260,319 results match your criteria Tuberculosis


Change of Pyogenic and Tuberculous Spondylitis between 2007 and 2016 Year : A Nationwide Study.

J Korean Neurosurg Soc 2020 Jul 6. Epub 2020 Jul 6.

Department of Neurosurgery, Bundang CHA Medical Center, CHA University College of Medicine, Seongnam, Korea.

Objective: We attempted to compare the incidence of pyogenic spondylitis (PS) and tuberculous spondylitis (TS) between 2007 and 2016. Furthermore, we investigated the patients who underwent surgery in 2016 compared to that in 2007.

Methods: We used a nationwide database managed by the Korean National Health Insurance Service (NHIS) in 2007 and 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3340/jkns.2020.0013DOI Listing

Development of a reliable bioanalytical method based on prostate specific antigen trapping on the cavity of molecular imprinted polymer towards sensing of PSA using binding affinity of PSA-MIP receptor: A novel biosensor.

J Pharm Biomed Anal 2020 Jun 26;188:113447. Epub 2020 Jun 26.

Department of Science and Technology, Physics, Electronics and Mathematics Linköping University, Sweden.

In this study, electrically-conducting poly [Toluidine Blue (PTB)] was applied as artificial receptor. It was organized by molecular imprinting approaches and via electrochemical technique for the sensitive monitoring of prostate-specific antigen (PSA). The protein-imprinted PTB was electropolymerized in a pre-formed glutaraldehyde-cysteamine (GA-Cys A) matrix on the surface of gold electrode, which significantly boosted the stability against degradation of the Molecular Imprinted Polymer (MIP) on the surface of pre-modified gold electrode. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpba.2020.113447DOI Listing

Review of automated DNA extraction systems for sequencing-based solutions for drug-resistant tuberculosis detection.

Diagn Microbiol Infect Dis 2020 May 30;98(2):115096. Epub 2020 May 30.

Foundation for Innovative New Diagnostics, Geneva, Switzerland; Department of Medicine, University of California, San Diego, California, USA.

Robust clinical specimen nucleic acid extraction instrumentation and methods are critical to the performance of downstream molecular diagnostics for the diagnosis of drug-resistant tuberculosis (DR-TB). Currently, there is a high level of interest in sequencing-based solutions for rapid and comprehensive DR-TB testing from primary specimens (i.e. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.diagmicrobio.2020.115096DOI Listing

Synthesis and structure activity relationships of cyanopyridone based anti-tuberculosis agents.

Eur J Med Chem 2020 Jun 12;201:112450. Epub 2020 Jun 12.

Laboratory for Medicinal Chemistry (FFW), Ghent University, Ottergemsesteenweg 460, B9000, Gent, Belgium. Electronic address:

Mycobacterium tuberculosis, the causative agent of tuberculosis, relies on thymidylate kinase (MtbTMPK) for the synthesis of thymidine triphosphates and thus also DNA synthesis. Therefore, this enzyme constitutes a potential Achilles heel of the pathogen. Based on a previously reported MtbTMPK 6-aryl-substituted pyridone inhibitor and guided by two co-crystal structures of MtbTMPK with pyridone- and thymine-based inhibitors, we report the synthesis of a series of aryl-shifted cyanopyridone analogues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejmech.2020.112450DOI Listing

Characteristics of Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome and its Influence on Tuberculosis Treatment Outcomes in Persons Living with HIV.

Int J Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil; Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Salvador, Brazil; Curso de Medicina, Faculdade de Tecnologia e Ciências (UniFTC), Salvador, Brazil; Universidade Salvador (UNIFACS), Laureate Universities, Salvador, Brazil; Escola Bahiana de Medicina e Saúde Pública (EBMSP), Salvador, Brazil; Wellcome Centre for Infectious Disease Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, 7925, South Africa. Electronic address:

Objective: Tuberculosis (TB)-associated immune reconstitution inflammatory Syndrome (IRIS) influence on TB treatment outcomes and its risk factors were investigated among persons with HIV coinfected with TB.

Methods: Newly diagnosed, culture-confirmed, pulmonary TB patients with HIV, enrolled in a clinical trial (NCT00933790) were retrospectively analyzed for IRIS occurrence. Risk factors and TB outcomes (for up to 18 months after initiation of anti-TB treatment [ATT]) were compared between patients experiencing IRIS (IRIS group) and those who did not (Non-IRIS group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2020.06.097DOI Listing

Methods in isolation and characterization of bovine monocytes and macrophages.

Methods 2020 Jul 2. Epub 2020 Jul 2.

Department of Veterinary Medicine, Università degli Studi di Milano, Milan, Italy.

Monocytes and macrophages belong to the mononuclear phagocyte system and play important roles in both physiological and pathological processes. The cells belonging to the monocyte/macrophage system are structurally and functionally heterogeneous. Several subsets of monocytes have been previously identified in mammalian blood, generating different subpopulations of macrophages in tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ymeth.2020.06.017DOI Listing

24-locus MIRU-VNTR and Spoligotyping analysis of drug-resistant Mycobacterium tuberculosis strains isolated from Northeastern Thailand.

Infect Genet Evol 2020 Jul 1:104449. Epub 2020 Jul 1.

Centre for Research and Development of Medical Diagnostic Laboratories (CMDL), Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand; Department of Clinical Microbiology, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Tuberculosis, caused by Mycobacterium tuberculosis (MTB) infection, remains a global health problem with increased concerns due to drug-resistant tuberculosis. However, molecular genotyping profiles may give insight of the transmission of TB in a particular region. The present study aimed to characterize the genetic diversity of drug-resistant MTB and evaluate primer sets applied for the epidemiological study of circulating MTB in Northeastern Thailand. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.meegid.2020.104449DOI Listing

Efficacy of vitamin D supplementation for the prevention of pulmonary tuberculosis and mortality in HIV: a randomised, double-blind, placebo-controlled trial.

Lancet HIV 2020 Jul;7(7):e463-e471

Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.

Background: Observational data suggest that low vitamin D status is associated with an increased incidence of pulmonary tuberculosis and mortality among people living with HIV. The primary aims of this study were to assess the effect of vitamin D supplementation on the risk of mortality and incidence of pulmonary tuberculosis among adults initiating antiretroviral therapy (ART).

Methods: This was a randomised, double-blind, placebo-controlled trial of vitamin D supplementation among adults living with HIV who initiated ART and had serum 25-hydroxyvitamin D concentrations of less than 30 ng/mL at four large HIV care and treatment centres in Dar es Salaam, Tanzania. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3018(20)30108-9DOI Listing

The problem with vitamin D supplementation for tuberculosis.

Lancet HIV 2020 Jul;7(7):e450-e451

Harvard Medical School, Department of Global Health and Social Medicine, Boston, MA 02115, USA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/S2352-3018(20)30114-4DOI Listing

In-Lipid Structure of Pressure-Sensitive Domains Hints Mechanosensitive Channel Functional Diversity.

Biophys J 2020 Jun 23. Epub 2020 Jun 23.

Biomedical Sciences Research Complex, School of Biology, University of St Andrews, St Andrews, United Kingdom; Astbury Centre for Structural and Molecular Biology, University of Leeds, Leeds, United Kingdom; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom. Electronic address:

The mechanosensitive channel of large conductance (MscL) from Mycobacterium tuberculosis has been used as a structural model for rationalizing functional observations in multiple MscL orthologs. Although these orthologs adopt similar structural architectures, they reportedly present significant functional differences. Subtle structural discrepancies on mechanosensitive channel nanopockets are known to affect mechanical gating and may be linked to large variability in tension sensitivity among these membrane channels. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bpj.2020.06.012DOI Listing

Fine Needle Aspiration Biopsy of Peripheral Lymph Nodes in Children: Practical Experience in a Tertiary Hospital.

J Trop Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Background: Peripheral lymphadenopathy occurs often in children; fine needle aspiration biopsy (FNAB) is a commonly performed diagnostic procedure. We describe FNAB use and outcome for peripheral lymphadenopathy in children in a routine clinical setting.

Methods: A retrospective study done at Tygerberg Hospital, Cape Town of children (<13 years) who had an FNAB for lymphadenopathy from July 2012 to June 2014. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/tropej/fmaa040DOI Listing

Significance of granuloma and granulomatous lymphangitis in the differential diagnosis of Crohn's disease.

J Dig Dis 2020 Jul 3. Epub 2020 Jul 3.

Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Aim: To clarify the pathological characteristics of granuloma and granulomatous lymphangitis in patients with non-neoplastic bowel diseases and to compare their significance in the differential diagnosis of Crohn's disease.

Methods: Samples were collected from 78 cases of Crohn's disease, 11 cases of intestinal tuberculosis and 33 patients suffering from other non-neoplastic bowel diseases. All patients underwent partial enterectomy and histopathological examination. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/1751-2980.12919DOI Listing

Mullen Scales of Early Learning Adaptation for Assessment of Indian Children and Application to Tuberculous Meningitis.

J Trop Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Department of Rehabilitation Psychology and Neuropsychology, The Institute for Rehabilitation and Research (TIRR) Memorial Hermann, Houston, TX, USA.

Introduction: Tuberculous meningitis (TBM) results in significant morbidity and mortality among children worldwide. Associated neurocognitive complications are common but not well characterized. The Mullen Scales of Early Learning (MSEL), a well-established measure for assessment of neurodevelopment, has not yet been adapted for use in India. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/tropej/fmaa034DOI Listing

Latent Tuberculosis Infection Increases in Kidney Transplantation Recipients Compared With Transplantation Candidates: A Neglected Perspective in Tuberculosis Control.

Clin Infect Dis 2020 Jul 4. Epub 2020 Jul 4.

College of Medicine, National Taiwan University, Taipei, Taiwan.

Background: The prevalence and incidence of latent tuberculosis infection (LTBI) in patients with kidney transplantation remain unclear.

Methods: In this prospective study, we enrolled kidney transplantation candidates (KTCs) and recipients (KTRs) from 2014 to 2018. We defined LTBI as a positive result of QuantiFERON-TB Gold In-tube (QFT). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/cid/ciz851DOI Listing

Genome-wide identification of DNA-PKcs-associated RNAs by RIP-Seq.

Signal Transduct Target Ther 2019 Jul 5;4(1):22. Epub 2019 Jul 5.

Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, 100850, Beijing, People's Republic of China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41392-019-0057-6DOI Listing

The curative effects of shortwave diathermy on treating Novel coronavirus (COVID-19) pneumonia: A structured summary of a study protocol for a randomised controlled trial.

Trials 2020 Jul 3;21(1):609. Epub 2020 Jul 3.

Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Objectives: To evaluate the therapeutic effects of ultra-short-wave diathermy (SWD) on COVID-19 pneumonia. The hypothesis is that SWD may minimise pneumonic inflammation and shorten the duration of the time to positive-to-negative conversion of COVID-19 nucleic acid test.

Trial Design: This is a single centre, 2-arm (1:1 ratio), evaluator blinded, parallel group design superiority randomised, controlled clinical trial. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13063-020-04534-5DOI Listing

Dynamic changes of D-dimer and neutrophil-lymphocyte count ratio as prognostic biomarkers in COVID-19.

Respir Res 2020 Jul 3;21(1):169. Epub 2020 Jul 3.

Department of Geriatrics, Xinhua Hospital, School of Medicine, Institute of Hospital Development Strategy, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, 200092, China.

Background: Since December 2019, the outbreak of COVID-19 caused a large number of hospital admissions in China. Many patients with COVID-19 have symptoms of acute respiratory distress syndrome, even are in danger of death. This is the first study to evaluate dynamic changes of D-Dimer and Neutrophil-Lymphocyte Count Ratio (NLR) as a prognostic utility in patients with COVID-19 for clinical use. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12931-020-01428-7DOI Listing

Interplay between alveolar epithelial and dendritic cells and Mycobacterium tuberculosis.

J Leukoc Biol 2020 Jul 3. Epub 2020 Jul 3.

Basic and Applied Immunology Program, Department of Biochemistry and Immunology, Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil.

The innate response plays a crucial role in the protection against tuberculosis development. Moreover, the initial steps that drive the host-pathogen interaction following Mycobacterium tuberculosis infection are critical for the development of adaptive immune response. As alveolar Mϕs, airway epithelial cells, and dendritic cells can sense the presence of M. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/JLB.4MR0520-112RDOI Listing

How antibiotics work together: molecular mechanisms behind combination therapy.

Curr Opin Microbiol 2020 Jun 30;57:31-40. Epub 2020 Jun 30.

ARC Centre of Excellence in Synthetic Biology, Department of Molecular Sciences, Macquarie University, North Ryde, 2113, Australia. Electronic address:

Antibiotics used in combination are an effective strategy for combatting numerous infectious diseases in clinical and veterinary settings, particularly as a last-line therapy for difficult-to-treat cases. Combination therapy can either increase or slow the rate of killing, broaden the antibiotic spectrum, reduce dosage and unwanted side-effects, and even control the emergence of resistance. The administration of antibiotics in combination has been used effectively against bacterial infections for >70 years, first used to treat tuberculosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mib.2020.05.012DOI Listing

Investigation of genetic susceptibility to Mycobacterium tuberculosis (VDR and IL10 genes) in a population with a high level of substructure in the Brazilian Amazon region.

Int J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Faculty of Medicine, Federal University of Pará: 01 Augusto Corrêa Street, University City Prof. José Silveira Netto, 66075-970, Belém, PA, Brazil; Laboratory of Human and Medical Genetics, Federal University of Pará: 1 Augusto Corrêa Street, University City Prof. José Silveira Netto, 66075-970, Belém, PA, Brazil; Nucleus of Oncology Research, High Complexity in Oncology Unit, University Hospital João de Barros Barreto: 4487 Dos Mundurucus Street, 66073-000. Belém, PA, Brazil. Electronic address:

Objectives: Tuberculosis (TB) is an infectious and contagious disease that is very influential in human history and presents high rates of mortality. The objective of this study was to investigate the association ofVDR, IL10 and SLC11A1 gene polymorphisms with susceptibility to presence of tuberculosis infection.

Methods: A total of 135 patients with confirmed tuberculosis and 141 healthy individuals were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ijid.2020.06.090DOI Listing

Specific gyrA gene mutations correlate with high prevalence of discordant levofloxacin resistance in Mycobacterium tuberculosis isolates from Beijing, China.

J Mol Diagn 2020 Jun 30. Epub 2020 Jun 30.

National Clinical Laboratory on Tuberculosis, Beijing Key laboratory on Drug-resistant Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China. Electronic address:

Although rapid, highly sensitive molecular diagnostics tests are useful for diagnosing fluoroquinolone (FQ)-resistant tuberculosis (TB), results of molecular testing versus conventional sequential phenotypic drug susceptibility testing (pDST) are frequently discordant. Here we determined the discordance rate of levofloxacin (LFX) resistance results obtained via MeltPro TB molecular testing versus pDST of clinical TB isolates collected in Beijing, China between January and December 2018. Isolates with discordant results were further subjected to LFX minimal inhibitory concentration (MIC) determinations and DNA sequence analysis to explore causes of discordance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jmoldx.2020.06.010DOI Listing

Patients with tuberculous meningitis and hepatitis B co-infection have increased risk for antituberculosis drug-induced liver injury and poor outcomes.

Infect Dis (Lond) 2020 Jul 3:1-7. Epub 2020 Jul 3.

Department of Infectious Diseases, Nanfang Hospital of Southern Medical University, Guangzhou, China.

Tuberculous meningitis (TBM) is one of the most severe forms of tuberculosis. Previous studies reported that hepatitis B virus (HBV) infection could increase the risk of antituberculosis drug-induced liver injury (ATB-DILI) in pulmonary tuberculosis patients. To date, only a few studies exist on the effect of HBV on TBM. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23744235.2020.1788223DOI Listing

Head-to-head comparison of the diagnostic accuracy of Xpert MTB/RIF and Xpert MTB/RIF Ultra for tuberculosis: a meta-analysis.

Infect Dis (Lond) 2020 Jul 3:1-13. Epub 2020 Jul 3.

Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.

: Tuberculosis (TB) diagnosis has significantly improved since the introduction of the automated molecular test Xpert MTB/RIF (Xpert) and the new version Xpert MTB/RIF Ultra (Ultra) that detect . Due to the rapidly widespread use of Xpert and Ultra, we conducted a meta-analysis to compare the performances of Xpert and Ultra in diagnosing TB and discuss the advantages and limitations of these two tests.: Web of Science, Medline ( PubMed), Embase ( OvidSP), the Cochrane Central Register of Controlled Trials and Google Scholar (up to April 2020) were searched for relevant studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/23744235.2020.1788222DOI Listing

Risk stratification and management of QuantiFERON-positive solid-organ living donors.

Curr Opin Organ Transplant 2020 Jun 30. Epub 2020 Jun 30.

Division of Infectious Diseases, Department of Medicine, Keck School of Medicine at the University of Southern California (USC), Los Angeles, California, USA.

Purpose Of Review: Donor-derived disease with Mycobacterium tuberculosis (MTB) is likely to become more common as donor pools expand due to increasing transplant volume coupled with patterns of migration and global mobility. Our article reviews the current literature and provides a rational approach for clinicians managing the scenario of a living donor who has epidemiologic risk factors for tuberculosis exposure.

Recent Findings: Tuberculous bacilli, formerly thought to exist latently only in pulmonary granulomas, are now known reside dormant in nonpulmonary organs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOT.0000000000000787DOI Listing

Case Report: Dynamics of Acquired Fluoroquinolone Resistance under Standardized Short-Course Treatment of Multidrug-Resistant Tuberculosis.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium.

We report a case of acquired fluoroquinolone (FQ) resistance under short-course multidrug-resistant tuberculosis (MDR-TB) treatment. The patient was managed at Kabutare hospital, one of the two specialized MDR-TB clinics in Rwanda. A low dose of moxifloxacin was used in the first three critical months. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.20-0201DOI Listing

Out-of-Pocket Costs for Patients Diagnosed with Tuberculosis in Different Healthcare Settings in Bandung, Indonesia.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Internal Medicine, Faculty of Medicine, Hasan Sadikin General Hospital, Universitas Padjadjaran, Bandung, Indonesia.

Costs related to tuberculosis (TB) can impose a significant burden on patients and their families and create barriers to diagnosis and treatment. Our study aimed to quantify out-of-pocket costs expended by TB patients in Bandung, Indonesia. This cross-sectional study recruited adults with TB from community health centers (CHCs), public and private hospitals, and private practitioners (PPs). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.19-0848DOI Listing

Predictors of Loss to Follow-Up among Men with Tuberculosis in Puducherry and Tamil Nadu, India.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Medicine, Section of Infectious Diseases, Boston University School of Medicine, Boston, Massachusetts.

Identifying predictors of loss to follow-up (LTFU; treatment lapse ≥ 2 months) among people with tuberculosis (TB) may assist programmatic efforts in controlling the spread of TB. Newly diagnosed smear-positive TB patients were enrolled in the Regional Prospective Observational Research for TB study in Puducherry and Tamil Nadu, India. Treatment records were used to identify LTFU of those who were enrolled from May 2014 through December 2017. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4269/ajtmh.19-0415DOI Listing

A Case of Testicular Granulomatous Inflammation Mistaken for Malignancy: Tuberculosis Identified Post Orchiectomy.

J Investig Med High Impact Case Rep 2020 Jan-Dec;8:2324709620938947

UCLA Kern Medical, Los Angeles, CA, USA.

We describe the case of a 41-year-old Hispanic male, inconsistently adherent to visits and workup due to socioeconomic challenges, who presented with a right testicular mass. Because of the overriding concern that this was malignant, he underwent a right orchiectomy. Pathology revealed granulomatous disease with no evidence of malignancy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/2324709620938947DOI Listing

History of Acquired Immune Deficiency Syndrome in Korea.

Infect Chemother 2020 Jun;52(2):234-244

Division of Infectious Diseases, Department of Internal Medicine, National Medical Center, Seoul, Korea.

The first human immunodeficiency virus (HIV) infection was reported in Korea in 1985. The number of HIV-infected persons domestically increased in the 1990s showing epidemic indigenousization. Since then, the number of new infections gradually increased every year, and recently more than 1,000 newly infected cases were reported per year. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3947/ic.2020.52.2.234DOI Listing

Nanoparticle-mediated macrophage targeting-a new inhalation therapy tackling tuberculosis.

Drug Deliv Transl Res 2020 Jul 2. Epub 2020 Jul 2.

Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt.

Despite the potent clinical efficacy of linezolid (LNZ) against drug-resistant tuberculosis, its safety and tolerability remain of major concern. Our objective is to develop antitubercular inhalable LNZ nano-embedded microparticles. In this context, LNZ incorporated in non-structured lipid carriers (NLCs) was characterized in terms of colloidal, morphological, thermal, and release profiles. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13346-020-00815-3DOI Listing

Nodular distribution pattern on chest computed tomography (CT) in patients diagnosed with nontuberculous mycobacteria (NTM) infections.

Wien Klin Wochenschr 2020 Jul 2. Epub 2020 Jul 2.

Emergency Department of Zagreb County, Matice Hrvatske, Zagreb, Croatia.

Background: This study evaluated the prevalence of spreading pathways in nontuberculous mycobacteria (NTM) pulmonary infections according to nodular distribution patterns seen on chest computed tomography (CT).

Methods: This study included 63 patients diagnosed with NTM lung infections who underwent CT at our institution. A retrospective analysis of CT images focused on the presence and distribution of nodules, presence of intrathoracic lymphadenopathy and the predominant side of infection in the lungs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00508-020-01701-1DOI Listing

Retrospective analysis of 1,641 cases of classic fever of unknown origin.

Ann Transl Med 2020 Jun;8(11):690

Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.

Background: Fever of unknown origin (FUO) is commonly defined as fever higher than 38.3 °C on several occasions during at least 3 weeks with uncertain diagnosis after a number of obligatory investigations. It is a special type of fever and a common disease in internal medicine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm-20-3875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7327343PMC

African histoplasmosis of the penis.

Oxf Med Case Reports 2020 Jun 25;2020(6):omaa043. Epub 2020 Jun 25.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

African Histoplasmosis is deep mycosis caused by and genitourinary involvement is extremely rare. We report a case of African histoplasmosis in a 27-year-old subject with painful penis ulcer. Ulcer edge biopsy had revealed inflammatory granulomas made of epithelioid cells, lymphoplasmocytes, polynuclear eosinophils and giant multinucleated cells, with ovoid yeasts surrounded by a clear halo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/omcr/omaa043DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7315929PMC

Antimicrobial Susceptibility of Complex Clinical Isolates from a Chinese Tertiary Hospital.

Infect Drug Resist 2020 26;13:2001-2010. Epub 2020 Jun 26.

Department of Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200082, People's Republic of China.

Introduction: complex (MABC) is a group of important infectious agents that are highly associated with drug resistance, and antibiotic treatment is usually ineffective. This study investigated the characteristics of antimicrobial susceptibility of MABC isolates and the synergy between certain β-lactam combinations against MABC infection.

Methods: We collected 129 MABC isolates from patients with lower respiratory tract infections and categorized them into three subspecies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2147/IDR.S252485DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7326206PMC

Factors influencing diagnosis and treatment initiation for multidrug-resistant/rifampicin-resistant tuberculosis in six sub-Saharan African countries: a mixed-methods systematic review.

BMJ Glob Health 2020 Jul;5(7)

École de santé publique de l'Université de Montréal (ESPUM), Montréal, Quebec, Canada.

Background: Drug-resistant tuberculosis burdens fragile health systems in sub-Saharan Africa (SSA), complicated by high prevalence of HIV. Several African countries reported large gaps between estimated incidence and diagnosed or treated cases. Our review aimed to identify barriers and facilitators influencing diagnosis and treatment for drug-resistant tuberculosis (DR-TB) in SSA, which is necessary to develop effective strategies to find the missing incident cases and improve quality of care. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1136/bmjgh-2019-002280DOI Listing

Evaluating the effectiveness of anti-tuberculosis treatment by detecting Mycobacterium tuberculosis 85B messenger RNA expression in sputum.

J Infect Public Health 2020 Jun 29. Epub 2020 Jun 29.

Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine, Department of Medical Microbiology, Istanbul, Turkey.

Background: The antigen 85 complex (85B) is secreted in large quantities from growing mycobacteria and the presence of bacterial mRNA is an indicator of cell viability. The quantitative detection of 85B mRNA expression levels can be used to assess the success of anti-tuberculosis treatment outcomes to detect viable mycobacteria cells. Therefore, we evaluated the levels of 85B mRNA of Mycobacterium tuberculosis strains in patients with pulmonary tuberculosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jiph.2020.05.016DOI Listing

[Pulmonary mycosis in patients with diabetes mellitus. Clinical characteristics and risk factors].

Rev Iberoam Micol 2020 Jun 29. Epub 2020 Jun 29.

Dirección de Investigación, Hospital General de México "Dr. Eduardo Liceaga", Ciudad de México, México.

Background: Diabetes mellitus is a public health problem in Mexico, and the trend of the disease is increasing. From 2000 to 2017, 7.32 million new cases were diagnosed, with pulmonary mycoses being one of the most serious complications. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.riam.2020.04.002DOI Listing

6,6'-Aryl trehalose analogs as potential Mincle ligands.

Bioorg Med Chem 2020 Jul 31;28(14):115564. Epub 2020 May 31.

Department of Chemistry and Biochemistry, University of Montana, 32 Campus Drive, Missoula, MT 59812, United States; Center for Translational Medicine, University of Montana, 32 Campus Drive, Missoula, MT 59812, United States. Electronic address:

6,6'-Aryl trehalose derivatives have been synthesized with a view towards identifying novel Th-17-inducing vaccine adjuvants based on the high affinity Mincle ligand Brartemicin. The initial structure-activity relationships of these novel trehalose-based compounds were investigated. All compounds have been evaluated for their ability to engage the Mincle receptor and induce a potential pro-Th17 cytokine profile from human peripheral blood mononuclear cells based on IL-6 production in human peripheral blood mononuclear cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmc.2020.115564DOI Listing

Tuberculin skin test conversion in patients under treatment with anti-tumor necrotizing factor alpha agents.

BMC Infect Dis 2020 Jul 2;20(1):464. Epub 2020 Jul 2.

Internal medicine department, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Despite successful clinical outcomes of biologic medications in patients with chronic rheumatic diseases, some considerable adverse effects such as infections remain a major concern. Possibility of tuberculosis (TB) reactivation over treatment with anti-tumor necrotizing factor (TNF) alpha agents has necessitated a screening test before initiation of treatment. However, screening over the course of treatment is not recommended in those patients with negative baseline screening tests. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05166-5DOI Listing

Use of resuscitation promoting factors to screen for tuberculosis infection in household-exposed children in The Gambia.

BMC Infect Dis 2020 Jul 2;20(1):469. Epub 2020 Jul 2.

Vaccines and Immunity Theme, MRC Unit The Gambia at London School of Hygiene & Tropical Medicine, Fajara, The Gambia.

Background: Interferon-γ release assays (IGRA) with Resuscitation promoting factor (Rpf) proteins enhanced tuberculosis (TB) screening and diagnosis in adults but have not been evaluated in children. Children often develop paucibacillary TB and their immune response differs from that of adults, which together affect TB disease diagnostics and immunodiagnostics. We assessed the ability of Rpf to identify infection among household TB-exposed children in The Gambia and investigated their ability to discriminate Mycobacterium tuberculosis complex (MTBC) infection from active TB disease in children. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12879-020-05194-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7330976PMC

"Knock Knock": a qualitative study exploring the experience of household contacts on home visits and their attitude towards people living with TB in South Africa.

BMC Public Health 2020 Jul 2;20(1):1047. Epub 2020 Jul 2.

The Aurum Institute, 29 Queens Road, Parktown, Johannesburg, Gauteng, 2193, South Africa.

Background: Household contract tracing (HHCT) is an important strategy for active tuberculosis case finding and offers an opportunity for testing of other diseases such as HIV. However, there is limited data on the patient-centered approach to HHCT. Our study aimed to describe experiences and preferences of household contacts (HHCs) for HHCT. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s12889-020-09150-1DOI Listing

Monogenic Primary Immunodeficiency Disorder Associated with Common Variable Immunodeficiency and Autoimmunity.

Int Arch Allergy Immunol 2020 Jul 2:1-9. Epub 2020 Jul 2.

Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Science, Tehran, Iran,

Background: Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency disorder mainly characterized by recurrent bacterial infections besides other immunological defects including loss of or dysfunction of B cells and decreased immunoglobulin levels. In this study, our aim is to evaluate clinical, immunological, and molecular data of patients with a primary clinical diagnosis of CVID and autoimmune phenotype with a confirmed genetic diagnosis.

Methods: Among 297 patients with CVID, who were registered in the Iranian Primary Immunodeficiency Registry at Children's Medical Center Hospital in Iran, 83 patients have been genetically examined and 27 patients with autoimmunity and confirmed genetic mutations were selected for analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000508817DOI Listing

Unusual Periventricular Hemorrhage as the initial manifestation of Central Nervous System Tuberculosis: A case report.

World Neurosurg 2020 Jun 29. Epub 2020 Jun 29.

Neurology Department, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Background: Intracranial hemorrhage (ICH) is a rare complication of central nervous system (CNS) tuberculosis, and intra-tuberculoma hemorrhage is even rarer. Periventricular hemorrhage caused by CNS tuberculosis has not been reported so far. In this paper, we exhibited the peculiar neuroradiological manifestations of periventricular hemorrhage secondary to CNS tuberculosis and discussed possible mechanisms of intra-tuberculoma hemorrhage supported by neuroradiological findings. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.wneu.2020.06.193DOI Listing

mycoCSM: using graph-based signatures to identify safe potent hits against Mycobacteria.

J Chem Inf Model 2020 Jul 2. Epub 2020 Jul 2.

Development of new potent, safe drugs to treat Mycobacteria has proven to be challenging, with limited hit rates of initial screens restricting subsequent development efforts. Despite significant efforts and evolution of Quantitative Structure-Activity Relationship (QSAR) as well as machine learning-based models for computationally predicting molecule bioactivity, there is an unmet need for efficient and reliable methods for identifying biologically active compounds against mycobacterium that are also safe for humans. Here we have developed mycoCSM, a graph-based signature approach to rapidly identify compounds likely to be active against bacteria from the genus Mycobacterium, or against specific Mycobacteria species. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acs.jcim.0c00362DOI Listing

Allyl piperidine -1-carbodiothioate and benzyl 1H-imidazole 1 carbodithioate: two potential agents to combat against mycobacteria.

J Appl Microbiol 2020 Jul 2. Epub 2020 Jul 2.

University of Calcutta, Microbiology, Kolkata, West Bengal, India.

Specific Aims: The emergence of multidrug resistant strains of Mycobacterium tuberculosis has made tuberculosis more difficult to manage clinically. With the aim of obtaining new and effective anti-mycobacterial agent(s), this study investigated the anti-mycobacterial activity of several imidazole and piperidine derivatives.

Methods And Results: Towards obtaining new anti-mycobacterial agents, Mycobacterium smegmatis cells were treated with different compounds for their growth inhibitory activity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jam.14762DOI Listing

HIV prevalence and the cascade of care in five South African correctional facilities.

PLoS One 2020 2;15(7):e0235178. Epub 2020 Jul 2.

The Aurum Institute, Johannesburg, South Africa.

Background: South Africa is home to the world's largest HIV epidemic. Throughout the world, incarcerated individuals have a higher prevalence of HIV than the general public, and South Africa has one of the highest rates of incarceration in sub-Saharan Africa. In spite of this, little has been published about the burden of HIV and how care is delivered in South African correctional facilities. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235178PLOS

Tuberculin skin test positivity among HIV-infected alcohol drinkers on antiretrovirals in south-western Uganda.

PLoS One 2020 2;15(7):e0235261. Epub 2020 Jul 2.

Department of Medicine, University of California San Francisco, San Francisco, California, United States of America.

Background: Tuberculosis (TB) is the leading cause of death among people living with HIV (PLWH), and current evidence suggests that heavy alcohol users have an increased risk of developing TB disease compared to non-drinkers. Not known is whether the increased risk for TB disease among alcohol users may reflect higher rates of latent TB infection (LTBI) among this population. We assessed the latent TB infection prevalence based on tuberculin skin testing (TST) and examined association with current alcohol use among HIV-infected persons on antiretroviral therapy (ART) in south-western Uganda. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235261PLOS

Bayesian hierarchical modeling of joint spatiotemporal risk patterns for Human Immunodeficiency Virus (HIV) and Tuberculosis (TB) in Kenya.

PLoS One 2020 2;15(7):e0234456. Epub 2020 Jul 2.

School of Mathematics, Statistics & Computer Science, University of KwaZulu Natal, Pietermaritzburg, South Africa.

The simultaneous spatiotemporal modeling of multiple related diseases strengthens inferences by borrowing information between related diseases. Numerous research contributions to spatiotemporal modeling approaches exhibit their strengths differently with increasing complexity. However, contributions that combine spatiotemporal approaches to modeling of multiple diseases simultaneously are not so common. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234456PLOS

Does mass drug administration affect Schistosoma mansoni infection trends in West Dembia district, Northwest Ethiopia?

J Infect Dev Ctries 2020 Jun 29;14(6.1):72S-77S. Epub 2020 Jun 29.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Introduction: Schistosomiasis is one of the Neglected Tropical Diseases in Ethiopia. Since 2015, yearly school-based mass drug administration (MDA) using praziquantel has become the major control strategy. This study aimed to assess trends of Schistosoma mansoni infection in a high-endemic area in Northwest Ethiopia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3855/jidc.11727DOI Listing

Diagnostic sensitivity of direct wet mount microscopy for soil-transmitted helminth infections in Jimma Town, Ethiopia.

J Infect Dev Ctries 2020 Jun 29;14(6.1):66S-71S. Epub 2020 Jun 29.

Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.

Introduction: Soil-transmitted helminthiasis (STH) remains a major public health problem in school children in Ethiopia. Although direct wet mount microscopy (DWMM) is the means to diagnose parasitic diseases in health care facilities in Ethiopia, it remains unclear what its diagnostic performance is for STH.

Methodology: A cross-sectional study was performed in Jimma Town (Ethiopia) and included 600 children from 10 primary schools. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3855/jidc.11733DOI Listing