250,120 results match your criteria Tuberculosis


Treatment cure rate and its predictors among children with severe acute malnutrition in northwest Ethiopia: A retrospective record review.

PLoS One 2019 20;14(2):e0211628. Epub 2019 Feb 20.

Faculty of Medicine, The University of Queensland, Brisbane, Australia.

Background: More than 29 million that is an estimated 5%, under-five children suffer from severe acute malnutrition (SAM) globally, with a nine times higher risk of mortality than that of well-nourished children. However, little is known regarding outcomes and predictors of SAM in Ethiopia. Therefore, this study aims to determine treatment cure rate and its predictors among children aged 6-59 months with SAM admitted to a stabilization center. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211628PLOS
February 2019

Genetic diversity of Mycobacterium tuberculosis complex strains isolated from livestock workers and cattle in Nigeria.

PLoS One 2019 20;14(2):e0211637. Epub 2019 Feb 20.

Department of Veterinary Public Health and Preventive Medicine, University of Ibadan, Ibadan, Nigeria.

Molecular typing techniques are useful in understanding tuberculosis epidemiology; yet, they have been under-utilised at the human-animal interface in Nigeria. Sixty-four Mycobacterium tuberculosis complex (MTBC) isolates including 42 M. tuberculosis, 13 M. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211637PLOS
February 2019

Non-communicable diseases and tuberculosis: Anticipating the impending global storm.

Glob Public Health 2019 Feb 20:1-10. Epub 2019 Feb 20.

e Medecins du Monde , Athens , Greece.

The epidemiological transitions that have occurred in low and middle income countries (LMIC) during the past decades have led to an increased prevalence on non-communicable diseases (NCDs) in these countries, where the burden of infectious diseases (IDs), especially tuberculosis (TB), remains high. Although the true dimensions of this comorbidity have not yet been fully understood, there is a growing amount of data, over the last 10 years, that suggest a clear association between NCDs and TB. In particular, there is a continuously increasing body of evidence that diabetes mellitus, chronic respiratory conditions, tobacco use, mental health illnesses and chronic kidney disease increase TB morbidity and mortality and vice versa. Read More

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http://dx.doi.org/10.1080/17441692.2019.1580760DOI Listing
February 2019

Robustness of the Line Probe Assay for the Rapid Diagnosis and Characterization of Mutations in Extensively Drug-Resistant Tuberculosis.

Microb Drug Resist 2019 Feb 20. Epub 2019 Feb 20.

4 Department of Microbiology, CMC Vellore, Vellore, Tamil Nadu, India.

Introduction: Extensively drug-resistant tuberculosis (XDRTB) is a public health concern. We evaluated the diagnostic accuracy of Genotype MTBDRsl for detection of resistance to fluoroquinolones (FQs) and second-line injectable drugs (SLIDs) and characterized mutations seen.

Materials And Methods: MTBDRsl was carried out either directly on sputum samples or indirectly on culture isolates (n = 100) from known multidrug-resistant tuberculosis (MDRTB) patients from July 2015 to September 2017. Read More

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http://dx.doi.org/10.1089/mdr.2018.0268DOI Listing
February 2019

Remodeling of the binding site of nucleoside diphosphate kinase revealed by X-Ray structure and H/D exchange.

Biochemistry 2019 Feb 20. Epub 2019 Feb 20.

In order to be fully active and participate in the metabolism of phosphorylated nucleotides, most nucleoside diphosphate kinases (NDPK) have to assemble into stable hexamers. Here we studied the role played by six inter-subunit salt bridges R80-D93 in the stability of NDPK from the pathogen Mycobacterium tuberculosis ( Mt). Mutating R80 into Ala or Asn abolished the salt bridges. Read More

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http://dx.doi.org/10.1021/acs.biochem.8b01308DOI Listing
February 2019

Rifampicin Nanoformulation Enhances Treatment of Tuberculosis in Zebrafish.

Biomacromolecules 2019 Feb 20. Epub 2019 Feb 20.

Mycobacterium tuberculosis, the etiologic agent of tuberculosis, is an intracellular pathogen of alveolar macrophages. These cells avidly take up nanoparticles, even without the use of specific targeting ligands, making the use of nanotherapeutics ideal for the treatment of such infections. Methoxy poly(ethylene oxide)-block-poly(ε-caprolactone) nanoparticles of several different polymer blocks' molecular weights and sizes (20-110 nm) were developed and critically compared as carriers for rifampicin, a cornerstone in tuberculosis therapy. Read More

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http://dx.doi.org/10.1021/acs.biomac.9b00214DOI Listing
February 2019

Vindoline effectively ameliorated diabetes-induced hepatotoxicity by docking oxidative stress, inflammation and hypertriglyceridemia in type 2 diabetes-induced male Wistar rats.

Biomed Pharmacother 2019 Feb 20;112:108638. Epub 2019 Feb 20.

Department of Biomedical Sciences, Phytomedicine and Phytochemistry Research Group, Oxidative Stress Research Centre, Faculty of Health & Wellness Sciences, Cape Peninsula University of Technology, P.O. Box 1906, Bellville, 7535, South Africa. Electronic address:

Vindoline, an indole alkaloid present in the leaves of Catharanthus roseus plant, has been recently reported to have insulotropic effects. This present study evaluated the possible hepatoprotective effects of vindoline in a type 2 diabetes mellitus rat model. Diabetes mellitus was induced by exposing rats to 10% fructose water for two weeks followed by a single intraperitoneal injection of 40 mg/kg body weight of streptozotocin (STZ). Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108638DOI Listing
February 2019

Simultaneous determination of the potent anti-tuberculosis regimen-Pyrazinamide, ethambutol, protionamide, clofazimine in beagle dog plasma using LC-MS/MS method coupled with 96-well format plate.

J Pharm Biomed Anal 2019 Feb 6;168:44-54. Epub 2019 Feb 6.

School of Medicine, Tongji University, No. 1239 Siping Road, Shanghai 200092, PR China; Department of Pharmaceutical Analysis, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China; Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy, Second Military Medical University, No. 325 Guohe Road, Shanghai 200433, PR China; Department of Clinical Pharmacy, Shanghai General Hospital, Shanghai Jiaotong University, No. 100 Haining Road, Shanghai 200025, PR China. Electronic address:

Tuberculosis is one of the top concerns in the world and acutely threatens human health. A new potent candidate regimen containing pyrazinamide (PZA), ethambutol (EMB), protionamide (PTO) and clofazimine (CFZ) was proposed by Parabolic Response Surface/Feedback System Control (FSC/PRS) system and showed excellent outcomes in vitro and vivo studies. Here, a convenient liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) method was developed for the simultaneously determination of four compounds in beagle dog plasma. Read More

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http://dx.doi.org/10.1016/j.jpba.2019.02.006DOI Listing
February 2019

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2.

Eur J Med Chem 2019 Feb 10;167:426-438. Epub 2019 Feb 10.

Univ. Lille, Inserm, Institut Pasteur de Lille, U1177 - Drugs and Molecules for Living Systems, F-59000, Lille, France.

Tuberculosis (TB) caused by the pathogen Mycobacterium tuberculosis, represents one of the most challenging threat to public health worldwide, and with the increasing resistance to approved TB drugs, it is needed to develop new strategies to address this issue. Ethionamide is one of the most widely used drugs for the treatment of multidrug-resistant TB. It is a prodrug that requires activation by mycobacterial monooxygenases to inhibit the enoyl-ACP reductase InhA, which is involved in mycolic acid biosynthesis. Read More

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http://dx.doi.org/10.1016/j.ejmech.2019.02.023DOI Listing
February 2019

Phenylethanoid glycosides of Phlomis younghusbandii Mukerjee ameliorate acute hypobaric hypoxia-induced brain impairment in rats.

Mol Immunol 2019 Feb 20;108:81-88. Epub 2019 Feb 20.

Department of Pharmacy, Shaanxi Provincial Hospital of Tuberculosis Prevention and Treatment, Xi'an 710100, PR China. Electronic address:

High altitude cerebral edema (HACE), whose development process is associated with oxidative stress and inflammatory response, is a life-threatening condition caused by rapid ascent speed to high altitudes. Phenylethanoid glycosides (PhGCs) are primary active constituents isolated from Phlomis younghusbandii Mukerjee that reportedly exhibit potent anti-oxidant and anti-inflammatory activities. The present study aims to investigate the protective effect of phenylethanoid glycosides (PhGCs) from P. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.02.002DOI Listing
February 2019

Household contact investigation for the detection of tuberculosis in Vietnam: economic evaluation of a cluster-randomised trial.

Lancet Glob Health 2019 Mar;7(3):e376-e384

Faculty of Medicine and Health, University of Sydney, NSW, Australia; Woolcock Institute of Medical Research, Glebe, NSW, Australia.

Background: Active case finding is recommended as an important strategy to control tuberculosis, particularly in low-income and middle-income countries with a high prevalence of the disease. However, the costs and cost-effectiveness of active case finding are unclear due to the absence of evidence from randomised trials. We assessed the costs and cost-effectiveness of an active case finding strategy in Vietnam, where there is a high prevalence of tuberculosis. Read More

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http://dx.doi.org/10.1016/S2214-109X(18)30520-5DOI Listing

Active case finding in tuberculosis-affected households: time to scale up.

Lancet Glob Health 2019 Mar;7(3):e296-e298

Department of Global Health and Population, Harvard T H Chan School of Public Health, Boston, MA, USA.

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http://dx.doi.org/10.1016/S2214-109X(19)30015-4DOI Listing

Safety profile of baricitinib in Japanese patients with active rheumatoid arthritis with over 1.6 years median time in treatment: an integrated analysis of Phase 2 and 3 trials.

Mod Rheumatol 2019 Feb 20:1-23. Epub 2019 Feb 20.

g First Department of Internal Medicine , School of Medicine, University of Occupational and Environmental Health , Kitakyushu , Japan.

Objectives: Baricitinib is a selective oral inhibitor of JAK1/JAK2 for patients with moderately-to-severely active rheumatoid arthritis (RA). Baricitinib's safety profile in Japanese patients was evaluated using 6 studies (5 Ph2/Ph3 trials, 1 long-term extension study thru 01-Sept-2016) from an integrated database (9 RA studies).

Methods: Incidence rates (IRs) or exposure-adjusted IRs (EAIRs) of adverse events (AEs) per 100 patient-years (PY) were calculated using data which included RA patients exposed to any baricitinib dose. Read More

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http://dx.doi.org/10.1080/14397595.2019.1583711DOI Listing
February 2019

Primary Tubercular Sialadenitis - A Diagnostic Dilemma.

Iran J Otorhinolaryngol 2019 Jan;31(102):45-50

Department of Otorhinolaryngology, Seth G.S Medical College and KEM Hospital, Mumbai, India.

Introduction: Involvement of the salivary glands in tuberculosis is rare, even in countries where tuberculosis is endemic. It can occur by systemic dissemination from a distant focus or, less commonly, as primary involvement. This article focuses on its myriad clinical presentations that pose a diagnostic challenge to the clinician. Read More

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January 2019

Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis.

Mucosal Immunol 2019 Feb 19. Epub 2019 Feb 19.

Meakins-Christie Laboratories, Department of Medicine, Department of Pathology, McGill University Health Centre, Montreal, QC, H4A 3J1, Canada.

Current treatments for tuberculosis (TB) are effective in controlling Mycobacterium tuberculosis (Mtb) growth, yet have significant side effects and do not prevent reinfection. Therefore, it is critical to understand why our host defense system is unable to generate permanent immunity to Mtb despite prolonged anti-tuberculosis therapy (ATT). Here, we demonstrate that treatment of mice with the most widely used anti-TB drugs, rifampicin (RIF) or isoniazid (INH) and pyrazinamide (PYZ), significantly altered the composition of the gut microbiota. Read More

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http://dx.doi.org/10.1038/s41385-019-0147-3DOI Listing
February 2019

Assessing Molecular Epidemiology of Carbapenem-resistant Klebsiella pneumoniae (CR-KP) with MLST and MALDI-TOF in Central China.

Sci Rep 2019 Feb 19;9(1):2271. Epub 2019 Feb 19.

Infection Control Center, Xiangya Hospital of Central South University, Changsha, Hunan Province, China.

Carbapenem-resistant K. pneumoniae (CR-KP) posts significant public health challenge worldwide. The aim of this study is to assess clinical characteristics and molecular epidemiology of CR-KP infections with Multilocus sequence typing (MLST) and Matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) in Central China. Read More

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http://dx.doi.org/10.1038/s41598-018-38295-8DOI Listing
February 2019

Evaluation of saliva as a potential alternative sampling matrix for therapeutic drug monitoring of levofloxacin in MDR-TB patients.

Antimicrob Agents Chemother 2019 Feb 19. Epub 2019 Feb 19.

University of Groningen, University Medical Center Groningen, Department of Clinical Pharmacy and Pharmacology, Groningen, The Netherlands

Saliva may be a useful alternative matrix for monitoring levofloxacin concentrations in multi-drug resistant TB patients. The objectives of this study were: a) to evaluate the correlation between plasma and salivary Lfx concentrations in MDR-TB patients; and b) to gauge the possibility of using saliva as an alternative sampling matrix for therapeutic drug monitoring of Lfx in TB endemic areas. This was a prospective pharmacokinetic study that enrolled MDR-TB patients receiving levofloxacin (Lfx; 750-1000mg once daily dosing) under standardized treatment regimen in Nepal. Read More

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http://dx.doi.org/10.1128/AAC.02379-18DOI Listing
February 2019

and activities of the riminophenazine TBI-166 against .

Antimicrob Agents Chemother 2019 Feb 19. Epub 2019 Feb 19.

Beijing Key Laboratory of Drug Resistance Tuberculosis Research, Beijing Tuberculosis and Thoracic Tumor Research Institute, and Beijing Chest Hospital, Capital Medical University, Beijing, China

The riminophenazine agent clofazimine (CFZ) is repurposed as an important component of the new short-course multidrug-resistant tuberculosis regimen and significantly shortens first-line regimen for drug-susceptible tuberculosis in mice. However, CFZ use is hampered by its unwelcome skin discoloration in patients. A new riminophenazine analog TBI-166 was selected as a potential next-generation antituberculosis riminophenazine following an extensive medicinal chemistry effort. Read More

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http://dx.doi.org/10.1128/AAC.02155-18DOI Listing
February 2019

Tuberculosis notification in a private tertiary care teaching hospital in South India: a mixed-methods study.

BMJ Open 2019 Feb 19;9(2):e023910. Epub 2019 Feb 19.

Department of Community Health, St John's National Academy of Health Sciences, Bengaluru, Karnataka, India.

Objectives: India contributes approximately 25% of the 'missing' cases of tuberculosis (TB) globally. Even though ~50% of patients with TB are diagnosed and treated within India's private sector, few are notified to the public healthcare system. India's TB notification policy mandates that all patients with TB are notified through Nikshay (TB notification portal). Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02391
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http://dx.doi.org/10.1136/bmjopen-2018-023910DOI Listing
February 2019
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Knowledge and practice of health workers about control and prevention of multidrug-resistant tuberculosis in referral hospitals, Ethiopia: a cross-sectional study.

BMJ Open 2019 Feb 19;9(2):e022948. Epub 2019 Feb 19.

Institute of Public Health, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.

Objective: The aim of this study was to assess the knowledge and practice of health workers about multidrug-resistant tuberculosis (MDR-TB) prevention and control.

Study Design And Settings: A cross-sectional study was conducted at Gondar University Referral Hospital and Felege Hiwot Referral Hospital.

Participants: Randomly selected health workers (ie, medical doctor, nurse, health officer, pharmacy, medical laboratory and midwifery) were the study participants. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-022948DOI Listing
February 2019

Turbine enzyme's structure in the crosshairs to target tuberculosis.

Authors:
Thomas M Duncan

Proc Natl Acad Sci U S A 2019 Feb 19. Epub 2019 Feb 19.

Department of Biochemistry and Molecular Biology, State University of New York Upstate Medical University, Syracuse, NY 13210

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http://dx.doi.org/10.1073/pnas.1900798116DOI Listing
February 2019

Immigrant screening for latent tuberculosis infection: numbers needed to test and treat, a Norwegian population-based cohort study.

BMJ Open 2019 Jan 17;9(1):e023412. Epub 2019 Jan 17.

Department of Tuberculosis, Blood-Borne and Sexually Transmitted Infections, Norwegian Institute of Public Health, Oslo, Norway.

Objectives: To estimate the number needed to screen (NNS) and the number needed to treat (NNT) to prevent one tuberculosis (TB) case in the Norwegian immigrant latent tuberculosis infection (LTBI) screening programme and to explore the effect of delay of LTBI treatment initiation.

Design: Population-based, prospective cohort study.

Participants: Immigrants to Norway. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023412DOI Listing
January 2019

Successful control of exacerbation of Allergic Bronchopulmonary Aspergillosis due to Aspergillus terreus in a cystic fibrosis patient with short-term adjunctive therapy with voriconazole: A case report.

J Mycol Med 2019 Feb 16. Epub 2019 Feb 16.

Invasive Fungi Research Center (IFRC)/ Department of Medical Mycology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Electronic address:

A 12-year-old boy with cystic fibrosis (CF) and a history of glucocorticoid-dependent allergic bronchopulmonary aspergillosis (ABPA) was referred to our hospital. The ABPA was diagnosed when he was 8 years old and he had been treated with several course of oral glucocorticoids for recurrent exacerbations. He was readmitted when aged 12 with a history of worsening shortness of breath and chest tightness. Read More

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http://dx.doi.org/10.1016/j.mycmed.2019.02.001DOI Listing
February 2019

MiR-129-3p favors intracellular BCG survival in RAW264.7 cells by inhibiting autophagy via Atg4b.

Cell Immunol 2019 Jan 28. Epub 2019 Jan 28.

Ningxia Key Laboratory of Clinical and Pathogenic Microbiology, General Hospital of Ningxia Medical University, Yinchuan 750004, China; Department of Medical Genetic and Cell Biology, College of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China. Electronic address:

Autophagy plays an important role in the fight against Mycobacterium tuberculosis infection. Massive researches proved that miRNAs could be the regulators of autophagy, which implied miRNAs could favor MTB invasion or latent infection. In our study, multiple bioinformatics databases and software were used to seek and lock the miRNAs associating with regulation of autophagy. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.01.004DOI Listing
January 2019

Ischemic stroke and disseminated tuberculosis in a child living with human immunodeficiency virus: a case report and review of the literature.

J Med Case Rep 2019 Feb 20;13(1):38. Epub 2019 Feb 20.

Department of Pediatrics and Child Health, College of Health Sciences, Addis Ababa, University, Addis Ababa, Ethiopia.

Background: Cerebrovascular accidents are rare in children. Rates of stroke in children with human immunodeficiency virus infection are higher than in the uninfected population.

Case Presentation: We report the case of a 19-month-old Ethiopian boy who presented with a left-sided body weakness of sudden onset. Read More

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http://dx.doi.org/10.1186/s13256-019-1990-2DOI Listing
February 2019

Unique temperature patterns in 24-h continuous tympanic temperature in tuberculosis.

Trop Doct 2019 Feb 19:49475519829600. Epub 2019 Feb 19.

5 Professor, Department of Internal Medicine, Kasturba Medical College, Mangaluru, Manipal Academy of Higher Education, Manipal, India.

Body temperature monitoring in most healthcare institutions is limited to checking the presence or absence of fever. Our present study evaluated the 24h continuous tympanic temperature pattern in patients with fever in order to detect typical patterns seen in tuberculosis (TB). This observational study was conducted on 81 undifferentiated fever patients whose recordings were stored using the TherCom device. Read More

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http://dx.doi.org/10.1177/0049475519829600DOI Listing
February 2019

An uncommon case of gall bladder mass: gall bladder tuberculosis.

Trop Doct 2019 Feb 19:49475519829601. Epub 2019 Feb 19.

5 Assistant Professor, Division of Surgical Gastroenterology, Department of General Surgery, PGIMER, Chandigarh, India.

Gall bladder tuberculosis (TB) is a rare entity and differentiation of gall bladder TB from gall bladder malignancy is difficult. We hereby present an unusual case of incidental diagnosis of gall bladder TB during the evaluation of a gall bladder with suspicion of gall bladder cancer in a 49-year-old woman. The diagnosis of gall bladder TB was made with fine needle aspiration cytology (FNAC) from the gall bladder mass as the disease was found unresectable after cross-sectional imaging. Read More

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http://dx.doi.org/10.1177/0049475519829601DOI Listing
February 2019

NEAT1 mediates paclitaxel-resistance of non-small cell of lung cancer through activation of Akt/mTOR signaling pathway.

J Drug Target 2019 Feb 20:1-23. Epub 2019 Feb 20.

c Department of Thoracic Surgery , Zhejiang Hospital , Hangzhou , Zhejiang 310013 , PR China.

Development of paclitaxel-resistance is a main problem during non-small cell lung cancer (NSCLC) chemotherapy. Nuclear paraspeckle assembly transcript 1 (NEAT1) is an oncogenic long non-coding RNA (lncRNA) which has been proved to be aberrantly upregulated in many human malignancies. In this study, we investigated the mechanism by which NEAT1 contributed to paclitaxel-resistance in NSCLC. Read More

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http://dx.doi.org/10.1080/1061186X.2019.1585437DOI Listing
February 2019

Recent advances in aerosolised drug delivery.

Biomed Pharmacother 2019 Feb 16;112:108601. Epub 2019 Feb 16.

Department of pharmaceutics, I.S.F. College of Pharmacy, Moga, Punjab, India. Electronic address:

Pulmonary route is extensively studied for the diagnosis and treatment of pulmonary and extra pulmonary disease conditions such as asthma, tuberculosis, emphysema, and bronchitis. Formulation design, inhalation device and particle size play key role in determining the aerosol performance. The lack of desired clinical outcome along with the problem regarding efficacy or any adverse drug effect may arise due to improper training and education in use of the device to control the actuation and aerosol inhalation. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108601DOI Listing
February 2019

Multiple Machine Learning Comparisons of HIV Cell-Based and Reverse Transcriptase Datasets.

Mol Pharm 2019 Feb 19. Epub 2019 Feb 19.

The human immunodeficiency virus (HIV) causes over a million deaths every year and has a huge economic impact in many countries. The first class of drugs approved were nucleoside reverse transcriptase inhibitors. A newer generation of reverse transcriptase inhibitors have become susceptible to drug resistant strains of HIV, and hence alternatives are urgently needed. Read More

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http://dx.doi.org/10.1021/acs.molpharmaceut.8b01297DOI Listing
February 2019
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Exploring Manifestations of TB-Related Stigma Experienced by Women in Kolkata, India.

Ann Glob Health 2018 Nov 5;84(4):727-735. Epub 2018 Nov 5.

Department of Health Care Organization and Policy, School of Public Health, University of Alabama at Birmingham, Birmingham, US.

Background: Stigma associated with tuberculosis (TB) is still common in many societies, contributing to delays in treatment seeking and treatment non-compliance. India has the highest burden of TB in the world with female TB patients bearing a considerable burden of TB-related stigma. Objectives: This study aimed to explore the manifestations and consequences of stigma experienced by female TB patients in an urban setting in India and their strategies to cope with the social stigma of TB. Read More

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http://dx.doi.org/10.9204/aogh.2383DOI Listing
November 2018

The Influence of Pharmacogenetic Variants in HIV/Tuberculosis Co-infected Patients in Uganda in the SOUTH Study.

Clin Pharmacol Ther 2019 Feb 19. Epub 2019 Feb 19.

Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Unsatisfactory treatment outcomes have been reported in HIV/tuberculosis (TB) co-infected patients. Aim of this study was to assess the influence of single nucleotide polymorphisms (SNPs) in genes encoding for proteins involved in antitubercular drug disposition or effect. A pharmacogenetic study was conducted in Kampala, Uganda, where all analysis were performed. Read More

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http://doi.wiley.com/10.1002/cpt.1403
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http://dx.doi.org/10.1002/cpt.1403DOI Listing
February 2019
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Haemophagocytic lymphohistiocytosis secondary to presumed congenital tuberculosis in a neonate.

J Paediatr Child Health 2019 Feb 18. Epub 2019 Feb 18.

Department of Allergy and Immunology, Children's Hospital at Westmead, Sydney, New South Wales, Australia.

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http://dx.doi.org/10.1111/jpc.14393DOI Listing
February 2019

A single-shot diagnostic platform based on copper nanoclusters coated with cetyl trimethylammonium bromide for determination of carbamazepine in exhaled breath condensate.

Mikrochim Acta 2019 Feb 18;186(3):194. Epub 2019 Feb 18.

Pharmaceutical Analysis Research Center and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, 51664, Iran.

A fluorescent nanoprobe is designed for the determination of carbamazepine (CBZ) in exhaled breath condensate (EBC) of patients receiving CBZ. The probe consists of copper nanoclusters (Cu NCs) coated with cetyl trimethylammonium bromide. The interaction of probe with CBZ results in blocking non-radiative e/h recombination defect sites on the surface of Cu NCs and consequently enhancing the blue-green fluorescence of Cu NCs (excitation/emission wavelengths: 290/480 nm). Read More

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http://dx.doi.org/10.1007/s00604-019-3278-zDOI Listing
February 2019

Selective delipidation of Mycobacterium bovis BCG enables direct pulmonary vaccination and enhances protection against Mycobacterium tuberculosis.

Mucosal Immunol 2019 Feb 18. Epub 2019 Feb 18.

Texas Biomedical Research Institute, San Antonio, TX, 78227, USA.

Mycobacterium tuberculosis (M.tb), the causative agent of tuberculosis (TB), is the leading killer due to an infectious organism. Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only vaccine approved against TB, however, its efficacy against pulmonary TB is poor. Read More

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http://dx.doi.org/10.1038/s41385-019-0148-2DOI Listing
February 2019

Association of PXR and CAR Polymorphisms and Antituberculosis Drug-Induced Hepatotoxicity.

Sci Rep 2019 Feb 18;9(1):2217. Epub 2019 Feb 18.

Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

A combination therapy of multiple drugs including isoniazid, rifampicin, ethambutol and pyrazinamide has been proven to be an effective option for the vast majority of tuberculosis (TB) patients. However, various adverse drug reactions (ADRs) limit its merit, with anti-TB drug-induced hepatotoxicity (ATDH) being a common and sometimes severe ADR. This study aimed to investigate the association between polymorphisms in two nuclear receptor genes, pregnane X receptor (PXR) and constitutive androstane receptor (CAR), and the risk of ATDH in a Chinese population. Read More

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http://dx.doi.org/10.1038/s41598-018-38452-zDOI Listing
February 2019

Presumed tubercular choroidal nodule following adalimumab therapy for juvenile idiopathic arthritis.

Indian J Ophthalmol 2019 Mar;67(3):399-400

Department of Uvea Ocular Pathology, Medical and Vision Research Foundations, Sankara Nethralaya, Chennai, Tamil Nadu, India.

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http://dx.doi.org/10.4103/ijo.IJO_1149_18DOI Listing

Enigma of serpiginous choroiditis.

Indian J Ophthalmol 2019 Mar;67(3):325-333

Advanced Eye Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Serpiginous choroiditis (SC) is an asymmetrically bilateral inflammation of the choroid that leads to loss of choriocapillaris atrophy or loss of overlying retinal pigment epithelium. Over the last few decades, SC has passed through a long evolution of nomenclature, etiologies and morphological variations. Initially diagnosed in patients with tuberculosis and syphilis, SC was predominantly considered as autoimmune process. Read More

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http://dx.doi.org/10.4103/ijo.IJO_822_18DOI Listing

Toward Developing a Standardized Core Set of Outcome Measures in Mobile Health Interventions for Tuberculosis Management: Systematic Review.

JMIR Mhealth Uhealth 2019 Feb 19;7(2):e12385. Epub 2019 Feb 19.

Department of Public Health Sciences, Graduate School of Public Health, Seoul National University, Seoul, Republic of Korea.

Background: Tuberculosis (TB) management can be challenging in low- and middle-income countries (LMICs) not only because of its high burden but also the prolonged treatment period involving multiple drugs. With rapid development in mobile technology, mobile health (mHealth) interventions or using a mobile device for TB management has gained popularity. Despite the potential usefulness of mHealth interventions for TB, few studies have quantitatively synthesized evidence on its effectiveness, presumably because of variability in outcome measures reported in the literature. Read More

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http://dx.doi.org/10.2196/12385DOI Listing
February 2019

Virology Tests in Brain-Dead Donors: Let the Bills Run Up?

Exp Clin Transplant 2019 Jan;17(Suppl 1):260-263

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: In the organ donation process, screening for serologic markers for a selection of agents is essential to prevent infection transmission. The screening of donors for specific potential infections can never absolutely exclude the risk of transmission. For reevaluation of serology tests, we analyzed results of tests requested for all brain-dead donors. Read More

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http://www.ectrx.org/forms/ectrxcontentshow.php?doi_id=10.60
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http://dx.doi.org/10.6002/ect.MESOT2018.P114DOI Listing
January 2019
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Role of Methylprednisolone in the Management of Hemodynamically Unstable Brain-Dead Cases.

Exp Clin Transplant 2019 Jan;17(Suppl 1):257-259

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Optimal care of potential donors can lead to successful transplantation. Hemodynamic instability is a common complication in deceased potential donors. The most common underlying causes are hormonal and electrolyte disturbances as well as a hyperinflammatory state, which is rooted in activation of the cytokine cascade. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P113DOI Listing
January 2019

Liver Donation From Marginal Donors: To Donate or Not to Donate?

Exp Clin Transplant 2019 Jan;17(Suppl 1):254-256

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Livers from deceased donors compose nearly 30% of all organ transplants, and about 700 liver transplants are carried out per year. Marginal livers (extended-criteria donors), however, are not usually accepted by recipient teams, and there is only one center for these procedures in Iran. The final decision is made according to criteria that are much more conservative than other globally accepted ones. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P112DOI Listing
January 2019

Demographic Differences Between Two 7-Year Periods of Organ Donation in Iran: A Single-Center Experience.

Exp Clin Transplant 2019 Jan;17(Suppl 1):242-245

From the Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Donor characteristics can directly affect transplant outcomes. In this study, we examined donor patterns in an organ procurement unit, which covered one-third of the population in Tehran, Iran over the past 12 years (2005 to 2018).

Materials And Methods: Demographic data of donors, including sex, age, cause of death, blood group, outcome of donation, number of organs per donor, and comorbidities (including diabetes mellitus and hypertension), were assessed. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P106DOI Listing
January 2019

Frequencies of Common Infectious Organisms Causing Chronic Diarrhea in Renal Transplant Patients.

Exp Clin Transplant 2019 Jan;17(Suppl 1):212-215

From the Department of Hepatogastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Objectives: Gastrointestinal complications are common in kidney transplant patients, with the most frequent being diarrhea (60%). Chronic diarrhea affects the patient's quality of life, causes fatigue and weight loss and malabsorption, increases the number of hospitalizations, increases serum creatinine levels, and causes alterations in immunosuppressive drug levels. Diarrhea is also associated with an increased risk of graft failure and death. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.P69DOI Listing
January 2019

Failed Organ Donations After Transfer to an Organ Procurement Unit.

Exp Clin Transplant 2019 Jan;17(Suppl 1):128-130

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: In Iran, each medical university can have one organ procurement unit for its own hospital. If the family consents, all patients with brain death must be transferred to the organ procurement unit. When brain death is officially confirmed and the family gives the second consent, the organs are then retrieved in the operating room. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O79DOI Listing
January 2019

Reasons for Donor Lungs Unsuitability After Radiographic Selection.

Exp Clin Transplant 2019 Jan;17(Suppl 1):120-122

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran.

Objectives: Deceased lung donation requires optimum donor care, with lung viability greatly affected by the progress of the disease leading to brain death. In this study, we searched for causes of lung unsuitability for transplant in both primary and secondary evaluations.

Materials And Methods: Primary lung evaluations included chest radiography, oxygen challenge test, and donor clinical and history examination. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O62DOI Listing
January 2019

Consequences of More Coordinator Engagement to Take Consent for Organ Donation: Comparisons of New Versus Experienced Staff.

Exp Clin Transplant 2019 Jan;17(Suppl 1):110-112

From the Organ Procurement Unit (OPU), Lung Transplantation Research Center (LTRC), National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences (SBMU), Darabad, Niavaran, Tehran 19569-44413, Iran.

Objectives: The method of obtaining family consent for organ donation after occurrence of brain death in Iran is an opt-in process. Because of complicated cultural, legal, religious, and familial structures in Iran, it is not simple to take consent for organ donation in brain death situations. The process needs the professional staff to be experienced and have an appropriate personality to obtain consent. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O50DOI Listing
January 2019

Renal Transplant and Its Outcomes: Single-Center Experience From India.

Exp Clin Transplant 2019 Jan;17(Suppl 1):78-82

From the Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Improvements in early graft survival and long-term graft function have made kidney transplant a more cost-effective alternative to dialysis. We aimed to assess renal transplant outcomes over a 9-month follow-up of recipients in a cost-limited setting (a tertiary care center in India).

Materials And Methods: Included patients in this prospective observational study were those who underwent renal transplant from July 2016 to February 2017 (8 months) and followed for 9 months. Read More

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http://dx.doi.org/10.6002/ect.MESOT2018.O14DOI Listing
January 2019

Nontuberculous mycobacteria in cervical lymphadenopathies of HIV positive and HIV-negative adults

Rev Med Inst Mex Seguro Soc 2019 Jan 28;56(5):456-461. Epub 2019 Jan 28.

Secretaría de Salud, Hospital General de México “Dr. Eduardo Liceaga”, Unidad de Neumología y Cirugía de Tórax. Ciudad de México, México

Background: Tuberculosis is a global public health problem, especially in emerging countries. Mycobacterium tuberculosis is the main cause of cervical lymphadenopathy; nontuberculous mycobacteria are relatively common in children and rare in adults.

Objective: To identify and establish the frequency of infectious etiology by nontuberculous mycobacteria in Mexican adult patients with cervical lymphadenopathy. Read More

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January 2019

The death of Charlotte Brontë from hyperemesis gravidarum and refeeding syndrome: A new perspective.

Clin Nutr 2019 Feb 10. Epub 2019 Feb 10.

Gastrointestinal Surgery, Nottingham Digestive Diseases Centre and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK; MRC/ARUK Centre for Musculoskeletal Ageing Research, School of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UK, UK. Electronic address:

Many theories have been advanced concerning the cause of Charlotte Brontë's death, none of which fully explain all the symptoms she experienced in the course of her final illness. Her death certificate records the cause of death as phthisis (tuberculosis), but there is no evidence, other than circumstantial, to support this diagnosis. A diagnosis of Addison's disease, caused by tuberculosis of the adrenals, has been proposed, but this is unlikely, since it does not fit well with two and a half months of severe anorexia, nausea and vomiting, followed by remission of these symptoms and eventual death. Read More

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http://dx.doi.org/10.1016/j.clnu.2019.01.027DOI Listing
February 2019