164,272 results match your criteria Tube Thoracostomy

Infections and patterns of antibiotic utilization in support and comfort care patients: A tertiary care center experience.

J Infect Public Health 2021 May 26;14(7):839-844. Epub 2021 May 26.

Department of Health Informatics, CPHHI, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia; Data and Business Intelligence Management Department, ISID, King Abdulaziz Medical City, Riyadh, Saudi Arabia.

Purpose: Little is known regarding the burden of infections and clinical practice towards hospitalized patients with limits on life-sustaining measures. We aim to describe the infectious syndromes, clinical care, the emergence of multi-drug resistant organisms and outcomes in this population.

Patients And Methods: Retrospective cohort of patients labeled as support or comfort care in a tertiary care center between 2016-2019. Read More

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β3-Endonexin interacts with ninein in vascular endothelial cells to promote angiogenesis.

Biochem Biophys Res Commun 2021 Jun 9;566:75-79. Epub 2021 Jun 9.

School of Environmental and Chemical Engineering, Shanghai University, Shanghai, China; School of Life Sciences, Shanghai University, Shanghai, China; Versiti Blood Research Institute, Milwaukee, WI, USA; Department of Biochemistry, Medical College of Milwaukee, Wisconsin, USA. Electronic address:

Anti-angiogenesis serves as an effective tumor therapy approach. In a previous study, we found that β3-endonexin expressed in vascular endothelial cells was involved in promoting proliferation and angiogenesis partially by facilitating VEGF expression. However, it still remains unclear if β3-endonexin in vascular endothelial cells also employs other mechanisms in regulating angiogenesis. Read More

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Light chain subunit of a poorly soluble human IgG2λ crystallizes in physiological pH environment both in cellulo and in vitro.

Biochim Biophys Acta Mol Cell Res 2021 Jun 9:119078. Epub 2021 Jun 9.

Department of Therapeutic Discovery, Amgen Inc., Thousand Oaks, CA 91320, USA.

Prominent inclusion bodies can develop in the endoplasmic reticulum (ER) when overexpressed antibodies possess intrinsically high condensation propensities. These observations suggest that antibodies deemed to show notable solubility problems may reveal such characteristics preemptively in the form of ER-associated inclusion bodies during antibody overexpression. To define the relationships between solubility problems and inclusion body phenotypes, we investigated the biosynthesis of a model human IgG2λ that shows severe opalescence in an acidic formulation buffer yet retains high solubility at physiological pH. Read More

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Nasogastric Tube Insertion in intubated patients with the guide of Wire rope: A Prospective Randomized Controlled Study.

Int J Clin Pract 2021 Jun 12:e14508. Epub 2021 Jun 12.

Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Nasogastric tube (NGT) insertion is sometimes required in intubated patients. NGTs are prone to kink and coil during blind insertion. We hypothesized that Wire rope guide-assisted NGT insertion with chin lift can significantly improve the first-attempt success rate over the conventional technique during its insertion in intubated patients. Read More

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Fuzuloparib: First Approval.

Arnold Lee

Drugs 2021 Jun 12. Epub 2021 Jun 12.

Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.

Fuzuloparib (AiRuiYi, ; formerly fluzoparib) is a small molecule, orally active PARP inhibitor being developed by Jiangsu Hengrui Pharmaceuticals Co., Ltd. (formerly Jiangsu Hengrui Medicine Co. Read More

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Oxidative formation of bis-N-methylquinolinone from anti-head-to-head N-methylquinolinone cyclodimer.

Photochem Photobiol Sci 2021 Jun 12. Epub 2021 Jun 12.

Department of Chemistry, Philipps-Universität Marburg, Hans-Meerwein-Straße 4, 35032, Marburg, Germany.

The light-driven formation and cleavage of cyclobutane structural motifs resulting from [2 + 2]-pericyclic reactions, as found in thymine and coumarin-type systems, is an important and intensively studied photochemical reaction. Various applications are reported utilizing these systems, among others, in cross-linked polymers, light-triggered drug release, or other technical applications. Herein coumarin is most frequently used as the photoactive group. Read More

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Regenerating Critical Size Rat Segmental Bone Defects with a Self-Healing Hybrid Nanocomposite Hydrogel: Effect of Bone Condition and BMP-2 Incorporation.

Macromol Biosci 2021 Jun 12:e2100088. Epub 2021 Jun 12.

Biomaterials, Radboudumc, Philips van Leijdenlaan 25, Nijmegen, Gelderland, 6525 EX, The Netherlands.

The aim of the current study is to assess the biological performance of self-healing hydrogels based on calcium phosphate (CaP) nanoparticles and bisphosphonate (BP) conjugated hyaluronan (HA) in a critical size segmental femoral bone defect model in rats. Additionally, these hydrogels are loaded with bone morphogenetic protein 2 (BMP-2) and their performance is compared in healthy and osteoporotic bone conditions. Treatment groups comprise internal plate fixation and placement of a PTFE tube containing hydrogel (HA -CaP) or hydrogel loaded with BMP-2 in two dosages (HA -CaP-lowBMP2 or HA -CaP-highBMP2). Read More

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Bicentric evaluation of stabilizing sampling tubes for assessment of monocyte HLA-DR expression in clinical samples.

Cytometry B Clin Cytom 2021 Jun 12. Epub 2021 Jun 12.

Hospices Civils de Lyon, Edouard Herriot Hospital, Immunology Laboratory, Lyon, France.

Background: Diminished expression of human leukocyte antigen DR on circulating monocytes (mHLA-DR), measured by standardized flow cytometry procedure, is a reliable indicator of immunosuppression in severely injured intensive care unit patients. As such, it is used as stratification criteria in clinical trials evaluating novel immunostimulating therapies. Preanalytical constraints relative to the short delay between blood sampling and flow cytometry staining have nevertheless limited its use in multicentric studies. Read More

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Current status of surgical treatment of Boerhaave's syndrome.

Esophagus 2021 Jun 11. Epub 2021 Jun 11.

Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Background: Surgical treatment is usually required for Boerhaave's syndrome (post-emetic esophageal perforation), and the technique should be chosen based on the local infection status and patient's general condition. This study was performed to examine the current status of surgical treatment of Boerhaave's syndrome in Japan.

Methods: Ninety-five patients with Boerhaave's syndrome who underwent surgical treatment from January 2010 to December 2015, obtained from a national survey were retrospectively analyzed. Read More

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Environmental and diagenetic controls on the morphology and calcification of the Ediacaran metazoan Cloudina.

Sci Rep 2021 Jun 11;11(1):12341. Epub 2021 Jun 11.

School of GeoSciences, University of Edinburgh, James Hutton Road, Edinburgh, EH9 3FE, UK.

Cloudina is a globally distributed Ediacaran metazoan, with a tubular, funnel-in-funnel form built of thin laminae (ca. 1-10 μm). To what degree local environmental controlled morphology, and whether early diagenesis controlled the degree of calcification of Cloudina, is debated. Read More

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Factors and Growth Trends Associated with the Need for Gastrostomy Tube in Neonates with Congenital Diaphragmatic Hernia.

J Pediatr Gastroenterol Nutr 2021 Jun 10. Epub 2021 Jun 10.

Division of Pediatric Surgery, University of California San Francisco, CA, USA.

Objectives: A third of infants with congenital diaphragmatic hernia (CDH) require a gastrostomy tube (GT) for nutritional support. We compared CDH infants who are GT-dependent to those able to meet their nutritional needs orally, to identify factors associated with requiring a GT and evaluate their long-term growth.

Methods: Patients with CDH repaired at a single institution between 2012-2020 were included. Read More

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Health Education Intervention for Patients Undergoing Placement of Percutaneous Nephrostomy Tube: A Randomized Controlled Trial.

J Wound Ostomy Continence Nurs 2021 Jun 9. Epub 2021 Jun 9.

Luis Manuel Fernández Cacho, PhD, Department of Radiology, Marqués de Valdecilla University Hospital, IDIVAL, School of Nursing, University of Cantabria, Santander, Spain Rosa Ayesa Arriola, PhD, Department of Psychiatry, Marqués de Valdecilla University Hospital, IDIVAL, School of Medicine, University of Cantabria, Santander, Spain; Centro Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain.

Purpose: The purpose of this study was to compare the economic impact (cost) of percutaneous nephrostomy (PCN) tube care in patients following an educational intervention to no intervention.

Design: A randomized controlled trial.

Subjects And Setting: The sample comprised 178 patients recruited between May 2017 and April 2019. Read More

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Quantitative description of a contractile macromolecular machine.

Sci Adv 2021 Jun 11;7(24). Epub 2021 Jun 11.

Department of Biochemistry and Molecular Biology, Sealy Center for Structural Biology and Molecular Biophysics (SCSB), The University of Texas Medical Branch at Galveston, Galveston, TX 77555, USA.

Contractile injection systems (CISs) [type VI secretion system (T6SS), phage tails, and tailocins] use a contractile sheath-rigid tube machinery to breach cell walls and lipid membranes. The structures of the pre- and postcontraction states of several CISs are known, but the mechanism of contraction remains poorly understood. Combining structural information of the end states of the 12-megadalton R-type pyocin sheath-tube complex with thermodynamic and force spectroscopy analyses and an original modeling procedure, we describe the mechanism of pyocin contraction. Read More

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Impact of coronavirus disease 2019 (COVID-19) on trauma surgical education at a level I trauma center.

Surgery 2021 May 24. Epub 2021 May 24.

Division of Trauma and Critical Care Surgery, Department of Surgery, University of Tennessee Medical Center at Knoxville, TN.

Background: During the coronavirus disease 2019 pandemic, trauma presentations to the emergency room decreased across the country. The goal of this study is to analyze the educational impact of coronavirus disease 2019 on trauma education and training at a level I trauma center.

Methods: Trauma patient presentations were analyzed 6 months before a Tennessee executive stay-at-home order and 6 months after the state executive order. Read More

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Hysteroscopy-assisted laparoscopic salpingectomy for interstitial pregnancy without cornual resection.

Fertil Steril 2021 Jun 8. Epub 2021 Jun 8.

Reproductive Biology Associates, Atlanta, Georgia.

Objective: To illustrate a novel surgical management technique for interstitial ectopic pregnancies (IP).

Design: Video description of the case, demonstration of the surgical technique, reevaluation at the 6-week postoperative follow-up, and review of the advantages of this surgical technique for IP.

Setting: Tertiary referral center. Read More

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Umbilical cord blood hematological parameters reference interval for newborns from Addis Ababa, Ethiopia.

BMC Pediatr 2021 Jun 11;21(1):275. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Several factors like altitude, age, sex, pregnancy, socioeconomic status, life style and race influence hematological reference interval (RIs), which are critical to support clinical decisions and to interpret laboratory data in research. Currently there are no well-established RIs for cord blood hematological parameters of newborns in Ethiopia. This study aims to generate RIs for umbilical cord blood hematological parameters of newborns from Addis Ababa, Ethiopia. Read More

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Establishment and characterization of a rat intestinal microvascular endothelial cell line.

Tissue Cell 2021 Jun 9;72:101573. Epub 2021 Jun 9.

Division of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, 100193, PR China. Electronic address:

Intestinal microvascular endothelial cell (IMVEC) is a fundamental and essential component of gut-vascular barrier which is closely associated with intestinal disorders However, there is still a lack of established intestinal microvascular endothelial cell line. In the present study, a newly established rat intestinal microvascular endothelial cell line termed RIMVEC-11 was described and characterized which has been stably cultured for more than 90 passages so far. RIMVEC-11 was characterized by endothelial features with the cobblestone morphology under light microscopy, the Weibel-Palade body and rich vesicles in the cytoplasm on the ultrastructural level, and positive endothelial specific markers CD31 and von Willebrand factor by immunocytochemistry analysis. Read More

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GAMOS/GEANT4 simulation and comparison study of X-ray narrow-spectrum series at the national Secondary Standard Dosimetry Laboratory of Morocco.

Appl Radiat Isot 2021 May 27;175:109789. Epub 2021 May 27.

LPMS, Faculty of Sciences, University of Ibn Tofail, Kenitra, Morocco.

This study aimed to simulate the X-ray Irradiator narrow-spectrum series and compare the results with experimental and recommended values in ISO standards. X-Ray beam qualities of N-40 to N-300 were established experimentally at the national Secondary Standard Dosimetry Laboratory (SSDL) of Morocco in purpose of calibrating radiation protection- level. The variations between the first half-value layer (1 HVL) and the second (2 HVL) for experimental were within 5%. Read More

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Middle ear effusion prevalence at time of tympanostomy before and during COVID-19 pandemic.

Int J Pediatr Otorhinolaryngol 2021 Jun 8;147:110785. Epub 2021 Jun 8.

Nemours Children's Hospital, Orlando, FL, USA.

Background: Management of pediatric otitis media with effusion (OME) and recurrent otitis media typically includes observation up to 3 months. Bilateral myringotomy and tube (BMT) placement is performed due to persistent effusion with associated symptoms such as decreased hearing. With the COVID-19 pandemic and mandatory stay at home orders (MSHO), children were quarantined at home and many remained home after MSHO. Read More

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Efficacy of an autologous blood patch for prolonged air leak, a systematic review.

Ann Thorac Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Thoracic Surgery, Rijnstate Hospital, Arnhem, the Netherlands; Multi-Modality Medical Imaging Group, TechMed Centre, University of Twente, Enschede, The Netherlands.

Background: Prolonged air leak (PAL) following pulmonary surgery remains a clinical challenge and sometimes needs surgical reintervention. An autologous blood patch (ABP) may provide a noninvasive method to cease air leak. Its value, however, is debatable. Read More

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Improving aeration systems in saline water (part II): effect of different salts and diffuser type on oxygen transfer of fine-bubble aeration systems.

Water Sci Technol 2021 Jun;83(11):2778-2792

Technical University of Darmstadt, Institut IWAR, Franziska-Braun-Str. 7, 64287 Darmstadt, Germany E-mail:

The objective of the present study is to investigate the different effects on the oxygen transfer of fine-bubble aeration systems in saline water. Compared to tap water, oxygen transfer increases due to the inhibition of bubble coalescence. In Part I of the present study, we investigated in laboratory-scale experiments the effect of design of diffuser membrane. Read More

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Closed non-suction drain placement as haematoma and seroma formation preventive measure post-nylon darn surgery for inguinoscrotal hernias in adults.

Hernia 2021 Jun 11. Epub 2021 Jun 11.

Department of Medical Laboratory Sciences, School of Biomedical and Allied Health Sciences, University of Ghana, Korle, Bu, Accra, Ghana.

Purpose: Inguinal hernia is a common male surgical disease. Intervention carries a wide range of complications such as scrotal haematoma and seroma which may require surgical re-intervention or predispose patients to developing infections, pains or feeling of mass. This could lead to long hospital stay. Read More

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Probing the Chiral Domains and Excitonic States in Individual WS Tubes by Second-Harmonic Generation.

Nano Lett 2021 Jun 11. Epub 2021 Jun 11.

State Key Laboratory of Surface Physics, Key Laboratory of Micro and Nano Photonic Structures (MOE), and Department of Physics, Fudan University, Shanghai 200433, People's Republic of China.

Distinct from carbon nanotubes, transition-metal dichalcogenide (TMD) nanotubes are noncentrosymmetric and polar and can exhibit some intriguing phenomena such as nonreciprocal superconductivity, chiral shift current, bulk photovoltaic effect, and exciton-polaritons. However, basic characterizations of individual TMD nanotubes are still quite limited, and much remains unclear about their structural chirality and electronic properties. Here we report an optical second-harmonic generation (SHG) study on multiwalled WS nanotubes on a single-tube level. Read More

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The Pharmacokinetics of Crushed Levetiracetam Tablets Administered to Neonates.

J Trop Pediatr 2021 05;67(2)

Division of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town 7505, South Africa.

Background: Intravenous phenobarbital remains the first-line therapy in the management of neonatal seizures. Shortages of intravenous phenobarbital in South Africa necessitated the addition of oral levetiracetam as part of management of neonatal seizures.

Objective: We evaluated the pharmacokinetics of crushed immediate-release levetiracetam tablets administered to neonates to terminate seizures. Read More

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A role for nebulized tranexamic acid in veno-venous ECMO patients.

J Clin Pharm Ther 2021 Jun 10. Epub 2021 Jun 10.

Division of Pulmonary, Critical Care and Sleep Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.

What Is Known And Objective: Although pulmonary haemorrhage as a complication of ECMO has been well documented, optimal management is not fully elucidated. We describe the role of nebulized tranexamic acid as a therapeutic alternative.

Case Summary: We report a case series of three patients with ARDS on ECMO complicated by pulmonary haemorrhage. Read More

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Commentary on: Advancements in microfluidic systems for the study of female reproductive biology.

Cecily V Bishop

Endocrinology 2021 Jun 11. Epub 2021 Jun 11.

Department of Animal and Rangeland Sciences, Oregon State University, Corvallis, OR.

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A novel screening test for inappropriate shocks due to myopotentials from the subcutaneous implantable cardioverter-defibrillator.

Heart Rhythm O2 2020 Apr 27;1(1):27-34. Epub 2020 Apr 27.

Department of Cardiology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

Background: The subcutaneous implantable cardioverter-defibrillator (S-ICD) is effective in preventing sudden cardiac death. Compared with transvenous ICDs, S-ICDs have a lower rate of inappropriate shocks (IASs) for supraventricular arrhythmias, but such shocks for T-wave oversensing (TWO) and extracardiac myopotentials are more common. No screening tests to identify patients at risk for IAS due to myopotential interference (MPI) currently are available. Read More

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Cannabis Use Is Associated With Recurrence After Primary Spontaneous Pneumothorax.

Front Surg 2021 25;8:668588. Epub 2021 May 25.

Department of Cardiovascular and Thoracic Surgery, Rush University Medical Center, Chicago, IL, United States.

Primary spontaneous pneumothorax (PSP) is a frequently encountered entity that carries a high rate of recurrence. The current study aims to investigate if cannabis use at time of initial PSP is associated with disease recurrence. Patients presenting with PSP between 2010 and 2018 at a single institution were identified. Read More

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circMTO1 sponges microRNA-219a-5p to enhance gallbladder cancer progression via the TGF-β/Smad and EGFR pathways.

Oncol Lett 2021 Jul 27;22(1):563. Epub 2021 May 27.

Department of Hepatobiliary Surgery, Lanzhou No. 2 People's Hospital, Lanzhou, Gansu 730046, P.R. China.

Circular mitochondrial translation optimization 1 homologue (circMTO1) has been reported to regulate the tumorigenesis of different types of cancer; however, the role of circMTO1 in gallbladder cancer (GBC) remains unknown. The present study aimed to identify the potential miRNAs and target genes of circMTO1 during GBC progression, and clarify the regulatory mechanism between circMTO1 and miRNAs or target genes. The present study performed MTT and Transwell assays, and Annexin V staining to assess cell viability, migration and apoptosis, respectively. Read More

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Biocompatibility and Angiogenic Effect of Chitosan/Graphene Oxide Hydrogel Scaffolds on EPCs.

Stem Cells Int 2021 18;2021:5594370. Epub 2021 May 18.

Skeletal Biology Research Center, Department of Oral Maxillofacial Surgery, Harvard School of Dental Medicine, Boston, 02114 MA, USA.

Angiogenesis in the field of tissue engineering has attracted significant attention. Graphene oxide has become a promising nanomaterial in tissue engineering for its unique biochemical properties. Therefore, herein, a series of chitosan (CS)/graphene oxide (GO) hydrogel scaffolds were synthesized by crosslinking CS and GO at different concentrations (0. Read More

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