45 results match your criteria True Malignant Mixed Tumor Carcinosarcoma


Giant Cell Carcinosarcoma of the Parotid Gland With a PLAG 1 Translocation in Association With a Pleomorphic Adenoma With HMGA2 Translocation.

Am J Clin Pathol 2020 11;154(6):811-815

Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia.

Objectives: Carcinosarcomas of the salivary gland are rare neoplasms and have been described arising de novo or in association with pleomorphic adenoma (PA). PLAG1 and HMGA2 translocations are known to occur in PAs and carcinomas ex PA but are mutually exclusive.

Methods: We report a case of a carcinosarcoma in the parotid gland of a 77-year-old man with unusual anaplastic sarcomatoid giant cell morphology. Read More

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November 2020

Osteosarcoma Arising in Carcinosarcoma De Novo Parotid Gland in a Young Man: An Unusual Case with Review of Literature.

J Clin Diagn Res 2017 Apr 1;11(4):ED08-ED10. Epub 2017 Apr 1.

Director Professor, Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Carcinosarcoma of the parotid gland, a true malignant mixed tumour is extremely rare. It may occur in a pre-existing pleomorphic adenoma or arise de novo. We report a case of carcinosarcoma de novo harbouring an osteosarcomatous element in a 35-year-old man along with review of the reported cases. Read More

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Primary Carcinosarcoma of the Parotid Gland Mimicking as Parotid Abscess With Deep Neck Infection.

J Craniofac Surg 2017 May;28(3):e210-e213

Department of Otolaryngology-HNS, Research Institute for Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Chonbuk, Korea.

Carcinosarcoma, true malignant mixed tumor, of the parotid is an extremely rare tumor. Pathologically, it is composed of malignant epithelial and malignant mesenchymal elements. The carcinosarcoma of the salivary glands comprised only 0. Read More

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Primary pure spindle cell carcinoma (sarcomatoid carcinoma) of the ovary: A case report with immunohistochemical study.

Diagn Pathol 2016 Aug 5;11(1):70. Epub 2016 Aug 5.

Department of Biomedical, Biotechnological and Translational Sciences, Pathological Anatomy and Histology Unit, Faculty of Medicine, University of Parma, Parma, Italy.

Background: In the ovary, sarcomatoid carcinoma has been reported only as mural nodules in epithelial malignant or borderline serous or mucinous cystic neoplasms, and in teratomas. In this paper we report a rare case of a solid sarcomatoid carcinoma of the ovary, without accompanying component of giant cells, pleomorphic cells, or glandular and other epithelial structures.

Case Presentation: This case report refers to a sarcomatoid carcinoma of the ovary in in a 57 year-old woman with abdominal pain. Read More

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Mucoepidermoid Carcinoma Associated with Osteosarcoma in a True Malignant Mixed Tumor of the Submandibular Region.

Case Rep Otolaryngol 2015 27;2015:694684. Epub 2015 Oct 27.

Organi di Senso Department, University of "Sapienza", Viale del Policlinico 151, 00161 Rome, Italy.

Introduction. True malignant mixed tumor, also known as carcinosarcoma, is a rare tumor of the salivary gland composed of both malignant epithelial and malignant mesenchymal elements. Frequently carcinosarcoma arises in the background of a preexisting pleomorphic adenoma; however, if no evidence of benign mixed tumor is present, the lesion is known as carcinosarcoma "de novo. Read More

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November 2015

Odontogenic carcinosarcoma of the mandible: a case report and review.

J Korean Assoc Oral Maxillofac Surg 2015 Jun 23;41(3):139-44. Epub 2015 Jun 23.

Department of Pathology, Inha University School of Medicine, Incheon, Korea.

Odontogenic carcinosarcoma is an extremely rare malignant odontogenic tumor with only a few reported cases. It is characterized by a true mixed tumor showing malignant cytology of both epithelial and mesenchymal components. It has been assumed to arise from pre-existing lesions such as ameloblastoma, ameloblastic fibroma, and ameloblastic fibrosarcoma. Read More

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Ovarian carcinosarcoma associated with bilateral tubal intraepithelial carcinoma: a case report.

Int J Gynecol Pathol 2013 Jul;32(4):384-9

Department of Pathology, Landesklinikum Baden-Moedling, Mödling, Austria.

Carcinosarcomas (malignant mixed müllerian tumors) of the ovary are rare tumors. This report describes a case of a 64 years old patient presenting with a large tumor in the true pelvis, intraoperatively originating from the right ovary, with peritoneal metastatic deposits. Histologically, a dominant sarcomatoid component consisted of short spindle and epithelioid round cells. Read More

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Follicular dendritic cell sarcoma of the parotid gland recurring 6 times within 12 years.

J Craniofac Surg 2009 Nov;20(6):2171-2

Department of Otorhinolaryngology, Cerrahpasa School of Medicine, Istanbul University, Istanbul, Turkey.

Follicular dendritic cell sarcoma is a rare neoplasm of low to intermediate malignant potential. It can occur in any location where follicular dendritic cells reside, and nearly all the cases reported in clinical notes have occurred as primary lymph node tumors. Carcinosarcoma or true malignant mixed tumor of the salivary gland is a tumor composed of both carcinomatous and sarcomatous elements. Read More

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November 2009

Fine-needle aspiration biopsy of pleural metastases from a carcinosarcoma or true malignant mixed tumor of the parotid gland mimicking a mesothelioma.

Diagn Cytopathol 2009 Sep;37(9):680-5

Department of Pathology, Tata Memorial Hospital, Parel, Mumbai, India.

Malignant mixed tumor of the parotid is known to have odd sites for metastases. We describe the fine-needle aspiration cytology (FNAC) findings of pleural metastasis from a malignant mixed tumor misdiagnosed as a mesothelioma on cytology at the onset.A 47-year-old man presented to us with breathlessness and a massive pleural effusion with pleural-based nodules. Read More

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September 2009

Laryngeal true malignant mixed tumor.

Head Neck 2009 Apr;31(4):556-60

Department of Otorhinolaryngology-Head and Neck Surgery, University of Ferrara, 44100 Ferrara, Italy.

Background: True malignant mixed tumor, also known as carcinosarcoma, is a salivary gland type malignant neoplasm, which is extremely rare, and only a few cases arising in the larynx have been previously reported.

Methods And Results: We report a case of true malignant mixed tumor arising in the larynx of a 65-year-old woman successfully treated with surgery. Histologically, the neoplasm was composed of variably mixed, neoplastic glandular, spindle, and chondroid tissues. Read More

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Salivary gland carcinosarcoma: oligonucleotide array CGH reveals similar genomic profiles in epithelial and mesenchymal components.

Oral Oncol 2009 Mar 6;45(3):259-65. Epub 2008 Aug 6.

Department of Oral and Maxillofacial Surgery/Oral Pathology, Academic Centre for Dentistry (ACTA), VU University medical center (VUmc), Amsterdam, The Netherlands.

In this study, we present a case of parotid gland de novo carcinosarcoma. Salivary gland carcinosarcoma (or true malignant mixed tumor) is a rare biphasic neoplasm, composed of both malignant epithelial and malignant mesenchymal components. It is yet unclear whether these two phenotypes occur by collision of two independent tumors or if they are of clonal origin. Read More

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[Malignant mixed Müllerian tumor of the urinary bladder].

Pathologe 2008 Sep;29(5):375-7

Institut für Pathologie, Universitätsklinikum Bonn, Sigmund-Freud-Strasse 25, 53127, Bonn.

True mixed epithelial-mesenchymal tumors of the urinary bladder are exceedingly rare, and only two vesical adenosarcomas have been reported to date. These tumors originated from bladder endometriosis, and malignant transformation of endometriosis has been described, with endometrioid and clear-cell carcinomas being the most common malignancies. We report an unusual case of a malignant mixed Müllerian tumor with heterologous rhabdomyoblastic differentiation, which originated in the urinary bladder of a postmenopausal woman. Read More

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September 2008

[Carcinoma ex pleomorphic adenoma of major salivary glands--a clinicopathologic review].

Otolaryngol Pol 2007 ;61(5):687-93

Katedra i Klinika Chorób Uszu, Nosa, Gardła i Krtani AM w Gdańsku.

Background: Pleomorphic adenoma (PA) is the most common neoplasm of the major salivary glands. There are three subtypes of malignant PA: carcinoma ex pleomorphic adenoma (CXPA); carcinosarcoma (true malignant mixed tumor) and metastasizing pleomorphic adenoma. The most common subtype of malignant PA is CXPA which develops in primary or recurrent PA. Read More

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[Carcinosarcoma arising from a preexisting pleomorphic adenoma--true malignant mixed tumor of the parotid gland].

Authors:
Katarzyna Nowak

Otolaryngol Pol 2007 ;61(6):1024-7

Klinika Otolaryngologii i Onkologii Laryngologicznej UM im. Karola Marcinkowskiego w Poznaniu.

Unlabelled: Carcinosarcoma (true malignant mixed tumor) is rare in salivary gland neoplasms. Even rarer is a carcinosarcoma arising from a preexisting pleomorphic adenoma.

Case: a 49-year-old woman was admitted with left neck pain. Read More

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Metastatic benign pleomorphic adenoma. Report of a case and review of the literature.

Med Oral Patol Oral Cir Bucal 2008 Mar 1;13(3):E193-6. Epub 2008 Mar 1.

Maxillofacial Dept., Hospital Universitari Joan XXIII, Tarragona, Spain.

Pleomorphic adenoma (PA), originally called mixed tumour, is the most common neoplasm of the salivary glands and is generally accepted as benign biologically. Occasionally PA may give rise to metastasis. The metastasis may develop in a PA in which a malignant transformation occurs, either arising a carcinoma in the PA (carcinoma ex-mixed tumour) or as a carcinosarcoma (so-called true malignant mixed tumour). Read More

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True malignant mixed tumor of parotid.

Authors:
Asim Qureshi

J Coll Physicians Surg Pak 2007 Nov;17(11):697-8

Department of Pathology and Microbiology, Aga Khan University, Hospital, Karachi.

Carcinosarcoma is a rare malignant neoplasm of salivary glands that manifests both carcinomatous and sarcomatous components. Specimen of a recurrent parotid tumor of a 55-year-old male was received for histopathology. Diagnosis of a biphasic malignant neoplasm was made. Read More

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November 2007

Carcinosarcoma of the parotid gland: report of a case with immunohistochemical findings.

Ann Otol Rhinol Laryngol 2007 Sep;116(9):702-4

Department of Otolaryngology-Head and Neck Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.

Objectives: Carcinosarcoma (true malignant mixed tumor) of the parotid gland is an extremely uncommon tumor composed of both carcinomatous and sarcomatous components. An understanding of this manifestation is crucial to guide management and treatment of this disease.

Methods: A patient who presented with facial nerve weakness and a painful mass of the parotid gland underwent fine needle aspiration, laboratory testing, and computed tomography of the neck that demonstrated a large parotid malignancy. Read More

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September 2007

Tracheal carcinosarcoma (true malignant mixed tumour) in a Belgian Blue heifer.

J Comp Pathol 2005 Feb-Apr;132(2-3):237-41. Epub 2005 Jan 7.

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, University of Ghent, Salisburylaan 133, 9820 Merelbeke, Belgium.

This report describes a case of a carcinosarcoma or true malignant mixed tumour (salivary gland type) of the trachea in a Belgian Blue heifer. At post-mortem examination a nodular, well-circumscribed, firmly attached mass was found in the tracheal wall, severely compressing the tracheal lumen. Histologically the tumour was biphasic, with varying proportions of epithelial elements dispersed throughout a matrix showing varying degrees of myxo-chondroid and cartilaginous differentiation. Read More

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True malignant mixed tumor (carcinosarcoma) of parotid gland : a case report.

Indian J Pathol Microbiol 2004 Jan;47(1):64-6

Department of Pathology, Indira Gandhi Medical College, Shimla.

The malignant mixed tumor (carcinosarcoma) of the salivary gland is an extremely rare tumor. By definition, it is composed of both malignant epithelial and malignant mesenchymal components. We report a case of carcinosarcoma in the parotid gland of a 59 year old man, that arose "de novo" and contained ductal adenocarcinoma as the epithelial component and osteosarcoma and chondrosarcoma as mesenchymal components. Read More

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January 2004

[Malignant mixed tumor].

Gan To Kagaku Ryoho 2004 Mar;31(3):314-7

Dept. of Otorhinolarygology, Chiba National Hospital, 4-1-2 Tsubakimori, Chuo-ku, Chiba 260-8606, Japan.

The term "malignant mixed tumor" is usually synonymous with "carcinoma in pleomorphic adenoma," a secondary carcinoma developing in pre-existing pleomorphic adenoma. However, it sometimes indicates a group of tumors consisting of carcinoma in pleomorphic adenoma, carcinosarcoma (true malignant mixed tumor) and metastasizing benign mixed tumor, the latter 2 being the most infrequent. According to the data of the Japanese committee on TNM classification for salivary gland carcinomas, carcinoma in pleomorphic adenoma accounted for about 10% of all salivary gland carcinomas, both in the parotid and submandibular glands. Read More

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Ameloblastic fibrosarcoma or odontogenic carcinosarcoma: a matter of classification?

Oral Oncol 2004 Apr;40(4):444-9

Department of Oral and Maxillofacial Surgery, University Hospital of Mainz, Augustusplatz 2, 55101 Mainz, Germany.

A biphasic odontogenic tumor with aggressive clinical behaviour is reported. The tumor arose posterior to the right mandibular third molar involving the angle of the mandible and the ascending ramus. Within a 5 years period the patient suffered from two episodes of local progression and final disease generalization occurred 6 years after initial surgical therapy. Read More

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Carcinosarcoma of the submandibular gland: an autopsy case.

Auris Nasus Larynx 2003 Dec;30(4):439-42

Department of Otolaryngology, Head and Neck Surgery, Shiga University of Medical Science, Seta Tsukinowa, Ohtsu, 520-2192, Shiga, Japan.

Malignant mixed tumors of salivary glands are classified as three types:carcinoma arising in a pleomorphic adenoma, the most common; benign metastasizing pleomorphic adenoma; and carcinosarcoma (true malignant mixed tumor), which is very rare [Ann. Otol. Rhinol. Read More

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December 2003

Carcinosarcoma of the parotid gland with epithelial-myoepithelial carcinoma and pleomorphic sarcoma components.

Br J Oral Maxillofac Surg 2002 Dec;40(6):480-3

Department of Oral and Maxillofacial Surgery, Government Dental College Trivandrum, Trivandrum, Kerala, India.

We report a case of true malignant mixed tumour (carcinosarcoma) of the parotid gland with epithelial-myoepithelial carcinoma and pleomorphic sarcomatous components in a 68-year-old woman. The pleomorphic sarcomatous component behaved aggressively with lymph node and distant metastases. The biological behaviour of the individual components in a malignant mixed tumour makes it difficult to diagnose. Read More

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December 2002

True malignant mixed tumor (carcinosarcoma) of parotid gland with unusual mesenchymal component: a case report and review of the literature.

Authors:
M Y Kwon M Gu

Arch Pathol Lab Med 2001 Jun;125(6):812-5

Department of Pathology, University of California Irvine Medical Center, Orange, CA 92868, USA.

True malignant mixed tumor (carcinosarcoma) of the salivary gland is an extremely rare tumor. By definition, it is composed of both malignant epithelial and malignant mesenchymal elements. The most common type of the former is squamous cell carcinoma or adenocarcinoma and the most common type of the latter is chondrosarcoma, followed in frequency by fibrosarcoma, leiomyosarcoma, osteosarcoma, and in rare instances liposarcoma. Read More

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Salivary gland carcinosarcoma: immunohistochemical, molecular genetic and electron microscopic findings.

Oral Oncol 2000 Jul;36(4):360-4

Department of Otolaryngology, Head and Neck Surgery, University Hospital Mannheim, D-68135, Mannheim, Germany.

Salivary gland carcinosarcoma, or true malignant mixed tumor, is a very rare and extremely aggressive neoplasm. The clonality and clonal origin of this tumor are discussed controversially. We report a carcinosarcoma of the left parotid gland in a patient who subsequently died of cutaneous, lymphatic and pulmonary metastases. Read More

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Carcinosarcoma of the submandibular salivary gland.

Eur J Surg Oncol 1999 Jun;25(3):333-5

2nd Propedeutic Department of Surgery, Athens University and Medical School, Laikon Hospital, Greece.

We report a rare case of submandibular salivary gland carcinosarcoma ('true' malignant mixed tumour) which occurred in a 77-year-old man. Microscopic examination showed a neoplasm comprised of sarcomatous elements (chondrosarcoma, rhabdomyosarcoma and osteosarcoma) with tabular salivary ductal adenocarcinoma. A short review of the literature is also presented and the poor prognosis of these tumours, in spite of complete surgical removal and additional radiation therapy and chemotherapy, is discussed. Read More

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Carcinosarcoma of the parotid gland: report of a case with cytohistologic and immunohistochemical findings.

Arch Pathol Lab Med 1998 Aug;122(8):743-6

Department of Pathology, Berkshire Medical Center, Pittsfield, Mass 01201, USA.

True malignant mixed tumors (carcinosarcomas) of salivary gland origin are exceedingly rare and demonstrate malignant epithelial and stromal components. We report a case of parotid gland carcinosarcoma that showed squamous cell carcinoma and malignant fibrous hystiocytoma without clinical or histologic evidence of a preexisting pleomorphic adenoma. This tumor consisted of 2 histologically different populations of cells without evidence of a common origin from the myoepithelial cell, which is the putative precursor cell of pleomorphic adenoma and its derived carcinosarcoma. Read More

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Fine needle aspiration diagnosis of malignant mixed tumor (carcinosarcoma) arising in pleomorphic adenoma of the salivary gland. A case report.

Acta Cytol 1998 Jul-Aug;42(4):1027-31

Department of Pathology, Asan Medical Center, College of Medicine, University of Ulsan, Seoul, Korea.

Background: True malignant mixed tumor (carcinosarcoma), composed of carcinoma and sarcoma components, is rare in salivary gland neoplasms. Even rarer is a true malignant mixed tumor arising in the pleomorphic adenoma of the salivary gland.

Case: A 64-year-old male was admitted with left pharyngeal pain. Read More

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True malignant mixed tumor (carcinosarcoma) of tonsillar minor salivary gland origin: diagnostic imaging and endovascular therapeutic embolization.

AJNR Am J Neuroradiol 1997 Nov-Dec;18(10):1944-8

Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Conn 06520, USA.

We report a case of carcinosarcoma of the minor salivary glands of the left palatine tonsil, an especially rare location. Imaging characteristics assessed at CT, MR imaging, and angiography are presented. In addition, we describe our experience with preoperative therapeutic endovascular embolization of this hypervascular tumor. Read More

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February 1998