4,354 results match your criteria Tularemia

Development of an immunoassay test system based on monoclonal antybodies and immunomagnetic particles for the detection of F. tularensis cells.

Klin Lab Diagn 2021 Jun;66(6):353-357

State Research Center of Applied Microbiology and Biotechnology.

Tularemia is an especially dangerous infection caused by the gram-negative bacterium Francisella tularensis. It belongs to natural focal infections, and therefore is under continuous control by quarantine services. When carrying out their activities they use a whole range of diagnostic tools. Read More

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Rodent-Related Zoonotic Pathogens at the Human-Animal-Environment Interface in Qatar: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

School of Life Sciences, College of Agriculture, Engineering & Science, University of KwaZulu Natal, Durban 4000, South Africa.

Rodents are one of the most diversified terrestrial mammals, and they perform several beneficial activities in nature. These animals are also important as carriers of many pathogens with public health importance. The current systematic review was conducted to formulate a true depiction of rodent-related zoonoses in Qatar. Read More

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The Natural History of Aerosolized Infection in Cynomolgus Macaques.

Pathogens 2021 May 13;10(5). Epub 2021 May 13.

Core Support Directorate, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD 21702, USA.

Tularemia is a severe, zoonotic infection caused by the Gram-negative bacterium . Inhalation results in a rapid, severe bacterial pneumonia and sepsis, which can be lethal. Because the cynomolgus macaque is the accepted nonhuman primate model for tularemia, we conducted a natural history study of pneumonic tularemia by exposing macaques to target inhaled doses of 50, 500, or 5000 colony forming units (CFU) of subsp. Read More

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Identification of an Attenuated Substrain of SCHU S4 by Phenotypic and Genotypic Analyses.

Pathogens 2021 May 22;10(6). Epub 2021 May 22.

Center for Infectious Disease & Immunity and Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Pneumonic tularemia is a highly debilitating and potentially fatal disease caused by inhalation of Most of our current understanding of its pathogenesis is based on the highly virulent subsp. strain SCHU S4. However, multiple sources of SCHU S4 have been maintained and propagated independently over the years, potentially generating genetic variants with altered virulence. Read More

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A Rare Case of Tularemia Complicated by Rhabdomyolysis with a Successful Outcome.

Medicina (Kaunas) 2021 May 5;57(5). Epub 2021 May 5.

Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, 08410 Vilnius, Lithuania.

We present a case of tularemia complicated by rhabdomyolysis in a 43-year-old male who presented with fever, swelling, and pain of the right groin and a history of a week-old tick bite. Empirical parenteral amoxicillin/clavulanic acid treatment was initiated. Suspecting tularemia, parenteral gentamycin was added. Read More

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Genetic Determinants of Antibiotic Resistance in .

Front Microbiol 2021 12;12:644855. Epub 2021 May 12.

School of Systems Biology, George Mason University, Manassas, VA, United States.

Tularemia, caused by , is endemic to the northern hemisphere. This zoonotic organism has historically been developed into a biological weapon. For this Tier 1, Category A select agent, it is important to expand our understanding of its mechanisms of antibiotic resistance (AMR). Read More

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Genetic diversity of Francisella tularensis subsp. holarctica in Kazakhstan.

PLoS Negl Trop Dis 2021 May 17;15(5):e0009419. Epub 2021 May 17.

Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell, Gif-sur-Yvette, France.

Tularemia is a highly dangerous zoonotic infection due to the bacteria Francisella tularensis. Low genetic diversity promoted the use of polymorphic tandem repeats (MLVA) as first-line assay for genetic description. Whole genome sequencing (WGS) is becoming increasingly accessible, opening the perspective of a time when WGS might become the universal genotyping assay. Read More

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Tick-human interactions: from allergic klendusity to the α-Gal syndrome.

Biochem J 2021 May;478(9):1783-1794

SaBio, Instituto de Investigación de Recursos Cinegéticos, IREC-CSIC-UCLM-JCCM, Ronda de Toledo s/n, 13005 Ciudad Real, Spain.

Ticks and the pathogens they transmit, including bacteria, viruses, protozoa, and helminths, constitute a growing burden for human and animal health worldwide. The ability of some animal species to acquire resistance to blood-feeding by ticks after a single or repeated infestation is known as acquired tick resistance (ATR). This resistance has been associated to tick-specific IgE response, the generation of skin-resident memory CD4+ T cells, basophil recruitment, histamine release, and epidermal hyperplasia. Read More

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A study of innate immune kinetics reveals a role for a chloride transporter in a virulent Francisella tularensis type B strain.

Microbiologyopen 2021 Feb;10(2):e1170

The Alkek Center for Metagenomics and Microbiome Research, Baylor College of Medicine, Houston, TX, USA.

Tularemia is a zoonotic disease of global proportions. Francisella tularensis subspecies tularensis (type A) and holarctica (type B) cause disease in healthy humans, with type A infections resulting in higher mortality. Repeated passage of a type B strain in the mid-20th century generated the Live Vaccine Strain (LVS). Read More

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February 2021

The presence of Tularemia infection in patients with Japanese spotted fever.

J Dermatol 2021 May 5. Epub 2021 May 5.

Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.

In our previous study, by measuring serum cytokine levels in the acute and recovery stage of Japanese spotted fever (JSF), IFN-ɤ and IL-6 were proved to be the critical immunological cytokines against Rickettsia japonica (R. japonica) infection. Tularemia is an infectious disorder caused by tick biting or contact with infected animals, and is also known as rabbit fever. Read More

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Differential Immune Response Following Intranasal and Intradermal Infection with Implications for Vaccine Development.

Microorganisms 2021 Apr 30;9(5). Epub 2021 Apr 30.

Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA.

( is a Gram-negative, facultative intracellular coccobacillus that is the etiological agent of tularemia. Interestingly, the disease tularemia has variable clinical presentations that are dependent upon the route of infection with . Two of the most likely routes of infection include intranasal and intradermal, which result in pneumonic and ulceroglandular tularemia, respectively. Read More

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Antibodies Related to sensu lato, and Detected in Serum and Heart Rinses of Wild Small Mammals in the Czech Republic.

Pathogens 2021 Apr 1;10(4). Epub 2021 Apr 1.

Department of Mathematics and Statistics, Faculty of Science, Masaryk University, Kotlářská 2, 611 37 Brno, Czech Republic.

Wild small mammals are the most common reservoirs of pathogenic microorganisms that can cause zoonotic diseases. The aim of the study was to detect antibodies related to sensu lato, and in wild small mammals from the Czech Republic. In total, sera or heart rinses of 211 wild small mammals (168 , 28 , 9 , and 6 ) were examined by modified enzyme-linked immunosorbent assay. Read More

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Emerging and Re-emerging Infectious Diseases in the WHO Eastern Mediterranean Region, 2001-2018.

Int J Health Policy Manag 2021 Mar 6. Epub 2021 Mar 6.

Department of Primary Care and Public Health, School of Public Health, Faculty of Medicine, Imperial College, London, UK.

Background: Countries in the World Health Organization (WHO) Eastern Mediterranean Region (EMR) are predisposed to highly contagious, severe and fatal, emerging infectious diseases (EIDs), and re-emerging infectious diseases (RIDs). This paper reviews the epidemiological situation of EIDs and RIDs of global concern in the EMR between 2001 and 2018.

Methods: To do a narrative review, a complete list of studies in the field was we prepared following a systematic search approach. Read More

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Type VI secretion system and its effectors PdpC, PdpD and OpiA contribute to virulence in larvae.

Infect Immun 2021 Apr 19. Epub 2021 Apr 19.

Biozentrum, University of Basel, Switzerland

causes the deadly zoonotic disease tularemia in humans and is able to infect a broad range of organisms including arthropods, which are thought to play a major role in transmission. However, while mammalian and infection models are widely used to investigate pathogenicity, a detailed characterization of the major virulence factor, a non-canonical T6SS, in an arthropod infection model is missing. Here we use larvae to analyze the role of the T6SS and its corresponding effectors in virulence. Read More

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Aim2 and Nlrp3 Are Dispensable For Vaccine-Induced Immunity Against Live Vaccine Strain.

Infect Immun 2021 Apr 19. Epub 2021 Apr 19.

Department of Pathology, Microbiology and Immunology, New York Medical College, Valhalla, New York, USA

() is a facultative intracellular, Gram-negative bacterium that causes a fatal disease known as tularemia. Due to its extremely high virulence, ease of spread by aerosolization, and the potential to be used as a bioterror agent, is classified by the CDC as a Tier 1 Category A Select Agent. Previous studies have demonstrated the roles of inflammasome sensors; absent in melanoma 2 (AIM2) and NLRP3, in the generation of innate immune responses to infection. Read More

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Molecular detection of Coxiella burnetii infection in aborted samples of domestic ruminants in Iran.

PLoS One 2021 14;16(4):e0250116. Epub 2021 Apr 14.

Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

Background: Coxiella burnetii is the causative agent of Q fever which is a highly infectious zoonotic disease. C. burnetii has become one of the most important causes of abortion in livestock, which can lead to widespread abortions in these animals. Read More

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Ulceroglandular Tularemia.

N Engl J Med 2021 Apr;384(14):1349

University of Lucerne, Lucerne, Switzerland.

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J Wildl Dis 2021 04;57(2):264-272

US Geological Survey, National Wildlife Health Center, 6006 Schroeder Rd., Madison, Wisconsin 53711, USA.

As part of the national recovery effort, endangered black-footed ferrets (Mustela nigripes) were reintroduced to the Cheyenne River Sioux Reservation in South Dakota, US in 2000. Despite an encouraging start, numbers of ferrets at the site have declined. In an effort to determine possible causes of the population decline, we undertook a pathogen survey in 2012 to detect exposure to West Nile virus (WNV), canine distemper virus (CDV), plague (Yersinia pestis), tularemia (Francisella tularensis), and heartworm (Dirofilaria immitis) using coyotes (Canis latrans) as a sentinel animal. Read More

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Likely Geographic Distributional Shifts among Medically Important Tick Species and Tick-Associated Diseases under Climate Change in North America: A Review.

Insects 2021 Mar 5;12(3). Epub 2021 Mar 5.

Biodiversity Institute, University of Kansas, Lawrence, KS 66045, USA.

Ticks rank high among arthropod vectors in terms of numbers of infectious agents that they transmit to humans, including Lyme disease, Rocky Mountain spotted fever, Colorado tick fever, human monocytic ehrlichiosis, tularemia, and human granulocytic anaplasmosis. Increasing temperature is suspected to affect tick biting rates and pathogen developmental rates, thereby potentially increasing risk for disease incidence. Tick distributions respond to climate change, but how their geographic ranges will shift in future decades and how those shifts may translate into changes in disease incidence remain unclear. Read More

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Analyses of tularemia cases and their long-term results.

Trop Biomed 2021 Mar;38(1):130-134

Department of Otorhinolaryngology, School of Medicine, FKrat University, ElazK%g , Turkey.

Tularemia is a zoonotic disease and endemic in the northern hemisphere. The aim of this study was to evaluate the epidemiological, clinical and laboratory characteristics of tularemia patients, and to re-analyze their lymphadenopathy during the follow-up. The patients who were diagnosed with tularemia were reviewed. Read More

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Francisella tularensis human infections in a village of northwest Iran.

BMC Infect Dis 2021 Mar 31;21(1):310. Epub 2021 Mar 31.

National Reference laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.

Background: Recent seroepidemiological studies have suggested that tularemia could be an endemic bacterial zoonosis in Iran.

Methods: From January 2016 to June 2018, disease cases characterized by fever, cervical lymphadenopathy and ocular involvement were reported in Youzband Village of Kaleybar County, in the East Azerbaijan Province, northwestern Iran. Diagnostic tests included Francisella tularensis serology (including tube agglutination test and ELISA), PCR, and culture. Read More

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Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters.

NPJ Vaccines 2021 Mar 30;6(1):47. Epub 2021 Mar 30.

Division of Infectious Diseases, Department of Medicine, 37-121 Center for Health Sciences, School of Medicine, University of California - Los Angeles, Los Angeles, CA, USA.

To generate an inexpensive readily manufactured COVID-19 vaccine, we employed the LVS ΔcapB vector platform, previously used to generate potent candidate vaccines against Select Agent diseases tularemia, anthrax, plague, and melioidosis. Vaccines expressing SARS-CoV-2 structural proteins are constructed using the LVS ΔcapB vector, a highly attenuated replicating intracellular bacterium, and evaluated for efficacy in golden Syrian hamsters, which develop severe COVID-19-like disease. Hamsters immunized intradermally or intranasally with a vaccine co-expressing the Membrane and Nucleocapsid proteins and challenged 5 weeks later with a high dose of SARS-CoV-2 are protected against severe weight loss and lung pathology and show reduced viral loads in the oropharynx and lungs. Read More

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Survey on tick distribution and tick-borne pathogens in Daejeon and adjacent areas in South Korea.

Ticks Tick Borne Dis 2021 07 15;12(4):101711. Epub 2021 Mar 15.

Daejeon Metropolitan City Institute of Health and Environment, 407 Daehak-ro, Yuseong-gu, Daejeon, 34142, Republic of Korea.

Ticks (Ixodidae, also known as hard ticks) as principal vectors of zoonotic diseases such as severe fever with thrombocytopenia syndrome (SFTS), Lyme borreliosis, relapsing fever, anaplasmosis, ehrlichiosis, babesiosis, coxiellosis (Q fever), and tularemia pose a major public health threat. This study was conducted to identify the distribution profile of ticks and tick-borne pathogens in Daejeon and the adjacent areas in South Korea, where no such epidemiological study has been conducted. From April to October 2019, 16,765 ticks were collected from three genera and four species: Haemaphysalis longicornis (n = 14,949; 89. Read More

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Inguinal Ulceroglandular Tularemia Caused by Francisella tularensis Subspecies holarctica, Canada.

Emerg Infect Dis 2021 ;27(4):1228-1229

Tularemia is a zoonotic disease caused by the gram-negative coccobacillus Francisella tularensis, a Biosafety Level 3 pathogen and potential agent of bioterrorism. We describe 2 cases of perigenital ulcer disease caused by Francisella tularensis subspecies holarctica in Manitoba, Canada. These cases caused inadvertent exposure among laboratory personnel. Read More

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January 2021

Finafloxacin Is an Effective Treatment for Inhalational Tularemia and Plague in Mouse Models of Infection.

Antimicrob Agents Chemother 2021 05 18;65(6). Epub 2021 May 18.

Defence Science and Technology Laboratory, Porton Down, Salisbury, United Kingdom

Infection with aerosolized or can lead to lethal disease in humans if treatment is not initiated promptly. Finafloxacin is a novel fluoroquinolone which has demonstrated broad-spectrum activity against a range of bacterial species , and in humans, activity which is superior in acidic, infection-relevant conditions. Human-equivalent doses of finafloxacin or ciprofloxacin were delivered at 24 h (representing prophylaxis) or at 72 or 38 h (representing treatment) postchallenge with or , respectively, in BALB/c mouse models. Read More

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A Rare Case of Spontaneous Splenic Rupture Secondary to Tularemia Following a Cat Bite.

Cureus 2021 Feb 8;13(2):e13218. Epub 2021 Feb 8.

Internal Medicine, University of North Dakota, Fargo, USA.

Spontaneous splenic rupture is a rare but potentially life-threatening condition. More common infectious causes include infectious mononucleosis, cytomegalovirus (CMV), human immunodeficiency virus (HIV), and malaria. We present a case of a 42-year-old male who was admitted with persistent fevers, myalgia, and a recent ulcerative lesion on the base of his left thumb after a cat bite. Read More

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February 2021

Neurologic Manifestations of the World Health Organization's List of Pandemic and Epidemic Diseases.

Front Neurol 2021 22;12:634827. Epub 2021 Feb 22.

Department of Neurology, Massachusetts General Hospital, Boston, MA, United States.

The World Health Organization (WHO) monitors the spread of diseases globally and maintains a list of diseases with epidemic or pandemic potential. Currently listed diseases include Chikungunya, cholera, Crimean-Congo hemorrhagic fever, Ebola virus disease, Hendra virus infection, influenza, Lassa fever, Marburg virus disease, , MERS-CoV, monkeypox, Nipah virus infection, novel coronavirus (COVID-19), plague, Rift Valley fever, SARS, smallpox, tularemia, yellow fever, and Zika virus disease. The associated pathogens are increasingly important on the global stage. Read More

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February 2021

The European Union One Health 2019 Zoonoses Report.


EFSA J 2021 Feb 27;19(2):e06406. Epub 2021 Feb 27.

This report of the EFSA and the European Centre for Disease Prevention and Control presents the results of zoonoses monitoring activities carried out in 2019 in 36 European countries (28 Member States (MS) and eight non-MS). The first and second most reported zoonoses in humans were campylobacteriosis and salmonellosis, respectively. The EU trend for confirmed human cases of these two diseases was stable (flat) during 2015-2019. Read More

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February 2021

Factors Affecting Cervical Lymph Node Suppuration in Oropharyngeal Tularemia Cases.

J Coll Physicians Surg Pak 2021 Feb;31(2):193-196

Department of Infectious Diseases, Faculty of Medicine, Abant Izzet Baysal University, Bolu, Turkey.

Objective:  To determine the factors associated with cervical lymph node suppuration in oropharyngeal tularemia.

Study Design: Observational study.

Place And Duration Of Study:  Departments of Infectious Diseases and Clinical Microbiology, Faculties of Medicine, Duzce University and Bolu Abant Izzet Baysal University Turkey, between January 2016 and August 2019. Read More

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February 2021

Utilization of a tetracycline-inducible system for high-level expression of recombinant proteins in Francisella tularensis LVS.

Plasmid 2021 May 18;115:102564. Epub 2021 Feb 18.

Department of Molecular Pathology and Biology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.

Francisella tularensis is a Gram-negative intracellular pathogen causing tularemia. A number of its potential virulence factors have been identified, but their biology and functions are not precisely known. Understanding the biological and immunological functions of these proteins requires adequate genetic tools for homologous and heterologous expression of cloned genes, maintaining both original structure and post-translational modifications. Read More

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