4,934 results match your criteria Tuberculosis Gastrointestinal

High rate of completion for weekly rifapentine plus isoniazid treatment in Chinese children with latent tuberculosis infection-A single center study.

PLoS One 2021 11;16(6):e0253159. Epub 2021 Jun 11.

Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.

Three months of weekly rifapentine plus isoniazid (3HP) is a short course regimen for latent tuberculosis infection treatment with satisfied safety and efficacy. However, research on its use in children is limited. In this study, we evaluated the completion rate and safety of the 3HP regimen among children in China. Read More

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Epstein-Barr virus-positive ulcer in the oral cavity.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S46-S50. Epub 2021 Mar 19.

Department of Oral Medicine and Pathology, Postgraduate Division, Dental School, National Autonomous University of Mexico, Mexico City, Mexico.

Epstein-Barr virus-positive ulcer (EBV + U) is a recently reported B cell lymphoproliferative disorder in the oral cavity, oropharynx, gastrointestinal tract and skin, principally in immunosuppressed patients. A 53-year-old female patient with rheumatoid arthritis treated with methotrexate, presenting ulcers of unknown duration on the dorsum and the lateral left border of the tongue. Excisional biopsy, histopathological analysis and histochemical stains for syphilis (Warthin-Starry), mycotic diseases (Grocott silver methenamine), tuberculosis (Ziehl-Neelsen), immunohistochemistry tests for herpesvirus type 8 (CMV), EBV (LMP-1) and DNA extraction for polymerase chain reaction (PCR) assay to CMV, EBV and herpes simplex virus-1 were performed. Read More

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Real world analysis on the efficacy and safety of anti-tumor necrosis factor therapy in patients with stricturing Crohn's disease.

Sci Rep 2021 Jun 3;11(1):11704. Epub 2021 Jun 3.

Department of Gastroenterology, All India Institute of Medical Sciences, Ansari Nagar, New Delh, 110029, India.

Crohn's disease (CD) is often complicated by strictures and associated with increased risk for surgery. Inflammatory strictures respond to medical therapy, and anti-tumor necrosis factor (TNF) therapy is often used after the failure of steroids. However, data on efficacy of anti-TNF therapy in stricturing CD is limited. Read More

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Long-Term Safety and Efficacy of Risankizumab Treatment in Patients with Crohn's Disease: Results from the Phase 2 Open-Label Extension Study.

J Crohns Colitis 2021 Jun 2. Epub 2021 Jun 2.

Amsterdam University Medical Center, Amsterdam, Netherlands.

Background And Aims: Risankizumab, an interleukin-23 antibody, demonstrated efficacy and acceptable safety in a phase 2 study of patients with moderate-to-severe refractory Crohn's disease. This open-label extension investigated the long-term safety, pharmacokinetics, immunogenicity, and efficacy of risankizumab in responders to risankizumab in the parent phase 2 study.

Methods: Enrolled patients had achieved clinical response (decrease in Crohn's Disease Activity Index from baseline ≥100) without clinical remission (Crohn's Disease Activity Index <150) at Week 26, or clinical response and/or remission at Week 52 in the parent phase 2 study and received open-label subcutaneous risankizumab 180 mg every 8 weeks. Read More

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Application value of tissue tuberculosis antigen combined with Xpert MTB/RIF detection in differential diagnoses of intestinal tuberculosis and Crohn's disease.

BMC Infect Dis 2021 May 28;21(1):498. Epub 2021 May 28.

Tuberculosis Diagnosis and Treatment Center, Hangzhou Red Cross Hospital, Hangzhou, 310003, Zhejiang, China.

Background: The purpose of this study was to examine the value of Xpert MTB/RIF assay and detection of additional Mycobacterium tuberculosis complex (MTBC) species antigens from intestinal tissue samples in differentiating intestinal tuberculosis (ITB) from Crohn's disease (CD).

Methods: Several clinical specimens of intestinal tissue obtained by either endoscopic biopsy or surgical excision were used for mycobacteriologic solid cultures,Xpert MTB/RIF assays, immunohistochemistry, and histological examinations. Four antigens (38KDa, ESAT-6, MPT64, and Ag85 complex) of MTBC in the intestinal tissue were detected by immunohistochemical analysis. Read More

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Movement of Prion-Like α-Synuclein along the Gut-Brain Axis in Parkinson's Disease: A Potential Target of Curcumin Treatment.

Eur J Neurosci 2021 May 27. Epub 2021 May 27.

Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

A pathological hallmark of the neurodegenerative disorder, Parkinson's disease (PD), is aggregation of toxic forms of the pre-synaptic protein, alpha-synuclein (α-synuclein) in structures known as Lewy bodies. Alpha-synuclein pathology is found in both the brain and gastrointestinal tracts of affected individuals, possibly due to the movement of this protein along the vagus nerve which connects the brain to the gut. In this review, we discuss current insights into the spread of α-synuclein pathology along the gut-brain axis which could be targeted for therapeutic interventions. Read More

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Sustained declines in age group-specific rotavirus infection and acute gastroenteritis in vaccinated and unvaccinated individuals during the five years since Rotavirus vaccine introduction in England.

Clin Infect Dis 2021 May 27. Epub 2021 May 27.

Immunisation and Counter-Measures Division, National Infection Service, Public Health England, 61 Colindale Avenue, London, NW9 5EQ, UK.

Background: The introduction of an oral live-attenuated monovalent rotavirus vaccine (Rotarix ®) into the UK infant immunisation programme in July 2013 was associated with large reductions in laboratory-confirmed rotavirus infections and hospitalisations due to acute gastroenteritis (AGE) within 12 months. Here we report the five-year impact of the programme in England.

Methods: Individuals with laboratory-confirmed rotavirus infections during 2000-2018 and all-cause hospitalisations for AGE during 2007-2018 were identified using national electronic records. Read More

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Primary duodenal tuberculosis complicated with perforation: A review of literature and case report.

Ann Med Surg (Lond) 2021 Jun 12;66:102392. Epub 2021 May 12.

Department of Digestive Surgery 'A', La Rabta Hospital University, Faculty of Medicine of Tunis, Tunisia.

Tuberculous (TB) disease remains an endemic pathology in Tunisia. the ileocecal region is the predominant site of involvement while gastroduodenal tuberculosis is very rare, this form is often presenting as one of the complications, mainly upper gastrointestinal stenosis or exceptionally as a perforation. We describe a case of female patient aged 33 years-old presented with a 2-day history of acute abdominal pain, with a tenderness of the right hypochondrium and the epigastrium, ultrasound of the abdomen revealed gallbladder distension with a wall thickening. Read More

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Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2.

Nat Med 2021 May 26. Epub 2021 May 26.

Gastrointestinal and Lymphoma Unit, The Royal Marsden NHS Foundation Trust, Sutton, UK.

Patients with cancer are currently prioritized in coronavirus disease 2019 (COVID-19) vaccination programs globally, which includes administration of mRNA vaccines. Cytokine release syndrome (CRS) has not been reported with mRNA vaccines and is an extremely rare immune-related adverse event of immune checkpoint inhibitors. We present a case of CRS that occurred 5 d after vaccination with BTN162b2 (tozinameran)-the Pfizer-BioNTech mRNA COVID-19 vaccine-in a patient with colorectal cancer on long-standing anti-PD-1 monotherapy. Read More

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Management of abdominal tuberculosis in a community-based hospital in a high-income developing country.

World J Emerg Surg 2021 May 26;16(1):25. Epub 2021 May 26.

Department of Surgery, College of Medicine and Health Sciences, UAE University, Al-Ain, UAE.

Background: The delayed diagnosis and management of abdominal tuberculosis increases its mortality. We aimed to study the clinical presentation, management, and outcome of patients who had abdominal tuberculosis and were treated at Al-Ain Hospital, Al-Ain City, United Arab Emirates.

Methods: All patients who had abdominal tuberculosis and were treated at Al-Ain Hospital between January 2011 and December 2018 were studied. Read More

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Ileocecal and hepatic tuberculosis mimicking a metastatic cecal malignancy: Case report.

Clin Case Rep 2021 May 29;9(5):e04101. Epub 2021 Mar 29.

Department of general surgery, Trauma and Burns Center Ben Arous Tunisia.

We wish to highlight that on encountering a suspicious hepatic and a colonic lesion, the possibility of TB should also be kept in mind apart from the obvious possibility of metastasis of a colonic cancer especially in an endemic country like Tunisia. Read More

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Nutritional, antimicrobial and medicinal properties of Camel's milk: A review.

Saudi J Biol Sci 2021 May 21;28(5):3126-3136. Epub 2021 Feb 21.

Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt.

Camel's milk is an important part of staple diet in several parts of the world, particularly in the arid and semi-arid zones. Camel's milk is rich in health-beneficial substances, such as bioactive peptides, lactoferrin, zinc, and mono and polyunsaturated fatty acids. These substances could help in the treatment of some important human diseases like tuberculosis, asthma, gastrointestinal diseases, and jaundice. Read More

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Gastrointestinal and Abdominal Tuberculosis.

Haluk Eraksoy

Gastroenterol Clin North Am 2021 Jun;50(2):341-360

Department of Infectious Diseases and Clinical Microbiology, Istanbul Faculty of Medicine, Istanbul University, TR-34093 Istanbul, Turkey. Electronic address:

Gastrointestinal (GI) tuberculosis (TB) remains a significant problem worldwide, and may involve the luminal GI tract from oral cavity to perianal area in addition to associated viscera and peritoneum. Although GI TB more commonly affects immunocompromised hosts, it can also occur in immunocompetent people. Diagnosis is difficult because it usually mimics a malignancy or inflammatory bowel disease. Read More

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Basidiobolomycosis of Right Colon Mimicking as Carcinoma of Colon.

ACG Case Rep J 2021 May 14;8(5):e00573. Epub 2021 May 14.

Department of Surgery, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Gastrointestinal basidiobolomycosis (GIB) is a rare fungal infection with limited geographic distribution. However, the incidence of GIB has shown an increasing trend because of globalization and frequent traveling. GIB is commonly seen to mimic gastrointestinal malignancy and other diseases such as intestinal tuberculosis and inflammatory bowel disease. Read More

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Association of -c.894G>T transversion with susceptibility to metabolic syndrome in Azar-cohort population: A case-control study and analysis of the SNP molecular effects.

Iran J Basic Med Sci 2021 Mar;24(3):408-419

Tuberculosis and Lung Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Objectives: We investigated whether -c.894G>T transversion (rs1799983), which causes the substitution of glutamate with aspartate (E298D) in the oxygenase domain of endothelial nitric oxide synthase (eNOS), is associated with susceptibility to metabolic syndrome (MetS) risk in Iranian-Azerbaijanis.

Materials And Methods: The frequencies of the alleles and genotypes were compared in the 300 cases and 300 controls using PCR-RFLP assay. Read More

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Assessing the prevalence and effect of adverse drug reactions among patients receiving first line anti-tubercular medicines in the Tamale Teaching Hospital, Ghana.

Pan Afr Med J 2021 19;38:191. Epub 2021 Feb 19.

Pharmacy Directorate, Tamale Teaching Hospital, Tamale, Northern Region, Ghana.

Introduction: tuberculosis (TB) remains a global major health problem, especially in developing countries. Although treatment regimen for TB has been highly effective, treatment-related adverse effects account for significant morbidity leading to reduced effectiveness of therapy and high default rate. This study evaluated the nature and occurrence of Adverse Drug Reactions (ADRs) in patients receiving first line antitubercular therapy (ATT) in Tamale Teaching Hospital (TTH) and its effects on adherence. Read More

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Direct Comparison of Risankizumab and Fumaric Acid Esters in Systemic-Therapy-Naive Patients With Moderate to Severe Plaque Psoriasis: A Randomized Controlled Trial.

Br J Dermatol 2021 May 15. Epub 2021 May 15.

Dermatologikum, Hamburg, Germany.

Background: Fumaric acid esters (FAEs; Fumaderm ) are the most frequently prescribed first-line systemic treatment for moderate-to-severe plaque psoriasis in Germany. Risankizumab (Skyrizi ) is a humanized IgG1 monoclonal antibody that specifically binds to the p19 subunit of interleukin-23.

Objective: This study compared risankizumab treatment with FAEs in psoriasis patients. Read More

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[Features and choice of surgical strategy in patients with gastrointestinal fistulas].

Khirurgiia (Mosk) 2021 (5):58-62

Samara State Medical University, Samara, Russia.

Objective: To evaluate the features and choice of surgical strategy in patients with gastrointestinal fistula based on classification of their types.

Material And Methods: There were 398 patients with gastrointestinal fistula. Fistula type 1 was found in 126 (31. Read More

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Abdominal Ascites of Unknown Origin: Diagnostic Accuracy of Adenosine Deaminase for Tuberculous Peritonitis.

Case Rep Gastroenterol 2021 Jan-Apr;15(1):418-423. Epub 2021 Apr 6.

Gastroenterology, BronxCare Health System, Bronx, New York, USA.

The occurrence of tuberculosis (TB) is exceedingly rare in the United States (US), and incidence has steadily declined since 1993, but the pace of decline has slowed in recent years. The US TB rate during 2019 declined to 2.7 cases per 100,000 persons, the lowest level on record. Read More

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Retrospective Study of Bone-TB in Oman: 2002-2019.

J Epidemiol Glob Health 2021 Apr 26. Epub 2021 Apr 26.

Directorate of Drug Store, Injection Section, Directorate General of Medical Supplies, Muscat, Sultanate of Oman.

Objective: Little information is available about the etiology, pathophysiology, risk factors, and epidemiologic features of Bone Tuberculosis (Bone-TB). In this work, we present the epidemiological data about the Bone-TB in the Sultanate of Oman.

Methods: Retrospectively, we identified and assessed those patients who were diagnosed with Bone-TB between January 2002 and December 2019 at Khoula Hospital. Read More

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Acute urinary retention in the first and second-trimester of pregnancy: Three case reports.

World J Clin Cases 2021 May;9(13):3130-3139

Department of Obstetrics, Sichuan Provincial Hospital for Women and Children, Chengdu 610000, Sichuan Province, China.

Background: Acute urinary retention (AUR) is rare during pregnancy.

Case Summary: We report on three pregnant women with AUR between the 10 and 18 wk of gestation. Case 1 was first diagnosed as urinary tract infection and developed a urinary tract infection due to urinary retention caused by urethral obstruction. Read More

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Treatment and outcomes of Multidrug-resistant tuberculosis in Auckland 1995-2018.

Intern Med J 2021 May 7. Epub 2021 May 7.

Department of Infectious Disease, Auckland City Hospital, Auckland, New Zealand.

Introduction: New Zealand has a low burden of tuberculosis, however multidrug-resistant tuberculosis (MDR-TB) still represents a challenge for clinicians. This is the first description of clinical aspects of MDR-TB in New Zealand.

Methods: Clinical data were obtained for patients treated for MDR-TB at Auckland District Health Board (ADHB). Read More

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Update on Immunology of COVID-19 Disease and Potential Strategy for Controlling.

Tanaffos 2020 Dec;19(4):274-290

Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Coronavirus disease 2019 (COVID-19) is caused by a novel form of the coronavirus that caused severe acute respiratory syndrome (SARS). SARS-CoV-2 raised in China and has broadcast to 261 countries globally. SARS-CoV-2 a member of β-coronavirus family and has an almost matching genome sequence to a bat coronavirus, pointing to the bat as the natural host before it was transmitted to humans. Read More

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December 2020

Case report: histopathology and molecular pathology analysis on enteric tissue of a COVID-19 patient.

Diagn Pathol 2021 May 5;16(1):40. Epub 2021 May 5.

Department of Infectious Disease, Shanghai Public Health Clinical center, Fudan University, Shanghai, China.

Aims: Patients with COVID-19 can also have enteric symptoms. Here we analyzed the histopathology of intestinal detachment tissue from a patient with COVID-19.

Methods: The enteric tissue was examined by hematoxylin & eosin stain, PAS (Periodic acid-Schiff) staining, Gram staining, Ziehl-Neelsen stain and Grocott's Methenamine Silver (GMS) Stain. Read More

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DOCK8-related Immunodeficiency Syndrome (DIDS): Report of Novel Mutations in Iranian Patients.

J Mol Neurosci 2021 May 4. Epub 2021 May 4.

Division of Medical Genetics, Tabriz Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

DOCK8 immunodeficiency syndrome (DIDS) is a rare autosomal recessive (AR) disorder characterized by elevated serum IgE levels, eosinophilia, recurrent cutaneous infections, severe eczema, and sinopulmonary and gastrointestinal infections. This syndrome is a multisystem disease that is associated with both immune deficiency and neurological complications. In this study, we describe the clinical characteristics of two Iranian patients with DOCK8 deficiency and propose possible mechanisms for this condition. Read More

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Expanding the spectrum of reactive arthritis (ReA): classic ReA and infection-related arthritis including poststreptococcal ReA, Poncet's disease, and iBCG-induced ReA.

Rheumatol Int 2021 May 1. Epub 2021 May 1.

Department of Internal Medicine and Rheumatology, Juntendo University Koshigaya Hospital, Saitama, Japan.

Reactive arthritis (ReA) is a form of sterile arthritis that occurs secondary to an extra-articular infection in genetically predisposed individuals. The extra-articular infection is typically an infection of the gastrointestinal tract or genitourinary tract. Infection-related arthritis is a sterile arthritis associated with streptococcal tonsillitis, extra-articular tuberculosis, or intravesical instillation of bacillus Calmette-Guérin (iBCG) therapy for bladder cancer. Read More

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Single-pill sofosbuvir and daclatasvir for treating hepatis C in patients co-infected with human immunodeficiency virus.

Int J Clin Pract 2021 Apr 30:e14304. Epub 2021 Apr 30.

Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: The current recommendation for treating hepatitis C virus (HCV) in HIV patients includes the combination of sofosbuvir (SOF) and daclatasvir (DCV). DCV should be used at different doses to compensate for interactions with antiretroviral therapy (ART). Up to three pills a day might be required which will significantly add to the pill burden of these patients. Read More

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Diabesity Associated with Poor COVID-19 Outcomes among Hospitalized Patients.

J Obes Metab Syndr 2021 Apr 30. Epub 2021 Apr 30.

Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Although numerous studies have investigated obesity's negative effect on coronavirus disease 2019 (COVID-19) outcomes, only a limited number focused on this association in diabetic patients. In this study, we analyzed the association between obesity and COVID-19 outcome (death, intensive care unit [ICU] admission, mechanical ventilation needs, quick Sequential Organ Failure Assessment [qSOFA] score, and confusion, urea, respiratory rate, blood pressure [CURB-65] scores) for hospitalized diabetic patients.

Methods: In this prospective hospital-based registry of patients with COVID-19 in East Azerbaijan, Iran, 368 consecutive diabetic patients with COVID-19 were followed from admission until discharge or death. Read More

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and Evaluations of Anti- Activity of Benzohydrazones Compounds.

Microb Drug Resist 2021 Apr 28. Epub 2021 Apr 28.

Postgraduate Program in Health Sciences, State University of Maringá, Maringá, Brazil.

Tuberculosis is a disease caused by , with high mortality rates and an extended treatment that causes severe adverse effects, besides the emergence of resistant bacteria. Therefore, the search for new compounds with anti- activity has considerably increased in recent years. In this context, benzohydrazones are significant compounds that have antifungal and antibacterial action. Read More

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Overexpression of microRNA-340-5p Ameliorates Inflammatory Response and Intracellular Survival of in Alveolar Type II Cells.

Infect Drug Resist 2021 21;14:1573-1584. Epub 2021 Apr 21.

Department of Geriatric Medicine, People's Hospital of Jiangxi Province, Nanchang, 330006, Jiangxi, People's Republic of China.

Background: The importance of microRNAs (miRs) has been documented in infections. This study estimated the role of miR-340-5p in (Mtb)-infected alveolar type II cells.

Methods: The microarray of GEO database was analyzed to find the differentially expressed miRs caused by Mtb infection, and miR-340-5p was selected as the research object. Read More

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