4,442 results match your criteria Tuberculosis Miliary


Papillary thyroid carcinoma presenting as miliary nodules on chest roentgenogram in the paediatric setting: A case report.

Int J Surg Case Rep 2020 Jun 13;72:322-325. Epub 2020 Jun 13.

Division of Anatomical Pathology, Faculty of Health Sciences, University of Cape Town and National Health Laboratory Service - Red Cross War Memorial Children's Hospital, Cape Town, South Africa. Electronic address:

Introduction: Papillary thyroid carcinoma (PTC) is the most common carcinoma to occur in childhood with a peak incidence between 11-17 years, and typically presents with advanced locoregional disease. Pulmonary metastases are seen in up to 46% of cases and should enter the differential diagnosis of miliary nodules seen on chest roentgenogram, even in regions where tuberculosis is endemic.

Presentation Of Case: An 11-year-old male presented with a short history of cough, shortness of breath and constitutional symptoms. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.058DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305368PMC

Of tuberculosis and non-tuberculous mycobacterial infections - a comparative analysis of epidemiology, diagnosis and treatment.

J Biomed Sci 2020 Jun 17;27(1):74. Epub 2020 Jun 17.

Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ, United States.

Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent epidemiological studies have shown the emergence of non-tuberculous mycobacteria (NTM) species in causing lung diseases in humans. Although more than 170 NTM species are present in various environmental niches, only a handful, primarily Mycobacterium avium complex and M. Read More

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http://dx.doi.org/10.1186/s12929-020-00667-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297667PMC

Hepatitis in children with tuberculosis: a case report and review of the literature.

BMC Pulm Med 2020 Jun 16;20(1):173. Epub 2020 Jun 16.

Division of Pediatric Infectious Diseases, Nationwide Children's Hospital, Columbus, OH, USA.

Background: Hepatitis in young children with tuberculosis (TB) outside miliary TB is not well described and represents a challenge because of the hepatotoxicity associated with first-line anti-TB treatment.

Case Presentation: We report an antibiotic naïve 13-month-old male from Nepal with pulmonary TB and hepatitis, who improved after TB treatment. We also performed a literature review for TB-associated hepatitis in children. Read More

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http://dx.doi.org/10.1186/s12890-020-01215-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7298953PMC

A Case of Miliary Perinatal Tuberculosis in a Preterm Newborn Infant Presenting as Peritonitis.

Cureus 2020 May 9;12(5):e8036. Epub 2020 May 9.

Pediatrics Section, Marie Curie Children's Emergency Hospital, Bucharest, ROU.

Perinatal tuberculosis (TB) is a rare disease with nonspecific clinical symptoms that can result in delayed treatment, and contribute to high morbidity and mortality. We report a case of perinatal TB in a 25-day-old newborn who presented with fever, respiratory distress, disseminated intravascular coagulation (DIC), and marked abdominal distension with hepatosplenomegaly. Further workup revealed culture negative sepsis, peritonitis, and diffuse nodular infiltrate in the lungs, liver, and spleen. Read More

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http://dx.doi.org/10.7759/cureus.8036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282365PMC

Early diagnosis of miliary tuberculosis in a hemodialysis patient by combining two interferon-γ-release assays: a case report.

BMC Nephrol 2020 Jun 4;21(1):214. Epub 2020 Jun 4.

Laboratory of Vaccinology and Mucosal Immunity, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium.

Background: Patients with end-stage renal disease undergoing chronic hemodialysis (HD) are at high risk to develop tuberculosis (TB) associated with a high mortality rate. TB diagnosis is often delayed due to non-specific symptoms, frequent extra-pulmonary manifestations, and rare microbiological confirmation. This case report illustrates the clear added value of combined interferon-γ -release assays (IGRA) in response to different mycobacterial antigens for an early diagnosis of TB in HD patients. Read More

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http://dx.doi.org/10.1186/s12882-020-01875-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7273678PMC

Internal thoracic lymphadenopathy and pulmonary tuberculosis.

Clin Imaging 2020 May 3;67:11-14. Epub 2020 May 3.

Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, United States of America. Electronic address:

Objective: Internal thoracic lymphadenopathy (ITL) has been associated with malignancies and non-tuberculous empyema. However, the association between ITL and active pulmonary tuberculosis (PTB) and the correlation between ITL and other imaging characteristics of active PTB has not been examined.

Materials And Methods: A retrospective cohort study comprising 137 adults with active PTB who had a concomitant chest CT over a seven-year period was conducted. Read More

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http://dx.doi.org/10.1016/j.clinimag.2020.04.033DOI Listing

Extra-central nervous system tuberculosis in HIV-uninfected patients of tuberculous meningitis: A prospective evaluation.

J Infect Public Health 2020 May 18. Epub 2020 May 18.

Department of Neurology, King George Medical University, Lucknow, Uttar Pradesh, 226003, India.

Objective: Disseminated tuberculosis is characterized with involvement of two or more non-contiguous sites. In this work we evaluated patients of tuberculous meningitis for possible extra-central nervous system tuberculosis.

Method: This prospective observational study was performed at a tertiary care institute in Northern India. Read More

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http://dx.doi.org/10.1016/j.jiph.2020.04.011DOI Listing

Characteristics Indicative of Tuberculosis/HIV Coinfection in a High-Burden Setting: Lessons from 13,802 Incident Tuberculosis Cases in Harare, Zimbabwe.

Am J Trop Med Hyg 2020 May 18. Epub 2020 May 18.

Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan.

Country-specific interventions targeting high-risk groups are necessary for a global reduction in Tuberculosis (TB)/HIV burden. We analyzed the data of 13,802 TB cases diagnosed in Harare, Zimbabwe, during 2013-2017. Pearson's chi-square tests and multivariate logistic regression models were used to identify patient characteristics significantly associated with TB/HIV coinfection. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0856DOI Listing

Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male.

Case Rep Pathol 2020 27;2020:6247920. Epub 2020 Mar 27.

Department of Pathology and Laboratory Medicine, University of Texas Health, 7703 Floyd Curl Drive, MC#7750, San Antonio, Texas 78229, USA.

Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The imaging findings in the early phase of disease can be mistaken for miliary tuberculosis or sarcoidosis. Read More

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http://dx.doi.org/10.1155/2020/6247920DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204375PMC

Disseminated Histoplasmosis and Miliary Tuberculosis Imitating Colon Cancer in Patient with HIV Who Refuses to Antirretroviral Treatment.

Mycopathologia 2020 Jun 8;185(3):583-586. Epub 2020 May 8.

Facultad de Medicina, Universidad Nacional del Centro del Perú, Avenue Mariscal Castilla 3909, 1206, Huancayo, Perú.

Simultaneous infection with histoplasmosis and miliary tuberculosis is rare and mainly affects people with severe immunosuppression, they can present very diverse clinical forms, similar to other infectious and neoplastic pathologies. We present the case of a 27-year-old woman diagnosed with HIV infection for 08 years who refuses to receive antiretroviral treatment (ART) and conceals her diagnosis, comes to the Hospital for pain, abdominal distension and ulcer in the oral cavity. The patient was diagnosed with likely cancer by presenting irregular intestinal thickening with homogeneous gray pattern in colon tomography and signs of intestinal obstruction, that after hemicolectomy was evidenced histoplasmosis in the pathological study, during the treatment with amphotericin B deoxycholate and improvement of the oral ulcer, the patient presented dyspnea, micronodular pattern on the chest radiograph that had not previously existed and the lipoarabinomanan antigen in the urine was positive for tuberculosis. Read More

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http://dx.doi.org/10.1007/s11046-020-00437-wDOI Listing

Radiological significance of high-resolution computed tomography for elderly pulmonary tuberculosis patients - an analysis with culture test.

Pol J Radiol 2020 6;85:e125-e131. Epub 2020 Mar 6.

Central Research Laboratory, Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, India.

Purpose: Pulmonary tuberculosis (PTB) is one of the major health problems in the elderly population, causing significant morbidity and mortality. The aim of this study is to evaluate the significance of the high-resolution computed tomography (HRCT) modality for the diagnosis of PTB, in comparison to culture test.

Material And Methods: Thoracic HRCT images of the study population, comprising 124 patients clinically suspected for PTB with smear and culture reports, were analysed for sensitivity and specificity of the HRCT test. Read More

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http://dx.doi.org/10.5114/pjr.2020.93697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7172224PMC

Miliary opacities in pulmonary sarcoidosis.

Respirol Case Rep 2020 Jul 18;8(5):e00563. Epub 2020 Apr 18.

Department of Respiratory Medicine Tsuboi Hospital Koriyama City Japan.

Pulmonary sarcoidosis should be considered in the differential diagnosis of miliary opacities in bilateral upper lobes predominance. Read More

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http://dx.doi.org/10.1002/rcr2.563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7165362PMC

Post-Renal Transplant Miliary Mottling: Not Always Tuberculosis.

Indian J Nephrol 2020 Mar-Apr;30(2):121-124. Epub 2020 Jan 3.

Department of Nephrology and Microbiology, Government Stanley Medical College, The TN Dr. MGR Medical University, Chennai, Tamil Nadu, India.

A 28-year-old male, 3 years post renal transplant with stable graft function, presented with vomiting for 2 days. He had graft dysfunction and graft biopsy done revealed acute cell - mediated rejection BANFF-IA. After receiving glucocorticoids for rejection, he developed severe enterocolitis and impending respiratory failure. Read More

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http://dx.doi.org/10.4103/ijn.IJN_141_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132843PMC
January 2020

Adenocarcinoma of the Lung Mimicking Miliary Tuberculosis.

Case Rep Oncol 2020 Jan-Apr;13(1):139-144. Epub 2020 Feb 13.

Department of Medical Oncology-Hematology, Hamad Medical Corporation Qatar, Doha, Qatar.

Miliary shadows on chest imaging have wide differential diagnoses. The most common etiology is infectious, such as miliary tuberculosis (TB) and histoplasmosis, but miliary shadows can be the presentation of sarcoidosis, pneumoconiosis, and secondary metastasis to the lungs from primary cancers of the thyroid, kidney, and trophoblasts as well as sarcomas. Here we present the case of a 35-year-old Indian male who presented with a 2-month history of dry cough and shortness of breath. Read More

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http://dx.doi.org/10.1159/000505685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098354PMC
February 2020

Fatal congenital tuberculosis owing to late diagnosis of maternal tuberculosis: case report and review of congenital tuberculosis in China.

Paediatr Int Child Health 2020 Mar 20:1-5. Epub 2020 Mar 20.

Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Anhui, China.

Congenital tuberculosis (TB) is rare and the prognosis is poor if not detected early. The diagnosis is often delayed owing to non-specific clinical presentation, misdiagnosis and undiagnosed maternal TB during pregnancy. A 12-day-old girl presented with a 5-day history of fever, cough, poor feeding and respiratory distress. Read More

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http://dx.doi.org/10.1080/20469047.2020.1743932DOI Listing

Towards more accurate F-fluorodeoxyglucose positron emission tomography (F-FDG PET) imaging in active and latent tuberculosis.

Int J Infect Dis 2020 Mar 27;92S:S85-S90. Epub 2020 Feb 27.

Institute of Nuclear Medicine, UCLH NHS Foundation Trust, 235 Euston Road, London NW1 2BU, United Kingdom. Electronic address:

Tuberculosis (TB) is one of the leading causes of death worldwide. Although the disease is curable and preventable, it is underdiagnosed in many parts of the world. Positron emission tomography (PET) imaging using F-FDG in TB can localise disease sites and the extent of disease. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.02.017DOI Listing

Tubercular granuloma mimicking pyogenic liver abscess.

J Family Med Prim Care 2020 Jan 28;9(1):424-427. Epub 2020 Jan 28.

Department of Medicine, AIIMS Rishikesh, Uttarakhand, India.

Hepatic Tuberculosis (TB) is extremely rare without miliary involvement in immunocompetent patients. Even in countries like India where TB is a major public health problem only few cases have been diagnosed and treated. We report a case of an immunocompetent patient who presented with undiagnosed pyrexia of 11 days, was initially diagnosed as pyogenic liver abscess, he did not responded to treatment and on liver biopsy was diagnosed as hepatic tuberculoma. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_630_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014858PMC
January 2020

From Diagnosis to Treatment of Pediatric Tuberculosis: Ten Years Experience in a Single Institution.

Clin Pediatr (Phila) 2020 May 22;59(4-5):476-482. Epub 2020 Feb 22.

Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey.

. To describe the patient characteristics, clinical-epidemiologic-microbiologic profile, and treatment outcomes, and to draw attention to tuberculosis (TB) in Turkey. . Read More

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http://dx.doi.org/10.1177/0009922820906488DOI Listing

A case of miliary tuberculosis presenting as massive hepatosplenomegaly and fatal hepatic failure.

IDCases 2020 29;19:e00707. Epub 2020 Jan 29.

Department of Respiratory Medicine, Tokyo Medical University Ibaraki Medical Center, 3-20-1 Chuou, Ami, Inashiki, Ibaraki, 300-0395, Japan.

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http://dx.doi.org/10.1016/j.idcr.2020.e00707DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011022PMC
January 2020

Central nervous system tuberculoma with miliary tuberculosis in the elderly.

IDCases 2020 29;19:e00710. Epub 2020 Jan 29.

Department of Neurology, International University of Health and Welfare Hospital, 537-3, Iguchi, Nasushiobara, Tochigi, 329-2763, Japan.

The aging phenomenon of tuberculosis (TB) patients is recognized all over the world, but no country is as prominent as Japan. Central nervous system (CNS) TB includes clinical entities: tuberculous meningitis, intracranial tuberculoma, and clinical features of CNS TB in the elderly may be atypical, non-specific, and confused with concomitant age-related diseases. Atypical clinical manifestations of TB in older persons can result in delay in diagnosis and initiation of treatment. Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00710DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005458PMC
January 2020

Hemophagocytic Lymphohistiocytosis Induced Cytokine Storm Secondary to Human Immunodeficiency Virus Associated Miliary Tuberculosis.

Cureus 2020 Jan 7;12(1):e6589. Epub 2020 Jan 7.

Hematology/Oncology, Cooper University Medical Center, Camden, USA.

Hemophagocytic lymphohistiocytosis (HLH) is a rarely diagnosed fatal inflammatory disease associated with an overactive immune system. It occurs in a host of conditions, with human immunodeficiency virus (HIV) being a rare but serious cause, usually occurring in patients with acquired immunodeficiency syndrome (AIDS). The diagnosis of HLH can be very difficult, as it presents with vague signs and symptoms, which can be present in multiple diseases. Read More

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http://dx.doi.org/10.7759/cureus.6589DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001132PMC
January 2020

Tuberculosis among patients treated with TNF inhibitors for rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis in Slovenia: a cohort study.

BMJ Open 2020 02 5;10(2):e034356. Epub 2020 Feb 5.

Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Objectives: This study aimed to assess the risk of tuberculosis (TB) in patients with rheumatoid arthritis (RA), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) treated with any of the commercially available tumour necrosis factor inhibitors (TNFis) in Slovenia.

Design: This is a cohort, registry (biorx.si) cross-linked with the Slovenian National TB Registry. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-034356DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7045120PMC
February 2020

Abdominal Tuberculosis Mimicking Cancer Clinically and on Fluorodeoxyglucose (FDG)-Positron Emission Tomography (PET) Imaging: A Two-Case Series.

Am J Case Rep 2020 Feb 5;21:e918901. Epub 2020 Feb 5.

Liver Surgery at Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.

BACKGROUND Miliary tuberculosis (MT) is the disseminated form of tuberculosis (TB) and it is a potentially fatal condition. Diagnosis is often delayed because symptoms are typically nonspecific or absent, and misdiagnosis in favor of other diseases is common. We report 2 cases of disseminated TB that were diagnosed during or after surgeries performed for other suspected diseases. Read More

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http://dx.doi.org/10.12659/AJCR.918901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020736PMC
February 2020

Role of Fiberoptic Bronchoscopy in the Rapid Diagnosis of Sputum Smear-negative Disseminated Tuberculosis with Pulmonary Miliary Infiltrates.

Oman Med J 2020 Jan 15;35(1):e87. Epub 2020 Jan 15.

Pulmonary Division, Department of Medicine, Hamad General Hospital, Doha, Qatar.

Objectives: We sought to evaluate the role of bronchoscopy-related procedures such as bronchoalveolar lavage (BAL), bronchial wash (BW), bronchial brush (B brush), transbronchial biopsy (TBB), and post-bronchoscopy sputum (PBS), alone or in combination, in the rapid diagnosis of negative sputum smear disseminated tuberculosis (TB).

Methods: We performed a secondary post hoc analysis of data collected from our previous study entitled "Disseminated tuberculosis among adult patients admitted to Hamad General Hospital, Qatar: A five-year hospital-based study" with a modified objective.

Results: We identified 27 patients. Read More

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http://dx.doi.org/10.5001/omj.2020.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6975253PMC
January 2020

[Tuberculosis and immune reconstitution inflammatory syndrome. Pediatric case].

Arch Argent Pediatr 2020 02;118(1):e39-e42

Cuidados Intermedios y Moderados, Hospital Nacional de Pediatría "Prof. Dr. Juan P. Garrahan", Ciudad Autónoma de Buenos Aires.

Tuberculosis is a very frequent disease in our environment. Although early detection and adequate treatment achieve cure in most patients, the difficulty in diagnosis, the abandonment of treatment and the appearance of resistance to traditional drugs generate that at present it continues to represent an important public health problem. In Argentina, the morbidity rate is 25/100,000 inhabitants, with a slight increase in mortality. Read More

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http://dx.doi.org/10.5546/aap.2020.e39DOI Listing
February 2020

Pulmonary Sarcoidosis Presenting with Miliary Opacities.

Curr Med Imaging Rev 2019 ;15(1):81-83

Internal Medicine and Critical Subacute Care Unit, Medicine Geriatric-Rehabilitation Department, University-Hospital of Parma, Parma, Italy.

Background: Lung lesions often appear in patients with sarcoidosis; however, miliary opacities are rare. We present the case of a 55-year-old Indian man who presented with dyspnea and low-grade fever.

Discussion: Miliary Tuberculosis (TB) was initially suspected, despite the direct microscopic examination from bronchoalveolar lavage was negative for acid-fast bacilli because imaging showed miliary opacities, and transbronchial lung biopsy revealed the presence of typical caseating granulomas. Read More

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http://dx.doi.org/10.2174/1573405614666180806141415DOI Listing
January 2019

Ground-glass opacity as a paradoxical reaction in miliary tuberculosis: A case report and review of the literature.

IDCases 2020 19;19:e00685. Epub 2019 Dec 19.

Department of Respiratory Medicine, Saiseikai-Noe Hospital, Osaka, Japan.

A paradoxical reaction (PR) is an excessive immune response occurring during antitubercular therapy (ATT), but is rare in patients with miliary tuberculosis. A 78-year-old woman complained of general malaise, loss of appetite, and fever for 10 days. Chest computed tomography (CT) showed diffuse, bilateral, discrete miliary nodules. Read More

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http://dx.doi.org/10.1016/j.idcr.2019.e00685DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939021PMC
December 2019

Reactivation of latent tuberculosis infection induced by cabazitaxel in a patient with prostate cancer: A case report.

Medicine (Baltimore) 2019 Dec;98(51):e18436

Department of Urology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka, Japan.

Rationale: Latent tuberculosis infection (LTBI) describes the dormant state of tuberculosis (TB), in which persistent immune-related interaction between TB and T-cells maintain its state. Cabazitaxel (CBZ) is reported to improve overall survival in patients with castration-resistant prostate cancer (CRPC) after progression observed in regimens including docetaxel. CBZ is known for severe myelosuppression; however there is no recommendation for the treatment of LTBI before CBZ treatment. Read More

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http://dx.doi.org/10.1097/MD.0000000000018436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6940062PMC
December 2019

The dilemma in a case of immune thrombocytopenia in a patient with human immunodeficiency virus on antituberculosis treatment for miliary pulmonary tuberculosis.

Oxf Med Case Reports 2019 Nov 9;2019(11):486-489. Epub 2019 Dec 9.

Internal Medicine Department, Faculty of Medicine, Pelita Harapan University, Boulevard Jendral Sudirman, Lippo Karawaci, Tangerang, Banten 15811, Indonesia.

The multifactorial mechanisms of immune thrombocytopenia (ITP) in patients with human immunodeficiency virus (HIV) and tuberculosis (TB) could be caused by HIV, TB or anti-TB drugs. No patients with HIV and opportunistic infection of miliary pulmonary TB who developed thrombocytopenia after treatment with anti-TB drugs have been reported. A 47-year-old woman with HIV/acquired immunodeficiency syndrome and miliary TB with normal platelet count (229 000/μL) started anti-TB drugs (rifampicin, isoniazid, pyrazinamide and ethambutol). Read More

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http://dx.doi.org/10.1093/omcr/omz119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6902628PMC
November 2019

[Disseminated tuberculosis mimicking metastatic gastric cancer - a case report].

Z Gastroenterol 2019 Dec 11;57(12):1487-1492. Epub 2019 Dec 11.

Technische Universität München, Fakultät für Medizin, Klinikum rechts der Isar, Klinik und Poliklinik für Innere Medizin II.

Increasing numbers of active tuberculosis in Germany were recorded in the last years. Thus, also extrapulmonary manifestations of tuberculosis gain clinical significance as differential diagnoses, especially when a metastatic tumor disease is suspected. We report the case of a 77-year-old male patient who presented with unilateral leg pain and B symptoms. Read More

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http://dx.doi.org/10.1055/a-1030-4781DOI Listing
December 2019

Prevalence of active tuberculosis infection in transplant recipients: A systematic review and meta-analysis.

Microb Pathog 2020 Feb 2;139:103894. Epub 2019 Dec 2.

Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran. Electronic address:

Introduction: Tuberculosis (TB) is considered as a serious complication of organ transplant; therefore, the detection and appropriate treatment of active TB infection is highly recommended for the reduction of mortality in the future. The aim of this review was to conduct a systematic review and meta-analysis assessing the prevalence of active TB infection in transplant recipients (TRs).

Material And Methods: Electronic databases, including MEDLINE (via PubMed), SCOPUS and Web of Science were searched up to December 24, 2017. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.103894DOI Listing
February 2020

Tuberculosis disease in children and adolescents on therapy with anti-tumor necrosis factor-alpha agents: a collaborative, multi-centre ptbnet study.

Clin Infect Dis 2019 Dec 4. Epub 2019 Dec 4.

Department of Paediatrics, University of Melbourne, Parkville, Australia.

Background: In adults, anti-tumor-necrosis-factor (TNF)-α therapy is associated with progression of latent tuberculosis infection (LTBI) to tuberculosis (TB) disease. The existing paediatric data are very limited.

Methods: Retrospective multi-centre study within the Paediatric Tuberculosis Network European Trials Group, capturing patients <18 years who developed TB disease during anti-TNF-α therapy. Read More

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http://dx.doi.org/10.1093/cid/ciz1138DOI Listing
December 2019
8.886 Impact Factor

Tuberculous encephalopathy without meningitis: A rare manifestation of disseminated tuberculosis.

Int J Mycobacteriol 2019 Oct-Dec;8(4):406-408

Department of Medicine, VMMC and Safdarjung Hospital, Delhi, India.

Tuberculous (TB) encephalopathy is a rare presentation of the central nervous system tuberculosis. Its pathophysiology is believed to have an immune mechanism without any direct invasion by the tubercular bacilli. The clinical presentation is highly variable from mild illness to a potentially fatal one. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_131_19DOI Listing

Identificación de Mycobacterium bovis en pacientes con diagnóstico de tuberculosis pulmonar y extrapulmonar.

Gac Med Mex 2019 ;155(6):608-612

Secretaría de Salud, Instituto de Diagnóstico y Referencia Epidemiológicos. Ciudad de México, México.

Introduction: In Mexico, there is an alarming increase in the number of cases of Mycobacterium bovis infection on pulmonary and extrapulmonary presentations. The lack of timely identification triggers complications and increases mortality.

Objective: To know the frequency of M. Read More

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http://dx.doi.org/10.24875/GMM.19005407DOI Listing

Miliary tuberculosis and choroidal tuberculoma in a three-month old baby girl: Diagnosis and follow-up of a case.

Arch Soc Esp Oftalmol 2020 Jan 23;95(1):42-44. Epub 2019 Nov 23.

Servicio de Oftalmología, Hospital Universitario Central de Asturias, Oviedo, Asturias, España.

A three-month old baby girl presented with fever of unknown origin and with signs of worsening of this episode. Funduscopy showed a solitary choroidal lesion in her left eye, as well as extraocular lesions suggesting disseminated tuberculosis. A favourable outcome was achieved after quadruple antibiotic course and cortisone therapy. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.09.014DOI Listing
January 2020
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Mycobacterium tuberculosis infection in psoriatic patients treated with biologics: Real-world data from 18 Japanese facilities.

J Dermatol 2020 Feb 24;47(2):128-132. Epub 2019 Nov 24.

Department of Dermatology, Fukuoka University Faculty of Medicine, Fukuoka, Japan.

Although rare, tuberculosis has been reported with biologic treatment against psoriasis in Japan, a tuberculosis medium-burden country. Mycobacterial infection often develops after a long incubation period and might not have been adequately identified in clinical trials or post-marketing surveillance. To determine the real-world incidence of tuberculosis in psoriatic patients treated with biologics, we conducted a retrospective, multicenter, observational study in 18 facilities in Western Japan. Read More

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http://dx.doi.org/10.1111/1346-8138.15156DOI Listing
February 2020

Tuberculous Bronchoesophageal Fistula in Nephrotic Syndrome: A Silent Assassin.

Indian J Otolaryngol Head Neck Surg 2019 Oct 8;71(Suppl 1):104-106. Epub 2017 Apr 8.

Department of Otorhinolaryngology - Head and Neck Surgery, Maulana Azad Medical College and Associated Loknayak, G.N.E.C. and G.B. Pant Hospitals, New Delhi, India.

Tuberculosis, a global public health concern, is emerging as an important complication in children with nephrotic syndrome. We report a case of an adolescent with nephrotic syndrome who developed fatal miliary tuberculosis after initiation of steroid therapy, presenting as a bronchoesophageal fistula. The case highlights the importance of maintaining a high index of suspicion prior to starting immunosuppressive therapy in pediatric patients of nephrotic syndrome. Read More

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http://dx.doi.org/10.1007/s12070-017-1130-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6848563PMC
October 2019

Multiple Cranial Tuberculomas Without Meningitis in Two Infants With Miliary Tuberculosis.

Pediatr Infect Dis J 2019 12;38(12):e337-e339

Section of Pediatric Infectious Diseases, Baylor College of Medicine.

Magnetic resonance imaging may detect central nervous system involvement even when cerebrospinal fluid is normal and tests to detect Mycobacterium tuberculosis are negative. We describe 2 cases of miliary tuberculosis in young children with clinically unexpected central nervous system involvement. Magnetic resonance imaging of the brain should be considered part of the initial diagnostic workup for miliary tuberculosis in very young children. Read More

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http://dx.doi.org/10.1097/INF.0000000000002464DOI Listing
December 2019

Pulmonary alveolar microlithiasis and interstitial pneumonitis: a case report of the west of Iran.

Biomedicine (Taipei) 2019 Dec 14;9(4):28. Epub 2019 Nov 14.

Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran - Students Research Committee, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Pulmonary alveolar microlithiasis (PAM) is a rare disease with autosomal recessive inheritance. Herein, a 20-year-old lady referred to the hospital with a dry cough for two years. The chest X-ray findings were bilateral reticulonodular opacities in both lungs and honeycomb appearance suspicious for miliary tuberculosis and idiopathic pulmonary fibrosis. Read More

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http://dx.doi.org/10.1051/bmdcn/2019090428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6855191PMC
December 2019

Severe rifampicin-induced thrombocytopenia in a patient with miliary tuberculosis.

Pulmonology 2019 Nov 10. Epub 2019 Nov 10.

Headmaster of Infectious Diseases Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal.

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http://dx.doi.org/10.1016/j.pulmoe.2019.09.005DOI Listing
November 2019

Miliary tuberculosis and acute respiratory distress syndrome.

J Clin Tuberc Other Mycobact Dis 2019 Aug 25;16:100113. Epub 2019 Jun 25.

Aix-Marseille University, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.

Background: Miliary tuberculosis is a serious and uncommon form of tuberculosis due to hematogenous dissemination of .

Objective: This study aimed to describe the epidemiological and clinical features of miliary tuberculosis.

Patients And Methods: Data were collected from clinical files between August 2016 and July 2018. Read More

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http://dx.doi.org/10.1016/j.jctube.2019.100113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830161PMC

Miliary tuberculosis presenting as a choroidal mass and a tuberculosis screening review.

J Clin Tuberc Other Mycobact Dis 2018 Dec 11;13:13-16. Epub 2018 Oct 11.

Department of Hospital Medicine, 4500 San Pablo Rd. South, Jacksonville, FL 32224, USA.

Anti-tumor necrosis factor alpha (anti-TNF) therapy is a standard of care in the management of many inflammatory conditions. However, anti-TNF pharmaceuticals increases the risk of reactivating tuberculosis making screening for latent tuberculosis infection (LTBI) a requirement prior to initiating therapy.

Case: A middle-aged male from China with a past medical history of LTBI and Crohn's disease, previously on infliximab, presented to the United States for a second opinion on his abdominal pain. Read More

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http://dx.doi.org/10.1016/j.jctube.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830181PMC
December 2018

Disseminated Bacillus Calmette-Guérin (BCG) infection with pulmonary and renal involvement: A rare complication of BCG immunotherapy. A case report and narrative review.

Pulmonology 2019 Nov 8. Epub 2019 Nov 8.

Serviço de Medicina Interna, Centro Hospitalar Póvoa de Varzim/Vila do Conde, Portugal.

Intravesical Bacillus Calmette-Guérin (BCG) instillation is a mainstay of adjunctive therapy for superficial bladder cancer that increases length of disease progression-free survival. Although usually well tolerated, moderate to severe local and systemic infectious complications can occur with this immunotherapy. Diagnosis is difficult and often based on high clinical suspicion since in many cases Mycobacterium bovis is not isolated. Read More

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http://dx.doi.org/10.1016/j.pulmoe.2019.10.001DOI Listing
November 2019

Chest pain and a left parasternal soft tissue swelling in an immunocompetent refugee with disseminated tuberculosis.

Int J Infect Dis 2020 Jan 4;90:116-118. Epub 2019 Nov 4.

Clinical Epidemiology and Medical Statistics Unit, Department of Medical, Surgical and Experimental Medicine, University of Sassari, Sassari, Italy. Electronic address:

An immunocompetent migrant with chest pain was admitted to an Italian hospital. Computed tomography showed a left pectoral abscess and osteomyelitis of the sternum. The infection had spread into the anterior mediastinum near to the pericardium and the heart, where an atrial mass was confirmed by echocardiography. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.10.033DOI Listing
January 2020
2.330 Impact Factor

Radiological difference between new sputum-positive and sputum-negative pulmonary tuberculosis.

J Family Med Prim Care 2019 Sep 30;8(9):2810-2813. Epub 2019 Sep 30.

Associate Professor, Department of Pulmonary Medicine, AIIMS, Patna, Bihar, India.

Introduction: The current guidelines for the diagnosis of pulmonary tuberculosis (PTB) are based primarily on the demonstration of acid-fast bacilli (AFB) on sputum microscopy and chest radiograph. Knowing various radiological manifestations and their association with sputum microscopy findings can allow for early diagnosis and early initiation of treatment.

Aims: This study was performed to compare the chest radiograph features seen in sputum-positive and sputum-negative tuberculosis patients, respectively. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_652_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820435PMC
September 2019
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Oesophageal tuberculosis with concomitant candidiasis: a rare cause of dysphagia.

BMJ Case Rep 2019 Nov 2;12(11). Epub 2019 Nov 2.

Department of Surgery, Klerksdorp Tshepong Hospital Complex, Klerksdorp, North West, South Africa.

We present a case of a 23-year-old woman with dysphagia. She was reportedly newly diagnosed with HIV and had been initiated on antiretroviral treatment and tuberculosis (TB) prophylaxis. Oesophagogastroduodenoscopy revealed an irregular, ulcerative oesophageal lesion. Read More

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http://dx.doi.org/10.1136/bcr-2019-231435DOI Listing
November 2019

Classic Miliary TB.

QJM 2019 Oct 29. Epub 2019 Oct 29.

Assistant Professor, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh.

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http://dx.doi.org/10.1093/qjmed/hcz270DOI Listing
October 2019
1 Read

Peritoneal and upper genital tract tuberculosis.

Med Glas (Zenica) 2020 Feb 1;17(1). Epub 2020 Feb 1.

Gynecological Tumour Centre and European Competence Centre for Ovarian Cancer, Charité Universitätsmedizin Berlin, Germany.

Aim To present diagnostic and therapeutic possibilities for genital and peritoneal tuberculosis, mimicking to other pathological conditions, mainly, ovarian cancer. Methods Transabdominal and transvaginal ultrasound, computerized tomography, Ca125 and HE 4, ROMA- index (Risk of Ovarian Maligancy Algorithm index) and diagnostic laparoscopy were performed in order to diagnose genital tuberculosis in a female patient. Results: A 23-year-old woman from Morocco presented with intermitting abdominal pain, unintentional weight loss and primary infertility. Read More

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http://dx.doi.org/10.17392/1023-20DOI Listing
February 2020
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Retrospective Analysis of 28 Cases of Tuberculosis in Pregnant Women in China.

Sci Rep 2019 10 25;9(1):15347. Epub 2019 Oct 25.

Beijing Key Laboratory for Drug Resistant Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing Chest Hospital, Capital Medical University, Beijing, China.

While tuberculosis (TB) in pregnant women is reported globally, clinical data is unavailable in China. To describe clinical features and identify difficulties in the diagnosis of pregnancy-related TB, we performed a retrospective study of 28 TB inpatients at Beijing Chest Hospital. The results were presented in terms of interquartile range (IQR) for age, and medians and percentages with respect to the categorical variables. Read More

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http://dx.doi.org/10.1038/s41598-019-51695-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6814810PMC
October 2019
1 Read