6,159 results match your criteria Typhus


[Evaluation of the effectiveness of the serological methods for the identification of antibodies in patients with tissue ricketsiosis on the territories of a different risk of Rickettsia sibirica infection.]

Klin Lab Diagn 2018 ;63(12):777-782

Omsk Research Institute of natural focal Infections, 644080, Omsk, Russia.

Cases of tick-borne rickettsiosis in Siberia and the Far East are associated with R. sibirica, the causative agent of Siberian tick typhus (STT). In connection with a sharp reduction in the nomenclature of diagnostic products and an increase in the spectrum of species of founding rickettsiae on the territory of Russia, new approaches to the laboratory verification of diagnoses are needed. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-12-777-782DOI Listing
January 2018
1 Read

Severe fever with thrombocytopenia syndrome: comparison with scrub typhus and clinical diagnostic prediction.

BMC Infect Dis 2019 Feb 19;19(1):174. Epub 2019 Feb 19.

Department of Internal Medicine, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, the Republic of Korea.

Background: Severe fever with thrombocytopenia syndrome (SFTS) is emerging in Asian 3 countries, China, Japan and Korea, which are scrub typhus endemic areas, and its incidence is increasing. As the two infections overlap epidemiologically and clinically and the accessibility or sensitivity of diagnostic tests is limited, early clinical prediction may be useful for diagnostic and therapeutic purposes.

Methods: Patients aged ≥16 years who were clinically suspected and laboratory-confirmed to be infected with Orientia tsutsugamushi or the SFTS virus in South Korea were enrolled. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-019-3773-1DOI Listing
February 2019
1 Read

High Morbidity Due to Murine Typhus Upsurge in Urban Neighborhoods in Central Israel.

Am J Trop Med Hyg 2019 Feb 11. Epub 2019 Feb 11.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

The incidence of murine typhus in Israel has decreased substantially since 1950 to a low of 0.04/100,000 population in 2010. We present the experience of a single university medical center in central Israel. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0076DOI Listing
February 2019
1 Read

Human Tick-Borne Diseases in Australia.

Front Cell Infect Microbiol 2019 28;9. Epub 2019 Jan 28.

Neuroinflammation Group, Faculty of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia.

There are 17 human-biting ticks known in Australia. The bites of , and can cause paralysis, inflammation, and severe local and systemic reactions in humans, respectively. Six ticks, including , and may transmit , or subsp. Read More

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http://dx.doi.org/10.3389/fcimb.2019.00003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360175PMC
January 2019
1 Read

Scrub Typhus and Abnormal Electrocardiography.

Am J Trop Med Hyg 2019 Feb;100(2):399-404

Department of Internal Medicine, School of Medicine, Chosun University, Gwangju, Republic of Korea.

This study compared the frequency of abnormal electrocardiogram (ECG) types between scrub typhus patient group and age- and gender-matched health checkup group and their associations with disease severity in scrub typhus patient. Demographic characteristics and ECG and laboratory findings of patients with scrub typhus admitted to Chosun University Hospital, and normal subjects visiting the hospital for health checkup from January 2008 to December 2012 were retrospectively studied. Electrocardiogram abnormalities at admission were observed in 72 of 165 (43. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367634PMC
February 2019

Development and evaluation of latex agglutination test coating with recombinant antigen, LipL32 for serodiagnosis of human leptospirosis.

J Genet Eng Biotechnol 2018 Dec 3;16(2):441-446. Epub 2018 Dec 3.

Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok 65000, Thailand.

Leptospirosis is a widespread zoonotic disease caused by . Symptoms of disease range from mild symptoms to serious complications including, jaundice, pulmonary hemorrhage, renal and hepatic failure, which may prove fatal. Clinical presentations of this disease are similar with other febrile illness. Read More

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http://dx.doi.org/10.1016/j.jgeb.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353862PMC
December 2018
2 Reads

Epidemiology, Risk Factors and Seasonal Variation of Scrub Typhus Fever in Central Nepal.

Trop Med Infect Dis 2019 Feb 2;4(1). Epub 2019 Feb 2.

Department of Microbiology, Maharajgunj Medical Campus, Institute of Medicine, Kathmandu 44600 Nepal.

a zoonotic bacterial infection common in the region known as the tsutsugamushi triangle. This study aims to determine the seroprevalence, seasonal variation, and risk factors of scrub typhus among the acute febrile illness patients attending different hospitals of central Nepal. Blood samples were collected from hospitalized patients of acute febrile illness suspected of scrub typhus infection attending different hospitals of central Nepal from April 2017 to March 2018. Read More

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http://www.mdpi.com/2414-6366/4/1/27
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http://dx.doi.org/10.3390/tropicalmed4010027DOI Listing
February 2019
3 Reads

The validity of diagnostic cut-offs for commercial and in-house scrub typhus IgM and IgG ELISAs: A review of the evidence.

PLoS Negl Trop Dis 2019 Feb 4;13(2):e0007158. Epub 2019 Feb 4.

Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Scrub typhus is a neglected tropical disease that causes acute febrile illness. Diagnosis is made based upon serology, or detection of the causative agent-Orientia tsutsugamushi-using PCR or in vitro isolation. The enzyme-linked immunosorbent assay (ELISA) is an objective and reproducible means of detecting IgM or IgG antibodies. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007158DOI Listing
February 2019
1 Read

The Rickettsioses: A Practical Update.

Authors:
Lucas S Blanton

Infect Dis Clin North Am 2019 Mar;33(1):213-229

Department of Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0435, USA. Electronic address:

Rickettsia are small, obligately intracellular, gram-negative bacilli. They are distributed among a variety of hematophagous arthropod vectors and cause illness throughout the world. Rickettsioses present as an acute undifferentiated febrile illness and are often accompanied by headache, myalgias, and malaise. Read More

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http://dx.doi.org/10.1016/j.idc.2018.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364315PMC
March 2019
1 Read

Diagnosis of Murine Typhus by Serology in Peninsular Malaysia: A Case Report Where Rickettsial Illnesses, Leptospirosis and Dengue Co-Circulate.

Trop Med Infect Dis 2019 Jan 31;4(1). Epub 2019 Jan 31.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok 10400, Thailand.

Murine typhus is a rarely diagnosed cause of acute febrile illness in Malaysia, and its true disease burden is unknown. We report a case of an acute murine typhus infection in a patient living in a small city in Peninsular Malaysia, presenting with fever, rash, and headache. Unresponsive to the initial empirical treatment for leptospirosis, he showed a rapid response to doxycycline when murine typhus was diagnosed later. Read More

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http://dx.doi.org/10.3390/tropicalmed4010023DOI Listing
January 2019
1 Read

Scrub typhus strikes back: Are we ready?

Med J Armed Forces India 2019 Jan 10;75(1):8-17. Epub 2019 Jan 10.

Professor & Head, Department of Community Medicine, Armed Forces Medical College, Pune 411040, India.

Scrub typhus has struck back, albeit with renewed vigour, impacting areas with previously known endemicity as also impressing newer expanses. It is not surprising, therefore, that Scrub typhus has emerged as a leading cause of public health concern globally as well as in India, but are we ready to take on the challenge? Over the last decade, there has been a global increase in the number of outbreaks of Scrub typhus, be it the military occupied areas or the civil population at large. The innumerable outbreaks of Scrub typhus, although disconcerting, have nonetheless contributed phenomenally towards better understanding of the dynamics of scrub typhus. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03771237193001
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http://dx.doi.org/10.1016/j.mjafi.2018.12.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349656PMC
January 2019
2 Reads

Seroprevalence of Dengue Virus and Rickettsial Infections in Cambodian Children.

Am J Trop Med Hyg 2019 Jan 21. Epub 2019 Jan 21.

Nuffield Department of Medicine, Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

Scrub typhus (ST, ), murine typhus (MT, ), and dengue virus (DENV) are important causes of childhood morbidity in Cambodia. This prospective, cross-sectional, seroprevalence study determined the proportion of Cambodian children infected by these pathogens and the ages at which initial infection is likely to occur. A total of 993 patient serum samples were tested for MT- and ST-specific IgG, and 837 samples tested for DENV-specific IgG. Read More

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http://www.ajtmh.org/content/journals/10.4269/ajtmh.18-0865
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http://dx.doi.org/10.4269/ajtmh.18-0865DOI Listing
January 2019
5 Reads
2.699 Impact Factor

Persistent febrile illnesses in Nepal: A systematic review.

Indian J Med Res 2018 Oct;148(4):385-395

Epidemiology and Control of Neglected Tropical Diseases Unit, Institute of Tropical Medicine, Antwerp, Belgium.

Background & Objectives: Although febrile illnesses are a frequent cause of consultation and hospitalization in low- and middle-income countries (LMICs), research has mainly focused on acute febrile illnesses (AFIs). In contrast, there are limited data on the causes of persistent febrile illnesses (PFIs) in LMIC. Lack of clarity on the differential diagnosis of PFIs in the rural tropics leads to the absence of diagnostic guidance tools. Read More

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http://dx.doi.org/10.4103/ijmr.IJMR_505_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362719PMC
October 2018
1 Read
1.661 Impact Factor

Distribution of Orientia tsutsugamushi in rodents and mites collected from Central India.

Environ Monit Assess 2019 Jan 18;191(2):82. Epub 2019 Jan 18.

ICAR-National Research Centre on Meat, Hyderabad, 500092, India.

Orientia tsutsugamushi, the causative agent of scrub typhus, is an obligate intracytosolic bacterium transmitted among humans and small mammals by some species of larval trombiculid mites (chiggers). It has been recognized as a pathogen of major public health concern in the Asia-Pacific region. As disease is considered as a neglected, there exists a gap in our knowledge of the disease with regard to the sporadic epidemiologic data in endemic areas. Read More

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http://dx.doi.org/10.1007/s10661-019-7208-7DOI Listing
January 2019
1 Read

Dengue virus is an under-recognised causative agent of acute encephalitis syndrome (AES): Results from a four year AES surveillance study of Japanese encephalitis in selected states of India.

Int J Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

CDC India, New Delhi, India.

Background: Acute encephalitis syndrome (AES) surveillance in India has indicated that Japanese encephalitis virus (JEV) accounts for 5-35% of AES cases annually; the etiology remains unknown in the remaining cases. We implemented comprehensive AES surveillance to identify other etiological agents of AES, with emphasis on dengue virus.

Methods: Serum and cerebrospinal fluid (CSF) specimens were collected from patients enrolled prospectively in AES surveillance from 2014-2017 at selected sites of three high burden states of India. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.008DOI Listing
January 2019
2 Reads
2.330 Impact Factor

Scrub typhus risk in travelers to southern Chile.

Travel Med Infect Dis 2019 Jan 9. Epub 2019 Jan 9.

Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2019.01.004DOI Listing
January 2019
2 Reads

Etiologies of Acute Undifferentiated Febrile Illness in Bangkok, Thailand.

Am J Trop Med Hyg 2019 Jan 7. Epub 2019 Jan 7.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Acute undifferentiated febrile illness (AUFI) has been a diagnostic dilemma in the tropics. Without accurate point-of-care tests, information on local pathogens and clinical parameters is essential for presumptive diagnosis. A prospective hospital-based study was conducted at the Bangkok Hospital for Tropical Diseases from 2013 to 2015 to determine common etiologies of AUFI. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0407DOI Listing
January 2019
4 Reads

The impact of infectious disease in war time: a look back at WW1.

Authors:
Hugh Pennington

Future Microbiol 2019 Jan 10. Epub 2019 Jan 10.

Emeritus Professor of Bacteriology, University of Aberdeen, 13 Carlton Place, Aberdeen AB15 4BR, UK.

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http://dx.doi.org/10.2217/fmb-2018-0323DOI Listing
January 2019
1 Read

Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children.

J Adv Res 2019 Jan 18;15:111-116. Epub 2018 Jul 18.

Department of Pediatrics, First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.

Hemophagocytic lymphohistiocytosis (HLH) is an uncommon and life-threatening disorder that may rarely complicate the clinical course of Orientia tsutsugamushi disease (scrub typhus). Here, we describe the clinical features, laboratory parameters, management, and outcome of 16 children with scrub typhus-associated HLH. All patients satisfied the HLH-2004 diagnostic criteria. Read More

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http://dx.doi.org/10.1016/j.jare.2018.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300568PMC
January 2019
1 Read

Concomitant malaria and murine typhus infection with pulmonary involvement.

BMJ Case Rep 2018 Dec 9;11(1). Epub 2018 Dec 9.

Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

We report a case of and murine typhus coinfection in a 30-year-old woman who presented with intermittent, high-grade fever. Her peripheral blood smear showed ring-form trophozoites of , with an initial murine typhus serological test being negative. Although infection was successfully treated, she still had intermittent, high-grade fever, developed dyspnoea and bilateral interstitial pneumonitis shown in the chest X-ray. Read More

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http://www.bmj.com/lookup/doi/10.1136/bcr-2018-226139
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http://dx.doi.org/10.1136/bcr-2018-226139DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6301767PMC
December 2018
6 Reads

Acute severe monarthritis: a rare manifestation of scrub typhus.

BMJ Case Rep 2018 Dec 3;11(1). Epub 2018 Dec 3.

Paediatrics, Kasturba Medical College, Manipal, Karnataka, India.

Scrub typhus caused by is an important cause for fever of unknown origin in endemic areas including India. The vasculitis associated with the disease leads to a variety of clinical manifestations. However, the joint involvement is quite rare and not reported in children. Read More

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http://dx.doi.org/10.1136/bcr-2018-227002DOI Listing
December 2018
5 Reads

Murine Typhus: A Life-Threatening Presentation of a Case in Galveston, Texas.

Am J Case Rep 2018 Dec 18;19:1503-1506. Epub 2018 Dec 18.

Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, TX, USA.

BACKGROUND Murine typhus is a rare bacterial infection caused by Rickettsia typhi, which is transmitted from rodents to humans through the infected Xenopsylla cheopis flea. The disease presentation is often non-specific, leading to unnecessary tests, and a delay in diagnosis and treatment. CASE REPORT A report is presented of a 22-year-old, previously healthy man, who presented with several symptoms and signs that increased in severity, requiring admission to the medical intensive care unit (MICU). Read More

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http://dx.doi.org/10.12659/AJCR.909369DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320554PMC
December 2018
1 Read

The obligate intracellular bacterium targets NLRC5 to modulate the MHC class-I pathway.

Infect Immun 2018 Dec 17. Epub 2018 Dec 17.

Department of Microbiology and Immunology, Virginia Commonwealth University Medical Center, School of Medicine, Richmond, Virginia, USA

is an obligate intracellular bacterium that infects mononuclear and endothelial cells to cause the emerging global health threat, scrub typhus. The ability of to survive in monocytes facilitates bacterial dissemination to endothelial cells, which can subsequently lead to several potentially fatal sequelae. As a strict intracellular pathogen that lives in the cytoplasm of host cells, has evolved to counter adaptive immunity. Read More

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http://dx.doi.org/10.1128/IAI.00876-18DOI Listing
December 2018
2 Reads

[A Rickettsia case caused by Rickettsia conorii].

Mikrobiyol Bul 2018 Oct;52(4):431-438

Ministry of Health, General Directorate of Public Health, Microbiology Reference Laboratory, Ankara, Turkey.

Rickettsia species are gram-negative intracellular, small pleomorphic coccobacilli in the Rickettsiaceae family. This genus is serologically and genotypically divided into four groups as spotted fever group, typhus group, Rickettsia belli and Rickettsia canadensis. Rickettsia conorii (R. Read More

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http://dx.doi.org/10.5578/mb.67139DOI Listing
October 2018
1 Read

High Seroprevalence Against Typhus Group and Spotted Fever Group Rickettsiae in Rural Indigenous Populations of Peninsular Malaysia.

Vector Borne Zoonotic Dis 2018 Dec 12. Epub 2018 Dec 12.

2 Department of Parasitology and Faculty of Medicine, University of Malaya , Kuala Lumpur, Malaysia .

Rickettsioses of the typhus group (TG) and spotted fever group (SFG) are emerging bacterial infections worldwide, especially in the tropics. Only a few studies on these pathogens and their respective clinical diseases have been conducted in Malaysia. Here, we performed a seroprevalence study among 544 healthy, afebrile indigenous people (Orang Asli) from peninsular Malaysia for TG and SFG rickettsioses in nine rural and peri-urban settlements. Read More

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http://dx.doi.org/10.1089/vbz.2018.2391DOI Listing
December 2018

Rickettsioses: Cutaneous findings frequently lead to diagnosis - a review.

J Dtsch Dermatol Ges 2018 Dec;16(12):1459-1476

While epidemic typhus caused by Rickettsia prowazekii posed a significant threat in Europe before and throughout World War II due to its high mortality, the condition fortunately no longer plays a significant role. Nevertheless, rickettsioses, such as African tick bite fever, have been increasingly diagnosed in travelers returning from sub-Saharan Africa. Caused by Rickettsia africae, African tick bite fever presents with characteristic cutaneous findings such as eschar (tache noir) and a rash. Read More

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http://dx.doi.org/10.1111/ddg.13712DOI Listing
December 2018
3 Reads

Spatiotemporal patterns and risk factors for Scrub Typhus from 2007 to 2017 in southern China.

Clin Infect Dis 2018 Dec 10. Epub 2018 Dec 10.

State Key Laboratory of Resources and Environmental Information System, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing, China.

Background: Substantial outbreaks of scrub typhus coupled with the discovery of this vector-borne disease in new areas suggest that the disease remains remarkably neglected. The objectives of this study were to map the contemporary and potential transmission risk zones of the disease and provide novel insights into the health burden imposed by scrub typhus in southern China.

Methods: Based on the assembled data sets of annual scrub typhus cases and maps of environmental and socioeconomic correlates, a boosted regression tree modeling procedure was used to identify the environmental niche of scrub typhus and to predict the potential infection zones of the disease. Read More

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http://dx.doi.org/10.1093/cid/ciy1050DOI Listing
December 2018
3 Reads

Evaluation of Enzyme-Linked Immunosorbent Assay Using Recombinant 56-kDa Type-Specific Antigens Derived from Multiple Strains for Detection of Scrub Typhus Infection.

Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.

Center for Diagnostics and Vaccine Development, Centers for Disease Control, Ministry of Health and Welfare, Taipei, Republic of China.

Scrub typhus is caused by the intracellular bacterium . The 56-kDa type-specific antigen (TSA) displays a significant antigenic variation across different strains. To minimize the influence of the antigenic diversity of TSA on assay sensitivity, we developed a mixed-TSA enzyme-linked immunosorbent assay (mixed-TSA ELISA) using a mixture of recombinant TSAs of prototype (Karp, Gilliam, and Kato) and local (TW-1, TW-10, TW-19, and TW-22) strains as antigens to detect IgM and IgG antibodies against . Read More

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http://dx.doi.org/10.4269/ajtmh.18-0391DOI Listing
December 2018
3 Reads

Bacterial microbiome of the chigger mite Leptotrombidium imphalum varies by life stage and infection with the scrub typhus pathogen Orientia tsutsugamushi.

PLoS One 2018 6;13(12):e0208327. Epub 2018 Dec 6.

Department of Entomology and Plant Pathology, North Carolina State University, Raleigh, North Carolina, United States of America.

Scrub typhus is a mites-borne rickettsiosis caused by the obligate intracellular Gram-negative bacterium Orientia tsutsugamushi. The disease is potentially life threatening and is prevalent in tropical Asia, islands of the western Pacific Ocean and northern Australia where an estimated one million cases occur annually. Orientia tsutsugamushi is transmitted by the bite of larval mites in the genus Leptotrombidium. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208327PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6283546PMC
December 2018
2 Reads

Geometric morphometrics of the scutum for differentiation of trombiculid mites within the genus Walchia (Acariformes: Prostigmata: Trombiculidae), a probable vector of scrub typhus.

Ticks Tick Borne Dis 2019 02 16;10(2):495-503. Epub 2018 Nov 16.

Department of Medical Entomology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address:

The vectors of scrub typhus are the larval stage of trombiculid mites, termed "chiggers". These vectors are very small - the larvae are approximately 0.2 mm in size - and therefore their morphological identification is difficult. Read More

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http://dx.doi.org/10.1016/j.ttbdis.2018.11.013DOI Listing
February 2019
1 Read

Scrub typhus and depression: a nationwide cohort analysis.

J Transl Med 2018 Dec 3;16(1):333. Epub 2018 Dec 3.

Department of Medical Research, Tungs' Taichung Metroharbor Hospital, Taichung, Taiwan.

Background: Studies on the relationship between depression and scrub typhus are limited. We conducted a retrospective cohort study to investigate whether scrub typhus is a risk factor for depression.

Methods: Using Taiwan's National Health Insurance Research Database, this study investigated the incidence of depression, and its risk factors, in patients diagnosed with scrub typhus between 2000 and 2010. Read More

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https://translational-medicine.biomedcentral.com/articles/10
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http://dx.doi.org/10.1186/s12967-018-1699-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276137PMC
December 2018
9 Reads

Ultrastructural visualization of Orientia tsutsugamushi in biopsied eschars and monocytes from scrub typhus patients in South Korea.

Sci Rep 2018 Nov 26;8(1):17373. Epub 2018 Nov 26.

Drug & Disease Target Team, Korea Basic Science Institute, Cheongju, 28119, South Korea.

Scrub typhus, which is caused by Orientia tsutsugamushi, is a public health problem in the Asian-Pacific region and is the third most frequently reported infectious disease in South Korea. While ultrastructural studies have been performed on O. tsutsugamushi in murine fibroblasts, its variable locations in patients have hampered similar studies in humans. Read More

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http://dx.doi.org/10.1038/s41598-018-35775-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255831PMC
November 2018
2 Reads

Socio-demographic and Clinico-Epidemiological Study of Scrub Typhus in Two Tertiary Care Hospitals of Kolkata.

J Assoc Physicians India 2018 May;66(5):22-5

Department of Medicine, VIMS, Kolkata, West Bengal.

Background And Aims: Scrub typhus is the commonest of the rickettsial diseases in India and is difficult to diagnose. Untreated cases have fatality rates of 30-45%. Eschar is present in 7-97% cases. Read More

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May 2018
9 Reads

Factors for Severe Outcome in Scrub Typhus: A Hospital Based Study in Sub Himalayan Region.

J Assoc Physicians India 2018 May;66(5):36-8

Professor, Department of Microbiology, IGMC, Shimla, Himachal Pradesh.

Background: Scrub typhus is a re-emerging zoonotic rickettsial infection. Mortality is approximately 15% in some areas due to missed or delayed diagnosis. There had been only few studies on the markers for the severity of the disease, so this study has been planned to provide the knowledge regarding various aspects of scrub typhus in adult age group to detect early signs of severity . Read More

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May 2018
13 Reads

Risk Factors for Acquiring Scrub Typhus among Children in Deoria and Gorakhpur Districts, Uttar Pradesh, India, 2017.

Emerg Infect Dis 2018 Dec;24(12):2364-2367

Scrub typhus is associated with outbreaks of acute encephalitis syndrome in Uttar Pradesh, India. A case-control study indicated that children residing, playing, or visiting fields; living with firewood stored indoors; handling cattle fodder; and practicing open defecation were at increased risk for scrub typhus. Communication messages should focus on changing these behaviors. Read More

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http://dx.doi.org/10.3201/eid2412.180695DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256400PMC
December 2018
3 Reads
6.751 Impact Factor

Bayesian zero-inflated spatio-temporal modelling of scrub typhus data in Korea, 2010-2014.

Geospat Health 2018 11 9;13(2). Epub 2018 Nov 9.

Department of Applied Statistics, Hanyang University, Seoul.

Scrub typhus, a bacterial, febrile disease commonly occurring in the autumn, can easily be cured if diagnosed early. However, it can develop serious complications and even lead to death. For this reason, it is an important issue to find the risk factors and thus be able to prevent outbreaks. Read More

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https://geospatialhealth.net/index.php/gh/article/view/665
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http://dx.doi.org/10.4081/gh.2018.665DOI Listing
November 2018
14 Reads

Ocular manifestations of in South India.

Indian J Ophthalmol 2018 Dec;66(12):1840-1844

Resident, Aravind Eye Hospital and Postgraduate Institute of Ophthalmology, Salem, Tamil Nadu, India.

Purpose: Among the major groups of rickettsiosis, the commonly reported diseases in India are: (a) Typhus group induced-scrub typhus, murine flea-borne typhus; (b) Spotted fever group induced-Indian tick typhus; and (c) Q fever. Though many scrub typhus outbreaks have been reported from India, only one outbreak of spotted fever-serologically proven Indian tick typhus (Rickettsia conorii)-has been reported. We report for the first time ocular manifestations of serologically proven R. Read More

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http://dx.doi.org/10.4103/ijo.IJO_420_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256869PMC
December 2018
10 Reads

Genomes of trombidid mites reveal novel predicted allergens and laterally transferred genes associated with secondary metabolism.

Gigascience 2018 12 1;7(12). Epub 2018 Dec 1.

Institute of Infection & Global Health, University of Liverpool, L3 5RF, United Kingdom.

Background: Trombidid mites have a unique life cycle in which only the larval stage is ectoparasitic. In the superfamily Trombiculoidea ("chiggers"), the larvae feed preferentially on vertebrates, including humans. Species in the genus Leptotrombidium are vectors of a potentially fatal bacterial infection, scrub typhus, that affects 1 million people annually. Read More

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https://academic.oup.com/gigascience/advance-article/doi/10.
Publisher Site
http://dx.doi.org/10.1093/gigascience/giy127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275457PMC
December 2018
10 Reads

Use of eschar for the molecular diagnosis and genotypic characterisation of causing scrub typhus.

Indian J Med Microbiol 2018 Jul-Sep;36(3):422-425

Department of Paediatric Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Scrub typhus caused by Orientia tsutsugamushi presents as an acute febrile illness with a varied presentation from mild illness to fatal disease in the absence of appropriate antibiotic treatment. Performing polymerase chain reaction (PCR) on eschar sample acts a rapid diagnostic tool in the early stage of scrub typhus when blood is negative. A total of eight patients from whom both whole blood and eschar samples were collected and tested by nested PCR targeting 56 kDa trichostatin A (TSA) gene to detect O. Read More

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http://www.ijmm.org/text.asp?2018/36/3/422/245399
Publisher Site
http://dx.doi.org/10.4103/ijmm.IJMM_18_8DOI Listing
November 2018
9 Reads
1.037 Impact Factor

Survey and Phylogenetic Analysis of Rodents and Important Rodent-Borne Zoonotic Pathogens in Gedu, Bhutan.

Korean J Parasitol 2018 Oct 31;56(5):521-525. Epub 2018 Oct 31.

International Development Group, School of Veterinary Science, Massey University, Palmerston North, New Zealand.

Rodents are well-known reservoirs and vectors of many emerging and re-emerging infectious diseases, but little is known about their role in zoonotic disease transmission in Bhutan. In this study, a cross-sectional investigation of zoonotic disease pathogens in rodents was performed in Chukha district, Bhutan, where a high incidence of scrub typhus and cases of acute undifferentiated febrile illness had been reported in people during the preceding 4-6 months. Twelve rodents were trapped alive using wire-mesh traps. Read More

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http://parasitol.kr/journal/view.php?doi=10.3347/kjp.2018.56
Publisher Site
http://dx.doi.org/10.3347/kjp.2018.56.5.521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243181PMC
October 2018
14 Reads

Tick- and flea-borne rickettsioses in Tizi-Ouzou, Algeria: Implications for travel medicine.

Travel Med Infect Dis 2018 Nov - Dec;26:51-57. Epub 2018 Nov 9.

Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France. Electronic address:

Background: In Algeria, Mediterranean spotted fever (MSF), caused by Rickettsia conorii conorii and transmitted by Rhipicephalus sanguineus, is endemic. However, the documentation of cases is rare due to a lack of laboratory facilities. Our aim was to screen for rickettsioses in patients with fever, rash and a possible inoculation eschar. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14778939183040
Publisher Site
http://dx.doi.org/10.1016/j.tmaid.2018.11.005DOI Listing
January 2019
15 Reads

Critical Illness Scoring Systems: Sequential Organ Failure Assessment, Acute Physiology and Chronic Health Evaluation II, and Quick Sequential Organ Failure Assessment to Predict the Clinical Outcomes in Scrub Typhus Patients with Organ Dysfunctions.

Indian J Crit Care Med 2018 Oct;22(10):706-710

Department of Nephrology, PGIMER, Chandigarh, India.

Background And Aim: Scrub typhus (ST) is an acute infectious disease of variable severity caused by (formerly ) . The disease can be complicated by organ dysfunctions and the case fatality rate (CFR) is approximately 15%, which further rises with the development of severe complications. We studied the clinical features of the ST and the performance of critical illness scoring systems (CISSs) - Acute Physiology and Chronic Health Evaluation (APACHE) II, sequential organ failure assessment (SOFA), and quick SOFA (qSOFA) in predicting the clinical outcomes in complicated ST (cST) patients admitted to the emergency department. Read More

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http://www.ijccm.org/text.asp?2018/22/10/706/243591
Publisher Site
http://dx.doi.org/10.4103/ijccm.IJCCM_254_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201639PMC
October 2018
21 Reads

A case report of scrub typhus complicated with myocarditis and rhabdomyolysis.

BMC Infect Dis 2018 Nov 7;18(1):551. Epub 2018 Nov 7.

Premedical Science, College of Medicine, Chosun University, Gwangju, Republic of Korea.

Background: Scrub typhus is a zoonotic disease caused by Orientia tsutsugamushi, a gram-negative intracellular bacterium. Myocarditis and rhabdomyolysis are rare complications of scrub typhus.

Case Presentation: We report a case of scrub typhus, which was simultaneously complicated with myocarditis and rhabdomyolysis. Read More

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http://dx.doi.org/10.1186/s12879-018-3458-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223005PMC
November 2018
2 Reads

Current challenges in the development of vaccines and drugs against emerging vector-borne diseases.

Authors:
Kwang-Sun Kim

Curr Med Chem 2018 Nov 5. Epub 2018 Nov 5.

Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 46241. Korea.

Vectors are living organisms that transmit infectious diseases from an infected animal to humans or another animal. Biological vectors such as mosquitoes, ticks, and sand flies carry pathogens that multiply within their bodies prior to delivery to a new host. The increased prevalence of vector-borne diseases (VBDs) such as Aedes-borne dengue, Chikungunya (CHIKV), Zika (ZIKV), malaria, tick-borne disease (TBD), and scrub typhus has a huge impact on the health of both humans and livestock worldwide. Read More

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http://www.eurekaselect.com/167030/article
Publisher Site
http://dx.doi.org/10.2174/0929867325666181105121146DOI Listing
November 2018
16 Reads

Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India.

Int J Infect Dis 2019 Feb 2;79:195-198. Epub 2018 Nov 2.

Indian Council of Medical Research, New Delhi, India.

Background: The aim of this study was to estimate the seroprevalence of spotted fever group (SFG) and typhus group (TG) rickettsiae among individuals with acute febrile illness (AFI) in the scrub typhus endemic district of Gorakhpur in India. This district is one of the worst affected by annual seasonal acute encephalitis syndrome (AES) outbreaks.

Methods: Antibodies against SFG and TG rickettsiae and the associated risk factors were determined in 294 individuals presenting with an AFI, encountered during a community-based survey conducted during the AES outbreak period October-November 2016. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.10.024DOI Listing
February 2019
2 Reads
2.330 Impact Factor

A surface antigen of activates human monocyte-derived dendritic cells via nuclear factor-kB & p38 mitogen-activated protein kinase pathways.

Indian J Med Res 2018 Aug;148(2):215-224

Institute of Medical Sciences, Tzu Chi University, Chia Yi, Taiwan.

Background & Objectives: Scrub typhus is a chigger-borne disease caused by Orientia tsutsugamushi. The immunological reactions to O. tsutsugamushi infection are not completely understood. Read More

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http://www.ijmr.org.in/text.asp?2018/148/2/215/243678
Publisher Site
http://dx.doi.org/10.4103/ijmr.IJMR_1417_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206779PMC
August 2018
4 Reads

Anti-aquaporin-4 Antibody Positive Optic Neuritis Following Scrub Typhus in an Elderly Female.

Neurologist 2018 Nov;23(6):183-184

Department of Neurology, St. Vincent Hospital, College of Medicine, The Catholic University of Korea, Gyeonggi-do, Korea.

Introduction: Aquaporin-4 antibody (AQP4-Ab) is specific for neuromyelitis optica spectrum disorder (NMOSD) and so is helpful to distinguish NMOSD from other autoimmune diseases. Several viral infections may play a role in the onset of NMOSD.

Case Report: We describe a case of a previous healthy 82-year-old woman who presented with acute visual loss occurring 3 weeks after scrub typhus. Read More

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http://dx.doi.org/10.1097/NRL.0000000000000196DOI Listing
November 2018
6 Reads

Hemophagocytic lymphohistiocytosis with neurological manifestations in an infant with scrub typhus: a rare fatal occurrence.

Trop Doct 2018 Oct 26:49475518804696. Epub 2018 Oct 26.

4 Director Professor and Head, Department of Pediatrics, Maulana Azad Medical College, New Delhi, India.

Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of unchecked activation of the immune system leading to phagocytosis of blood cells and proliferation of histiocytes in solid organs. HLH can be primary or secondary to infective, autoimmune and malignant conditions. Scrub typhus is an infective illness caused by Orientia tsutsugamushi, transmitted by mite. Read More

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http://dx.doi.org/10.1177/0049475518804696DOI Listing
October 2018
16 Reads

Ethnopharmacological study of Sephardic remedies in the 19th century: The "Livro de Milizinas".

J Ethnopharmacol 2019 Feb 21;230:20-73. Epub 2018 Oct 21.

Dpto. Ecología e Hidrología, Campus de Espinardo, Universidad de Murcia, 30100 Murcia, Spain. Electronic address:

Ethnopharmacological Relevance: The Sephardic or Judeo-Spanish communities kept a cultural heritage extremely relevant which is recognizable through the peculiar form of their language and practices. Medicine was one of the main professional activities among Jews of Spain before their expulsion in 1492. We expected to find ingredients and recipes in the Sephardic traditional medicine related to classical medicine and to modern ethnopharmacology of Spain, but also influenced by the host countries. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03788741183235
Publisher Site
http://dx.doi.org/10.1016/j.jep.2018.10.009DOI Listing
February 2019
9 Reads