Search our Database of Scientific Publications and Authors

I’m looking for a

    181 results match your criteria Tufted Angioma

    1 OF 4

    The clinical spectrum of kaposiform hemangioendothelioma and tufted angioma.
    Semin Cutan Med Surg 2016 Sep;35(3):147-52
    Department of Pediatrics, Division of Dermatology, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, Washington, USA.
    Kasposiform hemoangioendothelioma (KHE) and tufted angioma (TA) are classifed as vascular tumors with locally aggressive and benign growth potential, respectively, within the classification schema proposed by the International Society for the Study of Vascular Anomalies. A unique feature of these vascular tumors is the risk of Kasabach-Merritt phenomenon (KMP), a severe thrombocytopenia with mild to moderate coagulopathy resulting from intralesional platelet trapping. As with many vascular anomalies, accurate description of clinical course, responses to therapy, and long-term outcomes have been hindered by lesion misidentification, imprecise nomenclature, and lack of prospective, randomized clinical trials to assess therapeutic efficacy. Read More

    Tufted Angioma of Eyelid in an Adult - A Case Report.
    J Clin Diagn Res 2016 Jun 1;10(6):ED12-3. Epub 2016 Jun 1.
    Director and Professor, Department of Ophthalmology, Regional Institute of Ophthalmology, M.L.N. Medical College , Allahabad, U.P., India .
    Tufted Angiomas also known as angioblastomas /Angioblastoma of Nagakawa are rare vascular neoplasms localised to the skin and subcutaneous tissues with the upper trunk and neck being most common sites. They are mainly seen in children but a few cases in juveniles and adults have been reported. We hereby report this case, a 40-year-old male who presented with a right lower lid, painless, slowly progressive, firm swelling diagnosed as Tufted Angioma on histopathology and immunohistochemistry. Read More

    Treatment of kaposiform hemangioendothelioma and tufted angioma.
    Int J Cancer 2016 Oct 28;139(7):1658-66. Epub 2016 Jun 28.
    College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    This meta-analysis was to evaluate the efficacy of current treatment modalities for kaposiform hemangioendothelioma and tufted angioma. A systematic review was performed using PubMed (Medline), Web of Science and Embase for clinical studies. The outcome was measured by pooled response rate with 95% confidence intervals (CIs), together with heterogeneity, subgroup analysis, sensitivity analysis and publication bias. Read More

    Clinical Outcomes for Systemic Corticosteroids Versus Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma.
    Medicine (Baltimore) 2016 May;95(20):e3431
    From the Department of Oral Surgery (XL, CY, SZ); and Department of Oral-Maxillofacial Head and Neck Surgery (JZ, LZ), Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China; Key Laboratory of Orthopedic Implant (XQ), Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Jining Medical University (JL), Jining, Shandong Province; Pudong Institute of Preventive Medicine (WY), Fudan University, Shanghai, China.
    A meta-analysis was performed to evaluate the efficacy and safety of systemic corticosteroids versus those of vincristine in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).A literature search of PubMed, Embase, and Web of Science was performed for clinical studies on systemic corticosteroid versus vincristine therapies in treating KHE/TA. Pooled relative risks (RRs) and response rate with 95% confidence intervals (CIs) were used to measure outcomes. Read More

    [Clinicopathologic study of pediatric vascular anomalies: a report of 117 cases].
    Zhonghua Bing Li Xue Za Zhi 2016 Apr;45(4):252-7
    Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
    Objective: To study the clinicopathologic features of pediatric vascular anomalies and application of ISSVA classification.

    Methods: The clinical features, histopathologic findings and immunohistochemical results were analyzed in 117 cases of pediatric vascular anomalies encountered during the period from May 2014 to May 2015.

    Results: A total of 117 cases of vascular anomalies were studied. Read More

    Port-Wine Stain-Like Presentation of a Tufted Angioma on the Face.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e166-7
    Department of Pediatrics, Children's Hospital at London Health Science Centre, Western University, London, ON, Canada.
    Tufted angioma is an uncommon benign vascular tumor that typically is noted during infancy or childhood, with variable clinical presentation. We report the case of an infant with a tufted angioma initially presenting as a port-wine stain-like patch of the left cheek. Read More

    A Critical Analysis of Eleven Periocular Lobular Capillary Hemangiomas in Adults.
    Am J Ophthalmol 2016 May 10;165:164-73. Epub 2016 Mar 10.
    David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye & Ear Infirmary; and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Purpose: To provide a critical analysis of a series of periocular lobular capillary hemangiomas in adults, outlining characteristic clinical and histopathologic patterns in comparison with those of other vascular tumors of adults and children.

    Design: Retrospective observational case series.

    Methods: Review of clinical data, hematoxylin-eosin-stained sections, and immunohistochemical studies of smooth muscle actin (SMA), D2-40, CD34, and glucose transporter 1 (GLUT-1). Read More

    Tufted angioma of the maxilla: a rare case with unique clinical presentation.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Sep 19;122(3):e93-8. Epub 2015 Dec 19.
    Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
    Tufted angioma is an uncommon benign vascular tumor usually presenting in early childhood and affecting mainly the skin. It has been associated with Kasabach-Merritt syndrome, a severe coagulopathy of poor prognosis. There have been very few published cases of oral tufted angiomas, and maxillary bone involvement has not been hitherto reported. Read More

    [Clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma in children].
    Zhonghua Bing Li Xue Za Zhi 2015 Jul;44(7):495-8
    Department of Pathology, Jiangxi Children's Hospital, Nanchang 330006, China; E-mail:
    Objective: To investigate the clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma (NICH) in children.

    Methods: The clinical, morphologic and immunophenotypic characteristics of 22 cases of NICH were retrospectively analyzed.

    Results: The mean patients' age at diagnosis was 4. Read More

    Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy.
    JAMA Dermatol 2015 Nov;151(11):1240-3
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut2Department of Pathology, Yale University School of Medicine, New Haven, Connecticut3Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
    Importance: Inhibition of angiogenesis is an effective anticancer strategy because neoplasms require a rich blood supply. Ramucirumab, approved by the US Food and Drug Administration in 2014 to treat gastric adenocarcinomas and non-small cell lung carcinomas, targets vascular endothelial growth factor 2 (VEGFR2). We identified a patient prescribed a regimen of irinotecan hydrochloride, cetuximab, and ramucirumab for metastatic rectal cancer (diagnosed in November 2013 and treated through early January 2015) who developed a new-onset, expanding vascular lesion on his right leg. Read More

    A case of acquired tufted angioma in adulthood.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):16-8
    Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, IT.
    Tufted angioma is a rare vascular tumor whose name derives from its histopathological appearance, characterized by tufts of capillaries within the dermis. Its etiology and pathogenesis are uncertain. Tufted angioma typically occurs during infancy or early childhood and displays various clinical patterns. Read More

    Multifocal Annular Tufted Angioma: An Uncommon Clinical Entity.
    Indian J Dermatol 2015 Jul-Aug;60(4):422
    Department of Dermatology, Venereology, and Leprosy, Medical College, Kolkata, West Bengal, India.
    Tufted angioma (TA) is a localized benign hamartomatous vascular proliferation usually presenting in the childhood as an erythematous plaque. We report here a rare case of multifocal TA in an 8-year-old boy who presented which two large annular lesions as well as multiple papules and nodules on the back for the duration of 4 years. Histology showed typical well circumscribed poorly canalized vascular lobules with 'cannon ball' configuration. Read More

    A tufted angioma.
    Indian Dermatol Online J 2015 Jul-Aug;6(4):266-8
    Department of Dermatology, Comprehensive Dermatology Centre, Hyderabad, Andhra Pradesh, India.
    Tufted angioma (TA) is a rare, benign, cutaneous angiomatous proliferation. It is more common in children, usually presenting as red-purple painful plaques on the trunk. We describe here a TA observed at nine months of age, appearing initially over the retroauricular area, gradually extending to involve skin of neck and trunk by two years of age. Read More

    Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon.
    Br J Haematol 2015 Oct 30;171(1):38-51. Epub 2015 Jun 30.
    Department of Haematology, Our Lady's Children's Hospital, Dublin, Ireland.
    Kasabach-Merritt Phenomenon (KMP) refers to the clinical constellation of thrombocytopenia, consumptive coagulopathy and purpura associated with Kaposiform haemangioedothelioma or tufted angioma, but not the more common infantile haemangioma. It shows a variable and unpredictable response to traditional pharmacological agents, such as steroids, vincristine or interferon alpha 2a or 2b. More recently, the interaction between platelets and endothelial cells and the proangiogenic phenotype that results has been recognized to underly the pathogenesis of this disorder. Read More

    [Is alfa-interferon still current in the management of Kasabach-Merritt syndrome?].
    Arch Pediatr 2015 May 6;22(5):523-7. Epub 2015 Apr 6.
    Unité protégée, institut d'hématologie et d'oncologie pédiatrique, centre Léon-Berard, Lyon, France.
    Kasabach-Merritt syndrome (KMS), characterized by thrombocytopenia, may complicate vascular tumors such as kaposiform hemangioendothelioma and tufted angioma. We report on two infants, respectively 2 months and 15 days old at the onset of symptoms, the first of whom presented with a left cervico-occipito-scapular hemangioma with parotid extension, and the second with a vascular tumor located on the left shoulder with fast extension on the left inferior hemithorax and the left arm. Thrombocytopenia (< 20 G/L) was associated in both cases. Read More

    The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon.
    Dermatol Pract Concept 2015 Jan 30;5(1):91-3. Epub 2015 Jan 30.
    Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, Sevilla, Spain.
    Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (TA). Typical features also include low fibrinogen and elevated D-dimers. It is well known that KMP is not caused by infantile hemangiomas. Read More

    [Tufted angiomas in childhood: A series of 9 cases and a literature review].
    An Pediatr (Barc) 2015 Sep 24;83(3):201-8. Epub 2014 Nov 24.
    Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
    Introduction: Tufted angioma (TA) is a rare benign vascular tumor that mostly appears during infancy or early childhood, although there are cases reported in adults. Clinical presentation and evolution of TA can vary. Histologically, it takes on a classic appearance of vascular tufts ("cannon ball" like appearance). Read More

    Tufted angioma with Kasabach-Merritt syndrome mistaken for child abuse.
    Forensic Sci Int 2014 Dec 14;245:e15-7. Epub 2014 Oct 14.
    Rennes University Hospital, Department of Forensic Medicine, 2 rue Henri Le Guilloux, 35033 Rennes Cedex 9, France; University of Rennes 1, Faculty of Medicine, 2, avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
    We report the case of a 2-month-old infant with a single apparently ecchymotic lesion on the shoulder that raised suspicions of abuse. The medicolegal examination concluded that the appearance of the lesion was only mildly suggestive of an ecchymosis. A second, temporally remote examination confirmed this doubt. Read More

    Tufted angioma in children: report of two cases and a review of the literature.
    Case Rep Dent 2014 4;2014:942489. Epub 2014 Nov 4.
    Department of Oral Pathology, Federal University of Rio Grande do Sul, Room 503, Rua Ramiro Barcelos 2492, 90035-003 Porto Alegre, RS, Brazil.
    Tufted angioma (TA) is a benign vascular tumor with endothelial origin. It is extremely rare in oral mucosa; only seven cases have been reported in the literature so far. Here, we describe two cases of tufted angioma observed in children and we also present a review of the literature about this pathology, concerning the differential diagnosis and management of this lesion in children. Read More

    Adult-onset tufted angiomas associated with an arteriovenous malformation in a renal transplant recipient: case report and review of the literature.
    Am J Dermatopathol 2015 Feb;37(2):162-5
    *Dermatology, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; †Dermatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; ‡Department of Molecular Medicine, University of Pavia, Pavia, Italy; §Pathology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; and ¶Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    Tufted angioma (TA) is a rare benign vascular neoplasm characterized histopathologically by the proliferation of endothelial cells arranged in lobules in the dermis and subcutaneous fat. To date, about 200 cases have been reported, most of which are of Japanese ethnicity. TA predominantly affects children and young adults, developing in 80% of patients younger than 10 years. Read More

    Treating kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon by intralesional injection of absolute ethanol.
    J Craniofac Surg 2014 Nov;25(6):2188-91
    From the *Third Affiliated Hospital of Soochow University, Changzhou, China; and †Department of Plastic Surgery, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
    Purpose: Kasabach-Merritt phenomenon (KMP) is characterized by thrombocytopenia, microangiopathic hemolytic anemia, consumptive coagulopathy, and an enlarging vascular lesion. It is a rare and life-threatening disease of vascular tumor. The purpose of this study was to assess the effectiveness of absolute ethanol in the treatment of KMP. Read More

    Clinical observations in mesh suture treatment for infants of Kasabach-Merritt phenomenon.
    J Paediatr Child Health 2014 Oct 15. Epub 2014 Oct 15.
    Department of Hemangioma Characteristic, LinYi Tumor Hospital, Linyi, China.
    Aim: This study aims to evaluate the efficacy and adverse effects of the mesh suture treatment for infants of Kasabach-Merritt phenomenon and to report our treatment experience.

    Methods: Of the three patients, two of the cases occurred in the scalp and one occurred in the back of the chest, with platelet counts < 40 × 10(9) /L before the treatment, reduced fibrinogen levels and increased D-dimer levels. All the three patients underwent the mesh suture treatment of the tumour area. Read More

    Medical therapy for pediatric vascular anomalies.
    Semin Plast Surg 2014 May;28(2):79-86
    Division of Interventional Radiology, Department of Radiology, TCH, Baylor College of Medicine, Houston, Texas.
    Vascular anomalies (VAs) comprise a large variety of individual diagnoses that in different phases of treatment require a diverse number of medical specialists to provide optimal care. Medical therapies include agents usually associated with cancer chemotherapy, such as vincristine, as well more immunomodulatory types of drugs, such as glucocorticoids and sirolimus. These immunomodulating drugs are being successfully applied in cases that are typically categorized as vascular tumors, including kaposiform hemangioendothelioma (KHE) and tufted angioma (TA), as well as some of the more invasive types of vascular malformations (i. Read More

    Vascular tumours in infants. Part II: vascular tumours of intermediate malignancy [corrected] and malignant tumours.
    Br J Dermatol 2014 Sep 25;171(3):474-84. Epub 2014 Jun 25.
    Histopathology Department, Birmingham Children's Hospital, Birmingham, U.K.
    Malignant cutaneous vascular tumours are very uncommon in children. As in adults, they are aggressive neoplasms with metastatic potential and a high mortality rate. Some nonmalignant vascular tumours may exhibit a locally aggressive behaviour and some of them can be associated with life-threatening systemic complications such as Kasabach-Merritt syndrome. Read More

    Kasabach-Merritt phenomenon in an adult man with a tufted angioma and cirrhosis responding to radiation, bevacizumab, and prednisone.
    Int J Dermatol 2014 Sep 2;53(9):1165-76. Epub 2014 Apr 2.
    Departments of Dermatology and Anatomic Pathology, Cleveland Clinic, Cleveland, OH, USA.
    Background: Tufted angioma (TA) is a benign cutaneous vascular tumor that most commonly occurs in young children. TAs have rarely been reported in adults and/or arising within port-wine stains (PWS). Kasabach-Merritt phenomenon (KMP) is a life-threatening consumptive coagulopathy hypothesized to occur specifically in young children who develop either a TA or kaposiform hemangioendothelioma. Read More

    Tufted angioma in ear auricle: importance of the differential diagnosis.
    An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):113-5
    Universidade Federal de São Paulo.
    Tufted angioma is an acquired vascular proliferation with specific histological characteristics. The most common clinical features are erythematous macules. It occurs predominantly in children and young adults, especially in the chest and neck. Read More

    Tufted angioma (Angioblastoma) of eyelid in adults-report of two cases.
    Diagn Pathol 2013 Sep 17;8:153. Epub 2013 Sep 17.
    Dalmia Ophthalmic Pathology Services, L,V, Prasad Eye Institute, Bhubaneswar, Orissa, India.
    Unlabelled: Tufted angioma, first recognized in Japanese literature as "Angioblastoma of Nagakawa", is a rare benign vascular tumour with a variable clinical presentation. It commonly manifests as a macule, papule or nodule in infancy or childhood in the region of the upper trunk and neck. Here in we report two cases of this rare progressive angioma as lesions of the eyelid in adults. Read More

    Angiosarcoma associated with a Kasabach-Merritt syndrome: report of two cases treated with paclitaxel.
    Future Oncol 2013 Sep;9(9):1397-9
    Department of Medical Oncology, Institut Bergonié, Bordeaux, France.
    Angiosarcomas are rare, aggressive vascular malignancies of endothelial cell differentiation. Kasabach-Merritt syndrome is a rare condition defined by the association of thrombocytopenia and consumption coagulopathy with specific vascular tumors, such as tufted angioma or kaposiform hemangioendothelioma. We report here two cases of angiosarcomas complicated by a Kasabach-Merritt syndrome and their outcome after treatment with paclitaxel. Read More

    Medical management of tumors associated with Kasabach-Merritt phenomenon: an expert survey.
    J Pediatr Hematol Oncol 2013 Nov;35(8):618-22
    *Department of Dermatology †Department of Pediatrics ¶Departments of Dermatology and Pediatrics, Columbia University, New York, NY ‡Departments of Dermatology and Pediatrics, Medical College of Wisconsin and Children's Hospital of Wisconsin, Milwaukee, WI §Departments of Pediatrics and Dermatology, University of California San Francisco, San Francisco, CA ∥Department of Pediatrics Cincinnati Children's Hospital and University of Cincinnati, Cincinnati OH.
    Kasabach-Merritt phenomenon (KMP) is a rare consumptive coagulopathy characterized by profound thrombocytopenia and hypofibrinogenemia occurring in association with the vascular tumors kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). Treatment remains challenging without consensus on the optimal medical management. The authors compiled expert opinions regarding management to establish treatment recommendations. Read More

    Acquired capillary hemangioma with features of tufted angioma in the external auditory canal.
    J Craniofac Surg 2013 May;24(3):e270-1
    Department of Otolaryngology, Faculty of Medicine, Inonu University, Malatya, Turkey.
    Tufted angiomas may occur in the head and neck region, but the external auditory canal is a previously undefined localization. There are only 19 cases of hemangiomas reported in this unique localization. However, this case is the first capillary hemangioma of the tufted variant being reported with a recurrence after 7 years after surgical excision in a 47-year-old male patient. Read More

    Resection of a huge tufted angioma of orbit and orbitocranial mesh reconstruction.
    J Neurol Surg A Cent Eur Neurosurg 2013 Dec 22;74 Suppl 1:e193-7. Epub 2013 May 22.
    Department of Neurosurgery, GATA Haydarpasa, Ankara, Turkey.
    Background And Study Aims: Tufted angiomas (TAs) are rare, benign vascular neoplasms of childhood mainly localized in the skin and subcutaneous tissues. TAs are progressive, slowly growing, and characteristically involve superficial or deep muscle fascia tissue. TAs are frequently seen before the age of 5 years (60 to 70%) and have no sex predominance. Read More

    Long-term outcome of vincristine-aspirin-ticlopidine (VAT) therapy for vascular tumors associated with Kasabach-Merritt phenomenon.
    Pediatr Blood Cancer 2013 Sep 22;60(9):1478-81. Epub 2013 Apr 22.
    Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, Sevilla, Spain.
    Background: . This study aimed to clarify the combinatorial treatment effect of agents as aspirin and ticlopidine associated with vincristine in the management of Kasabach-Merritt phenomenon (KMP), a severe thrombocytopenic coagulopathy that occurs in the presence of an enlarging vascular tumor such as kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).

    Procedure: . Read More

    Acquired tufted angioma of upper lip: case report and review of the literature.
    Head Neck Pathol 2013 Sep 23;7(3):291-4. Epub 2013 Mar 23.
    Department of Oral Diagnostic Sciences, Advanced Oral and Maxillofacial Pathology Program, School of Dental Medicine, University at Buffalo, 355 Squire Hall, Buffalo, NY 14214, USA.
    Acquired tufted angioma is a rare, cutaneous and slow growing benign vascular neoplasm that usually affects pediatric populations. Only six cases of oral mucosal acquired tufted angioma have been reported in the English language literature. We present in this report the seventh case and discuss its clinical and pathological features. Read More

    An acquired tufted angioma of the nasal cavity.
    Auris Nasus Larynx 2013 Dec 18;40(6):581-3. Epub 2013 Mar 18.
    Department of Otorhinolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, South Korea.
    Tufted angiomas are benign vascular tumors that occur mainly in children younger than 5 years, involving the skin with subcutaneous plaques or in a nodular form. We experienced a rare tufted angioma in the nasal cavity. A 35-year-old woman visited our clinic because of frequent epistaxis. Read More

    Congenital disseminated tufted angioma.
    J Cutan Pathol 2013 Apr 4;40(4):405-8. Epub 2013 Feb 4.
    Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.
    Tufted angioma represents a rare vascular tumor that can develop in children and young adults. It usually presents as solitary plaque or large tumor on the extremities, trunk or other anatomic sites. Histopathologically, it is characterized by proliferation of closely packed capillaries in the dermis in a 'cannonball' distribution. Read More

    Medical management of vascular anomalies.
    Facial Plast Surg 2012 Dec 27;28(6):575-83. Epub 2012 Nov 27.
    Vascular Birthmark Institute of New York, New York, New York 10023, USA.
    The term "vascular anomalies" embraces a spectrum of medical conditions characterized by abnormal growth or development of blood and/or lymphatic vessels. Patient management is frequently provided in a multidisciplinary team approach, as there are many facets to evaluation and treatment. Clinical and basic research during the past decade has enhanced our knowledge, providing insight into possible etiologies, associated genetic mutations, cellular mechanisms modulating the development, and natural history of these disorders. Read More

    1 OF 4