48,497 results match your criteria Ulcerative Colitis


[Network pharmacological analysis and preliminary validation of mechanisms of Baitouweng Decoction in treatment of ulcerative colitis].

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(8):1808-1815

Jiangsu Province Hospital of Chinese Medicine Nanjing 210029, China.

The aim of this paper was to explore the pharmacological mechanism of Baitouweng Decoction in the treatment of ulcerative colitis(UC) by network pharmacology and to preliminarily verify the related targets by animal experiments. Cytoscape software was used to construct "ingredient-target-disease" network through TCMSP, GeneCards and Uniprot databases. The protein interaction network was constructed using STRING database, and the core targets were speculated. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191112.406DOI Listing

[Bioinformatic analysis of differentially expressed genes and Chinese medicine prediction for ulcerative colitis].

Zhongguo Zhong Yao Za Zhi 2020 Apr;45(7):1684-1690

School of Basic Medical Science of Guangzhou University of Chinese Medicine Guangzhou 510006, China.

The aim of this paper was to analyze the microarray data between ulcerative colitis(UC) patients and healthy people by bioinformatics technology, screen the differentially expressed genes of UC, and predict the potential Chinese medicines for UC. The GSE36807 gene expression profile was downloaded from the gene expression database(GEO) and the differentially expressed(both up-regulated and down-regulated) genes(DEGs) were analyzed by using R language software. The core genes in the DEGs were obtained by using String database, Cytoscape software and its plug-in analysis, and the gene ontology(GO) and Kyoto encyclopedia of genes and genomes(KEGG) were used to analyze the core genes. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20191030.401DOI Listing

Structural Changes in the Nervous Fibers of the Colon Mucosa in Experimental Acute Colitis.

Bull Exp Biol Med 2020 Jun 2. Epub 2020 Jun 2.

Research Institute of Human Morphology, Moscow, Russia.

Morphological, morphometric, and ultrastructural analysis of the nerve fibers in the colon mucosa was performed in C57BL/6 mice at various terms of development of acute colitis induced by dextran sodium sulphate. The nerve fibers were labeled with antibodies to pan-neuronal marker βIII-tubulin. The progression of inflammatory and ulcerative processes in the mucosa on days 3-5 was associated with hyperplasia and hypertrophy of nerve fibers that peaked on day 7 after colitis induction. Read More

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http://dx.doi.org/10.1007/s10517-020-04834-5DOI Listing

Total proctocolectomy with end ileostomy for acute onset of ulcerative colitis during chemoradiotherapy for lung adenocarcinoma (successfully treated by surgery): a case report.

Surg Case Rep 2020 Jun 1;6(1):121. Epub 2020 Jun 1.

Department of General Surgery, Toyohashi Municipal Hospital, 50 Hachiken-nishi, Aotake-cho, Toyohashi, Aichi, 441-8570, Japan.

Background: Ulcerative colitis (UC) developing during chemotherapy is very rare. Here, we describe a case of acute onset during chemoradiotherapy for lung adenocarcinoma, requiring a total proctocolectomy.

Case Presentation: A 52-year-old man was admitted to the hospital for chemoradiotherapy of lung cancer. Read More

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http://dx.doi.org/10.1186/s40792-020-00886-xDOI Listing

The management of the hospitalized ulcerative colitis patient: the medical-surgical conundrum.

Curr Opin Gastroenterol 2020 Jun 1. Epub 2020 Jun 1.

Department of Colon and Rectal Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Purpose Of Review: In this review article, we address emerging evidence for the medical and surgical treatment of the hospitalized patient with ulcerative colitis.

Recent Findings: Ulcerative colitis is a chronic inflammatory disease involving the colon and rectum. About one-fifth of patients will be hospitalized from ulcerative colitis, and about 20-30%, experiencing an acute flare will undergo colectomy. Read More

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http://dx.doi.org/10.1097/MOG.0000000000000637DOI Listing

Impacts of foodborne inorganic nanoparticles on the gut microbiota-immune axis: potential consequences for host health.

Part Fibre Toxicol 2020 Jun 1;17(1):19. Epub 2020 Jun 1.

INRAE Toxalim UMR 1331 (Research Center in Food Toxicology), Team Endocrinology and Toxicology of the Intestinal Barrier, INRAE, Toulouse University, ENVT, INP-Purpan, UPS, 180 Chemin de Tournefeuille, 31027, Toulouse cedex 3, France.

Background: In food toxicology, there is growing interest in studying the impacts of foodborne nanoparticles (NPs, originating from food additives, food supplements or food packaging) on the intestinal microbiome due to the important and complex physiological roles of these microbial communities in host health. Biocidal activities, as described over recent years for most inorganic and metal NPs, could favour chronic changes in the composition and/or metabolic activities of commensal bacteria (namely, intestinal dysbiosis) with consequences on immune functions. Reciprocally, direct interactions of NPs with the immune system (e. Read More

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http://dx.doi.org/10.1186/s12989-020-00349-zDOI Listing

[Different viral doses of cytomegalovirus infection in the left and right colons].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):583-587

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To compare the differences in the detection rates of cytomegalovirus (CMV) infection between the left and right colons for guiding endoscopic biopsy-sites. The cases of colonic CMV infection confirmed by histology at the Peking Union Medical College Hospital from July 2015 to July 2018 were collected and analyzed. Splenic curvature was used as the dividing point between the left and right colons. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190924-00523DOI Listing

Matching between Donors and Ulcerative Colitis Patients Is Important for Long-Term Maintenance after Fecal Microbiota Transplantation.

J Clin Med 2020 May 31;9(6). Epub 2020 May 31.

Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.

We previously demonstrated that fresh fecal microbiota transplantation (FMT) following triple antibiotic therapy (amoxicillin, fosfomycin, metronidazole (AFM); A-FMT) resulted in effective colonization of Bacteroidetes species, leading to short-term clinical response in ulcerative colitis (UC). Its long-term efficacy and criteria for donor selection are unknown. Here, we analyzed the long-term efficacy of A-FMT compared to AFM monotherapy (mono-AFM). Read More

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http://dx.doi.org/10.3390/jcm9061650DOI Listing

Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease.

Int J Mol Sci 2020 May 31;21(11). Epub 2020 May 31.

Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO 65212, USA.

Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in vivo experiments demonstrate that phytochemicals and natural macromolecules from plants and animals reduce IBD-related complications with encouraging results. Read More

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http://dx.doi.org/10.3390/ijms21113956DOI Listing

Extracts and Marine Algae Polysaccharides in Therapy and Prevention of Inflammatory Diseases of the Intestine.

Mar Drugs 2020 May 31;18(6). Epub 2020 May 31.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, FEB RAS, Vladivostok 690022, Russia.

Inflammatory bowel disease (IBD) is a serious public health problem worldwide. Current therapeutic strategies that use anti-inflammatory drugs, immunosuppressants, and biological treatments are often ineffective and have adverse health effects. In this regard, the use of natural compounds aimed at key pathogenic therapeutic targets in IBD attracts universal attention. Read More

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http://dx.doi.org/10.3390/md18060289DOI Listing

Evodiamine has therapeutic efficacy in ulcerative colitis by increasing Lactobacillus acidophilus levels and acetate production.

Pharmacol Res 2020 May 30:104978. Epub 2020 May 30.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China. Electronic address:

Emerging evidence implicates gut microbiota have an important role in ulcerative colitis (UC). Previous study indicated that Evodiamine (EVO) can alleviate colitis through downregulating inflammatory pathways. However, specific relationship between EVO-treated colitis relief and regulation of gut microbiota is still unclear. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104978DOI Listing

Growth failure is rare in a contemporary cohort of paediatric inflammatory bowel disease patients.

Acta Paediatr 2020 Jun 2. Epub 2020 Jun 2.

Department of Paediatric Gastroenterology, Southampton Children's Hospital, Southampton, UK.

Aim: We assessed growth in a paediatric inflammatory bowel disease (PIBD) cohort.

Methods: PIBD patients were eligible if they were diagnosed at Southampton Children's Hospital from 2011-2018. Weight and height standard-deviation-scores (SDS) were retrieved. Read More

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http://dx.doi.org/10.1111/apa.15383DOI Listing

Faecal Microbiota Transplantation in Inflammatory Bowel Disease: current concepts and future challenges.

Curr Drug Targets 2020 Jun 2. Epub 2020 Jun 2.

Clinic of Gastroenterology, Tsaritsa Yoanna University Hospital, Medical University of Sofia, Sofia. Bulgaria.

Dysbiosis has been repeatedly observed in inflammatory bowel disease (IBD) and is now recognized as an essential factor in the gut inflammatory process. IBD is a significant burden to health-care systems, mainly due to treatment-related costs. Available treatments have several limitations: up to 30% of patients are primary non-responders, and between 10 and 20% lose response per year, requiring a dose-escalation or a switch to another biologic. Read More

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http://dx.doi.org/10.2174/1389450121666200602125507DOI Listing

Optimization of a High-Throughput Cell-Based Screening Strategy to Identify Small-Molecule Inhibitors of IL-23 Signaling.

SLAS Discov 2020 Jun 2:2472555220923362. Epub 2020 Jun 2.

Lead Discovery & Profiling, Janssen Research & Development, Spring House, PA, USA.

Interleukin-23 (IL-23) is a key cytokine implicated in the pathogenesis of autoimmune disorders, including psoriasis and ulcerative colitis. Although targeted IL-23 antibody therapeutics are used clinically, there are no small-molecule therapeutics that selectively inhibit IL-23 signaling. To address this gap, we developed a high-throughput screening strategy employing an IL-23-responsive cell-based luciferase reporter gene assay as the primary screen, with cellular cytotoxicity and off-target counter screening assays to identify IL-23 pathway-specific inhibitors. Read More

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http://dx.doi.org/10.1177/2472555220923362DOI Listing

An Indian national survey of therapeutic drug monitoring with anti-tumor necrosis (TNF) medications in inflammatory bowel disease.

Indian J Gastroenterol 2020 Jun 1. Epub 2020 Jun 1.

The Pennine Acute Hospitals NHS Trust, Manchester Academic Health Sciences, University of Manchester, Manchester, UK.

Background: Evidence supports therapeutic drug monitoring (TDM) in improving efficacy and cost-effectiveness of anti-TNF therapy in inflammatory bowel disease (IBD). Data on perceptions and barriers to TDM use are limited and no data are available from India. Our objective was to assess clinicians' attitudes and barriers to TDM use in IBD. Read More

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http://dx.doi.org/10.1007/s12664-020-01047-6DOI Listing

Myositis as an Initial Presentation of Ulcerative Colitis before Gastrointestinal Symptoms.

Pediatr Gastroenterol Hepatol Nutr 2020 May 8;23(3):297-303. Epub 2020 May 8.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

The musculoskeletal system can be involved as an extra-intestinal manifestation of inflammatory bowel disease. Among these, myositis in ulcerative colitis (UC) is very rare. A 14-year-old girl was admitted due to severe shoulder tenderness. Read More

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http://dx.doi.org/10.5223/pghn.2020.23.3.297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231739PMC

Inflammatory Bowel Disease in Children: Experience and Constraints in a Resource-limited Setting.

Cureus 2020 Apr 27;12(4):e7848. Epub 2020 Apr 27.

Pediatrics/Pediatric Gastroenterology, Hepatology and Nutrition Division, University of Calabar/University of Calabar Teaching Hospital, Calabar, NGA.

Introduction: Inflammatory bowel disease (IBD), though well described in the Caucasian population, is rarely encountered in the black African children. The aim of this study was to increase the awareness of this emerging condition in African children and highlight the constraints of management in a resource-limited setting like Nigeria.

Methods: This study included an audit of children with IBD who were seen between January 2015 and February 2020 at the Lagos University Teaching Hospital (LUTH). Read More

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http://dx.doi.org/10.7759/cureus.7848DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253077PMC

Leucine-rich alpha-2 glycoprotein 1, high mobility group box 1, matrix metalloproteinase 3 and annexin A1 as biomarkers of ulcerative colitis endoscopic and histological activity.

Eur J Gastroenterol Hepatol 2020 May 29. Epub 2020 May 29.

Department of Basic Medical Sciences, Laboratory of Biology, Medical School, National and Kapodistrian University of Athens.

Objective: The LRG, HMGB1, MMP3 and ANXA1 proteins have been implicated in different inflammatory pathways in ulcerative colitis (UC), but their role as specific biomarkers of both endoscopic and histological activity has yet to be elucidated. In the present study, we aimed to evaluate the LRG1, HMGB1, MMP3 and ANXA1 as potential serum biomarkers for UC endoscopic and histological activity.

Methods: This cross-sectional study included UC patients under 5-ASA, and healthy controls (HC) undergoing colonoscopy. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001783DOI Listing

Patients With Inflammatory Bowel Diseases Are at Higher Risk for Meningitis.

J Clin Gastroenterol 2020 May 29. Epub 2020 May 29.

Multidisciplinary Center for Inflammatory Bowel Diseases.

Background: The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients.

Goals: We aimed to determine the incidence of and risk factors for meningitis in IBD patients.

Study: We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated Claims Database from January 2001 to June 2016. Read More

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http://dx.doi.org/10.1097/MCG.0000000000001365DOI Listing

Gaps Exist in the Comprehensive Care of Children with Inflammatory Bowel Diseases.

J Pediatr 2020 May 29. Epub 2020 May 29.

Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA.

Objectives: To describe patterns of primary and specialty care delivery in pediatric patients with inflammatory bowel diseases (IBD), delineate which members of the healthcare team provided services, and identify gaps in care.

Study Design: Cross-sectional survey of parents of children (2-17 years) with IBD and adolescents with IBD (13-17 years) at a free-standing, quaternary children's hospital regarding healthcare receipt.

Results: There were 161 parents and 84 adolescents who responded to the survey (75% and 60% response, respectively). Read More

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http://dx.doi.org/10.1016/j.jpeds.2020.04.002DOI Listing

Efficacy of various endoscopic modalities in detecting dysplasia in ulcerative colitis: A systematic review and network meta-analysis.

World J Gastrointest Endosc 2020 May;12(5):159-171

Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, The University of Chicago Medicine, Chicago, IL 60637, United States.

Background: Longstanding ulcerative colitis (UC) is associated with an increased risk of colonic neoplasia. Various endoscopic modalities, such as chromoendoscopy (CE), narrow band imaging (NBI) and random biopsy have been introduced for surveillance, however, there exists a paucity of direct comparisons between them. We aimed to conduct a network meta-analysis of randomized controlled trials (RCTs) performed for surveillance of neoplasia in UC. Read More

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http://dx.doi.org/10.4253/wjge.v12.i5.159DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243576PMC

Assessment of clinical activity and severity using serum ANCA and ASCA antibodies in patients with ulcerative colitis.

Allergy Asthma Clin Immunol 2020 20;16:37. Epub 2020 May 20.

2Department of Gastroenterology, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi 300001 China.

Background: Ulcerative colitis (UC) is a chronic, non-specific inflammatory bowel disease (IBD) with unknown etiology. The lack of specific clinical manifestations, standard diagnostic criteria, objective and accurate indicators to the severity of the disease and the efficacy of the treatment, often results in difficulties in diagnosis and timely treatment of UC. Therefore, there is a need to develop a clinically suitable serum biomarker assay with high specificity and sensitivity. Read More

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http://dx.doi.org/10.1186/s13223-020-00433-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7238601PMC

[Effects of 6-Shogaol on Notch signaling pathway in colonic epithelial cells of ulcerative colitis mice].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Jan;36(1):90-93

Department of Oncology Tangdu Hospital, Air Force Military Medical University, Xian 710038, China.

Objective: To observe the regulatory effect of 6-Shogaol on Notch signal pathway in colonic epithelial cells of mice with ulcerative colitis.

Methods: Forty Kunming mice were randomly divided into normal group (n=10) and model group (n=30). The model of ulcerative colitis was induced by free drinking of 2% dextran sulfate sodium salt(DSS). Read More

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http://dx.doi.org/10.12047/j.cjap.5889.2020.020DOI Listing
January 2020

Microbiota changes induced by microencapsulated sodium butyrate in patients with inflammatory bowel disease.

Neurogastroenterol Motil 2020 May 31:e13914. Epub 2020 May 31.

Department of Surgery, Oncology and Gastroenterology (DISCOG), University Hospital of Padua, Padua, Italy.

Background: Butyrate has shown anti-inflammatory and regenerative properties, providing symptomatic relief when orally supplemented in patients suffering from various colonic diseases. We investigated the effect of a colonic-delivery formulation of butyrate on the fecal microbiota of patients with inflammatory bowel diseases (IBDs).

Methods: In this double-blind, placebo-controlled, pilot study, 49 IBD patients (n = 19 Crohn's disease, CD and n = 30 ulcerative colitis, UC) were randomized to oral administration of microencapsulated-sodium-butyrate (BLM) or placebo for 2 months, in addition to conventional therapy. Read More

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http://dx.doi.org/10.1111/nmo.13914DOI Listing

An assessment of dietary intake, food avoidance and food beliefs in patients with ulcerative colitis of different disease status.

Intest Res 2020 Jun 2. Epub 2020 Jun 2.

GUT Research Group, Faculty of Medicine, National University of Malaysia, Kuala Lumpur, Malaysia.

Background/aims: Ulcerative colitis (UC) is a chronic, relapsing and remitting inflammation of the gastrointestinal tract. Little is known about the link between dietary intake, food avoidance, and beliefs among UC patients of different disease severity. Therefore, this study aimed to assess the dietary intake, food avoidance, and beliefs among active and inactive UC patients. Read More

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http://dx.doi.org/10.5217/ir.2019.00042DOI Listing

Patterns of endoscopy during COVID-19 pandemic: a global survey of interventional inflammatory bowel disease practice.

Intest Res 2020 Jun 2. Epub 2020 Jun 2.

Center for Inflammatory Bowel Disease, Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, USA.

Background/aims: Performance of diagnostic or therapeutic endoscopic procedures in inflammatory bowel disease (IBD) patients can be challenging during a viral pandemic; the main concerns being the safety and protection of patients and health care providers (HCP). The aim of this study is to identify endoscopic practice patterns and outcomes of IBD and coronavirus disease 19 (COVID-19) with a worldwide survey of HCP.

Methods: The 20-item survey questionnaire was sent to physician members of the American Society for Gastrointestinal Endoscopy Special Interest Group in Interventional IBD, Chinese IBD Society Endoscopy Interest Group, and the China Crohn's and Colitis Foundation. Read More

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http://dx.doi.org/10.5217/ir.2020.00037DOI Listing

Inflammatory bowel disease and risk of small bowel cancer: a binational population-based cohort study from Denmark and Sweden.

Gut 2020 May 30. Epub 2020 May 30.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Objective: Crohn's disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD).

Design: In a binational, population-based cohort study from Sweden and Denmark of patients with IBD during 1969-2017 and matched reference individuals from the general population, we evaluated the risk of incident SBC and death from SBC. Read More

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http://dx.doi.org/10.1136/gutjnl-2020-320945DOI Listing

IL23 promotes antimicrobial pathways in human macrophages which are reduced with the IBD-protective IL23R R381Q variant.

Cell Mol Gastroenterol Hepatol 2020 May 28. Epub 2020 May 28.

Department of Internal Medicine, Section of Digestive Diseases, Yale University, New Haven, CT 06510. Electronic address:

Objective: IL23 is a major contributor to inflammatory bowel disease (IBD) pathogenesis and is being pursued as a therapeutic target, both through targeting IL23 alone or in combination with IL12. Unexpected trial outcomes highlight the importance of understanding the cell types through which IL23 regulates immune responses, and how IL23 and IL12 compare in these responses. Macrophages are key players in IBD, and IL23 was recently found to promote inflammatory outcomes in human macrophages. Read More

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http://dx.doi.org/10.1016/j.jcmgh.2020.05.007DOI Listing

Ex vivo mimicking of inflammation in organoids derived from patients with ulcerative colitis.

Gastroenterology 2020 May 28. Epub 2020 May 28.

Department of Chronic Diseases, Metabolism and Ageing (CHROMETA), Translational Research Center for Gastrointestinal Disorders (TARGID), KU Leuven, Leuven, Belgium; Department of Gastroenterology and Hepatology, University Hospitals Leuven, KU Leuven, Leuven, Belgium. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2020.05.064DOI Listing

Ileorectal Anastomosis versus Ileal Pouch-Anal Anastomosis for the Surgical Treatment of Ulcerative Colitis: A Markov Decision Analysis.

Dis Colon Rectum 2020 May 25. Epub 2020 May 25.

Background: Ileorectal anastomosis in patients with ulcerative colitis results in decreased postoperative morbidity and better functional outcome but leads to increased risk for rectal cancer compared to ileal pouch-anal anastomosis.

Objective: To compare ileorectal anastomosis with ileal pouch-anal anastomosis in ulcerative colitis, using a decision model.

Design: A Markov simulation model was designed to simulate clinical events of ileorectal anastomosis and ileal pouch-anal anastomosis over a time horizon of 40 years with time cycles of 1 year. Read More

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http://dx.doi.org/10.1097/DCR.0000000000001686DOI Listing

Paeoniflorin ameliorates ulcerative colitis by modulating the dendritic cell-mediated T17/T balance.

Inflammopharmacology 2020 May 29. Epub 2020 May 29.

Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.

Immunological tolerance is critical for maintaining gut homeostasis. An imbalance between interleukin-17 (IL-17)-producing T helper 17 (T17) cells and regulatory T cells (T cells) is involved in ulcerative colitis (UC) pathogenesis. Dendritic cells (DCs) are able to induce T cell differentiation. Read More

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http://dx.doi.org/10.1007/s10787-020-00722-6DOI Listing

Ileal pouch-anal anastomosis for ulcerative colitis: long-term outcomes and trends over time in a low-volume institution.

Ir J Med Sci 2020 May 29. Epub 2020 May 29.

Mater Misericordiae University Hospital, 46-47 Eccles Street, Dublin 7, Ireland.

Background: Ileal pouch-anal anastomosis (IPAA) can restore bowel continuity for patients with ulcerative colitis (UC) who have needed total colectomy with end ileostomy. Internationally, this surgery is recommended for centralisation focussing reflection on Irish outcomes.

Methods: Retrospective study examining patient outcomes after IPAA in our institution over a 15-year period using data from inflammatory bowel disease database, HIPE codes and clinical charts review between January 2002 and January 2018. Read More

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http://dx.doi.org/10.1007/s11845-020-02262-yDOI Listing

Effect of ulcerative colitis duration on the usefulness of immunochemical fecal occult blood test result as a disease activity biomarker.

Int J Colorectal Dis 2020 May 29. Epub 2020 May 29.

First Department of Medicine, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka, 431-3192, Japan.

Purpose: The effects of ulcerative colitis (UC) duration on biomarker accuracy are unknown. We investigated the effects of UC duration on the predictive accuracy of biomarkers including immunochemical fecal occult blood test (FOBT, also known as FIT), prostaglandin E-major urinary metabolite (PGE-MUM), and C-reactive protein (CRP).

Methods: We divided 133 samples into groups based on disease duration. Read More

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http://dx.doi.org/10.1007/s00384-020-03636-5DOI Listing

Laparoscopic derotation of a twisted pouch and redo ileal pouch-anal anastomosis: a video vignette.

Colorectal Dis 2020 May 29. Epub 2020 May 29.

Humanitas Clinical and Research Center IRCCS, Division of Colon and Rectal Surgery, Via Manzoni 56, 20089, Rozzano (Milano), Italy.

Proctocolectomy with ileal pouch-anal anastomosis (IPAA) is the standard restorative procedure in patients with ulcerative colitis (UC). IPAA provides good quality of life in the majority of patients. However, restorative proctocolectomy (RP) might be associated with pouch-related complications which could impair function and possibly require further surgical revision. Read More

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http://dx.doi.org/10.1111/codi.15166DOI Listing

Association of serum interleukin-6 and soluble interleukin-2-receptor levels with disease activity status in patients with inflammatory bowel disease: A prospective observational study.

PLoS One 2020 29;15(5):e0233811. Epub 2020 May 29.

Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Goettingen, Goettingen, Germany.

Crohn's disease (CD) and ulcerative colitis (UC) are characterized by overexpression of proinflammatory cytokines. We determined the association of serum levels of interleukin (IL)-6, soluble-IL-2-receptor (sIL-2R) and CRP as well as of faecal calprotectin (FC) values with disease activity in CD and UC patients. This prospective study included 145 CD and 84 UC patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233811PLOS

Retinoic Acid Is Elevated in the Mucosa of Patients With Active Ulcerative Colitis and Displays a Proinflammatory Role by Augmenting IL-17 and IFNγ Production.

Inflamm Bowel Dis 2020 May 29. Epub 2020 May 29.

Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.

Background: All-trans retinoic acid (RA) plays a crucial role in promoting Foxp3+ Treg generation while reciprocally inhibiting Th1/Th17 generation. Our previous research highlighted that in the face of inflammatory conditions, RA plays a contrary role where it aggravates intestinal inflammation by promoting interferon (IFN) γ and interleukin (IL)-17 differentiation in vitro.

Methods: In this study we translated our in vitro results into a clinical setting where we estimated mucosal and serum RA levels along with the immunophenotypic profile (IL-17, IFNγ, Foxp3, IL-10) in adaptive (CD4, CD8) and innate-like T cells (mucosal associated invariant T cells and γδ T cells) in patients with ulcerative colitis in remission or with active inflammation. Read More

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http://dx.doi.org/10.1093/ibd/izaa121DOI Listing

Trends of 5-Aminosalicylate Medication Use in Patients With Crohn Disease.

Inflamm Bowel Dis 2020 May 29. Epub 2020 May 29.

Department of Internal Medicine, Division of Gastroenterology and Hepatology, Michigan Medicine, Ann Arbor, Michigan, USA.

Background: 5-aminosalicylate (5-ASA) medications have a long history of use for the treatment of inflammatory bowel disease and continue to be widely prescribed today. The effectiveness of 5-ASAs in ulcerative colitis is clear; however, studies have shown little benefit for induction or maintenance treatment of Crohn disease (CD). We aimed to quantify usage and examine trends in 5-ASA prescription rates in patients with CD. Read More

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http://dx.doi.org/10.1093/ibd/izaa127DOI Listing

Identification and diagnosis of Crohn disease and ulcerative colitis in children.

J Paediatr Child Health 2020 May 29. Epub 2020 May 29.

Department of Gastroenterology, Sydney Children's Hospital, Sydney, New South Wales, Australia.

Crohn disease and ulcerative colitis are the two main types of inflammatory bowel disease. High rates of these conditions are seen in Australasian children - furthermore, increasing rates have been evident in recent years. Children can present with typical symptoms of abdominal pain, diarrhoea, haematochezia and/or weight loss. Read More

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http://dx.doi.org/10.1111/jpc.14925DOI Listing

Alpha-Linolenic Acid Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice.

Inflammation 2020 May 29. Epub 2020 May 29.

College of Veterinary Medicine and Veterinary Medical Research Institute, Jeju National University, Jeju, 63243, Republic of Korea.

Ulcerative colitis (UC) is a type of inflammatory bowel disease characterized by inflammation of the large intestine, rectal bleeding, and abdominal pain. It can be alleviated by certain bioactive compounds, including α-linolenic acid (ALA), which is a bioactive component in fermented black radish (Raphanus sativus L. var. Read More

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http://dx.doi.org/10.1007/s10753-020-01260-7DOI Listing

Decitabine attenuates dextran sodium sulfate‑induced ulcerative colitis through regulation of immune regulatory cells and intestinal barrier.

Int J Mol Med 2020 May 18. Epub 2020 May 18.

Department of Surgery, Minhang Hospital, Fudan University, Shanghai 201199, P.R. China.

To investigate the effect of decitabine on the regulation of intestinal barrier function in mice with inflammatory bowel disease, an experimental model of colitis was established via drinking water with dextran sulfate sodium (DSS). Hematoxylin and eosin staining was used to observe the pathological changes of the colon. Cytokine production was measured by an ELISA assay. Read More

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http://dx.doi.org/10.3892/ijmm.2020.4605DOI Listing

Dietary Zinc Intake and Inflammatory Bowel Disease in the French NutriNet-Santé Cohort.

Am J Gastroenterol 2020 May 27. Epub 2020 May 27.

Equipe de Recherche en épidémiologie nutritionnelle (EREN), Université Paris 13, Inserm U1153, Inra U1125, Cnam, CRESS, Bobigny, France.

Introduction: This study aimed to assess the association between incident Crohn's disease (CD) or incident ulcerative colitis (UC) and dietary zinc intake.

Methods: NutriNet-Santé cohort's participants who completed at least three 24-hour dietary records were included and incident CD or UC cases were identified. Multivariable Poisson models were performed to assess associations between tertiles of zinc intake and CD or UC. Read More

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http://dx.doi.org/10.14309/ajg.0000000000000688DOI Listing

Genetics and epigenetics of ibd.

Authors:
Vito Annese

Pharmacol Res 2020 May 25:104892. Epub 2020 May 25.

Head of Gastroenterology and Medical Director, Valiant Clinic, Dubai, United Arab Emirates; CBP American Hospital, Dubai, United Arab Emirates; Aggregate Professor United Arabian Emirates University, College of Medicine & Health Science, Al Ain, United Arab Emirates. Electronic address:

Inflammatory bowel diseases (IBD) are chronic intermittent inflammatory disorders of the gastrointestinal tract of unknown etiology but a clear genetic predisposition. Prompted by the first investigations on IBD families and twins, the genetic and epigenetic studies have produced an unprecedented amount of information in comparison with other immune-mediated or complex diseases. New inflammatory pathways and possible mechanisms of action have been disclosed, potentially leading to new-targeted therapy. Read More

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http://dx.doi.org/10.1016/j.phrs.2020.104892DOI Listing

Candidate Polymorphisms and Susceptibility to Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Gene 2020 May 25:144814. Epub 2020 May 25.

Department of Gastroenterology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310016, P.R. China. Electronic address:

Aims: The goal of our study is to investigate the contribution of the 13 single-nucleotide polymorphisms to inflammatory bowel disease (IBD), including Crohn's disease (CD) and Ulcerative colitis (UC).

Methods: A total of 44 articles were retrieved from bibliographic databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Through a comprehensive filtering procedure, 13 single-nucleotide polymorphisms were collected in the meta-analysis, which was done by Review Manager 5. Read More

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http://dx.doi.org/10.1016/j.gene.2020.144814DOI Listing

Treatment Pathways Leading to Biologic Therapies for Ulcerative Colitis and Crohn's Disease in the United States.

Clin Transl Gastroenterol 2020 Feb;11(2):e00128

Celgene Corporation, Summit, New Jersey, USA.

Objectives: Biologic therapies have been available for inflammatory bowel disease for >20 years, but patient outcomes have not changed appreciably over this time period. To better understand medication utilization for this disease, we evaluated a novel technique for visualizing treatment pathways, including initial treatment, switching, and combination therapies.

Methods: This retrospective, observational study used administrative claims data from the Truven Health MarketScan Commercial and Medicare Database. Read More

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http://dx.doi.org/10.14309/ctg.0000000000000128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145024PMC
February 2020

Productivity Loss Among Parents of Children with Inflammatory Bowel Diseases in Relation to Disease Activity and Patient's Quality of Life.

J Pediatr Gastroenterol Nutr 2020 May 26. Epub 2020 May 26.

Polish Association Supporting People with Inflammatory Bowel Disease "J-elita", Warsaw, Poland.

Objectives: To assess the productivity losses among the parents of children with inflammatory bowel diseases (IBDs) in Poland and their relationship with disease activity and the patient's quality of life.

Methods: A questionnaire-based self-reported Internet survey was conducted among the parents of patients (0-17 years old) with a diagnosis of ulcerative colitis (UC) or Crohn's disease (CD). Data on indirect and direct costs, general patient characteristics, disease activity, pharmacological treatment, and children's quality of life measured with the Pediatric Quality of Life Inventory (PedsQL) were collected. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002801DOI Listing

Systematic Review: Psychosocial Correlates of Pain in Pediatric Inflammatory Bowel Disease.

Inflamm Bowel Dis 2020 May 27. Epub 2020 May 27.

Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, Washington, USA.

Background: Pain is a common symptom in pediatric inflammatory bowel disease (IBD) and is associated with poor health outcomes, yet additional knowledge about the psychosocial correlates of pain is needed to optimize clinical care. The purpose of this study is to systematically review the psychosocial factors associated with pain and pain impact in youth diagnosed with IBD within a developmentally informed framework.

Methods: Manual and electronic searches yielded 2641 references. Read More

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http://dx.doi.org/10.1093/ibd/izaa115DOI Listing

The ameliorative effect of Lactobacillus plantarum-12 on DSS-induced murine colitis.

Food Funct 2020 May 27. Epub 2020 May 27.

School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, P. R. China.

Some strains of lactobacilli can exert beneficial effects on a host when ingested in an adequate dose, such as immunoregulation and anti-inflammatory activities. In this study, the survival abilities under simulated gastrointestinal conditions, adhesion abilities on HT-29 cell monolayers, and hemolytic activities of four Lactobacillus plantarum strains were assessed. Among the four strains, L. Read More

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http://dx.doi.org/10.1039/d0fo00007hDOI Listing