18,706 results match your criteria Tubal Sterilization


Cost-effectiveness analysis of medical management versus conservative surgery for early tubal pregnancy.

Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.

INSERM, Université Paris-Saclay, Univ. Paris-Sud, UVSQ, Centre de Recherche en Epidémiologie et Santé des Populations, Hôpital Paul Brousse, 16 av Paul Vaillant Couturier, Villejuif, France.

Study Question: Is conservative surgery (laparoscopic salpingotomy) cost-effective, using fertility as the endpoint compared with medical management (Methotrexate) in women with an early tubal pregnancy?

Summary Answer: Conservative surgery appeared slightly, but not statistically significantly, more effective than medical management but also more costly.

What Is Known Already: Women with an early tubal pregnancy treated with medical therapy (Methotrexate) or conservative surgery (laparoscopic salpingotomy) have comparable future intrauterine pregnancy rates by natural conception. Also, cost-minimisation studies have shown that medical therapy was less expensive than conservative surgery, but there is no cost-effectiveness study comparing these two treatments with fertility as the endpoint. Read More

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December 2018

Chronic tubal pregnancy manifesting as a heterogeneous adnexal mass with prominent neovascularization in a woman with a negative serum β-human chorionic gonadotropin level.

J Obstet Gynaecol Res 2018 Dec 6. Epub 2018 Dec 6.

Department of Obstetrics and Gynecology, Gifu Prefectural Tajimi Hospital, Tajimi, Japan.

A 41-year-old woman (gravida 2, para 1) underwent elective termination of pregnancy at approximately 7 weeks of gestation. At 1 month after the elective abortion, she was referred due to abnormal results in a cervical cytological examination. Transvaginal ultrasonography showed a heterogeneous mass of 16 mm in diameter in the left adnexal region. Read More

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December 2018

Unexplained infertility: Is it over-diagnosed and over-treated?

Best Pract Res Clin Obstet Gynaecol 2018 Nov 6;53:20-29. Epub 2018 Oct 6.

Department of Obstetrics and Gynaecology, University of Amsterdam, Amsterdam, the Netherlands.

Unexplained infertility is defined as the absence of conception despite 12 months of unprotected intercourse, not explained by anovulation, poor sperm quality, tubal pathology or any known cause of infertility. The two most applied treatments for unexplained infertility are intra-uterine insemination and in vitro fertilisation. As these treatments do not target a specific mechanism but rather increase the probability of conception as compared to natural conception chances, they should be weighed against the prognosis of natural conception. Read More

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November 2018

Hysteroscopic Placement of Platinum Microinsert in Patients With Hydrosalpinx Before In Vitro Fertilization and Embryo Transfer.

J Minim Invasive Gynecol 2018 Nov 30. Epub 2018 Nov 30.

Reproductive and Genetic Hospital of CITIC-XIANGYA, Changsha, China; Institute of Reproductive and Stem Cell Engineering, Basic Medicine College, Central South University, Changsha, China; Key Laboratory of Reproductive and Stem Cell Engineering, Ministry of Health, Changsha, China. Electronic address:

Study Objective: To investigate the effectiveness of Tornado and Hilal (Cook Medical, Bloomington, Indiana, USA) hysteroscopic proximal tubal occlusion (HPTO) for hydrosalpinx (HX) treatment prior to in vitro fertilization (IVF) and embryo transfer (ET) in patients with dense pelvic adhesions or low ovarian reserve.

Design: Retrospective study of patients treated between May 2014 and May 2016 (Canadian Task Force classification III).

Setting: University-affiliated center. Read More

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November 2018

Sectioning and extensively examining the fimbriated end (SEE-FIM) of the fallopian tube in routine practices, is it worth the effort?

J Obstet Gynaecol Res 2018 Dec 2. Epub 2018 Dec 2.

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aim: To determine the prevalence of fallopian tube high-grade serous carcinoma (HGSC) and to analyze the benefit of the sectioning and extensively examining the fimbriated end (SEE-FIM) protocol.

Methods: Fallopian tubes from 450 patients with risk-reducing salpingo-oophorectomy, or tumor of the ovary, endometrium, fallopian tube or peritoneum were examined using the SEE-FIM protocol. Microscopic tubal pathology and the number of paraffin blocks used were evaluated. Read More

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December 2018

The fallopian tube, "precursor escape" and narrowing the knowledge gap to the origins of high-grade serous carcinoma.

Gynecol Oncol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, United States of America. Electronic address:

Most ovarian carcinomas are high-grade serous carcinomas (HGSC) that contain TP53 mutations, present at advanced stage, and eventually become resistant to chemotherapy. The rapid evolution of this disease has been attributed to an origin in the distal fallopian tube, in the form of serous tubal intraepithelial carcinomas (STICs). This has led to a disease model where malignancy develops first in the tube and spreads to the peritoneum or regional lymph nodes. Read More

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November 2018
2 Reads

Demographic, lifestyle, and reproductive risk factors for ectopic pregnancy.

Fertil Steril 2018 Dec;110(7):1328-1337

Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Objective: To evaluate the relationship between demographic, lifestyle, and reproductive factors and the risk of ectopic pregnancy (EP).

Design: Prospective cohort.

Setting: United States. Read More

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December 2018

Ovarian Function In Adolescents Conceived By Assisted Reproductive Technologies.

J Pediatr Adolesc Gynecol 2018 Nov 28. Epub 2018 Nov 28.

Institute of Maternal and Child Research, School of Medicine, University of Chile.

Study Objective: To compare ovarian function between adolescents conceived using assisted reproductive technology (AcART) and adolescents who were conceived spontaneously (AcSP).

Design: Multicenter study of ovarian function in AcART due to male or tubal infertility.

Setting: University Hospital PARTICIPANTS: We evaluated 22 AcART and 53 AcSP at 1-2 years after menarche. Read More

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November 2018

Evaluation of ovarian cancer risk in granulosa cells treated with steroid-depleted endometriosis serum: Role of NF-κB/RelA and AKT.

J Cell Physiol 2018 Dec 4. Epub 2018 Dec 4.

Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Despite at the beginning known as a benign disease, endometriosis is defined as a risk factor for developing ovarian carcinoma. The effect of endometriosis on ovarian malignancy is known but its role in granulosa cell tumor is still unclear.

Methods And Materials: In this study, serum samples were collected from patients with endometriosis and divided into whole and steroid-depleted groups. Read More

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December 2018
1 Read

The isolated tubal torsion: an insidious pediatric and adolescent pelvic urgency.

Pediatr Med Chir 2018 Dec 4;40(2). Epub 2018 Dec 4.

Pediatric Surgery Unit, Salesi Children Hospital, Ancona.

Isolated tubal torsion (ITT) is a rare cause of acute abdominal pain. Preoperative diagnosis is difficult because of a lack of specific signs. Surgery is recommended to preserve the integrity of the tube. Read More

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December 2018

Intramural florid cystic endosalpingiosis of the uterus after menopause.

Pol J Pathol 2018 ;69(3):321-324

Endosalpingiosis is a benign condition characterized by the presence of tubal epithelium outside the fallopian tube and the absence of endometrial stroma. Florid cystic endosalpingiosis is a very rare form of endosalpingiosis that presents as a tumor-like lesion. We report the case of a 67-year-old woman who presented with a cystic lesion of the uterus. Read More

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January 2018

Fatal ruptured ectopic pregnancy - a case report.

Med Leg J 2018 Nov 29:25817218795337. Epub 2018 Nov 29.

Department of Forensic Medicine, M.S. Ramaiah Medical College, Bangalore, India.

A 26-year-old unmarried female with a history of acute abdominal pain and bleeding per vagina was brought unresponsive to the hospital. She was in shock on arrival and could not be resuscitated. Death was registered as a medico-legal case. Read More

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November 2018
1 Read

Back to the Future? The Fallopian Tube, Precursor Escape and a Dualistic Model of High-Grade Serous Carcinogenesis.

Cancers (Basel) 2018 Nov 28;10(12). Epub 2018 Nov 28.

Department of Pathology, Division of Women's and Perinatal Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.

Beginning with the discovery of the -associated ovarian cancer susceptibility genes and subsequent detailed examination of risk-reducing salpingo-oophorectomy (RRSO) specimens, a new paradigm of ovarian carcinogenesis has unfolded with attention to the distal fallopian tube. The primary focus has been an early cancer or neoplasm in the fallopian tube which is seen in virtually all incidentally discovered high-grade serous cancers in asymptomatic women. This high-frequency of tubal involvement in early serous neoplasm (usually in the form of serous tubal intraepithelial carcinoma-STIC) has galvanized attention to this organ as a primary source of this disease. Read More

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November 2018

Methotrexate Therapy for Ectopic Pregnancies: A Tertiary Center Experience.

Rev Bras Ginecol Obstet 2018 Nov 28;40(11):680-685. Epub 2018 Nov 28.

Division of Perinatology, Department of Obstetrics and Gynecology, Faculty of Medicine at Hacettepe University, Ankara, Turkey.

Objective:  Our aim is to demonstrate the importance of methotrexate (MTX) therapy for the treatment of ectopic pregnancy (EP).

Methods:  This retrospective study consisted of 99 patients (72 tubal EPs, 20 pregnancies of unknown location (PUL), 4 cesarean section (CS) scar EPs and 3 cervical EPs) treated with MTX.

Results:  Methotrexate therapy was successful in 68. Read More

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November 2018
1 Read

Endoscopic Evaluation of the Eustachian Tube: assessment of a novel tool for grading Eustachian tube inflammation.

Int Forum Allergy Rhinol 2018 Nov 28. Epub 2018 Nov 28.

Department of Otorhinolaryngology, Mayo Clinic, Phoenix, AZ.

Background: Signs of inflammation are commonly encountered during endoscopic examination of the Eustachian tube (ET) region. The clinical applicability of these findings may be enhanced by use of a standardized assessment score.

Methods: Digital video recordings were obtained of 50 nasal endoscopy examinations of the nasopharyngeal portion of the ET. Read More

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November 2018

Changes in the incidence and uptake of reproductive surgery versus in vitro fertilisation in Australia between 2001 and 2015: A population-based study.

Aust N Z J Obstet Gynaecol 2018 Nov 28. Epub 2018 Nov 28.

School of Mathematics and Applied Statistics, The University of Wollongong, Wollongong, New South Wales, Australia.

Objective: Improvements in success rates of assisted reproduction led to predictions that infertility surgery in both women and men would become extinct in developed countries. We sought to identify the changes in reproductive surgery that occurred between 2001 and 2015 to determine whether these predictions have been accurate.

Design: The Australian Institute of Health and Welfare (AIHW) national procedural dataset and the Australian Medicare Benefits Scheme (MBS) claims database were searched for procedure data for male and female reproductive surgery and assisted reproduction from January 2001 to December 2015. Read More

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November 2018

The cost-effectiveness of opportunistic salpingectomy versus standard tubal ligation at the time of cesarean delivery for ovarian cancer risk reduction.

Gynecol Oncol 2018 Nov 23. Epub 2018 Nov 23.

University of Alabama at Birmingham, Division of Gynecologic Oncology, Birmingham, AL, United States of America.

Objectives: Opportunistic salpingectomy is a cost-effective strategy recommended for ovarian cancer (OvCa) risk reduction at the time of gynecologic surgery in women who have completed childbearing. We aimed to evaluate the cost-effectiveness of opportunistic salpingectomy compared to standard tubal ligation (TL) during cesarean delivery.

Study Design: A cost-effectiveness analysis using decision modeling to compare opportunistic salpingectomy to TL at the time of cesarean using probabilities of procedure completion derived from a trial. Read More

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November 2018
1 Read

No. 366-Gynaecologic Management of Hereditary Breast and Ovarian Cancer.

J Obstet Gynaecol Can 2018 Nov;40(11):1497-1510

Toronto, ON.

Objective: This Committee Opinion outlines the gynaecologic management recommendations for women diagnosed with hereditary breast and ovarian cancer syndrome (HBOC) with respect to screening, contraception, chemoprophylaxis, fertility considerations, risk-reducing surgery, and post-oophorectomy care.

Intended Users: This Committee Opinion is designed for gynaecologic oncologists, general gynaecologists, family physicians, genetic counsellors, registered nurses, nurse practitioners, residents, and health care providers.

Target Population: Adult women (18 years and older) with a pathogenic germline variant in the BRCA1, BRCA2, and other ovarian cancer-associated genes. Read More

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November 2018
3 Reads

A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol.

Trials 2018 Nov 20;19(1):643. Epub 2018 Nov 20.

MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, 47 Little France Crescent, Edinburgh, EH16 4SA, UK.

Background: Tubal ectopic pregnancy (tEP) is the most common life-threatening condition in gynaecology. Treatment options include surgery and medical management. Stable women with tEPs with pre-treatment serum human chorionic gonadotrophin (hCG) levels < 1000 IU/L respond well to outpatient medical treatment with intramuscular methotrexate. Read More

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November 2018
7 Reads

A full term abdominal pregnancy with an isthmic tubal implantation of the placenta.

BMC Pregnancy Childbirth 2018 Nov 19;18(1):448. Epub 2018 Nov 19.

Yalgado Ouédraogo University Teaching Hospital of Ouagadougou, 03 BP 7022, Ouagadougou, 03, Burkina Faso.

Background: Abdominal pregnancy is defined as the partial or total insertion of the embryo into the abdominal cavity. It is rare, and can evolve towards the full term if it is not recognized in the early pregnancy. It carries a high risk of maternal-fetal morbidity and mortality. Read More

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November 2018
1 Read

[Management and pregnancy outcomes of heterotopic pregnancy].

Zhonghua Fu Chan Ke Za Zhi 2018 Nov;53(11):768-775

Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.

To investigate the clinical features, diagnosis and treatments of heterotopic pregnancy (HP) and demonstrate the outcomes of HP after the surgical treatment of ectopic pregnancies. A retrospective analysis was performed on 144 cases of HP in Womens Hospital, School of Medicine, Zhejiang University from January 2003 to December 2016. (1) Clinical features of HP:the average age of patients was (30. Read More

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November 2018
2 Reads

Does presence of adenomyosis affect reproductive outcome in IVF cycles? A retrospective analysis of 973 patients.

Reprod Biomed Online 2018 Oct 26. Epub 2018 Oct 26.

Institute of Reproductive Medicine, HB-36/A/3, Salt Lake City, Sector-III, Kolkata, Kolkata 700106, India.

Research Question: Reports on the effect of adenomyosis on assisted reproductive technology (ART) outcomes are conflicting. Does presence of adenomyosis affect reproductive outcome in IVF cycles in women pretreated with gonadotrophin releasing hormone (GnRH) agonist?

Design: In this retrospective cohort study, 973 women were divided into four groups: only endometriosis (n = 355); endometriosis and adenomyosis (n = 88); adenomyosis alone (n = 64); and tubal factor infertility as controls (n = 466). The pregnancy outcome parameters (clinical pregnancy, miscarriage rate, live birth rate) were compared between these groups. Read More

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October 2018
3 Reads
3.020 Impact Factor

Networks of E-cadherin, β1 integrin, and focal adhesion kinase in the pathogenesis of tubal pregnancy.

Gynecol Endocrinol 2018 Nov 15:1-5. Epub 2018 Nov 15.

b Institute of Reproductive Immunology, College of Life Science and Technology , Jinan University , Guangzhou , People's Republic of China.

E-cadherin, β1 integrin, and focal adhesion kinase (FAK) are reported to involved in eutopic implantation by mediating cell adhesion. However, less is documented about their roles in ectopic implantation. This study was undertaken to evaluate the roles and networks of E-cadherin, β1 integrin, and FAK in tubal pregnancy. Read More

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November 2018
2 Reads

Chronic tubal ectopic pregnancy following clinically successful methotrexate treatment for an acute ectopic: a review of the literature.

J Obstet Gynaecol 2018 Nov 14:1-2. Epub 2018 Nov 14.

b Department of Obstetrics and Gynaecology , Danat El Emarat Hospital , Abu Dhabi , UAE.

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November 2018
1 Read

Impact of Laparoscopy to Assess Resectability in Stage IIIC Epithelial Ovarian, Tubal and Peritoneal Cancer Patients.

Gynecol Obstet Invest 2018 Nov 14:1-9. Epub 2018 Nov 14.

Unit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Aims: To evaluate overall survival (OS) and progression-free survival (PFS) in patients with stage IIIC epithelial ovarian, tubal and peritoneal cancer (EOC) who underwent a laparoscopy to assess surgical resectability prior to Primary Debulking Surgery (PDS) or Interval Debulking Surgery (IDS).

Methods: Retrospective cohort study that included all women with stage IIIC EOC treated at our center between 2000 and 2010. Patients were classified in groups: PDS, neoadjuvant chemotherapy (NACT) with IDS, NACT without IDS; and then sub-classified based on residual tumor (RT). Read More

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November 2018
4 Reads

A Pilot Study Comparing 2- and 3-Dimensional Ultrasound Imaging for Confirmation of ESSURE® Fallopian Tube Pregnancy Prevention Implants.

J Minim Invasive Gynecol 2018 Nov 11. Epub 2018 Nov 11.

Service de Gynécologie Obstétrique, CHU Nantes. Electronic address:

Study Objective: To demonstrate the feasibility of 2-dimensional ultrasound (2DUS) imaging compared to 3-dimensionnal ultrasound (3DUS) to identify the location of implants and assess if the classification developed by Simorre et al described in 2016 was applicable to the 2 types of ultrasound imaging (2D and 3D).

Design: A prospective study (Canadian Task Force classification II-2).

Setting: Department of obstetrics and gynecology in a teaching hospital. Read More

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November 2018
5 Reads

Cell Origins of High-Grade Serous Ovarian Cancer.

Cancers (Basel) 2018 Nov 12;10(11). Epub 2018 Nov 12.

Department of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

High-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), is the most common and deadliest type of ovarian cancer. HGSC appears to arise from the ovary, fallopian tube, or peritoneum. As most HGSC cases present with widespread peritoneal metastases, it is often not clear where HGSC truly originates. Read More

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November 2018
2 Reads

Tubal sterilization during cesarean section at a training hospital in Turkey: A clinical and demographic analysis.

Authors:
S Arlier

Niger J Clin Pract 2018 Nov;21(11):1508-1513

Department of Obstetrics and Gynecology, Adana Numune Training and Research Hospital, Adana, Turkey.

Background: The total fertility rate is 2.1 children per women in Turkey. The population is expected to increase to 84 million by 2023. Read More

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November 2018
1 Read

Design, Manufacture, and Testing of a Tissue Scaffold for Permanent Female Sterilization by Tubal Occlusion.

MRS Adv 2018 15;3(30):1685-1690. Epub 2018 Jan 15.

Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, U.S.A.

Current FDA-approved permanent female sterilization procedures are invasive and/or require the implantation of non-biodegradable materials. These techniques pose risks and complications, such as device migration, fracture, and tubal perforation. We propose a safe, non-invasive biodegradable tissue scaffold to effectively occlude the Fallopian tubes within 30 days of implantation. Read More

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January 2018
1 Read

Ectopic Pregnancy: Risk Factors, Clinical Presentation and Management.

J Obstet Gynaecol India 2018 Dec 18;68(6):487-492. Epub 2017 Nov 18.

Department of Obstetrics and Gynaecology, Sri Ramachandra Medical College and Research Institute, Chennai, 600097 India.

Background: Ectopic pregnancy is increasing in incidence. Nevertheless, there is wide availability of tools for early diagnosis and advances in management. Though it is not a leading cause of maternal mortality, it significantly causes morbidity and jeopardizes reproductive outcome in women desirous of fertility. Read More

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December 2018
6 Reads

Hemoperitoneum in a Peritoneal Dialysis Patient: Ruptured Ectopic Pregnancy.

Perit Dial Int 2018 Nov-Dec;38(6):455-456

Surgery, University of Chicago Medical Center, Chicago, IL, USA.

Hemoperitoneum is a well-recognized complication in female peritoneal dialysis (PD) patients of childbearing age. Bloody effluent is commonly of minor nature, presenting during menstruation or midcycle, resolving after a few rapid exchanges without a need for further intervention. One must remain vigilant, however, and consider a broader differential diagnosis when hemoperitoneum is persistent or severe, as it indicates a serious and potentially life-threatening etiology. Read More

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November 2018
3 Reads

Interstitial Pregnancy: From Medical to Surgical Approach-Report of Three Cases.

Case Rep Obstet Gynecol 2018 15;2018:2815871. Epub 2018 Oct 15.

Department of Obstetrics and Gynecology, SS Annunziata Hospital, Chieti, Italy.

Background: Interstitial pregnancy is a rare form of ectopic pregnancy that usually leads to uterine rupture resulting in sudden life-threatening haemorrhage, need for blood transfusion, and admission to intensive care unit. Mortality rate is 6-7 times higher than that in classical ectopic pregnancy. Uterine rupture has been typically reported to occur at more advanced gestational ages compared to tubal pregnancy although several recent reports have shown a high risk of rupture before 12 weeks of gestation. Read More

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October 2018
11 Reads

Impact of the Time Interval from Neoadjuvant Chemotherapy to Surgery in Primary Ovarian, Tubal, and Peritoneal Cancer Patients.

J Cancer 2018 18;9(21):4087-4091. Epub 2018 Oct 18.

Department of Obstetrics and Gynecology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Neoadjuvant chemotherapy (NACT) plays an important role in ovarian cancer. The appropriate time interval from the completion of NACT to interval debulking surgery (TTS) in ovarian cancer is still unknown. The aim of this retrospective study was to evaluate the effect of the time interval between the end of NACT and surgery (TTS ≤ 4 weeks vs TTS > 4 weeks) on the survival outcomes among patients with advanced-stage ovarian, tubal, and peritoneal cancers. Read More

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October 2018
6 Reads

[Sexually transmitted infections and male fertility].

Hautarzt 2018 Dec;69(12):1006-1013

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

Background: Sexually transmitted infections (STI) are common worldwide and can cause impairment of fertility. In women pelvic inflammatory disease with subsequent tubal sterility is well-documented but the influence of STI on male fertility is still controversely discussed OBJECTIVE: The effects of various bacterial and viral STI on male fertility are discussed.

Material And Methods: An evaluation of the international literature up to 30 April 2018 was carried out including studies on larger collectives from the Asiatic region. Read More

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December 2018
3 Reads

Is IUI with ovarian stimulation effective in couples with unexplained subfertility?

Hum Reprod 2018 Nov 5. Epub 2018 Nov 5.

Department of Biostatistics and Research Support, Julius Centre, University Medical Centre Utrecht, Heidelberglaan 100, CX Utrecht, the Netherlands.

Study Question: Does starting IUI with ovarian stimulation (IUI-OS) within 1.5 years after completion of the fertility workup increase ongoing pregnancy rates compared to expectant management in couples with unexplained subfertility?

Summary Answer: IUI-OS is associated with higher chances of ongoing pregnancy compared to expectant management in unexplained subfertile couples, specifically those with poor prognoses of natural conception, i.e. Read More

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November 2018
3 Reads

Management of unilateral tubal block at hysterosalpingogram.

Authors:
H Burks

BJOG 2018 Nov 5. Epub 2018 Nov 5.

Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.

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November 2018

Common Methylenetetrahydrofolate Reductase Polymorphisms (A1298C & C677T) in Ectopic Trophoblasts and Methotrexate Treatment Failure in Tubal Pregnancies.

Ginekol Pol 2018 ;89(10):536-540

Department of Obstetrics and Gynecology, Adnan Menderes University Hospital, Aytepe, 09100 Aydin, Turkey.

Objectives: The success rate of methotrexate (MTX) therapy varies among tubal ectopic pregnancies. Common methylenetetrahydrofolate reductase (MTHFR) polymorphisms (C677T&A1298C) have been suggested to alter MTX effect. This study aimed to assess and compare MTX treatment failure rates with respect to MTHFR polymorphisms in trophoblasts of ectopic tubal pregnancies. Read More

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January 2018
8 Reads

Frontiers in the Pathology and Pathogenesis of Ovarian Cancer: Cancer Precursors and "Precursor Escape".

Hematol Oncol Clin North Am 2018 Dec;32(6):915-928

Department of Pathology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. Electronic address:

This article summarizes the pathogenesis of ovarian carcinoma, focusing on the paradox of high-grade serous carcinogenesis. The fallopian tube is the prime site of origin in early serous cancers. Because a subset of serous cancers is associated with early serous proliferations absent intramucosal carcinomas, "precursor escape" is emerging, whereby some advanced cancers trace their roots to early serous proliferations. Read More

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December 2018
1 Read

Uterine and Tubal Lavage for Earlier Cancer Detection Using an Innovative Catheter: A Feasibility and Safety Study.

Int J Gynecol Cancer 2018 Nov;28(9):1692-1698

Molecular Oncology Group, Department of Obstetrics and Gynecology, Comprehensive Cancer Center-Gynecologic Cancer Unit, Medical University of Vienna, Vienna, Austria.

Objectives: Poor survival of high-grade serous pelvic cancer is caused by a lack of effective screening measures. The detection of exfoliated cells from high-grade serous pelvic cancer, or precursor lesions, is a promising concept for earlier diagnosis. However, collecting those cells in the most efficient way while fulfilling all requirements for a screening approach is a challenge. Read More

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November 2018
1 Read

Detection of tumor cells of serous tubal intraepithelial carcinoma (STIC) in cervical smears and rapid development of the ovarian involvement: A case report.

Diagn Cytopathol 2018 Nov 30;46(11):945-949. Epub 2018 Oct 30.

Department of Gynecology, Shiga General Hospital, Moriyama, Shiga, Japan.

Serous tubal intraepithelial carcinoma (STIC) has attracted attention as a precursor lesion of high-grade serous carcinoma (HGSC) of the ovary. We report the rare case of a woman in whom adenocarcinoma cells were detected in cervical smears and demonstrated to be derived from STIC in the fimbria. The patient was a 48-year-old woman, in whom cervical smears contained adenocarcinoma cells, but cervical conization did not reveal adenocarcinoma. Read More

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November 2018
1 Read

Down-regulation of long non-coding RNA MALAT1 inhibits granulosa cell proliferation in endometriosis by up-regulating P21 via activation of the ERK/MAPK pathway.

Mol Hum Reprod 2018 Oct 27. Epub 2018 Oct 27.

Center for Reproductive Medicine, Department of Gynecology and Obstetrics, Nanfang Hospital, Southern Medical University, Guangzhou, People's Republic of China.

Study Question: Is there a specific mechanism underlying the association between lung adenocarcinoma transcript 1 (MALAT1) and endometriosis-related infertility?

Summary Answer: The down-regulation of MALAT1 in endometriosis granulosa cells (GCs) may have an adverse effect on the growth and development of oocytes by inhibiting GC proliferation, due to cell cycle-dependent mechanisms that enhance P21 expression through activation of the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway.

What Is Known Already: The association between endometriosis and infertility is well supported throughout the literature, and endometriosis per se and its surgical treatment have an adverse effect on the ovarian reserve and on oocyte development. MALAT1, one of the most extensively expressed and evolutionarily conserved transcripts, has been implicated to play a role in human development and many diseases. Read More

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October 2018
5 Reads

Isolated Tubal Torsion after Tubal Ligation.

J Minim Invasive Gynecol 2018 Oct 24. Epub 2018 Oct 24.

Department of Obstetrics and Gynecology, Penn State Health Hershey Medical Center, Hershey, Pennsylvania.

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October 2018

Appendiceal endosalpingiosis: clinical presentation and imaging appearance of a rare condition of the appendix.

Abdom Radiol (NY) 2018 Oct 26. Epub 2018 Oct 26.

Department of Pathology, Henry Ford Hospital, 2799 West Grand Blvd, Detroit, MI, 48202, USA.

Endosalpingiosis rarely affects the appendix but can be mistaken for acute appendicitis or appendiceal tumors. The medical literature regarding appendiceal endosalpingiosis is sparse; consisting of only four case reports which are primarily focused on the histopathology but provide little radiologic correlation. Endosalpingiosis is a rare condition characterized by the presence of benign fallopian tubal-like glandular epithelium derived from Mullerian ducts, usually affecting the serosal surfaces of the pelvis and peritoneum. Read More

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October 2018
16 Reads

Ovarian Reserve and Assisted Reproductive Technique Outcomes After Laparoscopic Proximal Tubal Occlusion or Salpingectomy in Women with Hydrosalpinx Undergoing in Vitro Fertilization: A Randomized Controlled Trial.

J Minim Invasive Gynecol 2018 Oct 24. Epub 2018 Oct 24.

ART Center, Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.

Study Objective: To evaluate the outcomes of assisted reproductive technology (ART) after proximal tubal occlusion (PTO) or salpingectomy in patients with hydrosalpinx undergoing in vitro fertilization-embryo transfer (IVF-ET).

Design: Randomized controlled trial (Canadian Task Force classification I).

Setting: All India Institute of Medical Sciences, New Delhi, India. Read More

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October 2018
5 Reads

Yak (Bos grunniens) Tonsils: Morphological Description and Expression of IgA and IgG.

Anat Rec (Hoboken) 2018 Oct 26. Epub 2018 Oct 26.

Gansu Province Livestock Embryo Engineering Research Center, Department of Clinical Veterinary Medicine, Faculty of Veterinary Medicine, Gansu Agricultural University, Lanzhou, Gansu, China.

This study aimed to describe the morphology, expression of IgA and IgG in adult yak tonsils. The 12 clinically healthy yak tonsils [3- to 6-year old, n = 12] were examined for morphology using light, and transmission electron microscopes. Expression of IgA and IgG was measured by qRT-PCR, ELISA, and immunohistochemistry. Read More

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October 2018

Post-partum tubal ligation at time of cesarean delivery or via laparoscopy as an interval sterilization has similar effects on ovarian reserve

J Turk Ger Gynecol Assoc 2018 Oct 26. Epub 2018 Oct 26.

Ankara University School of Medicine Obstetrics and Gynecology Department Ankara, Turkey

Objective: To observe and compare the effect of postpartum tubal ligation procedures on ovarian reserve at women desiring tubal ligation as a contraceptive method at the end of pregnancy.

Material And Methods: Eighty-one women were included in the prospective study. Tubal ligation (TL) was performed at time of cesarean delivery (CD) (n:49) and as an interval procedure by laparoscopy (LS) at postpartum period (n:32). Read More

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October 2018
1 Read

External validation of a dynamic prediction model for repeated predictions of natural conception over time.

Hum Reprod 2018 Dec;33(12):2268-2275

Medical Statistics, Department of Biomedical Sciences, Leiden University Medical Centre, Einthovenweg 20, Leiden, the Netherlands.

Study Question: How well does a previously developed dynamic prediction model perform in an external, geographical validation in terms of predicting the chances of natural conception at various points in time?

Summary Answer: The dynamic prediction model performs well in an external validation on a Scottish cohort.

What Is Known Already: Prediction models provide information that can aid evidence-based management of unexplained subfertile couples. We developed a dynamic prediction model for natural conception (van Eekelen model) that is able to update predictions of natural conception when couples return to their clinician after a period of unsuccessful expectant management. Read More

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December 2018
13 Reads

Unilateral twin tubal pregnancy: a case report and review of the literature.

Acta Biomed 2018 Oct 8;89(3):423-427. Epub 2018 Oct 8.

Department of Obstetrics and Gynaecology, ASTT Lecco, Ospedale Alessandro Manzoni, Lecco, Italy.

Background: Unilateral twin tubal pregnancy is an extremely rare condition, occurring in 1/20.000-250.000 pregnancies and represents a major health risk for reproductive-aged women, leading to even life-threatening complications. Read More

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October 2018
2 Reads

Management of contraceptives and menstrual complaints in patients with Down syndrome.

Gynecol Endocrinol 2018 Oct 16:1-6. Epub 2018 Oct 16.

a Post Graduate Program in Gynecology and Obstetrics, Universidade Federal do Paraná , Curitiba , Brazil.

Enhanced health care for patients with Down syndrome (DS) results in improved overall quality of life and longer life expectancy. The main gynecologic complaints of patients with DS and their caregivers relate to menstrual cycles, hygiene and reproductive issues. Certain aspects, such as age of menarche, menstrual cycles, internal genitalia, and hormone profile are similar to those observed in the general population. Read More

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October 2018
4 Reads

Risk factors and human chorionic gonadotropin trends in patients with ruptured tubal ectopic pregnancies despite methotrexate treatment.

Gynecol Endocrinol 2018 Oct 15:1-4. Epub 2018 Oct 15.

b The Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine, Weill Cornell Medicine , New York , NY , USA.

This retrospective cohort study investigates the risk factors and beta-human chorionic gonadotropin (β-hCG) trends in patients with ruptured tubal ectopic pregnancies (EPs) despite methotrexate (MTX) treatment. All patients receiving MTX for sonographically confirmed tubal EPs at our fertility center between 2004 and 2014 were included. Baseline demographics and β-hCG trends of patients with EP rupture after MTX were compared to patients with resolved EPs after MTX. Read More

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October 2018
4 Reads