8,153 results match your criteria Tuberculous Meningitis


as a cause of acute CNS infection in an immune-competent girl undergoing repeated VP shunt surgeries.

BMJ Case Rep 2019 Apr 15;12(4). Epub 2019 Apr 15.

Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India.

We present the case of a 14-year-old immune-competent girl with ventriculoperitoneal shunt who was repeatedly hospitalised with meningeal signs despite repeated shunt revision surgeries. Eventually was isolated and the patient improved after specific treatment. is a rapidly growing, non-tuberculous mycobacterium (NTM). Read More

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http://dx.doi.org/10.1136/bcr-2018-226900DOI Listing
April 2019
1 Read

Structural switching electrochemical DNA aptasensor for the rapid diagnosis of tuberculous meningitis.

Int J Nanomedicine 2019 26;14:2103-2113. Epub 2019 Mar 26.

AptaBharat Innovation Pvt. Ltd., Faridabad, India,

Background: Tuberculous meningitis (TBM) is the most devastating manifestation of extra-pulmonary tuberculosis. About 33% of TBM patients die due to very late diagnosis of the disease. Conventional diagnostic methods based on signs and symptoms, cerebrospinal fluid (CSF) smear microscopy or liquid culture suffer from either poor sensitivity or long turnaround time (up to 8 weeks). Read More

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http://dx.doi.org/10.2147/IJN.S189127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440448PMC
March 2019
2 Reads

[Recurrent vomiting and headaches in a 26-year-old male patient].

Internist (Berl) 2019 Apr 12. Epub 2019 Apr 12.

I. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

This article reports the case of a 26-year-old male patient with recurrent emesis and headache due to central nervous system tuberculosis. The thoracic computed tomography showed bilateral disseminated pulmonary micronodular infiltrates and a cavern connecting to the bronchial system. The cranial magnetic resonance imaging showed multiple supratentorial and infratentorial microabscesses with concomitant meningitis. Read More

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http://link.springer.com/10.1007/s00108-019-0597-4
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http://dx.doi.org/10.1007/s00108-019-0597-4DOI Listing
April 2019
2 Reads

Role of Oxidative Stress in Tuberculous Meningitis: a Clinico-Radiological Correlation.

J Mol Neurosci 2019 Apr 11. Epub 2019 Apr 11.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

Central nervous system infection may be associated with oxidative stress and may influence clinical severity and outcome. We report oxidative stress markers in the patients with tuberculous meningitis (TBM) and correlate these with clinico-radiological severity and outcome. Fifty-six patients with TBM diagnosed on the basis of clinical, cerebrospinal fluid (CSF), and magnetic resonance (MRI) were included. Read More

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http://link.springer.com/10.1007/s12031-019-01304-0
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http://dx.doi.org/10.1007/s12031-019-01304-0DOI Listing
April 2019
2 Reads

[Update on the use of steroids in infectious diseases].

Rev Med Suisse 2019 Apr;15(646):792-796

Service des maladies infectieuses, HUG, 1211 Genève 14.

It is well established in daily clinical practice, on the basis of randomized studies, to add corticosteroïds to the antibiotherapy in cases of S. pneumoniae H. influenzae meningitis, tuberculous meningitis and Pneumocystis jiroveci pneumonia in HIV patients. Read More

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April 2019
1 Read

Pneumococcal pericarditis, endocarditis, and pneumococcal and tuberculous co-infection are other cardiovascular complications of pneumococcal pneumonia.

Authors:
Oscar M P Jolobe

J Intern Med 2019 Apr 9. Epub 2019 Apr 9.

Manchester Medical Society, Simon Building, Brunswick Street, Manchester, M13 9PL.

No account of cardiovascular events in patients with pneumococcal community-acquired pneumonia(1) would be complete without mention of cardiovascular complications of pneumococcal pneumonia such as pneumococcal pericarditis(2), and pneumococcal endocarditis(3)(4)(5). Also worthy of mention is the coexistence of pneumococcal pericarditis tuberculous pericarditis in the human immune deficiency virus(HIV) infection era(6), and the co-uccurence of endocarditis of presumably pneumococcal origin, and pneumococcal pneumonia complicated by pneumococcal meningitis in a patient with coexisting pulmonary tuberculosis and tuberculous meningitis, in the era antedating the HIV pandemic. This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/joim.12914DOI Listing
April 2019
1 Read

Unusual cause of progressively impaired cognitive function: complex meningoencephalitis.

BMJ Case Rep 2019 Apr 3;12(4). Epub 2019 Apr 3.

Department of Internal Medicine, Akiota Hospital, Yamagata-gun, Hiroshima, Japan.

complex (MAC) is a rare cause of meningoencephalitis. Non-tuberculous mycobacterium meningoencephalitis including MAC meningoencephalitis is an important cause of rapidly progressive dementia. We present a case of MAC meningoencephalitis in an immunosuppressed woman who had progressively impaired cognitive function. Read More

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22902
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http://dx.doi.org/10.1136/bcr-2018-229022DOI Listing
April 2019
5 Reads

Dynamic prediction of death in patients with tuberculous meningitis using time-updated Glasgow coma score and plasma sodium measurements.

Clin Infect Dis 2019 Apr 4. Epub 2019 Apr 4.

Oxford University Clinical Research Unit, Ho Chi Minh City, Viet Nam.

Background: Pre-treatment predictors of death from tuberculous meningitis (TBM) are well-established, but whether outcome can be predicted more accurately after the start of treatment by updated clinical variables is unknown. Hence, we developed and validated models that dynamically predict mortality using time-updated Glasgow coma score (GCS) and plasma sodium measurements, together with patient baseline characteristics.

Methods: We included 1048 adults from four TBM studies conducted in southern Vietnam from 2004-2016. Read More

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https://academic.oup.com/cid/advance-article/doi/10.1093/cid
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http://dx.doi.org/10.1093/cid/ciz262DOI Listing
April 2019
6 Reads

Xpert MTB/RIF Ultra for the Detection of in Cerebrospinal Fluid.

J Clin Microbiol 2019 Apr 3. Epub 2019 Apr 3.

Department of Medical Microbiology, Makerere University, Kampala, Uganda.

Tuberculous meningitis (TBM) is the most lethal manifestation of tuberculosis and requires rapid diagnosis and initiation of treatment to prevent death and serious neurological disability.…. Read More

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http://dx.doi.org/10.1128/JCM.00249-19DOI Listing
April 2019
4 Reads

A systematic review and meta-analysis of the diagnostic accuracy of nucleic acid amplification tests in cerebrospinal fluid for tuberculous meningitis.

J Clin Microbiol 2019 Apr 3. Epub 2019 Apr 3.

Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, KS, USA.

Diagnosis of tuberculous meningitis (TBM) is difficult and poses a significant challenge to physicians worldwide. Recently, nucleic acid amplification (NAA) tests have shown promise for diagnosis of TBM, although performance has been variable. We undertook a systematic review and meta-analysis to evaluate the diagnostic accuracy of NAA tests in cerebrospinal fluid (CSF) samples against culture as the reference standard or a combined reference standard (CRS) for TBM. Read More

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http://dx.doi.org/10.1128/JCM.01113-18DOI Listing
April 2019
1 Read

Recurrent Paradoxical Tuberculosis with Chest Wall Abscess and Optochiasmatic Tuberculoma.

J Pediatr Neurosci 2018 Oct-Dec;13(4):500-502

Department of Paediatric Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

New-onset clinical or radiological symptoms in a patient with tuberculosis pose diagnostic treatment challenges, which can be due to treatment failure, disease relapse, or paradoxical response. We describe an adolescent case of recurrent paradoxical response complicating tuberculous meningitis. The first paradoxical tuberculosis presented as chest wall abscess, which was complicated by uniocular, gradually progressive, painless loss of vision after 6 months. Read More

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http://dx.doi.org/10.4103/JPN.JPN_90_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413591PMC
April 2019
2 Reads

A Clinical scoring model to predict mortality in HIV/TB co-infected patients at end stage of AIDS in China: An observational cohort study.

Biosci Trends 2019 Mar 29. Epub 2019 Mar 29.

Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University.

We construct and validate a non-invasive clinical scoring model to predict mortality in HIV/TB patients at end stage of AIDS in China. There were 1,007 HIV/TB patients admitted to Beijing Ditan Hospital from August 2009 to January 2018 included in this study, who were randomly assigned to form derivation cohort and validation cohort. A clinical scoring model was developed based on predictors associated with mortality identified with Cox proportional hazard models. Read More

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https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_201
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http://dx.doi.org/10.5582/bst.2018.01309DOI Listing
March 2019
4 Reads

The rapid molecular test Xpert MTB/RIF Ultra: towards improved tuberculosis diagnosis and rifampicin resistance detection.

Clin Microbiol Infect 2019 Mar 27. Epub 2019 Mar 27.

Institute of Microbiology, University of Lausanne, University Hospital of Lausanne, Lausanne, Switzerland.

Background: Tuberculosis diagnosis has dramatically improved since the introduction of the rapid molecular test Xpert MTB/RIF (Xpert) detecting M. tuberculosis and rifampicin resistance directly from clinical specimens, therefore shortening the turnaround time, reducing patient's isolation period and decreasing the time to start anti-TB drugs. The new version, Xpert MTB/RIF Ultra (Ultra), displays a higher sensitivity and an improved rifampicin resistance detection. Read More

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http://dx.doi.org/10.1016/j.cmi.2019.03.021DOI Listing
March 2019
2 Reads

Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis.

Neurol Res 2019 Mar;41(3):199-203

a Department of Neurology , Beijing Ditan Hospital, Capital Medical University , Beijing , China.

Objective To investigate the diagnostic value of electroencephalogram (EEG) complexity in patients with neurosyphilis by comparing the changes of electroencephalogram Lempel-Ziv complexity (EEG-LZC) before and after anti-syphilis treatment. Methods The EEG complexity of neurosyphilis patients diagnosed in our hospital from July in 2015 to June in 2017 was analyzed and compared with other diagnostic results such as serology examination and cerebrospinal fluid examination. Results A total of 27 patients were diagnosed, including 19 males and 8 females, of which 6 were mesenchymal(cerebrospinal membrane and meningeal vascular), 16 were parenchymal(paralytic dementia, spinal cord tuberculosis and optic neuropathy), and 5 were asymptomatic. Read More

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http://dx.doi.org/10.1080/01616412.2018.1520438DOI Listing
March 2019
1 Read

Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review.

Int J Mol Sci 2019 Mar 18;20(6). Epub 2019 Mar 18.

Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town 7925, South Africa.

Tuberculosis (TB) remains the single biggest infectious cause of death globally, claiming almost two million lives and causing disease in over 10 million individuals annually. Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes with various physiological roles implicated as key factors contributing to the spread of TB. They are involved in the breakdown of lung extracellular matrix and the consequent release of bacilli into the airways. Read More

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http://dx.doi.org/10.3390/ijms20061350DOI Listing
March 2019
2 Reads

Gender and time delays in diagnosis of pulmonary tuberculosis: a cross-sectional study from China.

Epidemiol Infect 2019 Jan;147:e94

Yulin Center for Disease Control and Prevention,Shaanxi, 719000,China.

Gender inequality has severe consequences on public health in terms of delay in diagnosis of pulmonary tuberculosis (PTB). In order to explore gender-related differences in diagnosis delay, a cross-sectional study of 10 686 patients diagnosed with PTB in Yulin from 1 January 2009 to 31 December 2014 was conducted. Diagnosis delay was categorised into 'short delay' and 'long delay' by four commonly used cut-off points of 14, 30, 60 and 90 days. Read More

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http://dx.doi.org/10.1017/S0950268819000049DOI Listing
January 2019
4 Reads

Multiple spinal intramedullary PNETs mimicking acute myelitis: a case report.

World Neurosurg 2019 Mar 1. Epub 2019 Mar 1.

Department of Radiology, Shaanxi Provincial People's Hospital. Electronic address:

Background: Primitive neuroectodermal tumors (PNETs) are rare malignant neoplasms in the spinal cord that comprise undifferentiated or poorly differentiated neural crest cells. PNETs imaging findings lack specificity, making diagnosis difficult.

Case Description: A 16-year-old man presented with progressive weakness and numbness of the lower extremities for 1 month, which occurred after a cold. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.02.108DOI Listing
March 2019
1 Read

Monitoring Treatment of Childhood Tuberculosis and the Role of Therapeutic Drug Monitoring.

Indian J Pediatr 2019 Feb 28. Epub 2019 Feb 28.

Department of Pediatrics, Baylor College of Medicine, 1102 Bates Street, Houston, TX, 77030, USA.

Most children tolerate the first-line antibiotics used to treat Mycobacterium tuberculosis (TB) very well. The most common adverse effect is gastrointestinal distress unrelated to hepatotoxicity; the latter is seen in less than 1% of children. Despite the infrequency of hepatotoxicity, the potential long-term impact of hepatic insufficiency dictates that all children receiving antimycobacterial therapy should be evaluated periodically by symptom screening and physical examination. Read More

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http://dx.doi.org/10.1007/s12098-019-02882-yDOI Listing
February 2019
1 Read

A simple microfluidic assay for diagnosing tuberculous meningitis in HIV-uninfected patients.

J Clin Microbiol 2019 Feb 27. Epub 2019 Feb 27.

Departments of Infectious Diseases, Convergence Medicine, Asan Medical Institute of Convergence Science and Technology, and Neurology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

We evaluated the diagnostic performance of a simple and label-free pathogen enrichment method using homobifunctional imidoesters and a microfluidic assay (SLIM) followed by real-time PCR from cerebrospinal fluid (CSF) in HIV-uninfected patients with suspected tuberculous meningitis (TBM). Patients with suspected TBM were prospectively enrolled in a tertiary hospital in an intermediate TB-burden country, during a 30-month period. TBM was classified according to the uniform case definition. Read More

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http://dx.doi.org/10.1128/JCM.01975-18DOI Listing
February 2019
1 Read

Magnetic resonance imaging spectrum of intracranial tubercular lesions: one disease, many faces.

Pol J Radiol 2018 29;83:e524-e535. Epub 2018 Dec 29.

Jackson Memorial Hospital, Miami, USA.

Tuberculosis is a devastating disease and has shown resurgence in recent years with the advent of acquired immunodeficiency syndrome. Central nervous system involvement is the most devastating form of the disease, comprising 10% of all tuberculosis cases. The causative organism, , incites a granulomatous inflammatory response in the brain, the effects of which can be appreciated on magnetic resonance imaging (MRI), which can thus be used for diagnosis of the same. Read More

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http://dx.doi.org/10.5114/pjr.2018.81408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6384409PMC
December 2018

Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India.

Indian J Tuberc 2019 Jan 16;66(1):49-57. Epub 2017 Jun 16.

Department of Respiratory Medicine, King George Medical University, Lucknow, Uttar Pradesh, India.

Objectives: Central nervous system (CNS) is an important site for extrapulmonary tuberculosis. The present study evaluated the spectrum of CNS tuberculosis in a high tuberculosis endemic region.

Methods: The study included 306 cases of CNS tuberculosis. Read More

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http://dx.doi.org/10.1016/j.ijtb.2017.05.011DOI Listing
January 2019
1 Read

Xpert MTB/RIF Ultra improved the diagnosis of paucibacillary tuberculosis: A prospective cohort study.

J Infect 2019 Apr 21;78(4):311-316. Epub 2019 Feb 21.

National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beiguan St #9, Beijing, China. Electronic address:

Objectives: We assessed the diagnostic performance of Xpert MTB/RIF Ultra (Xpert Ultra) in comparison to Xpert MTB/RIF (Xpert) for the detection of paucibacillary tuberculosis (TB).

Methods: Smear-negative sputum, pleural fluid and cerebrospinal fluid (CSF) were collected from TB suspects at Beijing Chest Hospital (Beijing, China) and were examined using smear, Xpert and culture. Xpert Ultra was tested using specimens stored at -80 °C. Read More

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http://dx.doi.org/10.1016/j.jinf.2019.02.010DOI Listing

A Case of Tuberculosis-related Leukocytoclastic Vasculitis Presenting With Peripheral Neuropathy.

Cureus 2018 Dec 7;10(12):e3703. Epub 2018 Dec 7.

Neurology, Keck School of Medicine of the University of Southern California, Los Angeles, USA.

Tuberculous granulomatous vasculitis is commonly associated with meningitis and retinitis. We describe a 39-year-old male, with a history of pulmonary tuberculosis (TB) who presented with progressive weakness, pain, tingling and numbness in the bilateral lower extremities. Significant atrophy and weakness of the lower extremities were evident along with absent reflexes. Read More

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http://dx.doi.org/10.7759/cureus.3703DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6372249PMC
December 2018
1 Read

Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):71-77

Senior Clinical Scientist, Department of Clinical Research, Dr. Agarwal's Healthcare Limited, Tirunelveli, Tamil Nadu, India.

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus.

Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS).

Materials And Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337963PMC
February 2019
1 Read

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018
1 Read

An Overview on Epidemiology of Tuberculosis.

Mymensingh Med J 2019 Jan;28(1):259-266

Dr Mohammad Kamruzzaman Khan, Lecturer, Department of Community Medicine, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail: kamruz

Tuberculosis (TB) is a progressive granulomatous infectious disease caused by the gram positive, acid fast bacilli classified under the genus Mycobacterium. Tuberculosis in human is mostly by Mycobacterium tuberculosis and primarily affects lungs causing pulmonary tuberculosis. It can also affect intestine, meninges, bones, joints, lymph nodes, skin and other tissues of the body causing extra-pulmonary tuberculosis. Read More

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January 2019
3 Reads

Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.

J Pediatric Infect Dis Soc 2019 Feb 12. Epub 2019 Feb 12.

Division of Neurosurgery, Department of Surgery.

We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis. Read More

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http://dx.doi.org/10.1093/jpids/piy141DOI Listing
February 2019
1 Read

Multidrug-resistant tuberculous meningitis in a returned traveller.

J Paediatr Child Health 2019 Feb 11. Epub 2019 Feb 11.

Department of Infectious Diseases and Microbiology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

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http://doi.wiley.com/10.1111/jpc.14387
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http://dx.doi.org/10.1111/jpc.14387DOI Listing
February 2019
10 Reads

Integrating exosomal microRNAs and electronic health data improved tuberculosis diagnosis.

EBioMedicine 2019 Feb 8;40:564-573. Epub 2019 Feb 8.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Background Tuberculosis (TB) is difficult to diagnose under complex clinical conditions as electronic health records (EHRs) are often inadequate in making an affirmative diagnosis. As exosomal miRNAs emerged as promising biomarkers, we investigated the potential of using exosomal miRNAs and EHRs in TB diagnosis.

Methods: A total of 370 individuals, including pulmonary tuberculosis (PTB), tuberculous meningitis (TBM), non-TB disease controls and healthy state controls, were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193002
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http://dx.doi.org/10.1016/j.ebiom.2019.01.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413343PMC
February 2019
11 Reads

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Front Immunol 2019 25;10:58. Epub 2019 Jan 25.

Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare condition of primary immunodeficiency disorder. Interleukin-12 receptor β1 (IL12RB1) deficiency, is the most common genetic etiology of MSMD, which is characterized by the selective predisposition to clinical disease caused by weakly-virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines, and environmental non-tuberculous mycobacteria (NTM). To the best of our knowledge, this is the first case of deficiency to be reported from Iraq. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355664PMC
January 2019
4 Reads

Dural masses: meningiomas and their mimics.

Insights Imaging 2019 Feb 6;10(1):11. Epub 2019 Feb 6.

Department of Neuroradiology, St Bartholomew's and the Royal London Hospitals, Whitechapel, London, E1 1BB, UK.

Meningiomas are the most common dural tumour. They are regularly being seen as an incidental finding on brain imaging and treated conservatively. However, there are many other dural masses which mimic their appearances, including primary neoplastic processes, metastases, granulomatous diseases and infection. Read More

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http://dx.doi.org/10.1186/s13244-019-0697-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365311PMC
February 2019
13 Reads

Ophthalmological manifestation in patients of tuberculous meningitis.

QJM 2019 Feb 5. Epub 2019 Feb 5.

Professor, Department of Ophthalmology, King George's Medical University, Lucknow, India.

Background: Vision impairment, blindness in particular is a devastating complication in patients with Tubercular meningitis. However information regarding ophthalmological manifestation and its impact on vision is sparse in the literature. This study evaluated the spectrum of ophthalmological manifestations in tuberculous meningitis, including retinal nerve fiber layer thickness assessment by optic coherence tomography and its correlation with visual and clinical outcome. Read More

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http://dx.doi.org/10.1093/qjmed/hcz037DOI Listing
February 2019
4 Reads

Seizures in Children with HIV infection in South Africa: A retrospective case control study.

Seizure 2019 Feb 28;65:159-165. Epub 2019 Jan 28.

University of Cape Town Neuroscience Institute, Faculty of Health Sciences, Anzio Road, Observatory, Cape Town 7295 South Africa; Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Klipfontein Road, Rondebosch, Cape Town, 7700 South Africa. Electronic address:

Purpose: Data relating to the role that Human immunodeficiency virus (HIV) contributes towards seizures in HIV-infected children is limited. The management of seizures in this group is complex due to potential interactions between antiseizure medication and antiretroviral therapies. This study explores the seizure semiology and course of a population of affected children based on questions raised from a previous epidemiological study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183041
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http://dx.doi.org/10.1016/j.seizure.2019.01.023DOI Listing
February 2019
13 Reads

Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study.

Sci Rep 2019 Jan 29;9(1):884. Epub 2019 Jan 29.

Radboud University Medical Center, Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Nijmegen, The Netherlands.

Immunopathology contributes to high mortality in tuberculous meningitis (TBM) but little is known about the blood and cerebrospinal fluid (CSF) immune response. We prospectively characterised the immune response of 160 TBM suspects in an Indonesian cohort, including 67 HIV-negative probable or definite TBM cases. TBM patients presented with severe disease and 38% died in 6 months. Read More

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http://dx.doi.org/10.1038/s41598-018-36696-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351535PMC
January 2019
3 Reads

Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection.

Wellcome Open Res 2018 15;3:111. Epub 2019 Jan 15.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.

In 2016, 10.4 million cases of tuberculosis (TB) were reported globally. Malaria also continues to be a global public health threat. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.14726.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343228PMC
January 2019
6 Reads

Duration of anti-tuberculous therapy in children with persistent tuberculomas.

SAGE Open Med Case Rep 2019 9;7:2050313X18823092. Epub 2019 Jan 9.

Pediatric TB Clinic, Department of Pediatric Infectious Diseases, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

The usual treatment duration of tuberculomas recommended is 1 year. While anti-tuberculous therapy is of absolute necessity for the treatment of central nervous system tuberculosis, no clear guidelines exist regarding the duration of therapy in case of persistent tuberculomas. We present a series of six cases of children with central nervous system tuberculosis who received anti-tuberculous therapy for a period varying between 23 and 32 months depending on the resolution of lesion seen in neuroradiological scans of the patients. Read More

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http://dx.doi.org/10.1177/2050313X18823092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329029PMC
January 2019

Grading tuberculous meningitis.

Authors:
Peter Baxter

Clin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Paediatric Neurologist Childrens Hospital Sheffield UK.

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http://dx.doi.org/10.1093/cid/ciz024DOI Listing
January 2019
1 Read

Reply to Baxter.

Clin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1093/cid/ciz026DOI Listing
January 2019
2 Reads

The pathogenesis of tuberculous meningitis.

J Leukoc Biol 2019 Feb 15;105(2):267-280. Epub 2019 Jan 15.

The Francis Crick Institute, Midland Road, London, United Kingdom.

Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M. Read More

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http://doi.wiley.com/10.1002/JLB.MR0318-102R
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http://dx.doi.org/10.1002/JLB.MR0318-102RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355360PMC
February 2019
14 Reads

A Child with Tuberculous Meningitis Complicated by Cortical Venous and Cerebral Sino-Venous Thrombosis.

Indian J Pediatr 2019 Apr 9;86(4):371-378. Epub 2019 Jan 9.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Stroke is common in tuberculous meningitis. Stroke commonly affects the tubercular zone, comprising the anterior part of the thalamus, caudate and the internal capsule (anterior limb and genu). Stroke, in tuberculous meningitis is predominantly arterial ischemic stroke, and is due to infiltrative, proliferative or necrotizing arteritis. Read More

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http://link.springer.com/10.1007/s12098-018-2830-x
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http://dx.doi.org/10.1007/s12098-018-2830-xDOI Listing
April 2019
13 Reads
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Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer.

Int J Tuberc Lung Dis 2019 Feb 8;23(2):136-139. Epub 2019 Jan 8.

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China.

Objective: To analyse the clinical characteristics of miliary tuberculosis (TB) in pregnant women after in vitro fertilisation and embryo transfer (IVF-ET).

Methods: Six pregnant women with miliary TB after IVF-ET between October 2010 and July 2015 were retrospectively analysed.

Results: The patients were aged between 29 and 39 years. Read More

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http://dx.doi.org/10.5588/ijtld.18.0223DOI Listing
February 2019
4 Reads

Mortality in hospitalized patients with tuberculous meningitis.

BMC Infect Dis 2019 Jan 5;19(1). Epub 2019 Jan 5.

Departments of Neurology, Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA, USA.

Background: To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality.

Methods: Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generalized linear regression to identify factors predictive of in-hospital mortality.

Results: Of 263 patients, the median age was 35 years, 72. Read More

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http://dx.doi.org/10.1186/s12879-018-3633-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321688PMC
January 2019
3 Reads

Ultrastructural analysis of cell wall of drug resistant and sensitive Mycobacterium tuberculosis isolated from cerebrospinal fluid by transmission electron microscope.

Microsc Res Tech 2019 Feb 21;82(2):122-127. Epub 2018 Dec 21.

Department of Neuromicrobiology, National Institute of Mental Health and Neuroscience, Bengaluru, Karnataka, India.

Drug-resistant tuberculosis is being increasingly recognized and is one among the leading cause of death worldwide. Remarkable impermeability of cell wall to antituberculous drugs protects the mycobacteria from drug action. The present study analyzed the cell wall thickness among first-line drug resistant and sensitive Mycobacterium tuberculosis (Mtb) isolated from cerebrospinal fluid by transmission electron microscopy (TEM). Read More

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http://dx.doi.org/10.1002/jemt.23144DOI Listing
February 2019

[Etiology and clinical features of epilepsia partialis continua: an analysis of six cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1008-1014

Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the etiology and clinical features of epilepsia partialis continua (EPC) in children.

Methods: A retrospective analysis was performed for the clinical features, diagnosis and treatment of six children with EPC, and the clinical and laboratory features and prognosis were compared between the children with different etiologies.

Results: There were five girls and one boy, with an onset age ranging from one year and seven months to nine years. Read More

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December 2018
14 Reads

Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

Neurol Clin Pract 2018 Oct;8(5):379-388

Departments of Neurology (DI, RE, KM, Sucipto, DO, DNL), Microbiology (DCL, A. Karuniawati), Radiology (REY, RM), Internal Medicine (EY, THK), Clinical Pathology (IST, DW), and Parasitology (RW, RA, A. Kurniawan), Cipto Mangunkusumo Hospital-Faculty of Medicine Universitas Indonesia; Eijkman Institute for Molecular Biology (UAJ, DS, KSAM); Eijkman-Oxford Clinical Research Unit (UAJ), Jakarta, Indonesia; Department of Internal Medicine and Radboud Center for Infectious Diseases (AvL, RvC), Radboud University Medical Center, Nijmegen, the Netherlands; TB/HIV Research Center (BA, SD, LC, ARG), Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; and Centre for Tropical Medicine and Global Health (RvC), Nuffield Department of Medicine, University of Oxford, UK.

Background: Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

Methods: From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276332PMC
October 2018
12 Reads

Tuberculous Meningitis, Vasculitis, and Pericarditis presented by deep coma.

Pak J Med Sci 2018 Nov-Dec;34(6):1576-1578

Sultan Abdulwadoud Alshoabi, MD. Department of Diagnostic Radiologic Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunwwarah, Saudi Arabia. E-mail:

A 32 years old male patient presented to the emergency room with complete loss of consciousness since three hours. This was after two weeks of night fever, sweating and considerable loss of weight with self-treatment by antipyretic drugs. In the last two days, the patient develops confusion and altered behavior. Read More

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http://pjms.com.pk/index.php/pjms/article/view/16350
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http://dx.doi.org/10.12669/pjms.346.16350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290220PMC
December 2018
22 Reads

Global shortages of BCG vaccine and tuberculous meningitis in children.

Lancet Glob Health 2019 01;7(1):e28-e29

Tygerberg Hospital, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1016/S2214-109X(18)30474-1DOI Listing
January 2019

Scrofuloderma with disseminated tuberculosis in an Ethiopian child: a case report.

Authors:
Henok Tadele

J Med Case Rep 2018 Dec 17;12(1):371. Epub 2018 Dec 17.

Department of Pediatrics and Child Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Cutaneous tuberculosis represents only 1-2% of extrapulmonary forms of tuberculosis. Scrofuloderma is an endogenous form of cutaneous tuberculosis and can present as isolated or coexist with pulmonary and disseminated forms of tuberculosis. Pathologically confirmed scrofuloderma coexisting with disseminated tuberculosis with a good treatment response is presented and discussed. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1927-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296023PMC
December 2018
9 Reads

Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study.

J Neurol Sci 2019 Feb 7;397:11-15. Epub 2018 Dec 7.

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Objective: Computed tomography (CT) of the thorax is the imaging modality of choice to detect or demonstrate lesions suggestive of active pulmonary tuberculosis. We aimed to evaluate the imaging abnormalities detected on CT of the thorax in patients with tuberculous meningitis (TBM).

Methods: In this prospective study, we enrolled consecutive newly-diagnosed patients with TBM. Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.010DOI Listing
February 2019
1 Read

Outcome of Ventriculoperitoneal Shunt Surgery in Human Immunodeficiency Virus-Positive Patients on Combination Antiretroviral Therapy with Tuberculosis Meningitis and Hydrocephalus.

World Neurosurg 2019 Mar 7;123:e574-e580. Epub 2018 Dec 7.

Bupa Cromwell Hospital, West London, London, United Kingdom.

Background: In 2000, we advised against insertion of a ventriculoperitoneal shunt (VPS) in human immunodeficiency virus (HIV)-positive patients with tuberculous meningitis (TBM) complicated by hydrocephalus. However, this was in the era when combination antiretroviral therapy (ART) was not freely available in South Africa. In this subsequent preliminary report, we describe the outcome of ventriculoperitoneal shunting in patients with TBM and hydrocephalus who are HIV positive and receiving ART. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.221DOI Listing
March 2019
4 Reads