. However, previous cost analyses have not factored in the burden of management of pulmonary nodules, which are a common occurrence. We sought to describe the frequency and characteristics of lung nodules on CTCA in an Australian tertiary hospital, and to assess cost impacts. Read More

    Hybrid Imaging in Ischemic Heart Disease.
    Rev Esp Cardiol (Engl Ed) 2018 Jan 9. Epub 2018 Jan 9.
    Department of Nuclear Medicine, Cardiac Imaging, University Hospital Zurich, Zurich, Switzerland. Electronic address:
    Hybrid imaging for ischemic heart disease refers to the fusion of information from a single or usually from multiple cardiovascular imaging modalities enabling synergistic assessment of the presence, the extent, and the severity of coronary atherosclerotic disease along with the hemodynamic significance of lesions and/or with evaluation of the myocardial function. A combination of coronary computed tomography angiography with myocardial perfusion imaging, such as single-photon emission computed tomography and positron emission tomography, has been adopted in several centers and implemented in international coronary artery disease management guidelines. Interest has increased in novel hybrid methods including coronary computed tomography angiography-derived fractional flow reserve and computed tomography perfusion and these techniques hold promise for the imminent diagnostic and management approaches of patients with coronary artery disease. Read More

    Multimodality imaging evaluation before transcatheter aortic valve implantation: incidence of contrast medium-induced acute kidney injury, risk factors and prognosis.
    Clin Radiol 2018 Jan 10. Epub 2018 Jan 10.
    Department of Diagnostic and Interventional Radiology, University Hospital Giessen, Giessen, Germany.
    Aim: To evaluate the incidence, risk factors, and prognostic implications of contrast medium-induced acute kidney injury (CI-AKI) in patients undergoing transcatheter aortic valve implantation (TAVI) evaluation.

    Materials And Methods: Datasets from 98 out of 207 consecutive patients referred for multidetector computed tomography (MDCT) for TAVI evaluation were eligible for evaluation and were analysed retrospectively. The incidence of CI-AKI was correlated to outcome and to potential risk factors: kidney function (estimated glomerular filtration rate [eGFR]), heart failure, diabetes, amount of contrast medium, and duration of examination period. Read More

    The gas bubble sign - a reliable indicator of laryngeal fractures in hanging on postmortem computed tomography.
    Br J Radiol 2018 Jan 12:20170479. Epub 2018 Jan 12.
    1 Institute of Forensic Medicine and Imaging, University of Zurich, Zurich, Switzerland.
    Objective: The purpose was to evaluate the presence of gas in the tissue adjacent to the laryngeal structures, "the gas bubble sign", in cases of hanging as a diagnostic indicator of neck trauma.

    Methods: In this study, postmortem computed tomography scans and autopsies of 35 victims of hanging were examined to reveal age-dependent changes, laryngeal fracture, fracture location, and the presence of gas. A matched group with cardiac arrest or intoxication was used as controls (n = 35). Read More

    Arms Down Cone Beam CT Hepatic Angiography Performance Assessment: Vascular Imaging Quality and Imaging Artifacts.
    Cardiovasc Intervent Radiol 2018 Jan 11. Epub 2018 Jan 11.
    Department of Radiology, Interventional Radiology Service, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA.
    Introduction: The practice of positioning patients' arms above the head during catheter-injected hepatic arterial phase cone beam CT (A-CBCT) imaging has been inherited from standard CT imaging due to image quality concerns, but interrupts workflow and extends procedure time. We sought to assess A-CBCT image quality and artifacts with arms extended above the head versus down by the side.

    Methods: We performed an IRB approved retrospective evaluation of reformatted and 3D-volume rendered images from 91 consecutive A-CBCTs (43 arms up, 48 arms down) acquired during hepatic tumor arterial embolization procedures. Read More

    Age, Sex, and Gene Expression Score identifies a symptomatic, nondiabetic male patient as being at high risk of obstructive coronary artery disease.
    SAGE Open Med Case Rep 2018 4;6:2050313X17749081. Epub 2018 Jan 4.
    Berks Cardiologists, Ltd, Wyomissing, PA, USA.
    In October 2015, a 74-year-old Caucasian male patient (past medical history of hyperlipidemia, paroxysmal atrial fibrillation, hypertension, and hypothyroidism) presented to the cardiologist for follow-up outpatient evaluation of exertional chest pain. The patient had recently been seen at the Emergency Department for the same complaint. At that time, the patient's cardiac markers, EKG, and pharmacological nuclear stress testing were all reported as normal. Read More

    [Risk factors and impacts on prognosis of ultrasound lung comets in patients undergoing hemodialysis].
    Zhonghua Yi Xue Za Zhi 2017 Dec;97(48):3796-3801
    Department of Nephrology, Laiwu Municipal People's Hospital, Laiwu 271100, China.
    Objective: To investigate the risk factors of ultrasound lung comets and its impact on the survivals of patients undergoing hemodialysis. Methods: One hundred and forty-two patients on hemodialysis (Male 76, female 66) were divided into three groups according to the score of lung comets (mild: ≤14 comets; moderate: 15 to 30 comets; severe: >30 comets). Seventy-two healthy subjects examined by lung ultrasound serve as a control. Read More

    [Functional diagnostics in pneumology].
    Internist (Berl) 2018 Jan;59(1):15-24
    Innere Medizin, Klinikum Würzburg Mitte - Standort Missioklinik, Salvatorstr. 7, 97064, Würzburg, Deutschland.
    Alongside imaging techniques, pulmonary function testing helps in the diagnosis of underlying disorders such as asthma and chronic obstructive pulmonary disease (COPD) or fibrosing lung disease. However, disease severity grading is also important, as well as disease follow-up under therapy. The value of spirometry as a first-line diagnostic test, whole-body plethysmography in advanced diagnostics, the measurement of transfer factor, as well as blood gas analysis are outlined. Read More

    Cardiac Sarcoidosis Concomitant with Large-vessel Aortitis Detected by 18F-fluorodeoxyglucose Positron Emission Tomography.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Internal Medicine, Kyushu University Beppu Hospital, Japan.
    We herein report a case of concurrent cardiac sarcoidosis and large-vessel aortitis detected by 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) and followed up during immunosuppressive therapy. After high-dose prednisolone administration (1 mg/kg), serial FDG-PET showed that almost all of the abnormal FDG uptake in the heart and extracardiac region, including the abdominal to bilateral iliac arteries, had been disappeared. During the tapering of prednisolone, additive methotrexate therapy was needed to treat the recurrence of cardiac sarcoidosis. Read More

    Diagnostic and prognostic utility of cardiovascular magnetic resonance imaging in heart failure with preserved ejection fraction - implications for clinical trials.
    J Cardiovasc Magn Reson 2018 Jan 11;20(1). Epub 2018 Jan 11.
    Department of Cardiovascular Sciences and National Institute for Health Research (NIHR), University of Leicester, Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Groby Road, Leicester, LE3 9QP, UK.
    Background: Heart failure with preserved ejection fraction (HFpEF) is a poorly characterized condition. We aimed to phenotype patients with HFpEF using multiparametric stress cardiovascular magnetic resonance imaging (CMR) and to assess the relationship to clinical outcomes.

    Methods: One hundred and fifty four patients (51% male, mean age 72 ± 10 years) with a diagnosis of HFpEF underwent transthoracic echocardiography and CMR during a single study visit. Read More

    Diagnostic performance of static single-scan stress perfusion cardiac computed tomography in detecting hemodynamically significant coronary artery stenosis: a comparison with combined invasive coronary angiography and cardiovascular magnetic resonance-myocardial perfusion imaging.
    Acta Radiol 2018 Jan 1:284185117752553. Epub 2018 Jan 1.
    1 Departments of Radiology, 58933 Konkuk University Medical Center, Konkuk University School of Medicine , Seoul, Republic of Korea.
    Background Non-invasive anatomical and physiological evaluations of coronary artery disease (CAD) may be obtained with static single-scan stress perfusion cardiac computed tomography (SSPCT). Purpose To determine the diagnostic performance of static SSPCT for identifying hemodynamically significant CAD. Material and Methods This prospective study included 29 patients with suspected or known CAD who underwent static SSPCT, cardiovascular magnetic resonance myocardial perfusion imaging (CMR-MPI), and invasive coronary angiography (ICA). Read More

    Spectrum of Coronary Artery Aneurysms: From the Radiologic Pathology Archives.
    Radiographics 2018 Jan-Feb;38(1):11-36
    From the Department of Diagnostic Radiology and Nuclear Medicine (J.J., C.S.W., R.H., A.A.F.) and Department of Pathology (A.P.B.), University of Maryland School of Medicine, 22 S Greene St, Baltimore, MD 21201; Department of Radiology, University of California San Diego School of Medicine, San Diego, Calif (S.J.K.); Department of Radiology, Yale University School of Medicine, New Haven, Conn (J.L.K.); Department of Radiology, University of Pittsburgh Medical Center, Pittsburgh, Pa (J.W.S.); Department of Radiology, North Shore University Hospital, Manhasset, NY (A.B.S.); and American Institute for Radiologic Pathology, American College of Radiology, Silver Spring, Md (A.A.F.).
    Advances in medical diagnosis reveal that coronary artery aneurysms (CAAs) may develop in several clinical scenarios and manifest variable symptoms, imaging appearances, and outcomes. Aneurysms are pathologically classified into three groups: atherosclerotic, inflammatory, and noninflammatory. The last category is associated with congenital, inherited, and connective tissue disorders. Read More

    Diagnostic accuracy and prognostic value of simultaneous hybrid 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis.
    Eur Heart J Cardiovasc Imaging 2018 Jan 8. Epub 2018 Jan 8.
    University College London Institute for Cardiovascular Science and Barts Heart Centre, St. Bartholomew's Hospital, West Smithfield, EC1A 7BE, London, UK.
    Aims: Cardiac death is the leading cause of mortality in patients with sarcoidosis, yet cardiac involvement often remains undetected. Cardiovascular magnetic resonance imaging (CMR) and 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) have been used to diagnose cardiac sarcoidosis (CS) yet never simultaneously in a cohort. This study sought to assess the diagnostic and prognostic utility of simultaneous hybrid cardiac PET/MR. Read More

    Variables associated with lung congestion as assessed by chest ultrasound in diabetics undergoing hemodialysis.
    J Bras Nefrol 2017 Oct-Dec;39(4):406-412
    Universidade Federal do Ceará, Campus de Sobral, Faculdade de Medicina, Sobral - CE, Brazil.
    Introduction: Ultrasound is an emerging method for assessing lung congestion but is still seldom used. Lung congestion is an important risk of cardiac events and death in end-stage renal disease (ESRD) patients on hemodialysis (HD).

    Objective: We investigated possible variables associated with lung congestion among diabetics with ESRD on HD, using chest ultrasound to detect extracellular lung water. Read More

    An eight-year prospective controlled study about the safety and diagnostic value of cardiac and non-cardiac 1.5-T MRI in patients with a conventional pacemaker or a conventional implantable cardioverter defibrillator.
    Eur Radiol 2018 Jan 9. Epub 2018 Jan 9.
    Unit of Radiology, IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy.
    Objectives: To investigate safety and diagnostic value of 1.5-T MRI in carriers of conventional pacemaker (cPM) or conventional implantable defibrillator (cICD).

    Methods: We prospectively compared cPM/cICD-carriers undergoing MRI (study group, SG), excluding those device-dependent or implanted <6 weeks before enrolment or prior to 01/01/2000, with cPM/cICD-carriers undergoing chest x-ray, CT or follow-up (reference group, RG). Read More

    Fully automated segmentation of the left ventricle in cine cardiac MRI using neural network regression.
    J Magn Reson Imaging 2018 Jan 9. Epub 2018 Jan 9.
    Department of Biomedical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur, Malaysia.
    Background: Left ventricle (LV) structure and functions are the primary assessment performed in most clinical cardiac MRI protocols. Fully automated LV segmentation might improve the efficiency and reproducibility of clinical assessment.

    Purpose: To develop and validate a fully automated neural network regression-based algorithm for segmentation of the LV in cardiac MRI, with full coverage from apex to base across all cardiac phases, utilizing both short axis (SA) and long axis (LA) scans. Read More

    Intramyocardial dissecting hematoma: Two case reports and a meta-analysis of the literature.
    Echocardiography 2018 Jan 9. Epub 2018 Jan 9.
    Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, Israel.
    Until recently, diagnosis of intramyocardial dissecting hematoma (IDH) was performed during necropsy or at surgery. During the recent years, echocardiography has permitted clinical suspicion, which usually needed confirmation with magnetic resonance imaging (MRI). In this study, we tried to define clinical and imaging features of IDH and predictors of mortality. Read More

    Biodistribution and tolerance of intravenous iodine-131-labelled hypericin in healthy dogs.
    Vet Comp Oncol 2018 Jan 4. Epub 2018 Jan 4.
    Small Animal Department, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
    Hypericin (Hyp) is a necrosis-avid compound that can be efficiently labelled with radioiodine for both diagnostic and therapeutic purposes. Before 131 I-Hyp can be considered as a clinically useful drug in a combination therapy for canine cancer patients, evaluation of its toxicity is necessary. The aim of this study was to investigate the biodistribution and tolerance of a single dose administration of 131 I-Hyp. Read More

    Coronary Embolism Among ST-Segment-Elevation Myocardial Infarction Patients: Mechanisms and Management.
    Circ Cardiovasc Interv 2018 Jan;11(1):e005587
    From the Département de Cardiologie (B.P., N.B., S.P., C.H.M., P.A.M., C.S.S., Y.J., E.C.) and Epidémiologie et Evaluation Cliniques (N.A.), CHU Nancy, France.
    Background: Coronary artery embolism (CE) is recognized as an important nonatherosclerotic cause of ST-segment-elevation myocardial infarction. The objective was to describe clinical characteristics and long-term outcomes and to identify risks factors of CE in a large consecutive series of ST-segment-elevation myocardial infarction patients.

    Methods And Results: We studied 1232 consecutive patients who presented with de novo ST-segment-elevation myocardial infarction. Read More

    Increased Left Ventricular Filling Pressure and Arterial Occlusion in Stroke Related to Atrial Fibrillation.
    J Stroke Cerebrovasc Dis 2018 Jan 5. Epub 2018 Jan 5.
    Department of Neurology, Dongguk University Ilsan Hospital, Goyang, South Korea. Electronic address:
    Background: We investigated whether left ventricular filling pressure is associated with arterial occlusion in patients with ischemic stroke related to atrial fibrillation (AF).

    Methods: Ninety-nine patients with AF-related stroke were included. Left ventricular filling pressure was assessed by E (early mitral inflow velocity)/e' (early diastolic velocity of the mitral valve annulus velocity) ratio based on tissue Doppler echocardiography. Read More

    Extracorporeal membrane oxygenation combined with continuous renal replacement therapy in cutaneous burn and inhalation injury caused by hydrofluoric acid and nitric acid.
    Medicine (Baltimore) 2017 Dec;96(48):e8972
    Department of Critical Care Medicine, Suzhou Municipal Hospital Affiliated to Nanjing Medical University, Suzhou, China.
    Rationale: Hydrofluoric acid (HF) is a highly corrosive agent and can cause corrosive burns. HF can penetrate deeply into tissues through intact skin and the lipid barrier, leading to painful liquefactive necrosis, and inducing hypocalcemia and hypomagnesemia. In this study, we hypothesize that continuous renal replacement therapy (CRRT) may be beneficial in addressing hemodynamic instability in cases of HF poisoning. Read More

    EBV lymphoproliferative-associated disease and primary cardiac T-cell lymphoma in a STK4 deficient patient: A case report.
    Medicine (Baltimore) 2017 Dec;96(48):e8852
    Department of Pediatrics, Dr. von Hauner Children's Hospital, Ludwig Maximilians University, Munich, Germany.
    Rationale: Primary cardiac lymphoma (PLC) is an extremely uncommon malignancy. PCL is more common in secondary immunodeficient patients. In this report, we describe a unique case of PLC who had been diagnosed as a STK4 deficient patient. Read More

    Efficacy of the multidisciplinary tumor board conference in gynecologic oncology: A prospective study.
    Medicine (Baltimore) 2017 Dec;96(48):e8089
    Department of Obstetrics and Gynecology.
    Evidence has shown that multidisciplinary tumor board conferences (MTBCs) improve patient management for various cancer types. However, few retrospective studies have investigated MTBC efficacy for patients with gynecologic cancers. Here, we prospectively aimed to evaluate how MTBCs influence patient management in gynecologic oncology. Read More

    Follicle-Stimulating Hormone Levels and Subclinical Atherosclerosis in Older Postmenopausal Women.
    Am J Epidemiol 2018 Jan;187(1):16-26
    Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
    Recent studies of perimenopausal women suggest that follicle-stimulating hormone (FSH) levels may be associated with atherosclerosis, independent of estradiol. Whether FSH is related to atherosclerosis in older postmenopausal women, who have completed the menopausal transition, remains unknown. We assessed the relationship of serum FSH and estradiol levels with carotid artery intima-media thickness (IMT) among 587 postmenopausal participants in the Kuopio Ischemic Heart Disease Risk Factor Study (Kuopio, Finland). Read More

    Carotid Ultrasound for Assessment of Nonobstructive Carotid Atherosclerosis in Young Adults with Cryptogenic Stroke.
    J Stroke Cerebrovasc Dis 2018 Jan 5. Epub 2018 Jan 5.
    Department of Neurology, Toulouse University Hospital, Toulouse, France.
    Background: The role of nonobstructive (<50% stenosis) carotid atherosclerosis (NOCA) in young adults with ischemic stroke is not well understood. In the present study, we investigated the prevalence and the ultrasonic characteristics of NOCA in a consecutive series of young adults with cryptogenic stroke (CS).

    Methods: Patients aged 18-54, consecutively treated in a tertiary hospital for first-ever CS (defined as an ischemic stroke without ASCOD (A: atherosclerosis; S: small-vessel disease; C: cardiac pathology; O: other causes) grade 1 potential cause) in the carotid artery territory, were prospectively enrolled. Read More

    How common is isolated cardiac sarcoidosis? Extra-cardiac and cardiac findings on clinical examination and whole-body 18F-fluorodeoxyglucose positron emission tomography.
    Int J Cardiol 2018 Feb;253:189-193
    Division of Cardiology, Department of Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address:
    Background: Sarcoidosis is a systemic inflammatory disease which can involve nearly any organ. Clinically manifest cardiac involvement occurs in perhaps 5% of patients with sarcoidosis. The reported prevalence of isolated cardiac sarcoidosis (CS) varies widely with reported rates of 27-54%. Read More

    Quantitative inversion time prescription for myocardial late gadolinium enhancement using T1-mapping-based synthetic inversion recovery imaging: reducing subjectivity in the estimation of inversion time.
    Int J Cardiovasc Imaging 2018 Jan 5. Epub 2018 Jan 5.
    Division of Cardiovascular Imaging, Department of Radiology and Radiological Science, Medical University of South Carolina, 25 Courtenay Dr, MSC 226, Charleston, SC, 29425, USA.
    To develop a quantitative T1-mapping-based synthetic inversion recovery (IRsynth) approach to calculate the optimal inversion time (TI0) for late gadolinium enhancement (LGE) imaging. Prospectively enrolled patients (n = 130, 58 ± 16 years) underwent cardiac MRI on a 1.5T system including Look-Locker TI-scout (LL), modified LL IR (MOLLI)-based T1-mapping, and LGE acquisitions. Read More

    Warfarin anticoagulation in acute type A aortic dissection survivors (WATAS).
    Cardiovasc Diagn Ther 2017 Dec;7(6):559-571
    University Center for Vascular Medicine and Division of Angiology, Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
    Background: Early survivors of acute type A aortic dissection (AAAD) remain at risk for late death and late aortic events. However, the frequency and long-term effects of warfarin anticoagulation on long-term outcome in post-surgical AAAD survivors have not been elucidated.

    Methods: Two tertiary care centers performed a retrospective observational cohort study of warfarin anticoagulation in AAAD in 243 persons with early survival of surgical repair (WATAS). Read More

    The Key Roles of Negative Pressure Breathing and Exercise in the Development of Interstitial Pulmonary Edema in Professional Male SCUBA Divers.
    Sports Med Open 2018 Jan 3;4(1). Epub 2018 Jan 3.
    Biological Physics Group, University of Manchester, Manchester, UK.
    Background: Immersion pulmonary edema is potentially a catastrophic condition; however, the pathophysiological mechanisms are ill-defined. This study assessed the individual and combined effects of exertion and negative pressure breathing on the cardiovascular system during the development of pulmonary edema in SCUBA divers.

    Methods: Sixteen male professional SCUBA divers performed four SCUBA dives in a freshwater pool at 1 m depth while breathing air at either a positive or negative pressure both at rest or with exercise. Read More

    Lupus myocarditis receiving the rituximab therapy-a monocentric retrospective study.
    Clin Rheumatol 2018 Jan 3. Epub 2018 Jan 3.
    Section of Critical Care Medicine, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan.
    Despite high-dose corticosteroids alone or with immunosuppressive agents as the standard therapy in lupus myocarditis (LM), an immune complex-mediated critical setting, such management is still associated with resistant disease and even mortality. A retrospective study was performed for the refractory LM patients treated with rituximab (RTX), a very limited experience in English literatures. A retrospective review of the myocarditis manifestation was carried out in hospitalized Han Chinese patients with SLE from February 2007 to January 2017. Read More

    3D reconstruction of coronary arteries from 2D angiographic projections using non-uniform rational basis splines (NURBS) for accurate modelling of coronary stenoses.
    PLoS One 2018 3;13(1):e0190650. Epub 2018 Jan 3.
    Radcliffe Department of Medicine, Oxford Acute Vascular Imaging Centre, University of Oxford, Oxford, United Kingdom.
    Objective: Assessment of coronary stenosis severity is crucial in clinical practice. This study proposes a novel method to generate 3D models of stenotic coronary arteries, directly from 2D coronary images, and suitable for immediate assessment of the stenosis severity.

    Methods: From multiple 2D X-ray coronary arteriogram projections, 2D vessels were extracted. Read More

    Exercise Electrocardiogram Neither Predicts Nor Excludes Coronary Artery Disease in Women with Low to Intermediate Risk.
    J Womens Health (Larchmt) 2018 Jan 3. Epub 2018 Jan 3.
    1 Cardiac Imaging Division Alkmaar, Northwest Clinics , Alkmaar, The Netherlands .
    Aim: The value of exercise electrocardiogram (ExECG) in symptomatic female patients with low to intermediate risk for significant coronary artery disease (CAD) has been under debate for many years, and nondiagnostic or even erroneous test results are frequently encountered. Cardiac-CT may be more appropriate to exclude CAD in women. This study compares the results of ExECGs with those of cardiac-CTs, performed within a time frame of 1 month in an all-comers female chest pain population. Read More

    Multimodal Imaging for the Assessment of a Cardiac Mass - A Case of Primary Cardiac Sarcoma.
    J Radiol Case Rep 2017 Nov 30;11(11):11-19. Epub 2017 Nov 30.
    Institute of Radiology and Nuclear Medicine, Paracelsus Medical University, Nuremberg General Hospital, Germany.
    We present a case of an 85-year-old patient who underwent clinical work-up for chronic heart failure, acute coronary syndrome, and pulmonary embolism, until she was diagnosed with a cardiac mass that was histologically identified as sarcoma. The aim of this educational case report is to raise awareness of cardiac masses and to point out diagnostic hints towards a cardiac tumor on chest X-ray, coronary angiography, echocardiography, and chest CT. Moreover, the vital role of cardiac magnetic resonance for the diagnosis of a cardiac mass is highlighted. Read More

    Proteomic Profiling for Cardiovascular Biomarker Discovery in Orthostatic Hypotension.
    Hypertension 2018 Jan 2. Epub 2018 Jan 2.
    From the Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden (M.J., O.M., A.F.); Institute for Advanced Biomedical Technologies, Department of Neuroscience, Imaging and Clinical Sciences, "G.d'Annunzio" University, Chieti, Italy (F.R.); William Harvey Research Institute, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit at Barts, Queen Mary University of London, United Kingdom (N.A.); National Heart and Lung Institute, Imperial College, Hammersmith Hospital Campus, London, United Kingdom (R.S.); and Department of Cardiology, Skåne University Hospital, Malmö, Sweden (A.F.).
    Orthostatic hypotension (OH) has been linked with higher incidence of cardiovascular disease, but little is known about the mechanisms behind this association. We aimed to identify cardiovascular disease biomarkers associated with OH through a proteomic profiling approach. Seven hundred seventy-eight patients with unexplained syncope or orthostatic intolerance underwent head-up tilt test and supine blood samples. Read More

    Radiation dose management for pediatric cardiac computed tomography: a report from the Image Gently 'Have-A-Heart' campaign.
    Pediatr Radiol 2018 01 1;48(1):5-20. Epub 2018 Jan 1.
    Department of Radiology, Duke University Medical Center, Durham, NC, USA.
    Children with congenital or acquired heart disease can be exposed to relatively high lifetime cumulative doses of ionizing radiation from necessary medical imaging procedures including radiography, fluoroscopic procedures including diagnostic and interventional cardiac catheterizations, electrophysiology examinations, cardiac computed tomography (CT) studies, and nuclear cardiology examinations. Despite the clinical necessity of these imaging studies, the related ionizing radiation exposure could pose an increased lifetime attributable cancer risk. The Image Gently "Have-A-Heart" campaign is promoting the appropriate use of medical imaging studies in children with congenital or acquired heart disease while minimizing radiation exposure. Read More

    Magnetic resonance is a safe imaging technique in patients with prosthetic heart valves and coronary stents.
    Hellenic J Cardiol 2017 Dec 29. Epub 2017 Dec 29.
    1(st) Department of Cardiology, Aristotle University of Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
    The paper refers to the safety of MRI in patients with prosthetic heart valves or coronary stents. This is commonly regarded as a contraindication for MRI excluding patients from the diagnostic imaging information provided by one of the most important noninvasive imaging modalities. Based on available evidence to date, all patients with prosthetic heart valves or coronary stents can safely undergo MRI at 1. Read More

    Identification of type IV collagen exposure as a molecular imaging target for early detection of thoracic aortic dissection.
    Theranostics 2018 1;8(2):437-449. Epub 2018 Jan 1.
    Beijing Anzhen Hospital, Capital Medical University; Key Laboratory of Remodeling-Related Cardiovascular Diseases, Ministry of Education; Beijing collaborative innovative research center for cardiovascular diseases; Beijing Institute of Heart Lung and Blood Vessel Diseases, Beijing 100029 China.
    Thoracic aortic dissection (TAD) is an aggressive and life-threatening vascular disease and there is no effective means of early diagnosis of dissection. Type IV collagen (Col-IV) is a major component of the sub-endothelial basement membrane, which is initially exposed followed by endothelial injury as early-stage event of TAD. So, we want to build a noninvasive diagnostic method to detect early dissection by identifying the exposed Col-IV via MRI. Read More

    Prolonged Dexmedetomidine Infusion and Drug Withdrawal In Critically Ill Children.
    J Pediatr Pharmacol Ther 2017 Nov-Dec;22(6):453-460
    Department of Critical Care Medicine (ASH, WS, PCL, CRB), The Hospital for Sick Children, Toronto, Canada; Department of Pharmacy (WS), The Hospital for Sick Children, Toronto, Canada; Department of Diagnostic Imaging and Neuroscience & Mental Health Program (CMU), The Hospital for Sick Children Research Institute, Toronto, Canada; Department of Clinical research services (DS), The Hospital for Sick Children, Toronto, Canada; and University of Toronto (DRB, PCL, WS), Toronto, Ontario, Canada.
    Objective: To characterise the incidence, symptoms and risk factors for withdrawal associated with prolonged dexmedetomidine infusion in paediatric critically ill patients.

    Methods: Retrospective chart review in the paediatric intensive care unit and the cardiac critical care unit of a single tertiary children's hospital. Patients up to 18 years old, who received dexmedetomidine for longer than 48 hours were included. Read More

    Diaphragm Muscle Dysfunction in Patients with Heart Failure.
    J Card Fail 2017 Dec 28. Epub 2017 Dec 28.
    Division of Cardiovascular Medicine, Department of Molecular Medicine and Therapeutics, Faculty of Medicine, Tottori University, Yonago, Japan.
    Background: Inspiratory muscle weakness is associated with the development of exercise intolerance in patients with heart failure (HF). Ultrasound assessment of the diaphragm is used to evaluate respiratory muscle function, but its application in patients with HF remains undefined. We examined the relationship of diaphragm function as assessed by ultrasonography with inspiratory muscle strength and exercise tolerance in HF. Read More

    Left Ventricular Torsion Shear Angle Volume Approach for Noninvasive Evaluation of Diastolic Dysfunction in Preserved Ejection Fraction.
    J Am Heart Assoc 2017 Dec 29;7(1). Epub 2017 Dec 29.
    Department of Medicine, University of Alabama at Birmingham, AL
    Background: Accurate noninvasive diagnostic tools for evaluating left ventricular (LV) diastolic dysfunction (LVDD) are limited in preserved LV ejection fraction. We previously proposed the relationship of normalized rate of change in LV torsion shear angle (φ') to corresponding rate of change in LV volume (V') during early diastole (represented as -dφ'/dV') as a measure of LV diastolic function. We prospectively evaluated diagnostic accuracy of -dφ'/dV' in respect to invasive LV parameters. Read More

    Isolated coarctation of the aorta in the fetus: A diagnostic challenge.
    Echocardiography 2017 Dec;34(12):1768-1775
    Baylor College of Medicine, Texas Children's Hospital, Houston, TX, USA.
    Isolated coarctation of the aorta (CoA) is estimated by the Centers for Disease Control and Prevention to account for 4%-6% of all congenital heart disease (CHD) in the United States, with a reported prevalence of ~4 per 10 000 live births. Prenatal recognition of coarctation is important as it may improve neonatal survival and reduce morbidity. However, despite advances in imaging and the trend toward detailed aortic arch assessment as part of a comprehensive fetal echocardiogram, isolated CoA may still elude prenatal detection, with potentially lethal consequences if the diagnosis is not suspected and the patent ductus arteriosus (PDA) closes spontaneously in postnatal life. Read More

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