1,055 results match your criteria Tuberculosis Genitourinary Tract


Activity of Repurposed Nitroxoline Against Clinically Isolated Mycobacteria Including Multidrug-Resistant .

Front Pharmacol 2022 26;13:906097. Epub 2022 May 26.

Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Medical Faculty and University Hospital of Cologne, Cologne, Germany.

Antimicrobial treatment options for mycobacterial infections are limited due to intrinsic resistance and the emergence of acquired resistance in . Isolates resisting first- and second line drugs are raising concerns about untreatable infections and make the development of new therapeutic strategies more pressing. Nitroxoline is an old oral antimicrobial that is currently repurposed for the treatment of urinary tract infection (UTI). Read More

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Identification of mycobacterial MPT-64 and ESAT-6 proteins in urogenital tuberculosis patients by real-time immuno-PCR.

Future Microbiol 2022 Jun 15. Epub 2022 Jun 15.

Centre for Biotechnology, Maharshi Dayanand University, Rohtak, 124001, India.

Diagnosis of urogenital tuberculosis (UGTB) is difficult and there is an immediate need to develop a reliable diagnostic test. A real-time immuno-PCR (RT-I-PCR) was developed to identify a cocktail of MPT-64 + ESAT-6 in both male/female UGTB patients comprising five confirmed cases, 40 clinically suspected cases and 37 non-TB controls, from whom mid-stream urine specimens were collected, while endometrial biopsies of female patients were obtained on day 1 of their menstrual cycle. Results obtained by RT-I-PCR were compared with I-PCR/ELISA and GeneXpert. Read More

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Diagnostic retardé de la tuberculose urinaire.

CMAJ 2022 Jun;194(23):E832-E833

Services des maladies infectieuses (Dhersin, Dubée), de radiologie (Bazeries) et de microbiologie (Chenouard), Hôpital universitaire Angers, Angers, France, Centre de recherche en cancérologie et immunologie intégrée Nantes Angers [CRCI2NA] (Dubée), Université de Nantes, Nantes, France.

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Unusual manifestations of extra-pulmonary tuberculosis: a pictorial essay.

Pol J Radiol 2022 10;87:e79-e86. Epub 2022 Feb 10.

Department of Pathology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.

Purpose: Tuberculosis is quite common in India. About 40% of all Indians are infected with mycobacterium tuberculosis, with 2.5 million active tuberculosis cases. Read More

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February 2022

Solitary tubercular renal cyst in a postpartum lady masquerading as an infected giant renal cyst with urosepsis.

Indian J Pathol Microbiol 2022 Jan-Mar;65(1):170-172

Department of Urology, Sri Narayani Hospital and Research Centre, Vellore, Tamil Nadu, India.

Renal tuberculosis presenting as renal cyst is rare. Diagnosing renal tuberculosis in pregnancy is usually delayed due to its atypical presentation. We present a 28-year-old postpartum lady who delivered a healthy baby one month back, with history of intermittent fever and chills. Read More

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February 2022

A Rare Case of Psoas Abscess Secondary to Mucinous Adenocarcinoma of the Appendix: A Case Report.

J Orthop Case Rep 2021 Aug;11(8):1-5

Department of Orthopaedics, Seth G.S Medical College and KEM Hospital, Mumbai. Maharashtra. India.

Introduction: Iliacus and psoas muscles are located in an extraperitoneal location forming the iliopsoas compartment. Iliopsoas abscess is a myositis involving this compartment. Pseudomyxoma peritonei is characterized by an abundant extracellular collection of mucin in the peritoneal cavity. Read More

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[Urethral microbiome in patients with pulmonary tuberculosis].

Urologiia 2021 12(6):66-71

Medical Center Avicenna, Novosibirsk, Russia.

Introduction: Treatment of tuberculosis involves long-term intake of several antimicrobial drugs, including that with a wide spectrum of action, which may affect the microflora of the urinary tract.

Aim: To determine the effect of long-term combination of antibiotic drugs on the microbiome of male urethra.

Materials And Methods: A total of 75 men were included in an open, prospective, non-comparative study, including 63 patients with pulmonary tuberculosis who received anti-tuberculosis therapy for at least 3 and no more than 5 months without urinary tract infections (main group) and 12 patients with non-infectious urological diseases (urolithiasis, benign prostatic hyperplasia) and normal urinalysis (comparison group). Read More

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December 2021

Isolated prostatic tuberculosis and review of literature.

Urol Case Rep 2022 Jan 29;40:101924. Epub 2021 Oct 29.

University Tunis Manar, Faculty of Medicine of Tunis, Department of Urology, La Rabta Hospital, Tunis, Tunisia.

Tuberculosis (TB) is one of the most important infectious diseases, particularly in the world. Amongst the genitourinary organs, prostatic TB is less common. We report an 68 year old patient, immunocompetent who presented obstructive and irritative symptoms of the lower urinary tract. Read More

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January 2022

Unilateral Testicular Tuberculosis: An Extra-Pulmonary Manifestation.

Cureus 2021 Oct 19;13(10):e18896. Epub 2021 Oct 19.

General Medicine, Bradford Royal Infirmary, Bradford, GBR.

The pathogenicity of causes it to most commonly manifest within the respiratory system (pulmonary tuberculosis); however, 15% of cases undergo extra-pulmonary spread to various organs. Genitourinary tuberculosis (GUTB) is a rare form of tuberculosis infection which has a propensity to affect the genitourinary tract, primarily affecting the kidneys, epididymis, seminal vesicles and prostate; however, 0.5% of cases result in infection of the testicles. Read More

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October 2021

Prostatic lithiasis complicating granulomatous prostatis of tuberculous origin: About a case report.

Urol Case Rep 2022 Jan 1;40:101875. Epub 2021 Oct 1.

Departement of Urology, La Rabta Hospital, Tunisia.

Urogenital tuberculosis remains a frequent disease in our country. It is the most common extra-pulmonary location. Prostatic involvement is extremely rare. Read More

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January 2022

[Surgical treatment of patients with urogenital tuberculosis].

Urologiia 2021 06(3):155-161

TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.

Despite the modest positive trends in the epidemic situation for tuberculosis, the incidence of extrapulmonary tuberculosis is not consistent. The relevance of urogenital tuberculosis remains high, as well as its social significance. Tuberculosis of the kidneys and urinary tract is often diagnosed late, when drug therapy is not enough and surgical treatment is required. Read More

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Imaging Manifestations of Genitourinary Tuberculosis.

Radiographics 2021 Jul-Aug;41(4):1123-1143. Epub 2021 May 28.

From the Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Campus Box 8131, St Louis, MO 63110 (M.N., M.Z., A.S.S., C.S.); Department of Radiology, Division of Body Imaging, University of Missouri Health System, Columbia, Mo (M.A.S.); Department of Radiology, Division of Body Imaging, Sindh Institute of Urology and Transplantation, Civil Hospital, Karachi, Pakistan (A.H.); Department of Imaging, Division of Body Imaging, Clinica Davila, Recoleta, Chile (C.V.); and Department of Radiology, Division of Abdominal Imaging, Mayo Clinic Arizona, Scottsdale, Ariz (C.O.M.).

The genitourinary region is one of the most common sites of extrapulmonary tuberculosis (TB) involvement. The imaging features of genitourinary TB are protean and can mimic other entities, including malignancy, and pose a diagnostic dilemma. Hematogenous seeding and lymphatic spread of mycobacteria from pulmonary, tonsillar, and nodal TB are implicated in the pathogenesis of genitourinary TB. Read More

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November 2021

The Differential Diagnosis of Sterile Pyuria in Pediatric Patients: A Review.

Authors:
Donald W Bendig

Glob Pediatr Health 2021 6;8:2333794X21993712. Epub 2021 May 6.

CHOC Children's Hospital, Orange, CA, USA.

Sterile pyuria is a common finding in pediatric patients. Literature describing the diagnoses as well as clinical characteristics of children with sterile pyuria is lacking. This review was performed to establish an evidence-based approach to the differential diagnosis by way of an extensive literature search. Read More

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Engineering Vaccines for Tissue-Resident Memory T Cells.

Adv Ther (Weinh) 2021 Apr 20;4(4). Epub 2021 Jan 20.

Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States.

In recent years, tissue-resident memory T cells (T) have attracted significant attention in the field of vaccine development. Distinct from central and effector memory T cells, T cells take up residence in home tissues such as the lung or urogenital tract and are ideally positioned to respond quickly to pathogen encounter. T have been found to play a role in the immune response against many globally important infectious diseases for which new or improved vaccines are needed, including influenza and tuberculosis. Read More

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Abdominal Ascites of Unknown Origin: Diagnostic Accuracy of Adenosine Deaminase for Tuberculous Peritonitis.

Case Rep Gastroenterol 2021 Jan-Apr;15(1):418-423. Epub 2021 Apr 6.

Gastroenterology, BronxCare Health System, Bronx, New York, USA.

The occurrence of tuberculosis (TB) is exceedingly rare in the United States (US), and incidence has steadily declined since 1993, but the pace of decline has slowed in recent years. The US TB rate during 2019 declined to 2.7 cases per 100,000 persons, the lowest level on record. Read More

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Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet's disease, and iBCG-induced ReA.

Rheumatol Int 2021 Aug 1;41(8):1387-1398. Epub 2021 May 1.

Department of Internal Medicine and Rheumatology, Juntendo University Koshigaya Hospital, Saitama, Japan.

Reactive arthritis (ReA) is a form of sterile arthritis that occurs secondary to an extra-articular infection in genetically predisposed individuals. The extra-articular infection is typically an infection of the gastrointestinal tract or genitourinary tract. Infection-related arthritis is a sterile arthritis associated with streptococcal tonsillitis, extra-articular tuberculosis, or intravesical instillation of bacillus Calmette-Guérin (iBCG) therapy for bladder cancer. Read More

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Diagnostic Value of PCR compared to Urine Culture for Urinary Tuberculosis in Adult Women: An Evidence-Based Case Report.

Acta Med Indones 2021 Jan;53(1):108-118

Department of Urology, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: genitourinary tuberculosis (GUTB) refers to a Mycobacterium tuberculosis infection of the urinary tract with clinical manifestation masquerading as various urological diagnostic entities. With an incidence rate of 192-232 per 100,000 individuals, current diagnoses have fallen short in comparison to the total incidence. Combined with an atypical and non-specific manifestation, a high false negative rate of acid-fast bacilli (AFB) staining, and long AFB culture duration has made diagnosis difficult. Read More

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January 2021

Diagnostic pitfalls of urogenital tuberculosis.

Trop Med Int Health 2021 07 6;26(7):753-759. Epub 2021 May 6.

Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University, London, UK.

Objectives: To describe characteristics, details of diagnosis and outcomes of urogenital tuberculosis (UGTB) in a low-prevalence country.

Methods: We conducted a retrospective observational study of 37 consecutive patients diagnosed with UGTB between 1 January 2014 and 31 October 2019 in an East London hospital.

Results: 68% (25/37) of patients were male and the median age was 42 years (IQR 34-55). Read More

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Biopsy-confirmed Genitourinary Tuberculosis in a Secondary Health Care Hospital: An Evidence-based Clinical Review.

Res Rep Urol 2021 17;13:133-137. Epub 2021 Mar 17.

Department of Urology, St. Carolus Hospital, Jakarta, Indonesia.

Introduction: Tuberculosis (TB) is a worldwide disease and remains a major public health problem in developing countries, with 95% of cases occurring in developing countries, including Indonesia. It is caused by , an acid-fast aerobic bacillus. When infects other than lung, it is called extrapulmonary tuberculosis (EPTB). Read More

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Genitourinary non-tuberculous mycobacterial (GU-NTM) infections: A single institution experience in South India.

Indian J Tuberc 2021 Jan 26;68(1):65-72. Epub 2020 Aug 26.

Former Senior Resident, Department of Urology, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham (Amrita University), Ponekkara, Cochin, Kerala, 682041, India.

Introduction: Non-tuberculous mycobacterial (NTM) infections are rarely reported, and more so with genitourinary infections. This retrospective study was designed to understand the proportion and behaviour of genitourinary non-tuberculous mycobacterial (GU-NTM) infections compared with genitourinary mycobacterial tuberculosis (GU-MTB) treated at a tertiary care hospital in South India.

Materials And Methods: The hospital records of every bacteriologically proved GU-MTB and GU-NTM infections treated at this centre from 2010 to 2016 were retrospectively reviewed. Read More

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January 2021

Unusual presentations of urogenital tuberculosis.

Int J Surg Case Rep 2020 25;77:769-772. Epub 2020 Nov 25.

Urology Department, Surgical Unit "Aghlabides" of Ibn Jazzar Hospital, Rue Hassan Ibn Nouaman, 3100, Kairouan, Tunisia. Electronic address:

Urogenital tuberculosis is a rare and severe disease since it causes serious consequences. Often, diagnosis may be delayed because of its multiple presentation forms and clinical features. Usually, the recognition is easy to hold, but in certain cases the presentation form can be misleading which can exclude the diagnosis. Read More

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November 2020

Diagnostic performance of EBUS-TBNA and its interrelation with PET-CT in patients with extra-thoracic malignancies.

Tuberk Toraks 2020 Sep;68(3):285-292

Department of Chest Diseases, Faculty of Medicine, Uludag University, Bursa, Turkey.

Introduction: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a well-established diagnostic tool for lung cancer, sarcoidosis, and suspected metastatic extra-thoracic malignancy (ETM). Patients with primary ETM often have hypermetabolic mediastinal/hilar lymph node enlargement in the PET-scan done for initial staging or post treatment followup. We aimed to determine the diagnostic performance of EBUS-TBNA and the relationship between PET-SUV values and diagnosis of malignancy metastasis in patients with ETM. Read More

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September 2020

Multimodality Imaging of Genitourinary Tuberculosis.

Curr Probl Diagn Radiol 2021 Nov-Dec;50(6):867-883. Epub 2020 Nov 15.

University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address:

Tuberculosis (TB) prevalence has increased over the past few decades, especially in the developing world. The genitourinary tract is the most common extra-pulmonary location of TB. Symptoms of genitourinary TB are often vague. Read More

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October 2021

[The features of the recurrence of urogenital tuberculosis].

Urologiia 2020 11(5):15-19

TB Research Institute of Ministry of Health of Russia, Novosibirsk, Russia.

Introduction: Tuberculosis is an infectious disease, which can result in self-cure, chronic process or relapse course.

Aim: To analyze the incidence of recurrence of urogenital tuberculosis and to identify the features of patients with recurrent disease.

Materials And Methods: Specially developed questionnaires on the structure of the incidence of extrapulmonary tuberculosis in the Siberian Federal District and the Far Eastern Federal District were analyzed. Read More

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November 2020

Length of hospital stay for TB varies with comorbidity and hospital location.

Int J Tuberc Lung Dis 2020 09;24(9):948-955

Lung Centre, Department of Pneumology and Sleep Medicine, Cantonal Hospital St Gallen, St Gallen, Tuberculosis Competence Centre, Swiss Lung Association, Berne, Switzerland.

Although most guidelines overwhelmingly recommend outpatient TB treatment, hospitalisations are common. We investigated the proportion of TB patients hospitalised and determined factors associated with length of stay (LOS) in Switzerland. Cases with TB as the primary diagnosis were retrieved from a nation-wide hospitalisation database and compared to TB notifications. Read More

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September 2020

Update on urogenital tuberculosis in Southern Tunisia: a review of a 26-year period.

Germs 2020 Sep 1;10(4):150-156. Epub 2020 Sep 1.

MD, Infectious Diseases Department and Extra-pulmonary Research Unity, Hedi Chaker University Hospital, University of Sfax, 3029, Tunisia.

Introduction: Tuberculosis affects commonly the lungs, but any other organs can be affected as well. Urogenital tuberculosis is usually misdiagnosed. In this perspective, we aimed to give an update on the epidemiological, clinical and evolutionary features of urogenital tuberculosis in Southern Tunisia. Read More

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September 2020

Male genital tract tuberculosis: A comprehensive review of imaging findings and differential diagnosis.

Abdom Radiol (NY) 2021 04 12;46(4):1677-1686. Epub 2020 Oct 12.

Department of Radiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Urogenital tuberculosis is the most common form of extrapulmonary tuberculosis. Genital organ involvement occurs as a continuum of urinary tract tuberculosis and often presents a diagnostic challenge due to the non-specific nature of the symptoms. Delay in diagnosis may lead to complications such as infertility and perineoscrotal sinuses. Read More

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An adolescent girl with obstructive uropathy requiring nephro-ureterectomy was subsequently diagnosed with renal tuberculosis: case report.

Paediatr Int Child Health 2021 May 29;41(2):154-157. Epub 2020 Sep 29.

Department of Pediatrics, Division of Pediatric Infectious Disease, Faculty of Medicine, Istanbul University, Istanbul, Turkey.

A 15-year-old girl was followed up for 2 years in a district hospital for management of vesicoureteral reflux and, subsequently, hydronephrosis of both kidneys and required bilateral ureteroneocystostomy. Despite surgery, there was continuous progression of the left hydronephrosis. Referral to a tertiary hospital because of continued sterile pyuria prompted investigation for tuberculosis (TB): she was diagnosed with bilateral pulmonary TB and urine culture confirmed . Read More

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Testicular tuberculosis: An uncommon complication after treatment of urothelial carcinoma.

Radiol Case Rep 2020 Nov 11;15(11):2285-2293. Epub 2020 Sep 11.

Morristown Medical Center, 100 Madison Avenue, Morristown, NJ 07960, USA.

Tuberculous epididymo-orchitis is an uncommon complication after intravesical bacilli Calmette-Guerin therapy for nonmuscle invasive bladder cancer. Spread of granulomatous disease through the genitourinary tract specifically to the testes occurs in 0.4% of treated patients. Read More

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November 2020

The best rules for antimicrobial stewardship in urogenital tract infections.

Curr Opin Urol 2020 11;30(6):838-844

Novosibirsk Research TB Institute, Novosibirsk, Russian Federation, Novosibirsk State Medical University Novosibirsk, Russian Federation.

Purpose Of Review: Urinary tract infections (UTIs) belong to the most common community-acquired and nosocomial infections, but therapy of UTIs is limited by resistance of pathogens and nonoptimal using of antibacterials. Narrative review of recent (2020-2018) literature dedicated to antimicrobial stewardship (AMS) in urological infections has been done.

Recent Findings: Analysis of recent 64 articles has shown following principles of AMS for UTIs: selecting the correct drug, correct dose, and shortest clinically effective duration of therapy whenever possible, is a base for optimal antimicrobial stewardship; symptomatic UTIs should be treated with antimicrobials to alleviate symptoms, and in the case of more serious infection, to prevent complications; in both symptomatic and asymptomatic infection, quantitative culture is the gold standard for diagnosis; we have to avoid prescriptions of antibiotics when possible; we have to follow European and National Guidelines; we must avoid prescription of fluoroquinolones as empiric therapy for UTIs by many reasons, one of these is urogenital tuberculosis; the choice of antibiotic for UTI should be based on local level of resistance of uropathogens. Read More

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November 2020