13,118 results match your criteria Typhoid Fever


Identification of Genes Involved in Biogenesis of Outer Membrane Vesicles (OMVs) in Serovar Typhi.

Front Microbiol 2019 4;10:104. Epub 2019 Feb 4.

Laboratorio de Genética y Patogénesis Bacteriana, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile.

Outer membrane vesicles (OMVs) are nano-sized proteoliposomes discharged from the cell envelope of Gram-negative bacteria. OMVs normally contain toxins, enzymes and other factors, and are used as vehicles in a process that has been considered a generalized, evolutionarily conserved delivery system among bacteria. Furthermore, OMVs can be used in biotechnological applications that require delivery of biomolecules, such as vaccines, remarking the importance of their study. Read More

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http://dx.doi.org/10.3389/fmicb.2019.00104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369716PMC
February 2019

Integrating Typhoid Fever Within the Sustainable Development Goals: Pragmatism or Utopia?

Clin Infect Dis 2019 Feb;68(Supplement_1):S34-S41

Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada.

Several decades following the first estimates of the global burden of typhoidal salmonellosis (infections caused by Salmonella Typhi and Salmonella Paratyphi), this disorder remains a major cause of morbidity worldwide with an estimated 17 million cases annually. The risk factors for typhoid include poverty, poor living conditions with unsafe water and lack of adequate sanitation, and unsafe foods-all reasons for the disease burden being highest among such populations including urban slums. A recent review of typhoid trends globally and in specific countries suggests that the relative contributions of these risk factors to disease burden reduction as well as persistence have varied. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S34/532
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http://dx.doi.org/10.1093/cid/ciy957DOI Listing
February 2019
2 Reads

Introduction of Typhoid Conjugate Vaccines in Africa and Asia.

Clin Infect Dis 2019 Feb;68(Supplement_1):S27-S30

PATH, Seattle, Washington.

Typhoid fever continues to be a major public health concern, particularly in many low- and middle-income countries. The current threats of increasing antimicrobial resistance, urbanization, and climate change elevate the urgency for better prevention and control efforts for typhoid fever. In 2017, the results of ground-breaking research on typhoid conjugate vaccines (TCVs), the World Health Organization prequalification of a TCV, and global policy and financing decisions have set the stage for the introduction of TCVs into routine immunization programs in endemic countries. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S27/532
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http://dx.doi.org/10.1093/cid/ciy878DOI Listing
February 2019
2 Reads

Multidrug-resistant Nontyphoidal Salmonella Hotspots as Targets for Vaccine Use in Management of Infections in Endemic Settings.

Clin Infect Dis 2019 Feb;68(Supplement_1):S10-S15

Department of Medicine, University of Cambridge, United Kingdom.

Background: Salmonella infections cause a disproportionately high number of deaths in Africa, especially among poor urban populations. The increasing level of multidrug-resistant (MDR) infections is a major cause of concern in these settings where alternative effective treatment is unavailable. Other options for management of these infections must be sought. Read More

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http://dx.doi.org/10.1093/cid/ciy898DOI Listing
February 2019
1 Read

Overview of the Typhoid Conjugate Vaccine Pipeline: Current Status and Future Plans.

Clin Infect Dis 2019 Feb;68(Supplement_1):S22-S26

International Vaccine Institute, Seoul, Republic of Korea.

Typhoid fever remains a common and serious disease in populations that live in low- and middle-income countries. Treatment usually consists of antibiotics, but problems with drug-resistant strains have been increasing in endemic countries, making treatment prolonged and costly. Improved sanitation and food hygiene have been effective in controlling the disease in the industrialized world, but these steps are associated with socioeconomic progress that has been slow in most of the affected areas. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S22/532
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http://dx.doi.org/10.1093/cid/ciy884DOI Listing
February 2019
2 Reads

Revised Global Typhoid Vaccination Policy.

Clin Infect Dis 2019 Feb;68(Supplement_1):S31-S33

Department of Immunization, Vaccines and Biologicals, World Health Organization, Geneva, Switzerland.

Typhoid fever is a continuing public health problem in many low- and middle-income countries; however, routine vaccination as a recommended control strategy has not been implemented in the past in most countries. Greater understanding of the typhoid fever burden, the increasing threat of antimicrobial resistance, and licensure of a new generation of typhoid conjugate vaccines (TCVs) were instrumental in paving the way for the World Health Organization (WHO) to issue a revised global policy on typhoid vaccines in March 2018. The new policy follows evidence-based recommendations by the WHO Strategic Advisory Group of Experts on immunization for routine and catch-up vaccination with TCVs and highlights considerations for universal, risk-based, or phased vaccination strategies in different settings. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S31/532
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http://dx.doi.org/10.1093/cid/ciy927DOI Listing
February 2019
1 Read

Progress in Typhoid Fever Epidemiology.

Authors:
John A Crump

Clin Infect Dis 2019 Feb;68(Supplement_1):S4-S9

Centre for International Health, University of Otago, Dunedin, New Zealand.

Salmonella enterica subspecies enterica serovar Typhi (Salmonella Typhi) is the cause of typhoid fever and a human host-restricted organism. Our understanding of the global burden of typhoid fever has improved in recent decades, with both an increase in the number and geographic representation of high-quality typhoid fever incidence studies, and greater sophistication of modeling approaches. The 2017 World Health Organization Strategic Advisory Group of Experts on Immunization recommendation for the introduction of typhoid conjugate vaccines for infants and children aged >6 months in typhoid-endemic countries is likely to require further improvements in our understanding of typhoid burden at the global and national levels. Read More

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http://dx.doi.org/10.1093/cid/ciy846DOI Listing
February 2019

A Global Agenda for Typhoid Control-A Perspective from the Bill & Melinda Gates Foundation.

Clin Infect Dis 2019 Feb;68(Supplement_1):S42-S45

Enteric and Diarrheal Diseases, Global Health, Bill & Melinda Gates Foundation, Seattle, Washington.

Recognizing that enteric fever disproportionately affects the poorest and the most vulnerable communities that have limited access to improved sanitation, safe water sources, and optimal medical care, the Bill & Melinda Gates Foundation has funded efforts to augment global understanding of the disease since the foundation's inception. At the turn of the century, early efforts focused on characterizing the burden of disease in Asia and evaluating use of the available Vi-polysaccharide vaccines through the Diseases of the Most Impoverished projects at the International Vaccine Institute (IVI). More recent efforts have centered on supporting development of typhoid conjugate vaccines and expanding disease surveillance efforts into Africa, as well as generating a greater understanding of the clinical severity and sequelae of enteric fever in Africa, Asia, and India. Read More

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https://academic.oup.com/cid/article/68/Supplement_1/S42/532
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http://dx.doi.org/10.1093/cid/ciy928DOI Listing
February 2019
7 Reads

Six-month follow up of a randomized clinical trial-phase I study in Indonesian adults and children: Safety and immunogenicity of Salmonella typhi polysaccharide-diphtheria toxoid (Vi-DT) conjugate vaccine.

PLoS One 2019 13;14(2):e0211784. Epub 2019 Feb 13.

PT. Bio Farma, Bandung, Indonesia.

Introduction: There is a high global incidence of typhoid fever, with an annual mortality rate of 200,000 deaths. Typhoid fever also affects younger children, particularly in resource-limited settings in endemic countries. Typhoid vaccination is an important prevention tool against typhoid fever. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211784PLOS
February 2019

Changing trends and pretravel preparation of business travelers from Greece during the financial crisis.

Public Health 2019 Feb 7. Epub 2019 Feb 7.

Department for Interventions in Healthcare Facilities, Hellenic Centre for Disease Control and Prevention, Athens, Greece. Electronic address:

Objectives: Unemployment in Greece has been increasing as a result of the financial crisis. The aim of this study was to assess the changing trends of business travelers and their pretravel preparation.

Study Design: Prospective, questionnaire-based study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00333506183040
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http://dx.doi.org/10.1016/j.puhe.2018.12.015DOI Listing
February 2019
1 Read

Cryo-EM structure of the homohexameric T3SS ATPase-central stalk complex reveals rotary ATPase-like asymmetry.

Nat Commun 2019 Feb 7;10(1):626. Epub 2019 Feb 7.

Department of Biochemistry and Molecular Biology and the Center for Blood Research, University of British Columbia, Vancouver, BC, Canada.

Many Gram-negative bacteria, including causative agents of dysentery, plague, and typhoid fever, rely on a type III secretion system - a multi-membrane spanning syringe-like apparatus - for their pathogenicity. The cytosolic ATPase complex of this injectisome is proposed to play an important role in energizing secretion events and substrate recognition. We present the 3. Read More

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http://www.nature.com/articles/s41467-019-08477-7
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http://dx.doi.org/10.1038/s41467-019-08477-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367419PMC
February 2019
4 Reads

Helicobacter pylori infection and risk of salmonella infection.

Medicine (Baltimore) 2019 Feb;98(6):e14335

Hepatology, Gastroenetrology and Infectious Diseases Department, Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh.

Helicobacter pylori (H pylori) infection is the most frequent infection worldwide and it has been postulated that it predisposes to multiple enteric pathogens and diarrheal diseases. Salmonella infection is common in tropical and under developed communities and is associated with wide range of diseases from gastroenteritis to typhoid fever. This study aimed at detecting the impact of H pylori infection on the incidence of salmonella infections. Read More

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http://dx.doi.org/10.1097/MD.0000000000014335DOI Listing
February 2019
3 Reads

β-Glucan of Candida albicans Cell Wall Extract Inhibits Salmonella Typhimurium Colonization by Potentiating Cellular Immunity (CD8 + and CD4 + T Cells).

Rev Soc Bras Med Trop 2019 Jan 31;52:e20180254. Epub 2019 Jan 31.

Medicine Study Program, Faculty of Medicine, Universitas Brawijaya, Indonesia.

Introduction: Antimicrobial resistance has been reported in the drugs used for the treatment of typhoid fever. The immunomodulatory substance β-glucan can be used as an alternative therapy as it potentiates host immunity. The aims of this study are to observe the effect of Candida albicans cell wall (CCW) extract towards host immunity (TCD8+ and TCD4+ cells in spleen, intestinal sIgA) and its capacity to kill Salmonella in the intestine and liver of typhoid fever mice models. Read More

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http://dx.doi.org/10.1590/0037-8682-0254-2018DOI Listing
January 2019
1 Read

Intravesical Ty21a vaccine promotes dendritic cells and T cell-mediated tumor regression in the MB49 bladder cancer model.

Cancer Immunol Res 2019 Jan 29. Epub 2019 Jan 29.

Dpt of Urology, Centre Hospitalier Universitaire Vaudois and University of Lausanne

Preclinical data shows that intravesical instillation of Ty21a/Vivotif®, a commercial vaccine against typhoid fever, is an effective alternative option to standard Bacillus-Calmette-Guérin (BCG) immunotherapy for nonmuscle-invasive bladder cancer (NMIBC). Here we characterized the inflammatory effects of Ty21a on the bladder and investigated the immune mechanisms underlying tumor-regression towards the use of this bacterial vaccine in NMIBC patients. MB49 bladder tumor-bearing mice had significantly improved survival after intravesical instillations of Ty21a doses of 106 to 108 colony-forming units. Read More

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0671DOI Listing
January 2019
5 Reads

Structural and Physiological Exploration of Typhi YfdX Uncovers Its Dual Function in Bacterial Antibiotic Stress and Virulence.

Front Microbiol 2018 14;9:3329. Epub 2019 Jan 14.

Disease Target Structure Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, South Korea.

YfdX is a prokaryotic protein encoded by several pathogenic bacteria including serovar Typhi, which causes one of the most fatal infectious diseases, typhoid fever. YfdX is a product of the operon and is known to be under the control of EvgA, a regulator protein controlling the expression of several proteins involved in response to environmental stress, in . Nevertheless, unlike other proteins encoded by the same operon, the structural and physiological aspects of YfdX have been poorly characterized. Read More

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http://dx.doi.org/10.3389/fmicb.2018.03329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6339873PMC
January 2019
1 Read
3.941 Impact Factor

Incidence of dengue illness among children in an urban setting in South India: A population based study.

Int J Infect Dis 2019 Jan 24. Epub 2019 Jan 24.

Department of Community Health, Christian Medical College, Vellore, Tamil Nadu, 632004, India. Electronic address:

Objectives: Our main objective was to estimate population based dengue incidence estimates in children with fever >3 days.

Methods: The study used the 'National Surveillance System for Enteric Fever in India' (NSSEFI) cohort at the Vellore site. Children aged 6 months to 14 years from a peri-urban setting in Vellore were followed up for a year for the presence of fever. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.01.033DOI Listing
January 2019
2 Reads

A Review on Blighia Sapida K.D. Koenig (syn. Cupania sapida Voigt.)'s: Its Economic Importance, Phytochemistry and Pharmacological Activity: Channeling these Claims for the Present and Future.

J Ethnopharmacol 2019 Jan 24. Epub 2019 Jan 24.

Dept. of Applied Chemistry, Federal University Dutsin-Ma, Katsina State, Nigeria; National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS 38677, USA.

Ethnopharmacological Relevance: Ackee plant (Blighia sapida K. D. Koenig) (Sapindaceae) is used in Sub-Saharan African where it has its origin and in different parts of the world (The Caribbean, North and South America, Europe) traditionally to manage numerous ailments like backache, constipation, cancer, fever in young children, gonorrhea, dysentery, psychosis, hernia, stomach ache, malaria, rheumatism, typhoid and several others. Read More

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http://dx.doi.org/10.1016/j.jep.2019.01.017DOI Listing
January 2019
6 Reads

Bioethics of establishing a CHIM model for dengue vaccine development.

Int J Infect Dis 2019 Jan 11. Epub 2019 Jan 11.

Departments of Community Health, Bioethics, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address:

Introduction: Controlled human infection models (CHIM) have been used in vaccine development to up-select and down-select potential vaccine candidates and to provide proof of vaccine efficacy, and have also been used as a basis for licensure of vaccines for cholera and typhoid by regulatory agencies.

Chim In Dengue Vaccines Development: Dengue fever results in ∼400 million infections a year and is of significant health concern especially in India. There are currently no antivirals for the disease and the only licensed vaccine for dengue is not widely used owing to safety concerns. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S12019712193002
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http://dx.doi.org/10.1016/j.ijid.2019.01.013DOI Listing
January 2019
6 Reads

Emergence of Extensively Drug-Resistant Salmonella Typhi Infections Among Travelers to or from Pakistan - United States, 2016-2018.

MMWR Morb Mortal Wkly Rep 2019 Jan 11;68(1):11-13. Epub 2019 Jan 11.

In February 2018, a typhoid fever outbreak caused by Salmonella enterica serotype Typhi (Typhi), resistant to chloramphenicol, ampicillin, trimethoprim-sulfamethoxazole, fluoroquinolones, and third-generation cephalosporins, was reported in Pakistan. During November 2016-September 2017, 339 cases of this extensively drug-resistant (XDR) Typhi strain were reported in Pakistan, mostly in Karachi and Hyderabad; one travel-associated case was also reported from the United Kingdom (1). More cases have been detected in Karachi and Hyderabad as surveillance efforts have been strengthened, with recent reports increasing the number of cases to 5,372 (2). Read More

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http://www.cdc.gov/mmwr/volumes/68/wr/mm6801a3.htm?s_cid=mm6
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http://dx.doi.org/10.15585/mmwr.mm6801a3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342547PMC
January 2019
8 Reads

Expanded table: Some vaccines for travelers.

Authors:

Med Lett Drugs Ther 2018 Nov 19;60(1560):e192-e194. Epub 2018 Nov 19.

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November 2018
9 Reads

Vaccines for travelers.

Authors:

Med Lett Drugs Ther 2018 Nov;60(1560):185-192

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November 2018
10 Reads

Identifying different types of flood-sensitive diarrheal diseases from 2006 to 2010 in Guangxi, China.

Environ Res 2019 Mar 31;170:359-365. Epub 2018 Dec 31.

Department of Epidemiology, School of Public Health, Shandong University, Jinan, Shandong Province 250012, People's Republic of China; Shandong University Climate Change and Health Center, Jinan, Shandong Province 250012, People's Republic of China. Electronic address:

Floods may influence different types of diarrheal diseases and epidemiological studies of pathogen-specific diarrhea due to floods in China are still needed. In addition, few studies have been conducted to quantify the lag and cumulative risk of diarrheal disease due to floods in Guangxi, China. Our study aimed to identify different types of diarrheal diseases that were sensitive to floods and to quantify their lag and cumulative impact. Read More

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http://dx.doi.org/10.1016/j.envres.2018.12.067DOI Listing
March 2019
3 Reads
4.373 Impact Factor

serovar Typhi osteomyelitis in a young adult with sickle cell and thalassemia traits: A possible association.

IDCases 2019 24;15:e00478. Epub 2018 Dec 24.

University of Maryland Medical Center Midtown Campus, 827 Linden Avenue, Baltimore, MD, 21201, United States.

osteomyelitis is known to occur in immunocompromised and sickle cell disease patients. It rarely occurs in other hosts. We present a case of chronic femoral osteomyelitis due to serovar Typhi seen in a Maryland resident. Read More

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http://dx.doi.org/10.1016/j.idcr.2018.e00478DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317299PMC
December 2018
2 Reads

Host-pathogen interactions in typhoid fever: the model is the message.

Ann Transl Med 2018 Nov;6(Suppl 1):S38

Departamento de Genética, Facultad de Biología, Universidad de Sevilla, Sevilla, Spain.

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http://atm.amegroups.com/article/view/21702/21830
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http://dx.doi.org/10.21037/atm.2018.09.52DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291556PMC
November 2018
1 Read

Typhoid Fever Accompanied With Hematopoetic Lymphohistiocytosis and Rhabdomyolysis in a Refugee Child.

J Pediatr Hematol Oncol 2019 Jan 2. Epub 2019 Jan 2.

Departments of Pediatric Hematology and Oncology.

Typhoid fever is an acute and systemic infectious disease that is specific to humans and is caused by Salmonella typhi. Patients may present with different findings ranging from simple fever to multiple organ failure. Hemophagocytosis and rhabdomyolysis are rare complications of typhoid fever. Read More

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http://dx.doi.org/10.1097/MPH.0000000000001400DOI Listing
January 2019
9 Reads

Association of typhoid fever with anti-NMDAR encephalitis in a young child.

J Neuroimmunol 2019 Mar 27;328:76-77. Epub 2018 Dec 27.

Opthalmology and Corneal Surgery, SK Soni Hospital, Jaipur, India.

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http://dx.doi.org/10.1016/j.jneuroim.2018.12.006DOI Listing
March 2019
1 Read

The HPAfrica protocol: Assessment of health behaviour and population-based socioeconomic, hygiene behavioural factors - a standardised repeated cross-sectional study in multiple cohorts in sub-Saharan Africa.

BMJ Open 2018 Dec 19;8(12):e021438. Epub 2018 Dec 19.

International Vaccine Institute, Gwanak-gu, Seoul, Republic of Korea.

Introduction: The objective of the Health Population Africa (HPAfrica) study is to determine health behaviour and population-based factors, including socioeconomic, ethnographic, hygiene and sanitation factors, at sites of the Severe Typhoid Fever in Africa (SETA) programme. SETA aims to investigate healthcare facility-based fever surveillance in Burkina Faso, the Democratic Republic of the Congo, Ethiopia, Ghana, Madagascar and Nigeria. Meaningful disease burden estimates require adjustment for health behaviour patterns, which are assumed to vary among a study population. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2017-02143
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http://dx.doi.org/10.1136/bmjopen-2017-021438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303690PMC
December 2018
10 Reads
2.063 Impact Factor

In Silico Characterization of B Cell and T Cell Epitopes for Subunit Vaccine Design of Salmonella typhi PgtE: A Molecular Dynamics Simulation Approach.

J Comput Biol 2019 Feb 14;26(2):105-116. Epub 2018 Dec 14.

4 Data Mining and Text Mining Laboratory, Department of Bioinformatics, Bharathiar University , Coimbatore, India .

Typhoid fever is an acute illness in humans, caused by Salmonella typhi, a gram-negative bacterium. Outer membrane proteins of S. typhi have strong potential for its use in the development of subunit vaccine against typhoid. Read More

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http://dx.doi.org/10.1089/cmb.2018.0010DOI Listing
February 2019

Loop-mediated isothermal amplification-based detection of typhoid fever on an automated Genie II Mk2 system - A case-control-based approach.

Acta Trop 2019 Feb 5;190:293-295. Epub 2018 Dec 5.

Infectious Diseases Epidemiology, Bernhard-Nocht Institute for Tropical Medicine Hamburg, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany; German Center for Infection Research (DZIF), Hamburg-Borstel-Lübeck, Germany.

Typhoid fever, caused by the bacterium Salmonella enterica subsp. enterica serovar Typhi, is an important cause of blood stream infections in the tropics, for which easy-to-apply molecular diagnostic approaches are desirable. The diagnostic performance of a newly introduced and a previously described loop-mediated isothermal amplification (LAMP) approach using different primer sets on a Genie II Mk2 device for the identification of Salmonella enterica ssp. Read More

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http://dx.doi.org/10.1016/j.actatropica.2018.12.004DOI Listing
February 2019
1 Read

21st-century typhoid fever-progression of knowledge but regression of control?

Authors:
Karen H Keddy

Lancet Infect Dis 2018 Dec;18(12):1296-1298

Faculty of Health Sciences, University of the Witwatersrand, Johannesburg 2000, South Africa. Electronic address:

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http://dx.doi.org/10.1016/S1473-3099(18)30515-2DOI Listing
December 2018
1 Read

Emergence of Multi-Resistant Enteric Infection In A Paediatric Unit Of Karachi, Pakistan.

J Pak Med Assoc 2018 Dec;68(12):1848-1850

Postgraduate trainee, Department of Paediatrics, Abbasi Shaheed Hospital, Karachi Medical and Denatl College.

From June 2018, onwards, there has been an upsurge of multi-resistant enteric infections in children admitted from various catchment areas of Abbasi Shaheed Hospital (ASH). This is a serious concern as very few antibiotics are available to treat the children. Children from June 2018 to September 2018 of age groups 5. Read More

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December 2018
3 Reads

The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.

Nat Commun 2018 11 30;9(1):5094. Epub 2018 Nov 30.

The Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 764 Vo Van Kiet, Quant 5, Ho Chi Minh City, Vietnam.

There is paucity of data regarding the geographical distribution, incidence, and phylogenetics of multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa. Here we present a phylogenetic reconstruction of whole genome sequenced 249 contemporaneous S. Typhi isolated between 2008-2015 in 11 sub-Saharan African countries, in context of the 2,057 global S. Read More

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http://www.nature.com/articles/s41467-018-07370-z
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http://dx.doi.org/10.1038/s41467-018-07370-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269545PMC
November 2018
18 Reads
10.742 Impact Factor

Identification of a Small Molecule Anti-biofilm Agent Against .

Front Microbiol 2018 20;9:2804. Epub 2018 Nov 20.

Department of Microbial Infection and Immunity, Infectious Diseases Institute, The Ohio State University, Columbus, OH, United States.

Biofilm formation is a common strategy utilized by bacterial pathogens to establish persistence in a host niche. serovar Typhi, the etiological agent of Typhoid fever, relies on biofilm formation in the gallbladder to chronically colonize asymptomatic carriers, allowing for transmission to uninfected individuals. serovar Typhimurium utilizes biofilms to achieve persistence in human and animal hosts, an issue of both clinical and agricultural importance. Read More

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http://dx.doi.org/10.3389/fmicb.2018.02804DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6256085PMC
November 2018
2 Reads

Virulotyping of Salmonella enterica serovar Typhi isolates from Pakistan: Absence of complete SPI-10 in Vi negative isolates.

PLoS Negl Trop Dis 2018 11 30;12(11):e0006839. Epub 2018 Nov 30.

Department of Immunology, Microbiology and Parasitology, University of the Basque Country, (UPV/EHU), Vitoria-Gasteiz, Spain.

The pathogenesis of Salmonella enterica serovar Typhi (S. Typhi), the cause of typhoid fever in humans, is mainly attributed to the acquisition of horizontally acquired DNA elements. Salmonella pathogenicity islands (SPIs) are indubitably the most important form of horizontally acquired DNA with respect to pathogenesis of this bacterium. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6267989PMC
November 2018
1 Read

In silico epitope identification of unique multidrug resistance proteins from Salmonella Typhi for vaccine development.

Comput Biol Chem 2019 Feb 22;78:74-80. Epub 2018 Nov 22.

Structural Biology Laboratory, Department of Bioinformatics, Bharathiar University, Coimbatore, 641046, Tamilnadu, India.

Typhoid fever is a multisystemic illness caused by Salmonella enterica serovars Typhi and is resistant to most antibiotics and drugs. The resistance is conferred through multidrug resistance (MDR) proteins, which efflux most antibiotics and other drugs. We predicted potential candidate B-cell and T-cell epitopes using bio- and immune-informatics tools in the 11 MDR proteins - EmrA, EmrB, EmrD, MdtA, MdtB, MdtC, MdtG, MdtH, MdtK, MdtL and TolC. Read More

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http://dx.doi.org/10.1016/j.compbiolchem.2018.11.020DOI Listing
February 2019
9 Reads

Spatial and temporal heterogeneities of district-level typhoid morbidities in Ghana: A requisite insight for informed public health response.

PLoS One 2018 29;13(11):e0208006. Epub 2018 Nov 29.

ECHO Research Group International, Aflao, Ghana.

Typhoid fever is estimated to cause between 9.9-24.2 million cases and 75,000-208,000 deaths per year globally. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0208006PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6264858PMC
November 2018
2 Reads

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Serovar Typhi.

Front Cell Infect Microbiol 2018 14;8:402. Epub 2018 Nov 14.

Department of Biological Sciences, Sunway University, Bandar Sunway, Malaysia.

Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of serovar Typhi. While new drug development strategies are being devised to combat the threat posed by these MDR pathogens, drug repurposing or repositioning has become a good alternative. The latter is considered mainly due to its capacity for saving sufficient time and effort for pre-clinical and optimization studies. Read More

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http://dx.doi.org/10.3389/fcimb.2018.00402DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6246918PMC
November 2018
1 Read

Improving Our Understanding of Serovar Paratyphi B through the Engineering and Testing of a Live Attenuated Vaccine Strain.

mSphere 2018 11 28;3(6). Epub 2018 Nov 28.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

Enteric fever is caused by three serovars: Typhi, Paratyphi A, and Paratyphi B Although vaccines against two of these serovars are licensed (Typhi) or in clinical development (Paratyphi A), as yet there are no candidates for Paratyphi B. To gain genomic insight into these serovars, we sequenced 38 enteric fever-associated strains from Chile and compared these with reference genomes. Each of the serovars was separated genomically based on the core genome. Read More

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http://dx.doi.org/10.1128/mSphere.00474-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262260PMC
November 2018
1 Read

Prevention of enteric fever in travellers with typhoid conjugate vaccines.

J Travel Med 2018 Jan;25(1)

Oxford Vaccine Group, Department of Paediatrics, University of Oxford.

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https://academic.oup.com/jtm/advance-article/doi/10.1093/jtm
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http://dx.doi.org/10.1093/jtm/tay120DOI Listing
January 2018
11 Reads

Typhoid fever complicated by cholecystitis in a 10-year-old boy.

J Paediatr Child Health 2018 Nov 25. Epub 2018 Nov 25.

Department of Infectious Disease, Royal Hobart Hospital, Hobart, Tasmania, Australia.

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http://dx.doi.org/10.1111/jpc.14312DOI Listing
November 2018
2 Reads

Modelling the cost-effectiveness of a rapid diagnostic test (IgMFA) for uncomplicated typhoid fever in Cambodia.

PLoS Negl Trop Dis 2018 11 19;12(11):e0006961. Epub 2018 Nov 19.

Department of Global Health and Development, Faculty of Public Health and Policy, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Typhoid fever is a common cause of fever in Cambodian children but diagnosis and treatment are usually presumptive owing to the lack of quick and accurate tests at an initial consultation. This study aimed to evaluate the cost-effectiveness of using a rapid diagnostic test (RDT) for typhoid fever diagnosis, an immunoglobulin M lateral flow assay (IgMFA), in a remote health centre setting in Cambodia from a healthcare provider perspective. A cost-effectiveness analysis (CEA) with decision analytic modelling was conducted. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006961
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http://dx.doi.org/10.1371/journal.pntd.0006961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277117PMC
November 2018
11 Reads

Manipulation of Typhi Gene Expression Impacts Innate Cell Responses in the Human Intestinal Mucosa.

Front Immunol 2018 1;9:2543. Epub 2018 Nov 1.

Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.

Although immunity induced by typhoid fever is moderated and short-lived, typhoid vaccination with the attenuated Ty21a oral vaccine generates long-lasting protection rates reaching up to 92%. Thus, there are important differences on how wild-type and typhoid vaccine strains stimulate host immunity. We hypothesize that vaccine strains with different mutations might affect gut inflammation and intestinal permeability by different mechanisms. Read More

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http://dx.doi.org/10.3389/fimmu.2018.02543DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6221971PMC
November 2018
3 Reads

Multi-drug resistant Salmonella enterica serovar Typhi isolates with reduced susceptibility to ciprofloxacin in Kenya.

BMC Microbiol 2018 Nov 14;18(1):187. Epub 2018 Nov 14.

Centre for Microbiology Research, Kenya Medical Research Institute, Nairobi, Kenya.

Background: Typhoid fever remains a public health concern in developing countries especially among the poor who live in informal settlements devoid of proper sanitation and clean water supply. In addition antimicrobial resistance poses a major challenge in management of the disease. This study assessed the antimicrobial susceptibility patterns of Salmonella enterica serotype Typhi (S. Read More

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http://dx.doi.org/10.1186/s12866-018-1332-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6236932PMC
November 2018
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Evaluating PCR-Based Detection of Typhi and Paratyphi A in the Environment as an Enteric Fever Surveillance Tool.

Am J Trop Med Hyg 2019 Jan;100(1):43-46

Child Health Research Foundation, Department of Microbiology, Dhaka Shishu Hospital, Dhaka, Bangladesh.

With prequalification of a typhoid conjugate vaccine by the World Health Organization, countries are deciding whether and at what geographic scale to provide the vaccine. Optimal local data to clarify typhoid risk are expensive and often unavailable. To determine whether quantitative polymerase chain reaction (qPCR) can be used as a tool to detect typhoidal DNA in the environment and approximate the burden of enteric fever, we tested water samples from urban Dhaka, where enteric fever burden is high, and rural Mirzapur, where enteric fever burden is low and sporadic. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6335896PMC
January 2019
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Serovar Typhi in Bangladesh: Exploration of Genomic Diversity and Antimicrobial Resistance.

MBio 2018 11 13;9(6). Epub 2018 Nov 13.

Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center, Rotterdam, the Netherlands.

Typhoid fever, caused by serovar Typhi, is a global public health concern due to increasing antimicrobial resistance (AMR). Characterization of Typhi genomes for AMR and the evolution of different lineages, especially in countries where typhoid fever is endemic such as Bangladesh, will help public health professionals to better design and implement appropriate preventive measures. We studied whole-genome sequences (WGS) of 536 Typhi isolates collected in Bangladesh during 1999 to 2013 and compared those sequences with data from a recent outbreak in Pakistan reported previously by E. Read More

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http://mbio.asm.org/lookup/doi/10.1128/mBio.02112-18
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http://dx.doi.org/10.1128/mBio.02112-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234861PMC
November 2018
15 Reads

In trauma, expect the unexpected: a rare case of post-traumatic pancreatitis associated with salmonellosis and enterocolitis.

BMJ Case Rep 2018 Nov 8;2018. Epub 2018 Nov 8.

Department of Pediatric Surgery, Children's Health Children's Medical Center Dallas, Dallas, Texas, USA.

A 16-year-old Hispanic man was transferred to our level I paediatric trauma centre with pancreatitis. Ten days prior, he had sustained a gunshot wound to the abdomen requiring an exploratory laparotomy for repair of a traumatic left diaphragmatic injury. Additional injuries included gastric, renal, liver and pancreatic lacerations as well as a T12 burst fracture that resulted in paraplegia. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22628
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http://dx.doi.org/10.1136/bcr-2018-226286DOI Listing
November 2018
4 Reads

Epidemiological and Clinical Features of Typhi Infection Among Adult Patients in Qatar: A Hospital-based Study.

Oman Med J 2018 Nov;33(6):468-472

Department of Microbiology, Hamad General Hospital, Doha, Qatar.

Objectives: We sought to describe the epidemiological and clinical features of typhoid fever in Qatar.

Methods: We conducted a retrospective study of adult patients treated for typhoid fever at Hamad General Hospital and Alkhor Hospital between 2005 and 2012.

Results: The mean age of the 354 patients enrolled in the study was 28. Read More

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http://omjournal.org/articleDetails.aspx?coType=1&aId=23
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http://dx.doi.org/10.5001/omj.2018.87DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6206420PMC
November 2018
10 Reads

Sero-prevalence and associated risk factors of Brucellosis among Malaria negative febrile out-patients in Wakiso district, Central Uganda.

BMC Res Notes 2018 Nov 8;11(1):803. Epub 2018 Nov 8.

Department of Biomolecular Resources and Biolab Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P.O. Box 7062, Kampala, Uganda.

Objective: Brucellosis is a zoonotic disease usually acquired through direct contact with the infected animals and consumption of contaminated milk and meat products. In humans Brucellosis presents similar signs with other febrile diseases like Malaria, typhoid and other febrile conditions. This study was carried out to determine the prevalence of Brucella abortus among patients with fever but were negative for Malaria. Read More

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https://bmcresnotes.biomedcentral.com/articles/10.1186/s1310
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http://dx.doi.org/10.1186/s13104-018-3907-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6225581PMC
November 2018
16 Reads