Are Sporadic Eosinophilic Solid and Cystic Renal Cell Carcinomas Characterized by Somatic Tuberous Sclerosis Gene Mutations?
- Megan Parilla,
- Sabah Kadri,
- Sushant A Patil,
- Lauren Ritterhouse,
- Jeremy Segal,
- Kammi J Henriksen,
- Tatjana Antic
Am J Surg Pathol 2018 Apr 17. Epub 2018 Apr 17.
Department of Pathology, University of Chicago, Chicago, IL.
Eosinophilic solid and cystic renal cell carcinomas (ESC RCC) is a rare, unique tumor type not yet included in the World Health Organization classification of renal neoplasia. Separately, RCCs found in patients with tuberous sclerosis complex (TSC) have recently been categorized into 3 morphologic groups: RCC with a tubulopapillary architecture separated by smooth muscle stroma, chromophobe-like, and eosinophilic-microcytic type. The third classification has been identified in ∼11% of TSC-associated RCC and have histology identical to ESC RCCs. Read More