4,239 results match your criteria Tularemia


The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2017.

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EFSA J 2018 Dec 12;16(12):e05500. Epub 2018 Dec 12.

This report of the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2017 in 37 European countries (28 Member States (MS) and nine non-MS). Campylobacteriosis was the commonest reported zoonosis and its EU trend for confirmed human cases increasing since 2008 stabilised during 2013-2017. The decreasing EU trend for confirmed human salmonellosis cases since 2008 ended during 2013-2017, and the proportion of human Enteritidis cases increased, mostly due to one MS starting to report serotype data. Read More

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http://dx.doi.org/10.2903/j.efsa.2018.5500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009540PMC
December 2018

The European Union summary report on trends and sources of zoonoses, zoonotic agents and food-borne outbreaks in 2016.

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EFSA J 2017 Dec 12;15(12):e05077. Epub 2017 Dec 12.

This report of the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of the zoonoses monitoring activities carried out in 2016 in 37 European countries (28 Member States (MS) and nine non-MS). Campylobacteriosis was the most commonly reported zoonosis and the increasing European Union (EU) trend for confirmed human cases since 2008 stabilised during 2012-2016. In food, the occurrence of remained high in broiler meat. Read More

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http://dx.doi.org/10.2903/j.efsa.2017.5077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7009962PMC
December 2017

The European Union One Health 2018 Zoonoses Report.

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EFSA J 2019 Dec 11;17(12):e05926. Epub 2019 Dec 11.

This report of the European Food Safety Authority and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2018 in 36 European countries (28 Member States (MS) and 8 non-MS). The first and second most commonly reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The European Union (EU) trend for confirmed human cases of these two diseases was stable during 2014-2018. Read More

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http://dx.doi.org/10.2903/j.efsa.2019.5926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7055727PMC
December 2019

Pulmonary tularaemia: a differential diagnosis to lung cancer.

ERJ Open Res 2020 Apr 29;6(2). Epub 2020 Jun 29.

Dept of Pulmonary Medicine, Oslo University Hospital, Ullevål, Norway.

Background: Pulmonary manifestations of tularaemia are reported to be infrequent in previous publications. During 2016, we noticed an increase in the number of hospitalised patients with pulmonary tularaemia in Eastern Norway. We aimed to investigate primary pulmonary tularaemia in Eastern Norway in terms of symptoms, radiological and microbiological findings, incidence and risk exposure. Read More

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http://dx.doi.org/10.1183/23120541.00093-2019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322898PMC

Disseminated Tularemia: Finding the Needle in the Haystack.

J Pediatric Infect Dis Soc 2020 Jun 14. Epub 2020 Jun 14.

Department of Pediatrics, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Read More

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http://dx.doi.org/10.1093/jpids/piaa066DOI Listing

Seroepidemiology, Spatial Distribution, and Risk Factors of in Jordan.

Am J Trop Med Hyg 2020 Jun 8. Epub 2020 Jun 8.

Department of Global and Community Health, College of Health and Human Services, George Mason University, Fairfax, Virginia.

There is a paucity of data on in the Middle East and North Africa. This is the first countrywide study to determine the seroprevalence, spatial distribution, and risk factors for in Jordan. A total of 828 Jordanians were serologically tested for . Read More

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http://dx.doi.org/10.4269/ajtmh.19-0335DOI Listing

IGF1R is an entry receptor for respiratory syncytial virus.

Nature 2020 Jun 3. Epub 2020 Jun 3.

Li Ka Shing Institute of Virology, University of Alberta, Edmonton, Alberta, Canada.

Pneumonia resulting from infection is one of the leading causes of death worldwide. Pulmonary infection by the respiratory syncytial virus (RSV) is a large burden on human health, for which there are few therapeutic options. RSV targets ciliated epithelial cells in the airways, but how viruses such as RSV interact with receptors on these cells is not understood. Read More

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http://dx.doi.org/10.1038/s41586-020-2369-7DOI Listing
June 2020
42.351 Impact Factor

You're the Flight Surgeon.

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Aerosp Med Hum Perform 2020 Apr;91(4):379-381

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http://dx.doi.org/10.3357/AMHP.5574.2020DOI Listing

A Review of Pathogens, Diseases, and Contaminants of Muskrats () in North America.

Front Vet Sci 2020 15;7:233. Epub 2020 May 15.

U.S. Geological Survey, Pennsylvania Cooperative Fish and Wildlife Research Unit, The Pennsylvania State University, University Park, PA, United States.

Over the last 50 years, significant muskrat () harvest declines have been observed throughout North America. Several theories for the decline have been proposed, including increased parasite infections and disease within muskrat populations. No existing wholistic review of muskrat exposure to pathogens, contaminants, and diseases exists. Read More

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http://dx.doi.org/10.3389/fvets.2020.00233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242561PMC

Autotransporter-Mediated Display of Complement Receptor Ligands by Gram-Negative Bacteria Increases Antibody Responses and Limits Disease Severity.

Pathogens 2020 May 14;9(5). Epub 2020 May 14.

Department of Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.

The targeting of immunogens/vaccines to specific immune cells is a promising approach for amplifying immune responses in the absence of exogenous adjuvants. However, the targeting approaches reported thus far require novel, labor-intensive reagents for each vaccine and have primarily been shown as proof-of-concept with isolated proteins and/or inactivated bacteria. We have engineered a plasmid-based, complement receptor-targeting platform that is readily applicable to live forms of multiple gram-negative bacteria, including, but not limited to, , , and . Read More

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http://dx.doi.org/10.3390/pathogens9050375DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281241PMC

Committee Opinion No. 399: Management of Tick Bites and Lyme Disease During Pregnancy.

J Obstet Gynaecol Can 2020 05;42(5):644-653

Halifax, NS.

Objective: Lyme disease is an emerging infection in Canada caused by the bacterium belonging to the Borrelia burgdorferi sensu lato species complex, which is transmitted via the bite of an infected blacklegged tick. Populations of blacklegged ticks continue to expand and are now established in different regions in Canada. It usually takes more than 24 hours of tick attachment to transfer B. Read More

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http://dx.doi.org/10.1016/j.jogc.2020.01.001DOI Listing

Epidemiologic and Epizootic Data of Tularemia in the Past and in the Recent History in Croatia.

Microorganisms 2020 May 12;8(5). Epub 2020 May 12.

Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51 000 Rijeka, Croatia.

Tularemia is a zoonotic disease caused by . A large number of recent studies have provided an update on the disease characteristics and the distribution across Europe. In Croatia, most of the clinical cases, as well as the reports of the disease in animals, date from the 20th century. Read More

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http://dx.doi.org/10.3390/microorganisms8050721DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284554PMC

[Ulceroglandular tularemia after contact with a wild boar : Risk of infection for medical personnel by aerosol inhalation during lymph node resection].

Unfallchirurg 2020 May 12. Epub 2020 May 12.

Centrum für Muskuloskeletale Chirurgie, Charité - Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin, Deutschland.

This article presents a case of ulceroglandular tularemia with local lymph node manifestation in a hobby hunter. An adequate diagnosis and early treatment of tularemia is of crucial importance not only for the patient, as when a surgical intervention is necessary there are also substantial risks for medical personnel. In the diagnosis of tularemia, which is rare but with an increasing incidence in Germany, the anamnesis provides the most important clues. Read More

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http://dx.doi.org/10.1007/s00113-020-00817-3DOI Listing

Production of Neutrophil Extracellular Traps Contributes to the Pathogenesis of tularemia.

Front Immunol 2020 24;11:679. Epub 2020 Apr 24.

College of Veterinary Medicine, Oklahoma State University, Stillwater, Oklahoma, OK, United States.

() is a highly virulent, intracellular Gram-negative bacterial pathogen. Acute infection by aerosol route causes pneumonic tularemia, characterized by nodular hemorrhagic lesions, neutrophil-predominant influx, necrotic debris, fibrin deposition, and severe alveolitis. suppresses activity of neutrophils by impairing their respiratory burst and phagocytic activity. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00679DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193117PMC

Bilateral Posterior Neck Masses in an 8-Year-Old Boy: A Case of Pediatric Tularemia of the Head and Neck.

Ear Nose Throat J 2020 May 8:145561320923830. Epub 2020 May 8.

Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University, Philadelphia, PA, USA.

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http://dx.doi.org/10.1177/0145561320923830DOI Listing

Francisella tularensis as the cause of protracted fever.

BMC Infect Dis 2020 May 7;20(1):327. Epub 2020 May 7.

Institute for Hygiene and Applied Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.

Background: Tularemia, a re-emerging, potential life threatening infectious disease, can present itself with nonspecific clinical symptoms including fever, chills and malaise. Taking a detailed history of exposure and a highly raised index of clinical suspicion are necessary to take the appropriate diagnostic and therapeutic steps in this setting. Here, a case report of typhoid tularaemia is presented. Read More

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http://dx.doi.org/10.1186/s12879-020-05051-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206669PMC

OpiA, a Type Six Secretion System Substrate, Localizes to the Cell Pole and Plays a Role in Bacterial Growth and Viability in LVS.

J Bacteriol 2020 Jun 25;202(14). Epub 2020 Jun 25.

Department of Natural Sciences and Mathematics, West Liberty University, West Liberty, West Virginia, USA

is an intracellular pathogen and the causative agent of tularemia. The type six secretion system (T6SS) is required for a number of host-pathogen interactions, including phagolysosomal escape and invasion of erythrocytes. One known effector of the T6SS, OpiA, has recently been shown to be a phosphatidylinositol-3 kinase. Read More

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http://dx.doi.org/10.1128/JB.00048-20DOI Listing

Vaccine-Mediated Mechanisms Controlling SCHU S4 Growth in a Rat Co-Culture System.

Pathogens 2020 Apr 30;9(5). Epub 2020 Apr 30.

Department of Clinical Microbiology and Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, SE-901 85 Umeå, Sweden.

causes the severe disease tularemia. In the present study, the aim was to identify correlates of protection in the rat co-culture model by investigating the immune responses using two vaccine candidates conferring distinct degrees of protection in rat and mouse models. The immune responses were characterized by use of splenocytes from naïve or Live vaccine strain- (LVS) or ∆∆-immunized Fischer 344 rats as effectors and bone marrow-derived macrophages infected with the highly virulent strain SCHU S4. Read More

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http://dx.doi.org/10.3390/pathogens9050338DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7280961PMC

[A tularemia mimicking lymphoma].

Rev Med Interne 2020 Apr 29. Epub 2020 Apr 29.

Service de médecine interne, hôpital Ambroise-Paré, 9, avenue Charles-de-Gaulle, 92100 Boulogne-Billancourt, France.

Introduction: Adenopathies are a frequent cause of recourse in internal medicine. When histological analysis reveals the presence of granuloma, multiple infectious or non-infectious etiologies are considered. If diagnoses of lymphoma, sarcoidosis or tuberculosis are easily mentioned, tularemia should also be considered in the differential diagnosis. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.03.008DOI Listing

Tickborne Diseases: Diagnosis and Management.

Am Fam Physician 2020 May;101(9):530-540

Naval Hospital Camp Pendleton Family Medicine Residency Program, Camp Pendleton, CA, USA.

Tickborne diseases that affect patients in the United States include Lyme disease, Rocky Mountain spotted fever (RMSF), ehrlichiosis, anaplasmosis, babesiosis, tularemia, Colorado tick fever, and tickborne relapsing fever. Tickborne diseases are increasing in incidence and should be suspected in patients presenting with flulike symptoms during the spring and summer months. Prompt diagnosis and treatment can prevent complications and death. Read More

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Selective Predation by Owls on Infected Bank Voles () as a Possible Sentinel of Tularemia Outbreaks.

Vector Borne Zoonotic Dis 2020 Apr 28. Epub 2020 Apr 28.

Department of Wildlife, Fish, and Environmental Studies, Swedish University of Agricultural Sciences (SLU), Umeå, Sweden.

Tularemia is a widely spread zoonotic disease in the northern hemisphere, caused by the bacterium . In humans, tularemia is an acute febrile illness with incidence peaks in late summer to early autumn of outbreak years, but there is no early warning system in place that can reduce the impact of disease by providing timely risk information. In this study, we revisit previously unpublished data on in water, sediment, soil, and small mammals from 1984 in northern Sweden. Read More

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http://dx.doi.org/10.1089/vbz.2020.2617DOI Listing

Tick-Borne Illness and Infective Endocarditis: A Rare Case of Tularemia.

CASE (Phila) 2020 Apr 21;4(2):78-81. Epub 2019 Nov 21.

Sanger Heart & Vascular Institute, Charlotte, North Carolina.

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http://dx.doi.org/10.1016/j.case.2019.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175796PMC

Biological agents of bioterrorism - preparedness is vital.

Epidemiol Mikrobiol Imunol 2020 ;69(1):42-47

Bioterrorist threats and attacks are still an issue of concern in the world. Biological agents are divided into three categories. The highest priority agents classified in category A pose a massive risk to public health and national security. Read More

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Comprehensive Laboratory Evaluation of a Specific Lateral Flow Assay for the Presumptive Identification of in Suspicious White Powders and Aerosol Samples.

Health Secur 2020 Mar/Apr;18(2):83-95

Segaran P. Pillai, PhD, is Director, Office of Laboratory Science and Safety, FDA Office of the Commissioner, Silver Spring, MD. Lindsay DePalma, MS, is a Staff Life Scientist, Booz Allen Hamilton, McLean, VA. Kristin W. Prentice, MS, is an Associate, Booz Allen Hamilton, Rockville, MD. Jason G. Ramage, MS, MBA, PMP, is Assistant Vice Chancellor for Research and Innovation and Director of Research Compliance, University of Arkansas, Fayetteville, AR. Carol Chapman, MS, is a Microbiologist, Geneva Foundation, Contractor Support to the Naval Medical Research Center, Silver Spring, MD. Jawad Sarwar, MS, is a Senior Research Scientist, and Nishanth Parameswaran is a Research Scientist; both at Omni Array Biotechnology, Rockville, MD. Jeannine Petersen, PhD, Brook Yockey, and John Young are Microbiologists; all with DHHS/CDC/OID/NCEZID/DVBD/BDB, Fort Collins, CO. Ajay Singh, PhD, is a Research Scientist, Laulima Government Solutions, Contractor Support to USAMRICD, Neurobiological Toxicology Branch, Analytical Toxicology Division, Aberdeen Proving Ground, MD. Christine A. Pillai and Gowri Manickam, PhD, are ORISE Fellow Research Scientists; Nagarajan Thirunavvukarasu, PhD, is an ORISE Fellow; and Shashi K. Sharma, PhD, is a Research Microbiologist; all at the FDA Center for Food Safety and Applied Nutrition, Molecular Methods Development Branch, Division of Microbiology, Office of Regulatory Science, College Park, MD. Julie R. Avila, MS, is a Scientific Associate, Lawrence Livermore National Laboratory, Biosciences and Biotechnology Division, Livermore, CA. Stephen A. Morse, MSPH, PhD, is a Senior Advisor, CDC Division of Select Agents and Toxins, and is currently with IHRC, Inc., Atlanta, GA. Kodumudi Venkateswaran, PhD, is Chief Scientist, Tetracore, Inc., Rockville, MD. Kevin Anderson, PhD, and David R. Hodge, PhD, are Program Managers, Science and Technology Directorate, US Department of Homeland Security, Washington, DC.

We conducted a comprehensive, multi-phase laboratory evaluation of the Tularemia BioThreat Alert (BTA) test, a lateral flow assay (LFA) for the rapid detection of . The study, conducted at 2 sites, evaluated the limit of detection (LOD) of this assay using the virulent SchuS4 strain and the avirulent LVS strain of . In 6-phase evaluation (linear dynamic range and reproducibility, inclusivity, near-neighbor, environmental background, white powder, and environmental filter extract), 13 diverse strains of , 8 near neighbors, 61 environmental background organisms, 26 white powders, and a pooled aerosol extract were tested. Read More

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http://dx.doi.org/10.1089/hs.2019.0151DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194312PMC

[A severely ill 33-year-old woman with hepatic abscesses].

Authors:
T Bächle J Andree

Internist (Berl) 2020 May;61(5):518-521

Klinik für Innere Medizin, Gastroenterologie, Hämato-Onkologie, Pneumologie und Palliativmedizin, Krankenhaus Bietigheim-Vaihingen, Riedstr. 12, 74321, Bietigheim-Bissingen, Deutschland.

A 33-year-old woman in a seriously ill state presented with hepatic abscesses. The proof of epitheloid-like reactions by biopsy and further serological analysis led to the final diagnosis of tularemia, which represents a rare disease in Germany. Thereafter targeted antibiotic therapy was successfully initiated. Read More

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http://dx.doi.org/10.1007/s00108-020-00783-3DOI Listing

PCR Based Prevalence Study of in Kharkiv, Dnipropetrovsk, and Mykolaiv Oblasts during 2015-2018.

J Vet Res 2020 Mar 31;64(1):63-71. Epub 2020 Jan 31.

Department of Molecular Epizootology and Diagnostics, National Scientific Center Institute of Experimental and Clinical Veterinary Medicine of the NAAS of Ukraine, 61023 Kharkiv, Ukraine.

Introduction: Tularaemia is a zoonotic disease caused by the gram-negative bacterium , which is endemic to Ukraine. The aim of this work was to provide screening of different field samples (rodent tails, ticks, pellets, water, and hay) to obtain an actual picture of the tularaemia epizootic situation in the Kharkiv, Dnipropetrovsk, and Mykolaiv oblasts.

Material And Methods: Samples were collected using the flag method (for ticks) and break-back traps (for rodents). Read More

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http://dx.doi.org/10.2478/jvetres-2020-0007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105997PMC

Genomic profiling of Nipah virus using NGS driven RNA-Seq expression data.

Bioinformation 2019 31;15(12):853-862. Epub 2019 Dec 31.

Institute of Bangladesh Studies, University of Rajshahi, Rajshahi, Bangladesh.

Nipah virus (NiV) is an ssRNA, enveloped paramyxovirus in the genus Henipaveridae with a case fatality rate >70%. We analyzed the NGS RNA-Seq gene expression data of NiV to detect differentially expressed genes (DEGs) using the statistical R package limma. We used the Cytoscape, Ensembl, and STRING tools to construct the gene-gene interaction tree, phylogenetic gene tree and protein-protein interaction networks towards functional annotation. Read More

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http://dx.doi.org/10.6026/97320630015853DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7088422PMC
December 2019

Characterization of Schu S4 mutants as live attenuated tularemia vaccine candidates.

Virulence 2020 12;11(1):283-294

Center for Vaccine Development, University of Maryland Baltimore, Baltimore, MD, USA.

There is a need for development of an effective vaccine against , as this potential bioweapon has a high mortality rate and low infectious dose when delivered via the aerosol route. Moreover, this Tier 1 agent has a history of weaponization. We engineered targeted mutations in the Type A strain subspecies Schu S4 in genes encoding critical enzymes in aromatic amino acid biosynthesis. Read More

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http://dx.doi.org/10.1080/21505594.2020.1746557DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161688PMC
December 2020

Early detection of viable Francisella tularensis in environmental matrices by culture-based PCR.

BMC Microbiol 2020 Mar 25;20(1):66. Epub 2020 Mar 25.

US EPA, Office of Research and Development, Center for Environmental Solutions & Emergency Response, 26 W Martin Luther King Drive NG-16, Cincinnati, OH, 45268, USA.

Background: Francisella tularensis is a fastidious, Gram-negative coccobacillus and is the causative agent of tularemia. To assess viability yet overcome lengthy incubation periods, a culture-based PCR method was used to detect early growth of the lowest possible number of F. tularensis cells. Read More

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http://dx.doi.org/10.1186/s12866-020-01748-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7093956PMC

Brief outcome of five decades of battle with infectious diseases in Iran.

Virusdisease 2020 Mar 23;31(1):10-12. Epub 2020 Jan 23.

4Department of Microbiology, Faculty of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

According to WHO health profile, Iran has better situation in controlling some infection disease like leprosy, dengue fever, tularemia and hepatitis B than United States, even though Iran is in a more dangerous area than the USA. Achieving optimum control for infectious disease in the Middle East requires huge financial costs, equipment and a great time. Some of Iran's actions to control infectious diseases include: special attention of the Iran government to the health issue, training and developing human resources, membership and close cooperation with international organizations like WHO, detecting and monitoring emerging diseases before their arrival and distribution in Iran, expanding and updating national immunization and vaccination program since 1992, national project implementation titled "Health system development plan", supplying and manufacturing most of drugs required in Iran by the Iranian companies as a strategic planning, great coordination between different departments of the MOHME and other relevant institutions to Iran Army and Ministry of Intelligence to prevent the emergence of bioterrorism, and etc. Read More

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http://dx.doi.org/10.1007/s13337-019-00565-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7085491PMC

Phylogeography and Genetic Diversity of subsp. in France (1947-2018).

Front Microbiol 2020 4;11:287. Epub 2020 Mar 4.

Paris-Est University/ANSES, Animal Health Laboratory, Maisons-Alfort, France.

In France, tularemia is caused by subsp. and is a sporadic disease affecting mainly wildlife animals and humans. species presents low genetic diversity that remains poorly described in France, as only a few genomes of isolates from the country are available so far. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064806PMC
March 2020
3.941 Impact Factor

Ecology and Epidemiology of Tickborne Pathogens, Washington, USA, 2011-2016.

Emerg Infect Dis 2020 Apr;26(4):648-657

Tickborne diseases are rare in Washington, USA, and the ecology of these pathogens is poorly understood. We integrated surveillance data from humans and ticks to better describe their epidemiology and ecology. During 2011-2016, a total of 202 tickborne disease cases were reported in Washington residents. Read More

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http://dx.doi.org/10.3201/eid2604.191382DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101130PMC
April 2020
6.751 Impact Factor

XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia.

Structure 2020 05 5;28(5):540-547.e3. Epub 2020 Mar 5.

Center for Applied Structural Discovery, the Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA; School of Molecular Sciences, Arizona State University, Tempe, AZ 85287, USA. Electronic address:

Francisella tularensis is the causative agent for the potentially fatal disease tularemia. The lipoprotein Flpp3 has been identified as a virulence determinant of tularemia with no sequence homology outside the Francisella genus. We report a room temperature structure of Flpp3 determined by serial femtosecond crystallography that exists in a significantly different conformation than previously described by the NMR-determined structure. Read More

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http://dx.doi.org/10.1016/j.str.2020.02.005DOI Listing

Optimisation of External Factors for the Growth of within .

Biomed Res Int 2020 20;2020:6826983. Epub 2020 Jan 20.

Department of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.

The amoeba has been used as a model organism to study host-pathogen interaction in many intracellular bacteria. is a Gram-negative, highly infectious bacterium that causes the zoonotic disease tularemia. The bacterium is able to replicate in different phagocytic and nonphagocytic cells including mammalian, amoebae, and arthropod cells. Read More

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http://dx.doi.org/10.1155/2020/6826983DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6996686PMC
January 2020

Wild Rodents and Their Ectoparasites in an Enzootic Plague Focus, Western Iran.

Vector Borne Zoonotic Dis 2020 May 20;20(5):334-347. Epub 2020 Feb 20.

National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.

Entomological surveys of ectoparasites and their hosts are an essential tool for assessing the risks of rodent-borne diseases transmitted to humans by arthropod vectors. This study was carried out to update the epidemiological data of plague with respect to species compositions of the rodents and their ectoparasites at enzootic foci located in Kurdistan Province, Iran. The rodents' habitats were selected based on past records of plague and subclimates in each study district with especial attention to the vegetation type. Read More

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http://dx.doi.org/10.1089/vbz.2019.2524DOI Listing
May 2020
2.298 Impact Factor

Autogeny in Culiseta longiareolata (Culicidae: Diptera) mosquitoes in laboratory conditions in Iran.

BMC Res Notes 2020 Feb 19;13(1):81. Epub 2020 Feb 19.

Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.

Objectives: Culiseta longiareolata is a cosmopolitan species and has implicated in the transmission of avian malaria, tularemia, and arboviruses. Despite the wide distribution of Cs. longiareolata in Iran, little is known about its biology and physiology. Read More

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http://dx.doi.org/10.1186/s13104-020-04942-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031961PMC
February 2020

Proteome Wide Profiling of -ε-Lysine Acetylation Reveals a Novel Mechanism of Regulation of the Chitinase Activity in .

J Proteome Res 2020 Apr 4;19(4):1409-1422. Epub 2020 Mar 4.

School of Systems Biology, George Mason University, 10900 University Blvd, Manassas, Virginia 20110, United States.

is a Gram-negative bacterium that causes the zoonotic disease tularemia. The historical development of tularemia as a biological weapon has led to it being characterized by the CDC as a category A biothreat agent. Neither posttranslational modification (PTM) of proteins, in particular lysine acetylation, in nor its subsequent regulation of the protein activity has been well studied. Read More

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http://dx.doi.org/10.1021/acs.jproteome.9b00512DOI Listing

The Francisella tularensis Polysaccharides: What Is the Real Capsule?

Microbiol Mol Biol Rev 2020 May 12;84(1). Epub 2020 Feb 12.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, USA

SUMMARY is a tier 1 select agent responsible for tularemia in humans and a wide variety of animal species. Extensive research into understanding the virulence factors of the bacterium has been ongoing to develop an efficacious vaccine. At least two such virulence factors are described as capsules of : the O-antigen capsule and the capsule-like complex (CLC). Read More

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http://dx.doi.org/10.1128/MMBR.00065-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7018499PMC

[Determination of the Subspecies of Francisella tularensis Isolated in Turkey by Molecular Methods].

Mikrobiyol Bul 2020 Jan;54(1):1-10

Yıldırım Beyazıt University Faculty of Medicine, Department of Medical Microbiology, Ankara, Turkey.

Francisella tularensis is a gram-negative, coccobasillus, facultative intracellular bacteria and causes a zoonotic disease, tularemia in humans. F.tularensis has four subspecies, which have different virulences for humans as F. Read More

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http://dx.doi.org/10.5578/mb.68784DOI Listing
January 2020

Combinations of early generation antibiotics and antimicrobial peptides are effective against a broad spectrum of bacterial biothreat agents.

Microb Pathog 2020 Feb 9;142:104050. Epub 2020 Feb 9.

Bacteriology Division, United States Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Frederick, MD, 21702-5011, USA. Electronic address:

The misuse of infectious disease pathogens as agents of deliberate attack on civilians and military personnel is a serious national security concern, which is exacerbated by the emergence of natural or genetically engineered multidrug resistant strains. In this study, the therapeutic potential of combinations of an antibiotic and a broad-spectrum antimicrobial peptide (AMP) was evaluated against five bacterial biothreats, the etiologic agents of glanders (Burkholderia mallei), melioidosis (Burkholderia pseudomallei), plague (Yersinia pestis), tularemia (Francisella tularensis), and anthrax (Bacillus anthracis). The therapeutics included licensed early generation antibiotics which are now rarely used. Read More

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http://dx.doi.org/10.1016/j.micpath.2020.104050DOI Listing
February 2020

Francisella novicida and F. philomiragia biofilm features conditionning fitness in spring water and in presence of antibiotics.

PLoS One 2020 5;15(2):e0228591. Epub 2020 Feb 5.

TIMC-IMAG UMR 5525-UGA CNRS, Grenoble Cedex 9, France.

Biofilms are currently considered as a predominant lifestyle of many bacteria in nature. While they promote survival of microbes, biofilms also potentially increase the threats to animal and public health in case of pathogenic species. They not only facilitate bacteria transmission and persistence, but also promote spreading of antibiotic resistance leading to chronic infections. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228591PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001994PMC

Lack of Tularemia Among Health Care Providers With Close Contact With Infected Patients-A Case Series.

Open Forum Infect Dis 2020 Jan 19;7(1):ofz499. Epub 2019 Nov 19.

Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Jamaica Plain, Massachusetts, USA.

has a low infectious dose and can infect laboratory staff handling clinical specimens. The risk to health care providers exposed during patient care is poorly defined. We describe 9 examples of health care providers who did not develop tularemia after significant exposures to infected patients. Read More

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http://dx.doi.org/10.1093/ofid/ofz499DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6989715PMC
January 2020

A Rare Cause of Prosthetic Valve Infective Endocarditis: .

WMJ 2019 Dec;118(4):196-198

Department of Medicine, Division of Infectious Diseases, Medical College of Wisconsin, Zablocki VA Medical Center, Milwaukee, Wisconsin,

Introduction: subspecies is the most common cause of tularemia in Europe and Japan. Tularemia presents in clinical syndromes, usually as ulceroglandular and glandular syndrome. This entity rarely causes endocarditis. Read More

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December 2019

Surveillance of Francisella tularensis in surface water of Kurdistan province, west of Iran.

Comp Immunol Microbiol Infect Dis 2020 Apr 8;69:101419. Epub 2020 Jan 8.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar-Ahang, Hamadan, Iran; Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: The etiologic agent of tularemia, Francisella tularensis, is transmitted to humans via ingestion of contaminated water or food, arthropods bite, respiratory aerosols, or direct contact with infected animals body fluids or tissues. In the current study, due to the importance of water in transmitting the disease and the report of the disease in different regions of Iran, surface water of Kurdistan province were evaluated for the presence of F.tularensis. Read More

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http://dx.doi.org/10.1016/j.cimid.2020.101419DOI Listing
April 2020
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Causes of Mortality and Disease in Rabbits and Hares: A Retrospective Study.

Animals (Basel) 2020 Jan 17;10(1). Epub 2020 Jan 17.

Departamento de Sanidad Animal, Facultad de Veterinaria, Campus de Vegazana s/n, Universidad de León, 24071 León, Spain.

In this study we determined the causes of mortality and disease in a total of 325 lagomorphs (rabbits and hares) in northern Spain between 2000 and 2018. Risk factors such as the species, age, sex, time of year and origin were also considered. Clinical signs, gross and histopathological findings and ancillary test results were the basis for the final diagnoses that were reviewed to classify and identify the different disorders. Read More

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http://dx.doi.org/10.3390/ani10010158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7022519PMC
January 2020

Differentiation of Francisella tularensis Subspecies and Subtypes.

J Clin Microbiol 2020 Mar 25;58(4). Epub 2020 Mar 25.

Air Force Research Laboratory, Applied Technology and Genomics Division, Wright-Patterson Air Force Base, Ohio, USA.

The highly infectious and zoonotic pathogen is the etiologic agent of tularemia, a potentially fatal disease if untreated. Despite the high average nucleotide identity, which is >99.2% for the virulent subspecies and >98% for all four subspecies, including the opportunistic microbe subsp. Read More

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http://dx.doi.org/10.1128/JCM.01495-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098747PMC

A rare cause of granulomatous hepatitis: Tularemia.

J Infect Public Health 2020 Jul 11;13(7):1003-1005. Epub 2020 Jan 11.

Çukurova University Faculty of Medicine, Departman of Radiology. Adana, Turkey. Electronic address:

Tularemia is a zoonotic infection caused by Francisella tularensis. Tularemia has several clinical form in humans, including ulceroglandular, pneumonic, oropharyngeal, oculoglandular, and systemic (typhoidal). Tularemia may develop granulomatous and suppurative lesions, especially in the affected regional lymph nodes and various organs. Read More

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http://dx.doi.org/10.1016/j.jiph.2019.12.007DOI Listing

infection in dogs: 88 cases (2014-2016).

J Am Vet Med Assoc 2020 01;256(2):220-225

Objective: To characterize the epidemiology, clinical signs, and treatment of dogs with infection in New Mexico.

Animals: 87 dogs in which 88 cases of tularemia (1 dog had 2 distinct cases) were confirmed by the New Mexico Department of Health Scientific Laboratory Division from 2014 through 2016 and for which medical records were available.

Procedures: Dogs were confirmed to have tularemia if they had a 4-fold or greater increase in anti- antibody titer between acute and convalescent serum samples or had been isolated from a clinical or necropsy specimen. Read More

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http://dx.doi.org/10.2460/javma.256.2.220DOI Listing
January 2020