206,824 results match your criteria Ulcerative Colitis


Psychometric validation of the work productivity and activity impairment questionnaire in ulcerative colitis: results from a systematic literature review.

J Patient Rep Outcomes 2018 Dec 13;2(1):62. Epub 2018 Dec 13.

Pfizer, 235 42nd Street, New York, NY, 10017, USA.

Patients with ulcerative colitis, a type of inflammatory bowel disease, report negative impacts of disease symptoms on work-related outcomes, including absenteeism and presenteeism. As a way to better understand the impact of this disease and its treatment on work-related outcomes, the current review examines the use of the Work Productivity and Activity Impairment Questionnaire (WPAI), a patient-reported outcomes measure of absenteeism, presenteeism, and impairment in other activities, in studies of patients with ulcerative colitis. This review assesses the measurement properties of the WPAI in this patient population: its reliability, construct validity, ability to detect change, and responsiveness to effective treatments. Read More

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December 2018
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Internal Hernia Associated with Colostomy After Laparoscopic Surgery for Rectal Malignancy: A Report of 3 Thought-Provoking Cases.

Am J Case Rep 2018 Dec 14;19:1488-1494. Epub 2018 Dec 14.

Department of Digestive Surgery, Tenri Hospital, Tenri, Nara, Japan.

BACKGROUND Colostomy creation via intraperitoneal route is often performed during laparoscopic Hartmann's operation or abdominoperineal resection (APR). Herein, we report 3 rare cases of internal hernia associated with colostomy (IHAC). CASE REPORT The first case involved a 70-year-old man with IHAC after laparoscopic APR. Read More

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December 2018

Integrative approach for diabetic foot management- a case report.

J Ayurveda Integr Med 2018 Dec 10. Epub 2018 Dec 10.

Institute of Ayurveda and Integrative Medicine, Trans Disciplinary University, No.74/2, Jarakabandekaval Post Attur, Via Yelahanka, Bangalore, 560 064, Karnataka, India.

Non-healing diabetic foot has always demanded more attention from the surgeon due to the distinct problem it possesses. There is a constant need for the evolvement in the management and this case is one such attempt. A 62-year-old male patient with a history of diabetes mellitus since 10 years presented with a non-healing foot ulcer since 1 month. Read More

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December 2018

Randomized sham-controlled trial of the 6-month swallowable gas-filled intragastric balloon system for weight loss.

Surg Obes Relat Dis 2018 Dec 29;14(12):1876-1889. Epub 2018 Sep 29.

Stony Brook Medicine, Stony Brook, New York.

Background: Obesity is a significant health problem and additional therapies are needed to improve obesity treatment.

Objective: Determine the efficacy and safety of a 6-month swallowable gas-filled intragastric balloon system for weight loss.

Setting: Fifteen academic and private practice centers in the United States. Read More

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December 2018

A comparative study of the gut microbiota in immune-mediated inflammatory diseases-does a common dysbiosis exist?

Microbiome 2018 Dec 13;6(1):221. Epub 2018 Dec 13.

University of Manitoba IBD Clinical and Research Centre, Winnipeg, MB, Canada.

Background: Immune-mediated inflammatory disease (IMID) represents a substantial health concern. It is widely recognized that IMID patients are at a higher risk for developing secondary inflammation-related conditions. While an ambiguous etiology is common to all IMIDs, in recent years, considerable knowledge has emerged regarding the plausible role of the gut microbiome in IMIDs. Read More

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December 2018

Mesalazine treatment causing resolution of intracranial hypertension secondary to ulcerative colitis: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13365

Department of Ophthalmology, Fondation Ophtalmologique Adolphe de Rothschild.

Rationale: The association between intracranial hypertension (ICH) and ulcerative colitis (UC) is rare. We report the unusual case of a male patient with UC and ICH in whom both conditions resolved with mesalazine therapy.

Patient Concerns: A 48-year-old Caucasian man presented to our department in June 2016 for decreased vision, transient visual obscuration, pulsatile tinnitus and headaches of 7 months duration. Read More

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December 2018

Primary cutaneous anaplastic large cell lymphoma arising from a long-standing erythema nodosum: A case report.

Medicine (Baltimore) 2018 Dec;97(49):e13211

Department of Hematology.

Rationale: Primary cutaneous anaplastic large cell lymphoma (pcALCL) is a rare subtype of non-Hodgkin lymphoma, which is rarely associated with erythema nodosum (EN).

Patient Concerns: A 57-year-old woman complained of recurrent rashes involving her abdomen, back, upper and lower limbs for over 20 years, with severity in symptoms for 2 weeks.

Diagnoses: The first skin biopsy was performed in 2011 in another hospital and she was diagnosed idiopathic EN. Read More

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December 2018

[The ISAR-positive patient in urology].

Aktuelle Urol 2018 Dec 13. Epub 2018 Dec 13.

Universität Witten/Herdecke, Lehrstuhl für Geriatrie, Witten.

Background:  Since 2015 so-called "ISAR Screening" (Identification of Seniors at Risk) is mandatory for patients older than 75 years being hospitalised in Germany. It remains unclear how these patients identified as suffering from geriatric diseases are further characterised in urology and how this information is applied in the ongoing clinical treatment.

Methods:  From the July 1st to December 31th 2016, 337 patients older than 75 years were subjected to ISAR-screening. Read More

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December 2018

The risk of inflammatory bowel disease in subjects presenting with perianal abscess: findings from the THIN database.

J Crohns Colitis 2018 Dec 13. Epub 2018 Dec 13.

Department of Gastroenterology, Sandwell and West Birmingham Hospitals NHS Trust, UK.

Background: Perianal abscess (PA) is associated with inflammatory bowel disease (IBD). The incidence of IBD after a diagnosis of PA and potential predictors of a future diagnosis of IBD are unknown.

Methods: The Health Improvement Network (THIN) is a primary care database representative of the UK population. Read More

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December 2018

Multiple Cytokine Profiling: A New Model to Predict Response to Tumor Necrosis Factor Antagonists in Ulcerative Colitis Patients.

Inflamm Bowel Dis 2018 Dec 13. Epub 2018 Dec 13.

A.N. Ryzhikh State Scientific Centre for Coloproctology, Moscow, Russian Federation.

Background And Aims: Ulcerative colitis (UC) is a form of inflammatory bowel disease, and antibodies against tumor necrosis factor (anti-TNF) are used for treatment. Many patients are refractory or lose response to anti-TNF, and predicting response would be an extremely valuable clinical tool. Unlike most biomarkers, cytokines directly mediate inflammation, and their measurement may predict the likelihood of response or no response. Read More

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December 2018

Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis.

Int Immunopharmacol 2018 Dec 10;67:129-137. Epub 2018 Dec 10.

Department of Gastroenterology, Affiliated Hospital of Nanjing University of Traditional Chinese Medicine (Jiang Su Province Hospital of Traditional Chinese Medicine), Nanjing 210029, China. Electronic address:

Gallic acid (GA), as an active component, has been found in many fruits and plants, and it exhibits potential protective effects, such as anti-inflammatory, antioxidant, antiviral and anticancer. However, the effects of GA on ulcerative colitis (UC) remain unknown. The purpose of this study was to investigate the effects of GA on IL-1β-induced HIEC-6 cells and TNBS-induced UC in mice. Read More

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December 2018

The loss of tolerance to CHI3L1 - A putative role in inflammatory bowel disease?

Clin Immunol 2018 Dec 10. Epub 2018 Dec 10.

Institute for Biotechnology, Faculty of Environment and Natural Sciences, Brandenburg University of Technology Cottbus-Senftenberg, Universitätsplatz 1, 01968 Senftenberg, Germany. Electronic address:

The incidence of inflammatory bowel disease (IBD) is steadily increasing. IBD is characterized by a chronic inflammation of the gastrointestinal tract and is classified into the two main groups Crohn's disease (CD) and ulcerative colitis (UC). Genetic predispositions, environmental factors and a dysregulated immune response are known to part take in the onset of IBD. Read More

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December 2018

A polysaccharide from cultured mycelium of Hericium erinaceus relieves ulcerative colitis by counteracting oxidative stress and improving mitochondrial function.

Int J Biol Macromol 2018 Dec 10. Epub 2018 Dec 10.

Affiliated Hospital, Changchun University of Chinese Medicine, Changchun 130021, China; Jilin Provincial Key Laboratory of BioMacromolecules of Chinese Medicine, Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun 130021, China. Electronic address:

EP-1 is a polysaccharide with a molecular weight of approximately 3100 Da, which is extracted from the cultured mycelium of Hericium erinaceus. Its anti-ulcerative colitis activity was evaluated in experimental systems using rats with ulcerative colitis and Caco-2 cells as models for experimentation. Our results showed that the treatment of EP-1 could increase SOD enzyme activity as well as decrease ROS content and oxidative damage both in vivo and in vitro. Read More

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December 2018

Characterization of sulfated polysaccharide from Laurencia obtusa and its apoptotic, gastroprotective and antioxidant activities.

Int J Biol Macromol 2018 Dec 10. Epub 2018 Dec 10.

Laboratoire de Développement Chimique, Galénique et Pharmacologique des Médicaments (LR12ES09), Unité de Pharmacologie Marine, Faculté de Pharmacie de Monastir, Université de Monastir, 5000 Monastir, Tunisia. Electronic address:

This study was designed to characterize the physico-chemical properties of the sulfated polysaccharide (SP) isolated from the red alga Laurencia obtusa and to evaluate its apoptotic, gastroprotective and antioxidant activities. The different macromolecular characteristics of SP were determined by size exclusion chromatography combined with multi-angle laser light-scattering detection (SEC-MALLS), Fourier transform infrared spectroscopy (FTIR) analysis and nuclear magnetic resonance spectroscopy (H NMR and C NMR). The native molecular weight of the extracted polysaccharide is high (≥336,900 g·mol). Read More

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December 2018

Infliximab trough levels are decreasing over time in patients with inflammatory bowel disease on maintenance treatment with infliximab.

Eur J Gastroenterol Hepatol 2018 Dec 12. Epub 2018 Dec 12.

Departments of Gastroenterology.

Background: Infliximab trough levels (IFX-TLs) and antibodies to infliximab (ATIs) have been suggested as useful markers for the optimization of treatment in inflammatory bowel disease (IBD). We aimed to estimate the patterns over time of IFX-TLs and ATIs in IBD patients on maintenance treatment with IFX.

Methods: Two different measurements of IFX-TLs and ATIs were performed (ELISA; Eagle BioSciences) at a 10-month interval using serum samples of consecutive patients on maintenance treatment with IFX. Read More

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December 2018

Recognizing Congenital Pressure Injuries: A Case Series.

Authors:
Deanna E Johnson

J Wound Ostomy Continence Nurs 2018 Dec 10. Epub 2018 Dec 10.

Deanna E. Johnson, MA, APRN, NNP-BC, CWON, Children's Hospital and Clinics, Minneapolis, Minnesota.

Background: Soft tissue injuries recognized at birth are a common occurrence and well described in the medical literature. Despite this, there has been no discussion of congenital pressure injuries. In this Clinical Challenges article, I describe 3 cases in which congenital skin injuries have occurred, all of which meet the National Pressure Ulcer Advisory Panel definition for a pressure injury and are demonstrably not the result of other etiologies. Read More

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December 2018

COMPASS for Vascular Surgeons: Practical Considerations.

Curr Opin Cardiol 2018 Dec 12. Epub 2018 Dec 12.

Department of Surgery, University of Toronto.

Purpose Of Review: To suggest a practical approach for the application of data from the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) trial in patients with peripheral artery disease (PAD).

Recent Findings: The COMPASS trial showed that low-dose rivaroxaban 2.5 mg twice daily plus daily aspirin was superior to aspirin alone in reducing major adverse cardiovascular and cerebrovascular events, and major adverse limb events among patients with stable atherosclerotic vascular disease, including those with PAD. Read More

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December 2018

Evaluation of TurboHawk Plaque Rotation System in Treatment of Superficial Femoral Atherosclerosis.

Med Sci Monit 2018 Dec 13;24:9026-9031. Epub 2018 Dec 13.

Department of Vascular Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang, China (mainland).

BACKGROUND To investigate the curative effect and utility of the TurboHawk plaque circumcision system in the treatment of patients with superficial femoral atherosclerosis (SFA). MATERIAL AND METHODS We retrospectively analyzed 60 cases of superficial femoral atherosclerotic stenosis and occlusion treated with the TurboHawk plaque circumcision system for endovascular ablation of the superficial femoral artery in the People's Hospital of Xinjiang Uygur Autonomous Region between January 2016 and December 2017. RESULTS The sample comprised of 50 male and 10 female patients with an average age of 65±4. Read More

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December 2018

Marginal ulcer continues to be a major source of morbidity over time following gastric bypass.

Surg Endosc 2018 Dec 12. Epub 2018 Dec 12.

Division of Bariatric, Foregut and Advanced Gastrointestinal Surgery, Department of Surgery, Stony Brook University Medical Center, 100 Nicolls Road, HSC T19, Stony Brook, NY, 11794, USA.

Background: Marginal ulcerations (MU) are a common and concerning complication following Roux-en-Y gastric bypass (RYGB) surgery. The aim of the present study was to examine the progression of MU and identify risk factors for the need for surgical intervention in patients with MU following RYGB.

Methods: A New York state longitudinal administrative database was queried to identify patients who underwent RYGB between 2005 and 2010 and who were followed for at least 4 years for the development of MU using ICD-9 and CPT codes. Read More

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December 2018

Interleukin 12B mRNA level and rs3212227 genotyping in peripheral blood mononuclear cells of inflammatory bowel disease patients

Turk J Med Sci 2018 12 12;48(6):1147-1152. Epub 2018 Dec 12.

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Background/aim: Inflammatory bowel disease (IBD) is a multifactorial disorder. Single nucleotide polymorphisms (SNPs) in the IL-12 gene, which are the main factors to regulate the immune reaction, play an important role in the production of IL-12 molecules. The aim of this study was to evaluate the correlation between the SNP on position +1188 of the 3 ′ UTR region of the IL-12 p40 subunit gene and expression of the IL-12 p40 gene. Read More

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December 2018

The novel latex agglutination turbidimetric immunoassay system for simultaneous measurements of calprotectin and hemoglobin in feces.

Intest Res 2018 Dec 14. Epub 2018 Dec 14.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background/aims: Fecal calprotectin (Fcal) as well as the fecal immunochemical test (FIT) are useful biomarkers for detecting activity and mucosal healing in inflammatory bowel diseases. Here, we report the performance of simultaneous measurements of Fcal and FIT for ulcerative colitis (UC) patients using the newly-developed latex agglutination turbidimetric immunoassay (LATIA) system.

Methods: Fcal and hemoglobin were measured by the LATIA system in 152 UC patients who underwent colonoscopy. Read More

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December 2018

Randomized, crossover questionnaire survey of acceptabilities of controlled-release mesalazine tablets and granules in ulcerative colitis patients.

Intest Res 2018 Dec 14. Epub 2018 Dec 14.

Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan.

Background/aims: Oral mesalazine is an important treatment for ulcerative colitis (UC), and non-adherence to mesalazine increases the risk of relapse. Controlled-release (CR) mesalazine has 2 formulations: tablets and granules. The relative acceptabilities of these formulations may influence patient adherence; however, they have not been compared to date. Read More

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December 2018

Overlap Syndrome-Systemic Sclerosis, Systemic Lupus Erythematosus and Dermatomyositis - Case Report.

Curr Health Sci J 2015 Jul-Sep;41(3):269-273. Epub 2015 Mar 15.

4University of Medicine and Pharmacy of Craiova, Rheumatology Department.

Overlap syndrome is often defined as an entity that satisfies the classification criteria for at least two distinct connective tissue disease. We present the case of a female patient, 39 years old, hospitalized in the Dermatology clinic of Emergency County Hospital in september 2014, for ulcerative lesions on the left hallux and the second and third left toes, associated with pain and difficulties in walking. After performing the clinical exam and paraclinical tests, we decided for both intravenous synthetic analogue of prostacyclin PGI2-iloprost and local therapeutic measures, with a favourable outcome of the ulcerations. Read More

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The Crohn's & Colitis Australia Inflammatory Bowel Disease Audit: Measuring the quality of care in Australia.

Intern Med J 2018 Dec 7. Epub 2018 Dec 7.

The Canberra Hospital - Gastroenterology, PO Box 11 Woden Canberra, Australian Capital Territory, 2606, Australia.

Objectives: To audit the quality of care received by patients admitted for inflammatory bowel disease (IBD) across Australia against national IBD Standards.

Design: Retrospective cross-sectional survey and clinical audit assessing organisational resources, clinical processes and outcome measures.

Setting: Australian hospitals. Read More

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December 2018

Subclinical Cardiac Dysfunction Is Associated With Extracardiac Organ Damages.

Front Med (Lausanne) 2018 20;5:323. Epub 2018 Nov 20.

Cardiology Department, Hôpital Européen Georges Pompidou, Assistance Publique des Hôpitaux de Paris and UMR_S970, Université Paris Descartes, Inserm, Paris, France.

Several studies conducted in America or Europe have described major cardiac remodeling and diastolic dysfunction in patients with sickle cell disease (SCD). We aimed at assessing cardiac involvement in SCD in sub-Saharan Africa where SCD is the most prevalent. In Cameroon, Mali and Senegal, SCD patients and healthy controls of the CADRE study underwent transthoracic echocardiography if aged ≥10 years. Read More

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November 2018

Disease-Specific Enteric Microbiome Dysbiosis in Inflammatory Bowel Disease.

Front Med (Lausanne) 2018 20;5:304. Epub 2018 Nov 20.

Department of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, Denmark.

Inflammatory Bowel disease (IBD) is traditionally divided into Crohn's disease (CD) and ulcerative colitis (UC). UC is a relapsing non-transmural inflammatory disease that is restricted to the colon and is characterized by flare-ups of bloody diarrhea. CD is a chronic, segmental localized granulomatous disease that can affect any part of the entire gastrointestinal tract. Read More

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November 2018

The possibility of using shogaol for treatment of ulcerative colitis.

Iran J Basic Med Sci 2018 Sep;21(9):943-949

Department of Anatomy and Pathology, College of Veterinary Medicine, Sulaimani University, Kurdistan, Iraq.

Objectives: This study aimed to investigate the effect of Shogaol on dextran sodium sulfate (DSS)- induced ulcerative colitis (UC) in mice compared to an immune-suppressant chemotherapeutic medicine, known as 6-thioguanine (6-TG).

Materials And Methods: Thirty-six adult BALB/c mice were divided into six groups: group 1 (positive control): no DSS exposure and no treatment; group 2 (negative control): DSS exposure without treatment; group 3 (vehicle control): DSS exposure and olive oil treatment; group 4: DSS exposure and 0.3 mg/kg 6-TG treatment; group 5: DSS exposure and 20 mg/kg Shogaol treatment; and group 6: DSS exposure and 40 mg/kg Shogaol treatment. Read More

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September 2018

Laparoscopic repair of a perforated duodenal ulcer: another use of a round ligament flap.

Wideochir Inne Tech Maloinwazyjne 2018 Dec 30;13(4):542-545. Epub 2018 May 30.

Department of Digestive Surgery, Amiens University Hospital, Amiens, France.

Management of a perforated duodenal ulcer is most commonly performed by laparoscopy and consists of suture of the perforation after performing lavage of the peritoneal cavity. In most cases, a flap is created, and an omental flap is usually the preferred choice because of its simplicity and its proximity to the site of duodenal perforation. However, in some cases, the greater omentum cannot be used due to the severity of peritonitis or due to previous surgical removal. Read More

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December 2018

Factors Associated with Recurrent Ulcers in Patients with Gastric Surgery after More Than 15 Years: A Cross-Sectional Single-Center Study.

Gastroenterol Res Pract 2018 4;2018:8319481. Epub 2018 Nov 4.

Department of Medical Informatics and Biostatistics, University of Medicine and Pharmacy "Iuliu Hațieganu", Louis Pasteur St., No. 6, 400349 Cluj-Napoca, Romania.

Aim: We aimed to establish the independent predictive factors (from infection, biliary reflux, histologic features of the gastric mucosa, drugs, comorbidities, and social habits) for gastric stump ulcer occurrence more than 15 years after surgery.

Methods: 76 patients with previous gastric surgery were included: 21 patients with gastric ulcer (marginal ulcer or ulcer of the rest of the gastric remnant-study group) and 55 controls (nonulcer group).

Results: infection tended to be higher in the control group than in the ulcer group (14. Read More

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November 2018

Effects of Appendectomy on the Onset and Course of Ulcerative Colitis in Chinese Patients.

Gastroenterol Res Pract 2018 6;2018:2927891. Epub 2018 Nov 6.

Department of Gastroenterology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Previous epidemiological studies have suggested that appendectomy may be a protective factor against the development of ulcerative colitis (UC). However, the results of these studies were inconsistent, with rare studies in Chinese populations.

Aim: This study examined the associations between appendectomy performed before UC diagnosis and the occurrence and clinical course of UC in Chinese patients. Read More

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November 2018

The Impact of Stress on Pressure Ulcer Wound Healing Process and on the Psychophysiological Environment of the Individual Suffering from them.

Med Arch 2018 Nov;72(5):362-366

Nursing Program and Postgraduate program Contemporary Nursing, University of Nicosia, Nicosia, Cyprus.

Introduction: The occurrence of a pressure ulcer constitutes a major psychological and physiological burden and it has been linked with a reduced quality of life and increased stress of the individual.

Objective: The main objective was to investigate the impact that stress has on pressure ulcer healing process and on the psychophysiological environment of the individual suffering from them.

Method: The scientific literature was reviewed through Cinahl, Pub-med, EBSCO, Medline and Google scholar. Read More

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November 2018

Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H/K-ATPase and mitochondrial-mediated signaling pathway.

J Nat Med 2018 Dec 6. Epub 2018 Dec 6.

Hubei Key Laboratory of Natural Products Research and Development, College of Biological and Pharmaceutical Sciences, China Three Gorges University, 8 University Avenue, Yichang, 443002, China.

The aim of this study was to elucidate the gastroprotective activity and possible mechanism of involvement of araloside A (ARA) against ethanol- and aspirin-induced gastric ulcer in mice. The experimental mice were randomly divided into control, model, omeprazole (20 mg/kg, orally) and ARA (10, 20 and 40 mg/kg, orally). Gastric ulcer in mice was induced by intragastric administration of 80% ethanol (10 mL/kg) containing 15 mg/mL aspirin 4 h after drug administration on day 7. Read More

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December 2018

Guideline recommendations for treatment of patients with inflammatory bowel diseases are not implemented in clinical practice-results of a non-representative survey.

Int J Colorectal Dis 2018 Dec 7. Epub 2018 Dec 7.

Medizinische Klinik m. S. Gastroenterologie, Infektiologie und Rheumatologie, Campus Benjamin Franklin, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Hindenburgdamm 30, 12200, Berlin, Germany.

Purpose: There is a growing evidence for over-, under-, or misuse of health care in patients with inflammatory bowel disease. Most studies looked at treatment variability or used quality measures, which mostly capture supportive interventions rather than treatment of IBD in itself. We aimed to evaluate if current recommendations in clinical practice guidelines regarding the medical treatment of patients with inflammatory bowel diseases are being followed in Germany. Read More

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December 2018

The emerging role of lncRNAs in inflammatory bowel disease.

Exp Mol Med 2018 Dec 6;50(12):161. Epub 2018 Dec 6.

Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Copenhagen, Denmark.

Dysregulation of long noncoding RNA (lncRNA) expression is linked to the development of various diseases. Recently, an emerging body of evidence has indicated that lncRNAs play important roles in the pathogenesis of inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative Colitis (UC). In IBD, lncRNAs have been shown to be involved in diverse processes, including the regulation of intestinal epithelial cell apoptosis, association with lipid metabolism, and cell-cell interactions, thereby enhancing inflammation and the functional regulation of regulatory T cells. Read More

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December 2018

Mortality rate and risk factors for gastrointestinal bleeding in elderly patients.

Eur J Intern Med 2018 Dec 4. Epub 2018 Dec 4.

First Department of Internal Medicine, San Matteo Hospital Foundation, University of Pavia, Pavia, Italy.

Background: Gastrointestinal bleeding (GIB) is burdened by high mortality rate that increases with aging. Elderly patients may be exposed to multiple risk factors for GIB. We aimed at defining the impact of GIB in elderly patients. Read More

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December 2018

T cell-lymphoma in the eyelid of a 9-year-old English Setter.

Acta Vet Scand 2018 Dec 6;60(1):79. Epub 2018 Dec 6.

Eye Pathology Section, Department of Pathology, Rigshospitalet, Faculty of Health and Medical Sciences, University of Copenhagen, Frederik V's Vej, 11, 1st Floor, 2100, Copenhagen Ø, Denmark.

Background: Eyelid tumours are frequently found in dogs, most of these being benign. In case of an ulcerating eyelid tumour, malignancy must be considered. We report a unique case of a low-grade peripheral T-cell lymphoma in the eyelid of a 9-year-old English Setter. Read More

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December 2018

Characterization of inflammatory infiltrate of ulcerative dermatitis in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice.

Lab Anim 2018 Dec 6:23677218815718. Epub 2018 Dec 6.

1 Department of Veterinary Medicine and Animal Production, University of Naples Federico II, Italy.

Ulcerative dermatitis (UD) is an idiopathic, spontaneous and progressive disease typically affecting C57BL/6 aged mice with an unknown aetiopathogenesis. For this study, we evaluated 25 cases of UD in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice. Formalin-fixed, paraffin-embedded skin samples were submitted to morphological investigations. Read More

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December 2018

Shorter Relapse-Free Period after Leukocyte Removal Therapy in Younger than Older Patients with Ulcerative Colitis.

Digestion 2018 Dec 12:1-7. Epub 2018 Dec 12.

Department of Internal Medicine, Saga Medical School, Saga, Japan.

Background: Leukocyte removal therapy (LRT) is an effective treatment for active ulcerative colitis (UC). The present study was performed to evaluate the relapse-free period after LRT and identify risk factors for relapse.

Methods: In total, 94 patients who underwent first-time LRT for remission of moderate to severe UC from April 2004 to March 2016 were enrolled in the present study. Read More

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December 2018
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Myeloid-Derived Suppressor Cells Produce IL-10 to Elicit DNMT3b-Dependent IRF8 Silencing to Promote Colitis-Associated Colon Tumorigenesis.

Cell Rep 2018 Dec;25(11):3036-3046.e6

Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA; Georgia Cancer Center, Augusta University, Augusta, GA 30912, USA; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA. Electronic address:

IL-10 functions as a suppressor of colitis and colitis-associated colon cancer, but it is also a risk locus associated with ulcerative colitis. The mechanism underlying the contrasting roles of IL-10 in inflammation and colon cancer is unknown. We report here that inflammation induces the accumulation of CD11bGr1 myeloid-derived suppressor cells (MDSCs) that express high levels of IL-10 in colon tissue. Read More

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December 2018

Fecal Microbiota Transplantation for Recurrent Clostridium difficile Infection and Other Conditions in Children: A Joint Position Paper From the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition.

J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.

Section of Pediatric Gastroenterology and Nutrition, Texas Children's Hospital, Baylor College of Medicine, Children's Nutrition and Research Center, Houston, TX.

Fecal microbiota transplantation (FMT) is becoming part of the treatment algorithms against recurrent Clostridium difficile infection (rCDI) both in adult and pediatric gastroenterology practice. With our increasing recognition of the critical role the microbiome plays in human health and disease, FMT is also being considered as a potential therapy for other disorders, including inflammatory bowel disease (Crohn disease, ulcerative colitis), graft versus host disease, neuropsychiatric diseases, and metabolic syndrome. Controlled trials with FMT for rCDI have not been performed in children, and numerous clinical and regulatory considerations have to be considered when using this untraditional therapy. Read More

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December 2018

Abnormal Pouchogram Predicts Pouch Failure Even in Asymptomatic Patients.

Dis Colon Rectum 2018 Nov 28. Epub 2018 Nov 28.

Background: Anastomotic complications after restorative total proctocolectomy with IPAA for ulcerative colitis alter functional outcomes and quality of life and may lead to pouch failure. Routine contrast enema of the pouch assesses anastomotic integrity before ileostomy reversal, but its clinical use is challenged.

Objective: The purpose of this research was to assess the relationship among preoperative clinical characteristics, abnormal pouchography, and long-term pouch complications. Read More

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November 2018

THE ONSET OF CLINICAL MANIFESTATIONS IN INFLAMMATORY BOWEL DISEASE PATIENTS.

Arq Gastroenterol 2018 Jul-Sep;55(3):290-295

Universidade do Estado da Bahia, Departamento de Ciências da Vida, Salvador, BA, Brasil.

Background: The diagnosis of inflammatory bowel disease is often delayed because of the lack of an ability to recognize its major clinical manifestations.

Objective: Our study aimed to describe the onset of clinical manifestations in inflammatory bowel disease patients.

Methods: A cross-sectional study. Read More

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October 2017

VITAMIN D DEFICIENCY AMONG INFLAMMATORYBOWEL DISEASE PATIENTS IN ARGENTINA: A CROSS-SECTIONAL STUDY.

Arq Gastroenterol 2018 Jul-Sep;55(3):216-220

Gastroenterology Department, Hospital Británico de Buenos Aires, Buenos Aires, Argentina.

Background: An association has been established between low serum values of vitamin D and inflammatory bowel disease. There is a lack of evidence on whether this association is still observed in regions where sun exposure throughout the year is higher.

Objective: To compare the prevalence of vitamin D deficiency between inflammatory bowel disease patients and healthy controls. Read More

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January 2018

INFLAMMATORY BOWEL DISEASE: IMPACT ON SCORES OF QUALITY OF LIFE, DEPRESSION AND ANXIETY IN PATIENTS ATTENDING A TERTIARY CARE CENTER IN BRAZIL.

Arq Gastroenterol 2018 Jul-Sep;55(3):202-207

Programa de Pós-Graduação: Ciências da Gastroenterologia e Hepatologia, Hospital de Clínicas de Porto Alegre, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.

Background: Inflammatory bowel disease frequently affects patients at working age, compromising their quality of life in several levels: physical, psychological, familial and social. Few studies have evaluated the impact of Inflammatory bowel disease on quality of life, anxiety and depression in Brazilian patients.

Objective: Evaluate quality of life and its correlation with psychological aspects of patients with inflammatory bowel disease through the Inflammatory Bowel Disease Questionnaire and Hospital Anxiety and Depression Scale. Read More

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November 2017

Technical variations and feasibility of transanal ileal pouch-anal anastomosis for ulcerative colitis and inflammatory bowel disease unclassified across continents.

Tech Coloproctol 2018 Dec 11. Epub 2018 Dec 11.

Cedars Sinai Medical Center, 8737 Beverly Blvd. Suite 101, Los Angeles, CA, 90048, USA.

Purpose: Initial reports of transanal ileal pouch-anal anastomosis (taIPAA) suggest safety and feasibility compared with transabdominal IPAA. The purpose of this study was to evaluate differences in technique and results of taIPAA in three centers performing taIPAA across two continents.

Methods: Prospective IPAA registries from three institutions in the US and Europe were queried for patients undergoing taIPAA. Read More

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December 2018

Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies.

Osteoporos Int 2018 Dec 12. Epub 2018 Dec 12.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, 250 Wu-Hsing St., Taipei, 110, Taiwan.

We performed a meta-analysis of relevant studies to quantify the magnitude of the association between proton pump inhibitors (PPIs) and risk of hip fracture. Patients with PPIs had a greater risk of hip fracture than those without PPI therapy (RR 1.20, 95% CI 1. Read More

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December 2018

Endoscopic suturing for management of peptic ulcer-related upper gastrointestinal bleeding: a preliminary experience.

Endosc Int Open 2018 Dec 10;6(12):E1439-E1444. Epub 2018 Dec 10.

Division of Gastroenterology, Johns Hopkins Hospital, Baltimore, MD.

Acute non-variceal upper gastrointestinal bleeding (UGIB) due to peptic ulcer disease (PUD) remains a common and challenging emergency managed by gastroenterologists. The proper role of endoscopic suturing on the management of PUD-related UGIB is unknown.  This is an international case series of patients who underwent endoscopic suturing for bleeding PUD. Read More

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December 2018

School-related experience and performance with inflammatory bowel disease: results from a cross-sectional survey in 675 children and their parents.

BMJ Open Gastroenterol 2018 24;5(1):e000236. Epub 2018 Nov 24.

Division of Epidemiology and Biometry, Medical Faculty, Carl von Ossietzky University Oldenburg, Oldenburg, Germany.

Objective: We describe school performance and experience in children with inflammatory bowel disease (IBD) across Germany and Austria. Predictors of compromised performance and satisfaction were evaluated to identify subgroups of increased risk.

Design: This cross-sectional analysis was based on a postal survey in children aged 10-15 with Crohn's disease, ulcerative colitis or unclassified IBD and their families. Read More

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November 2018

Endoscopic Injection of Mitomycin C for the Treatment of Pharyngoesophageal Stenosis Refractory to Endoscopic Treatment with Dilatation in Patients Treated for Head and Neck Cancer.

Gastroenterol Res Pract 2018 12;2018:5428157. Epub 2018 Nov 12.

Department of Gastroenterology, Endoscopy Unit of the Cancer Institute of São Paulo-ICESP, Brazil.

Background: Management of pharyngoesophageal stenosis (PES) in patients after head and neck cancer (HNC) treatment remains a challenge. It is not uncommon that PES is refractory to dilation sessions. This study aimed at evaluating the efficacy of Mitomycin C (MMC) endoscopic injection for the treatment of refractory pharyngoesophageal stenosis. Read More

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November 2018

Nurses' knowledge on pressure injury prevention: a systematic review and meta-analysis based on the Pressure Ulcer Knowledge Assessment Tool.

Clin Cosmet Investig Dermatol 2018 23;11:613-620. Epub 2018 Nov 23.

Department of Nursing, School of Nursing and Midwifery, Kurdistan University of Medical Sciences, Sanandaj, Iran,

Introduction: Inadequate knowledge on pressure injury (PI) can have a detrimental effect on preventive care strategies. The aim of this study was to assess the overall knowledge of nurses on PI prevention based on their scores on the Pressure Ulcer Knowledge Assessment Tool (PUKAT) and its subscales in different settings.

Methods: In this systematic review and meta-analysis, databases including Web of Science, Science Direct, Google Scholar, PubMed, and Scopus were searched, using the following keywords: Pressure Ulcer, Pressure injury, Bedsore, Pressure Sore, Decubitus Ulcer, knowledge, and their possible combinations. Read More

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November 2018