251,558 results match your criteria Tuberculosis


Pharmacokinetics of dolutegravir 100 mg once-daily with rifampicin.

Int J Antimicrob Agents 2019 Apr 16. Epub 2019 Apr 16.

Jefferiss Research Trust Laboratories, Department of Medicine, Imperial College London, London, UK; St. Stephen's Centre, Chelsea and Westminster Hospital, London, UK.

Background: Tuberculosis (TB) causes 25% of all deaths among HIV-infected individuals. Rifampicin (RIF) is a potent inducer of drug metabolising enzymes and drug transporters and co-administration with dolutegravir (DTG) reduces DTG exposure, which can be overcome by doubling the DTG dose to 50 mg twice-daily. We investigated the effect of RIF on the DTG exposure when dosed at 100 mg once-daily, which could provide an easier option than 50 mg twice-daily. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09248579193009
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http://dx.doi.org/10.1016/j.ijantimicag.2019.04.009DOI Listing
April 2019
1 Read

Restoration of cytosolic calcium inhibits Mycobacterium tuberculosis intracellular growth: theoretical evidence and experimental observation.

J Theor Biol 2019 Apr 16. Epub 2019 Apr 16.

Drug Discovery Research Centre, Translational Health Science and Technology Institute, NCR Biotech Science Cluster, Faridabad 121001, India. Electronic address:

Mycobacterium tuberculosis (Mtb) is a highly successful intracellular pathogen because of its ability to modulate host's anti-microbial pathways. Phagocytosis acts as the first line of defence against microbial infection. However, Mtb inhibits Phosphatidylinositol 3-phosphate (PI3P) oscillations which is required for phagolysosomal fusion. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.017DOI Listing

Biophysical characterization of mycobacterial model membranes and their interaction with rifabutin: Towards lipid-guided drug screening in tuberculosis.

Biochim Biophys Acta Biomembr 2019 Apr 16. Epub 2019 Apr 16.

Department of Chemistry, Indian Institute of Technology (IIT) Bombay, Mumbai, Maharashtra 400076, India. Electronic address:

Lipid structure critically dictates the molecular interactions of drugs with membranes influencing passive diffusion, drug partitioning and accumulation, thereby underpinning a lipid-composition specific interplay. Spurring selective passive drug diffusion and uptake through membranes is an obvious solution to combat growing antibiotic resistance with minimized toxicities. However, the spectrum of complex mycobacterial lipids and lack thereof of suitable membrane platforms limits the understanding of mechanisms underlying drug-membrane interactions in tuberculosis. Read More

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http://dx.doi.org/10.1016/j.bbamem.2019.04.004DOI Listing

Survival of Mycobacterium bovis BCG oral vaccine during transit through a dynamic in vitro model simulating the upper gastrointestinal tract of badgers.

PLoS One 2019 19;14(4):e0214859. Epub 2019 Apr 19.

Department of Bacteriology, Animal and Plant Health Agency, New Haw, Addlestone, United Kingdom.

In developing an oral bait BCG vaccine against tuberculosis in badgers we wanted to understand the conditions of the gastrointestinal tract and their impact on vaccine viability. Conditions mimicking stomach and small-intestine caused substantial reduction in BCG viability. We performed in vivo experiments using a telemetric pH monitoring system and used the data to parameterise a dynamic in vitro system (TIM-1) of the stomach and small intestine. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214859PLOS

Structure-Guided Drug Design of 6-Substituted Adenosine Analogues as Potent Inhibitors of Mycobacterium tuberculosis Adenosine Kinase.

J Med Chem 2019 Apr 19. Epub 2019 Apr 19.

Department of Biochemistry and Biophysics , Texas A&M University , College Station , Texas 77843 , United States.

Mycobacterium tuberculosis adenosine kinase (MtbAdoK) is an essential enzyme of Mtb and forms part of the purine salvage pathway within mycobacteria. Evidence suggests that the purine salvage pathway might play a crucial role in Mtb survival and persistence during its latent phase of infection. In these studies, we adopted a structural approach to the discovery, structure-guided design, and synthesis of a series of adenosine analogues that displayed inhibition constants ranging from 5 to 120 nM against the enzyme. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.9b00020DOI Listing

What is your diagnosis? A shoulder mass in a great horned owl.

Vet Clin Pathol 2019 Apr 19. Epub 2019 Apr 19.

Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada.

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http://dx.doi.org/10.1111/vcp.12738DOI Listing

Outcomes of Bedaquiline Treatment in Patients with Multidrug-Resistant Tuberculosis.

Emerg Infect Dis 2019 May;25(5):936-943

Bedaquiline is recommended by the World Health Organization for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB). We pooled data from 5 cohorts of patients treated with bedaquiline in France, Georgia, Armenia, and South Africa and in a multicountry study. The rate of culture conversion to negative at 6 months (by the end of 6 months of treatment) was 78% (95% CI 73. Read More

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http://wwwnc.cdc.gov/eid/article/25/5/18-1823_article.htm
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http://dx.doi.org/10.3201/eid2505.181823DOI Listing
May 2019
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Outbreak of Nontuberculous Mycobacteria Joint Prosthesis Infections, Oregon, USA, 2010-2016.

Emerg Infect Dis 2019 May;25(5):849-855

We investigated a cluster of Mycobacterium fortuitum and M. goodii prosthetic joint surgical site infections occurring during 2010-2014. Cases were defined as culture-positive nontuberculous mycobacteria surgical site infections that had occurred within 1 year of joint replacement surgery performed on or after October 1, 2010. Read More

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http://dx.doi.org/10.3201/eid2505.181687DOI Listing

Mixed Mycobacterium tuberculosis Lineage Infection in 2 Elephants, Nepal.

Emerg Infect Dis 2019 May;25(5):1031-1032

Tuberculosis in elephants is primarily caused by Mycobacterium tuberculosis. We identified mixed M. tuberculosis lineage infection in 2 captive elephants in Nepal by using spoligotyping and large sequence polymorphism. Read More

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http://dx.doi.org/10.3201/eid2505.181898DOI Listing

Mycobacterium obuense Bacteremia in a Patient with Pneumonia.

Emerg Infect Dis 2019 May;25(5):1015-1016

Mycobacterium obuense is a pigmented, rapidly growing mycobacterium. Because it has been considered nonpathogenic, M. obuense is being investigated in clinical trials of cancer immunotherapy and bioremediation. Read More

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http://dx.doi.org/10.3201/eid2505.180208DOI Listing

Transmitted HIV-1 drug resistance in a treatment naïve cohort of recently infected individuals from Chennai, India.

AIDS Res Hum Retroviruses 2019 Apr 19. Epub 2019 Apr 19.

National Institute for Research in Tuberculosis, HIV/AIDS, Chennai, Tamil Nadu, India ;

A cross sectional study was undertaken to examine the prevalence and pattern of HIV drug resistance mutations among recently HIV-1 infected and antiretroviral therapy-naïve individuals from Chennai, South India. The HIV-1 Pol gene encompassing the Protease and Reverse Transcriptase (RT) regions were analysed from 53 ART -naïve HIV-1 infected individuals using an in-house method for identifying drug resistance mutations by genotyping. The overall prevalence of transmitted drug resistance (TDR) was found to be 11. Read More

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http://dx.doi.org/10.1089/AID.2019.0022DOI Listing

[Preparation of multi-epitope recombinant diagnostic antigen of Mycobacterium tuberculosis].

Authors:
Jian Gao Ding Zhao

Sheng Wu Gong Cheng Xue Bao 2019 Apr;35(4):718-725

Department of Laboratory Medicine, Children's Hospital Affiliated of Zhengzhou University, Zhengzhou 450000, Henan, China.

Multi-epitope recombinant diagnostic antigen (designated 'B102') of Mycobacterium tuberculosis (Mtb) was prepared and evaluated as a serological diagnostic antigen. With TRX at the N-terminal and His tag at the C-terminal, the multi-epitope Mtb recombinant diagnostic antigen including 11 predicted B-cell epitopes from 6 Mtb antigens (PstS1, ESAT6, CFP10, Ag85B, Ag85A and PPE54) was expressed in Escherichia coli BL21 (DE3) and purified by Ni²⁺-Chelating affinity and DEAE anion exchange chromatography. Based on the antigenicity of B102 confirmed in Western blotting analysis, we constructed and evaluated a double-antigen sandwich ELISA for diagnosis of Mtb infection. Read More

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http://www.cnki.net/kcms/doi/10.13345/j.cjb.180392.html
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http://dx.doi.org/10.13345/j.cjb.180392DOI Listing
April 2019
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Circulating free DNA concentration as a marker of disease recurrence and metastatic potential in lung cancer.

Clin Transl Med 2019 Apr 18;8(1):14. Epub 2019 Apr 18.

Department of Medical Genetics, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Background: Plasma circulating cell-free (cf) DNA is regarded as a source of tumor DNA. Based on availability of blood tissue for the purposes of early detection of cancer and patients' follow-up, several studies have evaluated concentration of cf DNA in cancer patients in association with tumor features. In the present study, we assessed concentration of cf DNA in lung cancer patients with two commercial kits (MN and QIAGEN) to find whether it can be used as a prognostic biomarker. Read More

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https://clintransmed.springeropen.com/articles/10.1186/s4016
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http://dx.doi.org/10.1186/s40169-019-0229-6DOI Listing
April 2019
1 Read

Rv1075c of Mycobacterium tuberculosis is a GDSL-Like Esterase and is Important for Intracellular Survival.

J Infect Dis 2019 Apr 18. Epub 2019 Apr 18.

Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center, Memphis, TN.

Mycobacterium tuberculosis (Mtb) lipid metabolism pathways facilitate access to carbon and energy sources for Mtb during infection. A Mtb gene, Rv1075c, was annotated as a conserved hypothetical protein. We have identified that Rv1075c amino acid sequence shares similarities to other bacterial lipase/esterases. Read More

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http://dx.doi.org/10.1093/infdis/jiz169DOI Listing

The Gut Microbiome Signatures Discriminate Healthy From Pulmonary Tuberculosis Patients.

Front Cell Infect Microbiol 2019 3;9:90. Epub 2019 Apr 3.

Translational Medicine Research Center, Beijing Chest Hospital, Capital Medical University, Beijing, China.

Cross talk occurs between the human gut and the lung through a gut-lung axis involving the gut microbiota. However, the signatures of the human gut microbiota after active infection have not been fully understood. Here, we investigated changes in the gut microbiota in tuberculosis (TB) patients by shotgun sequencing the gut microbiomes of 31 healthy controls and 46 patients. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00090
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http://dx.doi.org/10.3389/fcimb.2019.00090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456665PMC
April 2019
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Comparison of Serum Potassium, MagnEsium, and Calcium Levels between Kanamycin and Capreomycin-BASEd Regimen-Treated MultiDrug-Resistant TuBerculosis Patients in Bandung (CEASE MDR-TB): A Retrospective Cohort Study.

Int J Microbiol 2019 14;2019:5065847. Epub 2019 Mar 14.

Clinical Pathology Department, Hasan Sadikin General Hospital/Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.

Treatment of multidrug-resistant tuberculosis (MDR-TB) with second-line injectable drugs may result in an electrolyte imbalance. This retrospective study was performed to compare and evaluate the effect of kanamycin and capreomycin on serum potassium, calcium, and magnesium in the first and second month treatment at a tertiary, top-referral hospital in Bandung, Indonesia. Data from 84 subjects with complete medical records of at least serum potassium during either kanamycin-based or capreomycin-based treatment were retrieved from the institutional database. Read More

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http://dx.doi.org/10.1155/2019/5065847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437726PMC

Concurrent Spinal Epidural Tubercular and Pyogenic Abscess of Cervical Spine without Bony Involvement.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):374-378

Department of Neurosurgery, L.T.M.G. Hospital, Mumbai, Maharashtra, India.

Spinal epidural abscess (SEA) presents with vertebral body involvement. SEA is mostly pyogenic in developed countries, but in developing countries, tuberculosis is more common cause. Young female presented with fever, neck, and right upper limb pain for 1 month followed by acute onset weakness in the right upper limb. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_318_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454951PMC

Tuberculosis: A Common Infection with Rare Presentation, Isolated Sellar Tuberculoma with Panhypopituitarism.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):327-330

Department of Neurosurgery, Superspeciality Hospital and Government Medical College, Nagpur, Maharashtra, India.

Isolated sellar tuberculoma is a very rare condition and usually presents with headache and decreased vision. It can present with panhypopituitarism with 3 nerve palsy. Tuberculoma mimics pituitary adenoma clinically as well as radiologically and requires endoscopic transsphenoidal surgery and histopathological examination for the final diagnosis. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_332_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454932PMC

Standalone Instrumented Posterior Approach Used as Universal Approach for Tuberculosis Spondylodiscitis.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):225-233

Department of Neurosurgery, AIIMS, Bhubaneswar, Odisha, India.

Background: Surgical management of spinal tuberculosis (TB) has been classically the anterior, then combined, and of late increasingly by the posterior approach. The posterior approach has been successful in early disease. There has been a paradigm shift and inquisitive to explore this approach in the more advanced and even long-segment disease. Read More

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http://dx.doi.org/10.4103/jnrp.jnrp_294_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454971PMC

Tuberculosis in Pregnancy - a Summary.

Geburtshilfe Frauenheilkd 2019 Apr 8;79(4):358-365. Epub 2019 Jan 8.

Abteilung für Geburtsmedizin, Universitätsfrauenklinik Leipzig, Universitätsklinikum Leipzig AöR, Leipzig, Germany.

In recent years, the incidence of tuberculosis in pregnancy in the industrialised countries has increased. Tuberculosis in pregnancy is associated with an increased risk for the mother and child. Even if no figures are available for Germany, an increase in the number of tuberculosis cases among pregnant women can be assumed due to the migratory flows; current data from the USA, for example, also show an increasing incidence of tuberculosis in pregnant women in recent years. Read More

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http://dx.doi.org/10.1055/a-0774-7924DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461468PMC

Raised levels of IFN-gamma and IL-13 are associated with pre-diabetes amongst newly diagnosed patients with Tuberculosis.

J Pak Med Assoc 2019 Apr;69(4):468-473

Indus Hospital, Karachi.

Objective: To investigate pre-diabetes and diabetes in newly-diagnosed tuberculosis patients and to assess the association of serum cytokine levels with diabetes status.

Methods: The cross-sectional study was conducted at Indus Hospital and The Aga Khan University Hospital, Karachi from May to November 2015, and included patients of either gender aged 18 years or more with a confirmed diagnosis of tuberculosis who were either newly diagnosed or had received up to 1 month of anti-tuberculosis therapy were included. Patients were enrolled from among those presenting to the clinics at Indus Hospital, Karachi, and the Department of Medicine, Aga Khan University Hospital (AKUH), Karachi. Read More

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April 2019
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Efficient Deep Network Architectures for Fast Chest X-Ray Tuberculosis Screening and Visualization.

Sci Rep 2019 Apr 18;9(1):6268. Epub 2019 Apr 18.

Department of Diagnostic and Interventional Radiology, Klinikum rechts der Isar, Technical University of Munich, 81675, München, Germany.

Automated diagnosis of tuberculosis (TB) from chest X-Rays (CXR) has been tackled with either hand-crafted algorithms or machine learning approaches such as support vector machines (SVMs) and convolutional neural networks (CNNs). Most deep neural network applied to the task of tuberculosis diagnosis have been adapted from natural image classification. These models have a large number of parameters as well as high hardware requirements, which makes them prone to overfitting and harder to deploy in mobile settings. Read More

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http://www.nature.com/articles/s41598-019-42557-4
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http://dx.doi.org/10.1038/s41598-019-42557-4DOI Listing
April 2019
1 Read

A Genome-Wide Association Study implicates in Lymphangioleiomyomatosis Pathogenesis.

Eur Respir J 2019 Apr 18. Epub 2019 Apr 18.

Division of Pulmonary and Critical Care Medicine and of Genetics, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

Rationale: Lymphangioleiomyomatosis occurs either associated with Tuberous Sclerosis Complex or as sporadic disease (S-LAM). Risk factors for development of S-LAM are unknown.

Objectives: We hypothesised that DNA sequence variants outside of / might be associated with susceptibility for S-LAM, and performed a Genome Wide Association Study (GWAS). Read More

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http://dx.doi.org/10.1183/13993003.00329-2019DOI Listing

Protecting those who serve: are we doing enough to prevent tuberculosis in healthcare workers?

Eur Respir J 2019 Apr 18;53(4). Epub 2019 Apr 18.

Dept of Medical, Surgical and Experimental Sciences, Clinical Epidemiology and Medical Statistics Unit, University of Sassari, Sassari, Italy

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http://dx.doi.org/10.1183/13993003.00485-2019DOI Listing

Raw starch microparticles as BCG adjuvant: Their efficacy depends on the virulence of the infection strains.

Vaccine 2019 Apr 15. Epub 2019 Apr 15.

Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México (UNAM), A.P. 70228, Ciudad Universitaria, Ciudad de México 04510, Mexico. Electronic address:

The persistence of tuberculosis (TB) as one of the top 10 causes of death worldwide, the growing incidence of multidrug-resistant tuberculosis and the controversial efficacy of the Bacille Calmette-Guérin (BCG) vaccine drives the development of new generation multistage vaccines against this disease that can boost BCG-primed immunity. The use of polymeric microparticles for this purpose increases due to their advantages, especially their good safety levels and intrinsic immunostimulant properties. We recently explored and demonstrated the reinforcing and adjuvant potential of starch microparticles (SMPs) that administered intranasally to BCG-primed BALB/c mice, alone or in combination with a recombinant antigen, increased survival rates and induced a reduction of bacterial load in the lungs of mice infected with tuberculosis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193047
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http://dx.doi.org/10.1016/j.vaccine.2019.04.027DOI Listing
April 2019
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Identification of a novel carboxypeptidase encoded by Rv3627c that plays a potential role in mycobacteria morphology and cell division.

Enzyme Microb Technol 2019 Jul 4;126:32-40. Epub 2019 Mar 4.

Department of Biochemistry and Molecular Biology, Dalian Medical University, Dalian, 116044, China. Electronic address:

Functionally uncharacterized gene Rv3627c is predicted to encode a carboxypeptidase in the pathogen of Mycobacterium tuberculosis (M. tuberculosis), which remains a major threat to human health. Here, we sought to reveal the function of Rv3627c and to elucidate its effects on mycobacterial growth. Read More

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http://dx.doi.org/10.1016/j.enzmictec.2019.03.003DOI Listing

Mortality and cardiovascular and respiratory morbidity in individuals with impaired FEV (PURE): an international, community-based cohort study.

Lancet Glob Health 2019 May;7(5):e613-e623

Population Health Research Institute, Department of Medicine, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

Background: The associations between the extent of forced expiratory volume in 1 s (FEV) impairment and mortality, incident cardiovascular disease, and respiratory hospitalisations are unclear, and how these associations might vary across populations is unknown.

Methods: In this international, community-based cohort study, we prospectively enrolled adults aged 35-70 years who had no intention of moving residences for 4 years from rural and urban communities across 17 countries. A portable spirometer was used to assess FEV. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X193007
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http://dx.doi.org/10.1016/S2214-109X(19)30070-1DOI Listing
May 2019
1 Read

Effect of the Bolsa Familia Programme on tuberculosis treatment outcomes - Authors' reply.

Lancet Glob Health 2019 May;7(5):e566

Laboratory of Epidemiology, Federal University of Espirito Santo, Vitoria, Brazil. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30153-6DOI Listing

Effect of the Bolsa Familia Programme on tuberculosis treatment outcomes.

Lancet Glob Health 2019 May;7(5):e565

Postgraduate Programme in Health Sciences, University of Southern Santa Catarina, Tubarão 88704-900, Brazil. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30152-4DOI Listing

Tuberculosis care for migrant patients in Portugal: a mixed methods study with primary healthcare providers.

BMC Health Serv Res 2019 Apr 18;19(1):233. Epub 2019 Apr 18.

Global Health and Tropical Medicine, GHTM, Instituto de Higiene e Medicina Tropical, IHMT, Universidade Nova de Lisboa, UNL, Rua da Junqueira 100, 1349-008, Lisbon, Portugal.

Background: Tuberculosis (TB) is still a major global health problem. The increasing number of cases observed among foreign-born populations contrasts with the decreasing trends observed in later years in some high-income countries. Healthcare providers are key interveners in the control of TB and HIV-TB infections. Read More

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http://dx.doi.org/10.1186/s12913-019-4050-0DOI Listing

Association between the mannose-binding lectin (MBL)-2 gene variants and serum MBL with pulmonary tuberculosis: An update meta-analysis and systematic review.

Microb Pathog 2019 Apr 15. Epub 2019 Apr 15.

Department of Respiratory Medicine and Critical Care Medicine, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, 610041, China. Electronic address:

In recent years, many studies have demonstrated that the MBL-2 gene polymorphisms may be associated with pulmonary tuberculosis (PTB) susceptibility. Moreover, some studies have shown that serum MBL levels were influenced by the MBL-2 gene polymorphisms and that it plays an important role in tuberculosis infection. However, the results of these studies were inconsistent and underpowered. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08824010193039
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http://dx.doi.org/10.1016/j.micpath.2019.04.023DOI Listing
April 2019
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Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction.

PLoS Pathog 2019 Apr 18;15(4):e1007724. Epub 2019 Apr 18.

Department of Infectious Diseases, Leiden University Medical Center, Albinusdreef 2, ZA Leiden, The Netherlands.

Type 2 diabetes mellitus (DM) is a major risk factor for developing tuberculosis (TB). TB-DM comorbidity is expected to pose a serious future health problem due to the alarming rise in global DM incidence. At present, the causal underlying mechanisms linking DM and TB remain unclear. Read More

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http://dx.doi.org/10.1371/journal.ppat.1007724DOI Listing

Sensitive electrochemiluminescence (ECL) immunoassays for detecting lipoarabinomannan (LAM) and ESAT-6 in urine and serum from tuberculosis patients.

PLoS One 2019 18;14(4):e0215443. Epub 2019 Apr 18.

Meso Scale Diagnostics, LLC., Rockville, Maryland, United States of America.

Background: Tuberculosis (TB) infection was responsible for an estimated 1.3 million deaths in 2017. Better diagnostic tools are urgently needed. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215443PLOS

Blocking IL-10 receptor signaling ameliorates Mycobacterium tuberculosis infection during influenza-induced exacerbation.

JCI Insight 2019 Apr 18;5. Epub 2019 Apr 18.

Epidemiological findings indicate that coinfection with influenza viruses is associated with an increased risk of death in patients suffering from tuberculosis but the underlying pathomechanisms are not well understood. In this study, we demonstrate that influenza A virus (IAV) coinfection rapidly impairs control of Mycobacterium tuberculosis (Mtb) in C57BL/6 mice. IAV coinfection was associated with significantly increased bacterial loads, reduced survival and a substantial modulation of innate and adaptive immune defenses including an impaired onset and development of Mtb-specific CD4+ T cell responses and the accumulation of macrophages with increased arginase-1 production in the lungs. Read More

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http://insight.jci.org/articles/view/126533
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http://dx.doi.org/10.1172/jci.insight.126533DOI Listing
April 2019
1 Read

The role of mediastinoscopy in the diagnosis of thoracic disease: 107-case analysis.

Med Glas (Zenica) 2019 Aug 1;16(2). Epub 2019 Aug 1.

Department of Thoracic Surgery, School of Medicine, Canakkale Onsekiz Mart University, Turkey.

Aim To evaluate the efficacy, safety and feasibility of mediastinoscopy in 107 cases with mediastinal lesions that could not be diagnosed histopathologically with other methods. Methods A total of 107 cases (73 males, 34 females; mean age 57.4, range 30-88 years) with mediastinal lymphadenopathy, who underwent mediastinoscopy between 12 September 2012 and 29 November 2018 were examined retrospectively. Read More

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http://ljkzedo.ba/mgpdf/mg31/01_Kapicibasi_1001_A.pdf
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http://dx.doi.org/10.17392/1001-19DOI Listing
August 2019
1 Read

Optimal Sampling Strategies for Therapeutic Drug Monitoring of First-Line Tuberculosis Drugs in Patients with Tuberculosis.

Clin Pharmacokinet 2019 Apr 17. Epub 2019 Apr 17.

Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, PO Box 30.001, 9700 RB, Groningen, The Netherlands.

Background: The 24-h area under the concentration-time curve (AUC)/minimal inhibitory concentration ratio is the best predictive pharmacokinetic/pharmacodynamic (PK/PD) parameter of the efficacy of first-line anti-tuberculosis (TB) drugs. An optimal sampling strategy (OSS) is useful for accurately estimating AUC; however, OSS has not been developed in the fed state or in the early phase of treatment for first-line anti-TB drugs.

Methods: An OSS for the prediction of AUC of isoniazid, rifampicin, ethambutol and pyrazinamide was developed for TB patients starting treatment. Read More

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http://dx.doi.org/10.1007/s40262-019-00763-3DOI Listing

Challenges in urogenital tuberculosis.

World J Urol 2019 Apr 17. Epub 2019 Apr 17.

Novosibirsk Research TB Institute, Urogenital Clinic, Novosibirsk, Russian Federation.

Purpose: For better understanding of urogenital tuberculosis (UGTB), its clinical spectrum and characteristic features need to be evaluated.

Materials And Methods: One hundred and forty-two cases of UGTB patients were analyzed retrospectively. We considered age, gender, symptoms, and diagnostic procedures. Read More

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http://dx.doi.org/10.1007/s00345-019-02767-xDOI Listing

Tuberculosis in Singapore: Past and Future.

Ann Acad Med Singapore 2019 Mar;48(3):72-74

Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

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March 2019
1 Read

Improving TB infection control in a regional hospital in the Eastern Cape, South Africa.

BMJ Open Qual 2019 1;8(1). Epub 2019 Mar 1.

Improving Global Health through Leadership Development, NHS Thames Valley and Wessex Leadership Academy, Otterbourne, UK.

This quality improvement (QI) work was carried out in Cecilia Makiwane Hospital (CMH), a regional public hospital in the Eastern Cape, South Africa (SA). SA has among the highest incidence of tuberculosis (TB) in the world and this is a leading cause of death in SA. Nosocomial infection is an important source of TB transmission. Read More

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http://qir.bmj.com/lookup/doi/10.1136/bmjoq-2018-000347
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http://dx.doi.org/10.1136/bmjoq-2018-000347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440607PMC
March 2019
1 Read

Biophysical and ultrasonographic changes in lichen planus compared with uninvolved skin.

Int J Womens Dermatol 2019 Jun 16;5(2):100-104. Epub 2018 Nov 16.

Center for Research and Training in Skin Diseases and Leprosy, Tehran University of Medical Sciences, Tehran, Iran.

Background: Lichen planus (LP) is a chronic inflammatory disease of the skin. Currently, noninvasive techniques are used to evaluate biophysical properties of the skin in vivo.

Objective: In this study, we aimed to evaluate skin biophysical properties in patients with LP and make a comparison between involved and uninvolved skin to provide a better understanding of the pathogenesis of LP. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475183004
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http://dx.doi.org/10.1016/j.ijwd.2018.10.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451735PMC
June 2019
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Short Course of High-dose Steroids for Anaphylaxis Caused Flare Up of Tuberculosis: A Case Report.

J Transl Int Med 2019 Mar 29;7(1):39-42. Epub 2019 Mar 29.

MIMSR Medical College Latur India, Latur, Maharashtra, India.

A 25-year-old male patient received high-dose intravenous steroids for life-threatening anaphylaxis because of bee sting only for 4 days resulted in reactivation of latent tuberculosis infection (LTBI). Clinical presentation is acute form of progressive pulmonary tuberculosis with pleural efusion that can be misdiagnosed as a community-acquired pneumonia. High index of suspicion with adequate evaluation is must in all cases to have satisfactory treatment outcome. Read More

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http://content.sciendo.com/view/journals/jtim/7/1/article-p3
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http://dx.doi.org/10.2478/jtim-2019-0008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463822PMC
March 2019
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Biochemical characterization of acyl-coenzyme A synthetases involved in mycobacterial steroid side-chain catabolism and molecular design: synthesis of an anti-mycobacterial agent.

3 Biotech 2019 May 8;9(5):169. Epub 2019 Apr 8.

College of Life Sciences, Sichuan Normal University, Chengdu, 610068 People's Republic of China.

The metabolism of host cholesterol by is an important factor for both its virulence and pathogenesis. However, the rationale for this cholesterol metabolism has not been fully understood yet. In the present study, we characterized several previously undescribed acyl-CoA synthetases that are involved in the steroid side-chain degradation in , and an analogue of intermediate from steroid degradation, 5'--(lithocholoyl sulfamoyl) adenosine (LCA-AMS), was successfully designed and synthesized to be used as a specific anti-mycobacterial agent. Read More

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http://link.springer.com/10.1007/s13205-019-1703-y
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http://dx.doi.org/10.1007/s13205-019-1703-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453995PMC
May 2019
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Assessment of the specificity of a gamma-interferon test performed with specific antigens to detect bovine tuberculosis, after non-negative results to intradermal tuberculin testing.

Vet Rec Open 2019 17;6(1):e000335. Epub 2019 Mar 17.

Epidemiology of Animal Infectious Diseases Unit, Ecole Nationale Veterinaire d\'Alfort, Maisons-Alfort, France.

In cattle herds in France, cervical skin tests (STs) using simple intradermal tuberculin (SIT) are performed to detect bovine tuberculosis (bTB). When positive results are found on ST screening, the herd is considered to be 'under suspicion' and confined, raising economic issues. The suspicion can be lifted by carrying out a single intradermal cervical comparative test (SICCT) at least six weeks later. Read More

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http://vetrecordopen.bmj.com/lookup/doi/10.1136/vetreco-2019
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http://dx.doi.org/10.1136/vetreco-2019-000335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446210PMC
March 2019
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Tuberculosis drug resistance in Canada: 2017.

Can Commun Dis Rep 2018 Nov 1;44(11):290-296. Epub 2018 Nov 1.

Centre for Communicable Disease and Infection Control, Public Health Agency of Canada, Ottawa, ON.

Background: Drug-resistant tuberculosis (TB) is a global public health issue. To monitor this in Canada, surveillance systems have been in place for the last 20 years.

Objective: To describe drug resistance patterns among TB isolates in Canada in 2017 by type of resistance as well as geographic location, demographic data and origin and to compare current data to those of the previous 10 years. Read More

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http://dx.doi.org/10.14745/ccdr.v44i11a04DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449088PMC
November 2018

Blood Lead Levels Among Resettled Refugee Children in Select US States, 2010-2014.

Pediatrics 2019 Apr 17. Epub 2019 Apr 17.

Immigrant, Refugee, and Migrant Health Branch, Division of Global Migration and Quarantine, Centers for Disease Control and Prevention, Atlanta, Georgia.

Background: Elevated blood lead levels (EBLLs; ≥5 µg/dL) are more prevalent among refugee children resettled in the United States than the general US population and contribute to permanent health and neurodevelopmental problems. The Centers for Disease Control and Prevention recommends screening of refugee children aged 6 months to 16 years on arrival in the United States and retesting those aged 6 months to 6 years between 3- and 6-months postarrival.

Methods: We analyzed EBLL prevalence among refugee children aged 6 months to 16 years who received a domestic refugee medical examination between January 1, 2010 and September 30, 2014. Read More

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http://dx.doi.org/10.1542/peds.2018-2591DOI Listing
April 2019
5.473 Impact Factor

A genome-wide haploid genetic screen identifies heparan sulfate-associated genes and the macropinocytosis modulator TMED10 as factors supporting vaccinia virus infection.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands

Vaccinia virus is a promising viral vaccine and gene delivery candidate, and has historically been used as a model to study poxvirus-host cell interactions. We employed a genome-wide insertional mutagenesis approach in human haploid cells to identify host factors crucial for vaccinia virus infection. A library of mutagenized HAP1 cells was exposed to Modified Vaccinia Virus Ankara (MVA). Read More

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http://dx.doi.org/10.1128/JVI.02160-18DOI Listing