240 results match your criteria Tufted Angioma


Propranolol Followed by a Foam Sclerotherapy for Treatment of Tufted Angioma over Neck: A Novel Therapeutic Approach.

J Cutan Aesthet Surg 2020 Oct-Dec;13(4):335-337

Department of Dermatology, MVP's Dr. Vasantrao Pawar Medical College Hospital and Research Center, Nashik, Maharashtra, India.

Tufted angioma is a rare vascular tumor with cutaneous angiomatous proliferation, commonly localized in the skin and subcutaneous tissues. Most cases are usually acquired in childhood, having protracted course with minimal tendency for spontaneous regression. Various treatment modalities have been described in the literature in the management of tufted angioma with variable response. Read More

View Article and Full-Text PDF

Tufted angioma with coagulopathy: a dermoscopic evaluation and successful treatment.

Int J Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Department of Dermatology and Sexually Transmitted Diseases, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

View Article and Full-Text PDF

Vascular Anomalies of the Head and Neck: A Pediatric Overview.

Head Neck Pathol 2021 Mar 15;15(1):59-70. Epub 2021 Mar 15.

Department of Pathology, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA, 02115, USA.

Vascular anomalies, further classified into vascular tumors and malformations, often involve the head and neck region of children. These entities may raise diagnostic dilemmas, as they often demonstrate heterogenous and overlapping histologic features. The aim of this paper is to provide an overview of the common vascular anomalies in the head and neck region of children. Read More

View Article and Full-Text PDF

Comparison of efficacy and safety of corticosteroid and vincristine in treating kaposiform hemangioendothelioma and tufted angioma: A multicenter prospective randomized controlled clinical trial.

J Dermatol 2021 May 19;48(5):576-584. Epub 2021 Feb 19.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.

Kaposiform haemangioendothelioma (KHE) and tufted angioma (TA) are rare vascular tumors that can cause life-threatening Kasabach-Merritt phenomenon. No evidence-based treatment strategies have yet been established, and its management is still a challenge. The purpose of this multicenter prospective randomized controlled study was to evaluate and compare the efficacy of corticosteroid and vincristine (VCR) in the treatment of KHE and TA. Read More

View Article and Full-Text PDF

Severe adverse events during sirolimus "off-label" therapy for vascular anomalies.

Pediatr Blood Cancer 2021 Feb 13:e28936. Epub 2021 Feb 13.

Division of Pediatric Hematology and Oncology, Department of Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Objectives: Clinical studies have shown low toxicity and a favorable safety profile for sirolimus in vascular anomalies. Here, we describe severe adverse events (SAEs) observed during "off-label use" for vascular anomalies.

Methods: We performed a retrospective, multicenter chart review for SAEs during "off-label" sirolimus therapy for vascular anomalies and analyzed these cases by a predesigned workflow. Read More

View Article and Full-Text PDF
February 2021

The role of topical timolol in wound healing and the treatment of vascular lesions: A narrative review.

Dermatol Ther 2021 03 13;34(2):e14847. Epub 2021 Feb 13.

Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences (IUMS), Tehran, Iran.

Beta-2 adrenergic receptors are the only subgroup of beta-adrenergic receptors expressed in the membrane of large cells, including skin keratinocytes, fibroblasts, and melanocytes. Alterations in the function or concentration of β2 adrenoreceptors related to keratinocytes are associated with some skin conditions. Some findings suggest the role of β2 adrenoreceptors in maintaining the function and integrity of the epidermis. Read More

View Article and Full-Text PDF

Multifocal annular tufted angiomas: Case report of dramatic response to oral prednisolone and review of therapeutic options.

Dermatol Ther 2021 01 16;34(1):e14666. Epub 2020 Dec 16.

Department of Dermatology, Katihar Medical College and Hospital, Katihar, Bihar, India.

View Article and Full-Text PDF
January 2021

Case of tufted angioma treated successfully with tranilast, topical steroids and tacrolimus ointment.

J Dermatol 2021 Feb 16;48(2):e84-e85. Epub 2020 Nov 16.

Department of Dermatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

View Article and Full-Text PDF
February 2021

Kasabach-Merritt-like phenomenon in a massive uterine leiomyoma presenting with chronic disseminated intravascular coagulation: A case report.

Case Rep Womens Health 2020 Oct 6;28:e00262. Epub 2020 Oct 6.

Ascension Providence Hospital, Department of Hematology/Oncology, Department of Gynecological Oncology, 16001 W. Nine Mile Rd., Southfield, MI 48075, United States of America.

Kasabach-Merritt phenomenon is a process where the presence of vascular irregularity within a Kaposiform hemangioendothelioma or tufted angioma leads to constitutive coagulation factor activation and the development of chronic disseminated intravascular coagulation (DIC). A similar phenomenon has been seen in other tumors but has rarely been described. A 42-year-old woman presented to the hospital following the development of worsening easy bruising and bleeding. Read More

View Article and Full-Text PDF
October 2020

Topical tacrolimus reduces the severe pain of tufted angioma: Case report.

Dermatol Ther 2020 11 27;33(6):e14412. Epub 2020 Oct 27.

Department of Dermatology and Venereology, West China Hospital, SiChuan University, SiChuan, China.

View Article and Full-Text PDF
November 2020

Kasabach-Merritt phenomenon with cellulitis in infant.

BMJ Case Rep 2020 Sep 15;13(9). Epub 2020 Sep 15.

Department of Dermatology and Venereology, Universitas Sumatera Utara Fakultas Kedokteran, Medan, Indonesia.

Kasabach-Merritt phenomenon (KMP) is consumptive coagulopathy in large vascular lesion. This condition is specific in kaposiform haemangioendothelioma (KHE) and tufted angioma, associated with high mortality rate. This condition often involves the limbs, trunk and retroperitoneum. Read More

View Article and Full-Text PDF
September 2020

Tufted angioma with Kasabach-Merritt syndrome: Two cases successfully treated with everolimus.

Pediatr Blood Cancer 2020 06 10;67(6):e28291. Epub 2020 Apr 10.

Department of Dermatology, Mohammed VI University Hospital Center, Cadi Ayyad University, Marrakech, Morocco.

View Article and Full-Text PDF

Immunohistochemical Analysis of mTOR Pathway-Related Proteins in Kaposiform Hemangioendothelioma.

Dermatology 2020 2;236(3):262-270. Epub 2020 Jan 2.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, China.

Background: Mammalian target of rapamycin (mTOR) inhibitors have been shown to have excellent effects in the management of kaposiform hemangioendothelioma (KHE); however, the mechanism of action is unclear. This study identified the expressions of mTOR pathway-related proteins in different vascular tumors to provide insight into the pathogenesis of KHE.

Methods: We retrospectively reviewed the pathologic specimens of 30 patients (KHE, 15; tufted angioma [TA], 5; infantile hemangioma [IH], 5; and lymphatic malformation [LM], 5). Read More

View Article and Full-Text PDF
September 2020

Kaposiform hemangioendothelioma and tufted angioma - (epi)genetic analysis including genome-wide methylation profiling.

Ann Diagn Pathol 2020 Feb 10;44:151434. Epub 2019 Dec 10.

Department of Pathology, Radboud University Medical Center, Nijmegen, the Netherlands; Princess Màxima Center for Pediatric Oncology, Utrecht, the Netherlands. Electronic address:

Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular condition of childhood and is clinicopathologically related to tufted angioma (TA), a benign skin lesion. Due to their rarity molecular data are scarce. We investigated 7 KHE and 3 TA by comprehensive mutational analysis and genome-wide methylation profiling and compared the clustering, also with vascular malformations. Read More

View Article and Full-Text PDF
February 2020

Tufted angioma presenting with subclinical coagulopathy.

Dermatol Online J 2019 Sep 15;25(9). Epub 2019 Sep 15.

Department of Dermatology, Wake Forest Baptist Medical Center, Winston Salem, NC.

Tufted angioma is a rare, benign vascular tumor of uncertain pathogenesis, characterized histopathologically by "tufts" of capillaries within the dermis. A life-threatening coagulopathy, Kasabach-Merritt phenomenon, occurs in approximately 10% of cases of tufted angioma and is characterized by profound thrombocytopenia and fibrinogen consumption. We present an asymptomatic 10-month-old boy who presented with an erythematous patch of the right upper extremity and subsequently was diagnosed by biopsy with tufted angioma. Read More

View Article and Full-Text PDF
September 2019

Oral itraconazole for the treatment of giant tufted angioma with hair loss arising during pregnancy: A case report.

J Dermatol 2020 Feb 14;47(2):e35-e36. Epub 2019 Nov 14.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

View Article and Full-Text PDF
February 2020

What is new in endothelial neoplasia?

Virchows Arch 2020 Jan 28;476(1):17-28. Epub 2019 Aug 28.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, USA.

The classification of vascular neoplasms continues to evolve as we accumulate more genetic and clinical data, particularly for rare tumor types. Because of tumor rarity, changes to classification schema, overlapping histologic features, and in some cases, lack of morphologic evidence of vasoformation, vascular neoplasms present a diagnostic challenge. Here, we discuss recent developments in our understanding of vascular tumors, with a detailed discussion of epithelioid hemangioma, tufted angioma, kaposiform hemangioendothelioma, composite hemangioendothelioma, pseudomyogenic hemangioendothelioma, epithelioid hemangioendothelioma, and angiosarcoma. Read More

View Article and Full-Text PDF
January 2020

Tufted angioma with associated Kasabach-Merritt phenomenon caused by somatic mutation in GNA14.

Pediatr Dermatol 2019 Nov 18;36(6):963-964. Epub 2019 Aug 18.

Department of Dermatology, Yale University School of Medicine, New Haven, CT, USA.

Tufted angioma (TA) is a rare vascular tumor characterized by histologic tufts of proliferating capillaries that occurs in infancy or early childhood, with a poorly understood pathogenesis. Though benign, TA can be associated with the Kasabach-Merritt phenomenon (KMP), a life-threatening consumptive coagulopathy and thrombocytopenia. Here, we explored the genetic mechanism underlying a case of TA associated with KMP via targeted sequencing of laser capture micro-dissected lesion and blood DNA, and identified a somatic, activating GNA14 mutation specific to the tumor. Read More

View Article and Full-Text PDF
November 2019

A retrospective study: Clinicopathological and immunohistochemical analysis of 54 cases of tufted angioma.

Indian J Dermatol Venereol Leprol 2020 Jan-Feb;86(1):24-32

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shanxi Province, China.

Background: Tufted angioma is a rare benign lesion with vascular proliferation.

Aim: To retrospectively analyze the clinicopathological manifestations and immunohistochemical features of tufted angioma.

Methods: Clinical and histopathological features of tufted angioma (n = 54) were evaluated and analyzed retrospectively in the Department of Dermatology, Xijing Hospital from 2003 to 2014. Read More

View Article and Full-Text PDF

Tacrolimus ointment for the treatment of superficial kaposiform hemangioendothelioma and tufted angioma.

J Dermatol 2019 Oct 2;46(10):898-901. Epub 2019 Aug 2.

Division of Oncology, Department of Pediatric Surgery, West China Hospital of Sichuan University, Chengdu, China.

Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are rare infiltrative vascular tumors. Currently, no standard treatment regimens exist for KHE/TA. The purpose of our study was to evaluate the efficacy and safety of topical application of tacrolimus for superficial KHE/TA. Read More

View Article and Full-Text PDF
October 2019

Ultrasonography and magnetic resonance imaging features of kaposiform hemangioendothelioma and tufted angioma.

J Dermatol 2019 Oct 2;46(10):835-842. Epub 2019 Aug 2.

Department of, Ultrasound, School of Medicine, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) primarily occurring in infants are difficult to distinguish. This study evaluated ultrasonography (US) and magnetic resonance imaging (MRI) features of KHE and TA. Pathologically proven TA (n = 21) and KHE (n = 40 [11 KHE + Kasabach-Merritt phenomenon [KMP]]) occurring between January 2015 and December 2017 were reviewed. Read More

View Article and Full-Text PDF
October 2019

Topical timolol maleate for treatment of tufted angioma.

J Dermatol 2019 Nov 27;46(11):e402-e403. Epub 2019 Jun 27.

Department of Dermatology, Beijing Children's Hospital, Capital Medical University (National Center for Children's Health, China), Beijing, China.

View Article and Full-Text PDF
November 2019

Low dose sirolimus treatment for refractory tufted angioma and congenital kaposiform hemangioendothelioma, both with Kasabach-Merritt phenomenon.

Pediatr Blood Cancer 2019 08 14;66(8):e27810. Epub 2019 May 14.

Dermatology Service, Irmandade da Santa Casa de Misericórdia de Porto Alegre, Porto Alegre, Brazil.

View Article and Full-Text PDF

Pediatric facial kaposiform hemangioendothelioma: a case report and review of the literature.

J Surg Case Rep 2019 Apr 27;2019(4):rjz113. Epub 2019 Apr 27.

Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, OH, USA.

Cutaneous kaposiform hemangioendothelioma (KHE) and tufted angioma (TA) are vascular tumors that are often misdiagnosed. Treatment urgency and type varies depending on which tumor-type is diagnosed, because of the differing rates of progression to Kasabach-Merritt phenomenon. An 11-month-old male presented with a facial mass and biopsy results favoring a diagnosis of TA. Read More

View Article and Full-Text PDF

Surgical excision of a tufted angioma of the hand in an adult-a rare case report with a review of literature.

AME Case Rep 2019 14;3. Epub 2019 Mar 14.

Department of General and Thoracic Surgery, General and Thoracic Surgery Unit, S. Anna Hospital, University of Ferrara, Ferrara, Italy.

Tufted Angiomas, also known as angioblastomas/Angioblastoma of Nagakawa, are rare vascular neoplasms of both sexes localised to the skin and subcutaneous tissues with the upper trunk and neck being the most common sites. They are more common in children but a few cases in juveniles and adults have been reported. Typically, Tufted Angioma remains stable or can show rarely a spontaneous regression. Read More

View Article and Full-Text PDF

Indurated Dusky Red Swelling on the Forearm of an Infant: Tufted Angioma.

Indian J Dermatol 2019 Mar-Apr;64(2):146-148

Department of Pathology, University College of Medical Sciences and GTB Hospital (University of Delhi), New Delhi, India.

Tufted angioma (TA) is a rare benign vascular tumor that may be congenital or acquired and generally presents as an asymptomatic or painful solitary erythematous to violaceous poorly defined plaque. Hyperhidrosis and hypertrichosis may be associated. The lesions have tendency to resolve spontaneously, in majority, within 2 years of disease onset. Read More

View Article and Full-Text PDF

Tufted-angioma-like lesion associated with vascular endothelial growth factor and interleukin-6 in TAFRO syndrome: Is it a common histological feature of multicentric Castleman disease/POEMS syndrome?

J Cutan Pathol 2019 Apr 6;46(4):280-284. Epub 2019 Feb 6.

Department of General Medicine, Tenri Hospital, Nara, Japan.

The histology of skin lesions of TAFRO (thrombocytopenia, anasarca, reticulin fibrosis/renal failure, and organomegaly) syndrome has rarely been reported. We report herein two cases of TAFRO syndrome with characteristic vascular skin lesions. The lesions resembled a tufted angioma, although those of case 1 partially resembled a glomeruloid hemangioma, which was known as a specific lesion in POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes), a variant of multicentric Castleman disease (MCD). Read More

View Article and Full-Text PDF

Comparison of Corticosteroid and Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma: A Systematic Review and Meta-Analysis.

Eur J Pediatr Surg 2019 Oct 29;29(5):401-407. Epub 2018 Oct 29.

Department of Pediatric Surgery, Children's Hospital of Fudan University, Shanghai, People's Republic of China.

Objective:  To evaluate the outcome and safety of corticosteroids and vincristine (VCR) in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).

Materials And Methods:  Clinical studies involving corticosteroids and VCR therapies in treating KHE/TA were identified by using PubMed, Cochrane Library, OVID, EBSCO, CNKI, VIP, and Wanfang databases from their establishment date to December 2017. Randomized controlled trials, case-control, or case series with more than five cases were included. Read More

View Article and Full-Text PDF
October 2019