8,123 results match your criteria Tuberculous Meningitis


Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management.

J Neurosci Rural Pract 2019 Jan-Mar;10(1):71-77

Senior Clinical Scientist, Department of Clinical Research, Dr. Agarwal's Healthcare Limited, Tirunelveli, Tamil Nadu, India.

Introduction: Tuberculosis (TB) is a major global problem and poses a threat which is of considerable magnitude, with an estimated one-third of the population infected with TB bacillus.

Aim: The aim of this study is to study the treatment outcomes in patients with various forms of neurological TB treated with the standardized Revised National TB Control Program (RNTCP), directly observed treatment short-course (DOTS).

Materials And Methods: Patients diagnosed to have TBM, tuberculoma with or without spinal arachnoiditis (central nervous system tuberculosis-TB [CNS-TB]) were categorized as per the RNTCP guidelines and received DOTS Category I or Category II thrice-weekly intermittent treatment as deemed appropriate. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_163_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337963PMC
February 2019

[Central Neurological Diagnosis in Patients Infected with HIV in the Infectious Diseases Unit of University Hospital of Casablanca, Morocco].

Bull Soc Pathol Exot 2018 ;111(1):24-30

Service des maladies infectieuses, CHU de Ibn Rochd, Casablanca, Maroc.

The aim of this work is to study the epidemiology of central neurological system (CNS) diagnosed in the population of people living with HIV in the department of infectious diseases in UHC Ibn Rochd of Casablanca from January 2005 to May 2015. The demographic and clinical profile along with the outcome of these patients were studied. The data were collected from Nadis software. Read More

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http://dx.doi.org/10.3166/bspe-2018-0004DOI Listing
January 2018

An Overview on Epidemiology of Tuberculosis.

Mymensingh Med J 2019 Jan;28(1):259-266

Dr Mohammad Kamruzzaman Khan, Lecturer, Department of Community Medicine, Mymensingh Medical College (MMC), Mymensingh, Bangladesh; E-mail: kamruz

Tuberculosis (TB) is a progressive granulomatous infectious disease caused by the gram positive, acid fast bacilli classified under the genus Mycobacterium. Tuberculosis in human is mostly by Mycobacterium tuberculosis and primarily affects lungs causing pulmonary tuberculosis. It can also affect intestine, meninges, bones, joints, lymph nodes, skin and other tissues of the body causing extra-pulmonary tuberculosis. Read More

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January 2019
1 Read

Elevated Matrix Metalloproteinase Concentrations Offer Novel Insight Into Their Role in Pediatric Tuberculous Meningitis.

J Pediatric Infect Dis Soc 2019 Feb 12. Epub 2019 Feb 12.

Division of Neurosurgery, Department of Surgery.

We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis. Read More

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http://dx.doi.org/10.1093/jpids/piy141DOI Listing
February 2019
1 Read

Multidrug-resistant tuberculous meningitis in a returned traveller.

J Paediatr Child Health 2019 Feb 11. Epub 2019 Feb 11.

Department of Infectious Diseases and Microbiology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

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http://doi.wiley.com/10.1111/jpc.14387
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http://dx.doi.org/10.1111/jpc.14387DOI Listing
February 2019
2 Reads

Integrating exosomal microRNAs and electronic health data improved tuberculosis diagnosis.

EBioMedicine 2019 Feb 7. Epub 2019 Feb 7.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address:

Background Tuberculosis (TB) is difficult to diagnose under complex clinical conditions as electronic health records (EHRs) are often inadequate in making an affirmative diagnosis. As exosomal miRNAs emerged as promising biomarkers, we investigated the potential of using exosomal miRNAs and EHRs in TB diagnosis.

Methods: A total of 370 individuals, including pulmonary tuberculosis (PTB), tuberculous meningitis (TBM), non-TB disease controls and healthy state controls, were enrolled. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23523964193002
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http://dx.doi.org/10.1016/j.ebiom.2019.01.023DOI Listing
February 2019
2 Reads

A Syrian Refugee in Iraq Diagnosed as a Case of IL12RB1 Deficiency in Japan Using Dried Blood Spots.

Front Immunol 2019 25;10:58. Epub 2019 Jan 25.

Center for Advanced Medicine and Clinical Research, Nagoya University Hospital, Nagoya, Japan.

Mendelian susceptibility to mycobacterial diseases (MSMD) is a rare condition of primary immunodeficiency disorder. Interleukin-12 receptor β1 (IL12RB1) deficiency, is the most common genetic etiology of MSMD, which is characterized by the selective predisposition to clinical disease caused by weakly-virulent mycobacteria, such as Bacillus Calmette-Guérin (BCG) vaccines, and environmental non-tuberculous mycobacteria (NTM). To the best of our knowledge, this is the first case of deficiency to be reported from Iraq. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355664PMC
January 2019
1 Read

Dural masses: meningiomas and their mimics.

Insights Imaging 2019 Feb 6;10(1):11. Epub 2019 Feb 6.

Department of Neuroradiology, St Bartholomew's and the Royal London Hospitals, Whitechapel, London, E1 1BB, UK.

Meningiomas are the most common dural tumour. They are regularly being seen as an incidental finding on brain imaging and treated conservatively. However, there are many other dural masses which mimic their appearances, including primary neoplastic processes, metastases, granulomatous diseases and infection. Read More

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http://dx.doi.org/10.1186/s13244-019-0697-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365311PMC
February 2019
9 Reads

Ophthalmological manifestation in patients of tuberculous meningitis.

QJM 2019 Feb 5. Epub 2019 Feb 5.

Professor, Department of Ophthalmology, King George's Medical University, Lucknow, India.

Background: Vision impairment, blindness in particular is a devastating complication in patients with Tubercular meningitis. However information regarding ophthalmological manifestation and its impact on vision is sparse in the literature. This study evaluated the spectrum of ophthalmological manifestations in tuberculous meningitis, including retinal nerve fiber layer thickness assessment by optic coherence tomography and its correlation with visual and clinical outcome. Read More

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http://dx.doi.org/10.1093/qjmed/hcz037DOI Listing
February 2019
2 Reads

Seizures in Children with HIV infection in South Africa: A retrospective case control study.

Seizure 2019 Feb 28;65:159-165. Epub 2019 Jan 28.

University of Cape Town Neuroscience Institute, Faculty of Health Sciences, Anzio Road, Observatory, Cape Town 7295 South Africa; Division of Developmental Paediatrics, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Klipfontein Road, Rondebosch, Cape Town, 7700 South Africa. Electronic address:

Purpose: Data relating to the role that Human immunodeficiency virus (HIV) contributes towards seizures in HIV-infected children is limited. The management of seizures in this group is complex due to potential interactions between antiseizure medication and antiretroviral therapies. This study explores the seizure semiology and course of a population of affected children based on questions raised from a previous epidemiological study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10591311183041
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http://dx.doi.org/10.1016/j.seizure.2019.01.023DOI Listing
February 2019
4 Reads

Immune cell characteristics and cytokine responses in adult HIV-negative tuberculous meningitis: an observational cohort study.

Sci Rep 2019 Jan 29;9(1):884. Epub 2019 Jan 29.

Radboud University Medical Center, Department of Internal Medicine and Radboud Center of Infectious Diseases (RCI), Nijmegen, The Netherlands.

Immunopathology contributes to high mortality in tuberculous meningitis (TBM) but little is known about the blood and cerebrospinal fluid (CSF) immune response. We prospectively characterised the immune response of 160 TBM suspects in an Indonesian cohort, including 67 HIV-negative probable or definite TBM cases. TBM patients presented with severe disease and 38% died in 6 months. Read More

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http://dx.doi.org/10.1038/s41598-018-36696-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351535PMC
January 2019
1 Read

Case Report: Three's a crowd: a case report examining the diagnostic and pharmacokinetic challenges in HIV-tuberculous meningitis-malaria co-infection.

Wellcome Open Res 2018 15;3:111. Epub 2019 Jan 15.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, USA.

In 2016, 10.4 million cases of tuberculosis (TB) were reported globally. Malaria also continues to be a global public health threat. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.14726.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343228PMC
January 2019
2 Reads

Duration of anti-tuberculous therapy in children with persistent tuberculomas.

SAGE Open Med Case Rep 2019 9;7:2050313X18823092. Epub 2019 Jan 9.

Pediatric TB Clinic, Department of Pediatric Infectious Diseases, Bai Jerbai Wadia Hospital for Children, Mumbai, India.

The usual treatment duration of tuberculomas recommended is 1 year. While anti-tuberculous therapy is of absolute necessity for the treatment of central nervous system tuberculosis, no clear guidelines exist regarding the duration of therapy in case of persistent tuberculomas. We present a series of six cases of children with central nervous system tuberculosis who received anti-tuberculous therapy for a period varying between 23 and 32 months depending on the resolution of lesion seen in neuroradiological scans of the patients. Read More

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http://dx.doi.org/10.1177/2050313X18823092DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6329029PMC
January 2019

Grading tuberculous meningitis.

Authors:
Peter Baxter

Clin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Paediatric Neurologist Childrens Hospital Sheffield UK.

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http://dx.doi.org/10.1093/cid/ciz024DOI Listing
January 2019
1 Read

Reply to Baxter.

Clin Infect Dis 2019 Jan 14. Epub 2019 Jan 14.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

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http://dx.doi.org/10.1093/cid/ciz026DOI Listing
January 2019
1 Read

The pathogenesis of tuberculous meningitis.

J Leukoc Biol 2019 Feb 15;105(2):267-280. Epub 2019 Jan 15.

The Francis Crick Institute, Midland Road, London, United Kingdom.

Tuberculosis (TB) remains a leading cause of death globally. Dissemination of TB to the brain results in the most severe form of extrapulmonary TB, tuberculous meningitis (TBM), which represents a medical emergency associated with high rates of mortality and disability. Via various mechanisms the Mycobacterium tuberculosis (M. Read More

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http://doi.wiley.com/10.1002/JLB.MR0318-102R
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http://dx.doi.org/10.1002/JLB.MR0318-102RDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355360PMC
February 2019
6 Reads

A Child with Tuberculous Meningitis Complicated by Cortical Venous and Cerebral Sino-Venous Thrombosis.

Indian J Pediatr 2019 Jan 9. Epub 2019 Jan 9.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, 160012, India.

Stroke is common in tuberculous meningitis. Stroke commonly affects the tubercular zone, comprising the anterior part of the thalamus, caudate and the internal capsule (anterior limb and genu). Stroke, in tuberculous meningitis is predominantly arterial ischemic stroke, and is due to infiltrative, proliferative or necrotizing arteritis. Read More

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http://link.springer.com/10.1007/s12098-018-2830-x
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http://dx.doi.org/10.1007/s12098-018-2830-xDOI Listing
January 2019
7 Reads
0.919 Impact Factor

Characteristics of miliary tuberculosis in pregnant women after in vitro fertilisation and embryo transfer.

Int J Tuberc Lung Dis 2019 Jan 8. Epub 2019 Jan 8.

Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang City, Liaoning Province, China.

OBJECTIVE:

To analyse the clinical characteristics of miliary tuberculosis (TB) in pregnant women after in vitro fertilisation and embryo transfer (IVF-ET).

METHODS:

Six pregnant women with miliary TB after IVF-ET between October 2010 and July 2015 were retrospectively analysed.

RESULTS:

The patients were aged between 29 and 39 years. Read More

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http://dx.doi.org/10.5588/ijtld.18.0223DOI Listing
January 2019
2 Reads

Mortality in hospitalized patients with tuberculous meningitis.

BMC Infect Dis 2019 Jan 5;19(1). Epub 2019 Jan 5.

Departments of Neurology, Global Health, Medicine and Epidemiology, University of Washington, Seattle, WA, USA.

Background: To evaluate the mortality in hospitalized patients with tuberculous meningitis and describe factors associated with an increased risk of mortality.

Methods: Retrospective study of hospitalized patients with tuberculous meningitis between 2006 and 2015 in Peru performing a generalized linear regression to identify factors predictive of in-hospital mortality.

Results: Of 263 patients, the median age was 35 years, 72. Read More

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http://dx.doi.org/10.1186/s12879-018-3633-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321688PMC
January 2019
1 Read

[Etiology and clinical features of epilepsia partialis continua: an analysis of six cases].

Zhongguo Dang Dai Er Ke Za Zhi 2018 Dec;20(12):1008-1014

Department of Emergency, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To investigate the etiology and clinical features of epilepsia partialis continua (EPC) in children.

Methods: A retrospective analysis was performed for the clinical features, diagnosis and treatment of six children with EPC, and the clinical and laboratory features and prognosis were compared between the children with different etiologies.

Results: There were five girls and one boy, with an onset age ranging from one year and seven months to nine years. Read More

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December 2018
6 Reads

Presentation, etiology, and outcome of brain infections in an Indonesian hospital: A cohort study.

Neurol Clin Pract 2018 Oct;8(5):379-388

Departments of Neurology (DI, RE, KM, Sucipto, DO, DNL), Microbiology (DCL, A. Karuniawati), Radiology (REY, RM), Internal Medicine (EY, THK), Clinical Pathology (IST, DW), and Parasitology (RW, RA, A. Kurniawan), Cipto Mangunkusumo Hospital-Faculty of Medicine Universitas Indonesia; Eijkman Institute for Molecular Biology (UAJ, DS, KSAM); Eijkman-Oxford Clinical Research Unit (UAJ), Jakarta, Indonesia; Department of Internal Medicine and Radboud Center for Infectious Diseases (AvL, RvC), Radboud University Medical Center, Nijmegen, the Netherlands; TB/HIV Research Center (BA, SD, LC, ARG), Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; and Centre for Tropical Medicine and Global Health (RvC), Nuffield Department of Medicine, University of Oxford, UK.

Background: Little detailed knowledge is available regarding the etiology and outcome of CNS infection, particularly in HIV-infected individuals, in low-resource settings.

Methods: From January 2015 to April 2016, we prospectively included all adults with suspected CNS infection in a referral hospital in Jakarta, Indonesia. Systematic screening included HIV testing, CSF examination, and neuroimaging. Read More

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http://dx.doi.org/10.1212/CPJ.0000000000000517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276332PMC
October 2018
4 Reads

Tuberculous Meningitis, Vasculitis, and Pericarditis presented by deep coma.

Pak J Med Sci 2018 Nov-Dec;34(6):1576-1578

Sultan Abdulwadoud Alshoabi, MD. Department of Diagnostic Radiologic Technology, College of Applied Medical Sciences, Taibah University, Almadinah Almunwwarah, Saudi Arabia. E-mail:

A 32 years old male patient presented to the emergency room with complete loss of consciousness since three hours. This was after two weeks of night fever, sweating and considerable loss of weight with self-treatment by antipyretic drugs. In the last two days, the patient develops confusion and altered behavior. Read More

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http://pjms.com.pk/index.php/pjms/article/view/16350
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http://dx.doi.org/10.12669/pjms.346.16350DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6290220PMC
December 2018
12 Reads

Global shortages of BCG vaccine and tuberculous meningitis in children.

Lancet Glob Health 2019 Jan;7(1):e28-e29

Tygerberg Hospital, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

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http://dx.doi.org/10.1016/S2214-109X(18)30474-1DOI Listing
January 2019

Scrofuloderma with disseminated tuberculosis in an Ethiopian child: a case report.

Authors:
Henok Tadele

J Med Case Rep 2018 Dec 17;12(1):371. Epub 2018 Dec 17.

Department of Pediatrics and Child Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Cutaneous tuberculosis represents only 1-2% of extrapulmonary forms of tuberculosis. Scrofuloderma is an endogenous form of cutaneous tuberculosis and can present as isolated or coexist with pulmonary and disseminated forms of tuberculosis. Pathologically confirmed scrofuloderma coexisting with disseminated tuberculosis with a good treatment response is presented and discussed. Read More

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https://jmedicalcasereports.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/s13256-018-1927-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296023PMC
December 2018
6 Reads

Computed tomography thorax abnormalities in immunocompetent patients with tuberculous meningitis: An observational study.

J Neurol Sci 2019 Feb 7;397:11-15. Epub 2018 Dec 7.

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, India.

Objective: Computed tomography (CT) of the thorax is the imaging modality of choice to detect or demonstrate lesions suggestive of active pulmonary tuberculosis. We aimed to evaluate the imaging abnormalities detected on CT of the thorax in patients with tuberculous meningitis (TBM).

Methods: In this prospective study, we enrolled consecutive newly-diagnosed patients with TBM. Read More

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http://dx.doi.org/10.1016/j.jns.2018.12.010DOI Listing
February 2019
1 Read

Outcome of Ventriculoperitoneal Shunt Surgery in Human Immunodeficiency Virus-Positive Patients on Combination Antiretroviral Therapy with Tuberculosis Meningitis and Hydrocephalus.

World Neurosurg 2018 Dec 7. Epub 2018 Dec 7.

Bupa Cromwell Hospital, West London, London, United Kingdom.

Background: In 2000, we advised against insertion of a ventriculoperitoneal shunt (VPS) in human immunodeficiency virus (HIV)-positive patients with tuberculous meningitis (TBM) complicated by hydrocephalus. However, this was in the era when combination antiretroviral therapy (ART) was not freely available in South Africa. In this subsequent preliminary report, we describe the outcome of ventriculoperitoneal shunting in patients with TBM and hydrocephalus who are HIV positive and receiving ART. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.11.221DOI Listing
December 2018
1 Read

Paradoxical reaction in HIV-negative tuberculous meningitis patients with spinal involvement.

Int J Infect Dis 2019 Feb 4;79:104-108. Epub 2018 Dec 4.

Department of Neurology, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address:

Objective: The aim of this study was to investigate the occurrence of paradoxical reaction (PR) in HIV-negative tuberculous meningitis (TBM) patients with spinal involvement, as well as its possible risk factors.

Methods: Fifty TBM patients with spinal involvement were studied retrospectively and divided into a PR group and a non-PR group according to the presence of PR. Their demographic, clinical, radiological, and laboratory data, and status at follow-up were collected and compared. Read More

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http://dx.doi.org/10.1016/j.ijid.2018.11.366DOI Listing
February 2019
11 Reads
2.330 Impact Factor

Corticosteroid-dependent tuberculous meningitis: A case report.

J Neurol Sci 2019 Jan 17;396:232-234. Epub 2018 Nov 17.

Center for Pulmonary Diseases, National Hospital Organization Tokyo National Hospital, Japan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0022510X183047
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http://dx.doi.org/10.1016/j.jns.2018.11.021DOI Listing
January 2019
3 Reads

Identification of risk factors and diagnostic methodology in serositis by M. tuberculosis

Rev Med Inst Mex Seguro Soc 2018 11 30;56(4):364-370. Epub 2018 Nov 30.

Secretaría de Salud, Hospital General de México “Dr. Eduardo Liceaga”, Unidad de Neumología y Cirugía de Tórax. Ciudad de México, México

Background: Tuberculosis is a public health problem, extrapulmonary presentations have increased, it is difficult to diagnose because of the low bacillary load.

Objective: To identify risk factors and to evaluate the efficiency of diagnostic methods in pleural, meningeal, peritoneal and pericardial tuberculosis.

Methods: Prospective study of cases and controls. Read More

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November 2018
3 Reads

Noninvasive C-rifampin positron emission tomography reveals drug biodistribution in tuberculous meningitis.

Sci Transl Med 2018 Dec;10(470)

Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Tuberculous meningitis (TBM) is a devastating form of tuberculosis (TB), and key TB antimicrobials, including rifampin, have restricted brain penetration. A lack of reliable data on intralesional drug biodistribution in infected tissues has limited pharmacokinetic (PK) modeling efforts to optimize TBM treatments. Current methods to measure intralesional drug distribution rely on tissue resection, which is difficult in humans and generally limited to a single time point even in animals. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau0965DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6360528PMC
December 2018
3 Reads

Role of aspirin as an adjuvant therapy in tuberculous meningitis in adults: The time has come for a phase III randomized controlled trial.

Authors:
Ravi Yadav

Neurol India 2018 Nov-Dec;66(6):1678-1679

Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, Karnataka, India.

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http://dx.doi.org/10.4103/0028-3886.246225DOI Listing
December 2018
1 Read

Does adjunctive corticosteroid and aspirin therapy improve the outcome of tuberculous meningitis?

Neurol India 2018 Nov-Dec;66(6):1672-1677

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Stroke is common in tuberculous meningitis (TBM), and aspirin has been shown to reduce mortality. A combination of aspirin and corticosteroid may be more useful in this condition.

Aim: To evaluate the effect of aspirin and corticosteroid adjunctive therapy alone or in combination in determining the outcome of TBM. Read More

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http://dx.doi.org/10.4103/0028-3886.246278DOI Listing
December 2018
2 Reads

Tuberculous meningitis: Challenges in diagnosis and management: Lessons learnt from Prof. Dastur's article published in 1970.

Neurol India 2018 Nov-Dec;66(6):1550-1571

Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

It has been approximately five decades since Dastur et al., published their seminal work on pathology of tuberculous meningitis (TBM). Though most of their findings find relevance in today's era, there is an important difference; these findings can now be replicated during life using modern day technology. Read More

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http://dx.doi.org/10.4103/0028-3886.246224DOI Listing
December 2018
1 Read

Diabetes insipidus secondary to tuberculous meningoencephalitis with hypothalamic involvement extending to the hypophysis: a case report.

Rev Soc Bras Med Trop 2018 Nov-Dec;51(6):865-867

Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, AM, Brasil.

The involvement of Mycobacterium tuberculosis in the central nervous system (CNS) is an uncommon and devastating manifestation of tuberculosis. We report a case of disseminated tuberculosis presenting as meningoencephalitis, hypothalamic involvement with extension to the hypophysis, and secondary insipidus diabetes diagnosed at autopsy. Read More

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http://dx.doi.org/10.1590/0037-8682-0455-2017DOI Listing
February 2019
3 Reads

Ischemic stroke and infectious diseases in low-income and middle-income countries.

Curr Opin Neurol 2019 Feb;32(1):43-48

Serviço de Neurologia, Hospital das Clínicas da Universidade Federal de Minas Gerais/EBSERH.

Purpose Of Review: To address the important relationships between stroke and infection, focusing on the most frequent infections found in low-income and middle-income countries.

Recent Findings: Stroke is one of the leading causes of mortality and disability worldwide, with a great proportion of the stroke burden occurring in low-income and middle-income countries. Infectious diseases are still a great health problem in developing countries and it is possible that the proportion of infection-related strokes is greater in these nations. Read More

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http://dx.doi.org/10.1097/WCO.0000000000000641DOI Listing
February 2019
1 Read

Comparative evaluation of Xpert MTB/RIF assay with multiplex polymerase chain reaction for the diagnosis of tuberculous meningitis.

Tuberculosis (Edinb) 2018 12 6;113:38-42. Epub 2018 Sep 6.

Department of Medicine & Mycobacteriology Laboratory, National Jewish Health, Denver, CO, USA.

Background: Rapid and specific diagnosis of tuberculous meningitis (TBM) is of paramount importance to decrease morbidity and mortality. Therefore, the present study was undertaken to compare the efficacy of Xpert MTB/RIF assay (GXpert) and multiplex PCR (MPCR) using three targets (IS6110, MPB64 and protein B) for diagnosing tuberculous meningitis.

Methods: GXpert and MPCR were performed on cerebrospinal fluid samples of 225 patients out of which 80 were culture-positive confirmed cases of TBM, 100 were 'suspected' cases of TBM and 45 were non-TBM controls. Read More

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http://dx.doi.org/10.1016/j.tube.2018.09.002DOI Listing
December 2018
5 Reads

Levofloxacin Pharmacokinetics/Pharmacodynamics, Dosing, Susceptibility Breakpoints, and Artificial Intelligence in the Treatment of Multidrug-resistant Tuberculosis.

Clin Infect Dis 2018 Nov;67(suppl_3):S293-S302

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

Background: Levofloxacin is used for the treatment of multidrug-resistant tuberculosis; however the optimal dose is unknown.

Methods: We used the hollow fiber system model of tuberculosis (HFS-TB) to identify 0-24 hour area under the concentration-time curve (AUC0-24) to minimum inhibitory concentration (MIC) ratios associated with maximal microbial kill and suppression of acquired drug resistance (ADR) of Mycobacterium tuberculosis (Mtb). Levofloxacin-resistant isolates underwent whole-genome sequencing. Read More

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http://dx.doi.org/10.1093/cid/ciy611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260169PMC
November 2018
2 Reads
8.886 Impact Factor

Gatifloxacin Pharmacokinetics/Pharmacodynamics-based Optimal Dosing for Pulmonary and Meningeal Multidrug-resistant Tuberculosis.

Clin Infect Dis 2018 Nov;67(suppl_3):S274-S283

Center for Infectious Diseases Research and Experimental Therapeutics, Baylor Research Institute, Baylor University Medical Center, Dallas, Texas.

Background: Gatifloxacin is used for the treatment of multidrug-resistant tuberculosis (MDR-TB). The optimal dose is unknown.

Methods: We performed a 28-day gatifloxacin hollow-fiber system model of tuberculosis (HFS-TB) study in order to identify the target exposures associated with optimal kill rates and resistance suppression. Read More

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http://fdslive.oup.com/www.oup.com/pdf/production_in_progres
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http://dx.doi.org/10.1093/cid/ciy618DOI Listing
November 2018
3 Reads

Intensified antibiotic treatment of tuberculosis meningitis.

Expert Rev Clin Pharmacol 2018 Nov 24:1-22. Epub 2018 Nov 24.

f Department of Internal Medicine and Radboud Center for Infectious Diseases , Radboud university medical center , Nijmegen , the Netherlands.

Introduction: Meningitis is the most severe manifestation of tuberculosis, resulting in death or disability in over 50% of those affected, with even higher morbidity and mortality among patients with HIV or drug resistance. Antimicrobial treatment of Tuberculous meningitis (TBM) is similar to treatment of pulmonary tuberculosis, although some drugs show poor central nervous system penetration. Therefore, intensification of antibiotic treatment may improve TBM treatment outcomes. Read More

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https://www.tandfonline.com/doi/full/10.1080/17512433.2019.1
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http://dx.doi.org/10.1080/17512433.2019.1552831DOI Listing
November 2018
5 Reads

Prioritization of risk groups for influenza vaccination in resource limited settings - A case study from South Africa.

Vaccine 2019 Jan 22;37(1):25-33. Epub 2018 Nov 22.

Centre for Respiratory Diseases and Meningitis, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa; School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.

Background: Due to competing health priorities, low- and middle-income countries (LMIC) may need to prioritize between different influenza vaccine risk groups. Risk group prioritization may differ in LMIC based upon programmatic feasibility, country-specific prevalence of risk conditions and influenza-associated morbidity and mortality.

Methods: In South Africa, we collected local disease burden data (both published and unpublished) and published vaccine efficacy data in risk groups and healthy adults. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X183157
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http://dx.doi.org/10.1016/j.vaccine.2018.11.048DOI Listing
January 2019
10 Reads

A Randomized Study Comparing Endoscopic Third Ventriculostomy versus Ventriculoperitoneal Shunt in the Management of Hydrocephalus Due to Tuberculous Meningitis.

Asian J Neurosurg 2018 Oct-Dec;13(4):1140-1147

Department of Neurosurgery, Post Graduate Institute of Medical Education and Research (PGIMER) and Dr Ram Manohar Lohia Hospital, New Delhi, India.

Objectives: The objective of this study was to compare safety and efficacy of endoscopic third ventriculostomy (ETV) versus ventriculoperitoneal (VP) shunt in the treatment of hydrocephalus in tuberculous meningitis (TBM) and to assess clinical and radiological profiles of patients with TBM that would be better suited to either VP shunt or ETV.

Methods: This study was a single-center randomized prospective study on 52 patients with TBM hydrocephalus in the pediatric age group (<18 years of age). Patients included in the study were randomized into undergo either VP shunt or ETV. Read More

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http://dx.doi.org/10.4103/ajns.AJNS_107_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208215PMC
November 2018
13 Reads

Paediatric deaths in a tertiary government hospital setting, Malawi.

Paediatr Int Child Health 2018 Nov 19:1-9. Epub 2018 Nov 19.

g Centre for Medical Education , Queen's University , Belfast , UK.

Background: Malawisuccessfully achieved Millennium Development Goal (MDG) four by decreasing the under-5 mortality rate by two-thirds in 2012. Despite this progress child mortality is still high and in 2013, the leading causes of death in under-5s were malaria, acute respiratory infections and HIV/AIDS.

Aims: To determine the causes of inpatient child death including microbiological aetiologies in Malawi. Read More

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https://www.tandfonline.com/doi/full/10.1080/20469047.2018.1
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http://dx.doi.org/10.1080/20469047.2018.1536873DOI Listing
November 2018
12 Reads

Cytokine profiles in cerebrospinal fluid of patients with meningitis at a tertiary general hospital in China.

J Microbiol Immunol Infect 2018 Nov 9. Epub 2018 Nov 9.

Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China. Electronic address:

Background: There has been a great deal of evidence indicating that cytokines participate in meningeal inflammation. Different cytokine profiles may be presented in central nervous system (CNS) infection due to different pathogens. We have attempted to investigate cytokine profiles in cerebrospinal fluid (CSF) of patients with CNS infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S16841182183047
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http://dx.doi.org/10.1016/j.jmii.2018.08.019DOI Listing
November 2018
10 Reads
2.349 Impact Factor

Rupture of a Middle Meningeal Artery Pseudoaneurysm in Moyamoya Syndrome Related with Tuberculous Meningitis.

J Cerebrovasc Endovasc Neurosurg 2018 Sep 30;20(3):187-190. Epub 2018 Sep 30.

Department of Neurosurgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

We report a rare case of a patient with Moyamoya syndrome who presented with intracerebral hemorrhage resulting from rupture of a middle meningeal artery pseudoaneurysm. This 38-year-old woman was unconscious and hemiplegic when she was admitted to our hospital. The patient had mental retardation as a result of tuberculous meningitis infection at the age of one year. Read More

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http://dx.doi.org/10.7461/jcen.2018.20.3.187DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199402PMC
September 2018
2 Reads

Seizures in tuberculous meningitis.

Epilepsy Res 2018 12 25;148:90-95. Epub 2018 Oct 25.

Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.

Objective: We report the frequency of seizure, its possible mechanisms and effect of seizure on the outcome of tuberculous meningitis (TBM).

Methods: Seventy-nine patients with TBM admitted during 2014-2017 were evaluated. The seizures were categorized as per International League Against Epilepsy as well as into early (within 1 month of meningitis) and late (>1 month) seizure. Read More

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http://dx.doi.org/10.1016/j.eplepsyres.2018.10.005DOI Listing
December 2018
5 Reads

An Infant with Xpert Confirmed TB Meningitis in Central Viet Nam.

J Clin Med 2018 Oct 29;7(11). Epub 2018 Oct 29.

Discipline of Paediatrics and Adolescent Medicine, The Children's Hospital at Westmead, The University of Sydney, Westmead 2145, Australia.

A 5-month-old boy presented with a focal seizure. Disseminated (miliary) tuberculosis (TB) was diagnosed on chest radiograph and TB meningitis was confirmed using Xpert MTB/RIF. The case represents the first instance of cerebrospinal fluid Xpert MTB/RIF testing in children in central Viet Nam. Read More

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http://www.mdpi.com/2077-0383/7/11/397
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http://dx.doi.org/10.3390/jcm7110397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262475PMC
October 2018
14 Reads

Adjunctive dexamethasone for the treatment of HIV-uninfected adults with tuberculous meningitis stratified by Leukotriene A4 hydrolase genotype (LAST ACT): Study protocol for a randomised double blind placebo controlled non-inferiority trial.

Wellcome Open Res 2018 20;3:32. Epub 2018 Mar 20.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Tuberculosis kills more people than any other bacterial infection worldwide. In tuberculous meningitis (TBM), a common functional promoter variant (C/T transition) in the gene encoding leukotriene A4 hydrolase (LTA4H), predicts pre-treatment inflammatory phenotype and response to dexamethasone in HIV-uninfected individuals. The primary aim of this study is to determine whether LTA4H genotype determines benefit or harm from adjunctive dexamethasone in HIV-uninfected Vietnamese adults with TBM. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.14007.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6182672PMC
March 2018
15 Reads

Management of complex tuberculosis cases: a focus on drug-resistant tuberculous meningitis.

Expert Rev Anti Infect Ther 2018 Nov;16(11):813-831

a Department of Neurology , King George Medical University , Lucknow , India.

Introduction: Drug-resistant tuberculous meningitis has been reported worldwide. Isoniazid mono-resistance is the most frequent cause of drug-resistant tuberculous meningitis, a life-threatening disease. Extensive drug-resistant tuberculous meningitis has also been reported in some isolated case reports. Read More

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https://www.tandfonline.com/doi/full/10.1080/14787210.2018.1
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http://dx.doi.org/10.1080/14787210.2018.1540930DOI Listing
November 2018
13 Reads

Frequency and Impact of Cerebral Infarctions in Patients With Tuberculous Meningitis.

Stroke 2018 Oct;49(10):2288-2293

Pathology and Microbiology (M.A.B.), Aga Khan University, Karachi, Pakistan.

Background and Purpose- Cerebral infarctions complicate a variable proportion of tuberculous meningitis (TBM) cases and adversely affect outcomes. The objective of this study was to evaluate the predictors of cerebral infarcts in patients with TBM and to assess their impact on mortality. Methods- The study was based on a retrospective chart review of all patients with TBM admitted to a tertiary care hospital between 2002 and 2013. Read More

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https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.021301
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http://dx.doi.org/10.1161/STROKEAHA.118.021301DOI Listing
October 2018
6 Reads

A comparison of model selection methods for prediction in the presence of multiply imputed data.

Biom J 2018 Oct 23. Epub 2018 Oct 23.

Biostatistics group, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

Many approaches for variable selection with multiply imputed data in the development of a prognostic model have been proposed. However, no method prevails as uniformly best. We conducted a simulation study with a binary outcome and a logistic regression model to compare two classes of variable selection methods in the presence of MI data: (I) Model selection on bootstrap data, using backward elimination based on AIC or lasso, and fit the final model based on the most frequently (e. Read More

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http://doi.wiley.com/10.1002/bimj.201700232
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http://dx.doi.org/10.1002/bimj.201700232DOI Listing
October 2018
13 Reads