8,404 results match your criteria Trigeminal Neuralgia


Trigeminal neuralgia secondary to multiple sclerosis: from the clinical picture to the treatment options.

J Headache Pain 2019 Feb 19;20(1):20. Epub 2019 Feb 19.

Department of Human Neurosciences, Sapienza University, Viale Università 30, 00185, Rome, Italy.

Background: Trigeminal neuralgia is one of the most characteristic and difficult to treat neuropathic pain conditions in patients with multiple sclerosis. The present narrative review addresses the current evidence on diagnostic tests and treatment of trigeminal neuralgia secondary to multiple sclerosis.

Methods: We searched for relevant papers within PubMed, EMBASE and the Cochrane Database of Systematic Reviews, taking into account publications up to December 2018. Read More

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http://dx.doi.org/10.1186/s10194-019-0969-0DOI Listing
February 2019

A meta-analysis of endoscopic microvascular decompression versus microscopic microvascular decompression for the treatment for cranial nerve syndrome caused by vascular compression.

World Neurosurg 2019 Feb 15. Epub 2019 Feb 15.

Departments of Neurosurgery and Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China. Electronic address:

Objective: The aim of this study was to compare the efficacy and safety of endoscopic microvascular decompression (E-MVD) and microscopic microvascular decompression (M-MVD) for the treatment for cranial nerve syndrome caused by vascular compression, including primary trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia.

Methods: A systematic search of the online databases, including PubMed, Embase, Web of Science, Cochrane Central Register of Controlled Trials, China Biology Medicine disc, and China National Knowledge Infrastructure, was performed from January 1966 to March 2018. The language of the included literature was not limited. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.220DOI Listing
February 2019

Effects of long non-coding RNA uc.48+ on pain transmission in trigeminal neuralgia.

Brain Res Bull 2019 Feb 14. Epub 2019 Feb 14.

Department of Physiology, Basic Medical College, Nanchang University, Nanchang, Jiangxi, 330006, PR China; Jiangxi Provincial Key Laboratory of Autonomic Nervous Function and Disease, Nanchang, Jiangxi, 330006, PR China. Electronic address:

Trigeminal neuralgia (TN) is the most common neuropathic pain in the facial area, for which the effective therapy is unavailable. Long non-coding RNA (lncRNA) such as lncRNA uc.48+ is involved in diabetic neuropathic pain and may affect purinergic signaling in ganglia of diabetic rats. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.02.009DOI Listing
February 2019

Locating the foramen ovale by using molar and inter-eminence planes: a guide for percutaneous trigeminal neuralgia procedures.

J Neurosurg 2019 Feb 15:1-7. Epub 2019 Feb 15.

Departments of1Natural Sciences and Mathematics and.

OBJECTIVEThe first attempt to cannulate the foramen ovale is oftentimes unsuccessful and requires subsequent reattempts, thereby increasing the risk of an adverse event and radiation exposure to the patient and surgeon. Failure in cannulation may be attributable to variation in soft-tissue-based landmarks used for needle guidance. Also, the incongruity between guiding marks on the face and bony landmarks visible on fluoroscopic images may also complicate cannulation. Read More

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http://dx.doi.org/10.3171/2018.11.JNS182276DOI Listing
February 2019
4 Reads

The Herpes simplex's reactivation after surgical treatment of Trigeminal Neuralgia. A retrospective cohort study.

World Neurosurg 2019 Feb 13. Epub 2019 Feb 13.

Human Neurosciences Department, Neurosurgery Division "Sapienza" University, AOU Policlinico Umberto I, Rome, Italy.

Background: The Herpes Simplex Virus (HSV) reactivation after surgical procedure for trigeminal neuralgia (TN) has been known and recognized since a long time. To date, only few studies, focused on this complication and at present its real incidence remains unknown. The aim of the present paper is to investigate the real incidence of postoperative Herpes Labialis in a cohort of patients treated alternatively with PBC or MVD to outline potentially significant differences among different treatments. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.226DOI Listing
February 2019
2 Reads

Greater palatine block for V2 trigeminal neuralgia: Case report.

Spec Care Dentist 2019 Feb 15. Epub 2019 Feb 15.

Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Canada.

Aims: This study describes a novel nerve block directed at the maxillary (V2) division of the fifth cranial nerve as treatment for medication-refractory trigeminal neuralgia (TN).

Methods And Results: The authors present three cases of TN treated with V2 nerve block using commonly available local anesthetics injected through the greater palatine foramen. Patients' medications were noted before and after the procedure. Read More

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http://doi.wiley.com/10.1111/scd.12365
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http://dx.doi.org/10.1111/scd.12365DOI Listing
February 2019
1 Read

Primary neurolymphomatosis of the trigeminal nerve.

Br J Neurosurg 2019 Feb 11:1-4. Epub 2019 Feb 11.

a Department of Neurosurgery , Asahikawa Medical University , Hokkaido , Japan.

We report a case of a primary malignant lymphoma of the trigeminal nerve that was associated with facial pain. A 65-year-old man was examined at another hospital for unilateral facial pain. Carbamazepine was prescribed, but his symptoms did not improve. Read More

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http://dx.doi.org/10.1080/02688697.2019.1568391DOI Listing
February 2019
1 Read

Revision Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm: Factors Associated with Surgical Failure.

J Neurol Surg B Skull Base 2019 Feb 29;80(1):31-39. Epub 2018 Jun 29.

Department of Neurological Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, United Sates.

 To investigate risk factors for symptom recurrence in patients requiring a revision microvascular decompression (MVD) for trigeminal neuralgia (TN) or hemifacial spasm (HFS).  Retrospective review of a prospectively maintained database.  Seventeen consecutive patients undergoing revision MVD at our institution between January 1993 and September 2017. Read More

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http://dx.doi.org/10.1055/s-0038-1661348DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365246PMC
February 2019

Efficacy of Neurectomy of Peripheral Branches of the Trigeminal Nerve in Trigeminal Neuralgia: A Critical Review of the Literature.

J Maxillofac Oral Surg 2019 Mar 4;18(1):15-22. Epub 2018 Apr 4.

4Department of Oral and Maxillofacial Surgery, Sri Venkateshwaraa Dental College, Ariyur, Pondicherry, India.

Introduction: Of the many chronic painful conditions, trigeminal neuralgia (TN) affecting the orofacial region needs the particular attention of physicians and surgeons, especially those specialising in the maxillofacial region. Treatment protocols for the management of classic TN include pharmacology and surgical intervention. Oral and maxillofacial surgeons have traditionally employed the peripheral neurectomy in the surgical management of TN. Read More

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http://dx.doi.org/10.1007/s12663-018-1108-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6328817PMC

Effect of Acupuncture on Cognitive Function and Quality of Life in Patients With Idiopathic Trigeminal Neuralgia.

J Nerv Ment Dis 2019 Jan 31. Epub 2019 Jan 31.

Department of Pain Treatment, Tianjin First Central Hospital, Tianjin, China.

To estimate the effect of acupuncture on idiopathic trigeminal neuralgia (ITN), we recruited 116 patients with ITN from December 2016 to April 2018 and further divided into them into two groups: acupuncture intervention group (n = 62) and sham control group (n = 54). Clinical pain, cognitive function, and quality of life (QoL) assessed with the 36-Item Short Form Health Survey (SF-36) were evaluated at the initial time of treatment, at the end of treatment, and 6 weeks after the treatment. Pain intensity, headache, and generalized body pain showed significant decrease both at the end of treatment and after 6 weeks of treatment when compared with initial time. Read More

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http://dx.doi.org/10.1097/NMD.0000000000000937DOI Listing
January 2019

Varying length of central myelin along the trigeminal nerve might contribute to trigeminal neuralgia.

Clin Anat 2019 Feb 5. Epub 2019 Feb 5.

Department of Organ & Tissue Anatomy, Hamamatsu University School of Medicine, Shizuoka, Japan.

Several studies have suggested that vascular compression of more distal portions of the trigeminal nerve (Vth cranial nerve: VN) may cause trigeminal neuralgia (TN). However, neurosurgeons performing microvascular decompression intraoperatively cannot identify which type of myelin is being compressed by blood vessels. The aim of this study was to clarify the histological anatomy of central and peripheral myelin in the human VN. Read More

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http://dx.doi.org/10.1002/ca.23348DOI Listing
February 2019
1 Read

Sex-dependent posterior fossa anatomical differences in trigeminal neuralgia patients with and without neurovascular compression: a volumetric MRI age- and sex-matched case-control study.

J Neurosurg 2019 Feb 1:1-8. Epub 2019 Feb 1.

Departments of1Neurological Surgery and.

OBJECTIVEThe pathophysiology of trigeminal neuralgia (TN) in patients without neurovascular compression (NVC) is not completely understood. The objective of this retrospective study was to evaluate the hypothesis that TN patients without NVC differ from TN patient with NVC with respect to brain anatomy and demographic characteristics.METHODSSix anatomical brain measurements from high-resolution brain MR images were tabulated; anterior-posterior (AP) prepontine cistern length, cerebellopontine angle (CPA) cistern volume, nerve-to-nerve distance, symptomatic nerve length, pons volume, and posterior fossa volume were assessed on OsiriX. Read More

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http://dx.doi.org/10.3171/2018.9.JNS181768DOI Listing
February 2019

A history of the Jannetta procedure.

J Neurosurg 2019 Feb 1:1-8. Epub 2019 Feb 1.

2Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.

Peter Jannetta was a neurosurgery resident when he proposed the neurovascular compression theory. He built upon the astute observations of Dandy, Gardner, and others who, in the era before the operating microscope, had successfully ventured into the posterior fossa. In 1965, Jannetta performed cranial nerve microdissections for dental students and identified the trigeminal portio intermedia. Read More

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http://dx.doi.org/10.3171/2018.10.JNS181983DOI Listing
February 2019

The possible prognostic role of magnetic resonance imaging findings in patients with trigeminal neuralgia and multiple sclerosis submitted to percutaneous balloon compression. Report of our series and literature review.

World Neurosurg 2019 Feb 1. Epub 2019 Feb 1.

Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University, Rome.

Objective: We studied the correlation of magnetic resonance imaging (MRI) findings with the prognosis of multiple sclerosis (MS)-related trigeminal neuralgia (TN) patients submitted to percutaneous balloon compression (PBC). No articles have previously been reported on this topic. We also performed a literature review of the pertinent studies. Read More

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http://dx.doi.org/10.1016/j.wneu.2019.01.134DOI Listing
February 2019
1 Read

Efficacy and Safety of Repeated Percutaneous Radiofrequency Thermocoagulation for Recurrent Trigeminal Neuralgia.

Front Neurol 2018 18;9:1189. Epub 2019 Jan 18.

Department of Pain Management, The Second Hospital of Hebei Medical University, Shijiazhuang, China.

Percutaneous radiofrequency thermocoagulation (PRT) is used to treat trigeminal neuralgia (TN) with a satisfactory pain relief but a high recurrence rate. To explore the efficacy and safety of repeated PRT for recurrent TN as compared to patients who received the first PRT. Between January 2013 to May 2013, 31 patients with recurrent TN who have been treated with PRT previously were recruited and underwent repeated PRT (group A), and compared with 41 TN patients received the first initial PRT (group B). Read More

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http://dx.doi.org/10.3389/fneur.2018.01189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6345700PMC
January 2019

Acupuncture for primary trigeminal neuralgia: A systematic review and PRISMA-compliant meta-analysis.

Complement Ther Clin Pract 2019 Feb 24;34:254-267. Epub 2018 Dec 24.

The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China; Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China. Electronic address:

Background And Purpose: Acupuncture is increasingly used by patients with primary trigeminal neuralgia (PTN). We aimed to evaluate the efficacy and safety of acupuncture for PTN.

Methods: Seven databases were searched. Read More

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http://dx.doi.org/10.1016/j.ctcp.2018.12.013DOI Listing
February 2019

Nonmigraine Headache and Facial Pain.

Med Clin North Am 2019 Mar 20;103(2):235-250. Epub 2018 Dec 20.

Department of Neurology, Brigham and Women's Hospital, John R. Graham Headache Center, Brigham and Women's Faulkner Hospital, Harvard Medical School, 1153 Centre Street, Suite 4H, Boston, MA 02130, USA. Electronic address:

The vast majority of headache patients encountered in the outpatient general medicine setting will be diagnosed with a primary headache disorder, mostly migraine or tension-type headache. Other less common primary headaches and secondary headaches, related to or caused by another condition, are the topic of this article. Nonmigraine primary headaches include trigeminal autonomic cephalalgias, primarily cluster headache; facial pain, primarily trigeminal neuralgia; and miscellaneous headache syndromes, such as hemicrania continua and new daily persistent headache. Read More

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http://dx.doi.org/10.1016/j.mcna.2018.10.007DOI Listing
March 2019
6 Reads

Comparison of the Neuropathic Pain Symptoms and Psychosocial Impacts of Trigeminal Neuralgia and Painful Posttraumatic Trigeminal Neuropathy.

J Oral Facial Pain Headache 2019 Winter;33(1):77-88

Aims: To compare the impacts of trigeminal neuralgia (TN) and painful posttraumatic trigeminal neuropathy (PPTTN) on psychologic function and health-related quality of life (HRQoL) using a comprehensive quantitative assessment.

Methods: This was a comparative cross-sectional study. A total of 97 patients diagnosed with PPTTN and 40 patients diagnosed with TN who sought treatment at an orofacial pain clinic completed standardized self-report measures of pain intensity, neuropathic symptoms, pain self-efficacy, mood, and indicators of general and oral HRQoL. Read More

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http://dx.doi.org/10.11607/ofph.2157DOI Listing
February 2019

A case of ultrasound diagnosis of supraorbital neuralgia.

Muscle Nerve 2019 Jan 31. Epub 2019 Jan 31.

Institute of Neurology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Catholic University of Sacred Heart, Rome, Italy.

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http://dx.doi.org/10.1002/mus.26440DOI Listing
January 2019

Therapeutic efficacy and safety of radiofrequency ablation for the treatment of trigeminal neuralgia: a systematic review and meta-analysis.

J Pain Res 2019 18;12:423-441. Epub 2019 Jan 18.

Department of Otorhinolaryngology, Affiliated Hospital of Nantong University, Nantong 226001, People's Republic of China,

Objective: The objective of this study was to summarize the effectiveness and safety of trigeminal neuralgia (TN) treatment via different radiofrequency approaches such as continuous radiofrequency (CRF), pulsed radiofrequency (PRF), and combined CRF and pulsed radiofrequency (CCPRF) treatments, thus providing high-quality clinical evidence for TN treatment.

Methods: A series of databases were searched for relevant articles published between January 1998 and April 2018. The modified Jadad scale was referred to evaluate the methodological quality of the included studies. Read More

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http://dx.doi.org/10.2147/JPR.S176960DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6342144PMC
January 2019
5 Reads

One hundred eleven Percutaneous Balloon Compressions for Trigeminal Neuralgia in a Cohort of 66 Patients with Multiple Sclerosis.

Oper Neurosurg (Hagerstown) 2019 Jan 23. Epub 2019 Jan 23.

Department of Neurosurgery, Umeå University, Umeå, Sweden.

Background: Trigeminal neuralgia associated with multiple sclerosis (MS-TN) is comparatively rare and larger series of percutaneous balloon compression (PBC) in such cases are few in the literature.

Objective: To evaluate the results after PBC for MS-TN with regards to therapeutic effect, side effects, and complications.

Methods: One hundred eleven procedures with PBC performed in 66 cases of MS-TN were analyzed. Read More

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http://dx.doi.org/10.1093/ons/opy402DOI Listing
January 2019

A novel scoring system as a preoperative predictor for pain-free survival after microsurgery for trigeminal neuralgia.

J Neurosurg 2019 Jan 25:1-8. Epub 2019 Jan 25.

Departments of1Neurological Surgery and.

OBJECTIVEPain relief following microvascular decompression (MVD) for trigeminal neuralgia (TN) may be related to pain type, degree of neurovascular conflict, arterial compression, and location of compression. The objective of this study was to construct a predictive pain-free scoring system based on clinical and radiographic factors that can be used to preoperatively prognosticate long-term outcomes for TN patients following surgical intervention (MVD or internal neurolysis [IN]). It was hypothesized that contributing factors would include pain type, presence of an artery or vein, neurovascular conflict severity, and compression location (root entry zone). Read More

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http://dx.doi.org/10.3171/2018.9.JNS181208DOI Listing
January 2019
2 Reads

Arachnoid membranes around the cisternal segment of the trigeminal nerve: a cadaveric anatomical study and intraoperative observations during minimally-invasive microvascular decompression surgery.

World Neurosurg 2019 Jan 23. Epub 2019 Jan 23.

Laboratory for Applied and Clinical Anatomy, Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, Hungary.

Objective: The minimally invasive microsurgical decompression for trigeminal neuralgia (MVD) is technically a more challenging operation compared to the standard retrosigmoidal approach. Endoscopic assistance could help to widen the microscope´s field of view during MVD. An extended view around the cisternal segment of the trigeminal nerve can be achieved only with the targeted dissection of the arachnoid membranes. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193015
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http://dx.doi.org/10.1016/j.wneu.2019.01.060DOI Listing
January 2019
4 Reads

Acupuncture treatment on idiopathic trigeminal neuralgia: A systematic review protocol.

Medicine (Baltimore) 2019 Jan;98(4):e14239

Department of Acupuncture and Moxibustion, Tongde Hospital of Zhejiang Province.

Introduction: The objective of this systematic review protocol is to provide the methods for evaluating the effectiveness and safety of acupuncture on the treatment of idiopathic trigeminal neuralgia (ITN).

Methods And Analysis: We will search randomized controlled trials (RCTs) on this subject in 8 electronic databases and they are Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), the Wan-Fang Database, and Chinese Scientific Journal Database (VIP database). Other relevant literatures will be manually searched as a complement. Read More

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http://dx.doi.org/10.1097/MD.0000000000014239DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6358347PMC
January 2019

[Experimental study of a new animal model with trigeminal neuralgia produced by administration of talc to peripheral infraobital nerve in rats].

Shanghai Kou Qiang Yi Xue 2018 Oct;27(5):472-476

Department of Oral and Maxillofacial Surgery, Key Lab of Oral Clinical Medicine, Affiliated Hospital of Qingdao University, College of Stomatology,Qingdao University. Qingdao 266003, Shandong Province, China.

Purpose: To establish a new animal model of trigeminal neuralgia(TN) produced by administration of talc to peripheral infraobital nerve in rats.

Methods: Thirty male Wistar rats were randomly divided into 2 groups. Talcum powder (30%,0. Read More

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October 2018
1 Read

Factors predicting successful outcomes for percutaneous radiofrequency thermocoagulation in patients with idiopathic trigeminal neuralgia: implications for surgical decision making.

Pain Pract 2019 Jan 24. Epub 2019 Jan 24.

Clinical Neuroscience Institute, Yuquan Hospital, Medical Center, Tsinghua University, Beijing, 100040, P.R. China.

Objectives: This study aimed to identify specific factors predicting successful outcomes after percutaneous radiofrequency thermocoagulation (RFT) for Idiopathic Trigeminal neuralgia (ITN) and risk factors that were associated with inferior outcomes.

Methods: We retrospectively reviewed our cohort of 1624 patients who underwent RFT for trigeminal neuralgia between January 2000 and December 2017. Demographic and clinical data including age, gender, disease duration, affected side, baseline pain score, pain distribution, history of previous surgical intervention and pain characteristics were collected and evaluated for their association with outcome using univariate and multivariate logistic regression analysis. Read More

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http://dx.doi.org/10.1111/papr.12769DOI Listing
January 2019
1 Read

Comparing Microvascular Decompression with Gamma Knife Radiosurgery for Trigeminal Neuralgia A Cost-effectiveness Analysis.

World Neurosurg 2019 Jan 17. Epub 2019 Jan 17.

Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213.

Background And Objective: Both Microvascular decompression (MVD) and Gamma knife radiosurgery (GKRS) are time tested treatment modalities for Trigeminal Neuralgia. There is little evidence in the literature studying these modalities head to head in a cost-effectiveness comparison.

Objective: To evaluate the cost-effectiveness of MVD compared with GKRS for treating patients with Trigeminal Neuralgia. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18788750193008
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http://dx.doi.org/10.1016/j.wneu.2018.12.204DOI Listing
January 2019
3 Reads

Mutational screening of the SH3TC2 gene in Greek patients with suspected demyelinating recessive Charcot-Marie-Tooth disease reveals a varied and unusual phenotypic spectrum.

J Peripher Nerv Syst 2019 Jan 17. Epub 2019 Jan 17.

Neurogenetics Unit, 1st Department of Neurology, Eginition Hospital, Medical School National and Kapodistrian University of Athens, Athens, Greece.

Charcot-Marie-Tooth disease type 4 C (CMT4C) is an autosomal recessive form of demyelinating peripheral neuropathy caused by mutations in SH3TC2, characterized by early onset, spine deformities, and cranial nerve involvement. We screened SH3TC2 in 50 unrelated Greek patients with suspected demyelinating Charcot-Marie-Tooth disease and pedigree compatible with recessive inheritance. All patients had been previously screened for PMP22, GJB1, and MPZ mutations. Read More

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http://dx.doi.org/10.1111/jns.12305DOI Listing
January 2019
1 Read

Topical Ambroxol 20% for the Treatment of Classical Trigeminal Neuralgia - A New Option? Initial Clinical Case Observations.

Headache 2019 Jan 17. Epub 2019 Jan 17.

Migraine and Headache Clinic, Königstein, Germany.

Background: Trigeminal neuralgia is difficult to treat and shows upregulation of sodium channels. The expectorant ambroxol acts as a strong local anesthetic, about 40 times stronger than lidocaine. It preferentially inhibits the channel subtype Na 1. Read More

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http://dx.doi.org/10.1111/head.13475DOI Listing
January 2019

Gamma Knife Radiosurgery for Trigeminal Neuralgia Caused by a Cavernous Malformation: Case Report and Literature Review.

Stereotact Funct Neurosurg 2018 16;96(6):412-415. Epub 2019 Jan 16.

Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Objective: Trigeminal neuralgia (TN) related to a brainstem cavernous malformation (CM) is a rare entity. We present the first radiosurgical management of a patient with TN secondary to a CM.

Clinical Presentation: An 80-year-old female presented with a 33-year history of progressively severe TN refractory to medications. Read More

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http://dx.doi.org/10.1159/000495476DOI Listing
January 2019
1 Read

Effects of microvascular decompression plus longitudinal nerve sectioning on recurrent trigeminal neuralgia and investigations of postoperative recurrence causes.

Turk Neurosurg 2018 Jul 2. Epub 2018 Jul 2.

Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine.

Aim: Recurrent trigeminal neuralgia (RTN) is a challenge for neurosurgeons. It is challenging to develop an appropriate treatment method for patients who respond poorly to initial therapies. This study aimed to investigate the causes of RTN and to evaluate the efficacy of microvascular decompression (MVD) plus longitudinal nerve sectioning (LNS) or LNS only for RTN patients who have received multiple procedures. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.23513-18.1DOI Listing
July 2018
1 Read

Evaluation of the Retrogasserian Opioid Application in the Treatment of Idiopathic Trigeminal Neuralgia.

Turk Neurosurg 2018 Jun 21. Epub 2018 Jun 21.

Farabi Hospital.

Aim: The aim of this study is to evaluate the clinical outcomes of the retrogasserian opioid application in patients with type 1 trigeminal neuralgia.

Material And Methods: A total of 37 patients (12 male, 25 female; average age 56.2 ± 5. Read More

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http://dx.doi.org/10.5137/1019-5149.JTN.22604-18.2DOI Listing

Pain-free survival after vagoglossopharyngeal complex sectioning with or without microvascular decompression in glossopharyngeal neuralgia.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

OBJECTIVEGlossopharyngeal neuralgia (GN) is a rare pain condition in which patients experience paroxysmal, lancinating throat pain. Multiple surgical approaches have been used to treat this condition, including microvascular decompression (MVD), and sectioning of cranial nerve (CN) IX and the upper rootlets of CN X, or a combination of the two. The aim of this study was to examine the long-term quality of life and pain-free survival after MVD and sectioning of the CN X/IX complex. Read More

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http://dx.doi.org/10.3171/2018.8.JNS18239DOI Listing
January 2019
4 Reads

Patterns of opioid use in patients with trigeminal neuralgia undergoing neurosurgery.

J Neurosurg 2019 Jan 11:1-7. Epub 2019 Jan 11.

OBJECTIVEFirst-line treatment for trigeminal neuralgia (TN) is pharmacological management using antiepileptic drugs (AEDs), e.g., carbamazepine (CBZ) and oxcarbazepine (OCBZ). Read More

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http://dx.doi.org/10.3171/2018.8.JNS1893DOI Listing
January 2019
6 Reads

Transcranial direct current stimulation (tDCS) and trigeminal pain: A preclinical study.

Oral Dis 2019 Jan 12. Epub 2019 Jan 12.

Pharmacology of Pain and Neuromodulation Laboratory: Preclinical Researches, Department of Pharmacology, Institute of Basic Health Sciences (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.

Objective: Our objective was to evaluate the Transcranial direct current stimulation (tDCS) effect on facial allodynia induced by chronic constriction of the infraorbital nerve (CCI-ION) and on the brainstem levels of TNF-α, NGF, IL-10, and serum LDH in rats.

Methods: Rats were exposed to the CCI-ION model. Facial allodynia was assessed by von Frey filaments test at baseline, 3, 7, 10, and 14 days postsurgery and 24 hr and 7 days after the bimodal tDCS sessions for 20 min/day/8 days. Read More

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http://dx.doi.org/10.1111/odi.13038DOI Listing
January 2019
1 Read
2.427 Impact Factor

Sphenopalatine Neuralgia: An Independent Neuralgia Entity. Pooled Analysis of a Case Series and Literature Review.

Headache 2019 Jan 11. Epub 2019 Jan 11.

Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Background: Structural damage or demyelization of the sphenopalatine ganglion may cause sphenopalatine neuralgia (SN). The current International Classification of Headache Disorders, third edition (ICHD-3) regards SN as a phenotype of cluster headache. Whether SN is an independent neuralgia entity has been debated for years. Read More

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http://dx.doi.org/10.1111/head.13469DOI Listing
January 2019
1 Read

Burst or Conventional Peripheral Nerve Field Stimulation for Treatment of Neuropathic Facial Pain.

Neuromodulation 2019 Jan 10. Epub 2019 Jan 10.

Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Background: Trigeminal Neuropathic Pain (TNP) is a chronic facial pain syndrome caused by a lesion or disease affecting one or more branches of the trigeminal nerve. It may, for example, result from accidental injury to a branch of the trigeminal nerve by trauma or during surgery; it may also be idiopathic. TNP is typically constant, in contrast to most cases of the commoner trigeminal neuralgia. Read More

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http://doi.wiley.com/10.1111/ner.12922
Publisher Site
http://dx.doi.org/10.1111/ner.12922DOI Listing
January 2019
2 Reads

A correlative analysis between inflammatory cytokines and trigeminal neuralgia or hemifacial spasm.

Neurol Res 2019 Jan 5:1-6. Epub 2019 Jan 5.

a Department of Neurosurgery , XinHua Hospital (The Cranial Nerve Disease Center of Shanghai), Shanghai JiaoTong University School of Medicine , Shanghai , China.

Background: It is necessary to understand the mechanism of trigeminal neuralgia (TN) and hemifacial spasm (HFS) in order to seek for an effective noninvasive remedy. As previous studies implied that inflammatory cytokines induced by demyelination following the nerve injury may be the initiated factor causing neuropathic pain, we attempt to analyze the correlation between cytokines and these hyperactive cranial nerve disorders.

Method: The consecutive patients whose diagnosis were confirmed by microvascular decompression surgery as primary TN or HFS caused by vascular compression and healthy volunteers between March and May 2018 in XinHua Hospital Shanghai JiaoTong University School of Medicine were recruited. Read More

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https://www.tandfonline.com/doi/full/10.1080/01616412.2018.1
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http://dx.doi.org/10.1080/01616412.2018.1564188DOI Listing
January 2019
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The Craniovertebral Junction in Rheumatoid Arthritis: State of the Art.

Acta Neurochir Suppl 2019 ;125:79-86

Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, Neurosurgical Clinic, University of Palermo, Palermo, Italy.

Rheumatoid arthritis (RA) is a chronic inflammatory disorder, characterized by polyarticular inflammation causing progressive joint damage and disability. The mechanisms underlying its pathogenesis involve activation of innate and adaptive immunity, microvascular endothelial cell activation, and inflammatory infiltration of lymphocytes and monocytes into the synovium. Spinal involvement in RA is not typical; when it occurs, the main radiological features are (1) atlantoaxial subluxation (AAS), which is the most typical form of cervical spine involvement; (2) cranial settling-also known as basilar impression, atlantoaxial impaction or superior migration of the odontoid-which is the most severe form of associated spinal instability; and (3) subaxial subluxation. Read More

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http://dx.doi.org/10.1007/978-3-319-62515-7_12DOI Listing
January 2019
3 Reads

On the Surgical Implications of Peritrigeminal Perforating Vessels in Microvascular Decompression.

Oper Neurosurg (Hagerstown) 2018 Dec 31. Epub 2018 Dec 31.

Department of Neurological Surgery, Weill Cornell Medicine/New York Presbyterian Hospital, New York, New York.

Background: Perforating branches arising from the superior cerebellar artery (SCA) or anterior inferior cerebellar artery (AICA) that pierces the brainstem within 5 mm of the trigeminal root may limit offending vessel transposition during microvascular decompression for trigeminal neuralgia.

Objective: To investigate the microsurgical anatomy of peritrigeminal perforators and evaluate their effect on the mobility of the SCA and AICA. Additionally, we propose strategies for mitigating the potential complications caused by the presence of short peritrigeminal perforators. Read More

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http://dx.doi.org/10.1093/ons/opy325DOI Listing
December 2018

Milestones in stereotactic radiosurgery for the central nervous system.

J Clin Neurosci 2019 Jan 26;59:12-19. Epub 2018 Oct 26.

Department of Neurosurgery, Stanford University School of Medicine, Stanford Health Care and Stanford Children's Health, Stanford Neuroscience Health Center, 213 Quarry Road, Palo Alto, CA 94304-5979, United States.

Introduction: Since Lars Leksell developed the first stereotactic radiosurgery (SRS) device in 1951, there has been growth in the technologies available and clinical indications for SRS. This expansion has been reflected in the medical literature, which is built upon key articles and institutions that have significantly impacted SRS applications. Our aim was to identify these prominent works and provide an educational tool for training and further inquiry. Read More

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http://dx.doi.org/10.1016/j.jocn.2018.09.029DOI Listing
January 2019
1 Read

Evaluation of Clinical and Histologic Effects of High-Dose Radiosurgery on Rat Dorsal Root Ganglion.

World Neurosurg 2018 Dec 27. Epub 2018 Dec 27.

Department of Neurosurgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. Electronic address:

Background: Stereotactic radiosurgery (SRS) is an effective technique to create lesions of the trigeminal nerve to treat refractory trigeminal neuralgia. In the lumbar spine, the dorsal root ganglion (DRG) contains the body of the sensory neurons responsible for pain sensitivity. Neuromodulation of the DRG might therefore improve chronic peripheral pain. Read More

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http://dx.doi.org/10.1016/j.wneu.2018.12.082DOI Listing
December 2018

[3D printing navigation template-guided percutaneous radiofrequency thermocoagulation for V2 trigeminal neuralgia treatment].

Hua Xi Kou Qiang Yi Xue Za Zhi 2018 12;36(6):662-666

Dept. of Oral and Maxillofacial Surgery, Zhengzhou Stomatological Hospital, Zhengzhou 450000, China.

Objective: This paper aimed to evaluate the effectiveness of the 3D printing puncture navigation template-guided percutaneous radiofrequency thermocoagulation for V2 trigeminal neuralgia treatment.

Methods: A total of 52 patients with V2 trigeminal neuralgia were treated with radiofrequency thermocoagulation. A total of 32 patients were treated under the guidance of the 3D printing puncture navigation template (guide plate group), while 20 patients underwent puncture via pterygopalatine fossa routinely (routine treatment group). Read More

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http://dx.doi.org/10.7518/hxkq.2018.06.015DOI Listing
December 2018

Challenges recruiting to a proof-of-concept pharmaceutical trial for a rare disease: the trigeminal neuralgia experience.

Trials 2018 Dec 27;19(1):704. Epub 2018 Dec 27.

Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy.

Background: This study aimed to describe recruitment challenges encountered during a phase IIa study of vixotrigine, a state and use-dependent Nav1.7 channel blocker, in individuals with trigeminal neuralgia.

Methods: This was an international, multicenter, placebo-controlled, randomized withdrawal study that included a 7-day run-in period, a 21-day open-label phase, and a 28-day double-blind phase in which patients (planned n = 30) were randomized to vixotrigine or placebo. Read More

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https://trialsjournal.biomedcentral.com/articles/10.1186/s13
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http://dx.doi.org/10.1186/s13063-018-3045-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6307274PMC
December 2018
5 Reads

The IASP classification of chronic pain for ICD-11: chronic neuropathic pain.

Pain 2019 Jan;160(1):53-59

Department of Neurophysiology, CBTM, Medical Faculty Mannheim of Heidelberg University, Mannheim, Germany.

The upcoming 11th revision of the International Statistical Classification of Diseases and Related Health Problems (ICD) of the World Health Organization (WHO) offers a unique opportunity to improve the representation of painful disorders. For this purpose, the International Association for the Study of Pain (IASP) has convened an interdisciplinary task force of pain specialists. Here, we present the case for a reclassification of nervous system lesions or diseases associated with persistent or recurrent pain for ≥3 months. Read More

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http://Insights.ovid.com/crossref?an=00006396-201901000-0000
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http://dx.doi.org/10.1097/j.pain.0000000000001365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310153PMC
January 2019
12 Reads
5.213 Impact Factor

Executive Dysfunction After Fourth-Ventricle Epidermoid Cyst Resection.

Cogn Behav Neurol 2018 Dec;31(4):207-213

Neuropsychology Research Unit, The University of Queensland, Brisbane, Australia.

Intracranial epidermoid cysts are rare, comprising 0.2% to 1.8% of all primary intracranial expanding lesions, of which <5% occur within the fourth ventricle. Read More

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http://dx.doi.org/10.1097/WNN.0000000000000175DOI Listing
December 2018
6 Reads

Radiosurgery for multiple sclerosis-related trigeminal neuralgia: retrospective review of long-term outcomes.

J Neurosurg 2018 Nov 1:1-8. Epub 2018 Nov 1.

OBJECTIVEThe objective of this study was to assess long-term outcomes of facial pain and numbness after radiosurgery for multiple sclerosis (MS)-related trigeminal neuralgia (MS-TN).METHODSThe authors conducted a retrospective review of their Gamma Knife radiosurgeries (GKRSs) to identify all patients treated for MS-TN (1998-2014) with at least 3 years of follow-up. Treatment and clinical data were obtained via chart review and mailed or telephone surveys. Read More

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http://dx.doi.org/10.3171/2018.5.JNS173194DOI Listing
November 2018
3 Reads

Endoscopic versus open microvascular decompression for trigeminal neuralgia: a systematic review and comparative meta-analysis.

J Neurosurg 2018 Dec 1:1-9. Epub 2018 Dec 1.

1Division of Neurosurgery, Department of Surgery; and.

OBJECTIVEMicrovascular decompression (MVD) is commonly used in the treatment of trigeminal neuralgia (TN) with positive clinical outcomes. Fully endoscopic MVD (E-MVD) has been proposed as an effective minimally invasive alternative, but a comparative review of the two approaches has not been conducted. The authors performed a meta-analysis of studies, comparing patient outcome rates and complications for the open versus the endoscopic technique. Read More

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http://dx.doi.org/10.3171/2018.6.JNS172690DOI Listing
December 2018