3,234,698 results match your criteria Tumors of the Conus and Cauda Equina


Potential Role of microRNA-183 as a Tumor Suppressor in Hepatocellular Carcinoma.

Cell Physiol Biochem 2018 Dec 6;51(5):2065-2072. Epub 2018 Dec 6.

Department of General Surgery of East District, The Second Hospital of Hebei Medical University, Shijiazhuang,

Background/aims: Disseminated tumors, known as metastases, are responsible for ninety-percent of mortality due to cancer. Epithelial to mesenchymal transition, a phenomenon required for morphological conversion of non-motile discoid shaped epithelial cells to highly motile spindle-shaped mesenchymal cells, is thought to be a pre-requisite for metastatic progression. Metastasis-associated 1 (MTA1) protein is a prime inducer of EMT and metastatic progression in all solid tumors including hepatocellular carcinoma (HCC). Read More

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December 2018
8 Reads

Long-term seizure outcome in frontal lobe epilepsy surgery.

Epilepsy Behav 2018 Dec 3;90:93-98. Epub 2018 Dec 3.

IRCCS "NEUROMED", Pozzilli, IS, Italy; Department of Neurology and Psychiatry, "Sapienza" University of Rome, Italy.

Purpose: The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery.

Method: This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001-2014), followed up for at least 2 years (mean: 8.7 years). Read More

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December 2018
2 Reads

Discovery and development of small molecule modulators targeting glutamine metabolism.

Eur J Med Chem 2018 Nov 28;163:215-242. Epub 2018 Nov 28.

Jiangsu Key Laboratory of Drug Design and Optimization, Department of Medicinal Chemistry, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. Electronic address:

Cancer cells have been confirmed diverge significantly from normal cells on the metabolic properties. Energy production in cancer cells is abnormally dependent on the glycolysis pathway and other atypical metabolic characteristics such as increased fatty acid synthesis and increased rates of glutamine metabolism. Among these metabolic features of cancers, glutamine metabolism has been reported to be the main energy supply for the growth and viability of a potentially large subset of malignant tumors. Read More

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November 2018
5 Reads
3.447 Impact Factor

PD-1/ PD-L1 blockade as a novel treatment for colorectal cancer.

Biomed Pharmacother 2018 Dec 3;110:312-318. Epub 2018 Dec 3.

Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Colorectal cancer (CRC), as a prominent cause of cancer-related deaths, has historically been notable worldwide and many attempts have been made to raise the overall survival of CRC patients. Immune response has long been a question of great interest in a wide range of fields such as cancer therapies and anti-tumor immunity through checkpoint inhibitors, specifically anti PD-1/ PD-L1 interaction, is a new line of research for treatment of CRC patients. Following the successful development of anti-PD-1 for melanoma, renal cell carcinoma, and non-small cell lung cancer, several clinical trials have been conducted on monoclonal antibodies (MAbs) against PD-1 in CRC. Read More

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December 2018
9 Reads

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2018 Nov 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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November 2018
2 Reads

Early impact of pulmonary stereotactic fractionated body radiotherapy (SBRT) on Quality of Life (QoL): Benefit for patients with low initial scores (STRIPE trial).

J Thorac Oncol 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiation Oncology, Medical Center, Faculty of Medicine, University of Freiburg, Germany; German Cancer Consortium (DKTK) Partner Site Freiburg, Germany; German Cancer Research Center (DKFZ), Heidelberg, Germany.

Introduction: Quality of life (QoL) of comorbid patients with pulmonary malignancies is a key issue in considering stereotactic fractionated body radiotherapy (SBRT) indication. This study investigates the early impact of SBRT on QoL.

Methods: 100 patients with pulmonary lesions were treated with SBRT from 02/2011 to 11/2014 within the prospective, monocenter, phase II STRIPE trial. Read More

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December 2018
2 Reads

Ultrasonic scalpel-assisted endoscopic endonasal surgery of infratemporal fossa: our first impressions.

World Neurosurg 2018 Dec 3. Epub 2018 Dec 3.

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, HNS&FDRc, University of Insubria, Varese, Italy.

Background: Endoscopic endonasal transpterygoid approach is emerging as a valid option for treating selected tumors in the infratemporal fossa. Compared to traditional open approaches, the endoscopic endonasal approach (EEA) presents more difficulty in controlling bleeding and less choice in surgical instruments for endoscopic tumor dissection, which is often performed with bipolar forceps or steel dissectors.

Case Description: We describe the use of an ultrasonic scalpel device for performing endoscopic endonasal resection of two rare infratemporal fossa tumors (mature teratoma and hemangiopericytoma), which has not been reported in the literature so far. Read More

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December 2018
1 Read

Cytochrome P450 epoxygenases and cancer: A genetic and a molecular perspective.

Pharmacol Ther 2018 Dec 3. Epub 2018 Dec 3.

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;; Department of Veterans Affairs, Nashville, TN, USA. Electronic address:

Cytochrome CYP450 epoxygenases catalyze the epoxidation of polyunsaturated fatty acids including arachidonic acid, eicosapentaenoic acid, and docosahexaenoic acid. The arachidonic acid-derived products are potent pro-angiogenic lipids and promote tumor development and growth. On the other hand, eicosapentaenoic acid- and docosahexaenoic acid-derived products inhibit angiogenesis and play a protective role in certain pathological conditions including cancer. Read More

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December 2018
2 Reads

Cabazitaxel and Thymoquinone co-loaded Lipospheres as a Synergistic Combination for Breast Cancer.

Chem Phys Lipids 2018 Dec 3. Epub 2018 Dec 3.

Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, 500037, India. Electronic address:

Cabazitaxel as microtubule inhibitor and thymoquinone as HDAC inhibitor affects the important genes like p53, STAT3, Bax, BCL-2, p21 and down regulation of NF-κB are reported for potential activity against breast tumors. However, poor aqueous solubility and permeability hinders the delivery of these drugs to target site. To address the delivery challenges cabazitaxel and thymoquinone co-loaded lipospheres were developed. Read More

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December 2018

MicroRNA-19a regulates the proliferation, migration and invasion of human gastric cancer cells by targeting CUL5.

Arch Biochem Biophys 2018 Dec 3. Epub 2018 Dec 3.

Department of General Surgery, The First People's Hospital of Yunnan Province, Kunming, Yunnan, 650032, China. Electronic address:

Gastric cancer is one of the prevalent types of cancers and despite improvements in its treatment, the overall survival is still far from descent. The dearth of efficient biomarkers, chemotherapeutic agents and therapeutic targets form a major hurdle in the treatment of the gastric cancer. Accumulating evidences suggest that MicroRNAs (miRs) may prove important therapeutic targets/agents for the management of cancers including gastric cancer. Read More

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December 2018

[Syndrome of vertebral destruction: understanding to practice].

Acta Ortop Mex 2018 May-Jun;32(3):182-187

Hospital Centro Médico de Occidente. Instituto Mexicano del Seguro Social (IMSS). Guadalajara, Jalisco. México.

The term «vertebral destruction syndrome» comprises pathologies causing structural changes in the spine, mainly in the vertebral body, producing mechanical deformity and neurological involvement. The pathologies found in this definition may be infectious, metabolic or tumoral. Vertebral osteomyelitis is a disease that occurs mainly in adults > 50 years; we speak of spondylodiscitis when the condition affects the disc and vertebral body. Read More

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December 2018
1 Read

Mismatch repair deficiency and aberrations in the Notch and Hedgehog pathways are of prognostic value in patients with endometrial cancer.

PLoS One 2018 6;13(12):e0208221. Epub 2018 Dec 6.

Laboratory of Molecular Oncology, Hellenic Foundation for Cancer Research/Aristotle University of Thessaloniki, Thessaloniki, Greece.

The aim of this study was to investigate the prognostic value of the Hedgehog (Gli, Patched-1, Shh, Smo) and Notch (Jag1, Notch2, Notch3) pathway members, in comparison to a panel of proteins (ER, PgR, HER2/neu, Ki67, p53, p16, PTEN and MMR) previously suggested to be involved in the pathogenesis of endometrial cancer, in association with clinical outcome and standard clinicopathological characteristics. A total of 204 patients with histological diagnosis of endometrial cancer treated from 2004 to 2013 were included. The evaluation of protein expression was assessed by immunohistochemistry. Read More

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December 2018
1 Read

GLUT3 expression in cystic change induced by hypoxia in pituitary adenomas.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

S Wang, Neurosurgery, Fuzhou General Hospital, Fuzhou, China., Fuzhou, China.

Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high energy metabolisms. Read More

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December 2018
1 Read

ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling.

Endocr Connect 2018 Dec;7(12):1397-1408

Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, USA.

We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the expression levels of androgen receptor (AR) correlated with those of phospho-ATF2. Dihydrotestosterone treatment in AR-positive bladder cancer cells also induced the expression of phospho-ATF2 and phospho-ERK as well as nuclear translocation and transcriptional activity of ATF2. Read More

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December 2018

Pancreas divisum: a reemerging risk factor for pancreatic diseases.

Authors:
Serghei Covantev

Rom J Intern Med 2018 Dec;56(4):233-242

Laboratory of Allergology and Clinical Immunology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, Chisinau, Republic of Moldova.

Pancreas divisum (PD) is the most common developmental anatomic variant of pancreatic duct. The attention towards the PD has grown significantly since there are reports that this condition may cause acute relapsing pancreatitis, chronic pancreatitis and chronic abdominal pain syndrome. Furthermore, over the years, there have been multiple reports of PD associated with different types of tumors. Read More

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December 2018
1 Read

Aggressive Angiomyxoma: A Rare Tumor of Male Pelvic Cavity.

Acta Med Port 2018 Nov 30;31(11):693-696. Epub 2018 Nov 30.

Department of General Surgery. Ankara University School of Medicine. Ankara. Turkey.

Aggressive angiomyxoma is an uncommon, benign, slow-growing, and locally infiltrative soft tissue neoplasm which is located primarily in the genital region and pelviperineal interstitial tissue of female patient in the fourth decade of life. Its occurrence in male patients is even more unusual and commonly appears at a later age. The mainstay of treatment typically involves surgical excision with tumor-free margins, and despite complete resection, local recurrences are common. Read More

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November 2018
1 Read

Molecular Staging of Patients with Colon Cancer. The C-Closer-II Study: A Multicentre Study in Portugal.

Acta Med Port 2018 Nov 30;31(11):661-669. Epub 2018 Nov 30.

Serviço de Cirurgia Geral. Hospital Garcia de Orta. Almada. Portugal.

Introduction: Approximately 20% - 30% of histological lymph node-negative patients with colorectal cancer relapse at five years after surgical treatment. This recurrence is likely due to occult nodal disease undetected by standard histopathological practice which has implications in terms of the clinical management of patients.

Material And Methods: Lymph nodes were collected from colectomy specimens. Read More

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November 2018
1 Read

Histological Subtypes and Clinical Behavior Evaluation of Salivary Gland Tumors.

Acta Med Port 2018 Nov 30;31(11):641-647. Epub 2018 Nov 30.

Department of Pathology. Centro Hospitalar São João. Porto. Unit of Pathology and Oncology. Department of Pathology. Faculdade de Medicina. Universidade do Porto. Porto. Portugal.

Introduction: Salivary gland tumors include a wide spectrum of histological subtypes and clinical behavior, which we aim to evaluate.

Material And Methods: We performed a retrospective study of all salivary gland tumors diagnosed and treated at the Centro Hospitalar São João, Porto, between 2005 and 2015. Histological re- evaluation was performed in all cases and patient files were reviewed and both clinical and follow-up data were collected. Read More

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November 2018
4 Reads

MMP14 empowers tumor-initiating breast cancer cells under hypoxic nutrient-depleted conditions.

FASEB J 2018 Dec 6:fj201801127R. Epub 2018 Dec 6.

Institute of Molecular Medicine and Cell Research, Medical Faculty, University of Freiburg, Freiburg, Germany.

Tumor-initiating cells (TICs) existing in breast cancer are thought to be involved in initiation, progression, and relapse of tumors. In these processes, the epithelial-to-mesenchymal transition (EMT) and proteases are crucial factors that also dependent on the tumor milieu, including hypoxic nutrient-deprived, as well as normoxic nutrient-rich, environments. Therefore, we investigated EMT and proteases in TICs and their response to different environments by means of a newly generated immortalized TIC (iTIC) line. Read More

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December 2018
1 Read

Graphene Quantum Dots-Mediated Theranostic Penetrative Delivery of Drug and Photolytics in Deep Tumors by Targeted Biomimetic Nanosponges.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

Dual targeted delivery of drugs and energy by nanohybrids can potentially alleviate side effects and improve the unique features required for precision medicine. To realize this aim, however, the hybrids which are often rapidly removal from circulation and piled up tumors periphery near the blood vessels must address the difficulties in low blood half-lives and tumor penetration. In this study, a sponge-inspired carbon composites-supported red blood cell (RBC) membrane that doubles as a stealth agent and photolytic carrier that transports tumor-penetrative agents (graphene quantum dots and docetaxel (GQD-D)) and heat with irradiation was developed. Read More

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December 2018

Prognosis of patients with prostate cancer and middle range prostate - specific antigen levels of 20 - 100 ng / mL.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.

Introduction: Prostate - specific antigen (PSA) is a useful biomarker for detection of prostate cancer (PCa) and for risk classification in addition to TNM classification and Gleason score (GS). We reported the role of PSA in patients with low (< 20 ng / mL) and extremely high (≥ 100 ng / mL) PSA levels. However, it is unclear whether a correlation exists between middle range PSA levels (20 - 100 ng / mL) at diagnosis and prognosis. Read More

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October 2018

The importance of histopathologic review of biopsies in patients with prostate cancer referred to a tertiary uro-oncology center.

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

Departamento de Anatomia Patológica da Universidade Estadual de Campinas - UNICAMP, Campinas, SP, Brasil.

Introduction: In view of the detailed histologic evaluation of prostate cancer (PC), it is usually advisable to provide a "second opinion" to confirm diagnosis. This study aimed to compare the Gleason score (GS) of initial diagnosis versus that of histopathologic review of patients with PC. The secondary objective was to compare initial GS versus histopathologic review versus post - surgical histopathology. Read More

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October 2018

Dramatic polarization in genitourinary expert opinions regarding the clinical utility of positron emission tomography (PET) imaging in prostate cancer.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Radiation Medicine, Oregon Health and Science University, Portland, OR, USA.

Objectives: To ascertain the opinions of North American genitourinary (GU) experts regarding inclusion of technologies such as prostate - specific membrane antigen (PSMA) and C - 11 choline positron emission tomography (PET) into routine practice.

Materials And Methods: A survey was distributed to North American GU experts. Questions pertained to the role of PSMA and C - 11 PET in PCa management. Read More

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October 2018
1 Read

Re: Incidence and treatment of malignant tumors of the genitourinary tract in renal transplant recipients.

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Reconstructive Urology, St Helens & Knowsley Hospital NHS Trust Whiston Hospital, Liverpool, United Kingdom.

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October 2018

Does the experience of the bedside assistant effect the results of robotic surgeons in the learning curve of robot assisted radical prostatectomy?

Int Braz J Urol 2018 Oct 20;44. Epub 2018 Oct 20.

American Hospital, Istanbul, Turkey.

Introduction: The success of the robot assisted radical prostatectomy (RARP) procedures depend on a successful team, however the literature focuses on the performance of a console surgeon. The aim of this study was to evaluate surgical outcomes of the surgeons during the learning curve in relation to the bedside assistant's experience level during RARP.

Materials And Methods: We retrospectively reviewed two non - laparoscopic, beginner robotic surgeon's cases, and we divided the patients into two groups. Read More

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October 2018
2 Reads

Small cell bladder cancer: should we consider prophylactic cranial irradiation?

Int Braz J Urol 2018 Oct 30;44. Epub 2018 Oct 30.

Department of Urology, University of Pittsburgh, Pennsylvania, U.S.A.

Purpose: To describe the clinical characteristics, treatment patterns, and outcomes in patients with small cell bladder cancer at our institution, including those who received prophylactic cranial irradiation (PCI) for the prevention of intracranial recurrence.

Materials And Methods: Patients with small cell bladder cancer treated at a single institution between January 1990 and August 2015 were identified and analyzed retrospectively for demographics, tumor stage, treatment, and overall survival.

Results: Of 44 patients diagnosed with small cell bladder cancer, 11 (25%) had metastatic disease at the time of presentation. Read More

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October 2018
1 Read

Breast cancer in males, case presentation and literature review

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):424-428. Epub 2018 Nov 30.

Instituto de Seguridad Social del Estado de México y Municipios, Centro Médico ISSEMyM Ecatepec, Servicio de Cirugía General. Ecatepec, Estado de México, México

Background: Male breast cancer is a rare entity, with an approximate rate of 1.1 / 100 000 in the US, with an average age of 67 years. In all cases a genetic study must be performed, in order to find mutations in known genes, and after the resolution of the disease, based on the results, a contralateral prophylactic mastectomy should be considered. Read More

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November 2018
1 Read

Chinese Expert Consensus Workshop Report: Guideline for permanent iodine-125 seed implantation of primary and metastatic lung tumors.

Thorac Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Interventional Medicine, The Second Hospital of Shandong University, Jinan, China.

Surgery remains the first choice of cure for early stage lung cancer. However, many patients are diagnosed at advanced stage, and thus miss the opportunity to undergo surgery. As such patients derive limited benefits from chemotherapy or radiotherapy, alternatives focusing on local control have emerged, including iodine-125 seed implantation. Read More

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December 2018
1 Read

The role of post-mastectomy radiotherapy in elderly patients with 1-3 positive lymph nodes breast cancer: An International Retrospective Double-Center Study.

Breast J 2018 Dec 6. Epub 2018 Dec 6.

Department of Radiation Oncology, Institut Curie, Paris, France.

This study evaluated the role of post-mastectomy radiotherapy (PMRT) in 111 patients with 1-3 positive nodes, aged 65 years or above between 2007 and 2013. In total, 64 received PMRT. The PMRT group had more aggressive tumor. Read More

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December 2018

The prevalence of human papillomavirus in oropharyngeal cancer is increasing regardless of sex or race, and the influence of sex and race on survival is modified by human papillomavirus tumor status.

Cancer 2018 Dec 6. Epub 2018 Dec 6.

Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Background: The purpose of this study was to evaluate the influence of sex and race/ethnicity upon prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC.

Method: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with OPC between 2010 and 2015. Outcomes were HPV status of tumor specimens and overall survival. Read More

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December 2018

Universal screening for Lynch Syndrome in a large consecutive cohort of Chinese colorectal cancer patients: high prevalence and unique molecular features.

Int J Cancer 2018 Dec 6. Epub 2018 Dec 6.

Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.

The prevalence of Lynch syndrome (LS) varies significantly in different populations, suggesting that ethnic features might play an important role. We enrolled 3330 consecutive Chinese patients who had surgical resection for newly diagnosed colorectal cancer. Universal screening for LS was implemented, including immunohistochemistry for mismatch repair (MMR) proteins, BRAF mutation test and germline sequencing. Read More

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December 2018
2 Reads
5.085 Impact Factor

Practice patterns of surgery for advanced ovarian cancer: analysis from international surveys.

Jpn J Clin Oncol 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background: We investigated the practice patterns of surgery for advanced ovarian cancer (AOC) through relevant international surveys.

Methods: After searching for 878 studies on surgery for AOC till 2017, we extracted 18 questions with similar query and answer formats from eight studies. Among them, 5 and 13 were classified as comprehensive and procedure information. Read More

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December 2018
3 Reads

Advances in Genomic Hepatocellular Carcinoma Research.

Gigascience 2018 Dec 6. Epub 2018 Dec 6.

Graduate School of Integrative Sciences and Engineering, National University of Singapore, 5 Lower Kent Ridge Road, Singapore 117456, Singapore.

Background: Hepatocellular carcinoma (HCC) is the cancer with the second highest mortality in the world due to its late presentation and limited treatment options. As such, there is an urgent need to identify novel biomarkers for early diagnosis and develop novel therapies. The availability of Next Generation Sequencing (NGS) data from tumors of liver cancer patients has provided us with invaluable resources to better understand HCC through the integration of data from different sources to facilitate the identification of promising biomarkers or therapeutic targets. Read More

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December 2018

Benzene Exposure Response and Risk of Myeloid Neoplasms in Chinese Workers: A Multicenter Case-Cohort Study.

J Natl Cancer Inst 2018 Dec 6. Epub 2018 Dec 6.

Nanchang Center for Disease Control and Prevention, Nanchang, China.

Background: There is international consensus that benzene exposure is causally related to acute myeloid leukemia (AML), and more recent evidence of association with myelodysplastic syndromes (MDS). However, there are uncertainties about the exposure response, particularly risks by time since exposure and age at exposure.

Methods: In a case-cohort study in 110 631 Chinese workers followed up during 1972-1999 we evaluated combined MDS/AML (n = 44) and chronic myeloid leukemia (n = 18). Read More

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December 2018
3 Reads

In silico error correction improves cfDNA mutation calling.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Medical Research Council Manchester Single Cell Research Centre, University of Manchester, Alderley Park, Manchester, UK.

Motivation: Circulating-free DNA (cfDNA) profiling by sequencing is an important minimally invasive protocol for monitoring the mutation profile of solid tumours in cancer patients. Since the concentration of available cfDNA is limited, sample library generation relies on multiple rounds of PCR amplification, during which the accumulation of errors results in reduced sensitivity and lower accuracy.

Results: We present PCR Error Correction (PEC), an algorithm to identify and correct errors in short read sequencing data. Read More

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December 2018
1 Read

MDM2 RNA In Situ Hybridization for the Diagnosis of Atypical Lipomatous Tumor: A Study Evaluating DNA, RNA, and Protein Expression.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Pathology.

The distinction of atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) from its benign counterpart, lipoma, may represent a challenge. MDM2 DNA amplification is used as the gold standard as MDM2 immunohistochemistry lacks specificity and sensitivity. Herein, we investigate the diagnostic utility of MDM2 RNA in situ hybridization (RNA-ISH) and compare the test with MDM2 immunohistochemistry and MDM2 DNA fluorescence in situ hybridization (FISH) in benign and malignant lipomatous neoplasms. Read More

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December 2018
2 Reads

Novel NTRK3 Fusions in Fibrosarcomas of Adults.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Rare Cancer Center.

NTRK fusions in malignant tumors are therapeutic targets of tyrosine kinase inhibitors. Because they occur only in a small subset of mesenchymal tumors, knowledge regarding the corresponding histology is important to effectively identify patients who could benefit from targeted therapy. In this study, using RNA sequencing, we identified novel NTRK3 fusions involving related partner genes in 2 adult bone and soft tissue tumors that met the current histologic criteria of fibrosarcoma. Read More

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December 2018
3 Reads

The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland.

Am J Surg Pathol 2018 Dec 4. Epub 2018 Dec 4.

Department of Pathology, Stanford University School of Medicine, Stanford, CA.

The spectrum of tumors arising in the salivary glands is wide and has recently been shown to harbor a network of tumor-specific fusion genes. Acinic cell carcinoma (AciCC) is one of the more frequently encountered types of salivary gland carcinoma, but it has remained a genetic orphan until recently when a fusion between the HTN3 and MSANTD3 genes was described in one case. Neither of these 2 genes is known to be implicated in any other malignancy. Read More

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December 2018

Cyclin-dependent kinase 4/6 inhibitors: what have we learnt across studies, therapy situations and substances.

Curr Opin Obstet Gynecol 2018 Dec 5. Epub 2018 Dec 5.

Department of Gynecology and Obstetrics, Regio Klinikum Pinneberg, Pinneberg, Germany.

Purpose Of Review: Cyclin-dependent kinases (CDK) are key regulatory enzymes that control cell cycle and cell division. In the recent years, new therapeutic options selectively targeting CDK 4 and 6 have shown promising clinical activity in several solid tumors. Since 2015, three CDK 4/6 inhibitors have been approved for treatment of hormone receptor-positive HER2-negative metastatic breast cancer: palbociclib, ribociclib and abemaciclib. Read More

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December 2018

Effects of High- and Low-LET Radiation on Human Hematopoietic System Reconstituted in Immunodeficient Mice.

Radiat Res 2018 Dec 6. Epub 2018 Dec 6.

a   Columbia University Medical Center, New York, New York.

Over the last 50 years, a number of important physiological changes in humans who have traveled on spaceflights have been catalogued. Of major concern are the short- and long-term radiation-induced injuries to the hematopoietic system that may be induced by high-energy galactic cosmic rays encountered on interplanetary space missions. To collect data on the effects of space radiation on the human hematopoietic system in vivo, we used a humanized mouse model. Read More

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December 2018
1 Read

Early-onset colorectal cancer in young individuals.

Mol Oncol 2018 Dec 6. Epub 2018 Dec 6.

Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, and Dipartimento di Oncologia e Emato-Oncologia, Università degli Studi di Milano (La Statale), Milan, Italy.

Treatment of young adults with colorectal cancer (CRC) represents an unmet clinical need, especially as diagnosis in this population might lead to the greatest loss of years of life. Since 1994, CRC incidence in individuals younger than 50 years has been increasing by 2% per year. The surge of CRC incidence in young adults is particularly alarming as the overall CRC frequency has been decreasing. Read More

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December 2018

Ezetimibe suppresses development of liver tumors by inhibiting angiogenesis in mice fed a high-fat diet.

Cancer Sci 2018 Dec 6. Epub 2018 Dec 6.

Division of Gastroenterology, Department of Medicine, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan, 329-0498.

Nonalcoholic steatohepatitis (NASH) is a common cause of liver cirrhosis and hepatocellular carcinoma (HCC). However, effective therapeutic strategies for preventing and treating NASH-mediated liver cirrhosis and HCC are lacking. Cholesterol is closely associated with vascular endothelial growth factor (VEGF), a key factor that promotes HCC. Read More

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December 2018

Norcantharidin inhibits proliferation and promotes apoptosis via c-Met/Akt/mTOR pathway in human osteosarcoma cells.

Cancer Sci 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopaedics, The Fourth People's Hospital of Shaanxi, Xi'an, 710043, Shaanxi, China.

Osteosarcoma (OS) is the most common malignant bone tumor that frequently affects adolescents. Norcantharidin (NCTD), a demethylated derivative of cantharidin, has been reported exhibits anticancer activity against various types of tumors except human OS. The aims of this study were to evaluate the effects of NCTD on OS cell lines (MG63 and HOS) and to explore the underlying mechanisms. Read More

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December 2018

Posttraumatic Stress Disorder and Cancer Risk: A Nested Case-Control Study.

J Trauma Stress 2018 Dec 6. Epub 2018 Dec 6.

Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Data regarding cancer risk for individuals who were exposed to traumatic and stressful life events are conflicting. We sought to evaluate the association between posttraumatic stress disorder (PTSD) and the risk of the four most common solid tumors: lung, breast, prostate, and colorectal cancers. We conducted four nested case-control studies using a large UK population-based database. Read More

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December 2018
1 Read

Dermoscopy of cutaneous smooth muscle neoplasms: a morphological study of 136 cases.

J Eur Acad Dermatol Venereol 2018 Dec 6. Epub 2018 Dec 6.

Dermatology Department. Hospital, Universitario de Alicante. ISABIAL. Miguel Hernandez University. Sant Joan de Alicante, Spain.

Background: A variety of cutaneous smooth muscle neoplasms may arise in the skin and are frequently unrecognized by clinicians. There is sparse data relating to the dermoscopy of piloleiomyiomas (PL) and nothing has been published about the dermoscopy of angioleiomyomas (AL) and leiomyosarcomas (LS).

Objectives: To evaluate the morphological findings of a large series of cutaneous PL, AL and LS under dermoscopic observation, comparing these findings among them. Read More

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December 2018
3 Reads
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