4,730 results match your criteria Tuberculosis Gastrointestinal


Monogenic Primary Immunodeficiency Disorder Associated with Common Variable Immunodeficiency and Autoimmunity.

Int Arch Allergy Immunol 2020 Jul 2:1-9. Epub 2020 Jul 2.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran,

Background: Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction of B cells and decreased immunoglobulin levels. In this study, our aim is to evaluate clinical, immunological, and molecular data of patients with a primary clinical diagnosis of CVID and autoimmune phenotype with a confirmed genetic diagnosis.

Methods: Among 297 patients with CVID, who were registered in the Iranian Primary Immunodeficiency Registry at Children's Medical Center Hospital in Iran, 83 patients have been genetically examined and 27 patients with autoimmunity and confirmed genetic mutations were selected for analysis. Read More

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http://dx.doi.org/10.1159/000508817DOI Listing

Paroxetine Administration Affects Microbiota and Bile Acid Levels in Mice.

Front Psychiatry 2020 4;11:518. Epub 2020 Jun 4.

Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.

Recent interest in the role of microbiota in health and disease has implicated gut microbiota dysbiosis in psychiatric disorders including major depressive disorder. Several antidepressant drugs that belong to the class of selective serotonin reuptake inhibitors have been found to display antimicrobial activities. In fact, one of the first antidepressants discovered serendipitously in the 1950s, the monoamine-oxidase inhibitor Iproniazid, was a drug used for the treatment of tuberculosis. Read More

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http://dx.doi.org/10.3389/fpsyt.2020.00518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7287167PMC

Meta-analysis on Effectiveness and Safety of Moxifloxacin in Treatment of Multidrug Resistant Tuberculosis in Adults.

Medicine (Baltimore) 2020 Jun;99(25):e20648

Department of Dermatology & STD, The Third Central Hospital of Tianjin.

Background: Moxifloxacin, a fourth generation fluoroquinolone, which has good antibacterial activity against both Gram-positive cocci and Gram-negative bacteria. To date, there are no meta-analysis to evaluate the efficacy and safety of moxifloxacin for multi-drug resistant tuberculosis (MDR-TB) treatment. This meta-analysis to explore the efficacy and safety of the moxifloxacin in treatment of MDR-TB in adults. Read More

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http://dx.doi.org/10.1097/MD.0000000000020648DOI Listing

Tuberculous peritonitis; The effectiveness of diagnostic laparoscopy and the perioperative infectious prevention: A case report.

Int J Surg Case Rep 2020 Jun 13;72:326-329. Epub 2020 Jun 13.

Department of Gastrointestinal Tract Surgery, Fukushima Medical University, Japan.

Background: Tuberculous peritonitis (TBP) is uncommon in Japan, and its diagnosis with conventional methods is time taking and requires a high clinical index of suspicion. Laparoscopy with peritoneal biopsy is a tool for rapid and accurate diagnosis of TBP. However, few cases have mentioned the infectious control and prevention during the perioperative period. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.06.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7305365PMC

Gastric tuberculosis mimicking liver abscess - A case report.

Indian J Tuberc 2020 Apr 1;67(2):274-276. Epub 2020 Feb 1.

Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Science, Raibareli Road, Lucknow 226014, India.

Tuberculosis of the stomach is quite rare, both as a primary or secondary infection. It has varied presentation ranging from non-specific abdominal pain and constitutional symptoms to hematemesis, gastric outlet obstruction and pyrexia of unknown origin. Here, we report a rare, interesting case of locally advanced gastric tuberculosis, which morphologically mimicked liver abscess initially in a young, immunocompetent patient presenting with fever and abdominal pain. Read More

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http://dx.doi.org/10.1016/j.ijtb.2020.01.012DOI Listing

Differentiating intestinal tuberculosis and Crohn disease: Quo Vadis.

Authors:
Vishal Sharma

Expert Rev Gastroenterol Hepatol 2020 Jun 30:1-4. Epub 2020 Jun 30.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research , Chandigarh, India.

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http://dx.doi.org/10.1080/17474124.2020.1785870DOI Listing

A Case of Miliary Perinatal Tuberculosis in a Preterm Newborn Infant Presenting as Peritonitis.

Cureus 2020 May 9;12(5):e8036. Epub 2020 May 9.

Pediatrics Section, Marie Curie Children's Emergency Hospital, Bucharest, ROU.

Perinatal tuberculosis (TB) is a rare disease with nonspecific clinical symptoms that can result in delayed treatment, and contribute to high morbidity and mortality. We report a case of perinatal TB in a 25-day-old newborn who presented with fever, respiratory distress, disseminated intravascular coagulation (DIC), and marked abdominal distension with hepatosplenomegaly. Further workup revealed culture negative sepsis, peritonitis, and diffuse nodular infiltrate in the lungs, liver, and spleen. Read More

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http://dx.doi.org/10.7759/cureus.8036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282365PMC

Assessment of Infection of the Intestine in Three Patients and a Systematic Review of Case Reports.

Open Forum Infect Dis 2020 Jun 27;7(6):ofaa128. Epub 2020 Apr 27.

Department of Respiratory and Critical Care Medicine, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, China.

Background: Hematogenous dissemination of can result in multiorgan involvement (skin, lung, and reticuloendothelial system involvement); however, few studies have reported intestinal infections. We investigated clinical features, management, and patient outcomes concerning -related intestinal infections.

Methods: Patients with between August 2012 and April 2019 at The First Affiliated Hospital of Guangxi Medical University, China, were retrospectively analyzed. Read More

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http://dx.doi.org/10.1093/ofid/ofaa128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264840PMC

[Natural Killer/T cell primary extranasal ileum lymphoma].

Rev Peru Med Exp Salud Publica 2020 Jan-Mar;37(1):160-163. Epub 2020 Jun 8.

Servicio de Oncohematología Clínica, Hospital Nacional Arzobispo Loayza, Lima, Perú.

Primary extranodal Natural Killer / T cell lymphoma (NKTL) on gastrointestinal tract is an uncommon and aggressive neoplasm. We present the case of a 51-year-old immunocompetent patient with a 2-month history of abdominal pain. Colonoscopy findings showed ileal ulcerations, so studies were carried out to rule out Crohn's disease and intestinal tuberculosis. Read More

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http://dx.doi.org/10.17843/rpmesp.2020.371.4331DOI Listing

Misdiagnosis of a multi-organ involvement hematogenous disseminated tuberculosis as metastasis: a case report and literature review.

Infect Dis Poverty 2020 Jun 9;9(1):66. Epub 2020 Jun 9.

Clinical Research Center, the Second Hospital of Nanjing, Nanjing University of Chinese Medicine, 1-1 Zhongfu Road, Gulou District, Nanjing, Jiangsu Province, 210003, China.

Background: Tuberculosis (TB) is a great mimicker and diagnostic chameleon, and prone to be diagnosed as malignancy. Even though many reports have described the differences between pulmonary TB and lung cancer, the atypical systemic hematogenous disseminated TB (HDTB) is very rare and more confusing in clinical practice.

Case Presentation: A 73-year-old man, HIV-negative, was hospitalized to the local county hospital because of chest pain, low-grade fever, asthenia, anorexia and weight loss for the pasting two months. Read More

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http://dx.doi.org/10.1186/s40249-020-00681-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285721PMC

Gut Dysbiosis Thwarts the Efficacy of Vaccine Against .

Front Immunol 2020 19;11:726. Epub 2020 May 19.

CSIR-Institute of Microbial Technology, Chandigarh, India.

The generation of enduring protective immunity by vaccines is of utmost importance. Intriguingly, there is considerable variation in the efficacy of vaccines amongst individuals. Various studies have shown that normal flora of gastrointestinal tract plays a vital role in maintaining host homeostasis and immunity. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7248201PMC

Abdominal Involvement in Children With Bacteriologically Confirmed Tuberculosis: A Five-year Experience From Cape Town, South Africa.

Pediatr Infect Dis J 2020 Jun 1. Epub 2020 Jun 1.

From the Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Abdominal tuberculosis (TB) in children is poorly described and often poses a diagnostic challenge. We evaluated abdominal involvement in children presenting with bacteriologically confirmed TB.

Methods: We undertook a retrospective study at Tygerberg Hospital, Cape Town, from January 1, 2014, through December 31, 2018, of all children (<13 years) diagnosed with bacteriologically confirmed TB, in whom abdominal involvement was found. Read More

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http://dx.doi.org/10.1097/INF.0000000000002749DOI Listing

FDG-PET-CT Enterography Helps Determine Clinical Significance of Suspected Ileocecal Thickening: A Prospective Study.

Dig Dis Sci 2020 Jun 1. Epub 2020 Jun 1.

Department of Gastroenterology, Postgraduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Background: Ileocecal thickening (ICT) on imaging could result from diverse etiologies but may also be clinically insignificant.

Aim: Evaluation of role of combined 2-deoxy-2-fluorine-18-fluoro-D-glucose(F-FDG)-positron emission tomography and computed tomographic enterography (PET-CTE) for determination of clinical significance of suspected ICT.

Methods: This prospective study enrolled consecutive patients with suspected ICT on ultrasound. Read More

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http://dx.doi.org/10.1007/s10620-020-06361-9DOI Listing
June 2020
2.550 Impact Factor

Determination and Identification of Antibiotic Drugs and Bacterial Strains in Biological Samples.

Molecules 2020 May 31;25(11). Epub 2020 May 31.

Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100 Torun, Poland.

Antibiotics were initially natural substances. However, nowadays, they also include synthetic drugs, which show their activity against bacteria, killing or inhibiting their growth and division. Thanks to these properties, many antibiotics have quickly found practical application in the fight against infectious diseases such as tuberculosis, syphilis, gastrointestinal infections, pneumonia, bronchitis, meningitis and septicemia. Read More

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http://dx.doi.org/10.3390/molecules25112556DOI Listing

The pharmacokinetics of para-aminosalicylic acid and its relationship to efficacy and intolerance.

Br J Clin Pharmacol 2020 May 29. Epub 2020 May 29.

Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Following its introduction as an antituberculosis agent close to 75 years ago, the use of para-aminosalicylic acid (PAS) has been limited by gastrointestinal intolerance and multiple formulations were produced in attempts to reduce its occurrence. More recently, an enteric-coated, granular, slow-release PAS formulation (PASER) was introduced and is now in wide-spread use for the treatment of drug-resistant tuberculosis. The current PASER dosing regimen is based on recommendations derived from older studies using a variety of different PAS formulations and relegate PAS to a role as an exclusively bacteriostatic agent. Read More

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http://dx.doi.org/10.1111/bcp.14395DOI Listing

Gastrointestinal trichobezoar: An experience with 17 cases.

J Pediatr Surg 2020 May 5. Epub 2020 May 5.

Department of Pediatric Surgery, The Children's Hospital and the Institute of Child Health, Lahore, Pakistan.

Background: Trichobezoar is an exceedingly rare entity in children and mimics other chronic ailments such as abdominal tuberculosis or malignancy. Delayed diagnosis and management result in various complications. The study was conducted to describe our experience with 17 consecutive cases of gastrointestinal tract (GIT) trichobezoars. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.04.020DOI Listing
May 2020
1.311 Impact Factor

Coronaviruses pathogenesis, comorbidities and multi-organ damage - A review.

Life Sci 2020 Aug 22;255:117839. Epub 2020 May 22.

Department of Biomedical Sciences, School of Biosciences and Technology, VIT, Vellore, Tamil Nadu 632014, India. Electronic address:

Human coronaviruses, especially COVID-19, is an emerging pandemic infectious disease with high morbidity and mortality. Coronaviruses are associated with comorbidities, along with the symptoms of it. SARS-CoV-2 is one of the highly pathogenic coronaviruses that causes a high death rate compared to the SARS-CoV and MERS. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117839DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243768PMC

Hodkgin lymphoma concomitant of tuberculosis, a therapeutic challenge for multidisciplinary management.

Cancer Radiother 2020 Jul 19;24(4):335-339. Epub 2020 May 19.

Department of Radiation Oncology, Institut Curie, 25, rue d'Ulm, 75005 Paris, France; University of Versailles, St Quentin, France.

Hodgkin lymphoma (HL) is a disease characterized by a high curability rate, and the treatment benefit-risk balance must be carefully addressed to achieve complete disease control with low risk of long-term toxicities. Most patients are treated with a combination of chemotherapy and radiotherapy, after disease staging and response to treatment evaluated by FDG PET/CT. We report the case of a 28-year-old patient concomitantly diagnosed of a Hodgkin lymphoma and active tuberculosis. Read More

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http://dx.doi.org/10.1016/j.canrad.2020.02.005DOI Listing

Chronic vomiting in children: A prospective study reveals rumination syndrome is an important etiology that is underdiagnosed and untreated.

Indian J Gastroenterol 2020 Apr 20;39(2):196-203. Epub 2020 May 20.

Department of Pediatric Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, 226 014, India.

Background: The diagnosis of rumination syndrome is frequently overlooked, and under-recognized; children are subjected to unnecessary testing and inappropriate treatment for a condition which can be diagnosed clinically and managed easily. In the first ever systematic exploration of this condition from India, we present a prospective study on children with chronic vomiting in which rumination emerged as the predominant cause.

Methods: This was a prospective study in which all consecutive children (5-18 years) presenting with chronic or recurrent vomiting of at least 2-month duration were enrolled. Read More

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http://dx.doi.org/10.1007/s12664-020-01025-yDOI Listing

Challenging diagnosis of gastrointestinal tuberculosis made simpler with multi-targeted loop-mediated isothermal amplification assay.

Eur J Gastroenterol Hepatol 2020 May 15. Epub 2020 May 15.

Departments of Medical Microbiology.

Background: Prompt and accurate diagnosis of gastrointestinal tuberculosis (GITB) is highly challenging. Current conventional techniques lack sensitivity and are time-consuming. Multi targeted loop-mediated isothermal amplification (LAMP) using two targets (IS6110 and MPB64) is a promising technique for rapid diagnosis of TB. Read More

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http://dx.doi.org/10.1097/MEG.0000000000001765DOI Listing

Assessment of the Interaction Potential of (L.) Extracts on CYP2B6, 3A4, and Rifampicin Metabolism.

Front Pharmacol 2020 30;11:517. Epub 2020 Apr 30.

Division of Clinical Pharmacology, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa.

L. or basilicum is a common culinary herb, used as a traditional medicine for various medical conditions including HIV/AIDS and tuberculosis, in Africa. The objective of this study was to evaluate the effect of methanol, ethanol, aqueous and ethyl acetate extracts of the dried leaves and inflorescence of , on the activity of cytochrome P450 enzymes (CYPs) CYP2B6 and 3A4, as well as esterase-mediated metabolism of rifampicin to 25--desacetyl rifampicin (25ODESRIF). Read More

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http://dx.doi.org/10.3389/fphar.2020.00517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204527PMC

Development of a long-acting direct-acting antiviral system for hepatitis C virus treatment in swine.

Proc Natl Acad Sci U S A 2020 Jun 18;117(22):11987-11994. Epub 2020 May 18.

Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139;

Chronic hepatitis C virus (HCV) infection is a leading cause of cirrhosis worldwide and kills more Americans than 59 other infections, including HIV and tuberculosis, combined. While direct-acting antiviral (DAA) treatments are effective, limited uptake of therapy, particularly in high-risk groups, remains a substantial barrier to eliminating HCV. We developed a long-acting DAA system (LA-DAAS) capable of prolonged dosing and explored its cost-effectiveness. Read More

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http://dx.doi.org/10.1073/pnas.2004746117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7275718PMC

Cancer incidence attributable to tuberculosis in 2015: global, regional, and national estimates.

BMC Cancer 2020 May 12;20(1):412. Epub 2020 May 12.

Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Background: Tuberculosis is associated with increased risk of cancer. However, the impact of tuberculosis on global cancer burden is unknown.

Methods: We performed random-effects meta-analyses and meta-regressions of studies reporting the association between tuberculosis and cancer risks by searching PubMed, Web of Science, Embase, Cochrane library, and CINAHL from inception to 1 June 2019. Read More

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http://dx.doi.org/10.1186/s12885-020-06891-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7218646PMC
May 2020
3.362 Impact Factor

Anti-tubercular therapy given to differentiate Crohn's disease from intestinal tuberculosis predisposes to stricture formation.

J Crohns Colitis 2020 May 5. Epub 2020 May 5.

Department of Gastroenterology and Human Nutrition, All India Institute of Medical Sciences, New Delhi, India.

Background And Aim: Treatment trial with anti-tubercular therapy (ATT) is a common strategy in tuberculosis-endemic countries in case of a diagnostic dilemma between intestinal tuberculosis and Crohn's disease (CD). Our aim was to determine the long-term clinical course of patients who received ATT before an eventual diagnosis of CD was made.

Methods: We performed retrospective-comparison between CD patients who received ≥6 months of ATT vs those who did not receive ATT. Read More

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http://dx.doi.org/10.1093/ecco-jcc/jjaa091DOI Listing
May 2020
6.234 Impact Factor

Disseminated tuberculosis presenting as massive lower gastrointestinal bleeding.

J Family Med Prim Care 2020 Feb 28;9(2):1226-1228. Epub 2020 Feb 28.

Department of Medicine, Sucheta Kriplani Hospital & LHMC, New Delhi, India.

Intestinal tuberculosis has varied clinical presentations and often requires high index of suspicion for clinching the diagnosis. We report a case of an 18-year-old male who presented with abrupt onset of massive lower gastrointestinal bleeding and was diagnosed to have ileocecal tuberculosis. This case signifies the need to consider the possibility of intestinal tuberculosis as a cause of severe hematochezia among other etiologies to prevent mortality and morbidity. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_1000_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114054PMC
February 2020

HIV-TB co-infection with clinical presentation, diagnosis, treatment, outcome and its relation to CD4 count, a cross-sectional study in a tertiary care hospital in coastal Karnataka.

J Family Med Prim Care 2020 Feb 28;9(2):1160-1165. Epub 2020 Feb 28.

Department of Microbiology, Fr. Muller Medical College, Kankanady, Mangalore, Karnataka, India.

Introduction: Tuberculosis (TB) is the leading killer and the commonest opportunistic infection (OI) in human immunodeficiency virus (HIV) infected individuals with 0.3 million deaths in 2017. When HIV and TB co-infection occurs, they form a deadly combination with each accelerating the progression of the other, resulting in increased morbidity and mortality. Read More

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http://dx.doi.org/10.4103/jfmpc.jfmpc_950_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7113982PMC
February 2020

Tuberculosis contact investigation and short-course preventive therapy among young children in Africa.

Int J Tuberc Lung Dis 2020 Apr;24(4):452-460

International Union Against Tuberculosis and Lung Disease, Paris.

The largest cities in Benin, Burkina Faso, Cameroon and Central African Republic. To demonstrate the feasibility and document the effectiveness of household contact investigation and preventive therapy in resource-limited settings. Children under 5 years living at home with adults with bacteriologically confirmed pulmonary tuberculosis (TB) were screened using questionnaire, clinical examination, tuberculin skin test and chest X-ray. Read More

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http://dx.doi.org/10.5588/ijtld.19.0712DOI Listing

Intestinal tuberculosis or Crohn's disease: a review of the diagnostic models designed to differentiate between these two gastrointestinal diseases.

Intest Res 2020 Apr 22. Epub 2020 Apr 22.

Division of Gastroenterology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Differentiating Crohn's disease (CD) from intestinal tuberculosis (ITB) is a diagnostic dilemma, particularly in regions where ITB is prevalent and CD incidence is increasing, because both diseases can present quite similarly, and diagnostic tests to identify Mycobacterium tuberculosis in tissue samples have rather poor sensitivity. Studies that were conducted to determine the factors that differentiate CD from ITB identified some significant characteristics, but none of those characteristics are exclusive to either ITB or CD. Many diagnostic models or scoring systems that use one to several diagnostic parameters have been proposed to help distinguish these two intestinal diseases. Read More

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http://dx.doi.org/10.5217/ir.2019.09142DOI Listing

Gastrointestinal Bleeding in a Patient With Gastric Lymphoma, Tuberculosis Enteritis, and Cytomegalovirus Enteritis.

ACG Case Rep J 2020 Feb 20;7(2):e00317. Epub 2020 Feb 20.

Division of Gastroenterology and Hepatology, Department of Medicine, NYU Langone Medical Center, New York, NY.

Bleeding from the small bowel can be challenging to identify by endoscopic or radiographic evaluation. We present the case of a patient with incompletely treated latent tuberculosis and medical history of T-cell lymphoma who developed gastrointestinal bleeding because of concurrent Burkitt lymphoma, tuberculosis enteritis, and cytomegalovirus enteritis. The interplay of these 3 diagnoses is discussed. Read More

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http://dx.doi.org/10.14309/crj.0000000000000317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145173PMC
February 2020

Imported Infections in Rural Mid-West United States - A Report from a Tertiary Care Center.

Mo Med 2020 Mar-Apr;117(2):89-94

Christian Rojas-Moreno, MD, William Salzer, MD, and Gordon Christensen, MD is in the Department of Medicine, Division of Infectious Diseases, University of Missouri, Columbia, Missouri.

Background: There is lack of specific data on imported infections in the mid-west United States (U.S.). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144708PMC

Misdiagnosis of multiple synchronous small bowel adenocarcinomas as intestinal tuberculosis: a case report.

BMC Gastroenterol 2020 Apr 16;20(1):112. Epub 2020 Apr 16.

Department of Abdominal Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, 200072, China.

Background: Small bowel adenocarcinoma (SBA) is a rare malignancy that primarily occurs in the duodenum. Multiple synchronous SBA is unique rare and difficult to diagnose due to non-specific disease presentation. Protocols to identify multiple synchronous SBA during early disease stages are urgently required. Read More

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http://dx.doi.org/10.1186/s12876-020-01271-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164229PMC

Correction: Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose-response trial.

Food Funct 2020 04;11(4):3751

The College of Public Health, Qingdao University, 38 Dengzhou Road, Qingdao, 266021, Shandong province, China.

Correction for 'Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose-response trial' by Song Lin et al., Food Funct., 2020, 11, 370-377. Read More

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http://dx.doi.org/10.1039/d0fo90017fDOI Listing
April 2020
2.791 Impact Factor

Abdominal tuberculosis in children: A real-world experience of 218 cases from an endemic region.

JGH Open 2020 Apr 20;4(2):215-220. Epub 2019 Aug 20.

Department of Microbiology Post Graduate Institute of Medical Education and Research Chandigarh India.

Background And Aim: Abdominal tuberculosis (ATB) in children poses a diagnostic challenge because of its nonspecific clinical features, which often delay the diagnosis. Our aim was to present our real-world experience and provide an insight into the presentation, pattern of distribution, and diagnosis of the disease.

Methods: A retrospective review was conducted of case records of all children ≤12 years of age diagnosed with ATB from January 2007 to January 2018. Read More

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http://dx.doi.org/10.1002/jgh3.12245DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7144780PMC

Intestinal tuberculosis: Case series of three patients.

Respir Med Case Rep 2020 14;29:100942. Epub 2019 Oct 14.

Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin Makassar, Indonesia.

Background: Intestinal tuberculosis (ITB) is a fraction of extrapulmonary TB, and its diagnosis often pose a significant challenge due to nonspecific presentation. Several methods have been utilized to diagnosed ITB, including findings of specific inflammatory process on histopathological examination. We hereby report three cases of ITB that manifested as caecal and adnexal mass. Read More

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http://dx.doi.org/10.1016/j.rmcr.2019.100942DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7118413PMC
October 2019

Isoniazid Induced Pure Red Blood Cell Aplasia.

Cureus 2020 Feb 27;12(2):e7112. Epub 2020 Feb 27.

Hematology/Oncology, Southern Illinois University School of Medicine, Springfield, USA.

Pure red blood cell aplasia (PRCA) is one of the uncommon causes of anemia. Drug-induced PRCA is even more infrequent. Only a few drugs are implicated in PRCA. Read More

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http://dx.doi.org/10.7759/cureus.7112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7101238PMC
February 2020

Infectious diseases in children and adolescents in China: analysis of national surveillance data from 2008 to 2017.

BMJ 2020 04 2;369:m1043. Epub 2020 Apr 2.

Murdoch Children's Research Institute, Parkville, Victoria, Australia.

Objectives: To outline which infectious diseases in the pre-covid-19 era persist in children and adolescents in China and to describe recent trends and variations by age, sex, season, and province.

Design: National surveillance studies, 2008-17.

Setting: 31 provinces in mainland China. Read More

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http://dx.doi.org/10.1136/bmj.m1043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114954PMC

How can gastro-intestinal tuberculosis diagnosis be improved? A prospective cohort study.

BMC Infect Dis 2020 Mar 30;20(1):255. Epub 2020 Mar 30.

Global and Tropical Health Division, Menzies School of Health Research, Charles Darwin University, Box 41096, Casuarina NT, Darwin, PO, 0811, Australia.

Background: Gastrointestinal tuberculosis (TB) is diagnostically challenging; therefore, many cases are treated presumptively. We aimed to describe features and outcomes of gastrointestinal TB, determine whether a clinical algorithm could distinguish TB from non-TB diagnoses, and calculate accuracy of diagnostic tests.

Methods: We conducted a prospective cohort study of hospitalized patients in Kota Kinabalu, Malaysia, with suspected gastrointestinal TB. Read More

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http://dx.doi.org/10.1186/s12879-020-04983-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106693PMC

'Have we missed reporting adverse drug reactions under Revised National TB Control Programme?' - A mixed method study in Bengaluru, India.

Indian J Tuberc 2020 Jan 15;67(1):20-28. Epub 2020 Jan 15.

ESIC Medical College and PGIMSR, Bengaluru, India.

Objective: Prompt identification, reporting and management of ADRs during anti tuberculosis treatment can ensure better compliance and treatment outcomes. The study was conducted to identify the gaps and associated factors in reporting of ADRs under RNTCP; assess knowledge, attitude and practice of RNTCP staff regarding pharmacovigilance programme and explore the barriers in reporting of ADRs from provider's perspective.

Methods: Mixed method research with sequential explanatory design was carried out in Tuberculosis Units of RNTCP administrative district of Bangalore city during July to December 2017. Read More

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http://dx.doi.org/10.1016/j.ijtb.2020.01.003DOI Listing
January 2020

[Self-reported infections in the German National Cohort (GNC) in the context of the current research landscape].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2020 Apr;63(4):404-414

Abteilung für Epidemiologie, Helmholtz-Zentrum für Infektionsforschung GmbH (HZI), Inhoffenstraße 7, 38124, Braunschweig, Deutschland.

Background: Infectious diseases continue to play an important role for disease perception, health-economic considerations and public health in Germany. In recent years, infectious diseases have been linked to the development of non-communicable diseases. Analyses of the German National Cohort (GNC) may provide deeper insights into this issue and pave the way for new targeted approaches in disease prevention. Read More

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http://dx.doi.org/10.1007/s00103-020-03114-xDOI Listing

Brain abscess in a patient with psoriatic arthritis treated with adalimumab: A case report.

Medicine (Baltimore) 2020 Mar;99(10):e18954

Department of Dermatology, China Medical University Hospital.

Rationale: In patients receiving biological therapies, serious infections are a major concern. Infections associated with anti-tumor necrosis factor antibody therapy include tuberculosis, viral, fungal, and bacterial infections. Likewise, severe infections of the upper and lower respiratory tract, lung, skin and soft tissue, urinary tract, gastrointestinal tract, joint, and bone have also been reported previously. Read More

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http://dx.doi.org/10.1097/MD.0000000000018954DOI Listing

Primary tonsillar tuberculosis: a forgotten clinical identity.

Iran J Microbiol 2019 Dec;11(6):542-545

Department of Pathology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Primary tonsillar tuberculosis is an uncommon entity and a diagnostic challenge. Misdiagnosis can be prevented with early professional para-clinical finding. The true diagnosis is often delayed and infection management depends on recognizing disease patterns and early laboratory documentation. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7048960PMC
December 2019

Behçet's Disease and Tuberculosis: A Complex Relationship.

Eur J Case Rep Intern Med 2020 16;7(2):001354. Epub 2020 Jan 16.

Serviço de Medicina Interna, Hospital Beatriz Ângelo, Loures, Portugal.

Behçet's disease (BD) is a systemic vasculitis characterized by recurrent orogenital ulceration and several systemic manifestations (such as gastrointestinal involvement, vascular disease or arthritis). The pathogenesis is still unknown but the trigger role of certain pathogens such as is well documented. Furthermore, patients with BD are more susceptible to tuberculosis due to immunity defects. Read More

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http://dx.doi.org/10.12890/2020_001354DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7050965PMC
January 2020

Diagnostic reach of gastrointestinal endoscopy: Hypopharyngeal tuberculosis.

Rev Gastroenterol Mex 2020 Feb 29. Epub 2020 Feb 29.

Departamento de Gastroenterología, Hospital Universitario Nacional de Colombia, Bogotá, Colombia.

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http://dx.doi.org/10.1016/j.rgmx.2019.11.004DOI Listing
February 2020

Esophageal tuberculosis complicated with intestinal tuberculosis: A case report.

World J Clin Cases 2020 Feb;8(3):645-651

Department of Gastroenterology, The Second Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.

Background: Although the overall incidence of tuberculosis in underdeveloped areas has increased in recent years, esophageal tuberculosis (ET) is still rare. Intestinal tuberculosis (ITB) is relatively more common, but there are few reports of ET complicated with ITB. We report a case of secondary ET complicated with ITB in a previously healthy patient. Read More

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http://dx.doi.org/10.12998/wjcc.v8.i3.645DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7031823PMC
February 2020

Ultrasound as the first imaging method in severe lung disease. Considerations about a case of pulmonary tuberculosis and review of the literature.

Med Ultrason 2020 03;22(1):102-104

Department of Anatomy, UMF "Iuliu Hatieganu" Cluj-Napoca.

Abdominal ultrasound (US) performed as a "primary imaging procedure" is an important diagnostic tool in gastroenterol-ogy. Expanding the routine investigation to the lower thoracic region might sometimes accelerate the diagnosis in inconclusive manifestations such as pulmonary pathology.US is a valuable tool in evaluating patients with breathing difficulties, chest pain, hypoxia, or chest trauma. Read More

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http://dx.doi.org/10.11152/mu-1890DOI Listing

A colorimetric nanoprobe based on dynamic aggregation of SDS-capped silver nanoparticles for tobramycin determination in exhaled breath condensate.

Mikrochim Acta 2020 02 22;187(3):186. Epub 2020 Feb 22.

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 5165665811, Iran.

A colorimetric nanoprobe was developed for the quantification of tobramycin in exhaled breath condensate (EBC). The nanoprobe consists of silver nanoparticles (Ag NPs) modified with sodium dodecyl sulfate (SDS), which is applied in the presence of sodium metaborate. Characterization of the synthesized SDS-capped Ag NPs by transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), and energy-dispersive X-ray spectroscopy (EDX) showed that the nanoparticles were well synthesized with nearly uniform size and an average diameter of < 30 nm. Read More

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http://dx.doi.org/10.1007/s00604-020-4162-6DOI Listing
February 2020
3.741 Impact Factor

Efficacy of Anti-TNF Therapy for the Treatment of Patients with Moderate-to-Severe Inflammatory Bowel Disease; a First Iranian Report.

Middle East J Dig Dis 2020 Jan;12(1):12-18

Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

BACKGROUND The anti-TNF drugs are shown to be highly effective in treatment of patients with moderate-tosevere inflammatory bowel disease (IBD). Here, we aimed to assess the efficacy and safety of antiTNF therapy at the national level. METHODS IBD patients aged 15 > years who received Infliximab and/or CinnoRA® between 2013 to July 2018 were identified. Read More

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http://dx.doi.org/10.15171/mejdd.2020.158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023648PMC
January 2020

Long-Term Effects of Multi-Drug-Resistant Tuberculosis Treatment on Gut Microbiota and Its Health Consequences.

Front Microbiol 2020 30;11:53. Epub 2020 Jan 30.

Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, China.

Gut microbiota dysbiosis has adverse health effects on human body. Multi-drug-resistant tuberculosis (MDR-TB) treatment uses a variety of antibiotics typically for more than 20 months, which may induce gut microbiota dysbiosis. The aim of this study is to investigate the long-term effects of MDR-TB treatment on human gut microbiota and its related health consequences. Read More

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http://dx.doi.org/10.3389/fmicb.2020.00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7002438PMC
January 2020
3.941 Impact Factor