J Toxicol Pathol 2021 Apr 27;34(2):151-156. Epub 2021 Feb 27.
Veterinary Pharmacology and Toxicology Laboratory, Graduate School of Veterinary Sciences, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-0066, Japan.
Nickel subsulfide (NiS) is known to induce intraocular neoplasms when injected intravitreally into the eyes of rats. Here, we found two extraocular orbital neoplasms in two different rat strains, presumably due to the leakage of locally injected NiS to the extraocular orbital tissues. In the F344/DuCrlCrlj rat, an orbital mass arose at 30 weeks after injection, and invaded into the cranium. Read More