14,155 results match your criteria Tumors Orbital


[Benign Neoplasms of the Orbit].

Klin Monbl Augenheilkd 2019 Apr 18. Epub 2019 Apr 18.

Benign orbital neoplasms comprise a wide spectrum of different entities. The origin of the tumours can be epithelial or mesenchymal. Epithelial neoplasms of the orbit originate from the lacrimal gland. Read More

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http://dx.doi.org/10.1055/a-0885-2402DOI Listing

Quality-based pharmacokinetic model selection on DCE-MRI for characterizing orbital lesions.

J Magn Reson Imaging 2019 Apr 15. Epub 2019 Apr 15.

Université Paris Descartes Sorbonne Paris Cité, INSERM UMR-S970, Cardiovascular Research Center - PARCC, Paris, France.

Background: Although several studies have evaluated dynamic contrast-enhanced (DCE) MRI in the orbit, showing its utility when detecting and diagnosing orbital lesions, none have evaluated the pharmacokinetic models.

Purpose: To provide a quality-based pharmacokinetic model selection for characterizing orbital lesions using DCE-MRI at 3.0T. Read More

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http://dx.doi.org/10.1002/jmri.26747DOI Listing
April 2019
1 Read

Neurothekeoma of the eye, conjunctiva and periorbital adnexa. Report of two cases and brief review.

Surv Ophthalmol 2019 Apr 9. Epub 2019 Apr 9.

Departments of Ophthalmology and Pathology, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address:

Neurothekeomas (NTK) are benign soft tissue tumors most commonly occurring in the head, neck and upper extremities of young adults, with a female preponderance. Herein we report 2 cases of ocular NTK presenting as an orbital mass or chalazion. Both cases underwent excision of the mass with histopathologic diagnosis of cellular NTK. Read More

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http://dx.doi.org/10.1016/j.survophthal.2019.04.002DOI Listing
April 2019
1 Read

Extraskeletal Osteosarcoma: A Rare Case Arising in Phthisis Bulbi with a Review of the Literature.

Ocul Oncol Pathol 2019 Feb 26;5(2):114-118. Epub 2018 Jul 26.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.

A 60-year-old male presented with an increasingly painful and swollen phthisical eye. Enucleation revealed a large mass obliterating the eye with extension into the adjacent extraocular muscle. Histologic examination showed high-grade osteosarcoma. Read More

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https://www.karger.com/Article/FullText/487544
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http://dx.doi.org/10.1159/000487544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422128PMC
February 2019
1 Read

Periocular Histiocytoid Carcinoma: Potential Diagnostic Challenges.

Ocul Oncol Pathol 2019 Feb 5;5(2):94-101. Epub 2018 Jul 5.

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Cutaneous histiocytoid carcinoma can occur as a primary tumor of the periocular region. Morphologically similar histiocytoid carcinomas arising as primary tumors of the breast have a predilection for orbital metastases. They can occasionally contain regions with prominent vacuolated cytoplasm and minimal nuclear atypia, which mimic benign histiocytic lesions. Read More

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https://www.karger.com/Article/FullText/490250
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http://dx.doi.org/10.1159/000490250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422134PMC
February 2019
1 Read

Aggressive Ciliary Body Adenocarcinoma with Bilateral Lung Metastases: Histological, Molecular, Genetic and Clinical Aspects.

Ocul Oncol Pathol 2019 Feb 7;5(2):79-84. Epub 2018 May 7.

Sheffield Ocular Oncology Service, Department of Ophthalmology, Royal Hallamshire Hospital, Sheffield, United Kingdom.

Purpose Of The Study: To describe the clinical and histopathological features of an aggressive ciliary body adenocarcinoma with pulmonary metastases and skull base spread.

Procedures And Results: A 45-year-old female patient presented with a post-traumatic phthisical eye that was eviscerated. This showed an unexpected carcinoma (positive for cytokeratins and melanocytic markers), the histological differential diagnosis for which included a primary ciliary body adenocarcinoma or a metastasis. Read More

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http://dx.doi.org/10.1159/000487805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422130PMC
February 2019
1 Read

The practice patterns in the management of sebaceous carcinoma of the eyelid in the Asia Pacific region.

Eye (Lond) 2019 Apr 5. Epub 2019 Apr 5.

Department of Ophthalmology, Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong SAR, China.

Purpose: To determine the practice patterns of ophthalmic plastic surgeons regarding the management of eyelid sebaceous carcinoma (SC).

Methods: An electronic survey was distributed to oculoplastic surgical colleagues in the Asia Pacific region requesting clinical information and treatment approaches to SC.

Results: The responses from 192 respondents from the Asia Pacific region was included and analyzed in this study. Read More

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http://dx.doi.org/10.1038/s41433-019-0432-0DOI Listing
April 2019
1 Read

Urological manifestations of the disease related to immunoglobulin G4.

Cir Cir 2019 ;86(1):57-64

Critical Areas Division CENIAQ, Instituto Nacional de Rehabilitación. Mexico City. Mexico.

Immunoglobulin G4 related disease (IgG4-RD) is a fibro-inflammatory disease of unknown etiology, characterized by lesions in the form of tumors, elevated serum IgG4 levels, plasma cells with significant IgG4 infiltration, accompanied by phlebitis obliterans and fibrosis. This disease usually has multiorgan disease, including pancreas, biliary tract, salivary glands, peri orbital tissues, kidneys, lungs, lymph nodes and retro peritoneum. IgG4-RD mainly affects men with a predominance of age by young adults until old age. Read More

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http://dx.doi.org/10.24875/CIRUE.M18000009DOI Listing
January 2019

[Importance of interdisciplinary collaboration for optimal treatment of orbital tumors].

HNO 2019 Apr 2. Epub 2019 Apr 2.

Universitätsklinik Köln, Zentrum für Augenheilkunde, Universität zu Köln, Kerpener Straße 62, 50937, Köln, Deutschland.

Optimal treatment of tumors with orbital invasion may exceed the competences of an individual medical specialty and require interdisciplinary cooperation. The aim of this article is to present an interdisciplinary treatment concept based on the examples of intraorbital hemangioma and squamous cell carcinoma of the paranasal sinuses infiltrating the orbit. In addition to a detailed medical history and a complete ophthalmological examination, a detailed imaging technique with standardized echography and tomography methods such as orbital thin-slice CT and/or in many cases MRI is essential for the primary classification of an intraorbital pathology. Read More

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http://link.springer.com/10.1007/s00106-019-0659-x
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http://dx.doi.org/10.1007/s00106-019-0659-xDOI Listing
April 2019
5 Reads

Nonlinear adaptive control of competitive release and chemotherapeutic resistance.

Authors:
P K Newton Y Ma

Phys Rev E 2019 Feb;99(2-1):022404

Department of Physics & Astronomy, University of Southern California, Los Angeles, California 90089-1191, USA.

We use a three-component replicator system with healthy cells, sensitive cells, and resistant cells, with a prisoner's dilemma payoff matrix from evolutionary game theory, to model and control the nonlinear dynamical system governing the ecological mechanism of competitive release by which tumors develop chemotherapeutic resistance. The control method we describe is based on nonlinear trajectory design and energy transfer methods first introduced in the orbital mechanics literature for Hamiltonian systems. For continuous therapy, the basin boundaries of attraction associated with the chemo-sensitive population and the chemo-resistant population for increasing values of chemo-concentrations have an intertwined spiral structure with extreme sensitivity to changes in chemo-concentration level as well as sensitivity with respect to resistant mutations. Read More

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http://dx.doi.org/10.1103/PhysRevE.99.022404DOI Listing
February 2019

Demographics of Pediatric Orbital Lesions: A Tertiary Eye Center Experience in Saudi Arabia.

J Epidemiol Glob Health 2019 Mar;9(1):3-10

Department of Diagnostic Radiology, Mansoura Faculty Of Medicine, Egypt.

Orbital lesions vary in their classification, incidence, and presentation depending on the age and geographic distribution. Such lesions in the pediatric age group have been studied extensively because of the possibility of faster progression of orbital involvement and the higher risk of morbidity in this age group in which vision is still developing. In Saudi Arabia, orbital lesions were studied over a 6-year period in the late 1980s, when retinoblastoma cases used to present late with orbital involvement. Read More

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http://dx.doi.org/10.2991/jegh.k.181224.001DOI Listing
March 2019
1 Read

[Acute visual loss related to sphenoid meningioma].

J Fr Ophtalmol 2019 Mar 26. Epub 2019 Mar 26.

Département d'ophtalmologie, DHU vision et handicaps, hôpital Pitié-Salpêtrière, 47-92, boulevard de l'Hopital, 75013 Paris, France. Electronic address:

Meningiomas represent about 20% of intracranial tumors. Involvement of the medial sphenoid wing includes anterior clinoid, cavernous sinus and superior orbital fissure meningiomas. Due to the proximity of these tumors to the optic nerve, typically progressive unilateral vision loss, over several months to years, is the classic clinical presentation. Read More

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http://dx.doi.org/10.1016/j.jfo.2018.12.006DOI Listing
March 2019
2 Reads

Frontal Sinus Osteoma: From Direct Excision to Endoscopic Removal.

J Craniofac Surg 2019 Mar 9. Epub 2019 Mar 9.

Department of Otolaryngology, Head and Neck Surgery, Westmead Hospital.

Frontal sinus osteomas are benign bone-forming neoplasms. Ongoing advancements in endoscopic surgery have allowed less invasive surgical approaches to be adopted for removal. The authors systematically reviewed the literature to provide analysis and recommendations for management. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005371DOI Listing
March 2019
2 Reads

[Extra-nodal NK/T-cell lymphoma, nasal type presenting as orbital cellulitis].

Pan Afr Med J 2018 4;31. Epub 2018 Sep 4.

Service d'ORL et de Chirurgie Cervico-faciale, Hôpital Militaire d'Instruction Mohamed V, Faculté de Médecine, Université Mohamed V, Rabat, Maroc.

Extra-nodal NK/T-cell lymphoma, nasal type, is a rare form of malignant non-Hodgkin's lymphomas. It poses a diagnostic problem due to nonspecific symptoms. We report a case of NK/T-cell lymphoma simulating orbital cellulitis. Read More

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http://dx.doi.org/10.11604/pamj.2018.31.8.16221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6430940PMC
April 2019
2 Reads

Orbital Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma Masquerading as Pleomorphic Lipoma: A Diagnostic Challenge.

Ophthalmic Plast Reconstr Surg 2019 Mar 22. Epub 2019 Mar 22.

Department of Ophthalmology, Wills Eye Hospital, Thomas Jefferson University.

Atypical lipomatous tumor/well-differentiated liposarcoma is a common neoplasm of the superficial and deep soft tissues of the extremities, trunk, and retroperitoneum. Atypical lipomatous tumor/well-differentiated liposarcoma is very rare in the orbit, with only 19 previously reported cases. The authors describe a 22-year-old woman who presented with an 8-month history of diplopia and was found to have an orbital mass on MRI. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001378DOI Listing
March 2019
1 Read

[Oculomotor nerve neurinomas. Case reports and a literature review].

Zh Vopr Neirokhir Im N N Burdenko 2019;83(1):105-111

Burdenko Neurosurgical Institute, Moscow, Russia.

Oculomotor nerve neurinoma not associated with neurofibromatosis type II is an extremely rare pathology. According to the topography, cisternal, cisternocavernous, cavernous, orbitocavernous, and orbital tumor groups are distinguished. The clinical picture of the disease is characterized mainly by either oculomotor disorders or pyramidal symptoms, depending on the tumor localization. Read More

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http://dx.doi.org/10.17116/neiro201983011105DOI Listing
January 2019

Pneumocephalus and orbital emphysema associated with the use of an autoinflation device: a unique case report and review of the literature.

J Laryngol Otol 2019 Feb;133(2):157-160

Department of Otolaryngology,Ipswich Hospital,UK.

Background: Autoinflation devices are commonly used for otitis media with effusion and Eustachian tube dysfunction. Generally, these are very safe devices, with few or no complications.Case reportThis paper presents a case study of pneumocephalus and orbital emphysema, associated with the use of an autoinflation device, in a 73-year-old woman with Eustachian tube dysfunction and otitis media with effusion, and a history of extensive endoscopic sinus surgery 13 years previously. Read More

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http://dx.doi.org/10.1017/S0022215119000070DOI Listing
February 2019
4 Reads

Differentiation between orbital malignant and benign tumors using intravoxel incoherent motion diffusion-weighted imaging: Correlation with dynamic contrast-enhanced magnetic resonance imaging.

Medicine (Baltimore) 2019 Mar;98(12):e14897

Department of Radiology.

To evaluate the performance of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) for differentiating orbital malignant from benign tumors, and to assess the correlation between IVIM-DWI parameters and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters.Twenty-seven patients (17 benign and 10 malignant) with orbital tumors underwent 3.0T MRI examination for pre-treatment evaluation, including IVIM-DWI and DCE-MRI. Read More

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http://dx.doi.org/10.1097/MD.0000000000014897DOI Listing

Orbital Paraganglioma.

J Craniofac Surg 2019 Mar 15. Epub 2019 Mar 15.

The State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.

Background: Paragangliomas are groups of neuroendocrine neoplasms originating from neural crest cells throughout the body, but are rarely observed within the orbit.

Case Report: Two patients, a 4-year-old male and 27-year-old female, presented with a slow-growing proptosis. Well-defined masses were located in the superomedial (male) and temporal (female) portion of the right orbit and involved the entire bodies of either the superior (male) or lateral (female) rectus muscles. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005408DOI Listing
March 2019
4 Reads

Clinicopathological Review of 547 Bulbar Enucleations in Hungary (2006-2017).

J Ophthalmol 2019 14;2019:2042459. Epub 2019 Feb 14.

Department of Ophthalmology, Semmelweis University, Budapest, Hungary.

Purpose: To analyse current clinicopathological enucleation indications in a large third-referral centre in a developed country (Hungary) over a period of 12 years.

Methods: Retrospective review was performed on 547 enucleated eyes of 543 patients (48.6% males, age 52. Read More

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http://dx.doi.org/10.1155/2019/2042459DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393907PMC
February 2019
1 Read

A possible case of Erdheim-Chester Disease.

Rom J Ophthalmol 2018 Oct-Dec;62(4):308-311

University Hospital in Château-Gontier, France.

To present the case of a 57-year-old male with progressive bilateral proptosis. The patient presented with bilateral proptosis and strength deficiency on the upper limbs. During hospitalization, the progression was unfavorable; proptosis progressed, causing a severe loss of vision in the left eye (from 0. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421492PMC

SMARCB1-Deficient Sinonasal Carcinoma: A Case Report and Discussion of the Clinical Implications.

Ann Otol Rhinol Laryngol 2019 Mar 15:3489419836668. Epub 2019 Mar 15.

2 Division of Otolaryngology, University of Vermont Medical Center, Burlington, Vermont, USA.

Objective:: SMARCB1-deficient sinonasal tract carcinomas are an emerging subset of rare tumors recently described in the literature, with less than 100 reported cases. Given the aggressive nature of this tumor, timely diagnosis is especially important. We present a case report of a SMARCB1-deficient carcinoma of the sinonasal tract. Read More

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http://dx.doi.org/10.1177/0003489419836668DOI Listing

Validation Study of the AJCC Cancer Staging Manual, Eighth Edition, Staging System for Eyelid and Periocular Squamous Cell Carcinoma.

JAMA Ophthalmol 2019 Mar 14. Epub 2019 Mar 14.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston.

Importance: To our knowledge, there are no validation studies to date of the prognostic value of the AJCC Cancer Staging Manual, eighth edition (AJCC 8), criteria for eyelid and periocular squamous cell carcinoma.

Objective: To determine the association of tumor (T) category in AJCC 8 with local recurrence, nodal metastasis, distant metastasis, and disease-specific survival (DSS) for eyelid and periocular squamous cell carcinoma.

Design, Setting, And Participants: In this retrospective, single-center cohort study, 109 consecutive patients with eyelid and periocular squamous cell carcinoma treated from January 1999 to April 2018 were included. Read More

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http://dx.doi.org/10.1001/jamaophthalmol.2019.0238DOI Listing
March 2019
3 Reads

Craniofacial Approaches to Pediatric Orbital Tumors.

J Craniofac Surg 2019 Mar 6. Epub 2019 Mar 6.

Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.

Primary pediatric orbital tumors requiring surgery are uncommon and often require multidisciplinary management. Commonly used surgical approaches to the orbit include transconjunctival, transcutaneous (eyelid), transcranial, or extracranial osteotomies. This paper reviews a 10-year experience of cases that required a transcranial or extracranial surgical approach at the Birmingham Children's Hospital. Read More

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http://dx.doi.org/10.1097/SCS.0000000000005265DOI Listing
March 2019
1 Read

Predictors of Local Recurrence for Eyelid Sebaceous Carcinoma: Questionable Value of Routine Conjunctival Map Biopsies for Detection of Pagetoid Spread.

Ophthalmic Plast Reconstr Surg 2019 Mar 8. Epub 2019 Mar 8.

Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, U.S.A.

Purpose: To identify clinicopathologic factors associated with local recurrence of eyelid sebaceous carcinoma and determine whether routine conjunctival map biopsies are necessary to detect pagetoid spread.

Methods: The authors searched PubMed for articles on eyelid sebaceous carcinoma and pagetoid spread published in English during 1982 to 2018, and they reviewed 99 consecutive patients with eyelid sebaceous carcinoma who underwent surgical excision with frozen section control of margins performed by 1 author (BE) during 1999 to 2017.

Results: Local recurrence rates after surgery were 5% to 25% in the literature and 6% in the authors' cohort. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001343DOI Listing
March 2019
1 Read

Primary mucosa-associated lymphoid tissue (MALT) lymphoma of the lacrimal drainage system in two pediatric patients.

Eur J Ophthalmol 2019 Mar 12:1120672119837085. Epub 2019 Mar 12.

2 Department of Ophthalmology, Gazi University Medical School, Ankara, Turkey.

Primary non-Hodgkin lymphoma (NHL) of lacrimal drainage system (LDS) is quite rare in children, but it is important to expedite early diagnosis in an effort to alter possible life-threatening disease since they are usually misdiagnosed as chronic dacryocystitis. In the literature, there are few examples of tumors of LDS in children. The authors herein report two pediatric cases of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) originating from lacrimal sac in an attempt to increase the knowledge about the clinical course of NHL of LDS. Read More

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http://dx.doi.org/10.1177/1120672119837085DOI Listing
March 2019
1 Read

Unilateral visual loss resulting from orbital encroachment of an ethmoidal juvenile trabecular ossifying fibroma.

Ann R Coll Surg Engl 2019 Apr 11;101(4):e111-e114. Epub 2019 Mar 11.

Norwich Medical School, University of East Anglia , Norwich , UK.

Ossifying fibromas are mainly found in the mandible and maxilla. Reports of them arising in the ethmoid sinuses and orbits are rare. We present a case of an otherwise healthy 20-year-old man with gradual onset of right visual disturbance signified by right relative afferent pupillary defect due to a large unilateral ossifying fibroma arising from the ethmoid sinus compressing the medial half of the right orbit. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6432958PMC

Orbital reconstruction for tumor-associated proptosis: quantitative analysis of postoperative orbital volume and final eye position.

J Neurosurg 2019 Mar 8:1-6. Epub 2019 Mar 8.

1Department of Neurosurgery, Tufts Medical Center, Boston.

OBJECTIVESurgical resection of sphenoid wing tumors and intraorbital pathology carries the dual goal of appropriately treating the target pathology as well as correcting proptosis. Residual proptosis following surgery can lead to cosmetic and functional disability. The authors sought to quantitatively assess the effect of orbital volume before and after reconstruction to determine the optimal strategy to achieve proptosis correction. Read More

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http://dx.doi.org/10.3171/2018.12.JNS181385DOI Listing
March 2019
1 Read

Spheno-Orbital Meningioma: Surgical Outcomes and Management of Recurrence.

World Neurosurg 2019 Mar 4. Epub 2019 Mar 4.

Department of Neurosurgery, Osaka City University Graduate School of Medicine, Osaka, Japan.

Objective: Spheno-orbital meningioma (SOM) is a rare intracranial tumor that arises at the sphenoid wing, extends into the orbit, and is associated with hyperostosis of the sphenoid bone. These tumors often invade important neurovascular structures around the orbital apex, superior orbital fissure, and cavernous sinus. Aggressive tumor removal could achieve acceptable control; however, residual tumor can regrow. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.123DOI Listing
March 2019
2 Reads

Non secretory Paraganglioma in cavernous sinus masquerading as meningioma.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

Department of Neurosurgery, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, 226014, India.

Background: Paraganglioma in cavernous sinus is a rare entity often misdiagnosed as meningioma or schwanomma on radiology. The embryological origin, from cells of neural crest, does not explain location per se. Due to highly vascular nature and close proximity to carotid artery, surgical excision is a challenge. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.111DOI Listing
March 2019
2 Reads

Development of the international orbital Cavernous Hemangioma Exclusively Endonasal Resection (CHEER) staging system.

Int Forum Allergy Rhinol 2019 Feb 27. Epub 2019 Feb 27.

Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA.

Background: Orbital cavernous hemangiomas (OCH) are the most common adult orbital tumor and represent an ideal index lesion for endonasal orbital tumor surgery. In order to standardize outcomes reporting, an anatomic-based staging system was developed.

Methods: An international, multidisciplinary panel of 23 experts in orbital tumor surgery was formed. Read More

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http://doi.wiley.com/10.1002/alr.22316
Publisher Site
http://dx.doi.org/10.1002/alr.22316DOI Listing
February 2019
6 Reads

Orbital desmoplastic small round cell tumor in an infant.

Digit J Ophthalmol 2018 31;24(4):31-35. Epub 2018 Dec 31.

Florida State University College of Medicine, Tallahassee, Florida.

Desmoplastic small round cell tumor (DSRCT) is a rare, aggressive malignancy that primarily involves the serosal surfaces of the abdomen and pelvis and has a poor prognosis. Orbital involvement is extremely rare. We report the case of a 2-month-old boy who presented with a right infraorbital mass consistent with a DSRCT and causing mass effect and superonasal globe displacement. Read More

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http://www.djo.harvard.edu/site.php?url=/physicians/cr/3600
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http://dx.doi.org/10.5693/djo.02.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380253PMC
March 2019
5 Reads

Adenoid cystic carcinoma presenting with bilateral orbital extension from the soft palate.

Digit J Ophthalmol 2018 18;24(1):1-5. Epub 2018 Feb 18.

Department of Ophthalmology, Rhode Island Hospital, Providence, Rhode Island.

Adenoid cystic carcinoma (ACC) is a rare neoplasm of secretory epithelium that most commonly occurs in the fifth and sixth decades of life. It is characterized by high recurrence rates and poor response to chemotherapy, In the orbit, ACC usually presents as a lacrimal gland mass. We describe the rare case of a 70-year-old woman who presented with pain during mastication and bilateral facial numbness in the cranial nerve V2 distribution. Read More

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http://dx.doi.org/10.5693/djo.02.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380254PMC
March 2019
7 Reads

KIF15 plays a role in promoting the tumorigenicity of melanoma.

Exp Eye Res 2019 Feb 21. Epub 2019 Feb 21.

Department of Ophthalmology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, PR China; Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China. Electronic address:

Kinesins are a superfamily of motor proteins and are often dysregulated in many cancers. KIF15, which belongs to the kinesin-12 family, has been shown to function in many different cellular processes, including proliferation, apoptosis, differentiation and development. However, the role of KIF15 in melanoma, remains unknown. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00144835183061
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http://dx.doi.org/10.1016/j.exer.2019.02.014DOI Listing
February 2019
4 Reads

Iris varix: 10-year experience with 28 eyes.

Indian J Ophthalmol 2019 Mar;67(3):350-357

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, New York City, New York, USA.

Purpose: The purpose of this study is to describe the clinical characteristics, multimodality imaging findings, and clinical course of iris varices.

Methods: Retrospective, noncomparative, observational case series of 28 eyes of 26 patients with iris varices, diagnosed between 2007 and 2017, has been used.

Results: The mean (±SD) age was 58. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1253_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407407PMC
March 2019
1 Read

[Magnetic Resonance Imaging of the Orbital Cavity: Indications and Diagnostic Possibilities].

Klin Monbl Augenheilkd 2019 Mar 18;236(3):321-339. Epub 2019 Feb 18.

Today, magnetic resonance imaging (MRI) is considered the diagnostic tool of choice for eye and orbital pathologies. In this article, the MR image characteristics of relevant pathologies are illustrated with case-based examples in the context of clinical findings. Vascular pathologies (such as capillary and cavernous hemangioma), inflammatory diseases (such as endocrine orbitopathy), and neoplasms (such as lymphoma, uveal melanoma, retinoblastoma, and ocular/orbital metastasis) are described. Read More

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http://dx.doi.org/10.1055/a-0849-0000DOI Listing
March 2019
3 Reads

Neurocytoma mimicking macroadenoma.

Surg Neurol Int 2019 21;10. Epub 2019 Jan 21.

Department of Surgery and Anatomy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.

Background: Intraventricular and extraventricular central neurocytomas (CN) are equally frequent among 20-40-year-old men and women. However, sellar and suprasellar extraventricular CN are extremely rare, with only 12 reported cases.

Case Description: The authors report the case of a Brazilian 27-year-old man who presented with progressive vision loss during the last 4 years and serious bilateral keratoconus. Read More

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http://dx.doi.org/10.4103/sni.sni_387_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6357540PMC
January 2019
1 Read

Outcomes of decompressive surgery for cavernous sinus meningiomas: long-term follow-up in 50 patients.

J Neurosurg 2019 Feb 15:1-8. Epub 2019 Feb 15.

1Department of Neurosurgery, Clinical Neurosciences Center, University of Utah, Salt Lake City, Utah; and.

OBJECTIVECavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection and direct decompression of the roof and lateral wall of the cavernous sinus as well as the optic nerve. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181480DOI Listing
February 2019
1 Read

Recommendations for ultrasound examination in ophthalmology. Part II: Orbital ultrasound.

J Ultrason 2018 ;18(75):349-354

Imperial College NHS Trust, Western Eye Hospital , London , UK.

Pathological processes within the orbits are a heterogeneous group of diseases of various etiologies, clinical pictures and therapy models. Due to poor access to the orbits in a clinical examination, imaging plays a significant role in both diagnosis and treatment monitoring in patients with an orbital pathology. One of such imaging modalities is ultrasonography. Read More

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http://jultrason.pl/index.php/issues/volume-18-no-75/recomme
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http://dx.doi.org/10.15557/JoU.2018.0051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444319PMC
January 2018
5 Reads

Pseudocystic appearance of an orbital carcinoid metastasis.

Orbit 2019 Feb 12:1-4. Epub 2019 Feb 12.

a Department of Ophthalmology & Visual Sciences , University of Adelaide , Adelaide , Australia.

Carcinoid tumours are a low-grade neuroendocrine malignancy that infrequently metastisizes to orbital structures. The typical radiological appearance of carcinoid is a solid, well-circumscribed mass that enhances with contrast. We present a case of orbital carcinoid metastasis with pseudocystic radiological appearance and review of the literature. Read More

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http://dx.doi.org/10.1080/01676830.2019.1576739DOI Listing
February 2019
2 Reads

Fibroblast growth factor receptor 1 (FGFR1) as a therapeutic target in adenoid cystic carcinoma of the lacrimal gland.

Oncotarget 2019 Jan 11;10(4):480-493. Epub 2019 Jan 11.

Dr. Nasser Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Identification of molecular targets is the first step in developing efficacious therapeutic strategies for tumors. A tumors' biological response to perturbagens yields important information on the molecular determinants for tumor growth. The aim of this study was to characterize the response of adenoid cystic carcinoma of the lacrimal gland (LGACC) to intra-arterial cytoreductive chemotherapy (IACC) in order to identify novel targets to enhance therapy. Read More

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http://dx.doi.org/10.18632/oncotarget.26558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355187PMC
January 2019
1 Read

IgG4-related disease: what a hematologist needs to know.

Haematologica 2019 Mar 31;104(3):444-455. Epub 2019 Jan 31.

Division of Rheumatology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.

IgG4-related disease is a fibro-inflammatory condition that can affect nearly any organ system. Common presentations include major salivary and lacrimal gland enlargement, orbital disease, autoimmune pancreatitis, retroperitoneal fibrosis and tubulointerstitial nephritis. This review focuses on the hematologic manifestations of IgG4-related disease, including lymphadenopathy, eosinophilia, and polyclonal hypergammaglobulinemia. Read More

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http://dx.doi.org/10.3324/haematol.2018.205526DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6395313PMC
March 2019
7 Reads

[Orbital Manifestation of IgG4-Related Disease: Three Case Reports].

Klin Monbl Augenheilkd 2019 Jan 28;236(1):25-30. Epub 2019 Jan 28.

Klinik und Poliklinik für Neuroradiologie, Johannes Gutenberg-Universität Universitätsmedizin, Mainz.

IgG4-related orbital disease is rare. It belongs to an entity of a multisystemic disorder - IgG4-related disease - which has emerged recently. Differential diagnosis comprises idiopathic orbital inflammation, endocrine orbitopathy and orbital neoplasms. Read More

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http://dx.doi.org/10.1055/a-0825-6550DOI Listing
January 2019

Chemical reactivity and adsorption properties of pro-carbazine anti-cancer drug on gallium-doped nanotubes: a quantum chemical study.

J Mol Model 2019 Jan 28;25(2):46. Epub 2019 Jan 28.

Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran.

In this study, we propose new armchair single-walled nanotubes (SWNTs) for stable adsorption, increasing drug delivery performance and decreasing side effects of pro-carbazine (Pro-CB) anti-cancer in the framework of B3LYP/6-31 g*/Lanl2DZ level of theory. Indeed, doping gallium (Ga) metal in SWNTs is naturally followed by changing of geometry, increasing dipole moment, and creating one site with high reactivity in order to better adsorption of the drug molecule. Chemical reactivity descriptors show that SWNTs and Pro-CB have electrophile and nucleophile roles in interaction, respectively. Read More

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http://dx.doi.org/10.1007/s00894-018-3914-2DOI Listing
January 2019
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Malignant peripheral nerve sheath tumor of the nasal cavity and nasopharynx in a child: A case report.

Medicine (Baltimore) 2019 Jan;98(4):e14223

Department of Radiology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China.

Rationale: Malignant peripheral nerve sheath tumors (MPNSTs) are rare neoplasms with only a few reported cases affecting the nasal cavity, paranasal sinuses, and anterior skull base.

Patient Concerns: A 12-year-old girl with a mass in her nose was admitted to the Department of Otorhinolaryngology of Shenzhen Children's Hospital. She had a 4-month history of progressive, unilateral right nasal obstruction, unilateral mucopurulent rhinorrhea, foul nasal odor, snoring, hyposmia, occasional epistaxis, and no headache, no facial numbness, without eye swelling and vision loss. Read More

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http://dx.doi.org/10.1097/MD.0000000000014223DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358413PMC
January 2019
9 Reads
5.723 Impact Factor

18F-FDG PET/CT versus conventional investigations for cancer screening in autoimmune inflammatory myopathy in the era of novel myopathy classifications.

Nucl Med Commun 2019 Apr;40(4):377-382

Nuclear Medicine Department, Lady Davis Institute, Jewish General Hospital.

Background: To compare the performance of fluorine-18-fluorodeoxyglucose (F-FDG) PET/computed tomography (CT) and conventional tests for cancer screening in autoimmune inflammatory myopathy (AIM) patients.

Patients And Methods: We carried out a retrospective cohort study of AIM patients from one academic center in Montreal, Canada, classified using myositis-specific antibodies, who underwent F-FDG PET/CT between April 2005 and February 2018 and were followed up on average 3.5±2. Read More

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http://dx.doi.org/10.1097/MNM.0000000000000981DOI Listing
April 2019
7 Reads

Orbital paraganglioma in a dog.

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Dec 18;46(6):410-415. Epub 2019 Jan 18.

A 10-year-old Rottweiler presented with right-sided moderately painful exophthalmia, blindness, absence of dazzle and pupillary light reflexes, a swollen optic nerve head and ventrolateral indentation of the globe. On magnetic resonance imaging, a 3 x 2 x 2 cm mass with a fluid filled center and contrast-enhancing periphery was noted posteriolateral of the globe. Orbital ultrasound was used for a guided fine needle aspirate of the mass. Read More

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http://dx.doi.org/10.1055/s-0038-1677406DOI Listing
December 2018
6 Reads

Conjuctival lesions - the relationship of papillomas and squamous cell carcinoma to HPV infection.

Cesk Slov Oftalmol Winter 2018;74(3):92-97

The etiology of papilloma formation is multifactorial. There is a strong association between human papillomavirus (HPV) and the development of these conjunctival lesions. HPV is tumorigenic and commonly produces benign tumors with low malignant potential. Read More

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http://www.cs-ophthalmology.cz/en/journal/2018/3/2
Publisher Site
http://dx.doi.org/10.31348/2018/1/2-3-2018DOI Listing
January 2019
9 Reads