15,242 results match your criteria Tumors Orbital


Orbital neuromuscular choristoma of the ophthalmic nerve.

Eur J Ophthalmol 2021 Jun 10:11206721211024821. Epub 2021 Jun 10.

Department of Ophthalmology, Rio Hortega University Hospital, Valladolid, Spain.

Introduction: Neuromuscular choristoma (NC) is a rare tumor composed of striated muscle fibers admixed with nerve fibers that often affects large peripheral nerve trunks in children. To the best of our knowledge, this is the first reported case in the literature of a NC of the ophthalmic nerve in an adult.

Case Description: A 27-year-old woman presented with a 20-day history of left periorbital headache radiating to the frontotemporal region, with associated tearing, nausea, and vomiting. Read More

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Therapy of uveal melanoma A Review.

Cesk Slov Oftalmol 2020 ;1(Ahead of print):1-13

The aim of intraocular melanoma therapy is to achieve local tumor control, reduce the risk of metastasis development, preserve the eyeball and possibly the visual function of the eye. The choice of therapeutic approach requires a comprehensive view and individual approach to each patient with uveal melanoma. Factors considered include local finding (location, tumor size and shape, tumor activity, central visual acuity, intraocular complications), age and the patients overall physical and psychological condition, as well as the patients wishes. Read More

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A Combined Neutron and Proton Regimen for Advanced Salivary Tumors: Early Clinical Experience.

Cureus 2021 May 4;13(5):e14844. Epub 2021 May 4.

Department of Radiation Oncology, University of Washington, Seattle, USA.

Background and objective  Fast neutron radiotherapy (NRT) is a high linear energy transfer (LET) particle therapy that offers a local control (LC) advantage over low-LET X-rays in the treatment of advanced and unresectable salivary gland malignancies. However, in tumors approximating the base of skull (BOS), target volumes may be underdosed to minimize toxicity to the central nervous system (CNS). In this setting, a proton beam boost to the underdosed part of the tumor may improve LC. Read More

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Publication trends in clinical ophthalmology journals in the last decade.

Eur J Ophthalmol 2021 Jun 6:11206721211023725. Epub 2021 Jun 6.

Department of Ophthalmology, Centre Hospitalier Intercommunal de Créteil and University Paris Est, 94000 Créteil, France.

Purpose: To examine the absolute number and the proportions of articles published in general high-ranked ophthalmology journals for each ophthalmic subspecialty during the last decade, and to examine the publishing trends over the study period.

Methods: All original articles published between January 2010 and December 2019 in the selected general clinical ophthalmic journals were included in the study. All abstracts of original articles were reviewed and deemed to be related to 1 of the 11 ophthalmic subspecialties. Read More

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Locoregional Flap Reconstruction Following Oromaxillofacial Oncologic Surgery in Dogs and Cats: A Review and Decisional Algorithm.

Front Vet Sci 2021 21;8:685036. Epub 2021 May 21.

Dentistry and Oromaxillofacial Surgery Unit, Department of Surgery, ADVETIA Centre Hospitalier Vétérinaire, Vélizy-Villacoublay, France.

Primary treatment of most oromaxillofacial tumors in dogs and cats is resective surgery. Management of malignant tumors may be very challenging as wide/radical free-margin surgical removal must be achieved while preserving vital functions. Removal of orofacial tumors may result in large defects exposing the oral cavity or creating a communication with the nasal, pharyngeal, or orbital cavities. Read More

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Ipsilateral orbital metastasis following enucleation of intraocular ciliochoroidal melanoma: a rare occurrence.

BMJ Case Rep 2021 Jun 4;14(6). Epub 2021 Jun 4.

Ocular Oncology, LV Prasad Eye Institute, Hyderabad, Telangana, India

This case report demostrates an unusual occurence of orbital metastasis along with liver metastasis 5 years following enucleation for ciliochoroidal melanoma with no extraocular extension. It exemplifies that metastasis of the tumour can occur in the ipsilateral orbit after enucleation. Importance of close clinical follow-up after enucleation for choroidal melanoma, careful socket examination, and regular systemic metastatic workup is demonstrated. Read More

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Diagnostic methods and therapeutic options of uveal melanoma with emphasis on MR imaging-Part II: treatment indications and complications.

Insights Imaging 2021 Jun 4;12(1):67. Epub 2021 Jun 4.

Department of Medical Surgical Sciences and Advanced Technologies "G.F. Ingrassia" - Radiology I Unit, University Hospital Policlinico "G. Rodolico-San Marco", Via Santa Sofia, 78 - 95123, Catania, Italy.

Therapy of uveal melanoma aims to preserve the eye and its function and to avoid metastatic dissemination. The treatment choice is difficult and must keep into account several factors; the therapeutic strategy of uveal melanoma should therefore be personalized, sometimes requiring to combine different treatment techniques. Nowadays globe-sparing radiotherapy techniques are often preferred to enucleation. Read More

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Pitfalls in diagnosing orbital malignancy through orbital incisional biopsy: A report of two cases with different scenarios.

Saudi J Ophthalmol 2020 Jul-Sep;34(3):205-208. Epub 2021 Feb 27.

Department of Pathology and Laboratory Medicine, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

Several methods have been implemented to obtain suitable samples from patients for the purpose of histopathological examination and definitive diagnosis. This has been of paramount importance in dealing with oncology cases including orbital neoplasms. Open surgical biopsy has been the common standard technique used in our eye centers in Saudi Arabia for diagnosing various orbital lesions. Read More

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February 2021

Follicular lymphoma of the ocular adnexa: Clinicopathological findings with flow cytometry analysis of eight cases.

Eur J Ophthalmol 2021 Jun 3:11206721211023309. Epub 2021 Jun 3.

Department of Ophthalmology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan.

Purpose: Flow cytometry (FCM) is used to evaluate cell surface markers of various leukocyte populations quantitatively. However, little is known about the usefulness of FCM in follicular lymphoma (FL) of the ocular adnexa. The aim of this study was to evaluate the clinicopathological features and FCM results in ocular adnexal FL. Read More

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Erdheim-Chester Disease: a comprehensive review from the ophthalmologic perspective.

Surv Ophthalmol 2021 May 31. Epub 2021 May 31.

National and Kapodistrian University of Athens, 1st University Eye Clinic, G.Genimatas General Hospital, Athens, Greece. Electronic address:

Erdheim-Chester disease (ECD) is a rare clonal histiocytic neoplasm with less than 1200 documented cases to date. The disease is life-threatening and difficult to recognize, although increasing awareness as well as the integration of clinical, imaging, pathology information and genetic studies have led to a recent exponential increase in new reported cases.. Read More

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Critical review of multidisciplinary approaches for managing sinonasal tumors with orbital involvement.

Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S76-S89

Division of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Varese, Italy.

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When is a multidisciplinary surgical approach required in sinonasal tumours with cranial involvement?

Acta Otorhinolaryngol Ital 2021 Apr;41(Suppl. 1):S3-S17

Section of Otorhinolaryngology, Head and Neck Surgery, University of Padua, "Azienda Ospedaliera di Padova", Padua, Italy.

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Medulloepithelioma in newborn: Advanced clinical status.

Eur J Ophthalmol 2021 May 31:11206721211019579. Epub 2021 May 31.

Department of Medicine, Surgery and Neuroscience, Unit of Ophthalmology, OcularOncology - Retinoblastoma Referral Center, Azienda Ospedaliera Universitaria Senese, Siena, Italy.

We report three cases of congenital medulloepithelioma, which is an extremely rare clinical pattern of a tumor rare by definition. The aim of this study is to underline the clinical features of advanced medulloepithelioma in newborns. Read More

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Expression of thrombospondin-1 in conjunctival squamous cell carcinoma is correlated to the Ki67 index and associated with progression-free survival.

Graefes Arch Clin Exp Ophthalmol 2021 May 29. Epub 2021 May 29.

Department of Ophthalmology and Visual Sciences, Graduate School of Medicine, Osaka City University, 1-5-7 Asahimachi, Abeno-ku, Osaka-shi, Osaka, 545-8585, Japan.

Purpose: Conjunctival squamous cell carcinoma (SCC) is primarily treated with surgical resection. SCC has various stages, and local recurrence is common. The purpose of this study was to investigate thrombospondin-1 expression and its association with prognosis. Read More

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Distribution of skin cancers of the head and neck according to anatomical subunit.

Eur Arch Otorhinolaryngol 2021 May 28. Epub 2021 May 28.

Plastic Reconstructive and Aesthetic Surgery Department, Sivas Cumhuriyet University Medical Faculty, 58140, Sivas, Turkey.

Purpose: The skin tumors can occur on any part of the body, these anatomical subunits are considered prognostic factors for localized carcinomas. Tumor size is a prognostic criterion that also varies according to the anatomical location of these tumors. Head and neck region is the most common location. Read More

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Differences in characteristics of children with cancer who receive standard versus concurrent hospice care.

Pediatr Blood Cancer 2021 May 27:e29106. Epub 2021 May 27.

College of Nursing, University of Tennessee, Knoxville, Tennessee, USA.

Background: The provision of Section 2302 of the 2010 Patient Protection and Affordable Care Act (ACA) allowed pediatric patients who are enrolled in Medicaid to receive hospice care concurrently with curative treatment (i.e., concurrent hospice care). Read More

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Pre-and Post-Surgical Health-Related Quality of Life Evaluation of Spheno-orbital Meningioma Patients Based on EORTC QLQ-C30 Questionnaire at Dr. Cipto Mangunkusumo General Hospital.

Acta Neurol Taiwan 2020 Dec;29(4):99-102

Department of Neurosurgery, Faculty of Medicine, University of Indonesia.

Objective: Health-related quality of life (HRQoL) has become an important outcome for neurosurgical patients underwent surgery. The authors utilized the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ C-30) to assess the quality of life of spheno-orbital meningiomas patients after surgery in one national central referral hospital in Indonesia.

Methods: In this cross-sectional study, medical record-based data of 40 spheno-orbital meningioma patients who underwent surgery at Dr. Read More

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December 2020

Conjunctival melanoma: New insights in tumour genetics and immunology, leading to new therapeutic options.

Prog Retin Eye Res 2021 May 17:100971. Epub 2021 May 17.

Department of Ophthalmology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address:

Recent developments in oncology have led to a better molecular and cellular understanding of cancer, and the introduction of novel therapies. Conjunctival melanoma (CoM) is a rare but potentially devastating disease. A better understanding of CoM, leading to the development of novel therapies, is urgently needed. Read More

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Optic pathway gliosarcoma: A very rare location for a rare disease.

Radiol Case Rep 2021 Jul 30;16(7):1665-1668. Epub 2021 Apr 30.

Department of Diagnostic Imaging, Division of Neuroradiology, Universidade Federal de São Paulo (UNIFESP), SP 04024-002, Brazil.

Gliosarcoma, a variant of glioblastoma, is a rare and aggressive tumor of the central nervous system (CNS) composed of glial and sarcomatous tissues. Up to now, there are only 2 reported cases of gliosarcoma of the optical pathway. We report a case from March 2018 of a 53-year-old male patient presented with 6 months' of right fronto-orbital pulsatile headache, behavior changes, and visual loss. Read More

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NAD(P)H Quinone Oxidoreductase-1 in Organ and Tumor Tissues: Distinct Activity Levels Observed with a Benzo-rosol-Based Dual-Excitation and Dual-Emission Probe.

Anal Chem 2021 May 13;93(20):7523-7531. Epub 2021 May 13.

Department of Chemistry, Pohang University of Science and Technology, Pohang 37673, South Korea.

NAD(P)H quinone oxidoreductase-1 (NQO1), a protective enzyme against cellular oxidative stress, is expressed abnormally high in solid tumors and thus recognized as a cancer biomarker. To develop a fluorescent NQO1 probe with practicality, we investigated benzo-rosol fluorophores linked with a known self-immolative quinone substrate. Four probe candidates exhibited ratiometric sensing behavior toward the enzyme, satisfying our orbital mismatch stratagem proposed before, under dual-excitation and dual-emission conditions that alleviate the spectral overlap issue commonly observed with the ratiometric probes based on intramolecular charge-transfer change. Read More

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Isolated deep orbital hemangioma treated successfully with oral propranolol in a 2-month-old infant: Case report with literature review.

Am J Ophthalmol Case Rep 2021 Jun 16;22:101095. Epub 2021 Apr 16.

College of Medicine, QU Health, Qatar University, Doha, Qatar.

Purpose: Infantile hemangiomas (IH) are the most common benign vascular tumors of infancy. Ocular complications due to orbital IH include strabismal, deprivational, or anisometropic astigmatism, and visual loss secondary to amblyopia.

Observations: We report a case of a two-month-old female infant with a severe deep orbital IH. Read More

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Orbital metastasis from hepatocellular carcinoma revealed by sudden exophthalmos.

BMJ Case Rep 2021 May 12;14(5). Epub 2021 May 12.

Department of Neuroscience, University of Padova, Padova, Veneto, Italy.

Orbital metastases represent a rare condition and only 33 cases of metastases from hepatocellular carcinoma (HCC), usually revealed by slowly progressive exophthalmos, have been described in the literature. A 62-year-old man affected by HCC reported a sudden left exophthalmos and amaurosis. A cranial CT scan revealed pathological tissue occupying the superior portion of the orbit. Read More

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Primary Orbital Chondromyxoid Fibroma: A Cause of Monosymptomatic Periocular Pain.

Case Rep Ophthalmol 2021 Jan-Apr;12(1):193-197. Epub 2021 Apr 12.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Chondromyxoid fibroma (CMF) is a very rare entity, accounting for <1% of all bone tumours. So far, only 4 cases have been reported with the orbit as primary location. Here, we present a case of orbital CMF with periocular pain as the presenting symptom and as the only symptom when the tumour recurred after surgery. Read More

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Orbital malignant schwannoma and embryonal rhabdomyosarcoma in rats caused by leakage of locally injected nickel subsulfide to the orbit.

J Toxicol Pathol 2021 Apr 27;34(2):151-156. Epub 2021 Feb 27.

Veterinary Pharmacology and Toxicology Laboratory, Graduate School of Veterinary Sciences, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-0066, Japan.

Nickel subsulfide (NiS) is known to induce intraocular neoplasms when injected intravitreally into the eyes of rats. Here, we found two extraocular orbital neoplasms in two different rat strains, presumably due to the leakage of locally injected NiS to the extraocular orbital tissues. In the F344/DuCrlCrlj rat, an orbital mass arose at 30 weeks after injection, and invaded into the cranium. Read More

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Ectropion Uveae in neurofibromatosis type 1: a new manifestation.

Clin Ter 2021 05;172(3):206-208

Dermatologic Clinic, "Sapienza" University of Rome, Rome, Italy.

Abstract: Neurofibromatosis type 1 (NF1) is a rare genetic disorder with an autosomal dominant transmission and an estimated incidence of 1:2500-3500 live birth. Penetrance is virtually 100%, but the expression is highly variable and almost every organ can be affected. Diagnosis of NF1 is made with at least two of the following diagnostic criteria: six or more cafè-au-lait spots, two neurofibromas or one plexiform neurofibroma, axillary or groin freckling, optic glioma, two Lisch nodules, bone dysplasia and first-degree relative with NF1. Read More

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Bilateral Sinonasal Inverted Papilloma: Report of an Uncommon Case Involving Sinuses of the Face and Orbital Cavity.

Am J Case Rep 2021 May 2;22:e929910. Epub 2021 May 2.

Department of Oral Pathology, School of Dentistry, Federal University of Pará, Belém, PA, Brazil.

BACKGROUND Nasosinusal papilloma is a benign aggressive tumor. It usually occurs unilaterally in the nasal cavity and can extend to the sinuses. The diagnosis is made by the correlation of findings observed in tomographic and histopathological exams. Read More

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Adjuvant Intravitreal Bevacizumab Injection for Choroidal and Orbital Metastases of Refractory Invasive Ductal Carcinoma of the Breast.

Medicina (Kaunas) 2021 Apr 22;57(5). Epub 2021 Apr 22.

Department of Ophthalmology, Tri-Service General Hospital, National Defense Medical Center, Taipei City 11490, Taiwan.

The efficacy of combined intravitreal bevacizumab injection with systemic chemotherapy, palliative radiotherapy, and hormonal therapy to treat choroidal and orbital metastases is not known. Herein, we report the case of a 48-year-old woman with systemic chemotherapy-resistant choroidal and orbital metastases of the left eye originating from a stage IV invasive ductal carcinoma of the left breast. We describe the addition of a single intravitreal injection of bevacizumab in addition to treatment with systemic chemotherapy, hormonal therapy, and palliative radiotherapy. Read More

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Unilateral Orbital Metastasis as the Unique Symptom in the Onset of Breast Cancer in a Postmenopausal Woman: Case Report and Review of the Literature.

Diagnostics (Basel) 2021 Apr 19;11(4). Epub 2021 Apr 19.

Morphopathology Department, "Victor Babeş" University of Medicine and Pharmacy, Eftimie Murgu Sq. Nr.2, 300041 Timişoara, Romania.

The orbit represents an unusual metastases site for patients diagnosed with cancer, however, breast cancer is the main cause of metastases at this level. These orbital metastases were discovered in patients with a history of breast cancer as unique or synchronous lesions. We present a rare case of a unique retroocular metastasis as the first initial symptom of a tubulo-lobular mammary carcinoma in a postmenopausal woman. Read More

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