248,603 results match your criteria Tuberculosis Genitourinary Tract


The role of glutamine metabolism for host defense against Mycobacterium tuberculosis infection.

J Infect Dis 2018 Dec 12. Epub 2018 Dec 12.

Radboud university medical center, Department of Internal Medicine and Radboud Center of Infectious Diseases, Nijmegen, the Netherlands.

Background: Rewiring cellular metabolism is important for activation of immune cells during host defense against Mycobacterium tuberculosis. Glutamine has been implicated as an immunomodulatory nutrient, but its role in response to M. tuberculosis is unknown. Read More

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December 2018
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An elderly man with gastric cancer, Saint's triad and Heyde's syndrome.

Rev Gastroenterol Peru 2018 Jul-Sep;38(3):289-292

Armed Forces Hospital. Brasília-DF, Brazil.

This case study describes a 71-year-old man with signet-ring cell gastric adenocarcinoma and malignant sigmoidal polyp; and typical features of Saint's triad and Heyde syndrome. He had digestive bleeding, two types of hernia, diverticulosis, arterial hypertension, malignant polyp, and antecedent of smoking, lung tuberculosis, and surgical correction of aortic valve stenosis. There is a hypothetical inverse relationship between herniosis and development of malignancy; however, the patient herein described presented gastric and sigmoidal cancers. Read More

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December 2018

Importance of cerebrospinal fluid investigation during dengue infection in Brazilian Amazonia Region.

Mem Inst Oswaldo Cruz 2018 Dec 10;114:e180450. Epub 2018 Dec 10.

Universidade Federal do Estado do Rio de Janeiro/Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

BACKGROUND Amazon, the largest tropical forest of the world, has suffered from dengue outbreaks since 1998. Cerebrospinal fluid (CSF) of patients, from Amazonas state, suspected of central nervous system (CNS) viral infection was studied using molecular and immunological methods. OBJECTIVE To evaluate the importance of CSF investigation in patients with acute dengue virus (DENV) infection of CNS. Read More

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December 2018

Molecular Characterization and Drug Susceptibility of Isolated from Cattle in Xinjiang, China.

Chin Med J (Engl) 2018 Dec;131(24):3017-3019

National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.

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December 2018

Mycobacterium tuberculosis Rv1473 is a novel macrolides ABC Efflux Pump regulated by WhiB7.

Future Microbiol 2018 Dec 12. Epub 2018 Dec 12.

Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment & Bio-Resource of the Three Gorges Area, Key Laboratory of Eco-environments in Three Gorges Reservoir Region, Ministry of Education, School of Life Sciences, Southwest University, Beibei, Chongqing 400715, PR China.

Aim: To characterize a novel macrolide ATP binding cassette efflux pump encoding gene Rv1473 which might be involved in antibiotic resistance.

Methods: Mycobacterium smegmatis was used as a surrogate model for pathogenic mycobacteria, drug susceptibility assays and ethidium bromide accumulation assay were harnessed to verify drug resistance. The real-time quantitative PCR was used to evaluate the transcription levels of WhiB7 and Ms3140 upon exposure to macrolides. Read More

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December 2018

Decontamination of Biobank Facilities.

Methods Mol Biol 2019 ;1897:227-241

Biospecimen Laboratory, Loma Linda University Cancer Center, Loma Linda, CA, USA.

Biobanks are facilities that collect, process, store, annotate, and distribute high-quality and well-maintained human biological specimens (biospecimens) for investigational use. They play a crucial role in biomarker research and contribute to our understanding about preventing, diagnosing, and treating diseases. Majority of the biospecimens are from patients volunteering to provide biospecimens that would normally be discarded after diagnostic or therapeutic procedures. Read More

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January 2019

Tuberculosis elimination in Oman: winning the war on the disease.

ERJ Open Res 2018 Oct 7;4(4). Epub 2018 Dec 7.

Office of Health Affairs, Ministry of Health, Muscat, Oman.

In 2014, the World Health Assembly adopted the new End TB Strategy that targets ending tuberculosis (TB) by 2035. This article describes the progress made to eliminate TB in Oman. Data from officials and other sources provided the information to assess the situation in Oman. Read More

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October 2018

Models for Predicting Time to Sputum Conversion Among Multi-Drug Resistant Tuberculosis Patients in Lagos, South-West Nigeria.

Front Public Health 2018 27;6:347. Epub 2018 Nov 27.

Department of Research and Innovation, University of Lagos, Lagos, Nigeria.

Multi-drug resistant tuberculosis (MDR-TB) develops due to problems such as irregular drug supply, poor drug quality, inappropriate prescription, and poor adherence to treatment. These factors allow the development and subsequent transmission of resistant strains of the pathogen. However, due to the chronic nature of MDR-TB, cure models allow us to investigate the covariates that are associated with the long-term effects of time-to-sputum conversion among multi-drug resistant (MDR-TB) tuberculosis individuals. Read More

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November 2018

Virulence of Clinical Isolates Is Associated With Sputum Pre-treatment Bacterial Load, Lineage, Survival in Macrophages, and Cytokine Response.

Front Cell Infect Microbiol 2018 27;8:417. Epub 2018 Nov 27.

Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.

It is uncertain whether differences in ( virulence defined influence clinical tuberculosis pathogenesis, transmission, and mortality. We primarily used a macrophage lysis model to characterize the virulence of isolates collected from 153 Vietnamese adults with pulmonary tuberculosis. The virulence phenotypes were then investigated for their relationship with sputum bacterial load, bacterial lineages, bacterial growth, and cytokine responses in macrophages. Read More

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November 2018

Significant Neutrophilic Emperipolesis in Squamous Cell Carcinoma.

Case Rep Oncol Med 2018 13;2018:1301562. Epub 2018 Nov 13.

Department of Ear, Nose, and Throat Disease, Bakırköy Sadi Konuk Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.

A 53-year-old man was admitted for tooth mobility. A mass was identified at the tooth base by CT. Histopathology of the excisional biopsy revealed a moderately differentiated squamous cell carcinoma. Read More

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November 2018

Tuberculosis of the Thyroid Gland Presented as a Rapid Enlargement of a Preexisting Goiter.

Case Rep Endocrinol 2018 12;2018:4369531. Epub 2018 Nov 12.

Department of Endocrinology, La Rabta hospital, Faculty of Medicine, University of Tunis El Manar, Tunis, Tunisia.

Thyroid involvement with tuberculosis is an uncommon condition even in endemic countries. As its clinical presentation is not specific, diagnosis is often difficult and requires histopathological confirmation. Herein we report an observation of secondary tuberculosis of the thyroid gland in a woman with a type 2 diabetes mellitus and a primary hypothyroidism. Read More

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November 2018

Diagnostic Errors in Tuberculous Patients: A Multicenter Study from a Developing Country.

J Environ Public Health 2018 13;2018:1975931. Epub 2018 Nov 13.

Department of Statistics, Faculty of Mathematical Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.

Although there is still much to learn about the types of errors committed in health care and why they occur, enough is known today to recognize that a serious concern exists for patients. Tuberculosis (TB) is an infectious disease that is frequently subject to diagnostic errors. Missed or delayed diagnosis of TB can affect patients and community adversely. Read More

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November 2018

Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa.

Front Genet 2018 27;9:575. Epub 2018 Nov 27.

West African Centre for Cell Biology of Infectious Pathogens, University of Ghana, Accra, Ghana.

Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as and parasites such as . This ranges from investigations of disease outbreaks and pathogenesis, host and pathogen genomic variation, and host immune evasion mechanisms to identification of potential diagnostic markers and vaccine targets. High throughput genomics data generated from pathogens and animal models can be combined with host genomics and patients' health records to give advice on treatment options as well as potential drug and vaccine interactions. Read More

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November 2018

Induction of Lipid-Specific T Cell Responses by Pulmonary Delivery of Mycolic Acid-Loaded Polymeric Micellar Nanocarriers.

Front Immunol 2018 27;9:2709. Epub 2018 Nov 27.

Interdisciplinary Biological Sciences Program, Northwestern University, Evanston, IL, United States.

Mycolic acid (MA), a major lipid component of (Mtb) cell wall, can be presented by the non-polymorphic antigen presenting molecule CD1b to T cells isolated from Mtb-infected individuals. These MA-specific CD1b-restricted T cells are cytotoxic, produce Th1 cytokines, and form memory populations, suggesting that MA can be explored as a potential subunit vaccine candidate for TB. However, the controlled elicitation of MA-specific T cell responses has been challenging due to difficulties in the targeted delivery of lipid antigens and a lack of suitable animal models. Read More

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November 2018
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A New Phylogenetic Framework for the Animal-Adapted Complex.

Front Microbiol 2018 27;9:2820. Epub 2018 Nov 27.

Swiss Tropical and Public Health Institute, Basel, Switzerland.

Tuberculosis (TB) affects humans and other animals and is caused by bacteria from the complex (MTBC). Previous studies have shown that there are at least nine members of the MTBC infecting animals other than humans; these have also been referred to as ecotypes. However, the ecology and the evolution of these animal-adapted MTBC ecotypes are poorly understood. Read More

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November 2018

Primary Appendicular Malignancy Presenting as Abdominal Wall Abscess with Secondary Tuberculosis Infection: an Interesting Case Report.

Indian J Surg Oncol 2018 Dec 7;9(4):613-617. Epub 2018 Aug 7.

Parvarish Nursing Home, Andheri, Mumbai, Maharashtra India.

Cancers of the appendix are rare. Most of them are found accidentally on appendectomies performed for appendicitis. When reviewed, majority of the tumors were carcinoid, adenoma, and lymphoma. Read More

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December 2018

Multidrug-resistant tuberculosis (MDR-TB) strain infection in macaques results in high bacilli burdens in airways, driving broad innate/adaptive immune responses.

Emerg Microbes Infect 2018 Dec 12;7(1):207. Epub 2018 Dec 12.

Clinic and Research Center of Tuberculosis, Shanghai Key Laboratory of Tuberculosis, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.

Tuberculosis (TB) has become the most deadly infectious diseases due to epidemics of HIV/AIDS and multidrug-resistant/extensively drug-resistant TB (MDR-/XDR-TB). Although person-to-person transmission contributes to MDR-TB, it remains unknown whether infection with MDR strains resembles infection with drug-sensitive (DS) TB strains, manipulating limited or broad immune responses. To address these questions, macaques were infected with MDR strain V791 and a drug-sensitive Erdman strain of TB. Read More

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December 2018

ORBIT: a New Paradigm for Genetic Engineering of Mycobacterial Chromosomes.

MBio 2018 Dec 11;9(6). Epub 2018 Dec 11.

Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA

Two efficient recombination systems were combined to produce a versatile method for chromosomal engineering that obviates the need to prepare double-stranded DNA (dsDNA) recombination substrates. A synthetic "targeting oligonucleotide" is incorporated into the chromosome via homologous recombination mediated by the phage Che9c RecT annealase. This oligonucleotide contains a site-specific recombination site for the directional Bxb1 integrase (Int), which allows the simultaneous integration of a "payload plasmid" that contains a cognate recombination site and a selectable marker. Read More

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December 2018
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The A-type domain in NfuA is required for regenerating the auxiliary [4Fe-4S] cluster in lipoyl synthase.

J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.

Chemistry, Pennsylvania State University, United States.

The lipoyl cofactor plays an integral role in several essential biological processes. The last step in its biosynthetic pathway, the attachment of two sulfur atoms at C6 and C8 of an -octanoyl-lysyl chain, is catalyzed by lipoyl synthase (LipA), a member of the radical SAM superfamily. In addition to the [4Fe-4S] cluster common to all radical SAM enzymes, LipA contains a second [4Fe-4S] auxiliary cluster, which is sacrificed during catalysis to supply the requisite sulfur atoms, rendering the protein inactive for further turnovers. Read More

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December 2018

Epithelioid cell granuloma with caseating necrosis possibly caused by periapical periodontitis: a case report.

J Med Case Rep 2018 Dec 11;12(1):365. Epub 2018 Dec 11.

Department of Oral and Maxillofacial Surgery, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan.

Background: Epithelioid cell granuloma with caseating necrosis is a typical pathological finding in tuberculosis. While specific inflammation, including that related to tuberculosis, can induce caseating granuloma formation, there have been very few reports on the induction of caseating granuloma by non-specific inflammation. Chronic periapical periodontitis is usually related to bacterial biofilm formation as well as fungal or viral infection in the periapical lesion. Read More

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December 2018

Use of predicted vital status to improve survival analysis of multidrug-resistant tuberculosis cohorts.

BMC Med Res Methodol 2018 Dec 11;18(1):166. Epub 2018 Dec 11.

Department of Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, MA, 02115, USA.

Background: Multidrug-resistant tuberculosis (MDR-TB) cohorts often lack long-term survival data, and are summarized instead by initial treatment outcomes. When using Cox proportional hazards models to analyze these cohorts, this leads to censoring subjects at the time of the initial treatment outcome, instead of them providing full survival data. This may violate the non-informative censoring assumption of the model and may produce biased effect estimates. Read More

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December 2018

Nicotine Modulates the Release of Inflammatory Cytokines and Expression of TLR2, TLR4 of Cord Blood Mononuclear Cells.

Iran J Allergy Asthma Immunol 2018 Aug 12;17(4):372-378. Epub 2018 Aug 12.

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran AND Department of Immunology, Faculty of Medicine, Shahid Beheshti University of  Medical Sciences, Tehran, Iran.

The underlying mechanisms of how nicotine affects cord umbilical cells remain largely elusive. Nicotine rapidly crosses the blood-brain barrier (10 to 20 s) and binds to nicotinic acetylcholine receptors (nAChRs). Nicotine considered as a major compound found in cigarette smoke and the mechanism of nicotine action in immune response is not well understood. Read More

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Efficacy of tolvaptan in a patient with right-sided heart failure and renal dysfunction refractory to diuretic therapy.

J Cardiol Cases 2014 Jun 25;9(6):226-229. Epub 2014 Mar 25.

Department of Cardiology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.

The use of loop diuretics has been shown to deteriorate renal dysfunction and is associated with a poor prognosis in patients with heart failure (HF). Tolvaptan, a vasopressin V2-receptor antagonist, has been reported to be effective in treating HF due to its potent effects of water diuresis and is expected to improve fluid retention without adversely affecting renal function. The present case is a 77-year-old man with pulmonary hypertension associated with chronic pulmonary artery thrombosis and old pulmonary tuberculosis who developed worsening right-sided HF with marked fluid retention and renal dysfunction. Read More

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Metabolite changes in blood predict the onset of tuberculosis.

Nat Commun 2018 12 6;9(1):5208. Epub 2018 Dec 6.

Max Planck Institute for Infection Biology, 10117, Berlin, Germany.

New biomarkers of tuberculosis (TB) risk and disease are critical for the urgently needed control of the ongoing TB pandemic. In a prospective multisite study across Subsaharan Africa, we analyzed metabolic profiles in serum and plasma from HIV-negative, TB-exposed individuals who either progressed to TB 3-24 months post-exposure (progressors) or remained healthy (controls). We generated a trans-African metabolic biosignature for TB, which identifies future progressors both on blinded test samples and in external data sets and shows a performance of 69% sensitivity at 75% specificity in samples within 5 months of diagnosis. Read More

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December 2018

Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection.

J Ethnopharmacol 2018 Dec 8. Epub 2018 Dec 8.

Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi, India. Electronic address:

Ethnopharmacological Relevance: The emergence of drug-resistant Mycobacterium tuberculosis (M.tb) strains has severely hampered global efforts towards tuberculosis (TB) eradication. The internationally accepted therapy "Directly Observed Treatment Short-course (DOTS)" is lengthy, and incorporates risks for the generation of drug-resistant M. Read More

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December 2018
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Structures and activities of widely conserved small prokaryotic Aminopeptidases P clarify classification of M24B peptidases.

Proteins 2018 Dec 11. Epub 2018 Dec 11.

High Pressure and Synchrotron Radiation Physics Division, Bhabha Atomic Research Centre, Mumbai, India.

The proline-specific M24B peptidases that cleave Xaa-Pro iminopeptide bond in dipeptides are called prolidases while those that preferentially cleave this bond at the N-termini of longer peptides are called aminopeptidases-P. Escherichia coli and other bacteria have small aminopeptidases-P (36-39 kDa) which are considerably diverged from the canonical aminopeptidase-P of E. coli (50 kDa). Read More

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December 2018

Reducing Lead and Silica Dust Exposures in Small-Scale Mining in Northern Nigeria.

Ann Work Expo Health 2018 Dec 8. Epub 2018 Dec 8.

Occupational Knowledge International, San Francisco, CA , USA.

Purpose: An ongoing health crisis across a large area of Northern Nigeria has resulted in hundreds of deaths and thousands of cases of lead poisoning from artisanal small-scale gold mining. Occupational Knowledge International (OK International) and Doctors Without Borders/Médecins Sans Frontières (MSF) have formed a partnership to conduct a pilot project to introduce safer mining practices in selected communities. The primary objective was to reduce lead exposures among artisanal small-scale miners and minimize take home exposures by reducing dust contamination on clothing and body surfaces. Read More

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December 2018
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Effectiveness and Safety of Reference Infliximab and Biosimilar in Crohn Disease: A French Equivalence Study.

Ann Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Caisse Nationale de l'Assurance Maladie, Paris, and Hôpital Bicêtre, Le Kremlin-Bicêtre, France (A.M., J.C.).

Background: CT-P13 is a biosimilar of the reference product (RP) infliximab, with demonstrated efficacy and safety for some inflammatory arthritides. It was approved for the treatment of Crohn disease (CD) on that basis, without specific studies examining its effects in CD.

Objective: To compare the effectiveness and safety of CT-P13 and RP in infliximab-naive patients with CD. Read More

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December 2018

An interferon gamma release assay specific for Histoplasma capsulatum to detect asymptomatic infected individuals: A proof of concept study.

Med Mycol 2018 Dec 11. Epub 2018 Dec 11.

Grupo de Micología Médica y Experimental, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia.

Histoplasmosis is the most common endemic mycosis in the Americas. Currently, there is no laboratory test capable to detect subclinical or latent infections by Histoplasma capsulatum (Hc), which might develop as severe infections in immunocompromised individuals. For the first time to our knowledge, we explore the suitability of an interferon gamma release assay (IGRA) to detect latent Hc infection in asymptomatic individuals. Read More

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December 2018
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The Expression of lncRNA NEAT1 in Human Tuberculosis and Its Antituberculosis Effect.

Biomed Res Int 2018 11;2018:9529072. Epub 2018 Nov 11.

Intensive Care Unit, The First Affiliated Hospital of Nanchang University, Nanchang, 330006 Jiangxi, China.

Increasing evidence suggests that lncRNA is important in innate immune responses. Recent study has demonstrated that lncRNA NEAT1 (which has two subtypes: NEAT1_1 and NEAT1_2) nuclear-enriched abundant transcript 1 (NEAT1) is essential in immune regulation, but the expression and clinical significance in tuberculosis are still unclear. In this work, we aimed to discuss the expression and clinical significance of NEAT1 in tuberculosis patients. Read More

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November 2018
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Line-probe assay and molecular typing reveal a potential drug resistant clone of in Ethiopia.

Trop Dis Travel Med Vaccines 2018 4;4:15. Epub 2018 Dec 4.

1Armauer Hansen Research Institute, Jima Road, Addis Ababa, Ethiopia.

Background: Antimicrobial resistance is a global concern of increasing significance. Multidrug resistant tuberculosis (MDR-TB) is spreading worldwide. It is important to monitor trends of antimycobacterial resistance. Read More

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December 2018
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The bovine tuberculosis cluster in north County Sligo during 2014-16.

Ir Vet J 2018 28;71:24. Epub 2018 Nov 28.

2Centre for Veterinary Epidemiology and Risk Analysis, UCD School of Veterinary Medicine, University College Dublin, Belfield, Dublin, D04 W6F6 Ireland.

Background: Bovine tuberculosis (bTB, caused by infection with ) is endemic in the Irish cattle population, and the subject of a national eradication programme since the late 1950s. During 2014, a substantial area-level bTB outbreak developing in north County Sligo, necessitating the need for an enhanced response. This paper describes this outbreak, the response that was undertaken and some lessons learned. Read More

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November 2018

Lipocalin-2 Functions as Inhibitor of Innate Resistance to .

Front Immunol 2018 26;9:2717. Epub 2018 Nov 26.

Granulocyte Research Laboratory, Rigshospitalet, Copenhagen, Denmark.

Lipocalin-2 is a constituent of the neutrophil secondary granules and is expressed by macrophages and epithelium in response to inflammation. Lipocalin-2 acts in a bacteriostatic fashion by binding iron-loaded siderophores required for bacterial growth. (M. Read More

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November 2018
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The Mediating Effects of Stigma on Depressive Symptoms in Patients With Tuberculosis: A Structural Equation Modeling Approach.

Front Psychiatry 2018 26;9:618. Epub 2018 Nov 26.

School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

To date, the complex interrelationships between family function, doctor-patient communication, knowledge about tuberculosis (TB), stigma, and depressive symptoms among patients with TB are insufficiently understood. We explored the interrelationships between family function, doctor-patient communication, knowledge about TB, TB-related stigma, and depressive symptoms and examined whether TB-related stigma played a mediating role. A cross-sectional survey was conducted between October 1, 2013 and March 31, 2014 in Hubei province, central China. Read More

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November 2018

Long-lasting cutaneous tuberculosis owing to masquerading as sarcoidosis.

JAAD Case Rep 2019 Jan 27;5(1):1-4. Epub 2018 Nov 27.

Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.

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January 2019

Mycobacterium tuberculosis Infection in the Setting of Interstitial Lung Disease: Coincidence or Bad Luck?

Cureus 2018 Oct 1;10(10):e3391. Epub 2018 Oct 1.

Pulmonology, New York Presbyterian Hospital Queens, New York, USA.

Mycobacterium tuberculosis (MTB) infection is the ninth leading cause of death worldwide, with many individuals with undiagnosed active or latent disease. The presence of parenchymal lung disease, such as interstitial lung disease (ILD), has been suggested to increase the risk of pulmonary tuberculosis (TB). In the clinical setting of ILD, the diagnosis of an underlying MTB infection may be challenging due to the interstitial process and underlying fibrosis, which may mask the infection. Read More

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October 2018
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MtrA Response Regulator Controls Cell Division and Cell Wall Metabolism and Affects Susceptibility of Mycobacteria to the First Line Antituberculosis Drugs.

Front Microbiol 2018 23;9:2839. Epub 2018 Nov 23.

Biomedical Research, The University of Texas Health Science Center, Tyler, TX, United States.

The biological processes regulated by the essential response regulator MtrA and the growth conditions promoting its activation in , a slow grower and pathogen, are largely unknown. Here, using a gain-of-function mutant, MtrA, which functions in the absence of the cognate MtrB sensor kinase, we show that the MtrA regulon includes several genes involved in the processes of cell division and cell wall metabolism. The expression of selected MtrA targets and intracellular MtrA levels were compromised under replication arrest induced by genetic manipulation and under stress conditions caused by toxic radicals. Read More

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November 2018

Severe neutropenia in a breastfed infant: a case report and discussion of the differential diagnosis.

Int Med Case Rep J 2018 15;11:333-337. Epub 2018 Nov 15.

Department of Pediatrics, Queen Paola Children's Hospital, Antwerp, Belgium,

Neonatal neutropenia is regularly seen with variable etiology. We describe a breastfed infant with maternal medication use as a probable cause of neonatal neutropenia. An 8 days old exclusively breastfed female infant of Arab-Berber descent was referred to our hospital because of an infection of the umbilicus. Read More

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November 2018

Vitamin D3 as adjunctive therapy in the treatment of depression in tuberculosis patients: a short-term pilot randomized double-blind controlled study.

Neuropsychiatr Dis Treat 2018 14;14:3103-3109. Epub 2018 Nov 14.

Department of Tuberculosis Control, Ningbo Municipal Center for Disease Control & Prevention, Ningbo, Zhejiang, People's Republic of China,

Objective: We aimed to evaluate whether high-dose cholecalciferol has beneficial effects on depression in pulmonary tuberculosis (PTB) patients.

Methods: This pilot, randomized, and double-blind trial enrolled 123 recurrent PTB patients (aged ≥18 years) meeting criteria of major depressive disorder from four hospitals in Southeast China. Patients were randomly assigned to 8-week oral treatment with 100,000 IU/week cholecalciferol (Vit D group) or a matching placebo (control group). Read More

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November 2018

Mycobacterial glycolipid Di-O-acyl trehalose promotes a tolerogenic profile in dendritic cells.

PLoS One 2018 10;13(12):e0207202. Epub 2018 Dec 10.

Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, México City, México.

Due to prolonged coevolution with the human being, Mycobacterium tuberculosis has acquired a sophisticated capacity to evade host immunity and persist in a latent state in the infected individual. As part of this evolutive process, mycobacteria have developed a highly complex cell wall that acts as a protective barrier. Herein we studied the effects of Di-O-acyl trehalose, a cell-wall glycolipid of virulent mycobacteria on murine bone marrow-derived dendritic cells. Read More

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December 2018

Nested Polymerase Chain Reaction and Cutaneous Tuberculosis.

Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, Mexico City, México.

The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Read More

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November 2018

Early and late virologic failure following virologic suppression in HIV-infected Asian children and adolescents.

J Acquir Immune Defic Syndr 2018 Nov 20. Epub 2018 Nov 20.

Clinical and Research Center of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, China.

Background: Virologic failure is a major threat to maintaining effective combination antiretroviral therapy, especially for children in need of lifelong treatment. With efforts to expand access to HIV viral load testing, our understanding of pediatric virologic failure is evolving.

Setting: An Asian cohort in16 pediatric HIV services across six countries. Read More

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November 2018

Cognitive Impairment in Zambians With HIV Infection and Pulmonary Tuberculosis.

J Acquir Immune Defic Syndr 2019 Jan;80(1):110-117

Department of Psychiatry, University of California, San Diego, CA.

Background: HIV infection may result in neurocognitive deficits, but the effects of pulmonary tuberculosis (TB+), a common comorbid condition in HIV infection, on cognition in HIV infections are unknown. Accordingly, we examined the effects of TB+, on neurocognitive functioning in HIV-infected (HIV+) Zambian adults.

Setting: All participants were drawn from HIV clinics in and around Lusaka, the capital of Zambia. Read More

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January 2019

How to kill dormant .

Int J Mycobacteriol 2018 Oct-Dec;7(4):399-400

A.N. Bach Institute of Biochemistry, Federal Research Centre "Fundamentals of Biotechnology" of the Russian Academy of Sciences, Moscow, Russia.

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December 2018

Isolated splenic tuberculosis presenting as an unusual splenic mass.

Int J Mycobacteriol 2018 Oct-Dec;7(4):397-398

Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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December 2018

Cryptococcal antigenemia screening among human immunodeficiency virus-infected cases with tuberculosis: Chance and cost effectiveness.

Int J Mycobacteriol 2018 Oct-Dec;7(4):395-396

Department of Community Medicine, Dr. DY Patil University, Pune, Maharashtra, India.

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December 2018

Unrecognized and delayed to diagnose of adolescence tuberculosis case in a boarding school in West Java, Indonesia.

Int J Mycobacteriol 2018 Oct-Dec;7(4):387-389

Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia.

Adolescent is a high-risk population for developing tuberculosis (TB) disease, unfortunately adolescence TB remains to be neglected. Clinical manifestations of TB are usually chronic and nonspecific that could be mimicking other disease. Unrecognized TB disease will lead to misdiagnosis, delayed, and inappropriate management. Read More

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December 2018

Polymorphisms of NAT2, CYP2E1, GST, and HLA related to drug-induced liver injury in indonesian tuberculosis patients.

Int J Mycobacteriol 2018 Oct-Dec;7(4):380-386

Unit of PharmacoTherapy, Epidemiology and Economics, University of Groningen, Groningen Research Institute of Pharmacy, Groningen, The Netherlands.

Background: Gene polymorphisms have been associated with drug-induced liver injury (DILI). This study aimed to elucidate the association between polymorphisms of NAT2, CYP2E1, GSTT1, GSTM1, and HLA genes with isoniazid plasma concentration and DILI.

Methods: This study was a prospective cohort study recruiting adult newly diagnosed tuberculosis (TB) patients who met the inclusion criteria from the Public Health Centers in Yogyakarta and Lampung. Read More

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December 2018

Infection of multiple strains among tuberculosis/human immunodeficiency virus co-infected patients: A molecular study in Myanmar.

Int J Mycobacteriol 2018 Oct-Dec;7(4):375-379

Department of Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.

Background: Appearance of Mycobacterium tuberculosis (MTB) in the sputum of a tuberculosis (TB)/human immunodeficiency virus (HIV) co-infected patient under treatment may indicate either failure or new infection. This study aims to evaluate whether TB treatment failure among TB/HIV co-infected patients is a real failure.

Methods: A prospective cohort study was conducted among 566 TB/HIV co-infected patients who started TB treatment in 12 townships in the upper Myanmar. Read More

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December 2018