6,188 results match your criteria Typhus


Evaluation of loop-mediated isothermal amplification assay for detection of scrub typhus in patients with acute febrile illness presenting to a Tertiary Care Center in Puducherry, India.

J Lab Physicians 2019 Jan-Mar;11(1):82-86

Department of Microbiology, Pondicherry Institute of Medical Sciences, Puducherry, India.

Purpose: Scrub typhus an acute febrile illness has diverse clinical manifestations, which overlap with other febrile illnesses. Due to this reason, it is misdiagnosed, leading to inappropriate treatment, sometimes resulting in fatality. Thus, accurate diagnosis of scrub typhus is important for appropriate treatment. Read More

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http://dx.doi.org/10.4103/JLP.JLP_148_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437831PMC

Serological evidence of human leptospirosis in patients with acute undifferentiated febrile illness from Uttarakhand, India: A pilot study.

J Lab Physicians 2019 Jan-Mar;11(1):11-16

Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Context: To the best of our knowledge, there are no reports of serological evidence of human leptospirosis from Uttarakhand state in India.

Aims: The aim of this study was to screen for serological evidence of leptospirosis in patients with acute undifferentiated febrile illness at a tertiary care teaching hospital in Uttarakhand.

Settings And Design: A pilot study was conducted from March to November 2017. Read More

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http://dx.doi.org/10.4103/JLP.JLP_121_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437824PMC

Misdiagnosis of scrub typhus complicated by hemophagocytic syndrome.

BMC Pediatr 2019 Apr 10;19(1):102. Epub 2019 Apr 10.

Second Affiliated Hospital of Wenzhou Medical University, Wen Zhou, China.

Background: This study sought to analyze the cases of clinical misdiagnosis of scrub typhus complicated by hemophagocytic syndrome.

Methods: We retrospectively reviewed the medical records for diagnoses, clinical course, chest X-ray findings, laboratory data, and antibiotic therapy.

Results: All nine patients were misdiagnosed at the outpatient department between 07/2009 and 07/2017. Read More

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http://dx.doi.org/10.1186/s12887-019-1475-xDOI Listing
April 2019
1 Read

Scrub typhus infection, not a benign disease: an experience from a tertiary care center in Northern India.

Med Pharm Rep 2019 Jan 15;92(1):36-42. Epub 2019 Jan 15.

Internal Medicine Department, Pt. BD Sharma PGIMS, Rohtak, India.

Introduction: Scrub typhus is an acute febrile illness caused by . It is characterised by fever, rash, myalgia and diffuse lymphadenopathy. Most common complications are sepsis, shock, acute respiratory distress syndrome (ARDS), hepatitis, pre renal azotemia and multi organ dysfunction syndrome (MODS). Read More

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http://dx.doi.org/10.15386/cjmed-1088DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448495PMC
January 2019
3 Reads

Pulmonary Artery Thrombosis Associated with Scrub Typhus.

Infect Chemother 2019 Mar;51(1):73-76

Division of Cardiology, Department of Internal Medicine, Yeungnam University Medical Center, Daegu, Korea.

Scrub typhus is an acute febrile disease caused by , and the clinical course varies from mild and self-limiting to fatal. We describe a rare case of a pulmonary artery thrombosis associated with scrub typhus. Vasculitis via endothelial dysfunction caused by scrub typhus could be considered as the main mechanism. Read More

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http://dx.doi.org/10.3947/ic.2019.51.1.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446015PMC
March 2019
5 Reads

Seroprevalence and Risk Factors for and Infection in Four Ecologically Distinct Regions of Peru.

Am J Trop Med Hyg 2019 Apr 1. Epub 2019 Apr 1.

XXX.

and spp. are under-recognized causes of acute febrile disease worldwide. species are often placed into the spotted fever group rickettsiae (SFGR) and typhus group rickettsiae (TGR). Read More

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http://dx.doi.org/10.4269/ajtmh.18-0029DOI Listing
April 2019
1 Read
2.699 Impact Factor

Scrub typhus (Tsutsugamushi disease) in a patient presenting with hemophagocytic syndrome.

Immunol Med 2018 Jun 17;41(2):82-84. Epub 2018 Aug 17.

a Department of Rheumatology , Kawasaki Medical School , Kurashiki , Japan.

Scrub typhus is a mite-borne infectious disease caused by Orientia tsutsugamushi, which is found mainly in East and Southeast Asia and in Australia. The disease presents with a variety of non-specific symptoms, including fever, headache, cough, myalgia, and rash. Delay in starting appropriate antimicrobial therapy may lead to serious complications and even death. Read More

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http://dx.doi.org/10.1080/13497413.2018.1481581DOI Listing
June 2018
1 Read

Clinical and Epidemiological Patterns of Scrub Typhus, an Emerging Disease in Bhutan.

Trop Med Infect Dis 2019 Mar 29;4(2). Epub 2019 Mar 29.

School of Veterinary Science, Massey University, Palmerston North 4442, New Zealand.

Scrub typhus (ST) is a vector-borne rickettsial infection causing acute febrile illness. The re-emergence of ST in the Asia-Pacific region represents a serious public health threat. ST was first detected in Bhutan in 2008. Read More

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http://dx.doi.org/10.3390/tropicalmed4020056DOI Listing
March 2019
3 Reads

Case Report: Scrub Typhus and Q Fever Coinfection.

Am J Trop Med Hyg 2019 Mar 25. Epub 2019 Mar 25.

Department of Internal Medicine, College of Medicine, Chosun University, Gwangju, South Korea.

A 56-year-old female goat herder had scrub typhus that persisted after receiving doxycycline for 5 days. Her symptoms continued, prompting us to perform further examinations that revealed coinfection of Q fever and scrub typhus via molecular and serological testing. We also isolated using BALB/c mice and L929 cells. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0092DOI Listing
March 2019
3 Reads

Recent Increase of Human Granulocytic Anaplasmosis and Co-Infection with Scrub Typhus or Korean Hemorrhagic Fever with Renal Syndrome in Korea.

J Korean Med Sci 2019 Mar 12;34(11):e87. Epub 2019 Mar 12.

Department of Internal Medicine, Chonbuk National University Hospital, Chonbuk National University Medical School, Jeonju, Korea.

We report 17 patients with human granulocytic anaplasmosis between January 2015 and September 2018 at two tertiary university hospitals in Korea. Monthly incidence peaked in May and June. Among these patients, we identified three who were co-infected with scrub typhus, and one patient with hemorrhagic fever with renal syndrome. Read More

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http://dx.doi.org/10.3346/jkms.2019.34.e87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6427050PMC
March 2019
4 Reads

Indicators of severe prognosis of scrub typhus: prognostic factors of scrub typhus severity.

BMC Infect Dis 2019 Mar 25;19(1):283. Epub 2019 Mar 25.

Department of Internal Medicine, Chosun University College of Medicine, 588 Seosuk-dong, Dong-gu, Gwangju, 501-717, Republic of Korea.

Background: Scrub typhus is an acute disease, characterized by symptoms of fever, which occurs due to infection by Orientia tsutsugamushi. In most cases, patients recover from the disease with appropriate treatment, but serious and fatal complications may occur. The present study examined laboratory findings and tumor necrosis factor-alpha (TNF-α) levels of scrub typhus patients to identify the prognostic predictors of disease severity. Read More

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http://dx.doi.org/10.1186/s12879-019-3903-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434784PMC
March 2019
4 Reads

Evaluation of Th1 and Th2 immune response in clinical and sub-clinical scrub typhus infection.

Hum Immunol 2019 Mar 20. Epub 2019 Mar 20.

Medical Entomology, Arbovirology and Rickettsial Disease Division, Indian Council of Medical Research- Regional Medical Research Centre, N.E. Region, Post box no. 105, Dibrugarh-786001, Assam, India. Electronic address:

Scrub typhus (ST), caused by a gram negative intracellular bacteria- Orientia tsutsugamushi, is one among the leading causes of febrile illness across Southeast Asia, including India. Clinical presentation can vary from asymptomatic to severely fatal. Th1-cell mediated immunity has been suggested to play an important role against ST infection in animal models. Read More

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http://dx.doi.org/10.1016/j.humimm.2019.03.013DOI Listing
March 2019
2 Reads

Guillain-Barre syndrome: a rare complication of leptospirosis and scrub typhus co-infection.

Trop Doct 2019 Mar 21:49475519836038. Epub 2019 Mar 21.

3 Consultant, Department of Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India.

Guillain-Barré syndrome (GBS) is a potentially life-threatening immune-mediated acute inflammatory polyneuropathy associated with several antecedent infections. We report a 20-year-old man with GBS associated with concurrent leptospirosis and scrub typhus infection. GBS was confirmed with clinical examination and nerve conduction studies. Read More

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http://dx.doi.org/10.1177/0049475519836038DOI Listing
March 2019
1 Read

Clinical Manifestations and Molecular Diagnosis of Scrub Typhus and Murine Typhus, Vietnam, 2015-2017.

Emerg Infect Dis 2019 Apr;25(4)

Rickettsioses are endemic to Vietnam; however, only a limited number of clinical studies have been performed on these vectorborne bacteria. We conducted a prospective hospital-based study at 2 national referral hospitals in Hanoi to describe the clinical characteristics of scrub typhus and murine typhus in northern Vietnam and to assess the diagnostic applicability of quantitative real-time PCR assays to diagnose rickettsial diseases. We enrolled 302 patients with acute undifferentiated fever and clinically suspected rickettsiosis during March 2015-March 2017. Read More

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http://dx.doi.org/10.3201/eid2504.180691DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433017PMC
April 2019
3 Reads

A novel diagnostic algorithm equipped on an automated hematology analyzer to differentiate between common causes of febrile illness in Southeast Asia.

PLoS Negl Trop Dis 2019 03 14;13(3):e0007183. Epub 2019 Mar 14.

Department of Internal Medicine, Radboud Center for Infectious Diseases, Radboud university medical center, Nijmegen, The Netherlands.

Background: Distinguishing arboviral infections from bacterial causes of febrile illness is of great importance for clinical management. The Infection Manager System (IMS) is a novel diagnostic algorithm equipped on a Sysmex hematology analyzer that evaluates the host response using novel techniques that quantify cellular activation and cell membrane composition. The aim of this study was to train and validate the IMS to differentiate between arboviral and common bacterial infections in Southeast Asia and compare its performance against C-reactive protein (CRP) and procalcitonin (PCT). Read More

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http://dx.doi.org/10.1371/journal.pntd.0007183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435198PMC
March 2019
5 Reads

Detection of human parvovirus 4 DNA in the patients with acute encephalitis syndrome during seasonal outbreaks of the disease in Gorakhpur, India.

Emerg Microbes Infect 2019 ;8(1):130-138

a National Institute of Virology, Microbial Containment Complex , Pune , India.

Seasonal outbreaks of acute encephalitis syndrome (AES) at Gorakhpur, India have been recognized since 2006. So far, the causative agent has not been identified. Use of next generation sequencing identified human parvovirus 4 (HPARV4) sequences in a CSF/plasma pool. Read More

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https://www.tandfonline.com/doi/full/10.1080/22221751.2018.1
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http://dx.doi.org/10.1080/22221751.2018.1563455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455185PMC
January 2019
7 Reads

Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity.

J Pediatric Infect Dis Soc 2019 Mar 13. Epub 2019 Mar 13.

Department of Medicine, Swiss Tropical and Public Health Institute and Faculty of Medicine, University of Basel, Switzerland.

Background: Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics.

Methods: We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diagnosis was confirmed by the detection of (1) O. Read More

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http://dx.doi.org/10.1093/jpids/piz014DOI Listing
March 2019
2 Reads

Murine typhus in Mexico City: report of an imported case.

Rev Inst Med Trop Sao Paulo 2019 Mar 11;61:e16. Epub 2019 Mar 11.

Universidad Nacional Autónoma de México, Facultad de Medicina, Centro de Medicina Tropical, Unidad de Investigación en Medicina Experimental, Ciudad de México, México.

Murine typhus is endemic in several countries. We herein report an imported case of murine typhus caused by Rickettsia typhi in Mexico City. This is the first report of a case after almost 20 years since the last report. Read More

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http://dx.doi.org/10.1590/S1678-9946201961016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413773PMC
March 2019
6 Reads
0.907 Impact Factor

Metagenomic Approach to Characterizing Disease Epidemiology in a Disease-Endemic Environment in Northern Thailand.

Front Microbiol 2019 26;10:319. Epub 2019 Feb 26.

Department of Entomology, US Army Medical Directorate of the Armed Forces Research Institute of Medical Sciences (USAMD-AFRIMS), Bangkok, Thailand.

In this study, we used a metagenomic approach to analyze bacterial communities from diverse populations (humans, animals, and vectors) to investigate the role of these microorganisms as causative agents of disease in human and animal populations. Wild rodents and ectoparasites were collected from 2014 to 2018 in Nan province, Thailand where scrub typhus is highly endemic. Samples from undifferentiated febrile illness (UFI) patients were obtained from a local hospital. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6399164PMC
February 2019
2 Reads

Determination of Optimal Diagnostic Cut-Offs for the Naval Medical Research Centre Scrub Typhus IgM ELISA in Chiang Rai, Thailand.

Am J Trop Med Hyg 2019 Mar 11. Epub 2019 Mar 11.

Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Churchill Hospital, Oxford, United Kingdom.

In this diagnostic accuracy study, we evaluated data from 135 febrile patients from Chiang Rai, to determine the optimal optical density (OD) cutoffs for an in-house scrub typhus IgM ELISA. Receiver operating characteristic curves were generated using a panel of reference assays, including an IgM immunofluorescence assay (IFA), PCR, in vitro isolation, presence of an eschar, or a combination of these. Altogether, 33 patients (24. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0675DOI Listing
March 2019
5 Reads
2.699 Impact Factor

Rickettsiae Within the Fleas of Feral Cats in Galveston, Texas.

Vector Borne Zoonotic Dis 2019 Mar 5. Epub 2019 Mar 5.

3 The Animal Clinic, Galveston, Texas.

Murine typhus is a flea-borne typhus group rickettsiosis caused by Rickettsia typhi. Once a prevalent disease in the United States, the use of dichlorodiphenyltrichloroethane in the 1940s broke the classic rat-rat flea cycle of transmission, and the remaining endemic foci are now believed to be associated with opossums and the cat flea (Ctenocephalides felis). In Galveston, Texas murine typhus has re-emerged as a cause of febrile illness, and 7% of fleas collected from opossums are infected with R. Read More

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https://www.liebertpub.com/doi/10.1089/vbz.2018.2402
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http://dx.doi.org/10.1089/vbz.2018.2402DOI Listing
March 2019
4 Reads

Scrub Typhus in Continental Chile, 2016-2018.

Emerg Infect Dis 2019 Jun 17;25(6). Epub 2019 Jun 17.

Endemic scrub typhus was recently detected on Chiloé Island in southern Chile. We report a series of cases, acquired over a wide geographical range in continental Chile during 2016-2018, demonstrating that this emerging rickettsial infection is also found on the mainland of South America. Read More

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http://dx.doi.org/10.3201/eid2506.181860DOI Listing
June 2019
3 Reads

Case 4: Acute Onset of Fever, Jaundice, and Hyponatremia in a 17-year-old Boy.

Pediatr Rev 2019 Mar 1;40(3):148-150. Epub 2019 Mar 1.

Department of Pediatric Infectious Disease, Dell Children's Medical Center of Central Texas, Austin, TX.

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http://dx.doi.org/10.1542/pir.2017-0127DOI Listing
March 2019
2 Reads

Hospitalisations and outpatient visits for undifferentiated fever attributable to scrub typhus in rural South India: Retrospective cohort and nested case-control study.

PLoS Negl Trop Dis 2019 02 25;13(2):e0007160. Epub 2019 Feb 25.

Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background: The burden of scrub typhus in endemic areas is poorly understood. This study aimed at estimating the proportion of hospitalisations and outpatient visits for undifferentiated fever in the community that may be attributable to scrub typhus.

Methodology And Principal Findings: The study was a retrospective cohort with a nested case-control study conducted in the South Indian state of Tamil Nadu. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405239PMC
February 2019
4 Reads

Dissemination of in a Case of Scrub Typhus.

Am J Trop Med Hyg 2019 Feb;100(2):235-236

Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Republic of Korea.

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http://dx.doi.org/10.4269/ajtmh.18-0689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367607PMC
February 2019
1 Read

[Evaluation of the effectiveness of the serological methods for the identification of antibodies in patients with tissue ricketsiosis on the territories of a different risk of Rickettsia sibirica infection.]

Klin Lab Diagn 2018;63(12):777-782

Omsk Research Institute of natural focal Infections, 644080, Omsk, Russia.

Cases of tick-borne rickettsiosis in Siberia and the Far East are associated with R. sibirica, the causative agent of Siberian tick typhus (STT). In connection with a sharp reduction in the nomenclature of diagnostic products and an increase in the spectrum of species of founding rickettsiae on the territory of Russia, new approaches to the laboratory verification of diagnoses are needed. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-777-782DOI Listing
January 2018
5 Reads

Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction.

BMC Infect Dis 2019 Feb 19;19(1):174. Epub 2019 Feb 19.

Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, the Republic of Korea.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is emerging in Asian 3 countries, China, Japan and Korea, which are scrub typhus endemic areas, and its incidence is increasing. As the two infections overlap epidemiologically and clinically and the accessibility or sensitivity of diagnostic tests is limited, early clinical prediction may be useful for diagnostic and therapeutic purposes.

Methods: Patients aged ≥16 years who were clinically suspected and laboratory-confirmed to be infected with Orientia tsutsugamushi or the SFTS virus in South Korea were enrolled. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3773-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6381645PMC
February 2019
10 Reads

High Morbidity Due to Murine Typhus Upsurge in Urban Neighborhoods in Central Israel.

Am J Trop Med Hyg 2019 Apr;100(4):952-956

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The incidence of murine typhus in Israel has decreased substantially since 1950 to a low of 0.04/100,000 population in 2010. We present the experience of a single university medical center in central Israel. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447134PMC
April 2019
6 Reads

Human Tick-Borne Diseases in Australia.

Front Cell Infect Microbiol 2019 28;9. Epub 2019 Jan 28.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

There are 17 human-biting ticks known in Australia. The bites of , and can cause paralysis, inflammation, and severe local and systemic reactions in humans, respectively. Six ticks, including , and may transmit , or subsp. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360175PMC
January 2019
5 Reads

Scrub Typhus and Abnormal Electrocardiography.

Am J Trop Med Hyg 2019 Feb;100(2):399-404

Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea.

This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age- and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367634PMC
February 2019
1 Read

Development and evaluation of latex agglutination test coating with recombinant antigen, LipL32 for serodiagnosis of human leptospirosis.

J Genet Eng Biotechnol 2018 Dec 3;16(2):441-446. Epub 2018 Dec 3.

Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand.

Leptospirosis is a widespread zoonotic disease caused by . Symptoms of disease range from mild symptoms to serious complications including, jaundice, pulmonary hemorrhage, renal and hepatic failure, which may prove fatal. Clinical presentations of this disease are similar with other febrile illness. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353862PMC
December 2018
2 Reads

Epidemiology, Risk Factors and Seasonal Variation of Scrub Typhus Fever in Central Nepal.

Trop Med Infect Dis 2019 Feb 2;4(1). Epub 2019 Feb 2.

Department of Microbiology, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu 44600 Nepal.

a zoonotic bacterial infection common in the region known as the tsutsugamushi triangle. This study aims to determine the seroprevalence, seasonal variation, and risk factors of scrub typhus among the acute febrile illness patients attending different hospitals of central Nepal. Blood samples were collected from hospitalized patients of acute febrile illness suspected of scrub typhus infection attending different hospitals of central Nepal from April 2017 to March 2018. Read More

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http://www.mdpi.com/2414-6366/4/1/27
Publisher Site
http://dx.doi.org/10.3390/tropicalmed4010027DOI Listing
February 2019
8 Reads

The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: A review of the evidence.

PLoS Negl Trop Dis 2019 02 4;13(2):e0007158. Epub 2019 Feb 4.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Scrub typhus is a neglected tropical disease that causes acute febrile illness. Diagnosis is made based upon serology, or detection of the causative agent-Orientia tsutsugamushi-using PCR or in vitro isolation. The enzyme-linked immunosorbent assay (ELISA) is an objective and reproducible means of detecting IgM or IgG antibodies. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6382213PMC
February 2019
2 Reads

The Rickettsioses: A Practical Update.

Authors:
Lucas S Blanton

Infect Dis Clin North Am 2019 Mar;33(1):213-229

Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA. Electronic address:

Rickettsia are small, obligately intracellular, gram-negative bacilli. They are distributed among a variety of hematophagous arthropod vectors and cause illness throughout the world. Rickettsioses present as an acute undifferentiated febrile illness and are often accompanied by headache, myalgias, and malaise. Read More

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http://dx.doi.org/10.1016/j.idc.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364315PMC
March 2019
5 Reads

Diagnosis of Murine Typhus by Serology in Peninsular Malaysia: A Case Report Where Rickettsial Illnesses, Leptospirosis and Dengue Co-Circulate.

Trop Med Infect Dis 2019 Jan 31;4(1). Epub 2019 Jan 31.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. Read More

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http://dx.doi.org/10.3390/tropicalmed4010023DOI Listing
January 2019
3 Reads

Scrub typhus strikes back: Are we ready?

Med J Armed Forces India 2019 Jan 10;75(1):8-17. Epub 2019 Jan 10.

Professor & Head, Department of Community Medicine, Armed Forces Medical College, Pune 411040, India.

Scrub typhus has struck back, albeit with renewed vigour, impacting areas with previously known endemicity as also impressing newer expanses. It is not surprising, therefore, that Scrub typhus has emerged as a leading cause of public health concern globally as well as in India, but are we ready to take on the challenge? Over the last decade, there has been a global increase in the number of outbreaks of Scrub typhus, be it the military occupied areas or the civil population at large. The innumerable outbreaks of Scrub typhus, although disconcerting, have nonetheless contributed phenomenally towards better understanding of the dynamics of scrub typhus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03771237193001
Publisher Site
http://dx.doi.org/10.1016/j.mjafi.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349656PMC
January 2019
8 Reads

Seroprevalence of Dengue Virus and Rickettsial Infections in Cambodian Children.

Am J Trop Med Hyg 2019 Mar;100(3):635-638

Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

Scrub typhus (ST, ), murine typhus (MT, ), and dengue virus (DENV) are important causes of childhood morbidity in Cambodia. This prospective, cross-sectional seroprevalence study determined the proportion of Cambodian children infected by these pathogens and the ages at which initial infection is likely to occur. A total of 993 patient serum samples were tested for MT- and ST-specific IgG, and 837 samples tested for DENV-specific IgG. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0865
Publisher Site
http://dx.doi.org/10.4269/ajtmh.18-0865DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402902PMC
March 2019
10 Reads
2.699 Impact Factor

Persistent febrile illnesses in Nepal: A systematic review.

Indian J Med Res 2018 Oct;148(4):385-395

Epidemiology and Control of Neglected Tropical Diseases Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background & Objectives: Although febrile illnesses are a frequent cause of consultation and hospitalization in low- and middle-income countries (LMICs), research has mainly focused on acute febrile illnesses (AFIs). In contrast, there are limited data on the causes of persistent febrile illnesses (PFIs) in LMIC. Lack of clarity on the differential diagnosis of PFIs in the rural tropics leads to the absence of diagnostic guidance tools. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_505_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362719PMC
October 2018
2 Reads
1.661 Impact Factor

Distribution of Orientia tsutsugamushi in rodents and mites collected from Central India.

Environ Monit Assess 2019 Jan 18;191(2):82. Epub 2019 Jan 18.

ICAR-National Research Centre on Meat, Hyderabad, 500092, India.

Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracytosolic bacterium transmitted among humans and small mammals by some species of larval trombiculid mites (chiggers). It has been recognized as a pathogen of major public health concern in the Asia-Pacific region. As disease is considered as a neglected, there exists a gap in our knowledge of the disease with regard to the sporadic epidemiologic data in endemic areas. Read More

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http://dx.doi.org/10.1007/s10661-019-7208-7DOI Listing
January 2019
5 Reads

Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a four year AES surveillance study of Japanese encephalitis in selected states of India.

Int J Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

CDC India, New Delhi, India.

Background: Acute encephalitis syndrome (AES) surveillance in India has indicated that Japanese encephalitis virus (JEV) accounts for 5-35% of AES cases annually; the etiology remains unknown in the remaining cases. We implemented comprehensive AES surveillance to identify other etiological agents of AES, with emphasis on dengue virus.

Methods: Serum and cerebrospinal fluid (CSF) specimens were collected from patients enrolled prospectively in AES surveillance from 2014-2017 at selected sites of three high burden states of India. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.008DOI Listing
January 2019
5 Reads
2.330 Impact Factor

Scrub typhus risk in travelers to southern Chile.

Travel Med Infect Dis 2019 Jan 9. Epub 2019 Jan 9.

Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2019.01.004DOI Listing
January 2019
6 Reads

Etiologies of Acute Undifferentiated Febrile Illness in Bangkok, Thailand.

Am J Trop Med Hyg 2019 Mar;100(3):622-629

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Acute undifferentiated febrile illness (AUFI) has been a diagnostic dilemma in the tropics. Without accurate point-of-care tests, information on local pathogens and clinical parameters is essential for presumptive diagnosis. A prospective hospital-based study was conducted at the Bangkok Hospital for Tropical Diseases from 2013 to 2015 to determine common etiologies of AUFI. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402898PMC
March 2019
8 Reads

The impact of infectious disease in war time: a look back at WW1.

Authors:
Hugh Pennington

Future Microbiol 2019 Feb 10;14:165-168. Epub 2019 Jan 10.

Emeritus Professor of Bacteriology, University of Aberdeen, 13 Carlton Place, Aberdeen AB15 4BR, UK.

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http://dx.doi.org/10.2217/fmb-2018-0323DOI Listing
February 2019
5 Reads

Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children.

J Adv Res 2019 Jan 18;15:111-116. Epub 2018 Jul 18.

Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon and life-threatening disorder that may rarely complicate the clinical course of Orientia tsutsugamushi disease (scrub typhus). Here, we describe the clinical features, laboratory parameters, management, and outcome of 16 children with scrub typhus-associated HLH. All patients satisfied the HLH-2004 diagnostic criteria. Read More

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http://dx.doi.org/10.1016/j.jare.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300568PMC
January 2019
2 Reads

Concomitant malaria and murine typhus infection with pulmonary involvement.

BMJ Case Rep 2018 Dec 9;11(1). Epub 2018 Dec 9.

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

We report a case of and murine typhus coinfection in a 30-year-old woman who presented with intermittent, high-grade fever. Her peripheral blood smear showed ring-form trophozoites of , with an initial murine typhus serological test being negative. Although infection was successfully treated, she still had intermittent, high-grade fever, developed dyspnoea and bilateral interstitial pneumonitis shown in the chest X-ray. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226139
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http://dx.doi.org/10.1136/bcr-2018-226139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301767PMC
December 2018
12 Reads

Acute severe monarthritis: a rare manifestation of scrub typhus.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Paediatrics, Kasturba Medical College, Manipal, Karnataka, India.

Scrub typhus caused by is an important cause for fever of unknown origin in endemic areas including India. The vasculitis associated with the disease leads to a variety of clinical manifestations. However, the joint involvement is quite rare and not reported in children. Read More

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http://dx.doi.org/10.1136/bcr-2018-227002DOI Listing
December 2018
6 Reads

Murine Typhus: A Life-Threatening Presentation of a Case in Galveston, Texas.

Am J Case Rep 2018 Dec 18;19:1503-1506. Epub 2018 Dec 18.

Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, TX, USA.

BACKGROUND Murine typhus is a rare bacterial infection caused by Rickettsia typhi, which is transmitted from rodents to humans through the infected Xenopsylla cheopis flea. The disease presentation is often non-specific, leading to unnecessary tests, and a delay in diagnosis and treatment. CASE REPORT A report is presented of a 22-year-old, previously healthy man, who presented with several symptoms and signs that increased in severity, requiring admission to the medical intensive care unit (MICU). Read More

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http://dx.doi.org/10.12659/AJCR.909369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320554PMC
December 2018
3 Reads

The Obligate Intracellular Bacterium Targets NLRC5 To Modulate the Major Histocompatibility Complex Class I Pathway.

Infect Immun 2019 Mar 21;87(3). Epub 2019 Feb 21.

Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA

is an obligate intracellular bacterium that infects mononuclear and endothelial cells to cause the emerging global health threat scrub typhus. The ability of to survive in monocytes facilitates bacterial dissemination to endothelial cells, which can subsequently lead to several potentially fatal sequelae. As a strict intracellular pathogen that lives in the cytoplasm of host cells, has evolved to counter adaptive immunity. Read More

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http://dx.doi.org/10.1128/IAI.00876-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386551PMC
March 2019
5 Reads

[A Rickettsia case caused by Rickettsia conorii].

Mikrobiyol Bul 2018 Oct;52(4):431-438

Ministry of Health, General Directorate of Public Health, Microbiology Reference Laboratory, Ankara, Turkey.

Rickettsia species are gram-negative intracellular, small pleomorphic coccobacilli in the Rickettsiaceae family. This genus is serologically and genotypically divided into four groups as spotted fever group, typhus group, Rickettsia belli and Rickettsia canadensis. Rickettsia conorii (R. Read More

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http://dx.doi.org/10.5578/mb.67139DOI Listing
October 2018
2 Reads

High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia.

Vector Borne Zoonotic Dis 2018 Dec 12. Epub 2018 Dec 12.

2 Department of Parasitology and Faculty of Medicine, University of Malaya , Kuala Lumpur, Malaysia .

Rickettsioses of the typhus group (TG) and spotted fever group (SFG) are emerging bacterial infections worldwide, especially in the tropics. Only a few studies on these pathogens and their respective clinical diseases have been conducted in Malaysia. Here, we performed a seroprevalence study among 544 healthy, afebrile indigenous people (Orang Asli) from peninsular Malaysia for TG and SFG rickettsioses in nine rural and peri-urban settlements. Read More

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http://dx.doi.org/10.1089/vbz.2018.2391DOI Listing
December 2018