158,077 results match your criteria True Malignant Mixed Tumor Carcinosarcoma


Differentiation between persistent infection/colonization and re-infection/re-colonization of Mycobacterium abscessus isolated from patients in Northeast Thailand.

Infect Genet Evol 2018 Dec 3. Epub 2018 Dec 3.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Research and Diagnostic Center for Emerging Infectious Diseases, Khon Kaen University, Khon Kaen, Thailand. Electronic address:

Mycobacterium abscessus can cause true infection or be present in the host as a harmless colonist. The ability of M. abscessus to cause disease and develop drug resistance is known to have a genetic basis. Read More

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December 2018
2 Reads

Reflectance confocal microscopy for diagnosing keratinocyte skin cancers in adults.

Cochrane Database Syst Rev 2018 Dec 3;12:CD013191. Epub 2018 Dec 3.

Institute of Applied Health Research, University of Birmingham, Birmingham, UK, B15 2TT.

Background: Early accurate detection of all skin cancer types is important to guide appropriate management and improve morbidity and survival. Basal cell carcinoma (BCC) is usually a localised skin cancer but with potential to infiltrate and damage surrounding tissue, whereas cutaneous squamous cell carcinoma (cSCC) and melanoma are higher risk skin cancers with the potential to metastasise and ultimately lead to death. When used in conjunction with clinical or dermoscopic suspicion of malignancy, or both, reflectance confocal microscopy (RCM) may help to identify cancers eligible for non-surgical treatment without the need for a diagnostic biopsy, particularly in people with suspected BCC. Read More

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December 2018
4 Reads

Comparison of Three-Dimensional Accuracy of Digital and Conventional Implant Impressions: Effect of Interimplant Distance in an Edentulous Arch.

Int J Oral Maxillofac Implants 2018 Dec 5. Epub 2018 Dec 5.

Purpose: This study compared the three-dimensional (3D) accuracy of conventional impressions with digital impression systems (intraoral scanners and dental laboratory scanners) for two different interimplant distances in maxillary edentulous arches.

Materials And Methods: Six impression systems comprising one conventional impression material(Impregum), two intraoral scanners (TRIOS and True Definition), and three dental laboratory scanners (Ceramill Map400, inEos X5, and D900) were evaluated on two completely edentulous maxillary arch master models (A and B) with six and eight implants, respectively. Centroid positions at the implant platform level were derived using either physical or virtual probe hits with a coordinate measuring machine. Read More

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December 2018
1 Read

Not performing an OGTT results in underdiagnosis, inadequate risk assessment and probable cost increases of (pre)diabetes in Han Chinese over 40 years: a population based prospective cohort study.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

L Chen, Endocrinology, Tongji Hospital affiliated with Tongji Medical School of Huazhong University of Science and Technology, Wuhan, 430022, China.

Screening for (pre)diabetes is recommended in China using fasting blood glucose as routine strategy currently but not oral glucose tolerance test (OGTT) in high-risk population. We aimed to explore the impact by not performing an OGTT in Han Chinese over 40 years. 6682 participants were included in the prospective cohort study followed up for 3 years. Read More

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December 2018
2 Reads

Insights into the evolution of the suppressors of cytokine signalling (SOCS) gene family in vertebrates.

Mol Biol Evol 2018 Dec 5. Epub 2018 Dec 5.

Scottish Fish Immunology Research Centre, Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK.

The SOCS family are key negative regulators of cytokine and growth factor signalling. Typically 8-17 SOCS genes are present in vertebrate species and eight known in mammals, classified as type I (SOCS4-7) and type II (CISH and SOCS1-3) SOCS. It was believed that the type II SOCS were expanded through the two rounds of whole genome duplication (1R and 2R WGDs) from a single CISH/SOCS1-3 precursor. Read More

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December 2018

Gestational Age at Arrest of Development: An Alternative Approach for Assigning Time at Risk in Studies of Time-Varying Exposures and Miscarriage.

Am J Epidemiol 2018 Dec 6. Epub 2018 Dec 6.

Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, Tennessee.

Time between arrest of pregnancy development and miscarriage represents a window in which pregnancy is nonviable and not developing. In effect, the loss has happened and exposures cannot influence its fate. However, epidemiologic studies of miscarriage traditionally use gestational age at miscarriage to assign time in survival analyses, which overestimates duration of exposure and time at risk. Read More

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December 2018

Childhood Hearing Loss in Patients With Sickle Cell Disease in the United States.

J Pediatr Hematol Oncol 2018 Dec 4. Epub 2018 Dec 4.

Departments of Otolaryngology-Head and Neck Surgery.

This study sought to examine if modern medical evaluations including newborn screening and early diagnosis along with better methods of disease control have improved rates of hearing loss in children with sickle cell disease (SCD). Audiometric and medical data for patients with SCD was obtained from the AudGen Database and analyzed for the presence of hearing loss, type of hearing loss, severity of hearing loss, and correlation with comorbid conditions. Children with sickle cell trait (SCT) were used as a comparison group. Read More

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December 2018

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST.

Health Technol Assess 2018 Dec;22(70):1-82

Respiratory Medicine, Nottingham NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK.

Background: Asthma exacerbations affect the quality of life of patients with asthma and have a major effect on the overall costs of asthma care. An asthma self-management plan that advises the temporary quadrupling of inhaled corticosteroid dose may prevent asthma exacerbations, but this needs to be confirmed before being adopted widely.

Objectives: To compare the clinical effectiveness and cost-effectiveness of an asthma self-management plan that advises patients to temporarily quadruple the dose of inhaled corticosteroid when asthma control starts to deteriorate with a standard self-management plan. Read More

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December 2018

Adaptation, chance, and history in experimental evolutionary reversals to unicellularity.

Evolution 2018 Dec 6. Epub 2018 Dec 6.

Department of Ecology, Evolution and Behavior, University of Minnesota, St Paul, Minnesota, 55108.

Evolution is often deemed irreversible. The evolution of complex traits that require many mutations makes their reversal unlikely. Even in simpler traits, reversals might become less likely as neutral or beneficial mutations, with deleterious effects in the ancestral context, become fixed in the novel background. Read More

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December 2018

Validation of the physiological background correction method for the suppression of the spill-in effect near highly radioactive regions in positron emission tomography.

EJNMMI Phys 2018 Dec 5;5(1):34. Epub 2018 Dec 5.

Biomedical Imaging Science Department, School of Medicine, University of Leeds, Leeds, West Yorkshire, UK.

Background: Positron emission tomography (PET) imaging has a wide applicability in oncology, cardiology and neurology. However, a major drawback when imaging very active regions such as the bladder is the spill-in effect, leading to inaccurate quantification and obscured visualisation of nearby lesions. Therefore, this study aims at investigating and correcting for the spill-in effect from high-activity regions to the surroundings as a function of activity in the hot region, lesion size and location, system resolution and application of post-filtering using a recently proposed background correction technique. Read More

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December 2018

EPA's non-targeted analysis collaborative trial (ENTACT): genesis, design, and initial findings.

Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.

National Center for Computational Toxicology, Office of Research & Development, US Environmental Protection Agency, Research Triangle Park, NC, 27711, USA.

In August 2015, the US Environmental Protection Agency (EPA) convened a workshop entitled "Advancing non-targeted analyses of xenobiotic chemicals in environmental and biological media." The purpose of the workshop was to bring together the foremost experts in non-targeted analysis (NTA) to discuss the state-of-the-science for generating, interpreting, and exchanging NTA measurement data. During the workshop, participants discussed potential designs for a collaborative project that would use EPA resources, including the ToxCast library of chemical substances, the DSSTox database, and the CompTox Chemicals Dashboard, to evaluate cutting-edge NTA methods. Read More

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December 2018
1 Read

A validated workflow for drug detection in oral fluid by non-targeted liquid chromatography-tandem mass spectrometry.

Anal Bioanal Chem 2018 Dec 6. Epub 2018 Dec 6.

Institute of Legal Medicine and Core Facility Metabolomics, Medical University of Innsbruck, Muellerstr. 44, 6020, Innsbruck, Austria.

Oral fluid is recognized as an important specimen for drug testing. Common applications are monitoring in substance abuse treatment programs, therapeutic drug monitoring, pain management, workplace drug testing, clinical toxicology, and driving under the influence of drugs (DRUID). In this study, we demonstrate that non-targeted LC-MS/MS with subsequent compound identification by tandem mass spectral library search is a valuable tool for comprehensive detection and confirmation of drugs in oral fluid samples. Read More

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December 2018

False-positive rates in screening for trisomies 18 and 13: a comparison between first-trimester combined screening and a cfDNA-based approach.

Arch Gynecol Obstet 2018 Dec 5. Epub 2018 Dec 5.

Department of Women's Health, University Women's Hospital Tuebingen, Calwerstrasse 7, 72076, Tübingen, Germany.

Purpose: To determine the false-positive rates (FPR) associated with screening for trisomy 18/13 using first-trimester combined screening (FTCS) and an ultrasound plus cfDNA-based approach (US-cfDNA), which includes a detailed ultrasound examination, a cfDNA analysis and a FTCS reflex backup test for cases with uninformative results.

Methods: This is a sub-analysis of a randomized controlled trial, which was performed between 2015 and 2016. Pregnant women with a normal first-trimester ultrasound examination at 11-13 weeks' gestation (NT < 3. Read More

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December 2018

Catheter-Directed Fenestration for Branch Vessel Reconnection in Aortic Dissection Using a Novel Diamond-Tipped Chronic Total Occlusion Drilling Device: A Technical Report.

Cardiovasc Intervent Radiol 2018 Dec 5. Epub 2018 Dec 5.

Interventional Radiology Service - Department of Radiology, Austin Hospital, Heidelberg, Melbourne, VIC, 3084, Australia.

Purpose: Aortic dissection is a complex condition with high morbidity and mortality. Endovascular treatments including percutaneous fenestration can be used to manage branch vessel ischaemia or risk of aortic rupture. A variety of techniques for aortic fenestration have been described. Read More

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December 2018

Influenza vaccination discourse in major Canadian news media, 2017-2018.

Heliyon 2018 Nov 27;4(11):e00970. Epub 2018 Nov 27.

Health Law Institute, University of Alberta Faculty of Law, Edmonton, Alberta, Canada.

Influenza vaccine uptake is less-than-ideal in many jurisdictions, including Canada. In this study we sought to assess news articles relating to influenza vaccination by major Canadian newspapers during a six-month period relatively congruent to the seasonal influenza outbreak for 2017-2018. We identified 116 unique articles published between August 16, 2017 and February 15, 2018, then developed and applied a coding frame to them. Read More

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November 2018

Small copepods could channel missing carbon through metazoan predation.

Ecol Evol 2018 Nov 30;8(22):10868-10878. Epub 2018 Oct 30.

Centre for Applications in Natural Resource Mathematics, School of Mathematics and Physics University of Queensland St Lucia Queensland Australia.

Global ecosystem models are essential tools for predicting climate change impacts on marine systems. Modeled biogenic carbon fluxes in the ocean often match measured data poorly and part of this could be because small copepods (<2 mm) are modeled as unicellular feeders grazing on phytoplankton and microzooplankton. The most abundant copepods from a seasonal upwelling region of the Eastern North Atlantic were sorted, and a molecular method was applied to copepod gut contents to evaluate the extent of metazoan predation under two oceanographic conditions, a trophic pathway not accounted for in global models. Read More

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November 2018

The impact of autotrophic versus heterotrophic nutritional pathways on colony health and wound recovery in corals.

Ecol Evol 2018 Nov 18;8(22):10805-10816. Epub 2018 Oct 18.

Department of Biology Boston University Boston Massachusetts.

For animals that harbor photosynthetic symbionts within their tissues, such as corals, the different relative contributions of autotrophy versus heterotrophy to organismal energetic requirements have direct impacts on fitness. This is especially true for facultatively symbiotic corals, where the balance between host-caught and symbiont-produced energy can be altered substantially to meet the variable demands of a shifting environment. In this study, we utilized a temperate coral-algal system (the northern star coral, and its photosynthetic endosymbiont, ) to explore the impacts of nutritional sourcing on the host's health and ability to regenerate experimentally excised polyps. Read More

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November 2018

Stent-Assisted Angioplasty of Spontaneous Bilateral Extracranial Vertebral Dissections under Intravascular Ultrasound Guidance.

Authors:
Won-Bae Seung

Case Rep Neurol 2018 Sep-Dec;10(3):314-321. Epub 2018 Nov 14.

Department of Neurosurgery, Dongguk University Gyeongju Hospital, Dongguk University College of Medicine, Gyeongju, Republic of Korea.

The authors here report a case of stent-assisted angioplasty under intravascular ultrasound (IVUS) guidance for the treatment of spontaneous bilateral extracranial vertebral artery (VA) dissection. A 47-year-old woman presented with spontaneous severe posterior neck pain. Examinations revealed bilateral extracranial VA dissection, which was thought to be the reason for her symptom. Read More

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November 2018

Colonoscopy-related complications in a nationwide immunochemical fecal occult blood test-based colorectal cancer screening program.

Clin Epidemiol 2018 13;10:1649-1655. Epub 2018 Nov 13.

Department of Digestive Diseases K, Bispebjerg Hospital, Copenhagen, Denmark.

Background: The Danish national screening program for colorectal cancer (CRC) consists of an immunochemical fecal occult blood test (iFOBT) followed by colonoscopy. The Danish Colorectal Cancer Screening Database (DCCSD) records data on the incidence of hospital-registered complications after colonoscopy. However, the validity of these data is unknown, and the incidence of complications is potentially underreported. Read More

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November 2018

Genetic identification of Ly75 as a novel quantitative trait gene for resistance to obesity in mice.

Sci Rep 2018 Dec 5;8(1):17658. Epub 2018 Dec 5.

Laboratory of Animal Genetics and Breeding, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa-ku, Nagoya, 464-8601, Japan.

Identification of causal quantitative trait genes (QTGs) governing obesity is challenging. We previously revealed that the lymphocyte antigen 75 (Ly75) gene with an immune function is a putative QTG for Pbwg1.5, a quantitative trait locus (QTL) for resistance to obesity found from wild mice (Mus musculus castaneus). Read More

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December 2018

Simple multi-wavelength imaging of birefringence:case study of silk.

Sci Rep 2018 Dec 5;8(1):17652. Epub 2018 Dec 5.

Tokyo Institute of Technology, Meguro-ku, Tokyo, 152-8550, Japan.

Polarised light imaging microscopy, with the addition of a liquid crystal (LC) phase retarder, was used to determine the birefringence of silk fibres with high (∼1 μm) spatial resolution. The measurement was carried out with the silk fibres (the optical slow axis) and the slow axis of the LC-retarder set at parallel angles. The direct fit of the transmission data allowed for high fidelity determination of the birefringence Δn ≈ 1. Read More

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December 2018

Treatment duration with immune-based therapies in Cancer: an enigma.

J Immunother Cancer 2018 Dec 5;6(1):143. Epub 2018 Dec 5.

Palo Alto Veterans Affairs Hospital, 3801 Miranda Ave, Palo Alto, CA, 94304, USA.

Unlike chemotherapy treatments that target the tumor itself (rather nonspecifically), immune-based therapies attempt to harness the power of an individual patient's immune system to combat cancer. Similar to chemotherapeutic agents, the dosage and Administration section of labeling for all five currently approved PD-1/PD-L1 inhibitors (immunotherapy) recommends duration of treatment until disease progression or unacceptable toxicity. Overactivation or constitutive activation of the immune system with immune based therapies can lead to T-cell exhaustion and activation induced cell death (AICD) in T- and B-cells. Read More

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December 2018
1 Read

Is the reported increase in young female hospital-treated intentional self-harm real or artefactual?

Aust N Z J Psychiatry 2018 Dec 5:4867418815977. Epub 2018 Dec 5.

1 School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW, Australia.

Background:: The Australian Institute of Health and Welfare has reported an increased rate of hospital-treated intentional self-harm in young females (2000-2012) in Australia. These reported increases arise from institutional data that are acknowledged to underestimate the true rate, although the degree of underestimation is not known.

Objective:: To consider whether the reported increase in young females' hospital-treated intentional self-harm is real or artefactual and specify the degree of institutional underestimation. Read More

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December 2018

Bioactive Secondary Metabolites from Octocoral-Associated Microbes-New Chances for Blue Growth.

Mar Drugs 2018 Dec 4;16(12). Epub 2018 Dec 4.

Institute for Bioengineering and Biosciences (iBB), Instituto Superior Técnico (IST), Universidade de Lisboa, 1049-001 Lisbon, Portugal.

Octocorals (Cnidaria, Anthozoa Octocorallia) are magnificent repositories of natural products with fascinating and unusual chemical structures and bioactivities of interest to medicine and biotechnology. However, mechanistic understanding of the contribution of microbial symbionts to the chemical diversity of octocorals is yet to be achieved. This review inventories the natural products so-far described for octocoral-derived bacteria and fungi, uncovering a true chemical arsenal of terpenes, steroids, alkaloids, and polyketides with antibacterial, antifungal, antiviral, antifouling, anticancer, anti-inflammatory, and antimalarial activities of enormous potential for blue growth. Read More

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December 2018

Incentive Strategies for Low-Carbon Supply Chains with Asymmetric Information of Carbon Reduction Efficiency.

Int J Environ Res Public Health 2018 Dec 4;15(12). Epub 2018 Dec 4.

College of Management and Economics, Tianjin University, Tianjin 300072, China.

Information concerning carbon reduction efficiency is of great significance to supply chain operations. Considering the impact of information asymmetry on the performance of low-carbon supply chain, we therefore analyze a chain system with a single product designer and a single manufacturer. The manufacturer owns information on carbon reduction efficiency, whereas the product designer only knows that the carbon reduction efficiency of the manufacturer is either high or low. Read More

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December 2018

The Impact of Tumor Eco-Evolution in Renal Cell Carcinoma Sampling.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Pathology, Cruces University Hospital, Biomarkers in Cancer Unit, Biocruces-Bizkaia Health Research Institute, Plaza de Cruces s/n, 48903 Barakaldo, Bizkaia, Spain.

Malignant tumors behave dynamically as cell communities governed by ecological principles. Massive sequencing tools are unveiling the true dimension of the heterogeneity of these communities along their evolution in most human neoplasms, clear cell renal cell carcinomas (CCRCC) included. Although initially thought to be purely stochastic processes, very recent genomic analyses have shown that temporal tumor evolution in CCRCC may follow some deterministic pathways that give rise to different clones and sub-clones randomly spatially distributed across the tumor. Read More

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December 2018

A coupled multivariate statistics, geostatistical and machine-learning approach to address soil pollution in a prototypical Hg-mining site in a natural reserve.

Chemosphere 2018 Nov 26;218:767-777. Epub 2018 Nov 26.

INDUROT and Environmental Technology, Biotechnology, and Geochemistry Group, Universidad de Oviedo, Campus de Mieres, 33600 Mieres, Asturias, Spain. Electronic address:

The impact of mining activities on the environment is vast. In this regard, many mines were operating well before the introduction of environmental law. This is particularly true of cinnabar mines, whose activity has declined for decades due to growing public concern regarding Hg high toxicity. Read More

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November 2018

Prediction error connectivity: A new method for EEG state analysis.

Neuroimage 2018 Nov 30. Epub 2018 Nov 30.

Epilepsy Unit - Neurology Dept. Hospital del Mar - Parc de Salut Mar, Barcelona, Spain; IMIM - Hospital del Mar Medical Research Institute, Barcelona, Spain.

Several models have been proposed to explain brain regional and interregional communication, the majority of them using methods that tap the frequency domain, like spectral coherence. Considering brain interareal communication as binary interactions, we describe a novel method devised to predict dynamics and thus highlight abrupt changes marked by unpredictability. Based on a variable-order Markov model algorithm developed in-house for data compression, the prediction error connectivity (PEC) estimates network transitions by calculating error matrices (EMs). Read More

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November 2018

Re-examining the relationship between alcohol consumption and coronary heart disease with a new lens.

Prev Med 2018 Nov 30. Epub 2018 Nov 30.

Epidemiology and Biometry Branch, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United States.

Moderate alcohol consumption has been related to lower risk of coronary heart disease (CHD) in the literature. To examine whether alcohol drinking during the past 12 months and heaviest drinking period were differentially associated with the risk of CHD, we designed a case-control study using a population-based health survey of U.S. Read More

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November 2018

Fluorescence guided sentinel lymph node mapping: from current molecular probes to future multimodal nanoprobes.

Bioconjug Chem 2018 Dec 3. Epub 2018 Dec 3.

For SLN lymph node biopsy (SLNB), the SLN mapping has become a standard of care procedure that can accurately locate the micrometastases disseminated from primary tumor sites to the regional lymph nodes. The broad array of SLN mapping has prompted the development of a wide range of SLN tracers, rationally designed for noninvasive, and high-resolution imaging of SLNs. At present, conventional SLN imaging probes (blue dyes, radiocolloids and few other small-molecular dyes) although serves the clinical needs, these are often associated with major issues such as insufficient accumulation in SLN, short retention time, staining of the surgical field and other adverse side effects. Read More

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December 2018

When Office Blood Pressure is not Enough: The Case of Masked Hypertension.

Am J Hypertens 2018 Dec 3. Epub 2018 Dec 3.

Department of Health Science, University of Milano-Bicocca, Milano, Italy.

An increasing attention has been devoted in the last two decades to masked hypertension (MH), a condition characterized by the fact that classification of a normal blood pressure (BP) status by office measurements is not confirmed by home and/or ambulatory BP monitoring (ABPM).MH definition (i.e. Read More

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December 2018

β-composite Interval Mapping for robust QTL analysis.

PLoS One 2018 3;13(12):e0208234. Epub 2018 Dec 3.

Department of Statistics, University of Rajshahi, Rajshahi, Bangladesh.

Interval mapping approaches have been playing significant role for quantitative trait locus (QTL) mapping to discover genetic architecture of diseases or traits with molecular markers. Composite interval mapping (CIM) is one of the superior approaches of the interval mapping for discovering both linked and unlinked putative QTL positions. However, estimators of this approach are not robust against phenotypic outliers. Read More

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December 2018
1 Read

Screening for Elevated Blood Lead Levels: False-Positive Rates of Tests on Capillary Samples, Minnesota, 2011-2017.

J Public Health Manag Pract 2019 Jan/Feb;25 Suppl 1, Lead Poisoning Prevention:S44-S50

Environmental Health Division, Minnesota Department of Health, St Paul, Minnesota.

Context: A typical strategy for identifying children with elevated blood lead levels (BLL) is to use a test on a capillary sample as a screening tool and then perform a confirmatory test on a venous sample following an elevated capillary screen. However, tests on capillary samples are prone to false-positive results, which affect surveillance estimates of the prevalence of elevated BLL.

Objective: We sought to measure the prevalence and risk of false-positive results in elevated tests on capillary samples based on various potential predictors. Read More

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December 2018

Lymphoganuloma venereum in the Western world, 15 years after its re-emergence: new perspectives and research priorities.

Curr Opin Infect Dis 2018 Nov 30. Epub 2018 Nov 30.

Department of Infectious Diseases, STI Outpatient Clinic, Public Health Service of Amsterdam.

Purpose Of Review: Lymphogranuloma venereum (LGV) is a serious sexually transmitted infection caused by Chlamydia trachomatis. If left untreated LGV can cause irreversible late sequelae. LGV is endemic among a high-risk population of men who have sex with men (MSM), and largely reported in Western metropoles. Read More

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November 2018
1 Read

Using structured data entry systems in the electronic medical record to collect clinical data for quality and research: Can we efficiently serve multiple needs for complex patients with spina bifida?

J Pediatr Rehabil Med 2018 Nov 19. Epub 2018 Nov 19.

Division of Urology, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Purpose: The era of the electronic health record (EHR) generates the ability to systematically collect and record innumerable data for complex procedures such as videourodynamic studies (VUDS). We developed a Structured Data Entry System (SDES) that would serve as a way to better standardize VUDS for both quality improvement and research capabilities.

Methods: A working group convened to design a SDES form for VUDS in a flow sheet format in our hospital's EHR, allowing for easy integration of the information into the clinical encounter note and for weekly export of data to clinicians in spreadsheet form. Read More

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November 2018

Improvement in Recovery of Hemodynamic Responses by Extended Kalman Filter with Non-Linear State-Space Model and Short Separation Measurement.

IEEE Trans Biomed Eng 2018 Nov 30. Epub 2018 Nov 30.

Objective: The purpose of this study is to describe the noise reduction in the hemodynamic responses, obtained by functional near-infrared spectroscopy (fNIRS), using the proposed extended Kalman filter (EKF) with a non-linear state-space model, aided by the short separation (SS) measurement.

Methods: The authors used the simulated data by adding the synthetic hemodynamic response function (HRF) to the multi-distance four-channel fNIRS signals obtained during the resting state. EKF was used to estimate the non-linear state-space model designed based on Balloon model. Read More

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November 2018

Peak power output in handcycling of individuals with a chronic spinal cord injury: predictive modeling, validation and reference values.

Disabil Rehabil 2018 Dec 3:1-10. Epub 2018 Dec 3.

b Center for Human Movement Sciences, University Medical Center Groningen, University of Groningen , Groningen , The Netherlands.

Purpose: To develop and validate predictive models for peak power output to provide guidelines for individualized handcycling graded exercise test protocols for people with spinal cord injury (SCI); and to define reference values.

Materials And Methods: Power output was measured in 128 handcyclists with SCI during a synchronous handcycling exercise test. Eighty percent of the data was used to develop four linear regression models: two theoretical and two statistical models with peak power output (in W and W/kg) as dependent variable. Read More

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December 2018

Metabolic Signatures of Cystic Fibrosis Identified in Dried Blood Spots For Newborn Screening Without Carrier Identification.

J Proteome Res 2018 Dec 3. Epub 2018 Dec 3.

Cystic fibrosis (CF) is a complex multi-organ disorder that is among the most common fatal genetic diseases benefiting from therapeutic interventions early in life. Newborn screening (NBS) for pre-symptomatic detection of CF currently relies on a two-stage immunoreactive trypsinogen (IRT) and cystic fibrosis transmembrane conductance regulator (CFTR) mutation panel algorithm that is sensitive, but not specific for identifying affected neonates with a low positive predictive value. For the first time, we report the discovery of a panel of CF-specific metabolites from a single 3. Read More

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December 2018

Real-time simultaneous shim and motion measurement and correction in glycoCEST MRI using double volumetric navigators (DvNavs).

Magn Reson Med 2018 Dec 2. Epub 2018 Dec 2.

UCT Medical Imaging Research Unit, Division of Biomedical Engineering, Department of Human Biology, University of Cape Town, Cape Town, South Africa.

Purpose: CEST MRI allows for indirect detection of molecules with exchangeable protons, measured as a reduction in water signal because of continuous transfer of saturated protons. CEST requires saturation pulses on the order of a second, as well as repeated acquisitions at different offset frequencies. The resulting extended scan time makes CEST susceptible to subject motion, which introduces field inhomogeneity, shifting offset frequencies and causing distortions in CEST spectra that resemble true CEST effects. Read More

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December 2018

[Application of intraoperative ultrasound in laparoscopic lymphadenectomy of gastric cancer].

Zhonghua Wei Chang Wai Ke Za Zhi 2018 Nov;21(11):1268-1273

Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy, Hefei 230001, China.

Objective: To explore the application value of intraoperative ultrasound (IU) in laparoscopic lymphadenectomy of gastric cancer.

Methods: Patients with gastric cancer undergoing laparoscopic radical D2 gastrectomy at General Surgery of the Second Affiliated Hospital of Anhui Medical University between August 2016 and May 2018 were prospectively enrolled and were randomly divided into IU group (n=78) and conventional group (n=91). The conventional group underwent laparoscopy only. Read More

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November 2018

[Patient involvement: challenges for organized self-help and joint self-government].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2018 Nov 30. Epub 2018 Nov 30.

Institut für Public Health und Pflegeforschung, Universität Bremen, Bremen, Deutschland.

The involvement of the patient perspective in decision-making processes in the healthcare system is commonly welcome, especially in Germany, with self-help organizations currently providing the vast majority of patient representatives in the various committees. The central plank of organized self-help is the mutual support of chronically diseased and disabled people as well as their relatives in self-help groups.Patient involvement, however, seems to lead organized self-help to an insoluble dilemma. Read More

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November 2018

Developing and validating a checklist for accreditation in leadership and management of hospitals in Iran.

J Educ Health Promot 2018 29;7:136. Epub 2018 Oct 29.

Department of Health Services Management, School of Health Management and Information, Iran University of Medical Sciences, Tehran, Iran.

Introduction: In the Iranian Accreditation System, leadership and management standards have been almost ignored and not paid enough and necessary attention to the structural components and the infrastructures standards in management and leadership sections. Governing body, medical staff, chief executive officer (CEO), and nursing management standards are inadequate and lack accountability. These standards could lead to reform and finally provide the context for accomplishment of an appropriate accreditation program. Read More

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October 2018

Overlooked gall-inducing moths revisited, with the description of gen. et sp. n. and sp. n. from Chile (Lepidoptera, Cecidosidae).

Zookeys 2018 12(795):127-157. Epub 2018 Nov 12.

Department of Entomology, National Museum of Natural History, Smithsonian Institution, Washington, DC 37012-7012, USA.

There are still many gall systems associated with larvae of Lepidoptera in which the true gall-inducers have not been identified to species. Reports on misidentification of gall inducers have been recurrent for these galls, particularly in complex gall-systems that may include inquilines, kleptoparasites, and cecidophages, among other feeding guilds such as predators and parasitoid wasps. Here we describe and illustrate the adults, larvae, pupae and galls, based on light and scanning microscopy, of and , two sympatric cecidosid moths that are associated with (Cav. Read More

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November 2018

Disease Pattern among Sexually Transmitted Infection Clinic Attendees: A Hospital-Based Study.

Indian J Dermatol 2018 Nov-Dec;63(6):502-505

Department of Pediatrics, Base Hospital, New Delhi, India.

Background: Sexually transmitted infections (STIs) have a definite role in the facilitation of HIV infection, which, in turn, also increases susceptibility to other STIs. Further, the social stigma and secrecy surrounding STIs create difficulty in estimating its true incidence and prevalence.

Objective: The objective of this study was to know the pattern of diseases including different clinical presentations and final diagnosis among the STI clinic attendees. Read More

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December 2018

Critical Care Nurses' Reasons for Working or Not Working Overtime.

Crit Care Nurse 2018 Dec;38(6):47-57

Vanessa M. Lobo develops workshops for clinicians and teaches in Health Organization Management at the Canadian University Dubai, Dubai, United Arab Emirates. Jenny Ploeg is a professor in the School of Nursing and associate member, Department of Health, Aging and Society, McMaster University, Hamilton, Ontario. She is scientific director of the Aging, Community and Health Research Unit, School of Nursing, McMaster University. Anita Fisher is an associate professor in the School of Nursing, Faculty of Health Science at McMaster University. Gladys Peachey is retired from the faculty of Nursing at McMaster University. Noori Akhtar-Danesh is an associate professor of biostatistics, School of Nursing, McMaster University.

Background: Around the world, registered nurses are working increasing amounts of overtime. This is particularly true in critical care environments, which experience unpredictable fluctuations in patient volume and acuity, combined with a need for more specialized nurses.

Objective: To explore critical care nurses' reasons for working or not working overtime. Read More

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December 2018

A brief, but comprehensive, guide to clonal evolution in aplastic anemia.

Authors:
Daria V Babushok

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):457-466

Division of Hematology-Oncology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA; and.

Acquired aplastic anemia (AA) is an immune-mediated bone marrow aplasia that is strongly associated with clonal hematopoiesis upon marrow recovery. More than 70% of AA patients develop somatic mutations in their hematopoietic cells. In contrast to other conditions linked to clonal hematopoiesis, such as myelodysplastic syndrome (MDS) or clonal hematopoiesis of indeterminate potential in the elderly, the top alterations in AA are closely related to its immune pathogenesis. Read More

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November 2018
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Complement-driven anemia: more than just paroxysmal nocturnal hemoglobinuria.

Hematology Am Soc Hematol Educ Program 2018 Nov;2018(1):371-376

Division of Hematology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.

Atypical hemolytic uremic syndrome (aHUS); hemolysis, elevated liver function tests, and low platelets syndrome; and transplant-associated thrombotic microangiopathy are related conditions, in that many patients harbor germline heterozygous mutations in genes that regulate the alternative pathway of complement (APC). Penetrance is variable because development of clinically significant disease appears to require supervention of a process such as inflammation. Complement activation on the endothelial surfaces leads to endothelial damage, platelet consumption, microthrombi, and a mechanical hemolytic anemia with schistocytes. Read More

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November 2018

Treatment of Patients with Vocal Fold Atrophy and Comorbid Essential Voice Tremor: Long-Term Injection Augmentation Outcomes After Successful Diagnostic Vocal Fold Injection Augmentation.

J Voice 2018 Nov 29. Epub 2018 Nov 29.

Division of Otolaryngology, Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts. Electronic address:

Objective: Vocal fold injection augmentation (VFIA) is employed diagnostically for patients with subtle glottic insufficiency. Its use in patients with both vocal fold atrophy and benign essential voice tremor (EVT) has been reported but not after durable augmentation. This study intends to evaluate the success of durable VFIA using either autologous fat or calcium hydroxylapatite in patients with both vocal fold atrophy and comorbid EVT. Read More

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November 2018