Radiol Imaging Cancer 2020 09 18;2(5):e190091. Epub 2020 Sep 18.
Department of Pediatric Neurology, Diakonie Kork, Kehl, Germany (C.R.); Department of Radiology (L.A.G., A.T.T., A.J.T.), Division of Neurology (D.A.K., D.N.F.), and Division of Biostatistics and Epidemiology (B.Z.), Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 5031, Cincinnati, OH 45229; and Departments of Radiology (A.T.T., A.J.T.) and Pediatrics (D.A.K., D.N.F., B.Z.), University of Cincinnati College of Medicine, Cincinnati, Ohio.
Purpose: To determine the effect of chronic mammalian target of rapamycin (mTOR) inhibition on skeletal muscle mass in patients with tuberous sclerosis complex (TSC).
Materials And Methods: In this retrospective study, patients with TSC who were taking mTOR inhibitors and who underwent at least two abdominal CT or MRI examinations between 2005 and 2017 were included ( = 24; 14 males; mean age, 14.5 years ± 7. Read More