5,159 results match your criteria Tuberculosis Gastrointestinal

Currarino syndrome as an incidental radiologic finding in a patient with acute flank pain: A case report.

Radiol Case Rep 2022 Sep 17;17(9):2936-2939. Epub 2022 Jun 17.

Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Currarino syndrome is an autosomal dominant hereditary disease defined as a triad of anorectal abnormality, sacral dysgenesis, and a presacral mass, primarily an anterior sacral meningocele. It is often seen in children and considered rare in adults. It is mostly found as an incidental finding. Read More

View Article and Full-Text PDF
September 2022

Gastrointestinal tuberculosis presenting as acute abdomen: a case report.

J Surg Case Rep 2022 Jun 21;2022(6):rjac305. Epub 2022 Jun 21.

Department of General Surgery, Luigi Sacco University Hospital, Milan, Italy.

Intestinal tuberculosis (ITB) represents an important diagnostic challenge in the clinical setting, as it generally can occur as a chronic condition often mimicking other diseases such as Crohn's disease (CD), and can present itself with acute onset, which can be life-threatening. A 29-years-old Chinese woman coming to ER with abdominal pain, fever and weight loss. Computed tomography and colonoscopy images were not diagnostic. Read More

View Article and Full-Text PDF

A short cut to gut: gastrocolic fistula secondary to gastrointestinal tuberculosis (TB).

ANZ J Surg 2022 Jun 27. Epub 2022 Jun 27.

Department of Colorectal Surgery, The Northern Hospital, Melbourne, Victoria, Australia.

View Article and Full-Text PDF

Frequency and Management of Adverse Drug Reactions Among Drug-Resistant Tuberculosis Patients: Analysis From a Prospective Study.

Front Pharmacol 2022 2;13:883483. Epub 2022 Jun 2.

Discipline of Clinical Pharmacy, School of Pharmaceutical Sciences, Universiti Sains Malaysia, George Town, Malaysia.

Drug-resistant tuberculosis (DR-TB) management is often linked with a higher rate of adverse drug reactions (ADRs) needing effective and timely management of these ADRs, which, if left untreated, may result in a higher rate of loss to follow-up of drug-resistant patients. The study was aimed at prospectively identifying the nature, frequency, suspected drugs, and management approaches for ADRs along with risk factors of ADRs occurrence among DR-TB patients at Nishtar Medical University, Hospital, Multan, Pakistan. The prospective study included all the DR-TB patients enrolled for treatment from January 2016 to May 2017 at the study site Patients were evaluated for the treatment-induced ADRs as per standard criteria of the National Tuberculosis Program, Pakistan. Read More

View Article and Full-Text PDF

Crohn's disease versus gastrointestinal tuberculosis: A diagnostic dilemma.

J Paediatr Child Health 2022 Jun 23. Epub 2022 Jun 23.

Department of Paediatrics, Royal Hobart Hospital, Hobart, Tasmania, Australia.

View Article and Full-Text PDF

Case Report: Protein-Losing Enteropathy in Association With Tuberculosis-Related Constrictive Pericarditis.

Front Pediatr 2022 30;10:875032. Epub 2022 May 30.

Department of Nephrology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Protein-losing enteropathy (PLE) is a clinical disorder in which an excessive amount of serum protein is lost into the gastrointestinal tract, resulting in hypoproteinemia and malnutrition. PLE is associated with a wide range of gastrointestinal disorders and the rare complication of constrictive pericarditis. We report a case in which pericardiectomy achieved marked improvement of extremely severe hypoalbuminemia caused by PLE associated with tuberculosis-related constrictive pericarditis. Read More

View Article and Full-Text PDF

Perianal ulcerative tuberculosis: A case report.

J Pak Med Assoc 2022 May;72(5):978-980

Department of Colorectal Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Zhejiang, China.

Perianal tuberculosis (TB) is an extremely rare form of mycobacterial infection, in which the anal mucocutaneous junction becomes infected by autoinoculation from an active draining gastrointestinal tract infection. The case of a 73-year-old immunocompetent male patient, who came in with a refractory perianal ulcer is presented. The patient had no history of TB and his lab tests for TB were all negative. Read More

View Article and Full-Text PDF

Treatment Outcomes Among Pregnant Patients With Multidrug-Resistant Tuberculosis: A Systematic Review and Meta-analysis.

JAMA Netw Open 2022 Jun 1;5(6):e2216527. Epub 2022 Jun 1.

Telethon Kids Institute, Nedlands, Western Australia, Australia.

Importance: The management of multidrug-resistant tuberculosis (MDR-TB) during pregnancy is challenging, yet no systematic synthesis of evidence has accurately measured treatment outcomes.

Objective: To systematically synthesize treatment outcomes and adverse events among pregnant patients with MDR-TB.

Data Sources: PubMed, Scopus, Web of Science, and ProQuest were searched from the inception of each database through August 31, 2021. Read More

View Article and Full-Text PDF

The diagnostic challenges in a child with intestinal tuberculosis.

Rom J Morphol Embryol 2021 Oct-Dec;62(4):1057-1061

3rd Pediatrics Department, Grigore Alexandrescu Emergency Children's Hospital, Bucharest, Romania;

Introduction: Romania is one of the European countries with a significant burden of tuberculosis (TB). Although pulmonary TB is still highly prevalent, intestinal TB is very rare and remains a diagnosis of exclusion, especially in children. The authors aimed to raise the awareness on this pathology by discussing the challenges faced in the management of one difficult case. Read More

View Article and Full-Text PDF

Furmonertinib (AST2818) versus gefitinib as first-line therapy for Chinese patients with locally advanced or metastatic EGFR mutation-positive non-small-cell lung cancer (FURLONG): a multicentre, double-blind, randomised phase 3 study.

Lancet Respir Med 2022 Jun 2. Epub 2022 Jun 2.

Shanghai Allist Pharmaceuticals, Shanghai, China.

Background: Furmonertinib (AST2818) is an irreversible, selective, third-generation EGFR tyrosine-kinase inhibitor. We aimed to investigate the efficacy and safety of furmonertinib versus the first-generation EGFR tyrosine-kinase inhibitor gefitinib as first-line treatment in patients with EGFR mutation-positive locally advanced or metastatic non-small-cell lung cancer (NSCLC).

Methods: The FURLONG study is a multicentre, double-blind, randomised, phase 3 study done in 55 hospitals across mainland China. Read More

View Article and Full-Text PDF

Enteropathogen spectrum and effect on antimycobacterial pharmacokinetics among children with tuberculosis in rural Tanzania: a prospective cohort study.

Lancet Microbe 2022 Jun 7;3(6):e408-e416. Epub 2022 Apr 7.

Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA. Electronic address:

Background: Enteropathy is prevalent in tuberculosis-endemic areas, and it has been shown to impair intestinal absorptive function; therefore, enteropathogen burden might negatively affect antimycobacterial pharmacokinetics, particularly among malnourished children. We sought to quantify enteropathogen burden among children initiating tuberculosis treatment in rural Tanzania and determine the effect of enteropathogen burden on serum antimycobacterial pharmacokinetics.

Methods: We performed a prospective cohort study at one site in rural Tanzania as an exploratory substudy of a large multicountry cohort study. Read More

View Article and Full-Text PDF

Assessment of Adverse Drug Events, Their Risk Factors, and Management Among Patients Treated for Multidrug-Resistant TB: A Prospective Cohort Study From Pakistan.

Front Pharmacol 2022 17;13:876955. Epub 2022 May 17.

Department of Pharmacy Administration and Clinical Pharmacy, Xi'an Jiaotong University, Xi'an, China.

Multidrug-resistant tuberculosis (MDR-TB) is a growing public health problem. Treatment regimens used against MDR-TB are costly, prolonged, and associated with more side effects as compared with the drug-susceptible tuberculosis. This study was framed to determine the incidence of adverse drug events, risk factors, and their management in MDR-TB patients. Read More

View Article and Full-Text PDF

Stool testing for pulmonary TB diagnosis in adults.

Int J Tuberc Lung Dis 2022 Jun;26(6):516-523

Department of Infectious Diseases, Aarhus University Hospital, Aarhus University, Aarhus, Denmark, Department of Public Health, Center for Global Health (GloHAU), Aarhus University, Aarhus, Denmark.

is acid-fast and able to survive in the gastrointestinal tract. Thus, bacteria can be found in stool if sputum is swallowed. In this study, the accuracy of different diagnostic stool methods (microscopy, polymerase chain reaction PCR and culture) among adults with pulmonary TB (PTB) were assessed and compared with sputum culture. Read More

View Article and Full-Text PDF

Esophageal brucellosis? Straight to the goat.

Int J Infect Dis 2022 May 28;122:276-278. Epub 2022 May 28.

Infectious Diseases Unit, Raymond Poincaré Teaching Hospital, AP-HP, Versailles Saint-Quentin University, Garches, France; UMR 1173, Université Paris Saclay, Montigny le Bretonneux, France. Electronic address:

We report the case of a 58-year-old immunocompetent man from Algeria, who presented to the hospital with fever and hepatic cytolysis. Abdominal computed tomography scan showed a homogeneous splenomegaly and a hypodense 12-mm mass on the posterior wall of the esophagus. After ruling out tuberculosis, the patient was diagnosed with brucellosis. Read More

View Article and Full-Text PDF

The Microbiome as Part of the Contemporary View of Tuberculosis Disease.

Pathogens 2022 May 16;11(5). Epub 2022 May 16.

Coordinación de Infectología y Microbiología, Instituto Nacional de Enfermedades Respiratorias (INER), Mexico City 14080, Mexico.

The study of the microbiome has changed our overall perspective on health and disease. Although studies of the lung microbiome have lagged behind those on the gastrointestinal microbiome, there is now evidence that the lung microbiome is a rich, dynamic ecosystem. Tuberculosis is one of the oldest human diseases, it is primarily a respiratory infectious disease caused by strains from the Complex. Read More

View Article and Full-Text PDF

Concurrent ascending colon adenocarcinoma and ileocecal tuberculosis: A case report.

Medicine (Baltimore) 2022 May 27;101(21):e29430. Epub 2022 May 27.

Department of Surgery, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Rationale: Few cases have been reported of the coexistence of tuberculosis and adenocarcinoma of the large bowel. We report a rare case of concurrent ascending colon adenocarcinoma and ileocecal tuberculosis, which were nearly indistinguishable from one another.

Patient Concerns: A 59-year-old man visited our clinic with dizziness and anorexia. Read More

View Article and Full-Text PDF

[Upper gastrointestinal bleeding due to tuberculous mesenteric lymphadenitis that fistulizes the gastric wall].

Rev Gastroenterol Peru 2021 Oct-Dec;41(4):271-274

Servicio de Gastroenterología, Hospital Nacional Arzobispo Loayza. Lima, Perú.

Tuberculous lymphadenitis is the most common entity of abdominal tuberculosis, which occurs due to reactivation of a latent focus. Its diagnosis requires a high degree of suspicion, for which it requires endoscopic, radiological, and histopathological studies. In the evaluation of lymphadenopathies, endoscopic ultrasound-guided aspiration puncture plays an important role. Read More

View Article and Full-Text PDF

Intestinal Tuberculosis Presenting with Gastrointestinal Bleeding in Patient on Warfarin Therapy.

Case Rep Gastrointest Med 2022 14;2022:9277789. Epub 2022 May 14.

Aga Khan University Hospital Nairobi, 4th Floor East Tower Block, Third Avenue Parklands, P.O. Box 30270, Nairobi 00100, GPO, Kenya.

Background: Intestinal tuberculosis (ITB) constitutes less than 5% of overall cases of extrapulmonary disease and mostly affects the ileocecal region. The presentation and radiologic findings in enteric tuberculosis can mimic Crohn's disease (CD). . Read More

View Article and Full-Text PDF

Gastric tuberculosis presenting as a large gastric ulcer.

BMJ Case Rep 2022 May 19;15(5). Epub 2022 May 19.

Department of Medicine, Zayed Military Hospital, Abu Dhabi, UAE.

While gastrointestinal (GI) tuberculosis (TB) accounts for 1%-3% of all TB cases worldwide, TB of the stomach is extremely rare and accounts for 1%-2% of all GI TB. Little is known about this entity, and most data are obtained from case reports. We report a case of a woman in her 60s who presented with a 2-week history of generalised weakness, fatigue and shivering, with severe loss of appetite on background history of dyspepsia and significant weight loss for the preceding 2 years. Read More

View Article and Full-Text PDF

MiR-25 blunts autophagy and promotes the survival of by regulating NPC1.

iScience 2022 May 22;25(5):104279. Epub 2022 Apr 22.

State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, Hubei, China.

(Mtb) evades host clearance by inhibiting autophagy. MicroRNA-25 (miR-25) expression was significantly up-regulated in the lung tissues of mice infected with Bacillus Calmette-Guerin (BCG) and macrophages infected with Mtb or BCG, especially in the early stages of infection. MiR-25 can significantly increase the survival of Mtb and BCG in macrophages. Read More

View Article and Full-Text PDF

Arginine-mediated gut microbiome remodeling promotes host pulmonary immune defense against nontuberculous mycobacterial infection.

Gut Microbes 2022 Jan-Dec;14(1):2073132

Department of Microbiology, Chungnam National University School of Medicine Daejeon, Korea.

Nontuberculous mycobacterial pulmonary diseases (NTM-PDs) are emerging as global health threats with issues of antibiotic resistance. Accumulating evidence suggests that the gut-lung axis may provide novel candidates for host-directed therapeutics against various infectious diseases. However, little is known about the gut-lung axis in the context of host protective immunity to identify new therapeutics for NTM-PDs. Read More

View Article and Full-Text PDF

Intestinal Perforation as a Paradoxical Reaction to Tuberculosis.

Cureus 2022 Apr 12;14(4):e24077. Epub 2022 Apr 12.

Family Medicine, Ambulatory Health Services, Al Ain, ARE.

Paradoxical reactions (PR) to tuberculosis (TB) treatments are characterized by an initial improvement of the clinical symptoms followed by a clinical or radiological deterioration of existing TB lesions or by the development of new lesions. PR in the gastrointestinal system is a rare phenomenon. Moreover, intestinal perforation is an uncommon but potentially fatal complication of intestinal TB. Read More

View Article and Full-Text PDF

Evaluation of the Therapeutic Effect of Antibiotics on Scrub Typhus: A Systematic Review and Network Meta-Analysis.

Front Public Health 2022 27;10:883945. Epub 2022 Apr 27.

School of Public Health, Nanjing Medical University, Nanjing, China.

Background: To explore the efficacy and safety of drugs in patients with scrub typhus.

Methods: For this systematic review and network meta-analysis, we searched PubMed, Embase, Web of Science, Cochrane Central Register of Clinical Trials, China National Knowledge Infrastructure (CNKI), and Wanfang data (WF) up to December 2021. All randomized controlled trials (RCTs) of antibiotics used to treat scrub typhus were included without language or date restrictions. Read More

View Article and Full-Text PDF

Non-tuberculosis extensive abdominal lymph node calcification leading to portal hypertension with esophageal and gastric variceal bleeding: a rare case report.

BMC Gastroenterol 2022 May 15;22(1):245. Epub 2022 May 15.

Department of Medical Imaging Center, Renmin Hospital, Hubei University of Medicine, No. 39 Chaoyang Middle Road, Shiyan, 442000, Hubei, China.

Background: Calcification of abdominal lymph node is a common clinical phenomenon, but it is extremely rare to cause serious adverse clinical outcomes. In the present case, the ruptured hemorrhage of the oesophagogastric fundic varices occurred as a result of portal hypertension due to compression of the portal vein by calcified lymph nodes. The patient was treated with medication, interventional therapy, endoscopic therapy, and surgery, respectively and the four different treatment options for the bleeding are worth summarizing. Read More

View Article and Full-Text PDF

COVID-19 infections in infants.

Sci Rep 2022 05 11;12(1):7765. Epub 2022 May 11.

Department of Infectious Diseases and Hepatology, Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.

The study aimed to analyse the clinical course of COVID-19 in 300 infants, selected from 1283 children diagnosed with COVID-19 between March and December 2020, registered in the SARSTerPED multicenter database. Most of the infants were registered in October and November 2020. 44% of the group were girls, and 56% were boys. Read More

View Article and Full-Text PDF

Extrapulmonalis tuberculosis - diagnosztikai és terápiás kihívás.

Orv Hetil 2022 May 8;163(19):750-757. Epub 2022 May 8.

1 Marosvásárhelyi "George Emil Palade" Orvosi, Gyógyszerészeti, Tudomány- és Technológiai Egyetem, Tüdőgyógyászati Tanszék Marosvásárhely Romania.

Összefoglaló. Bevezetés: Az extrapulmonalis tuberculosis incidenciája növekvő tendenciát mutat annak ellenére, hogy az elmúlt években világszerte csökkent a tuberculosisos esetek száma. Célkitűzés: Az extrapulmonalis tuberculosisra hajlamosító tényezők felmérése és a bakteriológiai és szövettani diagnosztizálási arányok meghatározása az egyes formák esetén. Read More

View Article and Full-Text PDF

Comparison of Prognosis Between Microscopically Positive and Negative Surgical Margins for Primary Gastrointestinal Stromal Tumors: A Systematic Review and Meta-Analysis.

Front Oncol 2022 19;12:679115. Epub 2022 Apr 19.

Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.

Background: This meta-analysis aimed to determine the prognostic impact of microscopically positive margins (R1) on primary gastrointestinal stromal tumors.

Methods: A literature search was performed using PubMed, Embase, Web of Science, and Cochrane Library for studies up to 23 November 2020. The pooled disease-free survival (DFS) and overall survival (OS) between R1 and negative margins (R0) were estimated using a random-effects model. Read More

View Article and Full-Text PDF

Epstein-Barr Virus-positive Mucocutanous Ulcer of the Uterine Cervix: Report of a Rare and Evolving Entity.

Int J Gynecol Pathol 2022 Apr 12. Epub 2022 Apr 12.

Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a newly described lymphoproliferative lesion characterized by the proliferation of EBV-positive atypical B cells in a variable inflammatory background associated with mucosal or cutaneous ulcers. Commonly involved sites include the oropharyngeal tract, skin, and gastrointestinal tract, with emerging reports describing EBVMCU of genitalia. To date, no lesions have been described of the uterine cervix. Read More

View Article and Full-Text PDF

Evaluating diagnostic performance of Truenat MTB Plus for gastrointestinal tuberculosis.

J Gastroenterol Hepatol 2022 May 2. Epub 2022 May 2.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Background And Aim: Prompt and accurate diagnosis of gastrointestinal tuberculosis (GITB) along with simultaneous detection of drug resistance is inevitable for tuberculosis elimination. Truenat MTB Plus (TruPlus), a chip-based real-time polymerase chain reaction assay, was evaluated for the first time for diagnosing GITB and detecting rifampicin resistance.

Methods: Fifty ileocecal biopsy specimens (5 microbiologically confirmed GITB [culture-positive], 25 clinically confirmed GITB [culture-negative], and 20 control patients) processed in the Department of Microbiology between 2011 and 2021 were subjected to TruPlus assay, Xpert MTB RIF assay multiplex polymerase chain reaction. Read More

View Article and Full-Text PDF

Esophagomediastinal fistula: a rare case of gastrointestinal tuberculosis.

Rev Esp Enferm Dig 2022 Apr 29. Epub 2022 Apr 29.

Gastroenterology, Hospital Pedro Hispano.

A 40-year-old male with history of HIV infection was admitted to the hospital with a one-month history of productive cough, vespertine fever, night sweats, loss of appetite and unintentional 10-Kg weight loss. Physical exam was remarkable for cachexia. Blood tests revealed a CD4+ T lymphocyte count of 23 cells/mm3 and HIV viral load of 837,678 copies/ml. Read More

View Article and Full-Text PDF