4,446 results match your criteria Tularemia


A case report of ulceroglandular tularemia caused by Francisella tularensis subsp. holarctica in Iran.

Acta Trop 2022 Jun 22:106570. Epub 2022 Jun 22.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging infectious diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Background: Tularemia is a zoonotic disease that has been reported in many countries of the Northern Hemisphere. However, in some countries, such as Iran, this disease has been neglected by the health care system, and it is under-reported.

Case Presentation: Here we report an unusual case of ulceroglandular tularemia occurring in a 35-year-old woman who presented with a skin lesion of the left flank, inguinal lymphadenopathy, and an abdominal abscess. Read More

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Skin involvement in Francisella tularensis infection: a case report of two clinical cases.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):89-92

Department of Infectious Diseases, University Medical Center Maribor, Maribor, Slovenia.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. Read More

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Skin involvement in Francisella tularensis infection: a case report of two clinical cases.

Acta Dermatovenerol Alp Pannonica Adriat 2022 Jun;31(2):83-87

Department of Infectious Diseases, University Medical Center Maribor, Maribor, Slovenia.

Tularemia, or rabbit fever, is a zoonotic infection caused by Francisella tularensis, a Gram-negative coccobacillus. F. tularensis subsp. Read More

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[Mediastinal Lymphadenopathy - Tuberculosis or Tularemia?]

Laryngorhinootologie 2022 Jul 23;101(7):594-596. Epub 2022 Jun 23.

Abteilung für Tropenmedizin und Infektionskrankheiten und Sektion Nephrologie, Universitätsmedizin Rostock.

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Metabolic Reprogramming Mediates Delayed Apoptosis of Human Neutrophils Infected With .

Front Immunol 2022 25;13:836754. Epub 2022 May 25.

Inflammation Program, University of Iowa, Iowa City, IA, United States.

Neutrophils (polymorphonuclear leukocytes, PMNs) have a distinctively short lifespan, and tight regulation of cell survival and death is imperative for their normal function. We demonstrated previously that extends human neutrophil lifespan, which elicits an impaired immune response characterized by neutrophil dysfunction. Herein, we extended these studies, including our transcriptional profiling data, and employed Seahorse extracellular flux analysis, gas chromatography-mass spectrometry metabolite analysis, flow cytometry and several other biochemical approaches to demonstrate that the delayed apoptosis observed in -infected neutrophils is mediated, in part, by metabolic reprogramming. Read More

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Mutational Switch-Backs Can Accelerate Evolution of to a Combination of Ciprofloxacin and Doxycycline.

Front Microbiol 2022 9;13:904822. Epub 2022 May 9.

Department of Biosciences, Rice University, Houston, TX, United States.

Combination antimicrobial therapy has been considered a promising strategy to combat the evolution of antimicrobial resistance. is the causative agent of tularemia and in addition to being found in the nature, is recognized as a threat agent that requires vigilance. We investigated the evolutionary outcome of adapting the Live Vaccine Strain (LVS) of subsp. Read More

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Pharyngeal tularemia acquired in an urban setting in Canada.

CMAJ 2022 May;194(20):E701-E703

Departments of Medical Microbiology and Infectious Diseases (Walkty, Keynan) and of Internal Medicine (Vickers, Walkty, Keynan), Max Rady College of Medicine, University of Manitoba; Shared Health (Walkty), Winnipeg, Man.

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The balance of interleukin-12 and interleukin-23 determines the bias of MAIT1 versus MAIT17 responses during bacterial infection.

Immunol Cell Biol 2022 May 6. Epub 2022 May 6.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Melbourne, VIC, Australia.

Mucosal-associated invariant T (MAIT) cells are a major subset of innate-like T cells mediating protection against bacterial infection through recognition of microbial metabolites derived from riboflavin biosynthesis. Mouse MAIT cells egress from the thymus as two main subpopulations with distinct functions, namely, T-bet-expressing MAIT1 and RORγt-expressing MAIT17 cells. Previously, we reported that inducible T-cell costimulator and interleukin (IL)-23 provide essential signals for optimal MHC-related protein 1 (MR1)-dependent activation and expansion of MAIT17 cells in vivo. Read More

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Tularemia research activity: a bibliometric analysis between 1980 and 2020.

Infection 2022 May 4. Epub 2022 May 4.

Department of Family Medicine, Public Health Directorate of Kahramanmaraş, Kahramanmaraş city, Turkey.

Introduction: Tularemia disease attracts attention as an important contagious zoonosis that has increased its impact in recent years. The aim of the study is to analyze the publications on tularemia between 1980 and 2020.

Methods: We performed literature retrieval in the Web of Science (WoS) on 22 September 2021. Read More

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An Unusual Case of .

Case Rep Infect Dis 2022 18;2022:7250294. Epub 2022 Apr 18.

Department of Infectious Disease, Carle Foundation Hospital, Urbana, IL, USA.

A 67-year-old male presented with complaints of weakness, fatigue, and shortness of breath in the context of a recent hospitalization for the same unresolved symptoms. After a largely nonspecific clinical presentation, a chest X-ray revealed a loculated pleural effusion. Culture of the postthoracentesis exudate revealed the culprit to be the aerobic Gram-negative bacterium . Read More

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ThioredoxinA1 Controls the Oxidative Stress Response of Francisella tularensis Live Vaccine Strain (LVS).

J Bacteriol 2022 05 27;204(5):e0008222. Epub 2022 Apr 27.

Department of Basic and Clinical Sciences, Albany College of Pharmacy and Health Sciencesgrid.413555.3, Albany, New York, USA.

Francisella tularensis is an intracellular, Gram-negative bacterium known for causing a disease known as tularemia in the Northern Hemisphere. F. tularensis is classified as a category A select agent by the CDC based on its possible use as a bioterror agent. Read More

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[Pulmonary tularemia : a diagnosis not to be missed].

Rev Med Suisse 2022 Apr;18(777):707-711

Service des maladies infectieuses, Centre hospitalier universitaire vaudois et Université de Lausanne, 1011 Lausanne.

Tularemia (caused by the facultative intracellular Gram-negative bacillus Francisella tularensis) is an endemic zoonotic disease in Europe, which exhibits different clinical patterns. Following the glandular form, pneumonia is the second most frequent manifestation in Switzerland. Pulmonary tularemia often has a subacute course and fails to respond to beta-lactam antibiotics. Read More

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Potency, toxicity and protection evaluation of PastoCoAd candidate vaccines: Novel preclinical mix and match rAd5 S, rAd5 RBD-N and SOBERANA dimeric-RBD protein.

Vaccine 2022 May 4;40(20):2856-2868. Epub 2022 Apr 4.

Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Despite substantial efforts, no effective treatment has been discovered for severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. Therefore, vaccination to reach herd immunity is the ultimate solution to control the coronavirus disease 2019 (COVID-19) pandemic. This study aimed to evaluate the potency, toxicity, and protection of candidate PastoCoAd vaccines as novel mix and match of recombinant adenovirus type 5 (rAd5) containing the full-length spike protein (rAd5-S), rAd5 containing the receptor-binding domain of S protein and nucleoprotein (rAd5 RBD-N), and SOBERANA dimeric RBD protein of SARS-CoV-2. Read More

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Rickettsia conorii subsp. israelensis infection: a case report from southeast Iran.

BMC Infect Dis 2022 Apr 1;22(1):320. Epub 2022 Apr 1.

Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

Background: Mediterranean spotted fever (MSF) is a zoonotic and vector-borne disease caused by Rickettsia conorii. We report a case (36 year-old-woman) of MSF caused by Rickettsia conorii from Iran.

Case Presentation: In September 2019, the patient was admitted to the hospital in Kerman province with flu-like symptoms and maculopapular lesions. Read More

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Molecular detection and identification of Rickettsia spp. in collected ticks from domestic animals in Southeastern of Iran.

Comp Immunol Microbiol Infect Dis 2022 Jun 22;85:101798. Epub 2022 Mar 22.

Department of Microbiology, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Ticks are considered as the reservoirs for pathogenic Rickettsia for humans and domestic animals. Recently, clinical cases of rickettsiosis have been reported from Iran and its surrounding countries. This study was aimed at investigating the prevalence of Rickettsia spp. Read More

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Tularaemia - a diagnostic challenge.

Ann Agric Environ Med 2022 Mar 20;29(1):12-21. Epub 2021 Aug 20.

Department of Bacteriology and Biocontamination Control, National Institute of Public Health NIH - National Research Institute, Warsaw, Poland.

Introduction And Objective: Tularaemia is an infrequently occurring disease in Poland. It has therefore rarely been taken into account in the differential diagnosis of skin lesions, lymphadenitis, or soft tissue abscesses. This fact, accompanied by non-specific initial presentation, may lead to a delay in diagnosis and a more severe course of the disease. Read More

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Francisella tularensis infection: variable clinical aspects with persistent pulmonary nodules presentation, a case series of human tularemia in Franche-Comté, France.

Ticks Tick Borne Dis 2022 05 10;13(3):101941. Epub 2022 Mar 10.

Infectious Disease Department, Nord Franche-Comté Hospital, France.

Tularemia is a zoonotic infectious disease caused by the facultative intracellular Gram-negative bacterium Francisella tularensis. Depending on the transmission route of this agent tularemia can present itself as a local infection or a systemic disease. We describe herein three cases of confirmed tularemia in immunocompetent patients during the summer of 2019; two patients with unusual respiratory presentation and pulmonary nodules on imaging, following exposure to aerosols. Read More

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Tularemia Transmission to Humans, the Netherlands, 2011-2021.

Emerg Infect Dis 2022 04;28(4):883-885

We used national registry data on human cases of Francisella tularensis subspecies holarctica infection to assess transmission modes among all 26 autochthonous cases in the Netherlands since 2011. The results indicate predominance of terrestrial over aquatic animal transmission sources. We recommend targeting disease-risk communication toward hunters, recreationists, and outdoor professionals. Read More

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Alginate microencapsulation of an attenuated O-antigen mutant of Francisella tularensis LVS as a model for a vaccine delivery vehicle.

PLoS One 2022 11;17(3):e0259807. Epub 2022 Mar 11.

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, Virginia, United States of America.

Francisella tularensis is the etiologic agent of tularemia and a Tier I Select Agent. Subspecies tularensis (Type A) is the most virulent of the four subspecies and inhalation of as few as 10 cells can cause severe disease in humans. Due to its niche as a facultative intracellular pathogen, a successful tularemia vaccine must induce a robust cellular immune response, which is best achieved by a live, attenuated strain. Read More

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Molecular detection of Francisella tularensis in small ruminants and their ticks in western Iran.

Comp Immunol Microbiol Infect Dis 2022 Apr 24;83:101779. Epub 2022 Feb 24.

National Reference Laboratory for Plague, Tularemia and Q fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran; Department of Epidemiology and Biostatics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Francisella tularensis is the causative agent of tularemia an infectious zoonotic disease. We attempted the molecular detecting of F. tularensis in small ruminants and ticks attached to these animals in Kurdistan province (the west of Iran). Read More

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Proteomic Signatures of Antimicrobial Resistance in and .

Front Med (Lausanne) 2022 10;9:821071. Epub 2022 Feb 10.

Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, United States.

Antimicrobial resistance (AMR) is a well-recognized, widespread, and growing issue of concern. With increasing incidence of AMR, the ability to respond quickly to infection with or exposure to an AMR pathogen is critical. Approaches that could accurately and more quickly identify whether a pathogen is AMR also are needed to more rapidly respond to existing and emerging biological threats. Read More

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February 2022

Tropheryma whipplei in the stool samples of children with acute diarrhea: a study from Tehran, Iran.

BMC Infect Dis 2022 Feb 27;22(1):193. Epub 2022 Feb 27.

National Reference Laboratory for Plague, Tularemia and Q Fever, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Akanlu, Kabudar Ahang, Hamadan, Iran.

Background: Recently, Tropheryma whipplei has been suggested as one of the causative agents of diarrhea among children worldwide. Limited data is available on the prevalence of T. whipplei among children with diarrhea in most countries such as Iran. Read More

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February 2022

Assessment of Zoonotic Risk following Diagnosis of Canine Tularemia in a Veterinary Medical Teaching Hospital.

Int J Environ Res Public Health 2022 02 11;19(4). Epub 2022 Feb 11.

Department of Pathology, Microbiology, and Immunology, University of California-Davis, 4206 VM3A, Davis, CA 95616, USA.

Tularemia is a rare zoonotic disease found worldwide. The agent responsible for disease, , is one of the most highly infectious pathogens known, one that is capable of causing life-threatening illness with inhalation of <50 organisms. High infectivity explains concerns of its use in bioterrorism. Read More

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February 2022

Circulating T Cells Are Not Sufficient for Protective Immunity against Virulent .

J Immunol 2022 03 11;208(5):1180-1188. Epub 2022 Feb 11.

Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT; and

Pulmonary infections elicit a combination of tissue-resident and circulating T cell responses. Understanding the contribution of these anatomically distinct cellular pools in protective immune responses is critical for vaccine development. is a highly virulent bacterium capable of causing lethal systemic disease following pulmonary infection for which there is no currently licensed vaccine. Read More

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Itaconate indirectly influences expansion of effector T cells following vaccination with Francisella tularensis live vaccine strain.

Cell Immunol 2022 03 7;373:104485. Epub 2022 Feb 7.

Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, Rocky Mountain Laboratories, NIAID, NIH, 903 S. 4th Street Hamilton, Montana, 59840, United States. Electronic address:

The metabolite itaconate plays a critical role in modulating inflammatory responses among macrophages infected with intracellular pathogens. However, the ability of itaconate to influence developing T cells responses is poorly understood. To determine if itaconate contributes to the quality of T cell mediated immunity against intracellular infection, we used Francisella tularensis as a model of vaccine induced immunity. Read More

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Phase Variation of LPS and Capsule Is Responsible for Stochastic Biofilm Formation in .

Front Cell Infect Microbiol 2021 14;11:808550. Epub 2022 Jan 14.

Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), Frederick, MD, United States.

Biofilms have been established as an important lifestyle for bacteria in nature as these structured communities often enable survivability and persistence in a multitude of environments. is a facultative intracellular Gram-negative bacterium found throughout much of the northern hemisphere. However, biofilm formation remains understudied and poorly understood in as non-substantial biofilms are typically observed by the clinically relevant subspecies subsp. Read More

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Sensitivity of an international notification system for wildlife diseases: A case study using the OIE-WAHIS data on tularemia.

Zoonoses Public Health 2022 Jun 29;69(4):286-294. Epub 2022 Jan 29.

World Animal Health Information and Analysis Department, World Organisation for Animal Health (OIE), Paris, France.

The World Organization for Animal Health (OIE) has recently developed a Wildlife Health Framework to respond to the need of members to manage the risk from emerging diseases at the animal-human-ecosystem interface. One of its objectives is to improve surveillance systems, early detection and notification of wildlife diseases. Members share information on disease occurrence by reporting through the OIE World Animal Health Information System (OIE-WAHIS-formerly known as 'WAHIS'). Read More

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Is clinical primary care surveillance for tularaemia a useful addition to laboratory surveillance? An analysis of notification data for Finland, 2013 to 2019.

Euro Surveill 2022 Jan;27(4)

Department of Health Security, Finnish Institute for Health and Welfare (THL), Helsinki, Finland.

BackgroundIn Finland, surveillance of tularaemia relies on laboratory-confirmed case notifications to the National infectious Diseases Register (NIDR).AimThe aim of the study was to assess the suitability and usefulness of clinical surveillance as an addition to laboratory notification to improve tularaemia surveillance in Finland.MethodsWe retrieved NIDR tularaemia surveillance and primary healthcare data on clinically diagnosed tularaemia cases in Finland between 2013 and 2019. Read More

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January 2022

Draft Genome Sequence of Francisella tularensis subsp. Strain H0001, Isolated from a Tularemia Patient in the Republic of Korea.

Microbiol Resour Announc 2022 Feb 27;11(2):e0071921. Epub 2022 Jan 27.

Division of High-Risk Pathogens, Bureau of Infectious Disease Diagnosis Control, Korea Disease Control and Prevention Agency, Cheongju, Republic of Korea.

Francisella tularensis is the etiological agent of the zoonosis tularemia. Here, we report the draft genome sequence of F. tularensis subsp. Read More

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February 2022

The type IV pili component PilO is a virulence determinant of Francisella novicida.

PLoS One 2022 25;17(1):e0261938. Epub 2022 Jan 25.

Faculty of Medicine, Department of Microbiology and Parasitology, University of Rijeka, Rijeka, Croatia.

Francisella tularensis is a highly pathogenic intracellular bacterium that causes the disease tularemia. While its ability to replicate within cells has been studied in much detail, the bacterium also encodes a less characterised type 4 pili (T4P) system. T4Ps are dynamic adhesive organelles identified as major virulence determinants in many human pathogens. Read More

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February 2022