489 results match your criteria Truncus Arteriosus Imaging

The Arginine Methyltransferase Carm1 is Necessary for Heart Development.

G3 (Bethesda) 2022 Jun 23. Epub 2022 Jun 23.

Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, Seattle WA 98101 USA.

To discover genes implicated in human congenital disorders, we performed ENU mutagenesis in the mouse and screened for mutations affecting embryonic development. In this work we report defects of heart development in mice homozygous for a mutation of Coactivator-associated Arginine Methyltransferase 1 (Carm1). While Carm1 has been extensively studied, it has never been previously associated with a role in heart development. Read More

View Article and Full-Text PDF

The Secrets of the Frogs Heart.

Pediatr Cardiol 2022 Mar 15. Epub 2022 Mar 15.

Children's Heart Institute, Memorial Hermann Children's Hospital, McGovern Medical School, University of Texas Health, 6431 Fannin Street, MSB 6.274, Houston, TX, 77030, USA.

The heart of the African clawed frog has a double-inlet and single-outlet ventricle supporting systemic and pulmonary circulations via a truncus, and a lifespan of 25-30 years. We sought to understand the unique cardiac anatomic and physiologic characteristics, with balanced circulation and low metabolic rate, by comparing the basic anatomy structures with focused echocardiography and cardiac magnetic resonance imaging. Twenty-four adult female African clawed frogs were randomly subjected to anatomic dissection (n = 4), echocardiography (n = 10), and cardiac magnetic resonance (n = 10). Read More

View Article and Full-Text PDF

Accuracy of Fetal Echocardiography in Defining Anatomic Details: A Single-Institution Experience over a 12-Year Period.

J Am Soc Echocardiogr 2022 Mar 12. Epub 2022 Mar 12.

Fetal & Neonatal Cardiology Program, Division of Cardiology, Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada; Department of Obstetrics & Gynecology, Women's & Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada. Electronic address:

Background: Fetal echocardiography has evolved over four decades, now permitting the prenatal diagnoses of most major congenital heart disease (CHD). To identify areas for targeted improvement, the authors explored the diagnostic accuracy of fetal echocardiography in defining major fetal CHD.

Methods: All fetuses with major fetal CHD (11 subtypes) at a single institution between 2007 and 2018 were identified (n = 827). Read More

View Article and Full-Text PDF

VACTERL association in a fetus with multiple congenital malformations - Case report.

J Med Life 2021 Nov-Dec;14(6):862-867

Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest, Romania.

VACTERL represents an acronym for a broad spectrum of congenital anomalies such as vertebral anomalies, anorectal anomalies (anal atresia), cardiac anomalies, tracheoesophageal fistula or atresia, renal anomalies, and limb anomalies. We present the case of a male fetus with multiple anomalies consistent with VACTERL association such as scoliosis, imperforate anus, common truncus arteriosus, tracheoesophageal fistula associated with inferior esophagus atresia, polycystic kidneys, with short right ureter, lower limb hypoplasia micrognathia, hygroma, duodenal atresia, and cloacal malformation, with an aberrant omphalomesenteric duct. The presented case highlights the crucial importance of pathologists specialized in the dissection and confirmation of fetal abnormalities as an essential part of the multidisciplinary team that establishes the management of complicated pregnancies with this type of pathology. Read More

View Article and Full-Text PDF
February 2022

[Prenatal diagnosis and clinical outcomes of 297 fetuses with conotruncal defects].

Zhonghua Fu Chan Ke Za Zhi 2022 Jan;57(1):25-31

Prenatal Diagnostic Center, Guangzhou Women and Children's Medical Center, Guangzhou 510623, China.

To analyze the prenatal diagnosis results and pregnancy outcomes of conotruncal defects (CTD) fetuses, and to explore the correlation between the CTD and chromosome diseases. A total of 297 cases of invasive prenatal diagnosis and chromosome analysis were collected at the Prenatal Diagnosis Center of Guangzhou Women and Children's Medical Center due to CTD from January 1st, 2011 to December 31th, 2019. According to ultrasonic diagnosis, CTD fetuses were divided into 6 subtypes: tetralogy of Fallot (109 cases), pulmonary atresia (30 cases), transposition of the great arteries (77 cases), double outlet right ventricle (53 cases), truncus arteriosus (14 cases) and interrupted aortic arch (14 cases). Read More

View Article and Full-Text PDF
January 2022

Common Arterial Trunk with Interrupted Aortic Arch.

Braz J Cardiovasc Surg 2022 03 10;37(1):131-134. Epub 2022 Mar 10.

Department of Pediatrics and Pediatric Surgery, Pediatric Cardiology and Cardiovascular Surgery Service at Hospital da Criança e Maternidade de São José do Rio Preto, São Paulo, Brazil.

Clinical Data: Patient diagnosed with common arterial trunk, submitted to pulmonary artery banding in another center and lost to clinical follow-up. Referred to our center at four years old, extremely cyanotic. Chest radiography: Cardiomegaly; attenuated peripheral vascular markings. Read More

View Article and Full-Text PDF

Common arterial trunk with crossed pulmonary arteries.

J Card Surg 2022 Mar 7;37(3):675-677. Epub 2022 Jan 7.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

We report a case of a 27-day-old girl with an unusual association of crossed pulmonary arteries with common arterial trunk showing pulmonary dominance with an interruption of aortic arch between the origin of the left common carotid artery and left subclavian artery. This case highlights the potential airway-related implications of this variant pulmonary arterial anatomy in the setting of the common arterial trunk and the role of computed tomography angiography in providing not only accurate and three-dimensional visualization of complex cardiovascular anatomy, but also a comprehensive evaluation of associated airway abnormalities with great precision. Read More

View Article and Full-Text PDF

Pulmonary Versus Systemic Outflow Obstruction in Functionally Univentricular Hearts with Isomerism: An Observation.

Pediatr Cardiol 2022 Jun 3;43(5):995-998. Epub 2022 Jan 3.

Congenital Heart Center Nevada, 3006 S. Maryland Pkwy Ste. 690, Las Vegas, NV, 89109, USA.

Our objective was to review our experience with isomerism associated with univentricular hearts and evaluate the prevalence of pulmonary versus systemic outflow obstruction. We identified those prenatally or postnatally diagnosed, between September 2004 and October 2021, with right and left isomerism and a functionally univentricular heart. We identified 62, 51 prenatally and 11 postnatally. Read More

View Article and Full-Text PDF

Management of Interrupted Aortic Arch With Associated Anomalies: A Single-Center Experience.

World J Pediatr Congenit Heart Surg 2021 11;12(6):706-714

Atakent Hospital, 162328Acibadem Mehmet Ali Aydinlar University, İstanbul, Turkey.

Objectives: Interrupted aortic arch (IAA) includes a broad spectrum of associated anomalies. In this study, we present our surgical management and patient-specific decisions regarding IAA anomalies with early- and mid-term outcomes.

Methods: The medical records of 25 patients undergoing IAA repair between 2014 and 2019 were retrospectively reviewed. Read More

View Article and Full-Text PDF
November 2021

Large aortopulmonary collateral artery exclusively supplying the lower lobe of left lung in an infant with common arterial trunk with aortic dominance with confluent pulmonary arteries.

J Card Surg 2022 Feb 2;37(2):433-436. Epub 2021 Nov 2.

Department of Cardiothoracic Surgery, National Heart Center, Royal Hospital, Muscat, Oman.

Introduction: Common arterial trunk with aortic dominance has well-developed bilateral pulmonary arterial arborization without any essential major aortopulmonary collateral arteries (MAPCAs), whereas "solitary" arterial trunk is characterized by collateral arterial supply to all bronchopulmonary segments and absent pulmonary arteries.

Case Report: We report a term female neonate with common arterial trunk with aortic dominance with confluent pulmonary arteries with a large MAPCA as the sole blood supply to the lower lobe of the left lung.

Results: Initial diagnostic workup missed this MAPCA from the descending thoracic aorta. Read More

View Article and Full-Text PDF
February 2022

Lessons Learned from Infants with Late Detection of Critical Congenital Heart Disease.

Pediatr Cardiol 2022 Mar 28;43(3):580-585. Epub 2021 Oct 28.

Division of Cardiology and The Children's National Heart Institute, Children's National Hospital, 111 Michigan Avenue, N.W., Washington, D.C., 20010, USA.

Late detection of critical congenital heart disease (CCHD) is multifactorial and ill defined. We investigated the results of pulse oximetry screening (POS) and points in the care chain that contribute to delayed detection of CCHD. The medical records of 13 infants with delayed detection at a single pediatric cardiac center between 2013 and 2016 were identified and reviewed. Read More

View Article and Full-Text PDF

Anterior Translocation of the Right Pulmonary Artery to Relieve Bronchial Compression in Truncus Arteriosus With Interrupted Aortic Arch.

World J Pediatr Congenit Heart Surg 2022 Jan 14;13(1):111-113. Epub 2021 Sep 14.

Labatt Family Heart Centre, 7979The Hospital for Sick Children, Toronto, Canada.

We report an anterior translocation of the right pulmonary artery procedure to relieve severe left bronchial obstruction that was caused by right pulmonary artery stent placement in a 1-year-old patient with truncus arteriosus and interrupted aortic arch. After neonatal repair, the patient re-presented with severe truncal valve regurgitation, right pulmonary artery stenosis, and severe biventricular dysfunction, which was treated with truncal valve repair and right pulmonary artery plasty. The patient suffered from left bronchial compression from right pulmonary artery stent placement, which was successfully treated by the translocation procedure. Read More

View Article and Full-Text PDF
January 2022

Truncus arteriosus as presentation of PHACE syndrome.

BMJ Case Rep 2021 Sep 13;14(9). Epub 2021 Sep 13.

Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

PHACE syndrome is a rare neurocutaneous syndrome that describes the association of large segmental infantile haemangioma involving the head and neck, along with other systemic anomalies. Complex congenital heart disease has rarely been reported in this syndrome. We present a report of a patient with PHACE syndrome and truncus arteriosus. Read More

View Article and Full-Text PDF
September 2021

Truncus arteriosus with absent semilunar valve: Prenatal diagnosis and morphology.

Lihong Pu Jiao Chen

Prenat Diagn 2021 Dec 9;41(13):1718-1719. Epub 2021 Sep 9.

Department of Ultrasonic Medicine, West China Second University Hospital of Sichuan University, Chengdu, China.

View Article and Full-Text PDF
December 2021

Anuran development: A reinvestigation of the conus arteriosus and gill formation in Bufo bufo throughout metamorphosis using micro-CT.

Anat Rec (Hoboken) 2022 05 27;305(5):1100-1111. Epub 2021 Sep 27.

Department of Evolutionary Biology Theoretical Biology Unit, University of Vienna, Vienna, Austria.

Using high-resolution X-ray micro-CT imaging of whole Bufo bufo specimens, we acquired detailed 3D descriptions of the changing morphology of the cardiac outflow structures, in particular the conus arteriosus through larval development and the transition. Previous findings regarding anuran conal structures were contradictory, depending on the specifics of the 2D imaging methods used by different authors. Our descriptions of conal morphology at different developmental stages show that early tadpoles initially only have one opening at the ventricular-conal junction and only one cavum within their conus; however, the forming septum coni soon divides the conus into two chambers, the cavum pulmocutaneum and the cavum aorticum. Read More

View Article and Full-Text PDF

Common arterial trunk in the era of high prenatal detection rates: Results of neonatal palliation and primary repair.

J Card Surg 2021 Nov 30;36(11):4090-4094. Epub 2021 Aug 30.

Congenital Heart Center Nevada, Las Vegas, Nevada, USA.

Objective: We reviewed our center's experience with common arterial trunk.

Methods: We included those with common arterial trunk in Nevada with estimated delivery dates or birth dates between June 2006 and May 2021. We excluded patients with functionally univentricular hearts. Read More

View Article and Full-Text PDF
November 2021

A staged approach for truncus arteriosus: proceed with caution.

Eur J Cardiothorac Surg 2022 03;61(4):795-796

Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, ON, Canada.

View Article and Full-Text PDF

Prognostic Value of CTA-Derived Left Ventricular Mass in Neonates with Congenital Heart Disease.

Diagnostics (Basel) 2021 Jul 6;11(7). Epub 2021 Jul 6.

Department of Radiology, University Hospital Erlangen, Maximiliansplatz 3, 91054 Erlangen, Germany.

For therapeutic decisions regarding uni- or biventricular surgical repair in congenital heart disease (CHD), left ventricular mass (LVM) is an important factor. The aim of this retrospective study was to determine the LVM of infants with CHD in thoracic computed tomography angiographies (CTAs) and to evaluate its usefulness as a prognostic parameter, with special attention paid to hypoplastic left heart (HLH) patients. Manual segmentation of the left ventricular endo- and epicardial volumes was performed in CTAs of 132 infants. Read More

View Article and Full-Text PDF

Novel concepts and early results of repairing common arterial trunk.

Eur J Cardiothorac Surg 2022 Feb;61(3):562-571

Radiology Department, Aswan Heart Centre, Aswan, Egypt.

Objectives: Common Arterial Trunk (CAT) continues to have a very poor prognosis globally. To address that, we have developed a novel technique targeting key concepts for the correction of all components of the anomaly, using autologous arterial tissue. This aims to enhance results, availability worldwide, and importantly to avoid the need for repeated reoperations. Read More

View Article and Full-Text PDF
February 2022

Bcar1/p130Cas is essential for ventricular development and neural crest cell remodelling of the cardiac outflow tract.

Cardiovasc Res 2022 Jun;118(8):1993-2005

Centre for Cardiometabolic and Vascular Science, BHF Laboratories, UCL Division of Medicine, 5 University Street, London WC1E 6JF, UK.

Aims: The adapter protein p130Cas, encoded by the Bcar1 gene, is a key regulator of cell movement, adhesion, and cell cycle control in diverse cell types. Bcar1 constitutive knockout mice are embryonic lethal by embryonic days (E) 11.5-12. Read More

View Article and Full-Text PDF

Double trouble: A hitherto undescribed association of tricuspid atresia and common arterial trunk!

J Card Surg 2021 Aug 30;36(8):2941-2943. Epub 2021 May 30.

Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India.

View Article and Full-Text PDF

Three-dimensional images of a pulmonary dominant truncus arteriosus before and after a novel repair.

Glob Cardiol Sci Pract 2021 Apr 30;2021(1):e202109. Epub 2021 Apr 30.

Aswan Heart Centre, Aswan, Egypt.

This paper documents, for the first time, the size, geometry, and function of the different components of this important subtype of truncus arteriosus (pulmonary dominant). Previous descriptions were based on examining formalin-fixed (collapsed) specimens, or descriptions during operations. It is hoped that this information can be of value in designing operative treatment as well as interpreting future sequential imaging, with the aim of optimizing the results of comprehensive repair. Read More

View Article and Full-Text PDF

Prenatal diagnosis, associated findings and postnatal outcome of fetuses with truncus arteriosus communis (TAC).

Arch Gynecol Obstet 2021 12 24;304(6):1455-1466. Epub 2021 May 24.

Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, Kerpenerstr. 34, 50931, Cologne, Germany.

Purpose: To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with truncus arteriosus communis (TAC) METHODS: All cases of TAC diagnosed prenatally over a period of 8 years were retrospectively collected in two tertiary referral centers. All additional prenatal findings were assessed and correlated with the outcome. The accuracy of prenatal diagnosis was assessed. Read More

View Article and Full-Text PDF
December 2021

Commentary: As good as new: Using modulated renewal to analyze reintervention after truncus arteriosus repair.

J Thorac Cardiovasc Surg 2022 01 20;163(1):239-241. Epub 2021 Apr 20.

Division of Congenital Heart Surgery, Texas Children's Hospital, Baylor College of Medicine, Houston, Tex. Electronic address:

View Article and Full-Text PDF
January 2022

Acyanotic Truncus Arteriosus: Not a Misnomer But a True Rarity.

World J Pediatr Congenit Heart Surg 2022 Jan 6;13(1):104-106. Epub 2021 May 6.

Department of Paediatric Cardiac Intensive Care, Sri Sathya Sai Sanjeevani International Centre for Child Heart Care and Research, Palwal, Haryana, India.

Truncus arteriosus, also referred to as common arterial trunk (CAT), is generally classified as a cyanotic congenital heart disease characterized by a single arterial trunk arising from the heart and supplying both pulmonary and systemic circulations. Cyanosis exists by virtue of it being an admixture lesion. We report a 13-year-old boy diagnosed to have type 1 CAT who was acyanotic at presentation and had all features of an operable lesion even at this age. Read More

View Article and Full-Text PDF
January 2022

Common arterial trunk type I in a 15-year-old boy with grade I pulmonary hypertension.

Rev Esp Cardiol (Engl Ed) 2021 09 12;74(9):810-812. Epub 2021 Apr 12.

Departamento de Cirugía Cardiaca Pediátrica y Cardiopatías Congénitas, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de México, Mexico. Electronic address:

View Article and Full-Text PDF
September 2021

Persistent truncus arteriosus with an anomalous coronary artery in a cat.

J Vet Cardiol 2021 Jun 4;35:8-13. Epub 2021 Mar 4.

Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu-shi, Tokyo 183-8538, Japan.

A 6-month-old, female, domestic shorthair cat weighing 1.8 kg presented with cardiomegaly seen on radiographs taken at a primary care veterinary center. Echocardiography revealed a single enlarged vessel overriding a ventricular septal defect and severe hypertrophy of the right ventricular free wall. Read More

View Article and Full-Text PDF

Diagnostic quality of 3Tesla postmortem magnetic resonance imaging in fetuses with and without congenital heart disease.

Am J Obstet Gynecol 2021 08 1;225(2):189.e1-189.e30. Epub 2021 Mar 1.

Department of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.

Background: Postmortem confirmation of prenatally diagnosed congenital heart disease after termination of pregnancy and evaluation of potential cardiac defects after spontaneous fetal or neonatal death are essential. Conventional autopsy rates are decreasing, and 1.5Tesla magnetic resonance imaging has demonstrated limited diagnostic accuracy for postmortem cardiovascular assessment. Read More

View Article and Full-Text PDF

Modified Tran Viet-Neveux technique of truncus arteriosus repair.

Asian Cardiovasc Thorac Ann 2021 Jul 2;29(6):563-564. Epub 2021 Mar 2.

Department of Pediatric Cardiac Surgery, National Heart Institute, Kuala Lumpur, Malaysia.

View Article and Full-Text PDF