14,754 results match your criteria Tumors Orbital


Periorbital, conjunctival and primary intraorbital carcinomas: Survival and risk factors after orbital exenteration.

Eye (Lond) 2020 Jul 1. Epub 2020 Jul 1.

Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Kliniken-Essen-Mitte, Henricistr. 92, 45136, Essen, Germany.

Objectives: This study aimed to analyse the disease-free survival (DFS), overall survival (OS) and risk factors after orbital exenteration in patients with periorbital, conjunctival and primary intraorbital carcinomas.

Methods: Patients undergoing orbital exenteration due to a primary carcinoma between March 2000 and March 2018 were included in this retrospective study. Risk factors in all the patients were evaluated using univariate and multivariate analyses. Read More

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http://dx.doi.org/10.1038/s41433-020-1055-1DOI Listing

The Expression of IgG and IgG4 in Orbital MALT Lymphoma: The Similarities and Differences of IgG4-Related Diseases.

Onco Targets Ther 2020 17;13:5755-5761. Epub 2020 Jun 17.

Department of Ophthalmology, West China Hospital of Sichuan University, Chengdu 610000, People's Republic of China.

Objective: This study aims to study the expression and role of IgG and IgG4 in orbital MALT lymphoma and to compare the characteristics of IgG4-related diseases.

Patients And Methods: Patients with orbital MALT lymphoma, treated in the West China Hospital of Sichuan University from 2012 to 2017, were enrolled in the current study. The immunological examination of the wax blocks of orbital masses was performed again and the expression level of IgG and IgG4 in pathological tissue was analyzed. Read More

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http://dx.doi.org/10.2147/OTT.S242852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306456PMC

Endoscopic endonasal intraconal orbit surgery.

World J Otorhinolaryngol Head Neck Surg 2020 Jun 25;6(2):100-105. Epub 2019 Oct 25.

Massachusetts Eye and Ear Infirmary, Department of Otolaryngology, Harvard Medical School, Boston, MA, USA.

Endoscopic endonasal orbital surgery is evolving. With increasing knowledge, expertise, and technology, the historical limits of the endonasal endoscopic approach to the orbit have been redefined. This review discusses the clinical presentation and etiology, and highlights the pertinent anatomy, and discusses the diagnostic workup and surgical approach to orbital tumors and post-operative care. Read More

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http://dx.doi.org/10.1016/j.wjorl.2019.07.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296506PMC

A Clinicopathologic Study of Seven Cases of Orbital Solitary Fibrous Tumours.

Cureus 2020 May 24;12(5):e8259. Epub 2020 May 24.

Ophthalmology, Universiti Sains Malaysia, Kelantan, MYS.

Objective To describe the patient demographics, clinical findings, investigations, surgical outcomes, and histopathological findings of seven cases of orbital solitary fibrous tumours. Method This was a retrospective review of seven cases of orbital solitary fibrous tumour, which were followed up in Hospital Serdang, a national oculoplastic centre, from years 2008-2017. Results This study included seven patients with ages between 21 and 35 years old; two were males and five were females. Read More

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http://dx.doi.org/10.7759/cureus.8259DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7313432PMC

Primary yolk sac tumor of orbit: Report of a rare case.

Indian J Cancer 2020 Jun 22. Epub 2020 Jun 22.

Department of Pathology, Government Medical College, Nagpur, Maharashtra, India.

Extragonadal germ cell tumors (GCTs) of head and neck region account for 5% of all benign and malignant GCTs. Orbit is an uncommon site for occurrence of extragonadal GCTs. Pure yolk sac tumor (YST) of orbit is a rare neoplasm and only a few cases are reported in the literature. Read More

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http://dx.doi.org/10.4103/ijc.IJC_595_18DOI Listing

Dermoid cyst with a congenital sinus tract over the left sternoclavicular joint: a case report and literature review.

J Int Med Res 2020 Jun;48(6):300060520934984

Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, P.R. China.

Dermoid cysts are rare benign tumors that arise from ectopic epiblastic inclusions and account for 0.4% to 1.5% of all tumors. Read More

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http://dx.doi.org/10.1177/0300060520934984DOI Listing

Modified types of orbital exenteration, survival, and reconstruction.

Graefes Arch Clin Exp Ophthalmol 2020 Jun 22. Epub 2020 Jun 22.

Department of Oral and Maxillofacial Surgery, University of Duisburg-Essen, Kliniken-Essen-Mitte, Henricistr. 92, 45136, Essen, Germany.

Purpose: This study aims to analyse the various modifications of orbital exenteration.

Methods: Patients undergoing orbital exenteration from March 1978 to October 2019 were included in this retrospective study. The patients were evaluated on the basis of the indication, type of exenteration, reconstruction technique, overall survival (OS), and disease-free survival (DFS). Read More

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http://dx.doi.org/10.1007/s00417-020-04812-7DOI Listing

Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy.

Radiat Oncol 2020 Jun 22;15(1):156. Epub 2020 Jun 22.

Department of Electro-Optical Engineering, National Taipei University of Technology, 1, Sec. 3, Chung-Hsiao E. Rd, Taipei, 10608, Taiwan, ROC.

Background: The optimal treatment for lacrimal gland cancer remains unclear. Eye-preserving surgery, as opposed to exenteration, followed by adjuvant radiotherapy (RT), has recently been reported to deliver satisfactory outcomes, but evidence is sparse. The aim of the present study was to evaluate outcomes in patients with lacrimal gland cancer treated at two tertiary medical centers. Read More

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http://dx.doi.org/10.1186/s13014-020-01601-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7310012PMC

Orbital exenteration and reconstruction in a tertiary UK institution: a 5-year experience.

Orbit 2020 Jun 16:1-10. Epub 2020 Jun 16.

Guy's & St Thomas' NHS Foundation Trust, Department of ENT, Great Maze Pond , London, UK.

Purpose: Orbital exenteration is a radical oncological surgery that is usually indicated for advanced primary orbital tumors or invasion from local malignancy. We report a 5-year series from a tertiary head and neck center with particular focus on our ablative and reconstructive approach.

Methods: We performed a clinicopathological review of patients referred to Guy's and St Thomas' NHS Foundation Trust Head and Neck multidisciplinary team for management input of an orbital malignancy during the period of 2013 to 2018. Read More

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http://dx.doi.org/10.1080/01676830.2020.1775262DOI Listing

The orbitopterygoid corridor as a deep keyhole for endoscopic access to the paranasal sinuses and clivus.

J Neurosurg 2020 Jun 12:1-10. Epub 2020 Jun 12.

1Department of Neurosurgery, Lariboisière Hospital, University of Paris Diderot, Paris, France, and.

Objective: The anteromedial triangle (AMT) is the triangle formed by the ophthalmic (V1) and maxillary (V2) nerves. Opening of this bony space offers a limited access to the sphenoid sinus (SphS). This study aims to demonstrate the utility of the orbitopterygopalatine corridor (OPC), obtained by enlarging the AMT and transposing the contents of the pterygopalatine fossa (PPF) and V2, as an entrance to the SphS, maxillary sinus (MaxS), and nasal cavity. Read More

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http://dx.doi.org/10.3171/2020.3.JNS2022DOI Listing

A novel variant in GPAA1, encoding a GPI transamidase complex protein, causes inherited vascular anomalies with various phenotypes.

Hum Genet 2020 Jun 12. Epub 2020 Jun 12.

Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, Zhizaoju Road, Huangpu District, Shanghai, 200001, China.

Vascular anomalies (VAs), comprising wide subtypes of tumors and malformations, are often caused by variants in multiple tyrosine kinase (TK) receptor signaling pathways including TIE2, PIK3CA and GNAQ/11. Yet, a portion of individuals with clinical features of VA do not have variants in these genes, suggesting that there are undiscovered pathogenic factors underlying these patients and possibly with overlapping phenotypes. Here, we identified one rare non-synonymous variant (c. Read More

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http://dx.doi.org/10.1007/s00439-020-02192-wDOI Listing

Orbit Solitary Fibrous Tumor: A Proposed Risk Prediction Model Based on a Case Series and Comprehensive Literature Review.

Head Neck Pathol 2020 Jun 11. Epub 2020 Jun 11.

Department of Ophthalmology, Southern California Permanente Medical Group, Harbor City, CA, USA.

Solitary fibrous tumors (SFTs) of the orbit are rare. In order to further characterize the clinical and pathologic features of solitary fibrous tumor arising at this anatomic site, 12 cases of orbital SFTs were analyzed in conjunction with a review of 263 cases reported from the English literature in order to develop a risk prediction model. SFTs of the orbit were equally distributed between males (n = 5) and females (n = 7) with a mean patient age of 46. Read More

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http://dx.doi.org/10.1007/s12105-020-01184-6DOI Listing

A Multicenter, International Collaborative Study for AJCC-Staging of Retinoblastoma: Treatment Success and Globe Salvage.

Ophthalmology 2020 Jun 8. Epub 2020 Jun 8.

Retinoblastoma Unit, Department of Oncology, Hospital Sant Joan de Déu. Esplugues de Llobregat. Barcelona, Spain.

Purpose: To evaluate the ability of the 8 edition of the American Joint Committee on Cancer (AJCC) Staging to predict local tumor control and globe salvage for children with retinoblastoma (RB).

Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2854 eyes of 2097 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.

Methods: International, multicenter, registry-based data was pooled from patients enrolled between January 2001-December 2013. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.05.051DOI Listing

A Multicenter, International Collaborative Study for AJCC-Staging of Retinoblastoma: Metastasis-Associated Mortality.

Ophthalmology 2020 Jun 5. Epub 2020 Jun 5.

Retinoblastoma Unit, Department of Oncology, Hospital Sant Joan de Déu. Esplugues de Llobregat. Barcelona, Spain.

Purpose: To evaluate the ability of the 8 edition of the American Joint Committee on Cancer (AJCC) Cancer Staging Manual to estimate metastatic and mortality rates for children with retinoblastoma(RB).

Design: International, multicenter, registry-based retrospective case series PARTICIPANTS: 2190 patients from 18 ophthalmic oncology centers from 13 countries over 6 continents.

Methods: Patient-specific data fields for RB were designed by participating eye cancer specialists. Read More

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http://dx.doi.org/10.1016/j.ophtha.2020.05.050DOI Listing

Primary Malignant Epithelial Tumors of the Lacrimal Drainage System: A Major Review.

Orbit 2020 Jun 8:1-14. Epub 2020 Jun 8.

Govindram Sekhsaria Institute of dacryology, L.V. Prasad Eye Institute , Hyderabad, India.

Purpose: To perform a literature review on the primary malignant epithelial tumors (PMET) involving the lacrimal drainage system (LDS).

Methods: The authors performed a PubMed search of all articles published in English on primary malignant epithelial tumors of the lacrimal sac and the nasolacrimal duct. Data analyzed include prevalence, demographics, clinical presentation, histopathological subtypes, management modalities, outcomes, and recurrence rates. Read More

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http://dx.doi.org/10.1080/01676830.2020.1769684DOI Listing

Optimal indications and limitations of endoscopic transorbital superior eyelid surgery for spheno-orbital meningiomas.

J Neurosurg 2020 Jun 5:1-8. Epub 2020 Jun 5.

3Department of Neurosurgery, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Republic of Korea.

Objective: Spheno-orbital meningiomas (SOMs) are complicated tumors that involve multiple structures at initial presentation, such as the orbit, temporalis muscle, sphenoidal bone, cavernous sinus, and temporal or infratemporal fossa. The infiltrative growth and complexity of this type of meningioma make total resection impossible. In this study, the authors evaluated the surgical outcome of the endoscopic transorbital approach (eTOA) for SOM. Read More

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http://dx.doi.org/10.3171/2020.3.JNS20297DOI Listing
June 2020
3.737 Impact Factor

Carcinoid Tumors of the Orbit and Ocular Adnexa.

Ophthalmic Plast Reconstr Surg 2020 Jun 2. Epub 2020 Jun 2.

Division of Orbital and Ophthalmic Plastic Surgery and*Department of Ophthalmology, Columbia University College of Physicians and Surgeons, New York, New York.

Purpose: Well-differentiated neuroendocrine or carcinoid tumors are found most commonly in the gastrointestinal tract. When metastatic to the orbit, they tend to have a propensity for the extraocular muscles. The purpose of this study was to better understand the diversity in presentation of orbital carcinoid disease and to determine predictors for survival. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001715DOI Listing

Orbital plasmacytoma as the presenting feature in multiple myeloma.

Eur J Ophthalmol 2020 Jun 3:1120672120929959. Epub 2020 Jun 3.

The Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

A 50-year-old female patient presented with protrusion of the left eye for 1 month. Examination showed abaxial proptosis, restriction of extraocular movements, and elevated intraocular pressure. Computed tomography of the orbits showed soft tissue enhancing lesion in the superolateral aspect of the left orbit with lytic lesions in calvarium. Read More

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http://dx.doi.org/10.1177/1120672120929959DOI Listing
June 2020
1.058 Impact Factor

A case report of neonatal orbital peripheral primitive neuroectodermal tumor and literature review.

Eur J Ophthalmol 2020 Jun 3:1120672120926937. Epub 2020 Jun 3.

Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China.

Primitive neuroectodermal tumors are rare malignant neoplasms from primitive neural crest cells. Most primitive neuroectodermal tumors occur in the central and sympathetic nervous systems. We report a Chinese newborn patient presenting a huge unilateral proptosis after birth, diagnosed as orbital peripheral primitive neuroectodermal tumor by histopathology and immunohistochemistry. Read More

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http://dx.doi.org/10.1177/1120672120926937DOI Listing

Orbital solitary fibrous tumors: a multi-centered histopathological and immunohistochemical analysis with radiological description.

Ann Saudi Med 2020 May-Jun;40(3):227-233. Epub 2020 Jun 4.

From the Department of Neuroscience, School of Medicine and Surgery, University of Naples Federico II, Napoli, Campania, Italy.

Background: Solitary fibrous tumors (SFT), formerly called hemangiopericytoma, are rare tumors derived from mesenchymal cells originally described in the pleura, but these tumors may affect extraserosal tissues including the lacrimal gland and orbit.

Objective: Conduct a multi-centered clinical, radiological and histopathological analysis of 17 orbital SFT cases.

Design: A retrospective case series. Read More

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http://dx.doi.org/10.5144/0256-4947.2020.227DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270616PMC

Visual function assessed by visually evoked potentials in adults with orbital and other primary intracranial tumors.

Eur J Ophthalmol 2020 May 29:1120672120925643. Epub 2020 May 29.

Laboratório de Eletrofisiologia Visual Clínica, Departamento de Oftalmologia e Ciências Visuais, Escola Paulista de Medicina, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil.

Purpose: The purpose of this study was to assess visual function by visually evoked potentials in adults with orbital and other primary brain tumors affecting the optic pathway.

Methods: In this retrospective case-control series, patients with orbital (intraconal and extraconal) or midline/chiasmatic tumors were included. Visually evoked potentials using pattern-reversal visually evoked potential and flash visually evoked potential stimuli were performed according to the international standards. Read More

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http://dx.doi.org/10.1177/1120672120925643DOI Listing

Biportal endoscopic transorbital approach: a quantitative anatomical study and clinical application.

Acta Neurochir (Wien) 2020 May 21. Epub 2020 May 21.

Department of Neurosurgery, Brain Tumor Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Background: We devised a biportal endoscopic transorbital approach (BiETOA) to gain surgical freedom by making a port for the endoscope and investigated the benefits and limitations of BiETOA.

Methods: A cylindrical port was designed and 3-D printed using biocompatible material. The port was inserted through a keyhole between the superolateral side of the orbital rim and the temporal muscle. Read More

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http://dx.doi.org/10.1007/s00701-020-04339-0DOI Listing

Previously undiagnosed neuroendocrine tumour mimicking breast cancer metastasis to the orbit.

BMJ Case Rep 2020 May 20;13(5). Epub 2020 May 20.

Department of Ophthalmology and Vision Science, University of California Davis Health Eye Center, Sacramento, California, USA

Metastatic neuroendocrine neoplasms to the breast are rare and histopathologic overlap with mammary carcinomas has led to misdiagnosis. We present a case of a middle-aged woman with diplopia and a right medial rectus mass. Metastatic breast cancer was initially suspected based on a history of invasive ductal carcinoma. Read More

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http://dx.doi.org/10.1136/bcr-2020-234629DOI Listing

Impacted wisdom tooth in the floor of the orbit.

Indian J Dent Res 2020 Mar-Apr;31(2):312-314

Consultant, Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India.

Identification and management of ectopic supplemental tooth in anatomically complex areas such as the floor of orbit are challenging. This arises from the rarity and lack of consensus over management. The situation gets complex when there is an evidence of follicular pathology such as dentigerous cyst. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_251_20DOI Listing

Primary extramedullary plasmacytoma of the eyelid conjunctiva - A case report and review of the literature.

Ann Med Surg (Lond) 2020 Jul 7;55:1-4. Epub 2020 May 7.

Ophthalmology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

Extramedullary plasmacytomas (EMPs) are uncommon plasma cell tumors that develop in soft tissue as isolated tumors without osseous involvement while secondary lesions are associated with systemic multiple myeloma (MM). Primary extramedullary lesions are most commonly found in upper respiratory tract, gastrointestinal tract and lymph nodes. They can be found either in patients with history of MM or preceding the manifestation of a systemic disease. Read More

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http://dx.doi.org/10.1016/j.amsu.2020.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229271PMC

Posttraumatic Encapsulated Orbital Lipoma.

Mil Med 2020 May 19. Epub 2020 May 19.

Ophthalmology Department, Walter Reed National Military Medical Center, 8901 Rockville pk, Bethesda, MD 20889, USA.

A 43-year-old white male sought treatment for swelling of the left brow, which started after sustaining direct blunt trauma to the left bony orbit 6 months prior. Magnetic resonance imaging with contrast showed a 5.6 × 2. Read More

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http://dx.doi.org/10.1093/milmed/usaa080DOI Listing

Evaluation of cytology and histopathology for the diagnosis of feline orbital neoplasia: 81 cases (2004-2019) and review of the literature.

Vet Ophthalmol 2020 May 15. Epub 2020 May 15.

Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA, USA.

Objective: To provide an updated overview of feline orbital neoplasia, to compare diagnostic utility of cytology and histopathology, and to evaluate minimally invasive sampling modalities.

Procedures: A medical records search was performed to identify cats with orbital neoplasia. Data were collected regarding signalment, diagnosis, vision status, imaging modalities, and sample collection methods. Read More

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http://dx.doi.org/10.1111/vop.12776DOI Listing

[The maxillary sinus via a prelacrimal approach as a gateway to the retromaxillary space and orbital floor].

Authors:
Thomas Kühnel

HNO 2020 May 13. Epub 2020 May 13.

Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde, Universitätsklinikum Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Deutschland.

Endonasal surgery has emerged as the standard procedure for the majority of nasal and paranasal sinus pathologies. However, some pathological changes beyond the maxillary sinus seem to be out of the instrumental range and are addressed by open approaches. The prelacrimal approach to the maxillary sinus published by Zhou and coworkers has stimulated a rapid development of various procedures in this field. Read More

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http://dx.doi.org/10.1007/s00106-020-00867-4DOI Listing

Periocular basal cell carcinoma - clinical perspectives.

Oncol Rev 2020 Feb 30;14(1):420. Epub 2020 Apr 30.

Department of Ophthalmology, Faculty of Medicine, Comenius University, Bratislava, Slovakia.

Basal cell carcinoma (BCC) as a non-melanoma skin cancer type is the most common malignant tumor throughout the world. The incidence is higher in age over 60. The intense of exposure to ultraviolet radiation is one of the known risk factors. Read More

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http://dx.doi.org/10.4081/oncol.2020.420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204832PMC
February 2020

First Case of Rhinocerebral Mucormycosis Caused by Lichtheimia ornata, with a Review of Lichtheimia Infections.

Mycopathologia 2020 Jun 9;185(3):555-567. Epub 2020 May 9.

Department of Dermatology, The Affiliated Hospital, Guizhou Medical University, Beijing Road 4, Yunyan District, Guiyang, China.

Background: Lichtheimia species are emerging opportunistic fungal pathogens in the Mucorales, causing serious skin and respiratory infections in immunocompromised patients. Established agents are Lichtheimia corymbifera and L. ramosa, while L. Read More

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http://dx.doi.org/10.1007/s11046-020-00451-yDOI Listing

Etiologies of Proptosis: A review.

Intern Med Rev (Wash D C) 2020 03;6(3)

Bascom Palmer Eye, Institute, University of Miami Miller School of Medicine, Miami, FL 33136.

Proptosis, the protrusion of the eyeball from the orbit, results from a wide variety of pathologies that can be vision- or life-threatening. Clinical history, associated physical exam findings, and imaging features are all crucial in establishing the underlying etiology. The differential diagnosis is broad, and includes infectious, inflammatory, vascular, and neoplastic entities that range from benign and indolent, to malignant and aggressive. Read More

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http://dx.doi.org/10.18103/imr.v6i3.852DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204542PMC

Palpebral Pleomorphic Adenomas of the Lacrimal Gland.

Ophthalmic Plast Reconstr Surg 2020 May 4. Epub 2020 May 4.

Adnexal Service, Moorfields Eye Hospital, London, United Kingdom.

Aims: To report the characteristics and management for patients with palpebral pleomorphic adenoma of the lacrimal gland.

Methods: The records for patients with palpebral pleomorphic adenoma seen at Moorfields Eye Hospital between 1978 and 2019 were reviewed for demographics, presentation, imaging, histopathology, management, and outcome.

Results: Forty-three patients (25 male; 58%) with palpebral pleomorphic adenoma were identified, presenting at a mean age of 46 years (median 46. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001682DOI Listing

Cranio-Orbital Tumors: Clinical Results and A Surgical Approach.

Sisli Etfal Hastan Tip Bul 2019 27;53(3):240-246. Epub 2019 Aug 27.

Department of Neurosurgery, Sisli Etfal Training and Research Hospital, Istanbul, Turkey.

Objectives: In this study, we aimed to share the surgical approaches and clinical experiences of cranio-orbital tumors, which are surgically difficult anatomies.

Methods: A total of 22 orbital tumors with extraorbital-transcranial pathology between January 2004 and December 2017 were retrospectively reviewed. Information was obtained from hospital, operation and outpatient records for this study. Read More

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http://dx.doi.org/10.14744/SEMB.2018.82698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192274PMC

Orbitofrontal extensions of the insular glioma based on subdivision of the uncinate fasciculus.

J Clin Neurosci 2020 May 3. Epub 2020 May 3.

Department of Neurological Surgery and Neuroscience, University of Virginia Health System, Charlottesville, VA, USA; Department of Neurosurgery, Hacettepe University, School of Medicine, Ankara, Turkey. Electronic address:

The insular gliomas were classified based on their locations and extensions to the adjacent areas. The insular and orbitofrontal cortices with underlying fiber tracts were studied on ten (20 sides) human cadaveric brains and two heads. Twenty patients with insular gliomas with the orbitofrontal or septal region extensions were studied on preoperative magnetic resonance imaging (MRI). Read More

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http://dx.doi.org/10.1016/j.jocn.2020.04.091DOI Listing

Histopathologic spectrum of paediatric eye and ocular adnexal tumours: A 10-year review from a referral centre in Nigeria.

Niger J Clin Pract 2020 May;23(5):654-659

Department of Pathology, Faculty of Basic Clinical Sciences, College of Health Sciences, Ahmadu Bello University, Zaria, Nigeria.

Background: Tumours of the eye and adnexa demonstrate great histologic variety and constitute a serious threat to vision especially in children.

Aims: The study aims to review the epidemiologic and pathologic characteristics of tumours of the eye and ocular adnexa in the paediatric age group (0-14 years).

Methods: All the cases entered into the departmental records as tumours of the eye and ocular adnexa over a 10-year period in the age group 0-14 years were extracted. Read More

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http://dx.doi.org/10.4103/njcp.njcp_389_19DOI Listing

Differential gene methylation and expression of HOX transcription factor family in orbitofacial neurofibroma.

Acta Neuropathol Commun 2020 May 4;8(1):62. Epub 2020 May 4.

Departments of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Although most commonly benign, neurofibromas (NFs) can have devastating functional and cosmetic effects in addition to the possibility of malignant transformation. In orbitofacial neurofibromatosis type 1, NFs may cause progressive, disfiguring tumors of the lid, brow, temple, face and orbit. The purpose of this study was to identify biological differences between orbitofacial NFs and those occurring at other anatomic sites. Read More

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http://dx.doi.org/10.1186/s40478-020-00940-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197183PMC

Genetic alteration, RNA expression, and DNA methylation profiling of coronavirus disease 2019 (COVID-19) receptor ACE2 in malignancies: a pan-cancer analysis.

J Hematol Oncol 2020 05 4;13(1):43. Epub 2020 May 4.

Department of Ophthalmology, Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, 200025, People's Republic of China.

The novel coronavirus (2019-nCoV) is an emerging causative agent that was first described in late December 2019 and causes a severe respiratory infection in humans. Notably, many of affected patients of COVID-19 were people with malignancies. Moreover, cancer has been identified as an individual risk factor for COVID-19. Read More

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http://dx.doi.org/10.1186/s13045-020-00883-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7197362PMC

Ophthalmic and orbital considerations in the evaluation of skull base malignancies.

J Neurooncol 2020 May 2. Epub 2020 May 2.

Division of Neurosurgical Ophthalmology, Pacific Neuroscience Institute, 2125 Arizona Ave, Santa Monica, CA, 90404, USA.

Introduction: The orbital contents, afferent and efferent visual pathways, and the cranial nerves involved in eye movement, corneal sensation and eyelid closure traverse the skull base, a region bounded by the intracranial cavity, the paranasal sinuses, and the deep spaces of the face and head. As such, tumors from above or below have potential to affect some aspect of the visual system.

Methods: We discuss here the clinical ophthalmologic and orbital considerations in the evaluation of patients with these tumors, as well as the ophthalmic sequelae of treatment with radiation or surgery (or both). Read More

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http://dx.doi.org/10.1007/s11060-020-03516-6DOI Listing

Epithelial-Myoepithelial Carcinoma of the Lacrimal Sac and Literature Review of the Lacrimal System.

Allergy Rhinol (Providence) 2020 Jan-Dec;11:2152656720920600. Epub 2020 Apr 20.

Department of Otolaryngology-Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana.

Background: Epithelial-myoepithelial carcinomas make up less than 0.1% of head and neck malignancies and are regarded as rare, low-grade malignant neoplasms of the salivary gland. They are thought to arise from intercalated ducts with histopathology showing a classic biphasic morphology of an outer layer of myoepithelial cells and inner layer of epithelial cells. Read More

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http://dx.doi.org/10.1177/2152656720920600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175067PMC

Metastases of systemic malignancies to the orbit: a major review.

Orbit 2020 Apr 27:1-5. Epub 2020 Apr 27.

Department of Pathology, Albany Medical College, Albany, New York, USA.

: Due to improved survival durations and enhanced surveillance modalities, metastases of systemic malignancies to the orbit are increasing. This review is intended to discuss the epidemiologic, clinical, and management features of orbital metastases.: A literature search for relevant publications on the topic was performed via PubMed, and the appropriate data were extracted from these manuscripts. Read More

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http://dx.doi.org/10.1080/01676830.2020.1759110DOI Listing

Primary Orbital Dedifferentiated Liposarcoma: A Case Report.

World Neurosurg 2020 Apr 24. Epub 2020 Apr 24.

Department of Neurosurgery, Shinshu University School of Medicine, Matsumoto, Japan.

Background: Primary dedifferentiated liposarcoma of the orbit is a very rare condition.

Case Description: A 41-year-old man presented with a history of right ophthalmalgia with eye movement and exophthalmos that had developed two months earlier. Neuroimages revealed a right orbital mass located above the superior rectus muscle. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.069DOI Listing

Aseptic orbital cellulitis: A master masquerade of intraocular malignancy.

Eur J Ophthalmol 2020 Apr 22:1120672120919343. Epub 2020 Apr 22.

Department of Ophthalmology, Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Sudden and extensive growth of intraocular tumors like retinoblastoma and choroidal melanoma may result in the clinical presentation of sterile or aseptic orbital cellulitis. In such masquerading situations, ocular and orbital imaging plays a significant role. The treatment with steroids may provide a rapid recovery from the aggressive orbital inflammation. Read More

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http://dx.doi.org/10.1177/1120672120919343DOI Listing
April 2020
1.058 Impact Factor

Infantile intraorbital Ewing's sarcoma: case report and review of the literature.

Childs Nerv Syst 2020 Apr 20. Epub 2020 Apr 20.

Division of Neurosurgery, National Center for Child Health and Development, Okura 2-10-1, Setagaya-ku, Tokyo, 157-8535, Japan.

We reported a 7-month-old female with intraorbital Ewing's sarcoma. Infantile Ewing's sarcoma is rare and its prognosis is poor. Ewing's sarcoma of orbital origin is even rare. Read More

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http://dx.doi.org/10.1007/s00381-020-04606-6DOI Listing

Visual Outcomes After Endoscopic Endonasal Resection of Orbital Lesions.

World Neurosurg 2020 Apr 18. Epub 2020 Apr 18.

Division of Neurosurgery, McMaster University, Hamilton, Ontario, Canada. Electronic address:

Background: The endoscopic endonasal approach (EEA) has been increasing in popularity as an alternative to traditional transcranial and transorbital approaches in the treatment of orbital pathological entities. The purpose of the present study was to examine the outcomes of patients who had undergone EEA resection of orbital lesions at our center.

Methods: We performed a retrospective medical record review of patients who had undergone the EEA for resection of orbital lesions and orbital apex decompression from January 1, 2006 to December 1, 2019. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.050DOI Listing

CNS lymphoma, the Irish experience: A retrospective review of neuropathologically confirmed cases over 10 years.

Clin Neuropathol 2020 Apr 17. Epub 2020 Apr 17.

Background: Central nervous system (CNS) lymphoma is rare, representing 2% of all brain tumors. The commonest subtype is diffuse large B-cell lymphoma (DLBCL), with primary T-cell lymphomas (PCNSTL) accounting for ~ 2%.

Objective: To determine the frequency and describe the key features of CNS lymphoma over a 10-year period in an Irish population. Read More

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http://dx.doi.org/10.5414/NP301252DOI Listing

Orbital metastases from breast cancer: A single institution case series.

J Surg Oncol 2020 Apr 15. Epub 2020 Apr 15.

Department of Ophthalmology, Humanitas Research Hospital - IRCCS, Rozzano/Milano, Italy.

Background And Objectives: Among orbital tumors, metastatic lesions have a prevalence of 1% to 13%; on the other hand, breast cancer is the most common malignancy causing orbital metastases. The aim of this study is to present our experience dealing with orbital metastases caused by breast cancer, to assess characteristics and clinic-pathological data of patients suffering from this rare occurrence and to find indexes related with their prognosis and survival.

Methods: Records of 28 patients diagnosed with orbital metastases from breast cancer at the Department of Ophthalmology, Humanitas Clinical and Research Centre of Milano over a 27-year period (1992-2018) were retrieved and analyzed. Read More

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http://dx.doi.org/10.1002/jso.25927DOI Listing

Complex reconstruction of the orbitofrontal regions using three regional flaps after orbital exenteration for the treatment of basal cell carcinoma.

Rom J Ophthalmol 2020 Jan-Mar;64(1):57-61

Department of Plastic and Reconstructive Surgery, "Bagdasar-Arseni" Clinical Emergency Hospital, Bucharest, Romania.

The current paper presents an interesting case of facial reconstruction after the excision of a giant basal cell carcinoma located in the orbitofrontal region. Performing the excision while securing the appropriate oncologic safety margin has determined the appearance of a soft tissue defect that required a complex reconstruction using three regional flaps: frontal, temporal fascial and temporal muscle flaps. After the excision and reconstruction in a single surgical stage, the postoperative result was favorable, the 12 months assessment showing that the patient was satisfied with the aesthetic aspect. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7141915PMC

Orbital Schwannoma-Management and Clinical Outcomes.

Ophthalmic Plast Reconstr Surg 2020 Apr 9. Epub 2020 Apr 9.

Department of Ophthalmology, Royal Brisbane and Women's Hospital.

Purpose: To evaluate the clinical features, management, and outcomes of orbital schwannomas.

Methods: Retrospective study analyzing 20 orbital schwannomas in 18 patients managed in an orbital service over 26 years. Clinical, radiological, histological, and surgical procedural data were analyzed. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001657DOI Listing