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Semin Neurol 2018 Dec 6;38(6):640-643. Epub 2018 Dec 6.
Department of Neurology, Boston University School of Medicine, Boston, Massachusetts.
Myofascial pain syndromes arise from acute and chronic musculoskeletal pain and often have a referred neuropathic component. It affects more than three quarters of the world's population and is one of the most important and overlooked causes of disability. The origins of pain are thought to reside anywhere between the motor end plate and the fibrous outer covering of the muscle, with involvement of microvasculature and neurotransmitters at the cellular level. Read More
Biochim Biophys Acta Mol Cell Res 2018 Dec 3. Epub 2018 Dec 3.
Secretory Physiology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address:
The intracellular calcium signaling processes are tightly regulated to ensure the generation of calcium signals with the specific spatiotemporal characteristics that are required for regulating various cell functions. Compartmentalization of the molecular components involved in generating these signals at discrete intracellular sites ensures the signaling specificity and transduction fidelity of the signal for regulating downstream effector processes. Store-operated calcium entry (SOCE) is ubiquitously present in cells and is critical for essential cell functions in a variety of tissues. Read More
J Hepatol 2018 Dec 3. Epub 2018 Dec 3.
AP-HP Hôpital Paul-Brousse, Centre Hépato-Biliaire, Liver Intensive Care Unit, Villejuif, F-94800, France; INSERM, Unité 1193, Université Paris-Saclay, Villejuif, F-94800, France; DHU Hepatinov, Villejuif, F-94800, France.
Severe acute liver injury (sALI) is a grave complication of exertional heatstroke (EH). Liver transplantation (LT) may be a therapeutic option, but the criteria for, and timing of transplantation have not been clearly established. The aim of this study was to define the profile of patients who require transplantation in this context. Read More
Arch Biochem Biophys 2018 Dec 3. Epub 2018 Dec 3.
Centers for Metabolic Disease Research, Cardiovascular Research, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, 19140, USA. Electronic address:
Mitochondria are capable of detecting cellular insults and orchestrating inflammatory responses. Mitochondrial reactive oxygen species (mtROS) are intermediates that trigger inflammatory signaling cascade in response to our newly proposed conditional DAMP (damage associated molecular patterns). We recently reported that increased proton leak regulates mtROS generation and thereby exert physiological and pathological activation of endothelial cells. Read More
Langmuir 2018 Dec 6. Epub 2018 Dec 6.
We discuss the role of the metal-ligand (M-L) interfaces in the chemistry of ligand protected, atomically precise noble metal clusters, a new and expanding family of nanosystems, in solution as well as in gas phase. A few possible mechanisms in which the structure and dynamics of M-L interfaces could trigger intercluster exchange reactions are presented first. How interparticle chemistry can be a potential mechanism of Ostwald ripening, a well-known particle coarsening process, is also discussed. Read More
Hum Reprod 2018 Dec 6. Epub 2018 Dec 6.
Graduate School of Health Sciences, Koc University, Davutpasa, Topkapi, Istanbul, Turkey.
Study Question: Are there any differences in the molecular characteristics of the luteal granulosa cells (GC) obtained from stimulated versus non-stimulated (natural) IVF cycles that may help explain the defective luteal phase in the former?
Summary Answer: Luteal GC of stimulated IVF cycles, particularly those of agonist-triggered antagonist cycles, are less viable ex vivo, express LH receptor and anti-apoptotic genes at lower levels, undergo apoptosis earlier and fail to maintain their estradiol (E2) and progesterone (P4) production in comparison to natural cycle GC.
What Is Known Already: Luteal function is defective in stimulated IVF cycles, which necessitates P4 and/or hCG administration (known as luteal phase support) in order to improve clinical pregnancy rates and prevent miscarriage. The luteal phase becomes shorter and menstruation begins earlier than a natural cycle if a pregnancy cannot be achieved, indicative of early demise of corpus luteum (premature luteolysis). Read More
Anatol J Cardiol 2018 Dec 6. Epub 2018 Dec 6.
Department of Cardiology, Faculty of Medicine, İstanbul University, Institute of Cardiology; İstanbul-Turkey.
Objective: Acute heart failure (AHF) is a life-threatening clinical syndrome characterized by rapid onset of heart failure (HF) symptoms and signs and requires urgent therapy. The aim of the present study was to evaluate the overall clinical characteristics, management, and in-hospital outcomes of hospitalized patients with AHF in a large sample of Turkish population.
Methods: The Journey HF-TR study is a cross-sectional, multicenter, non-invasive and observational trial. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
College of Veterinary Medicine, Gansu Agriculture University, Lanzhou, China.
Oxoglutarate receptor 1 (OXGR1), as one of the intermediates in G protein-coupled receptors (GPCRs), plays a crucial role in the citric acid cycle receptor of α-ketoglutarate and metabolism. GPCR can control the cell proliferation by regulating the downstream signaling of G protein signaling pathways. The PI3K/AKT pathway transmits the downstream signals of GPCRs and receptor tyrosine kinases. Read More
J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.
Department of Orthopedics, Hanzhong Central Hospital, Hanzhong, Shanxi, China.
N-acetylcysteine (NAC), a precursor for glutathione (GSH), causes permeable antioxidation protecting normal cells and disrupting cancer cells. In the present study, we found that a NAC-based medium can trigger a reversal response of human clear cell renal cell carcinoma (ccRCC). To further investigate the action of a NAC-based solution in ccRCC cell lines, 786-O and SN12C were incubated in a serum-free acid medium (low pH) in the presence of 2 mM NAC for 24 hours or in a serum-free medium (normal pH) as the control, and then a phenotypic and proteomic analyses were performed. Read More
Heliyon 2018 Nov 22;4(11):e00936. Epub 2018 Nov 22.
King Abdullah University of Science and Technology (KAUST), BESE Division, The BioActives Lab, Thuwal, 23955-6900, Saudi Arabia.
Strigolactones (SLs), a novel class of plant hormones, are key regulator of plant architecture and mediator of biotic interactions in the rhizosphere. Root-released SLs initiate the establishment of arbuscular mycorrhizal (AM) symbiosis by inducing spore germination and hyphal branching in AM fungi (AMF). However, these compounds also trigger the germination of root parasitic weeds, paving the way for deleterious infestation. Read More
Ecol Evol 2018 Nov 18;8(22):11199-11212. Epub 2018 Oct 18.
Graduate School of Science and Technology Shinshu University Matsumoto Japan.
Tree species of three growth forms (evergreen conifers, deciduous hardwoods, and evergreen hardwoods) codominate at the northern distribution limit of evergreen hardwoods in central Japan. This study examined the stand dynamics and competition during 13 years at a single plot to reveal how three growth forms codominate at the ecotone. Species were characterized as large DBH and low tree density for evergreen conifers, and conversely for evergreen hardwoods. Read More
Front Immunol 2018 21;9:2701. Epub 2018 Nov 21.
Department of Bacteriology and Immunology, and Research Programs Unit, Immunobiology, University of Helsinki, Helsinki, Finland.
The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma. Although complement is known to play a role in atherosclerosis, the mechanisms of its contribution are not fully understood. Read More
Int J Nanomedicine 2018 9;13:7303-7318. Epub 2018 Nov 9.
Department of Toxicology and Sanitary Chemistry, School of Public Health, Capital Medical University, Beijing, PR China,
Background: As a promising nanocarrier in biomedical fields, silica nanoparticles (SiNPs) could transfer from the circulatory system to multiple organs. Among these, blood-liver molecular exchange is a critical factor in biological response to NPs. However, the potential effect of SiNPs on hepatic lipid metabolism is unclear. Read More
Cell Death Dis 2018 Dec 5;9(12):1181. Epub 2018 Dec 5.
Department of Immunology, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575, Japan.
Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Read More
Nature 2018 Dec 5. Epub 2018 Dec 5.
Department of Neuroscience, The Kavli Institute for Brain Science, Mortimer B. Zuckerman Mind Brain Behavior Institute, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Although the hippocampus is known to be important for declarative memory, it is less clear how hippocampal output regulates motivated behaviours, such as social aggression. Here we report that pyramidal neurons in the CA2 region of the hippocampus, which are important for social memory, promote social aggression in mice. This action depends on output from CA2 to the lateral septum, which is selectively enhanced immediately before an attack. Read More
Nat Commun 2018 Dec 5;9(1):5185. Epub 2018 Dec 5.
Department of Biosciences, Durham University, Stockton Road, Durham, DH1 3LE, UK.
Detection of conserved microbial patterns by host cell surface pattern recognition receptors (PRRs) activates innate immunity. The FLAGELLIN-SENSITIVE 2 (FLS2) receptor perceives bacterial flagellin and recruits another PRR, BAK1 and the cytoplasmic-kinase BIK1 to form an active co-receptor complex that initiates antibacterial immunity in Arabidopsis. Molecular mechanisms that transmit flagellin perception from the plasma-membrane FLS2-associated receptor complex to intracellular events are less well understood. Read More
Circ J 2018 Dec 6. Epub 2018 Dec 6.
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine.
Background: It has been suggested that protein directly activated by cAMP (Epac), one of the downstream signaling molecules of β-adrenergic receptor (β-AR), may be an effective target for the treatment of arrhythmia. However, there have been no reports on the anti-arrhythmic effects or cardiac side-effects of Epac1 inhibitors in vivo. Methods and Results: In this study, the roles of Epac1 in the development of atrial and ventricular arrhythmias are examined. Read More
Endocr J 2018 Dec 4. Epub 2018 Dec 4.
Department of Metabolism & Endocrinology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Although metabolic abnormalities commonly occur in non-obese Asians, their pathogenesis is not fully understood. Proton magnetic resonance spectroscopy has been used to analyze intracellular lipids in humans, and results suggest that ectopic fat accumulation in muscle and liver may induce insulin resistance in each tissue independently of obesity. Thus, measurement of ectopic fat currently plays an important role in the study of insulin resistance in non-obese Asians. Read More
Int Heart J 2018 Dec 5. Epub 2018 Dec 5.
Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui.
Prostate cancer is the most common non-cutaneous malignancy in men and has been steadily rising in an aging society. Medical castration therapy is effective for metastatic prostate cancer, but the proarrhythmic properties have not been reported. We present a 71-year-old Japanese man with metastasis prostate cancer that, during medical castration therapy, had torsades de pointes (TdP) with a QT prolongation and ventricular fibrillation (VF). Read More
Mar Drugs 2018 Dec 4;16(12). Epub 2018 Dec 4.
Institute for Inorganic and Analytical Chemistry, Bioorganic Analytics, Friedrich Schiller University Jena, Lessingstr. 8, D-07743 Jena, Germany.
Algicidal bacteria can lyse microalgal blooms and trigger shifts within plankton communities. Resistant algal species can escape lysis, and have the opportunity to dominate the phytoplankton after a bacterial infection. Despite their important function in ecosystem regulation, little is known about mechanisms of resistance. Read More
J Inorg Biochem 2018 Nov 28;191:126-134. Epub 2018 Nov 28.
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, PR China. Electronic address:
The chemical structures of Ru (II) complexes are known to affect their cellular behavior and toxicity. In this study, three new luminescent Ru (II) complexes, [Ru(bpy)(HIPMP)](ClO) (Ru1, bpy = 2,2'-bipyridine, HIPMP = 2-(1H-imidazo-[4,5-f] [1,10] phenanthrolin-2-yl)-4-methylphenol), [Ru(phen)(HIPMP)](ClO) (Ru2, phen = 1,10-phenanthroline), [Ru(dmb)(HIPMP)](ClO) (Ru3, dmb = 4,4'-dimethyl-2,2'-bipyridine), were synthesized, and their anticancer activities were examined. All three complexes displayed anticancer activities against various cancer cells, with Ru2 exhibiting the highest cytotoxic activities. Read More
Redox Biol 2018 Nov 20;20:544-555. Epub 2018 Nov 20.
Department of Biology, College of Natural Sciences, Kyungpook National University, Daegu, Republic of Korea; School of Life Sciences, KNU Creative BioResearch Group (BK21 Plus Project), Kyungpook National University, Daegu, Republic of Korea. Electronic address:
Mitochondrial NADP-dependent isocitrate dehydrogenase 2 (IDH2) is a major NADPH-producing enzyme which is essential for maintaining the mitochondrial redox balance in cells. We sought to determine whether IDH2 deficiency induces mitochondrial dysfunction and modulates auditory function, and investigated the protective potential of an antioxidant agent against reactive oxygen species (ROS)-induced cochlear damage in Idh2 knockout (Idh2) mice. Idh2 deficiency leads to damages to hair cells and spiral ganglion neurons (SGNs) in the cochlea and ultimately to apoptotic cell death and progressive sensorineural hearing loss in Idh2 mice. Read More
Appetite 2018 Nov 30. Epub 2018 Nov 30.
Department of Psychology, Memorial University of Newfoundland, St. John's, NL, Canada.
'Food addiction' refers to the idea that certain highly palatable foods can trigger an addictive-like process in susceptible individuals. The aim of this study was to assess the prevalence and clinical significance of 'food addiction' symptoms in binge eating disorder (BED) using the second version of the Yale Food Addiction Scale (YFAS 2.0). Read More
Brain Res Bull 2018 Nov 30. Epub 2018 Nov 30.
Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing medical university, Chongqing, 400016, China. Electronic address:
Individuals with intracerebral hemorrhage (ICH) suffer varying degrees of neurological dysfunction as a result of neuronal apoptosis, and thus, maintenance of neuronal survival may be crucial to prevent ICH brain injury. Here, we report that the expression of transient receptor potential vanilloid 4 (TRPV4) was upregulated in mouse neurons after ICH. The selective TRPV4 agonist GSK1016790 A aggravated neuronal death whereas the TRPV4 antagonist HC-067047 promoted neuronal survival after ICH. Read More
Transpl Immunol 2018 Nov 30. Epub 2018 Nov 30.
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka 812-8582, Japan.
Background: Although high-mobility group box-1 (HMGB1), which is a nuclear protein, was reported to enhance the allogeneic responses in transplantation, the effect of HMGB1 on bronchiolitis obliterans syndrome (BOS) is unknown.
Methods: A murine heterotopic tracheal transplantation model was used. Protein concentrations of HMGB1, interferon-γ (IFN-γ), interleukin (IL)-10, and IL-17 were analyzed in the isografts, allografts, controls, and HMGB1-neutralizing antibody administered allografts (n = 6; Days 1, 3, 5, 7, 14, 21, and 28). Read More
Biochem Pharmacol 2018 Nov 30. Epub 2018 Nov 30.
Department of Pharmacology, New York Medical College, 15 Dana Road, Valhalla, 10595, NY, the US. Electronic address:
Ionizing radiation (IR) leads to a variety of the cardiovascular diseases, including the arterial hypertension. A number of studies have demonstrated that blood vessels represent important target for IR, and the endothelium is one of the most vulnerable components of the vascular wall. IR causes an inhibition of nitric oxide (NO)-mediated endothelium-dependent vasodilatation and generation of reactive oxygen (ROS) and nitrogen (RNS) species trigger this process. Read More
Microbiologyopen 2018 Dec 3:e00658. Epub 2018 Dec 3.
Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Innsbruck, Austria.
Stabilization of fractures with internal fixation devices is a common procedure and implant-associated infections are a dreaded complication. The exact pathomechanism is not completely understood; however, microbial colonization of osteosynthesis material is considered a trigger for infection. This study aimed to determine the colonization rate of osteosynthesis implants in patients with no clinical or laboratory signs of infection, using two methods, conventional culture and polymerase chain reaction (PCR) of sonication fluid. Read More
Am J Epidemiol 2018 Dec;187(12):2498-2502
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona.
How influenza A viruses host-jump from animal reservoir species to humans, which can initiate global pandemics, is a central question in pathogen evolution. The zoonotic and spatial origins of the influenza virus associated with the "Spanish flu" pandemic of 1918 have been debated for decades. Outbreaks of respiratory disease in US swine occurred concurrently with disease in humans, raising the possibility that the 1918 virus originated in pigs. Read More
Carcinogenesis 2018 Dec 2. Epub 2018 Dec 2.
Department of Medical Oncology Peter MacCallum Cancer Center, Melbourne VIC, Australia.
It has been historically uncertain if extra centrosomes are a cause or consequence of tumorigenesis. Experiments have recently established that overexpression of polo-like kinase 4 (PLK4) promotes centrosome amplification with consequential promotion of cellular aneuploidy. Furthermore, centrosome amplification drives spontaneous tumorigenesis in mice. Read More
Nucl Med Commun 2018 Nov 29. Epub 2018 Nov 29.
Department of Nuclear Medicine, Sant'Andrea Hospital, La Spezia.
Purpose: Several factors have been identified that predict positive fluorine-18-fluoromethylcholine (F-FCH) PET/CT result in patients with prostate cancer undergoing PET/CT for biochemical failure. Among these factors, prostate-specific antigen (PSA) is the single factor most consistently associated with the prediction of positive F-FCH PET/CT. In this study, we wished to confirm this finding and expand it in a large series of patients. Read More
Spine (Phila Pa 1976) 2018 Dec;43(24):E1454-E1462
Aster MIMS Hospital, Calicut, Kerala, India.
Study Design: A retrospective case series.
Objective: The aim of this study was to report the immunosuppression and secondary bacterial infection after dengue viral infection and the predilection of these infections in the spine. This can trigger further research in to this fact. Read More
Curr Opin Organ Transplant 2018 Nov 30. Epub 2018 Nov 30.
Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, USA.
Purpose Of Review: Regulated cell death (RCD) is likely to play a role in organ rejection but it is unclear how it may be invoked. A well-known trigger of regulated cell death is tumor necrosis factor-alpha (TNF), which activates both caspase-dependent apoptosis and caspase-independent necroptosis. TNF is best known as a pro-inflammatory cytokine because it activates NFκB and MAPK signaling to induce expression of pro-inflammatory genes. Read More
J Back Musculoskelet Rehabil 2018 Nov 23. Epub 2018 Nov 23.
Gaziler Physical Medicine and Rehabilitation Education and Research Hospital, Ankara, Turkey.
Background: Myofascial pain syndrome is a common form of musculoskeletal disorder that originates from a painful site in a muscle or related fascia. There are various non-invasive and invasive treatment methods.
Objective: To investigate the efficacy of myofascial trigger point kinesiotaping with that of local anesthetic injection alone on the degree of pain and quality of life in myofascial pain syndrome. Read More
Plant Signal Behav 2018 Dec 3:1-6. Epub 2018 Dec 3.
a Department of Biological, Chemical and Pharmaceutical Sciences and Technologies , University of Palermo , Palermo , Italy.
Sexually deceptive orchid flowers use visual, tactile and olfactory cues of female insects in order to attract males of one or a few closely related species as pollinators. Ophrys L. is the most species-rich genus of sexually deceptive orchids in the Mediterranean Basin. Read More
ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.
A strategy has been demonstrated to design a biluminescent security ink using Eu(TTA)3Phen (ETP) and fluorescein for protecting the currency and other essential documents viz. passport, bank cheque, certificates against counterfeiting. Biluminescent security ink exhibits strong red and green emission under 367 and 445 nm excitations, respectively. Read More
ACS Appl Mater Interfaces 2018 Dec 3. Epub 2018 Dec 3.
Department of Chemistry and Chemical Biology , Northeastern University , Boston , Massachusetts 02115 , United States.
Color is a signature visual feature in nature; however, the ability to trigger color change in the presence of different environmental stimuli is unique to only a handful of species in the animal kingdom. We exploit the natural color-changing properties of the predominant pigment in arthropods and cephalopods-xanthommatin (Xa)-and describe its utility as a new broad-spectrum electrochromic material. To accomplish this goal, we explored the spectroelectrochemical properties of Xa adsorbed to an indium-doped tin oxide-coated substrate chemically modified with poly(3,4-ethylene dioxythiophene) doped with poly(styrenesulfonate) (PEDOT:PSS). Read More
Macromol Rapid Commun 2018 Dec 3:e1800774. Epub 2018 Dec 3.
Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120, Heidelberg, Germany.
Four tetraphenylethylene (TPE)-based aryleneethynylene polymers with amino or nitro groups are reported. They display strong aggregation-induced emission (AIE). The functional groups trigger acidochromic changes in the emission behavior of these polymers. Read More
J Vet Intern Med 2018 Dec 2. Epub 2018 Dec 2.
Swiss Institute of Equine Medicine, Department of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Background: Currently no methods are available to predict the clinical outcome of individual horses with equine sarcoid (ES) disease.
Objective: To investigate if whole blood microRNA (miRNA) profiles can predict the long-term development of ES tumors.
Animals: Five horses with regression and 5 with progression of ES lesions monitored over 5-7 years and 5 control horses free of ES for at least 5 years. Read More
J Neurooncol 2018 Dec 1. Epub 2018 Dec 1.
Department of Neurosurgery, University Hospital of Münster, Münster, Germany.
Background: There is an increasing interest in local tumor ablative treatment modalities that induce immunogenic cell death and the generation of antitumor immune responses.
Methods: We report six recurrent glioblastoma patients who were treated with intracavitary thermotherapy after coating the resection cavity wall with superparamagnetic iron oxide nanoparticles ("NanoPaste" technique). Patients underwent six 1-h hyperthermia sessions in an alternating magnetic field and, if possible, received concurrent fractionated radiotherapy at a dose of 39. Read More
Environ Sci Pollut Res Int 2018 Dec 1. Epub 2018 Dec 1.
Departamento de Biologia, Universidade de Aveiro, Campus de Santiago, 3810-193, Aveiro, Portugal.
The modern usage of pharmaceutical drugs has led to a progressive increase in their presence and environment concentrations, particularly in the aquatic compartment which is the most common final dumping location for this specific class of chemicals. These substances, due to their chemical and biological properties, can exert mostly uncharacterized toxic effects to non-target aquatic species, given the diverse pathways they activate, and the large number of putative targets in the wild. Among drugs in the environment, paracetamol assumes a leading role, considering its widespread therapeutic use and consequently, environmental presence. Read More
Chem Commun (Camb) 2018 Dec 3. Epub 2018 Dec 3.
Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), 1037 Luoyu road, Wuhan 430074, China.
Inspired by the heme iron-catalyzed radical insertion of dioxygen to the tryptophan indole ring, herein we utilize alkylperoxy radical species as a coupling partner to trigger a peroxycyclization of readily accessible tryptophan derivatives and enable the first synthesis of peroxypyrroloindolenines. A preliminary biological evaluation revealed promising anti-cancer activities (IC50 = 22.00 μM for compound 2a), and revealed that both the indolenine core and the peroxy functionality are responsible for the antiproliferation effect against Hela cell lines. Read More
Plant Direct 2018 Jun 5;2(6). Epub 2018 Jun 5.
Department of Biology and Center for Engineering MechanoBiology, Washington University in Saint Louis, Saint Louis, Missouri.
Mechanosensitive (MS) ion channels provide a universal mechanism for sensing and responding to increased membrane tension. MscS-like (MSL) 10 is a relatively well-studied MS ion channel from that is implicated in cell death signaling. The relationship between the amino acid sequence of MSL10 and its conductance, gating tension, and opening and closing kinetics remains unstudied. Read More
mSystems 2018 Nov-Dec;3(6). Epub 2018 Nov 20.
Leishmaniasis Group, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
The 90-kDa heat shock protein (HSP90) of eukaryotes is a highly abundant and essential chaperone required for the maturation of regulatory and signal proteins. In the protozoan parasite Leishmania donovani, causative agent of the fatal visceral leishmaniasis, HSP90 activity is essential for cell proliferation and survival. Even more importantly, its inhibition causes life cycle progression from the insect stage to the pathogenic, mammalian stage. Read More
Inflamm Intest Dis 2018 Nov 11;3(1):43-51. Epub 2018 Oct 11.
Kantar Health, Paris, France.
Background: Pharmaceutical treatment prescribed according to patient preference for a formulation may have a positive impact on adherence to treatment and consequently on treatment outcomes.
Aim: This study aimed at understanding patient preference for pharmaceutical formulations and attributes that trigger patient preference and physician perception of patient preference.
Methods: Between August and September 2017, gastroenterologists and patients with mild to moderate ulcerative colitis from France, Germany, Spain, and the UK participated in an online survey. Read More
Front Physiol 2018 16;9:1607. Epub 2018 Nov 16.
Biological Engineering, University of California, San Diego, La Jolla, CA, United States.
We demonstrate that erythrocyte deformations, specifically of a type as occur in splenic flow (Zhu et al., 2017), and of the type that promote vesiculation can be caused by simple, yet tailored, oscillatory shear flow. We show that such oscillatory shear flow provides an ideal environment to explore a wide variety of metabolic and biochemical effects that promote erythrocyte vesiculation. Read More
Sci Rep 2018 Nov 30;8(1):17522. Epub 2018 Nov 30.
Department of Neurology, University of California, San Francisco, San Francisco, CA, 94122, USA.
NMDA-type glutamate receptors (NMDAR) trigger superoxide production by neuronal NADPH oxidase-2 (NOX2), which if sustained leads to cell death. This process involves Ca influx through NMDAR channels. By contrast, comparable Ca influx by other routes does not induce NOX2 activation or cell death. Read More
Nat Commun 2018 Nov 30;9(1):5116. Epub 2018 Nov 30.
Princess Margaret Cancer Centre Research Institute, University Health Network, Toronto, M5G2M9, ON, Canada.
Neutrophil extracellular traps (NETs) promote cancer metastasis in preclinical models following massive exogenous inflammatory stimuli. It remains unknown whether cancer hosts under physiologic conditions experience NETosis and consequent metastasis. Here we show that plasma redox imbalance caused by albumin oxidation promotes inflammation-independent NETosis. Read More
Sci Rep 2018 Nov 30;8(1):17486. Epub 2018 Nov 30.
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Germany.
Response inhibition is a key component of executive functioning, but the role of perceptual processes has only recently been focused. Although the interrelation of incoming information and resulting behavioural (motor) effects is well-known to depend on gain control mechanisms, the causal role of sensory gain modulation for response inhibition is elusive. We investigate it using a somatosensory response inhibition (Go/Nogo) task and examine the effects of parietal (somatosensory) cathodal and sham tDCS stimulation on a behavioural and neurophysiological level. Read More
Nat Commun 2018 Nov 30;9(1):5117. Epub 2018 Nov 30.
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, iChEM, University of Science and Technology of China, 230026, Hefei, Anhui, China.
Superchiral light, generated by the interference of two counter-propagating circularly polarized light (CPL) with same frequency, opposite handedness and different intensity, exhibits enhanced dissymmetry in its interaction with chiral molecules, and has the potential for ultrasensitive detection and characterization of chiral molecules. It is anticipated that the enhanced optical dissymmetry in superchiral light (SCL) field may be utilized to promote asymmetric photochemical reactions efficiency. Herein we reported SCL impart greater chiral bias to trigger asymmetric photo-polymerization reaction from initially achiral diacetylene (DA) monomer, and the enhanced optical dissymmetry for whole polydiacetylene (PDA) films could be achieved. Read More