6,430 results match your criteria Typhus


Dual RNA-seq of Orientia tsutsugamushi informs on host-pathogen interactions for this neglected intracellular human pathogen.

Nat Commun 2020 Jul 3;11(1):3363. Epub 2020 Jul 3.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Studying emerging or neglected pathogens is often challenging due to insufficient information and absence of genetic tools. Dual RNA-seq provides insights into host-pathogen interactions, and is particularly informative for intracellular organisms. Here we apply dual RNA-seq to Orientia tsutsugamushi (Ot), an obligate intracellular bacterium that causes the vector-borne human disease scrub typhus. Read More

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http://dx.doi.org/10.1038/s41467-020-17094-8DOI Listing

Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.

Open Forum Infect Dis 2020 Jun 26;7(6):ofaa194. Epub 2020 May 26.

Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Background: Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately identify bacterial and viral ARI in cohorts of European and African descent. We determined classifier performance in a South Asian cohort. Read More

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http://dx.doi.org/10.1093/ofid/ofaa194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314590PMC

Surveillance of Chigger Mite Vectors for Tsutsugamushi Disease in the Hwaseong Area, Gyeonggi-do, Republic of Korea, 2015.

Korean J Parasitol 2020 Jun 26;58(3):301-308. Epub 2020 Jun 26.

Department of Tropical Medicine, Inha University College of Medicine, Incheon 22212, Korea.

Owing to global climate change, the global resurgence of vector-borne infectious diseases and their potential to inflict widespread casualties among human populations has emerged as a pivotal burden on public health systems. Tsutsugamushi disease (scrub typhus) in the Republic of Korea is steadily increasing and was designated as a legal communicable disease in 1994. The disease is a mite-borne acute febrile disease most commonly contracted from October to December. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.3.301DOI Listing

Chronic encephalopathy and locked-in state due to scrub typhus related CNS vasculitis.

J Neuroimmunol 2020 Jun 24;346:577303. Epub 2020 Jun 24.

Microbiology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Background: Scrub Typhus, prevalent in Asia-Pacific region, often has neurological manifestations in the setting of acute febrile illness, as acute encephalitis syndrome.

Case Report: A 20-year-old female, from western Rajasthan, India presented with calf pain followed by nausea, vomiting, dizziness, and sequentially progressive weakness of limbs, anarthria and loss of bladder control over 10 days. MRI Brain showed T2-weighted and FLAIR hyperintense lesions in corpus callosum, subcortical and periventricular white matter, basal ganglia, thalamus, brainstem and cerebellum producing starry sky appearance with diffusion restriction. Read More

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http://dx.doi.org/10.1016/j.jneuroim.2020.577303DOI Listing

Spotted Fever Group Rickettsiae among Children with Acute Febrile Illness, in Gorakhpur, India.

J Trop Pediatr 2020 Jun 30. Epub 2020 Jun 30.

Indian Council of Medical Research-National Institute of Epidemiology, Chennai, Tamil Nadu, India.

Seasonal outbreaks of acute encephalitis syndrome have been occurring in Gorakhpur division in the Indian state of Uttar Pradesh during monsoon and post-monsoon months. Orientia tsutsugamushi was identified as the major aetiology of these outbreaks. Orientia tsutsugamushi was also identified as one of the important aetiology of febrile illness among children attending peripheral health facilities. Read More

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http://dx.doi.org/10.1093/tropej/fmaa031DOI Listing

Opsoclonus in Scrub Typhus.

Ann Indian Acad Neurol 2020 May-Jun;23(3):367. Epub 2020 Jun 10.

Department of Neurology, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.

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http://dx.doi.org/10.4103/aian.AIAN_230_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313607PMC

Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas.

Nine criteria regarding the infectious agent, mode of transmission, portal of entry, route of spread, target organs, target cells, pathologic lesions, incubation period, and modifiable spectrum of disease and outcomes appropriate to the intended experimental purpose are described. To provide context for each criterion, mouse models of two vector-borne zoonotic infectious diseases, scrub typhus and dengue, are summarized. Application of the criteria indicates that intravenous inoculation of into inbred mice is the best current model for life-threatening scrub typhus, and intradermal inoculation accurately models sublethal human scrub typhus, whereas the immunocompromised mouse models of dengue provide disease outcomes most closely associated with human dengue. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0955DOI Listing

Case Report: Renal Failure due to Focal Segmental Glomerulosclerosis in a Patient with Murine Typhus.

Am J Trop Med Hyg 2020 Jun 22. Epub 2020 Jun 22.

Division of General Medicine, Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas.

Murine typhus is a flea-borne rickettsiosis caused by . When severe, endothelial dysfunction can lead to acute kidney injury secondary to prerenal azotemia or acute tubular necrosis. Here, we describe an unusual cause of kidney injury during the course of murine typhus-focal segmental glomerulosclerosis. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0116DOI Listing

Prediction Rule for Scrub Typhus Meningoencephalitis in Children: Emerging Disease in North India.

J Child Neurol 2020 Jun 25:883073820933148. Epub 2020 Jun 25.

Department of Pediatrics, King George's Medical University, Lucknow, Uttar Pradesh, India.

Objectives: To evaluate the proportion of scrub typhus meningoencephalitis among children with acute encephalitis syndrome and to outline its differentiating features. To develop a prediction rule for scrub typhus meningoencephalitis.

Methods: A prospective cohort study was conducted at a tertiary care public hospital in Northern India. Read More

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http://dx.doi.org/10.1177/0883073820933148DOI Listing

Rickettsioses as Major Etiologies of Unrecognized Acute Febrile Illness, Sabah, East Malaysia.

Emerg Infect Dis 2020 Jul;26(7)

Orientia tsutsugamushi, spotted fever group rickettsioses, and typhus group rickettsioses (TGR) are reemerging causes of acute febrile illness (AFI) in Southeast Asia. To further delineate extent, we enrolled patients >4 weeks of age with nonmalarial AFI in Sabah, Malaysia, during 2013-2015. We confirmed rickettsioses (past or acute, IgG titer >160) in 126/354 (36%) patients. Read More

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http://dx.doi.org/10.3201/eid2607.191722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7323546PMC

Clinical Profile of Scrub Typhus in Newborns.

Indian Pediatr 2020 Jun;57(6):579

Department of Neonatology, Institute of Child Health and Hospital for Children, Madras Medical College, Chennai, India.

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A chromosome-level assembly of the cat flea genome uncovers rampant gene duplication and genome size plasticity.

BMC Biol 2020 Jun 19;18(1):70. Epub 2020 Jun 19.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.

Background: Fleas (Insecta: Siphonaptera) are small flightless parasites of birds and mammals; their blood-feeding can transmit many serious pathogens (i.e., the etiological agents of bubonic plague, endemic and murine typhus). Read More

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http://dx.doi.org/10.1186/s12915-020-00802-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305587PMC

Successful Detection of Unrecognized in Pregnancy Using Cell-Free Next-Generation Sequencing.

Case Rep Obstet Gynecol 2020 26;2020:6767351. Epub 2020 May 26.

Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX, USA.

Flea-borne (murine) typhus is caused by . Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic. Read More

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http://dx.doi.org/10.1155/2020/6767351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271245PMC

Risk1, a Phosphatidylinositol 3-Kinase Effector, Promotes Rickettsia typhi Intracellular Survival.

mBio 2020 Jun 16;11(3). Epub 2020 Jun 16.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA

To establish a habitable intracellular niche, various pathogenic bacteria secrete effectors that target intracellular trafficking and modulate phosphoinositide (PI) metabolism. Murine typhus, caused by the obligate intracellular bacterium , remains a severe disease in humans. However, the mechanisms by which effector molecules contribute to internalization by induced phagocytosis and subsequent phagosomal escape into the cytosol to facilitate the intracellular growth of the bacteria remain ill-defined. Read More

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http://dx.doi.org/10.1128/mBio.00820-20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298712PMC

Aetiology and short-term outcome of acute respiratory distress syndrome: a real-world experience from a medical intensive care unit in southern India.

J R Coll Physicians Edinb 2020 03;50(1):12-18

Department of Medicine, JIPMER, Puducherry.

Background: Acute respiratory distress syndrome (ARDS) is a highly fatal syndrome especially in resource constrained settings. In this study we prospectively studied the aetiology of ARDS and its short-term outcome.

Methods: Consecutive adults with suspected ARDS were screened. Read More

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http://dx.doi.org/10.4997/JRCPE.2020.104DOI Listing

Scrub Typhus with Respiratory Symptoms.

Intern Med 2020 Jun 15. Epub 2020 Jun 15.

National Center for Global Health and Medicine, Japan.

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http://dx.doi.org/10.2169/internalmedicine.4268-19DOI Listing

Contagious Diseases and its Consequences in the Late Qajar Period Mashhad (1892-1921).

Arch Iran Med 2020 Jun 1;23(6):414-421. Epub 2020 Jun 1.

Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

One of the historical periods of Iran that can be studied for contagious diseases and how they spread, is the late Qajar period. The city of Mashhad, after Tehran and Tabriz, had a special place among Russian and English governments in the Qajar period as one of the significant religious, political and economic centers in Iran due to Imam Reza's holy shrine, a large population and great geographical scale. The central governments' incompetence in preventing the outbreak of contagious diseases and lack of essential amenities, caused many lives to be lost all over Iran and especially Mashhad during the Qajar period. Read More

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http://dx.doi.org/10.34172/aim.2020.37DOI Listing

central nervous system infection.

IDCases 2020 29;21:e00852. Epub 2020 May 29.

UIW School of Osteopathic Medicine, Laredo Medical Center, 1700 E. Saunders St. - P.O. Box 2068, Laredo, TX 78044-2068, USA.

A 39 year-old male was residing along the south coast of Texas, the USA, presented with fever, myalgias, headaches, and weight loss for ten days. Symptoms and manifestations progressed to include nuchal rigidity, photophobia, hyponatremia, thrombocytopenia, and transaminitis despite the intravenous administration of ceftriaxone and azithromycin. A lumbar puncture performed in the Emergency Department yielded pleocytosis and glucose cerebrospinal fluid/serum ratio of 0. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265057PMC

Stye Can Lie! - A Rare Presentation of Scrub Typhus Eschar.

Indian J Pediatr 2020 Jun 3. Epub 2020 Jun 3.

Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Andhra Pradesh, 522 503, India.

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http://dx.doi.org/10.1007/s12098-020-03303-1DOI Listing
June 2020
0.919 Impact Factor

Hepatic and Renal Profile of Scrub Typhus Patients at a Tertiary Care Center in India.

Cureus 2020 May 2;12(5):e7925. Epub 2020 May 2.

Internal Medicine, Government Medical College and Hospital, Chandigarh, IND.

Introduction Scrub typhus is a resurging zoonotic infection prevalent in South Asia with many recent outbreaks in India. It can mimic other tropical infections and the disease spectrum ranges from subclinical illness to life-threatening disease with multiorgan dysfunction. This study was conducted to study the pattern of hepatic and renal injury. Read More

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http://dx.doi.org/10.7759/cureus.7925DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7265748PMC

Optimization and evaluation of a multiplex quantitative PCR assay for detection of nucleic acids in human blood from patients with spotted fever rickettsiosis, typhus rickettsiosis, scrub typhus, monocytic ehrlichiosis, and granulocytic anaplasmosis.

J Clin Microbiol 2020 Jun 3. Epub 2020 Jun 3.

Division of Medical Microbiology, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Spotted fever group (SFGR) and typhus group (TGR) rickettsioses, scrub typhus (caused by , [OT]), ehrlichiosis, and anaplasmosis often present as undifferentiated fever but are not treated by agents (penicillins and cephalosporins) typically used for acute febrile illness. Inability to diagnose these infections when the patient is acutely ill leads to excess morbidity and mortality. Failure to confirm these infections retrospectively if a convalescent blood sample is not obtained also impairs epidemiologic and clinical research. Read More

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http://dx.doi.org/10.1128/JCM.01802-19DOI Listing

Establishment of Recombinase Polymerase Amplification assay for rapid and sensitive detection of Orientia tsutsugamushi in Southeast Asia.

Acta Trop 2020 May 31;210:105541. Epub 2020 May 31.

Department of Genomics and Cytogenetics, Institute of Biomedicine and Pharmacy (IBP), Vietnam Military Medical University, Vietnam; Department of Medical Microbiology, The 103 Military Hospital, Vietnam Medical University, Vietnam. Electronic address:

Scrub typhus, caused by Orientia tsutsugamushi, is a common fever in parts of Southern and Southeast Asia. As delayed diagnosis of scrub typhus leads to inappropriate treatment and high mortality rates, of up to 70%, sensitive and rapid detection of O. tsutsugamushi is required for timely and appropriate treatment. Read More

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http://dx.doi.org/10.1016/j.actatropica.2020.105541DOI Listing

Erythematous Patch in Tsutsugamushi Disease: An Atypical Form of Eschar.

Infect Chemother 2020 05 29. Epub 2020 May 29.

Department of Microbiology, Inha University, Incheon, Korea.

Tsutsugamushi disease is caused by the bacterium, and transmitted by chigger mites. In addition to the typical dark eschar, various forms of the eschar, including papules and vesicles, develop at chigger bite sites. Macular lesions were reported only in a human inoculation study; the inoculation lesions relapsed as erythematous macules or erythema-based papules concomitant with fever relapse. Read More

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Seroprevalence & seroincidence of infection in Gorakhpur, Uttar Pradesh, India: A community-based serosurvey during lean (April-May) & epidemic (October-November) periods for acute encephalitis syndrome.

Indian J Med Res 2020 04;151(4):350-360

ICMR-National AIDS Research Institute, Pune, Maharashtra, India.

Background & Objectives: In India, acute encephalitis syndrome (AES) cases are frequently reported from Gorakhpur district in Uttar Pradesh. Scrub typhus is one of the predominant aetiological agents for these cases. In order to delineate the extent of the background of scrub typhus seroprevalence and the associated risk factors at community level, serosurveys during both lean and epidemic periods (phase 1 and phase 2, respectively) of AES outbreaks were conducted in this region. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_1330_18DOI Listing

Serum procalcitonin as a biomarker of bloodstream infection & focal bacterial infection in febrile patients.

Indian J Med Res 2020 04;151(4):342-349

Department of Community Medicine, Sri Venkateswara Institute of Medical Sciences, Tirupati, Andhra Pradesh, India.

Background & Objectives: Bacteraemia is a serious form of infection in patients presenting with fever, thus, there is a necessity for a biomarker for rapid diagnosis of bacteraemia in such patients to make better therapeutic decisions. This study was conducted to measure the serum procalcitonin (PCT) levels at the time of initial presentation as a biomarker for identifying bacteraemia and as a predictor of mortality in patients admitted with acute fever.

Methods: Four hundred and eighty patients, who presented with acute fever requiring admission to a tertiary care teaching hospital in south India, were prospectively studied. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_324_18DOI Listing

Risk Factors for Scrub Typhus, Murine Typhus, and Spotted Fever Seropositivity in Urban Areas, Rural Plains, and Peri-Forest Hill Villages in South India: A Cross-Sectional Study.

Am J Trop Med Hyg 2020 May 26. Epub 2020 May 26.

Department of Clinical Microbiology, Christian Medical College, Vellore, India.

Scrub typhus and spotted fever group rickettsioses are thought to be common causes of febrile illness in India, whereas murine typhus is rarely tested for. This cross-sectional study explored the risk factors associated with scrub typhus, tick-borne spotted fever, and murine typhus seropositivity in three different geographical settings, urban, rural, and hill villages in Tamil Nadu, South India. We enrolled 1,353 participants living in 48 clusters. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0642DOI Listing

Underdiagnoses of Rickettsia in patients hospitalized with acute fever in Indonesia: observational study results.

BMC Infect Dis 2020 May 24;20(1):364. Epub 2020 May 24.

Hasan Sadikin Hospital - Faculty of Medicine Universitas Padjadjaran, Bandung, Indonesia.

Background: Reports of human rickettsial infection in Indonesia are limited. This study sought to characterize the epidemiology of human rickettsioses amongst patients hospitalized with fever at 8 tertiary hospitals in Indonesia.

Methods: Acute and convalescent blood from 975 hospitalized non-dengue patients was tested for Rickettsia IgM and IgG by ELISA. Read More

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http://dx.doi.org/10.1186/s12879-020-05057-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245627PMC

Epidemiologic Changes of Scrub Typhus in China, 1952-2016.

Emerg Infect Dis 2020 Jun;26(6):1091-1101

Scrub typhus, a miteborne rickettsiosis, has emerged in many areas globally. We analyzed the incidence and spatial-temporal distribution of scrub typhus in China during 1952-1989 and 2006-2016 using national disease surveillance data. A total of 133,623 cases and 174 deaths were recorded. Read More

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http://dx.doi.org/10.3201/eid2606.191168DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7258452PMC

Assessment of two immunoassays for detection of IgM antibodies to scrub typhus using a serum panel.

Indian J Med Microbiol 2019 Oct-Dec;37(4):584-586

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Laboratory tests are necessary for diagnosis of scrub typhus (ST) especially in the absence of the distinctive eschar. Performance of an ELISA and ICT (immunochromatography) to detect IgM antibodies to scrub typhus was assessed using a panel of 346 sera chosen from healthy individuals, those with scrub typhus and scrub-typhus like illness. A sensitivity of 98. Read More

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http://dx.doi.org/10.4103/ijmm.IJMM_20_130DOI Listing

Molecular detection of Candidatus Rickettsia asembonensis in fleas collected from pets and domestic animals in Puducherry, India.

Med Vet Entomol 2020 May 20. Epub 2020 May 20.

Division of Vector Biology and Control, ICMR-Vector Control Research Centre (ICMR-VCRC), Indira Nagar, Puducherry, India.

Rickettsia are obligate intracellular pathogens transmitted by arthropod vectors. The re-emergence of several rickettsioses imposes severe global health burden. In addition to the well-established rickettsial pathogens, newer rickettsial species and their pathogenic potentials are being uncovered. Read More

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http://dx.doi.org/10.1111/mve.12449DOI Listing

[THE PSYCHOLOGICAL IMPACT OF COVID-19 ON MENTAL HEALTH - LITERATURE REVIEW].

Harefuah 2020 May;159(5):320-325

Geha Mental Health Center, Clalit Health Services, and Sackler Faculty of Medicine, Tel Aviv University, National Council for Suicide Prevention.

Introduction: The spread of epidemics resulting in many deaths has been known since the dawn of civilization, for example, the typhus and smallpox epidemics and the plague. Early in the previous century there was an outbreak of the Spanish Flue and towards the end of the 60's, the AIDS epidemic (HIV). Since the start of the current century, several epidemics broke out and spread to various places around the world, for instance, SARS (Severe Acute Respiratory Syndrome), the Avian Influenza and the Swine Influenza. Read More

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Relative Abundance of a Vector of Scrub Typhus, Leptotrombidium sialkotense, in Southern Yunnan Province, China.

Korean J Parasitol 2020 Apr 30;58(2):153-159. Epub 2020 Apr 30.

Vector Laboratory, Institute of Pathogens and Vectors, Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Dali University, Dali, Yunnan Province 671000, China.

The chigger mite Leptotrombidium sialkotense is one of the 6 main vectors of scrub typhus in China. Before present study, L. sialkotense was found in some parts of Hunan province, China with a narrow geographical distribution. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.2.153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7231826PMC

Cerebellitis as a rare manifestation of scrub typhus fever.

BMJ Case Rep 2020 May 14;13(5). Epub 2020 May 14.

Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.

Scrub typhus is a mite-borne rickettsial disease caused by a gram-negative coccobacilli transmitted through the bite of chigger mite. Scrub typhus has diverse clinical manifestations, often presenting either as a simple febrile illness or as a complicated multi-organ dysfunction. Neurological complications in scrub typhus are diverse but their exact incidence is unknown. Read More

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http://dx.doi.org/10.1136/bcr-2019-233993DOI Listing

Plagues, pandemics and epidemics in Irish history prior to COVID-19 (coronavirus): what can we learn?

Authors:
B D Kelly

Ir J Psychol Med 2020 Apr 15:1-6. Epub 2020 Apr 15.

Department of Psychiatry, Trinity College Dublin, Trinity Centre for Health Sciences, Tallaght University Hospital, Dublin 24, Ireland.

Objectives: This paper seeks to provide a brief overview of epidemics and pandemics in Irish history and to identify any lessons that might be useful in relation to psychiatry in the context of COVID-19.

Methods: A review of selected key reports, papers and publications related to epidemics and pandemics in Irish history was conducted.

Results: Viruses, epidemics and pandemics are recurring features of human history. Read More

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http://dx.doi.org/10.1017/ipm.2020.25DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225208PMC

Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus.

BMC Infect Dis 2020 May 12;20(1):334. Epub 2020 May 12.

Division of Infectious Diseases, Department of Internal Medicine, E-Da Hospital, I-Shou University, No.1, Yi-Da Road, Jiao-Su Village, Yan-Chao District, Kaohsiung City, 824, Taiwan.

Background: Although C-reactive protein (CRP) and procalcitonin (PCT) are widely used inflammatory markers for infectious diseases, their role and potential application for rickettsioses were rarely studied.

Methods: A retrospective chart review and serological study were conducted in patients with rickettsioses. The clinical presentations, characteristics, laboratory data, and treatment responses were recorded and their associations with CRP and PCT values were analyzed. Read More

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http://dx.doi.org/10.1186/s12879-020-05058-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7216490PMC

A deubiquitylase with an unusually high-affinity ubiquitin-binding domain from the scrub typhus pathogen Orientia tsutsugamushi.

Nat Commun 2020 May 11;11(1):2343. Epub 2020 May 11.

Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT, 06520, USA.

Ubiquitin mediated signaling contributes critically to host cell defenses during pathogen infection. Many pathogens manipulate the ubiquitin system to evade these defenses. Here we characterize a likely effector protein bearing a deubiquitylase (DUB) domain from the obligate intracellular bacterium Orientia tsutsugamushi, the causative agent of scrub typhus. Read More

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http://dx.doi.org/10.1038/s41467-020-15985-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7214410PMC

Circulation of Rickettsia species and rickettsial endosymbionts among small mammals and their ectoparasites in Eastern Slovakia.

Parasitol Res 2020 Jul 8;119(7):2047-2057. Epub 2020 May 8.

Institute of Zoology Slovak Academy of Sciences, Dúbravská cesta 9, 845 06, Bratislava, Slovak Republic.

Bacteria belonging to the genus Rickettsia are known as causative agents of vector-borne zoonotic diseases, such as spotted fevers, epidemic typhus and endemic typhus. Different species of ticks, mites and fleas could act as reservoirs and arthropod vectors of different pathogenic Rickettsia species. The aim of this work was to establish active surveillance of Rickettsia spp. Read More

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http://dx.doi.org/10.1007/s00436-020-06701-8DOI Listing

Scrub typhus as a rare cause of acute pyelonephritis: case report.

BMC Infect Dis 2020 May 6;20(1):322. Epub 2020 May 6.

Global Institute for Interdisciplinary Studies/Gandaki Medical College Teaching Hospital, Post Box: 24560, Sundhara, Kathmandu, Nepal.

Background: Scrub typhus can present with atypical signs and symptoms such as those of acute kidney injury, gastroenteritis, pneumonitis, and acute respiratory distress syndrome. Meningitis, encephalitis, and hepatic dysfunction have also been reported, particularly in severe cases with multisystem involvement. Scrub typhus has never been reported in the literature to cause urinary tract infections (UTIs) which includes cystitis and pyelonephritis. Read More

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http://dx.doi.org/10.1186/s12879-020-05050-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7201669PMC

Application of Extracorporeal Membrane Oxygenation in Patients with Scrub Typhus Complicated with Acute Respiratory Distress Syndrome.

Heart Surg Forum 2020 03 31;23(2):E183-E186. Epub 2020 Mar 31.

Department of Extracorporeal Membrane Oxygenation Laboratory, Zhongshan City People's Hospital, Zhongshan, China.

A 68-year-old woman was diagnosed with scrub typhus and acute pneumonia. Acute respiratory distress syndrome (ARDS) occurred on day 4 after admission and was treated with extracorporeal membrane oxygenation (ECMO). After 7 days of ECMO assistance, her respiratory condition gradually improved, and ECMO was removed. Read More

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http://dx.doi.org/10.1532/hsf.2827DOI Listing

Murine typhus. How does it affect us in the 21st century? The epidemiology of inpatients in Spain (1997-2015).

Int J Infect Dis 2020 Apr 27;96:165-171. Epub 2020 Apr 27.

Complejo Asistencial Universitario de Salamanca (CAUSA), Instituto de investigación biomédica de Salamanca (IBSAL), Centro de Investigación de Enfermedades Tropicales de la Universidad de Salamanca, (CIETUS), University of Salamanca, Paseo San Vicente 58-182, 37007, Salamanca, Spain. Electronic address:

Objective: The aim of this study was to analyze the epidemiological impact of murine typhus in patients who required hospitalization in the National Health System (SNS) in Spain between 1997 and 2015.

Background: Murine typhus (MT) is a zoonosis caused by Rickettsia typhi. MT is transmitted from rats, cats, dogs, and opossums to humans by their fleas. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.04.054DOI Listing

Evaluation of recombinant type-specific antigens of Orientia tsutsugamushi which were expressed by baculovirus-insect cell system as antigens for indirect immunofluorescent assay in the serological diagnosis of scrub typhus.

Jpn J Infect Dis 2020 Apr 30. Epub 2020 Apr 30.

Department of Virology I, National Institute of Infectious Diseases.

Scrub typhus is a mite-borne rickettsiosis caused by the intracellular bacterium Orientia tsutsugamushi (OTS), which is classified as a biosafety level-3 (BSL-3) pathogen. For serological tests of scrub typhus, mouse fibroblast cells infected with the five prevalent serotypes of OTS in Japan are generally used as antigens for indirect immunofluorescent assay (IFA). In this study, sf-9 insect cells infected with the recombinant type-specific antigens (rTSA)-expressing baculovirus were applied for IFA. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2019.334DOI Listing

Disease Ecology of Rickettsial Species: A Data Science Approach.

Trop Med Infect Dis 2020 Apr 27;5(2). Epub 2020 Apr 27.

The Office of Disease Prevention and Control 12, Songkhla Province (ODPC12), Department of Disease Control, Ministry of Public Health, Songkhla 90000, Thailand.

We present an approach to assess the disease ecology of rickettsial species by investigating open databases and by using data science methodologies. First, we explored the epidemiological trend and changes of human rickettsial disease epidemics over the years and compared this trend with knowledge on emerging rickettsial diseases given by published reviews. Second, we investigated the global diversity of rickettsial species recorded in humans, domestic animals and wild mammals, using the Enhanced Infectious Disease Database (EID2) and employing a network analysis approach to represent and quantify transmission ecology of rickettsial species among their carriers, arthropod vectors or mammal reservoirs and humans. Read More

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http://dx.doi.org/10.3390/tropicalmed5020064DOI Listing

Clinical Profile and Outcome of Adult Patients with Scrub Typhus in a Tertiary Care Centre of Eastern Nepal.

JNMA J Nepal Med Assoc 2020 Mar;58(223):165-169

Department of Biochemistry, Nobel Medical College Teaching Hospital, Biratnagar, Nepal.

Introduction: Scrub typhus is an under-diagnosed and undertreated zoonotic human infection. There are no data related to profile of adult patients in Nepal. We conducted this study to report socio-demographic, clinical profile and complications of scrub typhus in our scenario. Read More

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Pulmonary thromboembolism - A rare complication in a scrub typhus infection.

IDCases 2020 30;20:e00751. Epub 2020 Mar 30.

Department of Paediatrics, Midnapore Medical College and Hospital, Paschim Medinipur, West Bengal, India.

We describe a rare haematological complication of pulmonary thromboembolism in a scrub typhus infection. There are very few case reports on scrub typhus infection causing deep venous thrombosis. Vasculitis and perivasculitis with endothelial dysfunction could be considered as the main pathologic mechanism causing this complication. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7183153PMC

Rickettsial Diseases: Not Uncommon Causes of Acute Febrile Illness in India.

Trop Med Infect Dis 2020 Apr 15;5(2). Epub 2020 Apr 15.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Rickettsial diseases (RDs) are major under-diagnosed causes of arthropod borne acute febrile illness (AFI) presenting with a range of symptoms from mild self-limiting fever to fatal sepsis. The spotted fever group (SFG) and typhus group (TG) are major RDs, which are commonly caused by and , respectively. The limited availability and role of serological tests in the acute phase of illness warrants rapid reliable molecular methods for diagnosis and epidemiological studies. Read More

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http://dx.doi.org/10.3390/tropicalmed5020059DOI Listing

Rise in Murine Typhus in Galveston County, Texas, USA, 2018.

Emerg Infect Dis 2020 May;26(5):1044-1046

Murine typhus, an undifferentiated febrile illness caused by Rickettsia typhi, is increasing in prevalence and distribution throughout Texas. In 2018, a total of 40 cases of murine typhus were reported in Galveston County. This increase, unprecedented since the 1940s, highlights the importance of awareness by physicians and public health officials. Read More

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http://dx.doi.org/10.3201/eid2605.191505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7181902PMC

A case of Henoch-Schönlein purpura associated with scrub typhus.

BMC Infect Dis 2020 Apr 17;20(1):286. Epub 2020 Apr 17.

Division of Infectious Diseases, Department of Internal Medicine, Inha University College of Medicine, 7-206, Shinheung-Dong, Jung-Gu, Incheon, 22332, Republic of Korea.

Background: Henoch-Schönlein purpura (HSP) may be caused by several allergens. However, to date, HSP caused by Orientia tsutsugamushi has not been reported. Here, we report an unusual rash with features of HSP caused by Orientia tsutsugamushi. Read More

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http://dx.doi.org/10.1186/s12879-020-05001-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165380PMC

The estimated burden of scrub typhus in Thailand from national surveillance data (2003-2018).

PLoS Negl Trop Dis 2020 04 14;14(4):e0008233. Epub 2020 Apr 14.

CNRS ISEM-CIRAD ASTRE, Faculty of Veterinary Technology, Kasetsart University, Bangkok, Thailand.

Background: Scrub typhus is a major cause of acute febrile illness in the tropics and is endemic over large areas of the Asia Pacific region. The national and global burden of scrub typhus remains unclear due to limited data and difficulties surrounding diagnosis.

Methodology/principal Findings: Scrub typhus reporting data from 2003-2018 were collected from the Thai national disease surveillance system. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7182275PMC

Clinical profile and outcome of patients with Crimean Congo haemorrhagic fever: a hospital based observational study from Rajasthan, India.

Trans R Soc Trop Med Hyg 2020 Apr 14. Epub 2020 Apr 14.

Department of Internal Medicine, All India Institute of Medical Sciences, Jodhpur, Basni Industrial estate, Jodhpur, 342005, India.

Background: Crimean Congo haemorrhagic fever (CCHF) is an emerging zoonotic infection with high mortality. Nosocomial spread is described secondary to body fluid contact.

Methods: Patients meeting the case definition for viral haemorrhagic fever (VHF) from August to November 2019 were tested for CCHF after ruling out dengue, malaria, scrub typhus and leptospirosis in a tertiary teaching hospital in western Rajasthan, India. Read More

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http://dx.doi.org/10.1093/trstmh/traa014DOI Listing
April 2020
1.931 Impact Factor