Neurology 2022 03 31;98(12):e1216-e1225. Epub 2022 Jan 31.
From the Department of Pediatric Neurology, Brain Center (H.M.H., W.M.O., K.B., F.E.J.),* Image Sciences Institute (H.J.K.), Biomedical MR Imaging and Spectroscopy Group, Center for Image Sciences (W.M.O.), and Department of Radiology (M.H.L.), University Medical Center Utrecht, the Netherlands; Instytut Pomnik-Centrum Zdrowia Dziecka (K.K., K.S., S.J., E.J.), The Children's Memorial Health Institute,* Warsaw, Poland; Department of Pediatric Neuropsychiatry (P.C., A.B.), Tor Vergata University, Rome, Italy; Department of Neuropediatrics (B.W. C.H.), Charite-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universitat zu Berlin, Berlin Institute of Health (BIH), Germany; Neurosciences Unit (K.R.), Queensland Children's Hospital, Brisbane Australia and University of Queensland, Brisbane, Australia; Department of Pediatric Neurology (P.K., B.B.), Motol University Hospital, Prague, Czech Republic; Medizinische Universitaet Wien (M.F., T.S.),* Vienna, Austria; Department of Pediatric Neurology (R.N.), Necker Enfants Maladies Hospital,* Paris, France; Katholieke Universiteit (L.L., J.D.R.),* Leuven; Pediatric Neurology Unit (A.J.), Department of Pediatrics, UZ Brussel, Brussels, Belgium; Utrecht University (W.M.O.), the Netherlands; Transition Technologies (K.S.), Warsaw, Poland; Department of (Neuro)Pathology (E.M.A.A.), Amsterdam UMC, University of Amsterdam, Amsterdam Neuroscience; Stichting Epilepsie Instellingen Nederland (SEIN) (E.M.A.A.), Hoofddorp, the Netherlands; Brigham and Women's Hospital (D.J.K.), Harvard Medical School, Boston, MA; and Department of Child Neurology (S.J.), Medical University of Warsaw, Poland.
Background And Objectives: Multiple factors have been found to contribute to the high risk of epilepsy in infants with tuberous sclerosis complex (TSC), including evolution of EEG abnormalities, gene variant, and MRI characteristics. The aim of this prospective multicenter study was to identify early MRI biomarkers of epilepsy in infants with TSC aged <6 months and before seizure onset, and associate these MRI biomarkers with neurodevelopmental outcomes at 2 years of age. The study was part of the EPISTOP project. Read More