6,697 results match your criteria Typhus


GroEL is an immunodominant surface-exposed antigen of Rickettsia typhi.

PLoS One 2021 10;16(6):e0253084. Epub 2021 Jun 10.

Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

Rickettsioses are neglected and emerging potentially fatal febrile diseases that are caused by obligate intracellular bacteria, rickettsiae. Rickettsia (R.) typhi and R. Read More

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Scrub typhus and antibiotic-resistant .

Expert Rev Anti Infect Ther 2021 Jun 10. Epub 2021 Jun 10.

Department of Laboratory Medicine, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan.

: Scrub typhus is one of the most underdiagnosed and under-reported febrile illnesses requiring hospitalization, mainly occurring in Southeast and East Asia and the Pacific Islands, in an area referred to as the "Tsutsugamushi Triangle." Scrub typhus is a zoonotic rickettsial disease that is transmitted to humans by trombiculid mites.: A MEDLINE/PubMed search of the available literature was performed to describe the role of antibiotic-resistant scrub typhus in therapy failure. Read More

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Analysis of the epidemiological and clinical characteristics of 65 patients with scrub typhus on the east coast of China.

Ann Palliat Med 2021 May;10(5):5694-5705

Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong, China.

Background: The present study set out to investigate the epidemiological and clinical characteristics of 65 patients with tsutsugamushi disease.

Methods: The clinical data of 65 patients with tsutsugamushi disease, who were admitted to the Affiliated Hospital of Nantong University were retrospectively analyzed. The clinical symptoms, laboratory examination results, clinical treatment plans, treatments, and outcomes of the patients were analyzed. Read More

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A Retrospective Analysis of Outcome in Malaria Patients Admitted into a Multidisciplinary Intensive Care Unit of a Tertiary Care Teaching Hospital.

Anesth Essays Res 2020 Jul-Sep;14(3):425-427. Epub 2021 Mar 22.

Department of Critical Care Medicine, NRI Medical College, Guntur, Andhra Pradesh, India.

Introduction: Malaria is a significant public health problem with people worldwide at risk for the disease. It is a mosquito-borne disease causing high-grade fever, chills, and flu-like illness. The World Health Organization (WHO) recommends the case with severe malaria should be admitted in the intensive care unit (ICU). Read More

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Seroprevalence and Clinical Features of Scrub Typhus among Febrile Patients Attending a Referral Hospital in Kathmandu, Nepal.

Trop Med Infect Dis 2021 May 13;6(2). Epub 2021 May 13.

Central Department of Microbiology, Tribhuvan University, Kirtipur 44618, Nepal.

(1) Background: Scrub typhus (ST) is endemic to Nepal. It is often underdiagnosed and misdiagnosed due to non-specific clinical presentation coupled with limited microbiological facilities, leading to adverse clinical outcomes. This study aimed to assess the seroprevalence of scrub typhus in febrile patients attending Sukraraj Tropical and Infectious Disease Hospital (STIDH), Nepal, from August 2018 to April 2019. Read More

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Scrub typhus and lateral rectus palsy: an uncommon presentation of a common illness.

BMJ Case Rep 2021 May 31;14(5). Epub 2021 May 31.

Radiotherapy and Oncology, Indira Gandhi Medical College Cancer Hospital, Shimla, India.

Scrub typhus is a zoonosis, which usually manifests as an acute febrile illness. It is caused by a rickettsia, , which is endemic in the Asian region. It can present with varied clinical manifestations, ranging from acute febrile illness to life-threatening multiorgan dysfunction syndrome. Read More

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Small joint polyarthritis - An unusual presentation of scrub typhus in a child.

Trop Doct 2021 May 31:494755211019326. Epub 2021 May 31.

Assitant Professor, Department of Pediatrics, Saveetha Medical College & Hospital, Chennai, India.

Scrub typhus is a common Rickettsial infection which is endemic in tropical regions. It is characterised by fever, eschar, thrombocytopenia, lymphadenopathy and organomegaly. Scrub typhus has significant morbidity and mortality owing to its multisystemic involvement. Read More

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Assessing scrub typhus and rickettsioses transmission risks in the Chiang Rai province of northern Thailand.

Travel Med Infect Dis 2021 May 24;42:102086. Epub 2021 May 24.

Department of Entomology, US Medical Directorate-Armed Forces Research Institute of Medical Science, Bangkok, Thailand.

Background: Scrub typhus is an important disease in the Asia-Pacific countries with increasing relevance for public health worldwide. Entomological risk assessment for scrub typhus and rickettsial disease in Phu Chi Fah village-Chiang Rai was performed to determine areas at greatest risk for disease transmission in order to increase awareness of diseases to travelers and healthcare workers.

Methods: From 2016 to 2018, rodents and chiggers were collected from 7 sites covering residential, grassland, and forest areas to determine the prevalence of pathogen of interest. Read More

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Clinical and biochemical profile of scrub typhus patients at a tertiary care hospital in Northern India.

J Family Med Prim Care 2021 Mar 8;10(3):1459-1465. Epub 2021 Apr 8.

Department of Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India.

Background: Scrub typhus is a neglected rickettsial disease in India. Every year, we are facing outbreaks of Scrub typhus after Monsoon season. Patients present with a wide clinical spectrum ranging from pyrexia of unknown origin to multiple organ dysfunction. Read More

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High prevalence and low diversity of chigger infestation in small mammals found in Bangkok Metropolitan parks.

Med Vet Entomol 2021 May 21. Epub 2021 May 21.

Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Chiggers are recognized as vectors of scrub typhus disease caused by the bacteria, Orientia tsutsugamushi. The risk of disease exposure is mainly related to chigger bites when humans or animals roam into vector-infested habitats. In big cities, urban public parks could provide areas for the animal-human interface and zoonotic pathogen transmission. Read More

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Seroprevalence of Rickettsial Infections in Northeast India: A Population-Based Cross-Sectional Survey.

Asia Pac J Public Health 2021 May 21:10105395211015864. Epub 2021 May 21.

Indian Council of Medical Research-National Institute of Epidemiology, Chennai, India.

A cross-sectional survey was undertaken to estimate seroprevalence of immunoglobulin G antibodies against scrub typhus, spotted fever group rickettsiae, and typhus group rickettsiae in randomly selected 48 clusters in 12 districts of 3 Northeast states of India: Assam, Meghalaya, and Tripura. Individuals in 3 age groups (5-8, 9-17, and 18-45 years) were selected from each cluster. Sera (N = 2360) tested were collected as part of a national survey on dengue seroprevalence conducted between September 2017 and February 2018. Read More

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Acute kidney injury and electrolyte abnormalities in patients with scrub typhus admitted to a tertiary care hospital in southern India.

J Family Med Prim Care 2021 Jan 30;10(1):187-191. Epub 2021 Jan 30.

Department of Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

Introduction: Scrub typhus is an acute febrile illness that is seen in many parts of India. Acute kidney injury (AKI) can occur in patients with scrub typhus who are not diagnosed and treated in the early stage of the disease. Such patients can have associated electrolyte abnormalities also. Read More

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January 2021

Intranasal Vaccination with Outer-Membrane Protein of induces Protective Immunity Against Scrub Typhus.

Immune Netw 2021 Apr 3;21(2):e14. Epub 2020 Dec 3.

Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.

Scrub typhus develops after the individual is bitten by a trombiculid mite infected with . Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n. Read More

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Comparative Study of Chikungunya Only and Chikungunya-Scrub Typhus Coinfection in Children: Findings from a Hospital-Based Observational Study from Central Nepal.

Int J Pediatr 2021 20;2021:6613564. Epub 2021 Apr 20.

Centre for Population Health Research, Bhairahawa, Nepal.

Objectives: Chikungunya and scrub typhus infection are important causes of undifferentiated fever in tropical zones. The clinical manifestations in both conditions are nonspecific and often overlap. This study compares the clinical manifestations and the outcome of chikungunya with chikungunya-scrub typhus coinfection in children. Read More

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The 100 top-cited articles on scrub typhus: a bibliometric analysis.

Osong Public Health Res Perspect 2021 Apr 29;12(2):126-135. Epub 2021 Apr 29.

Key Laboratory of Environmental Medicine Engineering, Ministry of Education, Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China.

Objective: The aims of this study were to analyze the characteristics of the 100 top-cited articles on scrub typhus (ST), and to assess the present research landscape and future research directions using bibliometric analysis.

Methods: Web of Science was used to conduct a bibliometric analysis of the 100 top-cited articles on ST. The articles were analyzed by publication year, number of citations, document type, journals, keywords, institutions, country of origin, and authorship. Read More

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Association between scrub typhus encephalitis and diffusion tensor tractography detection of Papez circuit injury: A case report.

World J Clin Cases 2021 May;9(13):3194-3199

Department of Physical Medicine and Rehabilitation, University of Ulsan College of Medicine, Ulsan University Hospital, Dong-gu 44033, Ulsan, South Korea.

Background: It is difficult to restore the cognitive functions of patients with impaired cognition caused by brain injury. Diffusion tensor imaging can visualize the integrity of neural tracts in the white matter (WM) three-dimensionally. It is unclear whether encephalitis following scrub typhus damages the WM. Read More

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Tropical pyomyositis in scrub typhus: a rare association.

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Neurology, Institute of Postgraduate Medical Education and Research Bangur Institute of Neurology, Kolkata, India.

Tropical pyomyositis manifests as single or multiple abscesses inside skeletal muscles and it has a higher prevalence in immunocompromised patients. Scrub typhus, a zoonotic disease is caused by and the clinical manifestations range from simple febrile illness to organ threatening complications. Here, we present a rare case of an immunocompetent young man diagnosed as tropical pyomyositis in association with scrub typhus. Read More

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Lipid A Structural Divergence in Pathogens.

mSphere 2021 May 5;6(3). Epub 2021 May 5.

Department of Microbiology and Immunology, School of Medicine, University of Maryland Baltimore, Maryland, USA.

Species of (: ) are obligate intracellular parasites of a wide range of eukaryotes, with recognized arthropod-borne human pathogens belonging to the transitional group (TRG), typhus group (TG), and spotted fever group (SFG) rickettsiae. Growing in the host cytosol, rickettsiae pilfer numerous metabolites to make a typical Gram-negative bacterial cell envelope. The O-antigen of rickettsial lipopolysaccharide (LPS) is immunogenic and has been shown to tether the S-layer to the rickettsial surface; however, little is known about the structure and immunogenicity of the lipid A moiety. Read More

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Clinical profile and predictors of severity in paediatric scrub typhus with pulmonary involvement.

Trop Doct 2021 May 6:494755211012585. Epub 2021 May 6.

Assistant Professor, Department of Community Medicine, 483691Indira Gandhi Medical College and Research Institute, Pondicherry, India.

Pulmonary involvement is common in children with scrub typhus. Our paper outlines the clinical characteristics of pulmonary involvement and analyses the predictors of its severity. All scrub typhus serology-positive (optical density >0. Read More

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The Risk of Dengue and Scrub Typhus Overshadowed by COVID-19 in Nepal.

Authors:
Mahesh Lamsal

Asia Pac J Public Health 2021 May 3:10105395211012907. Epub 2021 May 3.

Tribhuvan University, Kirtipur, Kathmandu, Nepal.

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Spatiotemporal Dynamics of Scrub Typhus in Jiangxi Province, China, from 2006 to 2018.

Int J Environ Res Public Health 2021 04 26;18(9). Epub 2021 Apr 26.

The Collaboration Unit for Field Epidemiology of State Key Laboratory of Infectious Disease Prevention and Control, Nanchang Center for Disease Control and Prevention, Nanchang 330038, China.

: Scrub typhus (ST) has become a significant potential threat to public health in Jiangxi. Further investigation is essential for the control and management of the spatiotemporal patterns of the disease. : Time-series analyses, spatial distribution analyses, spatial autocorrelation analysis, and space-time scan statistics were performed to detect spatiotemporal dynamics distribution of the incidence of ST. Read More

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A Clinical Case of Scrub Typhus in the United States Forces Korea Patient with Eschar and Genetic Identification of Using Multiplex PCR-Based Next-Generation Sequencing.

Pathogens 2021 Apr 2;10(4). Epub 2021 Apr 2.

Department of Microbiology, College of Medicine, Korea University, Seoul 02841, Korea.

An epidemiological investigation was conducted for a scrub typhus case reported in a U.S. Forces Korea military patient in the Republic of Korea in November 2018. Read More

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Scrub Typhus and Molecular Characterization of from Central Nepal.

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

Department of Microbiology, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu 44600, Nepal.

Scrub typhus is a vector-borne, acute febrile illness caused by . Scrub typhus continues to be an important but neglected tropical disease in Nepal. Information on this pathogen in Nepal is limited to serological surveys with little information available on molecular methods to detect . Read More

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Opsoclonus-Myoclonus Syndrome as a Heralding Feature of Scrub Typhus: An Illustrative Case with a Video Vignette.

J Mov Disord 2021 May 3. Epub 2021 May 3.

Department of Neurology, Lady Hardinge Medical College, New Delhi, India.

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Secreted Wnt antagonists in scrub typhus.

PLoS Negl Trop Dis 2021 Apr 29;15(4):e0009185. Epub 2021 Apr 29.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

Background: The mechanisms that control local and systemic inflammation in scrub typhus have only been partially elucidated. The wingless (Wnt) signaling pathways are emerging as important regulators of inflammation and infection, but have not been investigated in scrub typhus.

Methodology/principal Findings: Plasma levels of secreted Wnt antagonists (i. Read More

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Ocular manifestation of rickettsial disease in South Indian population.

Indian J Ophthalmol 2021 05;69(5):1167-1171

Prasad Netralaya, Udupi, Karnataka, India.

Purpose: The aim of this work was to study the ocular manifestations and its management in spotted fever and typhus group of rickettsial disease.

Methods: A retrospective analysis of 50 patients with serologically confirmed Rickettsial disease. In all patients, relevant history, investigations and treatment details were collected and they underwent complete ophthalmic evaluation including measurement of best-corrected visual acuity, anterior segment examination and dilated fundus examination. Read More

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Scrub typhus with cerebral venous sinus thrombosis: a rare presentation.

BMJ Case Rep 2021 Apr 28;14(4). Epub 2021 Apr 28.

Neuro-Medicine, KPC Medical College and Hospital, Jadavpur, West Bengal, India

This is a rare presentation of scrub typhus with cerebral venous thrombosis. A 32-year-old woman presented with signs of raised intracranial tension. Examination revealed maculopapular skin rashes and an 'eschar' over the right thigh. Read More

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Investigations of seasonal outbreaks of acute encephalitis syndrome due to in Gorakhpur region, India: A One Health case study.

Indian J Med Res 2021 Mar;153(3):375-381

ICMR-National Institute of Epidemiology, Chennai, Tamil Nadu; Division of Epidemiology and Communicable Diseases Division , Indian Council of Medical Research, New Delhi, India.

Gorakhpur division consisting of Gorakhpur and neighboring districts Deoria, Kushinagar and Maharajganj in Uttar Pradesh, India, have been witnessing seasonal outbreaks of acute encephalitis syndrome (AES) among children for the last three decades. Investigations conducted during 2005 identified Japanese encephalitis (JE) virus as an aetiology of AES. With the introduction of JE vaccination and other control strategies, the incidence of JE in the region declined, however, outbreaks of acute febrile illness with neurological manifestations continued to occur. Read More

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Outbreak prone communicable diseases of public health importance in the northern districts of West Bengal - Current status & the way forward.

Indian J Med Res 2021 Mar;153(3):358-366

Department of Community Medicine, Armed Forces Medical College, Pune, Maharashtra, India.

India is perilously poised on the threshold of an explosion of infectious diseases, some of which have witnessed re-emergence while others await apposite opportunity to do so. The State of West Bengal is uniquely positioned with its innate geographical vulnerabilities that favour outbreaks of a host of infectious diseases. The northern districts of this State are well known endemic areas for many outbreak prone communicable diseases like malaria, Japanese encephalitis, scrub typhus, dengue and kala-azar. Read More

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Journey towards National Institute of One Health in India.

Indian J Med Res 2021 Mar;153(3):320-326

ICAR-National Research Centre on Meat, Hyderabad, Telangana, India.

Background & Objectives: Issues such as emerging and re-emerging infectious diseases, antimicrobial resistance, food security, biosafety and biosecurity are associated with changes in land use, population growth, urbanization, global travel and trade and climate change. As a result, a trans-disciplinary approach among human, animal and environmental health disciplines gained support. The Indian Council of Medical Research (ICMR) and Indian Council of Agricultural Research (ICAR) decided to establish a National Institute of One Health at Nagpur, Maharashtra, India. Read More

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