15,872 results match your criteria Tumors Orbital

Extrapulmonary Small Cell Carcinoma Presenting as an Orbital Mass: A Case Report.

Cureus 2022 Jun 16;14(6):e26012. Epub 2022 Jun 16.

Hematology and Oncology, East Orange Veterans Affairs Medical Center, East Orange, USA.

Extrapulmonary small cell carcinomas (ESCCs) are poorly differentiated neuroendocrine tumors that are characterized by an aggressive course and poor survival rates. While these tumors can be found anywhere in the body, presentations of lesions in the orbit are exceedingly rare. We present the case of a 47-year-old man who presented with blurry vision, lacrimation, and tenderness of his right eye, as well as a small but palpable temporal mass. Read More

View Article and Full-Text PDF

Hyperostosis in orbital rhabdomyosarcoma.

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Department of Ophthalmology and Visual Sciences, Philippine General Hospital, Manila, Philippines.

Rhabdomyosarcoma is the most common soft-tissue sarcoma in paediatric patients and may arise as a primary orbital neoplasm. Imaging studies show a unilateral solitary orbital lesion. With larger tumours, erosion of the adjacent orbital walls is a common accompanying bony change. Read More

View Article and Full-Text PDF

Endoscopic Endonasal Supraoptic and Infraoptic Approaches for Complex "Parasuprasellar" Lesions: Surgical Anatomy, Technique Nuances, and Case Series.

Front Oncol 2022 26;12:847250. Epub 2022 May 26.

Department of Neurosurgery, The First Affiliated Hospital of Nanchang University, Nanchang, China.

Objective: The surgical management of lesions involving the lateral area of the suprasellar region, including the lateral aspect of the planum sphenoidale and the tight junction region of the optic canal (OC), anterior clinoid process (ACP), and internal carotid artery (ICA) and its dural rings, is extremely challenging. Here, these regions, namely, the "parasuprasellar" area, are described from the endonasal perspective. Moreover, the authors introduce two novels endoscopic endonasal supraoptic (EESO) and endoscopic endonasal infraoptic (EEIO) approaches to access the parasuprasellar area. Read More

View Article and Full-Text PDF

A Rare Case of Combined Choriocarcinoma and Placental Site Trophoblastic Tumor Presenting as Skin Lesion: A Case Report.

Am J Case Rep 2022 Jun 18;23:e936451. Epub 2022 Jun 18.

Department of Internal Medicine, of Illinois College of Medicine at Peoria, Peoria, IL, USA.

BACKGROUND Despite the tendency to metastasize widely, Gestational Trophoblastic Neoplasia (GTN) is one of the most curable solid tumors with chemotherapy. CASE REPORT A 41-year-old female, G4P2A2, presented with a slowly growing lump on the left side of the scalp associated with a headache. The patient had intermittent, sharp left eye pain which radiated to the side of her face, photophobia, early morning blurring of vision, and nausea. Read More

View Article and Full-Text PDF

Orbital Rhabdomyosarcoma With Unusual Histopathology in a Young Adult.

JAMA Ophthalmol 2022 Jun 16;140(6):e221844. Epub 2022 Jun 16.

Department of Ophthalmology, Wayne & Gladys Valley Center for Vision, University of California, San Francisco, San Francisco.

View Article and Full-Text PDF

Local recurrence of uveal melanoma and concomitant brain metastases associated with an activating telomerase promoter mutation seven years after secondary enucleation.

Am J Ophthalmol Case Rep 2022 Sep 1;27:101607. Epub 2022 Jun 1.

Department of Ophthalmology and Visual Science, Yale School of Medicine, 40 Temple Street Suite 3D, New Haven, CT, 06510, USA.

Purpose: To describe a case of local recurrence of uveal melanoma with concomitant brain metastases after secondary enucleation.

Observations: A 73 year-old patient presented with dizziness and gait instability. MRI of the orbits and brain showed an anophthalmic socket with an orbital implant and an associated optic nerve mass as well as multiple mass lesions in the brain. Read More

View Article and Full-Text PDF
September 2022

Hematic Pseudocyst Masquerading as Orbital Cellulitis and Sinusitis.

Case Rep Ophthalmol 2022 Jan-Apr;13(1):265-269. Epub 2022 Apr 13.

Department of Ophthalmology, University of Colorado, Aurora, Colorado, USA.

Hematic pseudocysts are fibrous, nonepithelial lined capsules containing blood byproducts that typically present remotely following orbital fracture hardware implantation. Trauma, implant migration, and tissue erosion are believed to cause hemorrhage to pool within the capsular space. Risk factors include inadequate posterior fracture reduction and use of nonporous material which prevents fibrovascular ingrowth and stabilization. Read More

View Article and Full-Text PDF

An update on choroidal abnormalities and retinal microvascular changes in neurofibromatosis type 1.

Orphanet J Rare Dis 2022 06 13;17(1):223. Epub 2022 Jun 13.

Department of Sense Organs, Sapienza University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161, Rome, Italy.

Neurofibromatosis Type 1 (NF1) is a rare neurocutaneous disorder transmitted in an autosomal dominant fashion, mainly affecting the nervous system, the eye and skin. Ocular diagnostic hallmarks of NF1 include iris Lisch nodules, optic gliomas, orbital and eyelid neurofibromas, eyelid café-au-lait spots. In recent years, a new ocular sign represented by choroidal abnormalities (CAs) has been characterized in NF1. Read More

View Article and Full-Text PDF

Pediatric Oculo-orbital Tumor Characteristics, Imaging and Histopathology Agreement in a Tertiary Level Teaching Hospital, Ethiopia.

Ethiop J Health Sci 2022 Mar;32(2):313-320

Department of Radiology, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Oculo-orbital tumors are frequently encountered pathologies and late diagnosis results in high morbidity and mortality in developing countries. This study aims to assess the computed tomography and magnetic resonance imaging patterns of pediatric oculo-orbital tumors with particular emphasis on retinoblastoma and compare agreement between imaging and histopathology diagnosis.

Methods: A retrospective analysis of 101 pediatric patients with oculo-orbital lesions from February 2017 to January 2020 at Tikur Anbessa Specialized Hospital oncology center. Read More

View Article and Full-Text PDF

A case report of a 4-year-old girl with neurofibromatosis type 1.

Cancer Treat Res Commun 2022 Jun 2;32:100582. Epub 2022 Jun 2.

Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Ocular Disease Clinical Research Center, No 17, YongWaiZheng Street, DongHu District, Nanchang, Jiangxi, 330006, PR China. Electronic address:

Neurofibromatosis type 1 is a rare genetic disorder, which is a benign nerve tumor resulting from aberrant growth of the cells of nerve sheath. NF1 patients were associated with multisystem involvement, characterized by neurofibroma, of which 50% were associated with plexus neurofibroma. Characteristically benign plexiform neurofibromas can cause pain, disfigurement, compression and functional changes. Read More

View Article and Full-Text PDF

[Dolenc's Approach:Anterior Clinoidectomy and Extradural Approach to Cavernous Sinus].

Kentaro Mori

No Shinkei Geka 2022 May;50(3):595-604

Department of Neurosurgery, Tokyo General Hospital.

The combined epidural and subdural approach pioneered by Dolenc allows opening of the lateral wall of the cavernous sinus(CS)to treat various pathologies such as tumors and aneurysms in the cavernous, para-cavernous, and central skull base regions. The Dolenc's approach is occasionally performed with the orbitozygomatic approach(OZA), which enables us to look up highly located lesions. We prefer the two-piece method when performing OZA: it involves removing the orbitozygomatic bar separately after frontotemporal craniotomy. Read More

View Article and Full-Text PDF

A case report of inflammatory myofibroblastic tumor of cecum mimicking malignant wall thickening.

Int J Surg Case Rep 2022 May 4;94:107166. Epub 2022 May 4.

Radiology Department, CHU Hassan II Fez, Morocco; Faculty of Medicine and Pharmacy, Sidi Mohammed Ben Abdellah University, Fez, Morocco.

Introduction: Inflammatory myofibroblastic tumors (IMT) are an uncommon mesenchymal solid tumor commonly documented in children and young adults (Kim et al., 2012 [1]). Cecum is a rare location of this entity, may simulating a malignant tumor process. Read More

View Article and Full-Text PDF

Orbital osteomas associated with Gardner's syndrome: a case presentation and review of literature.

Orbit 2022 Jun 2:1-6. Epub 2022 Jun 2.

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

Gardner syndrome (GS) is a rare genetic disorder characterized by numerous intestinal colon polyps with various extraintestinal manifestations. Osteomas are a known extracolonic manifestation of GS and can affect the orbit, as seen in our patient, as well as 13 other cases documented in literature. Excision of large orbital osteomas can be successful with a multi-disciplinary approach as presented in this article. Read More

View Article and Full-Text PDF

Differentiating intradiploic orbital dermoid and epidermoid cysts utilizing clinical features and machine learning.

Indian J Ophthalmol 2022 Jun;70(6):2102-2106

Mayo Clinic, Rochester, MN, USA.

Purpose: The purpose of this study was to characterize intradiploic dermoid and epidermoid orbital cysts to determine any differences in clinical, radiographic, or surgical features.

Methods: A retrospective review was performed of patients presenting with intradiplopic dermoid or epidermoid cysts. Additionally, a complete review of the literature was performed to identify cases of intradiplopic orbital dermoid and epidermoid cysts. Read More

View Article and Full-Text PDF

Laser Treatment for Choroidal Melanoma: Current Concepts.

Surv Ophthalmol 2022 May 26. Epub 2022 May 26.

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy, The New York Eye Cancer Center, 115 East 61st Street, New York City, New York, USA, 10065.

Laser treatment has offered a relatively nonsurgical alternative for eye, life, and vision-sparing treatment of malignant melanoma of the choroid. Historically, the most commonly used forms of lasers were xenon-arc, argon laser, krypton laser, and the more recent transpupillary thermotherapy (TTT) and photodynamic therapy (PDT). Melanomas selected for laser treatment tend to be smaller and visibly accessible, which means these tumors are usually located in the posterior choroid. Read More

View Article and Full-Text PDF

Anterior Petrous Rhomboid Approach for Petroclival Chondrosarcoma.

World Neurosurg 2022 May 27. Epub 2022 May 27.

Department of Neurosurgery, All India Institute of Medical Sciences, New Delhi, India.

Access to the petroclival region has always been a matter of formidable challenge due to the surrounding neurovascular structures. The ideal approach to the region is dependent not only on the specific tumor characteristics but also on surgeon's preference. In this article, we have highlighted the use of modified Dolenc Kawase (MDK) approach to expand the standard anterior petrosectomy corridor for challenging tumors that need additional exposure. Read More

View Article and Full-Text PDF

Does reconstruction affect outcomes following exclusively endoscopic endonasal resection of benign orbital tumors: A systematic review with meta-analysis.

World J Otorhinolaryngol Head Neck Surg 2022 Mar 31;8(1):25-35. Epub 2022 Mar 31.

Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head and Neck Surgery University of Washington Seattle Washington USA.

Objective: As exclusively endoscopic endonasal resection of benign orbital tumors has become more widespread, high-quality outcomes data are lacking regarding the decision of when and how to reconstruct the medial orbital wall following resection. The goal of this study was to systematically review pertinent literature to assess clinical outcomes relative to orbital reconstruction practices.

Methods: Data Sources: PubMed, EMBASE, Web of Science. Read More

View Article and Full-Text PDF

Intracranial extension of an intramuscular haemangioma of superior rectus: case report and literature review.

BMC Ophthalmol 2022 May 23;22(1):232. Epub 2022 May 23.

Department of Ophthalmology, College of Medicine, King Saud University, P.O. Box 245, Riyadh, 11411, Saudi Arabia.

Background: Intramuscular haemangiomas are rare, benign vascular tumours that represent < 1% of all haemangiomas. When involving the extraocular muscles, haemangiomas are extremely rare, with only nine cases reported in the literature; to date there are no reported cases of extraocular muscle haemangiomas extending into the brain.

Case Presentation: A 6-year-old boy with a two-week history of a painless swelling and erythema on the upper eyelid. Read More

View Article and Full-Text PDF

Neuroblastoma: Essential genetic pathways and current therapeutic options.

Eur J Pharmacol 2022 Jul 20;926:175030. Epub 2022 May 20.

Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, 23200, Pakistan. Electronic address:

Neuroblastoma is a very diverse pediatric tumor that starts from the neural crest, and it is responsible over more than 15% of all juvenile cancer deaths. Clinical signs and symptoms are highly dependent on tumor origin and spread. Bone, lymph nodes, liver, intracranial and orbital tissues, lungs, and the central nervous system are frequently involved in metastatic neuroblastoma. Read More

View Article and Full-Text PDF

Orbital involvement in lacrimal drainage disorders.

Saudi J Ophthalmol 2021 Jul-Sep;35(3):204-208. Epub 2021 Nov 17.

Govindram Seksaria Institute of Dacryology, L.V. Prasad Eye Institute, Hyderabad, Telangana, India.

Lacrimal sac is situated anterior to the orbital septum, which acts as a barrier, thus limiting the posterior migration of the pathologies affecting the lacrimal drainage system. Certain pathologies can breach this barrier and secondarily involve the orbit causing significant clinical manifestations. This posterior migration of pathology also has a significant influence on the management and outcomes. Read More

View Article and Full-Text PDF
November 2021

Ocular adnexal lymphoma: A single-institution retrospective study.

Saudi J Ophthalmol 2021 Jul-Sep;35(3):230-238. Epub 2022 Apr 18.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: To characterize demographic, clinical, and histopathologic features of ocular adnexal lymphoma (OAL) at a single institution.

Methods: Retrospective review of all patients with pathologic diagnosis of OAL between 2015 and 2020.

Results: There were 133 patients with OAL, with a median age of 65 years (range 23-97) and a slight female predominance (male: female = 1:1. Read More

View Article and Full-Text PDF

Dual ophthalmic arteries: a new case.

Surg Radiol Anat 2022 May 22;44(5):721-725. Epub 2022 May 22.

Faculty of Medicine, Department of Radiology, Hacettepe University, 06100, Ankara, Turkey.

We report one retinoblastoma patient with dual ophthalmic arteries (also known as "double ophthalmic arteries") arising from the internal carotid artery which fuse with each other inside the orbit. The caudal ophthalmic artery with larger caliber originated from the cavernous segment of internal carotid artery and passed through the superior orbital fissure. The cranial and tiny one arose more cranially from the supraclinoid internal carotid artery and passed through the optic canal. Read More

View Article and Full-Text PDF

Cyclin D1 expression and molecular genetic findings in periocular histiocytoses and neoplasms of macrophage-dendritic cell lineage.

Am J Ophthalmol 2022 May 17. Epub 2022 May 17.

Department of Pathology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; Department of Ophthalmology, Wills Eye Hospital, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA.

Purpose: Frequent activating mutations in the mitogen-activated protein kinase (MAPK) pathway genes have been identified in histiocytoses. MAPK signaling consistently upregulates Cyclin D1. The goal of this study was to determine whether Cyclin D1 expression by immunohistochemistry is a useful diagnostic marker for periocular histiocytoses and to further characterize their genetic basis. Read More

View Article and Full-Text PDF

Congenital Conjunctival Cysts of the Orbit: Erratum.


Ophthalmic Plast Reconstr Surg 2022 May-Jun 01;38(3):309. Epub 2022 May 11.

View Article and Full-Text PDF

Navigational Transmaxillary Endoscopic Approach for Inferomedial Tumors.

Front Oncol 2022 27;12:804070. Epub 2022 Apr 27.

Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.

Orbital tumors encompass a heterogeneous range of histopathology and usually variable in location. Traditionally, transconjunctival medial orbitotomy is used to access the medial orbital wall. However, it creates potential risk of soft tissue sequelae such as scarring, lid contracture, or entropion/ectropion. Read More

View Article and Full-Text PDF

Sulfated Hyaluronan Binds to Heparanase and Blocks Its Enzymatic and Cellular Actions in Carcinoma Cells.

Int J Mol Sci 2022 May 2;23(9). Epub 2022 May 2.

Department of Biochemistry, Hoshi University School of Pharmacy, 2-4-41, Ebara, Shinagawa-ku, Tokyo 144-8501, Japan.

We examined whether sulfated hyaluronan exerts inhibitory effects on enzymatic and biological actions of heparanase, a sole endo-beta-glucuronidase implicated in cancer malignancy and inflammation. Degradation of heparan sulfate by human and mouse heparanase was inhibited by sulfated hyaluronan. In particular, high-sulfated hyaluronan modified with approximately 2. Read More

View Article and Full-Text PDF

Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.

Ophthalmic Plast Reconstr Surg 2022 May 13. Epub 2022 May 13.

Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom.

Aims: To estimate the proportion of de novo lacrimal gland pleomorphic adenomas (PAs) and carcinomas expleomorphic adenomas (CEPAs), together with age at presentation and first symptom. Conjectural models of tumor growth are considered.

Methods: Retrospective review of patients with orbital lobe PA or CEPA. Read More

View Article and Full-Text PDF

Orbital and periorbital dermoid cysts: a retrospective analysis of 270 lesions.

Orbit 2022 Jun;41(3):341-345

Department of Ophthalmology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

Purpose: To report the clinical characteristics and intraoperative findings of periorbital and orbital dermoid cysts and their relationship to location and rupture.

Methods: Retrospective review of 270 cases with orbital or periorbital dermoid cysts that presented over a period of 11 years. Patients were included if diagnosis of dermoid cyst was made by histopathologic analysis. Read More

View Article and Full-Text PDF