279,121 results match your criteria Tuberculosis


Are we ready with fluroquinolone based treatment regimen for drug resistance tuberculosis in a resource limited country?

Indian J Tuberc 2022 Jul 29;69(3):374-375. Epub 2022 Apr 29.

Department of Pulmonary Medicine, AIIMS, Patna, 801505, India.

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Comparison of performance indicators of MGIT primary culture to assess the impact of implementation of ISO 15189:2012 standards.

Indian J Tuberc 2022 Jul 1;69(3):371-373. Epub 2022 Apr 1.

ICMR-National Institute for Research in Tuberculosis, Chennai, India. Electronic address:

Performance indicators are key component and plays a major role for monitoring and continuous quality improvement of the test results. The NABL certificate of accreditation is issued in accordance with the standard ISO 15189:2012 requirements. As part of the accreditation process, the laboratory has acquired knowledge and implemented the quality system procedures. Read More

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Indeterminate mycobacterium tuberculosis QuantiFERON post Moderna mRNA Covid-19 vaccination.

Authors:
Samuel S Y Wang

Indian J Tuberc 2022 Jul 31;69(3):369-370. Epub 2022 Mar 31.

Tuberculosis Control Unit, Tan Tock Seng Hospital, Singapore, Singapore. Electronic address:

We report an interesting case of an indeterminate MTB QuantiFERON for a 26-year-old healthy soldier planned for a routine field exercise to Brunei. Further medical history revealed that the patient had a Moderna mRNA Covid-19 vaccine the day before his MTB QuantiFERON test. The patient was subsequently asked to repeat a T-spot test which was non-reactive, there were no longer any issues with the positive control for the T-spot test. Read More

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Effect of COVID-19 pandemic on tuberculosis notification.

Indian J Tuberc 2022 Jul 12;69(3):364-365. Epub 2021 Aug 12.

Department of Pulmonary and Critical Care Medicine, VMMC & Safdarjung Hospital, New Delhi 110029, India. Electronic address:

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An unusual site of articular tuberculosis-A series of three conservatively managed cases.

Indian J Tuberc 2022 Jul 13;69(3):359-363. Epub 2021 Jul 13.

Department of Pulmonary Medicine, Government Medical College, Patiala, India. Electronic address:

Tuberculosis (TB) infection of the Sternoclavicular joint (SCJ) is a rare entity, with 1-2% of all osteo-articular cases reported. We report a series of three cases of TB of the SCJ, in the patients presented with swelling of SCJ. Cytology showed chronic granulomatous pathology in all three cases, with one patient having Cartridge base nucleic acid amplification test positive for TB and another one having acid fast bacilli positive on Ziehl Neelsen staining. Read More

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Ruxolitinib and tuberculosis: A case report with brief review.

Indian J Tuberc 2022 Jul 26;69(3):354-358. Epub 2021 Jun 26.

Department of Clinical Hematology, King George's Medical University, Lucknow, India.

JAK 2 inhibitors are widely used for the treatment of primary myelofibrosis. Ruxolitinib is the most commonly used JAK inhibitor in clinical practice. We report two cases of Primary Myelofibrosis who developed tuberculosis on active treatment with ruxolitinib. Read More

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Health-related quality of life of multidrug-resistant tuberculosis patients: A study of eastern Uttar Pradesh, India.

Indian J Tuberc 2022 Jul 15;69(3):347-353. Epub 2021 Jun 15.

Department of Paediatric and Preventive Dentistry, Faculty of Dental Sciences, King George Medical University, Lucknow, India.

Introduction: Much attention has been given to the microbiological aspect, drug treatment, and clinical indicators of MDR-TB, but patients' QOL has remained a neglected area. In this study, we aimed to find the quality of MDRTB on various quality of life domains during the initiation of the MDR Treatment regimen.

Materials & Methods: A cross-sectional study was conducted over a period of 6 months at the Drug-Resistance Tuberculosis Management Centre (DR-TB Centre), of a tertiary care centre in the eastern Uttar pradesh, India. Read More

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A prospective observational study to evaluate Glutathione S-transferase gene polymorphism and its association with Antitubercular drugs induced liver injury in tertiary hospital.

Indian J Tuberc 2022 Jul 15;69(3):341-346. Epub 2021 Jun 15.

Department of Pharmacology & Therapeutics, King George Medical University, Lucknow, U.P, India. Electronic address:

Background: Anti-TB drugs are most common cause of idiosyncratic hepatotoxicity worldwide. Reactive metabolite formed during drug metabolism has been involved in a clinical toxicity are described as 'idiosyncratic' drug induce liver injury (DILI). We have observed the distribution of glutathione S -transferase (GST) gene polymorphism & its association with drug-induced liver injury in patients taking anti-tubercular treatment. Read More

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Treatment adherence status of the TB patients notified from private sector and its associated factors: Findings of a secondary data analysis from West Bengal, India.

Indian J Tuberc 2022 Jul 16;69(3):334-340. Epub 2021 Jun 16.

Hony. Secretary, Health Vision Research, Jessore Road, Kolkata, 700089, India.

Introduction: In India, each year, estimated one million TB cases are missing from notification, most of them being diagnosed treated in private sector. The large number of patients in private sector has raised concerns about suboptimal quality of care; lack of systems for treatment adherence thus raising the risk of drug resistance. The current analysis was conducted to find out the status of TB treatment adherence in private sector & to identify the factors associated with poor TB treatment adherence. Read More

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Cyclophosphamide therapy as an adjunct in refractory post-tubercular arachnoiditis.

Indian J Tuberc 2022 Jul 29;69(3):325-333. Epub 2021 May 29.

Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.

Introduction: There is no satisfactory treatment for post tubercular arachnoiditis (TB arachnoiditis). We did this study to investigate the efficacy and safety of cyclophosphamide as adjuvant therapy for post TB arachnoiditis refractory to corticosteroids and anti-tubercular therapy (ATT).

Methods: This was a retrospective case series of patients of refractory post TB arachnoiditis leading to paraparesis and vision loss who received cyclophosphamide as an adjuvant therapy along with standard ATT and corticosteroids. Read More

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Implementation of revised national tuberculosis control program guidelines: Practitioner's perspective and awareness-a questionnaire based study.

Indian J Tuberc 2022 Jul 20;69(3):320-324. Epub 2021 Apr 20.

Department of Pharmacology, Fr Muller Medical College Kankanady, Mangalore, India. Electronic address:

Background: Strengthening public health services, setting up directly observed therapy short course Centres, introduction of Revised National tuberculosis Control Program (RNTCP) are aimed to eradicate tuberculosis by 2025. The aim of this study was to assess physician's awareness, and perspectives about the recent RNTCP guidelines.

Methods: This was a cross-sectional, opinion deriving, study through a tested, validated, standardized questionnaire that covered the role of physician in the diagnosis or treatment of tuberculosis, and tested their awareness about various aspects of RNTCP guidelines. Read More

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Plasma drug concentrations of 4-drug fixed-dose combination regimen and its efficacy for treatment of pulmonary tuberculosis under National Tuberculosis Elimination Programme: A prospective pilot study.

Indian J Tuberc 2022 Jul 20;69(3):311-319. Epub 2021 Apr 20.

Department of Clinical Pharmacy, Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Pune, Maharashtra, 411038, India. Electronic address:

Background: The thrice weekly dosing regimen of DOTS has shown low rifampicin plasma concentrations as an independent risk factor for unfavourable tuberculosis (TB) outcome. With introduction of daily regimen using fixed dose combinations (FDC) under National Tuberculosis Elimination Programme (NTEP) the existence of suboptimal plasma levels of first-line antitubercular drugs and its clinical significance remain poorly understood.

Method: We included a prospective cohort of newly diagnosed pulmonary tuberculosis (PTB) patients receiving 4-FDC daily regimen under NTEP. Read More

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Obstetrics outcome in pulmonary tuberculosis.

Indian J Tuberc 2022 Jul 7;69(3):305-310. Epub 2021 Jan 7.

Department of Obstetrics and Gynecology, AIIMS, New Delhi, India.

Background: To evaluate the maternal and perinatal outcome in pulmonary tuberculosis cases as compared to low risk pregnancies in a tertiary referral hospital.

Methods: A total of 15 cases of pulmonary tuberculosis over a period of two years who delivered in our unit was studied in the retrospective study. The maternal and perinatal outcome in them was compared with 191 low risk pregnancies who delivered at the same time in the hospital after taking into account inclusion and exclusion criteria. Read More

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Recent updates in natural terpenoids as potential anti-mycobacterial agents.

Indian J Tuberc 2022 Jul 15;69(3):282-304. Epub 2021 Jul 15.

Division of Bioinformatics, Department of Pharmaceutical Chemistry, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur, District Dhule, Maharashtra, 425 405, India. Electronic address:

Tuberculosis is considered as a leading health issue globally. Even though, the todays first line anti-mycobacterial treatments used in the hospital have low deaths, multidrug-resistance forms of the ailment have now spread globally and become a major issue. The wide-ranging biodiversity of medicinal plants, ocean animals have gained considerable attention for drug discovery in previous spans, and the emergence of TB drug resistance has inspired interest in judging natural products (NPs) to cure this disease. Read More

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Review on public private mix TB control strategy in India.

Indian J Tuberc 2022 Jul 15;69(3):277-281. Epub 2021 Jul 15.

KSPH, KIIT University, Bhubaneswar, Odisha, India.

In India, around 70% of health care services are offered by the private sector. National strategic plan (NSP) has emphasized private sector engagement to TB program. Public private mix strategy along with web based mandatory notification of TB cases were established in 2002. Read More

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Rectal tuberculosis: A systematic review.

Indian J Tuberc 2022 Jul 16;69(3):268-276. Epub 2021 Jun 16.

Department of General Surgery, Lady Hardinge Medical College, Dr Ram Manohar Lohia Hospital, New Delhi, India.

Rectal tuberculosis is an uncommon entity. It has unique epidemiological features, specific medical treatment and surgery is rarely indicated. The first case of rectal tuberculosis was reported in 1957. Read More

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Recent updates in diagnosis and management of drug-resistant tuberculosis in India: A paradigm shift and the way ahead during the COVID-19 crisis.

Indian J Tuberc 2022 Jul 16;69(3):264-267. Epub 2021 Aug 16.

Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, New Delhi, India.

The recent guidelines on the Programmatic Management of Drug-Resistant Tuberculosis (DR-TB) in India (PMDT) have been released in March 2021 on World TB Day. The new guidelines have considered emerging diagnostic trends including TrueNat, Xpert Mtb/XDR, Next generation sequencing and evaluation for resistance to newer drugs including Bedaquiline (Bdq) and Delamanid. The emerging therapeutic trends include focus on oral shorter Bdq based regimen with phasing out injectables use. Read More

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Towards building a tuberculosis free world.

Authors:
Sudarsan Mandal

Indian J Tuberc 2022 Jul 17;69(3):259-261. Epub 2021 Aug 17.

Central TB Division, Room No. 532 'C' Wing, Nirman Bhawan, Ministry of Health & Family Welfare, Govt. of India, Maulana Azad Road, New Delhi 110011, India. Electronic address:

The Honourable Prime Minister of India set a target of year 2025 for elimination of TB from the country, 5 years ahead of the Sustainable Development Goal of 2030. Last few years, India has made significant improvements, towards elimination of tuberculosis from the country in the form of bold policies and unprecedented political commitment. While COVID-19 has resulted in setbacks for TB elimination efforts, it has also offered an opportunity to revisit and structurally redesign the public health infrastructure/system in our country. Read More

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Detection of M. tuberculosis in the environment as a tool for identifying high-risk locations for tuberculosis transmission.

Sci Total Environ 2022 Jun 24:156970. Epub 2022 Jun 24.

Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Tuberculosis (TB) remains a leading cause of infectious mortality globally, yet most cases cannot be epidemiologically linked even with extensive contact investigations and whole genome sequencing. Consequently, there remain major gaps in our understanding of where and when M. tuberculosis (Mtb) exposures occur. Read More

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Review: Liposomes in the prophylaxis and treatment of infectious diseases.

Life Sci 2022 Jun 24:120734. Epub 2022 Jun 24.

Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia. Electronic address:

Infectious diseases remain as one of the major burdens among health communities as well as in the general public despite the advances in prevention and treatment. Although vaccination and vector eliminations have greatly prevented the transmission of these diseases, the effectiveness of these strategies is no longer guaranteed as new challenges such as drug resistance and toxicity as well as the missing effective therapeutics arise. Hence, the development of new tools to manage these challenges is anticipated, in which nano technology using liposomes as effective nanostructure is highly considered. Read More

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Diagnosing Tuberculosis: What Do New Technologies Allow Us to (Not) Do?

Respiration 2022 Jun 27:1-17. Epub 2022 Jun 27.

DSI-NRF Centre of Excellence for Biomedical Tuberculosis Research, South African Medical Research Council Centre for Tuberculosis Research, Division of Molecular Biology and Human Genetics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

New tuberculosis (TB) diagnostics are at a crossroads: their development, evaluation, and implementation is severely damaged by resource diversion due to COVID-19. Yet several technologies, especially those with potential for non-invasive non-sputum-based testing, hold promise for efficiently triaging and rapidly confirming TB near point-of-care. Such tests are, however, progressing through the pipeline slowly and will take years to reach patients and health workers. Read More

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Designing quinoline-isoniazid hybrids as potent anti-tubercular agents inhibiting mycolic acid biosynthesis.

Eur J Med Chem 2022 Jun 17;239:114531. Epub 2022 Jun 17.

Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, 1919 route de Mende, 34293, Montpellier, France; INSERM, IRIM, 34293, Montpellier, France. Electronic address:

Isoniazid is a cornerstone of modern tuberculosis (TB) therapy and targets the enoyl ACP reductase InhA, a key enzyme in mycolic acid biosynthesis. InhA is still a promising target for the development of new anti-TB drugs. Herein, we report the design, synthesis, and anti-tubercular activity of new isoniazid hybrids. Read More

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A rare case of calvarial tuberculosis from the Avar Age (8th century CE) cemetery of Kaba-Bitózug (Hajdú-Bihar county, Hungary) - Pathogenesis and differential diagnostic aspects.

Tuberculosis (Edinb) 2022 Jun 21;135:102226. Epub 2022 Jun 21.

Department of Biological Anthropology, Institute of Biology, University of Szeged, Közép fasor 52, H-6726, Szeged, Hungary; Department of Archaeogenetics, Institute of Hungarian Research, Úri utca 54-56, H-1014, Budapest, Hungary. Electronic address:

The aim of our paper is to present and discuss in detail the bony changes indicative of tuberculosis (TB) that were identified in a skeleton (KB67), unearthed from grave 67 of the 8th-century-CE cemetery of Kaba-Bitózug (Hungary). Furthermore, to provide the differential diagnoses of the observed alterations, with special attention to the cranial osteolytic lesions. During the macro- and micromorphological examinations of KB67, the skull revealed three small, well-circumscribed, punched-out osteolytic lesions accompanied by endocranial granular impressions, abnormal blood vessel impressions, periosteal appositions, and cortical erosion. Read More

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Plasma cytokine levels characterize disease pathogenesis and treatment response in tuberculosis patients.

Infection 2022 Jun 27. Epub 2022 Jun 27.

Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine University, 40225, Duesseldorf, Germany.

Background: Mycobacterium (M.) tuberculosis-caused immunopathology is characterized by aberrant expression of plasma cytokines in human tuberculosis. Disease severity and long-term anti-mycobacterial treatment are potentially influenced by immunopathology and normalization of plasma cytokine levels during therapy may indicate treatment efficacy and recovery. Read More

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Noninvasive respiratory support in intensive care medicine.

Intensive Care Med 2022 Jun 27. Epub 2022 Jun 27.

Keenan Research Centre, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, ON, Canada.

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Immunogenicity and Safety of SpikoGen®, an Adjuvanted Recombinant SARS-CoV-2 Spike Protein vaccine as a Homologous and Heterologous Booster Vaccination: A Randomized Placebo-Controlled Trial.

Immunology 2022 Jun 27. Epub 2022 Jun 27.

Medical Department, Orchid Pharmed Company, Tehran, Iran.

SpikoGen® is a subunit recombinant spike protein vaccine combined with Advax-CpG55.2™ adjuvant. This COVID-19 vaccine was shown to be safe, immunogenic, and efficacious in previous clinical trials. Read More

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Variants in Bedaquiline-Candidate-Resistance Genes: Prevalence in Bedaquiline-Naive Patients, Effect on MIC, and Association with Mycobacterium tuberculosis Lineage.

Antimicrob Agents Chemother 2022 Jun 27:e0032222. Epub 2022 Jun 27.

Tuberculosis Omics Research Consortium, Family Medicine and Population Health, Faculty of Medicine and Health Sciences, University of Antwerpgrid.5284.b, Antwerp, Belgium.

Studies have shown that variants in bedaquiline-resistance genes can occur in isolates from bedaquiline-naive patients. We assessed the prevalence of variants in all bedaquiline-candidate-resistance genes in bedaquiline-naive patients, investigated the association between these variants and lineage, and the effect on phenotype. We used whole-genome sequencing to identify variants in bedaquiline-resistance genes in isolates from 509 bedaquiline treatment naive South African tuberculosis patients. Read More

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Accuracy of Tongue Swab Testing Using Xpert MTB-RIF Ultra for Tuberculosis Diagnosis.

J Clin Microbiol 2022 Jun 27:e0042122. Epub 2022 Jun 27.

Uganda Tuberculosis Implementation Research Consortium, Kampala, Uganda.

Tongue dorsum swabs have shown promise as alternatives to sputum for detecting Mycobacterium tuberculosis (MTB) in patients with pulmonary tuberculosis (TB). Some of the most encouraging results have come from studies that used manual quantitative PCR (qPCR) to analyze swabs. Studies using the automated Cepheid Xpert MTB/RIF Ultra qPCR test (Xpert Ultra) have exhibited less sensitivity with tongue swabs, possibly because Xpert Ultra is optimized for testing sputum, not tongue swab samples. Read More

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Production and Purification of Phosphatidylinositol Mannosides from Mycobacterium smegmatis Biomass.

Curr Protoc 2022 Jun;2(6):e458

Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Universidade Nova de Lisboa, Oeiras, Portugal.

Mycobacterium tuberculosis, the etiological agent of tuberculosis, is regarded as the most successful pathogen of humankind and a major threat to global health. The mycobacterial cell wall is vital for cell growth, virulence, and resistance to antibiotics, and thus constitutes a unique target for drug development. To characterize the enzymes catalyzing the synthesis of the cell wall components, considerable amounts of substrates are required. Read More

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IMPACT OF NUTRITIONAL CORRECTION OF PROTEIN METABOLISM DISORDERS ON THE CLINICAL COURSE OF PULMONARY TUBERCULOSIS.

Wiad Lek 2022 ;75(5 pt 1):1077-1082

UKRAINIAN MILITARY MEDICAL ACADEMY, KYIV, UKRAINE.

Objective: The aim: To study the impact of nutritional correction of protein metabolism disorders on the clinical course of pulmonary tuberculosis.

Patients And Methods: Materials and methods: The study involved 67 patients with pulmonary tuberculosis, which were divided into two groups: group I - 35 patients who underwent nutritional correction of protein metabolism disorders against the background of antimycobacterial therapy (AMBT) and group II - 32 patients who received standard AMBT. An assessment of clinical indicators and the condition of protein metabolism (PM) was conducted by determining the concentration of individual non-essential, essential amino acids and their total amount. Read More

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January 2022