9,315 results match your criteria Trigeminal Neuralgia


Trigeminal neuralgia: a practical guide.

Pract Neurol 2021 Jun 9. Epub 2021 Jun 9.

Headache and Facial Pain Group, UCL Queen Square Institute of Neurology, London, UK

Trigeminal neuralgia (TN) is a highly disabling disorder characterised by very severe, brief and electric shock like recurrent episodes of facial pain. New diagnostic criteria, which subclassify TN on the basis of presence of trigeminal neurovascular conflict or an underlying neurological disorder, should be used as they allow better characterisation of patients and help in decision-making regarding medical and surgical treatments. MR, including high-resolution trigeminal sequences, should be performed as part of the diagnostic work-up. Read More

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The journeys of patients with trigeminal neuralgia on a background of multiple sclerosis.

Pain Manag 2021 Jun 9. Epub 2021 Jun 9.

Facial Pain Unit Royal National Ear Nose & Throat & Eastman Dental Hospitals, UCLH NHS Foundation Trust, 47-49 Huntley Street, London, WC1E 6DG, UK.

Multiple sclerosis (MS) is well recognized as a secondary cause for trigeminal neuralgia (TN). In this case series, we detail the management of all the patients with TN and MS (pwTNMS) presenting to a specialist unit. A prospective patient database was used to extract key clinical data on pharmacological, psychometric and surgical management of 20 pwTNMS. Read More

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Is trigeminal neuralgia the only definitive diagnosis for pain in a tooth extraction site?

BMC Oral Health 2021 Jun 7;21(1):291. Epub 2021 Jun 7.

Honorary Consultant in Orofacial Pain Department, International Campus Dental School, Tehran University of Medical Sciences, Tehran, Iran.

Knowing the International Classification of Orofacial Pain helps pain specialists to differentiate types of orofacial pain. It is important to select the best treatment or intervention for the patients based on the diagnosis. As part of our study, we reviewed the article published in BMC Oral Health, titled "Clinical characteristics and associated factors of trigeminal neuralgia: Experience from Addis Ababa, Ethiopia" by Ayele et al. Read More

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Application of Augmented Reality in Percutaneous Procedures-Rhizotomy of the Gasserian Ganglion.

Oper Neurosurg (Hagerstown) 2021 Jun 7. Epub 2021 Jun 7.

Department of Stereotactic and Functional Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Background: Percutaneous rhizotomy of the Gasserian ganglion for trigeminal neuralgia is an effective therapeutic procedure. Yet, landmark-guided cannulation of the foramen ovale is manually challenging and difficult to learn.

Objective: To overcome these limitations, we assessed the feasibility and accuracy of an augmented reality (AR)-guided puncture of the foramen ovale. Read More

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Frameless navigation-guided percutaneous rhizotomy of the trigeminal nerve: an appraisal of the literature.

Neurosurg Rev 2021 Jun 5. Epub 2021 Jun 5.

Neurosurgery Department, University Hospital Dr. Josep Trueta, Girona, Girona, Spain.

Percutaneous rhizotomy is a cornerstone of trigeminal neuralgia treatment. The procedure is classically performed under intermittent fluoroscopic guidance. While frameless navigation has been advanced to overcome potential difficulties and risks of the technique, literature on the subject is limited, and a gap between actual use and published series is likely. Read More

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Regional brain morphology predicts pain relief in trigeminal neuralgia.

Neuroimage Clin 2021 May 25;31:102706. Epub 2021 May 25.

Division of Brain, Imaging & Behaviour, Krembil Brain Institute, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Department of Surgery, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada; Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada. Electronic address:

Background: Trigeminal neuralgia, a severe chronic neuropathic pain disorder, is widely believed to be amenable to surgical treatments. Nearly 20% of patients, however, do not have adequate pain relief after surgery. Objective tools for personalized pre-treatment prognostication of pain relief following surgical interventions can minimize unnecessary surgeries and thus are of substantial benefit for patients and clinicians. Read More

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Acute and Chronic Pain from Facial Skin and Oral Mucosa: Unique Neurobiology and Challenging Treatment.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Health Science Center at San Antonio, Programs in Integrated Biomedical Sciences, Department of Oral & Maxillofacial Surgery, School of Dentistry, Translational Sciences, Biomedical Engineering and Radiological Sciences, University of Texas, San Antonio, TX 78229, USA.

The oral cavity is a portal into the digestive system, which exhibits unique sensory properties. Like facial skin, the oral mucosa needs to be exquisitely sensitive and selective, in order to detect harmful toxins versus edible food. Chemosensation and somatosensation by multiple receptors, including transient receptor potential channels, are well-developed to meet these needs. Read More

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N58A Exerts Analgesic Effect on Trigeminal Neuralgia by Regulating the MAPK Pathway and Tetrodotoxin-Resistant Sodium Channel.

Toxins (Basel) 2021 May 17;13(5). Epub 2021 May 17.

School of Life Sciences and Biopharmaceutical Science, Shenyang Pharmaceutical University, Shenyang 110016, China.

The primary studies have shown that scorpion analgesic peptide N58A has a significant effect on voltage-gated sodium channels (VGSCs) and plays an important role in neuropathic pain. The purpose of this study was to investigate the analgesic effect of N58A on trigeminal neuralgia (TN) and its possible mechanism. The results showed that N58A could significantly increase the threshold of mechanical pain and thermal pain and inhibit the spontaneous asymmetric scratching behavior of rats. Read More

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Assessment of Growth Factors, Cytokines, and Cellular Markers in Saliva of Patients with Trigeminal Neuralgia.

Molecules 2021 May 17;26(10). Epub 2021 May 17.

Department of Oral and Maxillo Facial Sciences, Sapienza University of Rome, 00185 Rome, Italy.

We proposed to perform a comparative analysis of growth factors, cytokines, and chemokine receptors on the salivary cells in the saliva obtained from trigeminal neuralgia (TN) and normal subjects. Saliva was collected from TN and healthy subjects. Salivary cells were isolated by centrifugation. Read More

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Retrosigmoid microvascular decompression as a treatment for trigeminal neuralgia in a patient with osteogenesis imperfecta.

Br J Neurosurg 2021 May 31:1-3. Epub 2021 May 31.

Department of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

Individuals with osteogenesis imperfecta develop pathologic bone due to genetic defects in collagen synthesis. These patients are prone to skull base abnormalities with resultant lower cranial nerve deficits, most common of which is trigeminal neuralgia. Typically, such patients are managed medically, and surgical options are not well explored for those patients, who become refractory to medication management. Read More

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Microvascular decompression for trigeminal neuralgia: A retrospective analysis of long-term outcomes and prognostic factors.

Neurologia 2021 May 25. Epub 2021 May 25.

Neurosurgery Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Introduction: Microvascular decompression is considered to be the most effective and only etiological surgical treatment for classical trigeminal neuralgia, relieving the neurovascular compression found in up to 95% of cases. This study aims to report the long-term outcomes and to identify prognostic factors in a series of patients with trigeminal neuralgia treated by microvascular decompression.

Methods: A retrospective observational study of 152 consecutive patients operated by microvascular decompression with at least six months of follow-up. Read More

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Cranial Neuralgias.

Authors:
Carrie Robertson

Continuum (Minneap Minn) 2021 06;27(3):665-685

Purpose Of Review: This article discusses the differential diagnosis, evaluation, and management of trigeminal neuralgia and reviews other neuralgias of the head and neck, including those that contribute to neuralgic ear pain.

Recent Findings: Most cases of trigeminal neuralgia are related to vascular compression, a demyelinating plaque, or a compressive mass affecting the trigeminal nerve. However, recent studies have shown that up to 11% of patients have a family history of trigeminal neuralgia, suggesting that some patients may have a genetic predisposition to demyelination or nerve hyperexcitability. Read More

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Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model.

J Headache Pain 2021 May 27;22(1):47. Epub 2021 May 27.

Department of Neuroscience, College of Medicine, Chungbuk National University, Cheongju, South Korea.

Background: Preceding studies have reported the association of chronic neuropathic orofacial pain with altered ongoing function in the ventrolateral periaqueductal gray (vlPAG). However, its role in trigeminal neuralgia (TN) lacks attention. We here reported the aspect that vlPAG neurons play in TN nociceptive processing by employing excitatory neuron-specific optogenetic approaches. Read More

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Intra-Fraction Motion Management for Radiosurgical Treatments of Trigeminal Neuralgia: Clinical Experience, Imaging Frequency, and Motion Analysis.

Cureus 2021 Apr 21;13(4):e14616. Epub 2021 Apr 21.

Radiation Oncology, David Geffen School of Medicine at University of California, Los Angeles (UCLA), Los Angeles, USA.

Purpose The aim of this study is to evaluate the patient positioning and intra-fraction motion management performance of an image-guidance protocol established for radiosurgical treatments of trigeminal neuralgia patients. Specifically, it also aims to analyze patient motion data for the evaluation of current motion tolerance levels and imaging frequency utilized for repositioning patients. Methods A linear accelerator equipped with ExacTrac is used for patient positioning with stereoscopic imaging and treatments. Read More

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Case report of unusual cause of trigeminal neuralgia: Trigeminal neuralgia secondary to enlarged suprameatal tubercle.

Ann Med Surg (Lond) 2021 Jun 15;66:102308. Epub 2021 Apr 15.

Department of Neurosurgery, Braathen Center, Cleveland Clinic Florida, Weston, FL, USA.

Background: Classic trigeminal neuralgia (TN) is caused by vessels compressing the trigeminal nerve root entry zone. The cause is usually impingement of the superior cerebellar artery, anterior inferior cerebellar artery, or a vein. Other rare causes have been reported including aneurysmal compression, skull base tumors, and vascular malformations. Read More

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Percutaneous radiofrequency treatment of the gasserian ganglion for trigeminal neuralgia complicated by trochlear nerve palsy: a case report.

Reg Anesth Pain Med 2021 May 26. Epub 2021 May 26.

Department of Anesthesiology and Pain Medicine, Amsterdam UMC location AMC, Amsterdam, The Netherlands.

Background: Trigeminal neuralgia (TN) has the highest incidence of disorders causing facial pain. TN is provoked by benign stimuli, like shaving, leading to severe, short-lasting pain. Patients are initially treated using antiepileptic drugs; however, multiple invasive options are available when conservative treatment proves insufficient. Read More

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[A comparative analysis of clinical efficiency of laser and radiofrequency denervation in patients with primary trigeminal neuralgia].

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(4):38-43

Marat Ospanov West Kazakhstan Medical University, Aktobe, Republic of Kazakhstan.

Objective: To compare the clinical efficacy of laser and radiofrequency denervation in patients with primary trigeminal neuralgia.

Material And Methods: The study included 50 patients with primary trigeminal neuralgia who were operated on by laser (group I, =25) or radiofrequency denervation (group II, =25) in the period from 2018 to 2019. To assess the clinical efficacy, we analyzed the dynamics of the pain syndrome level according to the scale of facial pain and the quality of life according to the Short Form Medical Outcomes Study (SF-36), as well as patient satisfaction with the operation according to the Macnab scale, the presence of postoperative surgical complications and adverse effects of anesthesia. Read More

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[Pain in multiple sclerosis and neuromyelitis optica spectrum disorders].

Schmerz 2021 Jun 25;35(3):211-222. Epub 2021 May 25.

Institut für Klinische Neuroimmunologie, LMU Klinikum, Marchioninistr. 15, 81377, München, Deutschland.

Multiple sclerosis and neuromyelitis optica spectrum disorders are autoimmune inflammatory diseases of the central nervous system, which can lead to a multitude of neurological complaints and pain syndromes. Pain may be an acute symptom during disease exacerbation as well as a chronic symptom, whereby the latter sometimes substantially reduces the quality of life. The etiology of pain is very heterogeneous but the rapid differential diagnostic classification is decisive in order to be able to initiate a differentiated treatment strategy. Read More

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Prognostic nomogram for percutaneous balloon compression in the treatment of trigeminal neuralgia.

Neurosurg Rev 2021 May 24. Epub 2021 May 24.

Department of Orthopedic, Taizhou First People's Hospital, Wenzhou Medical University, Taizhou, 318020, Zhejiang Province, China.

Because of its convenience and safety, percutaneous balloon compression (PBC) has become a more popular remedy for trigeminal neuralgia (TN) recently. The objective of this study was to establish a nomogram that can be used to preoperatively prognosticate the likelihood of pain-free based on preoperative disease characteristics. Clinical data were collected from those TN cases who had undergone PBC during the period of 2015 and 2020 in Qingdao Municipal Hospital. Read More

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Secondary hemicrania continua-tic syndrome associated with fungal sphenoiditis: A case report.

Clin Case Rep 2021 May 19;9(5):e04297. Epub 2021 May 19.

Department of Neurology The 940th Hospital of Chinese PLA Lanzhou China.

The coexistence of hemicrania-continua and trigeminal neuralgia is called HC-tic syndrome. We describe a case of an elderly man who suffered both types of headache related to fungal sphenoiditis. This is the first case to be reported, to the best of our knowledge. Read More

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Pain quality of thermal grill illusion is similar to that of central neuropathic pain rather than peripheral neuropathic pain.

Scand J Pain 2021 May 21. Epub 2021 May 21.

Graduate School of Health Science, Kio University, Nara, Japan.

Objectives: Application of spatially interlaced innocuous warm and cool stimuli to the skin elicits illusory pain, known as the thermal grill illusion (TGI). This study aimed to discriminate the underlying mechanisms of central and peripheral neuropathic pain focusing on pain quality, which is considered to indicate the underlying mechanism(s) of pain. We compared pain qualities in central and peripheral neuropathic pain with reference to pain qualities of TGI-induced pain. Read More

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CT-guided radiofrequency treatment of trigeminal neuralgia at different temperatures through foramen rotundus.

Am J Transl Res 2021 15;13(4):3102-3110. Epub 2021 Apr 15.

Department of Pain Management, Shanghai Pudong Hospital, Fudan University Pudong Medical Center Shanghai, China.

Objective: To compare the efficacy and safety of CT-guided radiofrequency therapy in the treatment of trigeminal neuralgia (TN) through foramen rotundus at different temperatures.

Methods: A total of 60 patients with TN in our hospital were selected and randomly divided into the control group and the observation group, with 30 cases in each group. CT or MRI was routinely performed before the operation to exclude intracranial space-occupying lesions. Read More

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Cross Cultural Adaptation and Validation of Italian Version of the Leeds Assessment of Neuropathic Symptoms and Signs Scale and Pain DETECT Questionnaire for the Distinction between Nociceptive and Neuropathic Pain.

Pain Res Manag 2021 28;2021:6623651. Epub 2021 Apr 28.

Department of Medical and Surgical Specialties and Dentistry, University of Campania "Luigi Vanvitelli", Naples, Italy.

Objective: This study aimed to validate Italian versions of Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale and Pain DETECT questionnaire (PD-Q) and evaluate the ability of these questionnaires to discriminate between nociceptive and neuropathic pain.

Design: Multicenter prospective validation cohort study. One hundred patients were included with a diagnosis formulated by a specialist in outpatient settings (50 affected by knee osteoarthritis as nociceptive pain and 50 affected by trigeminal or postherpetic neuralgia as neuropathic pain). Read More

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Comparison of Two Different Pulsed Radiofrequency Modes for Prevention of Postherpetic Neuralgia in Elderly Patients with Acute/Subacute Trigeminal Herpes Zoster.

Neuromodulation 2021 May 18. Epub 2021 May 18.

Department of Pain Medicine, the First Affiliated Hospital to China Medical University, Shenyang, China.

Objective: Trigeminal postherpetic neuralgia (PHN) is often refractory to treatment. Pulsed radiofrequency (PRF) neuromodulation can help in preventing PHN after herpes zoster. This study aimed to compare the efficacy and safety of two different PRF modes on gasserian ganglion neuromodulation in elderly patients with acute/subacute trigeminal herpes zoster. Read More

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Role of Greater Occipital Nerve Block in Headache Disorders: A Narrative Review.

Neurol India 2021 Mar-Apr;69(Supplement):S228-S256

Department of Neurology, GB Pant Institute of Post Graduate Medical Education and Research, New Delhi, India.

Background: The proximity of sensory neurons in the upper cervical spinal cord to the trigeminal nucleus caudalis (TNC) neurons and the convergence of sensory input to TNC neurons from both cervical and trigeminal fibers underscore the rationale of using greater occipital nerve block (GON-block) for acute and preventive treatment in various headache disorders.

Objective: The aim of this study was to critically review the existing literature regarding the safety and efficacy of GON-block in various headache disorders.

Methods: We searched the eligible studies in English by searching in PubMed till December 31, 2020 for randomized controlled trials (RCTs), observational studies, open-label studies, case series, and case reports on the efficacy and the safety of GON-block for the treatment of headache disorders using the keywords "greater occipital nerve block", "headache" and "treatment". Read More

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Occipital Neuralgia and Its Management: An Overview.

Neurol India 2021 Mar-Apr;69(Supplement):S213-S218

Department of Diagnostic Sciences Rutgers School of Dental Medicine, Newark, NJ, USA.

Background: Greater and lesser occipital neuralgias are primary neuralgias that are relatively uncommon, where the pain is felt in the distribution of these nerves.

Objective: This review paper was intended to describe the features and management of occipital neuralgia in the context of a challenging case.

Material And Methods: We looked at succinct literature from the past 30 years. Read More

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Microvascular Decompression for Trigeminal Neuralgia: Experience of a Tertiary Care Center in India and a Brief Review of Literature.

Neurol India 2021 Mar-Apr;69(Supplement):S206-S212

Department of Anesthesia, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, India.

Background: Trigeminal neuralgia (TN) is a devastating condition causing significant patient discomfort and morbidity hampering quality of life. Of the many treatment options available, microvascular decompression (MVD) of the trigeminal nerve is widely performed. However, the procedure is not risk-free. Read More

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Medical Management of Trigeminal Neuralgia.

Neurol India 2021 Mar-Apr;69(Supplement):S199-S205

Associate Consultant Neurologist , Bombay Hospital Institute of Medical Sciences, New Marine Lines, Mumbai, Maharashtra, India.

Background: Trigeminal neuralgia (TN) is a painful condition, often leading to poor quality of life.

Objective: The aim of this review was to discuss the various treatment modalities for the medical management of TN.

Materials And Methods: We reviewed the available literature on TN in clinical databases including PubMed, Google Scholar, and the Cochrane Database of Systematic Reviews, with a specific focus on the pharmacological treatment and newer drugs under development for the treatment of TN. Read More

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Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice.

J Headache Pain 2021 May 17;22(1):38. Epub 2021 May 17.

Institute of Pain Medicine and Special Environmental Medicine, Nantong University, Nantong, 226019, China.

Objectives: In this study, we investigated the possible analgesic effects of Botulinum toxin type A (BoNT/A) on trigeminal neuralgia (TN). A modified TN mouse model was established by chronic constriction injury of the distal infraorbital nerve (dIoN-CCI) in mice, and the possible roles of microglia toll-like receptor 2 (TLR2) and neuroinflammation was investigated.

Methods: Male C57BL/6 mice were divided into 3 groups, including sham group, vehicle-treated TN group and BoNT/A-treated TN group. Read More

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Trigeminal neuralgia and genetics: A systematic review.

Mol Pain 2021 Jan-Dec;17:17448069211016139

Department of Neurosurgery, Oslo University Hospital-Rikshospitalet, Oslo, Norway.

Trigeminal neuralgia (TN) is a severe facial pain disease of unknown cause and unclear genetic background. To examine the existing knowledge about genetics in TN, we performed a systematic study asking about the prevalence of familial trigeminal neuralgia, and which genes that have been identified in human TN studies and in animal models of trigeminal pain. MedLine, Embase, Cochrane Library and Web of Science were searched from inception to January 2021. Read More

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