9,755 results match your criteria Trigeminal Neuralgia


Neural activity in trigeminal neuralgia patients with sensory and motor stimulations: A pilot functional MRI study.

Clin Neurol Neurosurg 2022 Jun 18;219:107343. Epub 2022 Jun 18.

Department of Neurosurgery, OSF HealthCare System, OSF Saint Francis Medical Center, Peoria, USA; University of Illinois College of Medicine at Peoria, Peoria, USA.

Objective: Trigeminal neuralgia (TN) is a neuropathic pain syndrome that typically exhibits paroxysmal pain. However, the true mechanism of pain processing is unclear. We aim to evaluate the neural activity changes, before and after radiofrequency rhizotomy, in TN patients using functional MRI (fMRI) with sensory and motor stimulations. Read More

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Percutaneous radiofrequency trigeminal rhizotomy benefits in patients with refractory trigeminal neuralgia.

Medicine (Baltimore) 2022 Jun 24;101(25):e29543. Epub 2022 Jun 24.

Chiayi Chang Gung Memorial Hospital, Pu-Tz, Chia-Yi, Taiwan.

Abstract: A significant number of patients suffers from refractory trigeminal neuralgia (TN) after receiving microvascular decompression (MVD) or other neuro-destructive procedure such as gamma knife radiosurgery (GKRS). This study aims to demonstrate a remediable, reproducible approach to treating refractory pain effectively by percutaneous radiofrequency trigeminal rhizotomy (RF-TR).A total of 392 patients with TN were treated by RF-TR during the past 10 years. Read More

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Olfactory Ensheathing Cells Alleviate Facial Pain in Rats with Trigeminal Neuralgia by Inhibiting the Expression of P2X7 Receptor.

Brain Sci 2022 May 30;12(6). Epub 2022 May 30.

Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China.

Trigeminal neuralgia (TN) is a common facial neuropathic pain that is mainly characterized by spontaneous or induced needling or electric shock pain in the innervation area of the trigeminal nerve. It is also referred to as "the cancer that never dies". The olfactory ensheathing cell (OEC) is a special glial cell in the nervous system that has a strong supportive function in nerve regeneration. Read More

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Low serum uric acid levels are associated with incidence and severity in trigeminal neuralgia.

Neurol Sci 2022 Jun 23. Epub 2022 Jun 23.

Department of Nephrology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People's Republic of China.

Background: Uric acid is a natural antioxidant, and low levels of uric acid have been reported to be a potential risk factor in the development of nervous system diseases. Herein, we investigated whether uric acid levels play a role in trigeminal neuralgia (TN).

Methods: We conducted a cohort study to compare the serum uric acid levels of patients with TN and healthy controls. Read More

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Intermediate nerve neuralgia developed during hemifacial spasm follow-up: illustrative case.

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE22144. Epub 2022 Jun 20.

Department of Neurosurgery, International University of Health and Welfare, School of Medicine, Narita Hospital, Chiba, Japan.

Background: Intermediate nerve neuralgia (INN) is a rare condition believed to be caused by vascular compression, with external auditory canal pain as the chief symptom. The authors reported a rare case of a 78-year-old woman who developed INN during follow-up for hemifacial spasm (HFS).

Observations: The patient had been receiving Botox treatment for right HFS for 20 years when she developed paroxysmal electric shock pain in the right external auditory canal and tinnitus induced by opening her mouth. Read More

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Neuropathic Pain Associated with COVID-19: a Systematic Review of Case Reports.

Curr Pain Headache Rep 2022 Jun 22. Epub 2022 Jun 22.

Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.

Purpose Of Review: Researchers suggests that patients with COVID-19 develop neuropathic pain within weeks or months following infection and that patients with neuropathic pain and COVID-19 sometimes present with deterioration of neurologic complications and pain exacerbation. The objective of this systematic review is to discuss the case-reports having neuropathic pain during and after COVID-19 infection.

Recent Findings: Case reports that has described about patients getting neuropathy or neuropathic pain around the disease either immediately or late post COVID were included. Read More

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Cervical Spinal Cord Stimulation for Trigeminal Neuralgia: a Narrative Review.

Curr Pain Headache Rep 2022 Jun 18. Epub 2022 Jun 18.

Peconic Bay Medical Center/Northwell Health, Riverhead, NY, USA.

Background: Trigeminal neuralgia (TN) is a chronic neuropathic pain condition affecting one or more divisions of the fifth cranial (trigeminal) nerve. TN is defined by recurrent unilateral electric shock-like pain that is abrupt in both onset and termination. The pain is triggered by innocuous sensory stimuli and is classified as either classic TN, related to vascular compression; secondary TN, due to a tumor along the trigeminal nerve or an underlying disease like multiple sclerosis; or idiopathic TN. Read More

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Trigeminal Rhizotomy Using Gyroscopic Radiosurgery: A Case Report.

Cureus 2022 May 12;14(5):e24951. Epub 2022 May 12.

Neurosurgery, Barrow Neurological Institute, Phoenix, USA.

Characterized by intense, episodic lancinating pain within the distribution of the trigeminal nerve, trigeminal neuralgia (TN) is the most common craniofacial pain syndrome. Failure of medical management requires the consideration of interventional procedures. Stereotactic radiosurgery (SRS) is one of the more commonly used surgical options. Read More

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Pharmacotherapeutic management of trigeminal neuropathic pain: an update.

Expert Opin Pharmacother 2022 Jun 23:1-10. Epub 2022 Jun 23.

Paolo Procacci Foundation, Rome, Italy.

Introduction: Guidelines recommend a number of pharmacotherapeutic options used as monotherapy or in combination with others for treating the pain of trigeminal neuropathy.

Areas Covered: The authors examine the pharmacotherapeutic options for treating trigeminal neuralgia and supporting evidence in the literature. Guidelines reported the most effective treatment for trigeminal neuropathy, in particular trigeminal neuralgia, appears to be carbamazepine or oxcabazepine, but side effects can be treatment limiting. Read More

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MRI Findings in Trigeminal Neuralgia without Neurovascular Compression: Implications of Petrous Ridge and Trigeminal Nerve Angles.

Korean J Radiol 2022 May 27. Epub 2022 May 27.

Department of Radiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: To determine the anatomical characteristics of the petrous ridge and trigeminal nerve in trigeminal neuralgia (TN) without neurovascular compression (NVC).

Materials And Methods: From May 2017 to March 2021, 66 patients (49 female and 17 male; mean age ± standard deviation [SD], 56.8 ± 13. Read More

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Complex Neurovascular Syndromes: Is the Compressing Vessel Alone the Culprit?

J Neurosci Rural Pract 2022 Apr 28;13(2):283-289. Epub 2022 Mar 28.

Department of Neuro and Spine Surgery, Neuro World and Suchirayu Hospital, Hubli, Karnataka, India.

 To describe and correlate the clinical, radiological, and intraoperative findings in patients with refractory neurovascular syndromes (NVS) not responding to conventional medical management and to determine the surgical outcome of the microvascular decompression (MVD) procedure. Medical records of 17 patients with NVS (trigeminal neuralgia [TN] = 14 and hemifacial spasm = 3) who underwent surgery for symptom relief from January 2018 to July 2021 with follow-up data (1-36 months) were retrospectively analyzed. Patient demographics (age, sex), clinical features (site, duration of symptoms, distribution), magnetic resonance imaging (MRI) findings, micro-neurosurgical details (type of surgery, obstructive vessel), and postoperative outcome and complications were recorded. Read More

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Successful treatment of vancomycin-resistant enterococcal infection of an external ventricular drain with 2 weeks of intravenous linezolid.

Access Microbiol 2022 29;4(3):000335. Epub 2022 Mar 29.

Department of Medical Microbiology, Queen Elizabeth University Hospital, 1345 Govan Road, Glasgow G51 4TF, UK.

Hydrocephalus is a common condition worldwide, and is frequently managed by diversion of cerebrospinal fluid (CSF), either externally with a drain or internally with a shunt. An external ventricular drain (EVD) can be an essential treatment modality, but is associated with a risk of infection, most commonly caused by species, which can result in meningitis or ventriculitis and a delay in the definitive management of the hydrocephalus. Here, we report the case of a patient who required an EVD to manage post-operative hydrocephalus following a craniotomy and microvascular decompression for trigeminal neuralgia. Read More

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Microanatomy of the central myelin portion and transitional zone of the oculomotor and abducens nerves.

Folia Morphol (Warsz) 2022 Jun 13. Epub 2022 Jun 13.

Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: The microanatomy of the central myelin portion and transitional zone of several cranial nerves including trigeminal, facial, vestibulocochlear, glossopharyngeal, and vagus nerves have been clearly demonstrated to provide information for neurovascular compression syndrome such as trigeminal neuralgia and hemifacial spasm. However, the study of oculomotor and abducens nerve is limited.

Material And Methods: Oculomotor and abducens nerves were harvested with a portion of brainstem and embeded in paraffin. Read More

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A giant foramen of Vesalius: case report.

Anat Cell Biol 2022 Jun 13. Epub 2022 Jun 13.

Department of Neurosurgery, Tulane Center for Clinical Neurosciences, Tulane University School of Medicine, New Orleans, LA, USA.

Anatomical variations identified at the skull base can result in challenges to the clinician. For example, the anatomy of the foramen ovale and its neighboring structures is critical knowledge for the surgeon who performs transcutaneous approaches to the foramen ovale for treating patients with trigeminal neuralgia. One nearby structure that can compound invasive procedures and potentially result in complications is the foramen of Vesalius. Read More

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Trigeminal neuropathy as presenting symptom of craniofacial venous metameric syndrome.

Neurol Sci 2022 Jun 13. Epub 2022 Jun 13.

Neurology Department, Cerrahpaşa Medical Faculty, Istanbul University-Cerrahpaşa, Istanbul, Turkey.

Aims: Trigeminal neuropathy is more likely to suggest neuronal damage and occur due to secondary pathology than trigeminal neuralgia. Evaluation of underlying etiologies are necessary.

Case: A 29-year-old female patient presented with left sided continuous burning pain likened to pins and needles at maxillary distribution for about a year. Read More

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Occipital Nerve Stimulation for Recurrent Trigeminal Neuralgia Without Occipital Pain.

Neuromodulation 2022 Jun 7. Epub 2022 Jun 7.

Fédération Hospitalo-Universitaire INOVPAIN, Centre Hospitalier Universitaire de Nice, Côte d'Azur University, Nice, France; Department of Neurosurgery, Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France.

Objectives: Trigeminal neuralgia (TN) is a severe, debilitating pain condition causing physical and emotional distress. Although the management of TN is well codified with medical and then surgical treatments, 15% to 30% of patients will experience intractable pain. Neuromodulation techniques have been scarcely used for refractory TN, with only small case series and short-term follow-up. Read More

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Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis.

Int J Mol Sci 2022 May 24;23(11). Epub 2022 May 24.

Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan.

Trigeminal neuralgia is unilateral, lancinating, episodic pain that can be provoked by routine activities. Anticonvulsants, such as carbamazepine, are the drugs of choice; however, these possess side-effects. Microvascular decompression is the most effective surgical technique with a higher success rate, although occasionally causes adverse effects. Read More

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Deep Learning Based Real-Time Semantic Segmentation of Cerebral Vessels and Cranial Nerves in Microvascular Decompression Scenes.

Cells 2022 06 2;11(11). Epub 2022 Jun 2.

Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China.

Automatic extraction of cerebral vessels and cranial nerves has important clinical value in the treatment of trigeminal neuralgia (TGN) and hemifacial spasm (HFS). However, because of the great similarity between different cerebral vessels and between different cranial nerves, it is challenging to segment cerebral vessels and cranial nerves in real time on the basis of true-color microvascular decompression (MVD) images. In this paper, we propose a lightweight, fast semantic segmentation Microvascular Decompression Network (MVDNet) for MVD scenarios which achieves a good trade-off between segmentation accuracy and speed. Read More

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Neuralgia and Atypical Facial, Ear, and Head Pain.

Otolaryngol Clin North Am 2022 Jun;55(3):595-606

Caruso Department of Otolaryngology Head & Neck Surgery, University of Southern California, 1537 Norfolk Street, Suite 5800, Los Angeles, CA 90033, USA. Electronic address:

Though there have been considerable strides in the diagnosis and care of orofacial pain disorders, facial neuralgias, and myofascial pain dysfunction syndrome remain incredibly cumbersome for patients and difficult to manage for providers. Cranial neuralgias, myofascial pain syndromes, temporomandibular dysfunction (TMD), dental pain, tumors, neurovascular pain, and psychiatric diseases can all present with similar symptoms. As a result, a patient's quest for the treatment of their orofacial pain often begins on the wrong foot, with a misdiagnosis or unnecessary procedure, which makes it all the more frustrating for them. Read More

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Percutaneous Procedures for Trigeminal Neuralgia.

J Korean Neurosurg Soc 2022 Jun 9. Epub 2022 Jun 9.

Brain Research Institute, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.

Microvascular decompression is the gold standard for the treatment of trigeminal neuralgia (TN). However, percutaneous techniques still play a role in treating patients with TN and offer several important advantages and efficiency in obtaining immediate pain relief, which is also durable in a less invasive and safe manner. Patients' preference for a less invasive method can influence the procedure they will undergo. Read More

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Efficacy of bupivacaine injection after pulsed radiofrequency ablation in the management of trigeminal facial pain: A prospective, randomized, and double-blind study.

Saudi Med J 2022 Jun;43(6):551-558

From the Department of Anesthesia (Hilal), King Fahad General Hospital, and from the Department of Anesthesia and Critical Care (Alyamani, Kaki), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Objectives: To assess the effect of bupivacaine application following pulsed radiofrequency (PRF) ablation on trigeminal facial pain.

Methods: A total of 73 patients with trigeminal facial pain refractory to conservative therapy were randomized into 2 groups. Group I subjects underwent PRF ablation procedure, followed by the injection of 1 ml of bupivacaine. Read More

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Secondary trigeminal neuralgia diagnosed in orofacial pain setting as epidermoid tumor.

Quintessence Int 2022 Jun;53(7):624-630

This case report describes the rare occurrence of an epidermoid tumor compressing the ipsilateral trigeminal nerve resulting in secondary trigeminal neuralgia. MRI is the imaging modality of choice for the diagnosis of secondary trigeminal neuralgia. The epidermoid tumor was discovered by an orofacial pain specialist after reassessing the MRI study, previously reported as normal. Read More

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Trigeminal extracranial thermocoagulation along with patient-controlled analgesia with esketamine for refractory postherpetic neuralgia after herpes zoster ophthalmicus: A case report.

World J Clin Cases 2022 May;10(13):4220-4225

Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University, Jiaxing 314000, Zhejiang Province, China.

Background: Primary trigeminal neuralgia can achieve satisfactory results through clinical treatment and intervention. The pathogenesis of neuralgia caused by varicella-zoster virus infection of the trigeminal nerve is more complex, and it is still difficult to relieve the pain in some patients simply by drug treatment or surgical intervention.

Case Summary: A 66-year-old woman was hospitalized with herpetic neuralgia after herpes zoster ophthalmicus (varicella-zoster virus infects the ophthalmic branch of the trigeminal nerve). Read More

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Acute lymphocytic leukemia in a patient with long-term carbamazepine exposure: Acute lymphoblastic leukemia that develops in a patient who has been using carbamazepine for a long time.

J Oncol Pharm Pract 2022 Jun 3:10781552221105856. Epub 2022 Jun 3.

Department of Hematology, Faculty of Medicine in 52993Selcuk University, Konya, Turkey.

Introduction: Carbamazepine is an antiepileptic drug used in the treatment of epilepsy, trigeminal neuralgia, and bipolar disorder. Hematological effects that may develop with this anticonvulsant; agranulocytosis, thrombocytopenia, leukopenia, aplastic anemia, eosinophilia, or pancytopenia.

Case Report: In this article, we wanted to present a case diagnosed with acute lymphoblastic leukemia after long-term use of carbamazepine because of epilepsy. Read More

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Trigeminal Herpes Zoster Transited to Ipsilateral Occipital Neuralgia.

Neurol Int 2022 May 18;14(2):437-440. Epub 2022 May 18.

Department of Oral Medicine, Nihon University School of Dentistry, Tokyo 101-8310, Japan.

The pain of occipital neuralgia (ON) is thought to be secondary to trauma or injury to the occipital nerve at any point along the course of the nerve. ON may also be caused by an infectious process (herpes zoster) or compression of the nerve. The patient, in this case, presented to our clinic with complaints of occipital pain and rash and swelling of the right lower jaw. Read More

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Clinical outcomes of partial sensory root rhizotomy on patients with recurrence of multiple sclerosing trigeminal neuralgia after percutaneous balloon compression.

Mult Scler Relat Disord 2022 Jul 16;63:103883. Epub 2022 May 16.

Department of Neurosurgery, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan 750002, Ningxia, China. Electronic address:

Objective: To investigate the clinical outcomes of partial sensory root rhizotomy (PSR) on patients with recurrence of multiple sclerosing trigeminal neuralgia(TN-MS) after percutaneous balloon compression (PBC).

Methods: 21 patients with recurrence of TN-MS after PBC were treated with PSR between January 2012 and July 2018. The visual analogue score (VAS) of participants before and after PBC/PSR were observed, and the postoperative recurrence rate of PBC/PSR were recorded, and the postoperative complications were also followed up. Read More

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Central Nervous System Demyelination Following COVID-19 mRNA-Based Vaccination: Two Case Reports and Literature Review.

J Cent Nerv Syst Dis 2022 24;14:11795735221102747. Epub 2022 May 24.

Department of Neurology, Queen Elizabeth Hospital, Kota Kinabalu, Malaysia.

As the world embarks on mass vaccination against SARS-CoV2 to alleviate the spread of this highly contagious novel coronavirus, there are growing anecdotal reports on immune-related neurological complications following immunisation. Similarly, we encountered 2 cases of central nervous system demyelination at our centre with Comirnaty (BNT162b2), a mRNA-based COVID-19 vaccine. Our first patient had typical clinical-radiological manifestations of acute disseminated encephalomyelitis (ADEM) after his COVID-19 vaccination. Read More

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Trigeminal Neuralgia Is a Dementia Risk Factor: A Retrospective Cohort Study.

Int J Environ Res Public Health 2022 05 17;19(10). Epub 2022 May 17.

Department of Psychiatry, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

: Dementia, a worldwide public-health issue, is regarded as a disorder rather than a normal aging process. Trigeminal neuralgia (TN) is a chronic debilitating pain disorder that impairs daily activities. Both are most prevalent in females and in patients older than 50 years. Read More

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Cerebrospinal Fluid in Classical Trigeminal Neuralgia: An Exploratory Study on Candidate Biomarkers.

Biomedicines 2022 Apr 26;10(5). Epub 2022 Apr 26.

Department of Medical Sciences, Section of Neurosurgery, Uppsala University, SE-751 85 Uppsala, Sweden.

Trigeminal neuralgia (TN) is a severe type of facial pain. A neurovascular conflict between cranial nerve V and a nearby vessel is the main pathophysiological mechanism, but additional factors are likely necessary to elicit TN. In this study, the primary aim was to explore differences in protein expression in the cerebrospinal fluid (CSF) of TN patients in relation to controls. Read More

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Global Trends and Hotspots in Trigeminal Neuralgia Research From 2001 to 2021: A Bibliometric Analysis.

Front Neurol 2022 10;13:894006. Epub 2022 May 10.

Department of Neurosurgery, Hangzhou First People's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.

Background: In recent years, there have been an increasing number of studies on trigeminal neuralgia (TN). However, a scientific and comprehensive study of the current situation and trends in the field of TN research is lacking. The purpose of this study is to summarize and visualize the development, research hotspots, and future trends in TN based on a bibliometric approach. Read More

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