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    Vascular Tumors in Infants: Case Report and Review of Clinical, Histopathologic, and Immunohistochemical Characteristics of Infantile Hemangioma, Pyogenic Granuloma, Noninvoluting Congenital Hemangioma, Tufted Angioma, and Kaposiform Hemangioendothelioma.
    Am J Dermatopathol 2018 Apr;40(4):231-239
    Professor, Department of Dermatology, Mayo Clinic, Rochester, MN.
    Vascular tumors in infants present a diagnostic and treatment dilemma for both clinicians and pathologists. Infantile hemangioma, the most common vascular tumor in infants, can be confused for other less common vascular tumors in infants. Correct and timely diagnosis is important, as some vascular tumors can be associated with life-threatening coagulopathy. Read More

    Immunoreactivity of Wilms tumor 1 (WT1) as an additional evidence supporting hemangiomatous rather than inflammatory origin in the etiopathogenesis of angiolymphoid hyperplasia with eosinophilia.
    Dermatol Pract Concept 2018 Jan 31;8(1):28-32. Epub 2018 Jan 31.
    Department of Dermatology Acibadem University School of Medicine, Istanbul, Turkey.
    Background: Angiolymphoid hyperplasia with eosinophilia (ALHE) is a rare vascular proliferative disorder mainly located in the periauricular region. The etiopathogenesis of ALHE is unknown, and it is still controversial as to whether the entity represents a benign vascular neoplasm or an inflammatory process.

    Aim: Recently, the intracytoplasmic staining pattern of Wilms tumor 1 (WT1) on immunohistochemistry has highlighted true vascular neoplasms, such as microvenular hemangioma, tufted angioma, and spindle cell hemangioma, which has made it helpful to distinguish ALHE from vascular malformations, as there is a negative staining pattern in the other entities. Read More

    Successful management of steroid-resistant vascular tumors associated with the Kasabach-Merritt phenomenon using sirolimus.
    J Dermatol 2018 May 21;45(5):580-583. Epub 2018 Jan 21.
    Guangzhou Women and Children's Medical Center, Guangzhou Medical University, China.
    Vascular tumors associated with Kasabach-Merritt phenomenon (KMP) are life-threatening and the mortality is as high as 10-30%. Steroids are considered the primary choice for drug therapy. However, there are many steroid-resistant cases. Read More

    Congenital Vascular Tumors.
    Otolaryngol Clin North Am 2018 Feb;51(1):89-97
    Department of Plastic and Oral Surgery, Vascular Anomalies Center, Boston Children's Hospital, Harvard Medical School, 300 Longwood Avenue Boston, MA, 02115, USA. Electronic address:
    Vascular tumors are benign neoplasms, which result from proliferating endothelial cells. These lesions present during infancy or childhood, may affect any location, and exhibit postnatal growth. Local complications include bleeding, tissue destruction, and pain whereas systemic sequelae include thrombocytopenia, congestive heart failure, and death. Read More

    Episode of Kasabach-Merritt phenomenon following Japanese encephalitis vaccination: Case report.
    Vaccine 2017 12 16;35(48 Pt B):6594-6597. Epub 2017 Oct 16.
    Department of Cardiac Surgery, The Children's Hospital of Zhejiang University School of Medicine, Zhejiang, China. Electronic address:
    Kasabach-Merritt phenomenon (KMP) is a rare potentially life-threatening consumptive coagulopathy characterized by thrombocytopenia and hypofibrinogenemia occurring associated with the vascular tumors kaposiform hemangioendothelioma (KHE) and tufted angioma (TA). A 10-month old male infant, diagnosed with KHE on his left leg, underwent a rapid increase of the lesion and severe thrombocytopenia, one day after the first dose of inactivated Japanese encephalitis (JE) vaccination. The episode of KMP was treated successfully by steroid. Read More

    Clinical and sonographic features of pediatric soft-tissue vascular anomalies part 1: classification, sonographic approach and vascular tumors.
    Pediatr Radiol 2017 Aug 4;47(9):1184-1195. Epub 2017 Aug 4.
    Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave., Toronto, ON, M5G 1X8, Canada.
    Sonography can be used in the management of pediatric soft-tissue vascular anomalies for diagnosing, for assessing lesion extent and for evaluating complications and response to therapy. The sonographic technique includes a combination of gray-scale imaging with color and spectral Doppler techniques. However the interpretation of the sonographic findings requires correlation with the clinical findings, some of which can be easily obtained at the time of scanning. Read More

    Multimodal treatment of Kasabach-Merritt syndrome arising from tufted angioma: A case report.
    Oncol Lett 2017 Jun 20;13(6):4887-4891. Epub 2017 Apr 20.
    Department of Reconstructive Plastic Surgery, The Children's Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China.
    Kasabach-Merritt syndrome (KMS) is a rare type of vascular tumor associated with a severely decreased platelet count. No standard guidelines for the treatment of the disease have been established so far. In the present study, a 1-year-old pediatric patient with KMS arising from tufted angioma was successfully and variously treated with steroids, vincristine, surgery and propranolol for 18 months. Read More

    Kasabach-Merritt Phenomenon: Classic Presentation and Management Options.
    Clin Med Insights Blood Disord 2017 16;10:1179545X17699849. Epub 2017 Mar 16.
    Department of Pediatrics, Baylor College of Medicine, Vascular Anomalies Center at Texas Children's Cancer and Hematology Centers, Texas Children's Hospital, Houston, TX, USA.
    Kasabach-Merritt phenomenon (KMP) is a rare consumptive coagulopathy associated with specific vascular tumors, kaposiform hemangioendothelioma, and tufted angioma. Kasabach-Merritt phenomenon, characterized by profound thrombocytopenia, hypofibrinogenemia, elevated fibrin split products, and rapid tumor growth, can be life-threatening. Severe symptomatic anemia may also be present. Read More

    Histopathology of Spindle Cell Vascular Tumors.
    Surg Pathol Clin 2017 Jun 31;10(2):345-366. Epub 2017 Mar 31.
    Department of Pathology, Cleveland Clinic, 9500 Euclid Avenue, L25, Cleveland, OH 44195, USA. Electronic address:
    Vascular tumors with a spindled morphology represent a diagnostic challenge in soft tissue pathology. It may be difficult to distinguish certain benign entities in this category from spindled vascular tumors of intermediate malignancy or even spindled variants of angiosarcoma. This article focuses on vascular tumors characterized by a predominantly spindled morphology, including spindle cell hemangioma, acquired tufted angioma (angioblastoma of Nakagawa), kaposiform hemangioendothelioma, Kaposi sarcoma, and spindle cell variants of angiosarcoma. Read More

    Kaposiform haemangioendothelioma: a review with emphasis on histological differential diagnosis.
    Pathology 2017 Jun 21;49(4):356-362. Epub 2017 Apr 21.
    Department of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States.
    Kaposiform haemangioendothelioma (KHE) is a rare, locally aggressive/borderline vascular tumour primarily seen in neonates and children. KHE is occasionally associated with Kasabach-Merritt phenomenon and tends to have a poor clinical prognosis. While the histological features of tufted angiomas and KHE overlap, some believe tufted angiomas are a milder, benign, more localised counterpart of KHE. Read More

    Intracranial intraaxial cerebral tufted angioma: case report.
    J Neurosurg 2018 Feb 24;128(2):524-529. Epub 2017 Feb 24.
    Departments of 1 Neurological Surgery.
    Tufted angioma (TA) is a rare, slow-growing, vascular lesion that commonly presents as a solitary macule, papule, or nodule arising in the soft tissues of the torso, extremities, and head and neck in children and young adults. Adult-onset cases have been infrequently reported. While typically benign, TAs may be locally aggressive. Read More

    The clinical spectrum of kaposiform hemangioendothelioma and tufted angioma.
    Semin Cutan Med Surg 2016 Sep;35(3):147-52
    Department of Pediatrics, Division of Dermatology, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, Washington, USA.
    Kasposiform hemoangioendothelioma (KHE) and tufted angioma (TA) are classifed as vascular tumors with locally aggressive and benign growth potential, respectively, within the classification schema proposed by the International Society for the Study of Vascular Anomalies. A unique feature of these vascular tumors is the risk of Kasabach-Merritt phenomenon (KMP), a severe thrombocytopenia with mild to moderate coagulopathy resulting from intralesional platelet trapping. As with many vascular anomalies, accurate description of clinical course, responses to therapy, and long-term outcomes have been hindered by lesion misidentification, imprecise nomenclature, and lack of prospective, randomized clinical trials to assess therapeutic efficacy. Read More

    Tufted Angioma of Eyelid in an Adult - A Case Report.
    J Clin Diagn Res 2016 Jun 1;10(6):ED12-3. Epub 2016 Jun 1.
    Director and Professor, Department of Ophthalmology, Regional Institute of Ophthalmology, M.L.N. Medical College , Allahabad, U.P., India .
    Tufted Angiomas also known as angioblastomas /Angioblastoma of Nagakawa are rare vascular neoplasms localised to the skin and subcutaneous tissues with the upper trunk and neck being most common sites. They are mainly seen in children but a few cases in juveniles and adults have been reported. We hereby report this case, a 40-year-old male who presented with a right lower lid, painless, slowly progressive, firm swelling diagnosed as Tufted Angioma on histopathology and immunohistochemistry. Read More

    Treatment of kaposiform hemangioendothelioma and tufted angioma.
    Int J Cancer 2016 10 28;139(7):1658-66. Epub 2016 Jun 28.
    College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
    This meta-analysis was to evaluate the efficacy of current treatment modalities for kaposiform hemangioendothelioma and tufted angioma. A systematic review was performed using PubMed (Medline), Web of Science and Embase for clinical studies. The outcome was measured by pooled response rate with 95% confidence intervals (CIs), together with heterogeneity, subgroup analysis, sensitivity analysis and publication bias. Read More

    Clinical Outcomes for Systemic Corticosteroids Versus Vincristine in Treating Kaposiform Hemangioendothelioma and Tufted Angioma.
    Medicine (Baltimore) 2016 May;95(20):e3431
    From the Department of Oral Surgery (XL, CY, SZ); and Department of Oral-Maxillofacial Head and Neck Surgery (JZ, LZ), Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China; Key Laboratory of Orthopedic Implant (XQ), Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Jining Medical University (JL), Jining, Shandong Province; Pudong Institute of Preventive Medicine (WY), Fudan University, Shanghai, China.
    A meta-analysis was performed to evaluate the efficacy and safety of systemic corticosteroids versus those of vincristine in the treatment of kaposiform hemangioendothelioma (KHE) and tufted angioma (TA).A literature search of PubMed, Embase, and Web of Science was performed for clinical studies on systemic corticosteroid versus vincristine therapies in treating KHE/TA. Pooled relative risks (RRs) and response rate with 95% confidence intervals (CIs) were used to measure outcomes. Read More

    [Clinicopathologic study of pediatric vascular anomalies: a report of 117 cases].
    Zhonghua Bing Li Xue Za Zhi 2016 Apr;45(4):252-7
    Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.
    Objective: To study the clinicopathologic features of pediatric vascular anomalies and application of ISSVA classification.

    Methods: The clinical features, histopathologic findings and immunohistochemical results were analyzed in 117 cases of pediatric vascular anomalies encountered during the period from May 2014 to May 2015.

    Results: A total of 117 cases of vascular anomalies were studied. Read More

    Port-Wine Stain-Like Presentation of a Tufted Angioma on the Face.
    Pediatr Dermatol 2016 Mar-Apr;33(2):e166-7
    Department of Pediatrics, Children's Hospital at London Health Science Centre, Western University, London, ON, Canada.
    Tufted angioma is an uncommon benign vascular tumor that typically is noted during infancy or childhood, with variable clinical presentation. We report the case of an infant with a tufted angioma initially presenting as a port-wine stain-like patch of the left cheek. Read More

    A Critical Analysis of Eleven Periocular Lobular Capillary Hemangiomas in Adults.
    Am J Ophthalmol 2016 May 10;165:164-73. Epub 2016 Mar 10.
    David G. Cogan Ophthalmic Pathology Laboratory, Massachusetts Eye & Ear Infirmary; and the Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address:
    Purpose: To provide a critical analysis of a series of periocular lobular capillary hemangiomas in adults, outlining characteristic clinical and histopathologic patterns in comparison with those of other vascular tumors of adults and children.

    Design: Retrospective observational case series.

    Methods: Review of clinical data, hematoxylin-eosin-stained sections, and immunohistochemical studies of smooth muscle actin (SMA), D2-40, CD34, and glucose transporter 1 (GLUT-1). Read More

    Tufted angioma of the maxilla: a rare case with unique clinical presentation.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Sep 19;122(3):e93-8. Epub 2015 Dec 19.
    Department of Oral Medicine and Pathology, School of Dentistry, National and Kapodistrian University of Athens, Athens, Greece.
    Tufted angioma is an uncommon benign vascular tumor usually presenting in early childhood and affecting mainly the skin. It has been associated with Kasabach-Merritt syndrome, a severe coagulopathy of poor prognosis. There have been very few published cases of oral tufted angiomas, and maxillary bone involvement has not been hitherto reported. Read More

    [Clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma in children].
    Zhonghua Bing Li Xue Za Zhi 2015 Jul;44(7):495-8
    Department of Pathology, Jiangxi Children's Hospital, Nanchang 330006, China; E-mail:
    Objective: To investigate the clinicopathologic features and differential diagnoses of non-involuting congenital hemangioma (NICH) in children.

    Methods: The clinical, morphologic and immunophenotypic characteristics of 22 cases of NICH were retrospectively analyzed.

    Results: The mean patients' age at diagnosis was 4. Read More

    Somatic p.T771R KDR (VEGFR2) Mutation Arising in a Sporadic Angioma During Ramucirumab Therapy.
    JAMA Dermatol 2015 Nov;151(11):1240-3
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut2Department of Pathology, Yale University School of Medicine, New Haven, Connecticut3Department of Genetics, Yale University School of Medicine, New Haven, Connecticut.
    Importance: Inhibition of angiogenesis is an effective anticancer strategy because neoplasms require a rich blood supply. Ramucirumab, approved by the US Food and Drug Administration in 2014 to treat gastric adenocarcinomas and non-small cell lung carcinomas, targets vascular endothelial growth factor 2 (VEGFR2). We identified a patient prescribed a regimen of irinotecan hydrochloride, cetuximab, and ramucirumab for metastatic rectal cancer (diagnosed in November 2013 and treated through early January 2015) who developed a new-onset, expanding vascular lesion on his right leg. Read More

    A case of acquired tufted angioma in adulthood.
    An Bras Dermatol 2015 May-Jun;90(3 Suppl 1):16-8
    Ospedale Maggiore Policlinico, Fondazione IRCCS Ca' Granda, Milan, IT.
    Tufted angioma is a rare vascular tumor whose name derives from its histopathological appearance, characterized by tufts of capillaries within the dermis. Its etiology and pathogenesis are uncertain. Tufted angioma typically occurs during infancy or early childhood and displays various clinical patterns. Read More

    Multifocal Annular Tufted Angioma: An Uncommon Clinical Entity.
    Indian J Dermatol 2015 Jul-Aug;60(4):422
    Department of Dermatology, Venereology, and Leprosy, Medical College, Kolkata, West Bengal, India.
    Tufted angioma (TA) is a localized benign hamartomatous vascular proliferation usually presenting in the childhood as an erythematous plaque. We report here a rare case of multifocal TA in an 8-year-old boy who presented which two large annular lesions as well as multiple papules and nodules on the back for the duration of 4 years. Histology showed typical well circumscribed poorly canalized vascular lobules with 'cannon ball' configuration. Read More

    A tufted angioma.
    Indian Dermatol Online J 2015 Jul-Aug;6(4):266-8
    Department of Dermatology, Comprehensive Dermatology Centre, Hyderabad, Andhra Pradesh, India.
    Tufted angioma (TA) is a rare, benign, cutaneous angiomatous proliferation. It is more common in children, usually presenting as red-purple painful plaques on the trunk. We describe here a TA observed at nine months of age, appearing initially over the retroauricular area, gradually extending to involve skin of neck and trunk by two years of age. Read More

    Recent advances in the pathobiology and management of Kasabach-Merritt phenomenon.
    Br J Haematol 2015 Oct 30;171(1):38-51. Epub 2015 Jun 30.
    Department of Haematology, Our Lady's Children's Hospital, Dublin, Ireland.
    Kasabach-Merritt Phenomenon (KMP) refers to the clinical constellation of thrombocytopenia, consumptive coagulopathy and purpura associated with Kaposiform haemangioedothelioma or tufted angioma, but not the more common infantile haemangioma. It shows a variable and unpredictable response to traditional pharmacological agents, such as steroids, vincristine or interferon alpha 2a or 2b. More recently, the interaction between platelets and endothelial cells and the proangiogenic phenotype that results has been recognized to underly the pathogenesis of this disorder. Read More

    [Is alfa-interferon still current in the management of Kasabach-Merritt syndrome?].
    Arch Pediatr 2015 May 6;22(5):523-7. Epub 2015 Apr 6.
    Unité protégée, institut d'hématologie et d'oncologie pédiatrique, centre Léon-Berard, Lyon, France.
    Kasabach-Merritt syndrome (KMS), characterized by thrombocytopenia, may complicate vascular tumors such as kaposiform hemangioendothelioma and tufted angioma. We report on two infants, respectively 2 months and 15 days old at the onset of symptoms, the first of whom presented with a left cervico-occipito-scapular hemangioma with parotid extension, and the second with a vascular tumor located on the left shoulder with fast extension on the left inferior hemithorax and the left arm. Thrombocytopenia (< 20 G/L) was associated in both cases. Read More

    The importance of early diagnosis and treatment of kaposiform hemangioendothelioma complicated by Kasabach-Merritt phenomenon.
    Dermatol Pract Concept 2015 Jan 30;5(1):91-3. Epub 2015 Jan 30.
    Department of Pediatric Surgery, Virgen del Rocio Children's Hospital, Sevilla, Spain.
    Kaposiform hemangioendothelioma (KHE) is a locally aggressive vascular tumor that may be complicated by Kasabach-Merritt phenomenon (KMP), a profound thrombocytopenia resulting from platelet trapping within a vascular tumor, either KHE or tufted angioma (TA). Typical features also include low fibrinogen and elevated D-dimers. It is well known that KMP is not caused by infantile hemangiomas. Read More

    [Tufted angiomas in childhood: A series of 9 cases and a literature review].
    An Pediatr (Barc) 2015 Sep 24;83(3):201-8. Epub 2014 Nov 24.
    Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
    Introduction: Tufted angioma (TA) is a rare benign vascular tumor that mostly appears during infancy or early childhood, although there are cases reported in adults. Clinical presentation and evolution of TA can vary. Histologically, it takes on a classic appearance of vascular tufts ("cannon ball" like appearance). Read More

    Tufted angioma with Kasabach-Merritt syndrome mistaken for child abuse.
    Forensic Sci Int 2014 Dec 14;245:e15-7. Epub 2014 Oct 14.
    Rennes University Hospital, Department of Forensic Medicine, 2 rue Henri Le Guilloux, 35033 Rennes Cedex 9, France; University of Rennes 1, Faculty of Medicine, 2, avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
    We report the case of a 2-month-old infant with a single apparently ecchymotic lesion on the shoulder that raised suspicions of abuse. The medicolegal examination concluded that the appearance of the lesion was only mildly suggestive of an ecchymosis. A second, temporally remote examination confirmed this doubt. Read More

    Tufted angioma in children: report of two cases and a review of the literature.
    Case Rep Dent 2014 4;2014:942489. Epub 2014 Nov 4.
    Department of Oral Pathology, Federal University of Rio Grande do Sul, Room 503, Rua Ramiro Barcelos 2492, 90035-003 Porto Alegre, RS, Brazil.
    Tufted angioma (TA) is a benign vascular tumor with endothelial origin. It is extremely rare in oral mucosa; only seven cases have been reported in the literature so far. Here, we describe two cases of tufted angioma observed in children and we also present a review of the literature about this pathology, concerning the differential diagnosis and management of this lesion in children. Read More

    Adult-onset tufted angiomas associated with an arteriovenous malformation in a renal transplant recipient: case report and review of the literature.
    Am J Dermatopathol 2015 Feb;37(2):162-5
    *Dermatology, Department of Clinical-Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy; †Dermatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; ‡Department of Molecular Medicine, University of Pavia, Pavia, Italy; §Pathology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy; and ¶Centre for Inherited Cardiovascular Diseases, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
    Tufted angioma (TA) is a rare benign vascular neoplasm characterized histopathologically by the proliferation of endothelial cells arranged in lobules in the dermis and subcutaneous fat. To date, about 200 cases have been reported, most of which are of Japanese ethnicity. TA predominantly affects children and young adults, developing in 80% of patients younger than 10 years. Read More

    Treating kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon by intralesional injection of absolute ethanol.
    J Craniofac Surg 2014 Nov;25(6):2188-91
    From the *Third Affiliated Hospital of Soochow University, Changzhou, China; and †Department of Plastic Surgery, Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
    Purpose: Kasabach-Merritt phenomenon (KMP) is characterized by thrombocytopenia, microangiopathic hemolytic anemia, consumptive coagulopathy, and an enlarging vascular lesion. It is a rare and life-threatening disease of vascular tumor. The purpose of this study was to assess the effectiveness of absolute ethanol in the treatment of KMP. Read More

    Clinical observations in mesh suture treatment for infants of Kasabach-Merritt phenomenon.
    J Paediatr Child Health 2014 Oct 15. Epub 2014 Oct 15.
    Department of Hemangioma Characteristic, LinYi Tumor Hospital, Linyi, China.
    Aim: This study aims to evaluate the efficacy and adverse effects of the mesh suture treatment for infants of Kasabach-Merritt phenomenon and to report our treatment experience.

    Methods: Of the three patients, two of the cases occurred in the scalp and one occurred in the back of the chest, with platelet counts < 40 × 10 /L before the treatment, reduced fibrinogen levels and increased D-dimer levels. All the three patients underwent the mesh suture treatment of the tumour area. Read More

    Medical therapy for pediatric vascular anomalies.
    Semin Plast Surg 2014 May;28(2):79-86
    Division of Interventional Radiology, Department of Radiology, TCH, Baylor College of Medicine, Houston, Texas.
    Vascular anomalies (VAs) comprise a large variety of individual diagnoses that in different phases of treatment require a diverse number of medical specialists to provide optimal care. Medical therapies include agents usually associated with cancer chemotherapy, such as vincristine, as well more immunomodulatory types of drugs, such as glucocorticoids and sirolimus. These immunomodulating drugs are being successfully applied in cases that are typically categorized as vascular tumors, including kaposiform hemangioendothelioma (KHE) and tufted angioma (TA), as well as some of the more invasive types of vascular malformations (i. Read More

    Vascular tumours in infants. Part II: vascular tumours of intermediate malignancy [corrected] and malignant tumours.
    Br J Dermatol 2014 Sep 25;171(3):474-84. Epub 2014 Jun 25.
    Histopathology Department, Birmingham Children's Hospital, Birmingham, U.K.
    Malignant cutaneous vascular tumours are very uncommon in children. As in adults, they are aggressive neoplasms with metastatic potential and a high mortality rate. Some nonmalignant vascular tumours may exhibit a locally aggressive behaviour and some of them can be associated with life-threatening systemic complications such as Kasabach-Merritt syndrome. Read More

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