27,330 results match your criteria Trigeminal Nerve


PHEV infection: A promising model of betacoronavirus-associated neurological and olfactory dysfunction.

PLoS Pathog 2022 Jun 27;18(6):e1010667. Epub 2022 Jun 27.

State Key Laboratory for Zoonotic Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China.

Porcine hemagglutinating encephalomyelitis virus (PHEV) is a highly neurotropic coronavirus belonging to the genus Betacoronavirus. Similar to pathogenic coronaviruses to which humans are susceptible, such as SARS-CoV-2, PHEV is transmitted primarily through respiratory droplets and close contact, entering the central nervous system (CNS) from the peripheral nerves at the site of initial infection. However, the neuroinvasion route of PHEV are poorly understood. Read More

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Herpes Zoster Ophthalmicus Complicated by Unilateral Ptosis and Abducens Nerve Palsy: A Case Report.

Cureus 2022 May 25;14(5):e25311. Epub 2022 May 25.

Ophthalmology, Eye Centers of South Florida, Miami, USA.

Herpes zoster ophthalmicus (HZO) is a viral condition that presents as a painful vesicular rash in the trigeminal nerve dermatome. In some cases, self-limiting extraocular muscle palsies may occur several weeks after the onset of HZO and last for weeks to months. A 71-year-old man developed a debilitating binocular horizontal diplopia and ptosis about four weeks after the onset of HZO symptoms. Read More

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CT-Guided Thermocoagulation of the Pterygopalatine Ganglion for Refractory Trigeminal Autonomic Cephalalgia.

Pain Ther 2022 Jun 24. Epub 2022 Jun 24.

Department of Anesthesiology and Pain Medicine, The Affiliated Hospital of Jiaxing University, No. 1882 Zhong Huan South Road, Jiaxing, 314000, Zhejiang, China.

Introduction: Trigeminal autonomic cephalalgia (TAC) is a type of one-sided cerebral painful headache, with attacks regularly accompanied by autonomic responses, such as tearing, runny nose, panic, nausea and vomiting on the affected side. Currently, the most common treatment strategies are drugs, nerve grafts and surgery. Clinical understanding of TACs is limited. Read More

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Migraine treatment with external concurrent occipital and trigeminal neurostimulation-A randomized controlled trial.

Headache 2022 Jun 24. Epub 2022 Jun 24.

Tel-Aviv University Sackler School of Medicine, Tel-Aviv, Israel.

Objective: To evaluate the efficacy and safety of concurrent non-invasive stimulation of occipital and trigeminal nerves in acute treatment of migraine with or without aura.

Background: Non-invasive neuromodulation devices stimulating a single peripheral nerve or anatomic distribution are routinely used by patients with migraine refractory to the first-line drugs or those who opt out of pharmaceutical treatment. Concurrent occipital and trigeminal stimulation was described in an invasive setting, and its safety cost outweighed its efficacy gain. Read More

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Assessment of Smell and Taste Disturbances among COVID-19 Convalescent Patients: A Cross-Sectional Study in Armenia.

J Clin Med 2022 Jun 9;11(12). Epub 2022 Jun 9.

Neuroscience Laboratory, COBRAIN Center, Yerevan State Medical University after Mkhitar Heratsi, Yerevan 0025, Armenia.

Background And Objectives: Neurological manifestations of Coronavirus Disease 2019 (COVID-19) such as olfactory and gustatory disturbance have been reported among convalescent COVID-19 patients. However, scientific data on the prevalence of smell and taste disturbance are lacking. Therefore, we present findings on the degree of smell and taste disturbances among the Armenian population. Read More

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Olfactory Ensheathing Cells Alleviate Facial Pain in Rats with Trigeminal Neuralgia by Inhibiting the Expression of P2X7 Receptor.

Brain Sci 2022 May 30;12(6). Epub 2022 May 30.

Department of Anatomy, Basic Medical School, Nanchang University, Nanchang 330006, China.

Trigeminal neuralgia (TN) is a common facial neuropathic pain that is mainly characterized by spontaneous or induced needling or electric shock pain in the innervation area of the trigeminal nerve. It is also referred to as "the cancer that never dies". The olfactory ensheathing cell (OEC) is a special glial cell in the nervous system that has a strong supportive function in nerve regeneration. Read More

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Intermediate nerve neuralgia developed during hemifacial spasm follow-up: illustrative case.

J Neurosurg Case Lessons 2022 Jun 20;3(25):CASE22144. Epub 2022 Jun 20.

Department of Neurosurgery, International University of Health and Welfare, School of Medicine, Narita Hospital, Chiba, Japan.

Background: Intermediate nerve neuralgia (INN) is a rare condition believed to be caused by vascular compression, with external auditory canal pain as the chief symptom. The authors reported a rare case of a 78-year-old woman who developed INN during follow-up for hemifacial spasm (HFS).

Observations: The patient had been receiving Botox treatment for right HFS for 20 years when she developed paroxysmal electric shock pain in the right external auditory canal and tinnitus induced by opening her mouth. Read More

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A Distinctive Histological Form of Squamous Cell Carcinoma With Perineural Invasion.

Cureus 2022 May 18;14(5):e25111. Epub 2022 May 18.

Dermatology, Eastern Virginia Medical School, Norfolk, USA.

A modest proportion of individuals diagnosed with squamous cell carcinoma (SCC) display perineural invasion (PNI), the neoplastic invasion of one or more nerves. It is associated with a marked increase in mortality in patients with SCC and is oftentimes only diagnosed after a significant invasion occurs. An 84-year-old male, otherwise in good health, presented to us with a fast-growing, 3-cm nodule on his right malar region associated with paresthesia and radiating pain. Read More

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Inferior Alveolar Nerve Lateralization Surgery for Implant Installation in Atrophic Posterior Mandible With Accessory Mental Foramen: A Challenge for the Usual Technique.

J Craniofac Surg 2022 May;33(3):e255-e257

Department of Oral and Maxillofacial Surgery, Hospital Regional de Osasco SUS, Osasco, Brazil.

Abstract: Implantology allows edentulous patients to smile and chew with confidence. However, the atrophy at posterior region of the mandible is still a challenge due the presence of the inferior alveolar nerve (iAN). The options of restoration with oral implants in this area with great atrophies are few and hazardous. Read More

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Recombinant Human Nerve Growth Factor for Pediatric Neurotrophic Keratopathy.

Eye Contact Lens 2022 Jul 3;48(7):303-305. Epub 2022 Jun 3.

Department of Ophthalmology (D.N., S.S.M.F.), University of California Los Angeles, Los Angeles, CA; and Department of Ophthalmology (D.N.), Banphaeo General Hospital, Samut Sakhon, Thailand.

Abstract: A 4-year-old boy presented with right neurotrophic corneal ulcer, lagophthalmos, and facial palsy 8 months after neurosurgery for synchronous brain tumors. Initial treatment with topical antibiotics, topical corticosteroids, lubrication, and lateral tarsorrhaphy successfully treated the corneal epithelial defect; however, the cornea continued to demonstrate diffuse epitheliopathy and a dense stromal opacity and remained insensate on Cochet-Bonnet esthesiometry. After a course of topical cenegermin, central corneal sensation normalized, and the corneal epitheliopathy was markedly improved. Read More

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EFFICACY OF 4% ARTICAINE BUCCAL INFILTRATION VERSUS INFERIOR ALVEOLAR NERVE BLOCK FOR MANDIBULAR MOLARS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS.

J Evid Based Dent Pract 2022 06 6;22(2):101712. Epub 2022 Mar 6.

Faculty of Dental Medicine and Oral Health Sciences, McGill University, Montreal, QC, Canada. Electronic address:

Objectives: To compare the anesthetic efficacy of buccal infiltration (BI) using 4% articaine vs 4% articaine or 2% lidocaine inferior alveolar nerve block (IANB) for mandibular molars with symptomatic irreversible pulpitis.

Methods: PubMed, Cochrane, Web of Science, Scopus, and ClinicalTrials.gov were searched using MESH terms and specific keywords. Read More

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Cervical Spinal Cord Stimulation for Trigeminal Neuralgia: a Narrative Review.

Curr Pain Headache Rep 2022 Jun 18. Epub 2022 Jun 18.

Peconic Bay Medical Center/Northwell Health, Riverhead, NY, USA.

Background: Trigeminal neuralgia (TN) is a chronic neuropathic pain condition affecting one or more divisions of the fifth cranial (trigeminal) nerve. TN is defined by recurrent unilateral electric shock-like pain that is abrupt in both onset and termination. The pain is triggered by innocuous sensory stimuli and is classified as either classic TN, related to vascular compression; secondary TN, due to a tumor along the trigeminal nerve or an underlying disease like multiple sclerosis; or idiopathic TN. Read More

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Sensory-motor response elicited by first time intraoral administered ethanol after trigeminal neuropathic injury.

Alcohol 2022 Jun 14. Epub 2022 Jun 14.

Sección de neurobiología de las sensaciones orales. Laboratorio de Investigación odontológica, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México Sección de Neurobiología de las sensaciones orales, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autónoma de México.San Sebastián Xhala, San Sebastián Xhala, 54714 Cuautitlán Izcalli, México. Electronic address:

Recent findings have shown a relationship between alcohol use disorders (AUD) and chronic pain. Preclinical models have demonstrated that chronic pain, including trigeminal nerve injury, increases ethanol consumption throughout extended administration periods. Nevertheless, it remains unclear whether chronic pain induces a greater susceptibility to developing AUD by altering motor control consumption regardless of the symptomatology of neuropathic pain and if sex influences this susceptibility. Read More

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Genome sequence and experimental infection of calves with bovine gammaherpesvirus 4 (BoHV-4).

Arch Virol 2022 Aug 16;167(8):1659-1668. Epub 2022 Jun 16.

Department of Veterinary and Biomedical Sciences, South Dakota State University, Box 2175 North Campus Drive, Brookings, SD, 57007, USA.

Bovine gammaherpesvirus 4 (BoHV-4) is ubiquitous in cattle worldwide, and it has been detected in animals exhibiting broad clinical presentations. The virus has been detected in the United States since the 1970s; however, its clinical relevance remains unknown. Here, we determined the complete genome sequences of two contemporary BoHV-4 isolates obtained from respiratory (SD16-38) or reproductive (SD16-49) tract specimens and assessed clinical, virological, and pathological outcomes upon intranasal (IN) inoculation of calves with the respiratory BoHV-4 isolate SD16-38. Read More

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Zebrafish Erc1b mediates motor innervation and organization of craniofacial muscles in control of jaw movement.

Dev Dyn 2022 Jun 16. Epub 2022 Jun 16.

Neuroscience Graduate Program, Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA.

Background: Movement of the lower jaw, a common behavior observed among vertebrates, is required for eating and processing food. This movement is controlled by signals sent from the trigeminal motor nerve through neuromuscular junctions (NMJs) to the masticatory muscles. Dysfunctional jaw movements contribute to craniomandibular disorders, yet the pathophysiology of these disorders is not well understood, as limited studies have been conducted on the molecular mechanisms of jaw movement. Read More

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Neuroinflammation: A Distal Consequence of Periodontitis.

J Dent Res 2022 Jun 16:220345221102084. Epub 2022 Jun 16.

Department of Molecular Pathobiology, New York University College of Dentistry, New York, NY, USA.

Periodontitis, a chronic, inflammatory disease, induces systemic inflammation and contributes to the development of neurodegenerative diseases. The precise etiology of the most common neurodegenerative disorders, such as sporadic Alzheimer's, Parkinson's diseases and multiple sclerosis (AD, PD, and MS, respectively), remains to be revealed. Chronic neuroinflammation is a well-recognized component of these disorders, and evidence suggests that systemic inflammation is a possible stimulus for neuroinflammation development. Read More

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Trigeminal Rhizotomy Using Gyroscopic Radiosurgery: A Case Report.

Cureus 2022 May 12;14(5):e24951. Epub 2022 May 12.

Neurosurgery, Barrow Neurological Institute, Phoenix, USA.

Characterized by intense, episodic lancinating pain within the distribution of the trigeminal nerve, trigeminal neuralgia (TN) is the most common craniofacial pain syndrome. Failure of medical management requires the consideration of interventional procedures. Stereotactic radiosurgery (SRS) is one of the more commonly used surgical options. Read More

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Intranasal Varenicline: Review of a Novel Formulation for the Treatment of Dry Eye Disease.

J Pharm Pract 2022 Jun 15:8971900221108725. Epub 2022 Jun 15.

Pharmacy Practice, 4289South College School of Pharmacy, Knoxville, TN, USA.

To examine the literature pertaining to safety and efficacy of intranasal (IN) varenicline for the treatment of dry eye disease (DED). A literature search of PubMed was performed (1985 to January 2022) using the following search terms: varenicline, OC-01, intranasal, and dry eye. Additional data were acquired from references of identified articles, prescribing information, government databases, and manufacturer website. Read More

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Unknown Etiology for Ataxia and Vertigo After Trigeminal Nerve Block: A Case Report.

A A Pract 2022 Jun 14;16(6):e01598. Epub 2022 Jun 14.

Pain Management Unit, National Hospital of Sri Lanka, Columbo, Sri Lanka.

Acute transient vertigo, ataxia, and hypertension after trigeminal nerve block via a coronoid approach with alcohol have been reported previously. We report a similar complication after the same block with nerve stimulator guidance with bupivacaine without alcohol. Stimulation of the vestibular canal by the needle, or disturbance to its blood supply, presence of an abnormal anatomical connection of the mandibular nerve and vestibular system or spasm of cerebellar arteries from the stimulating needle are possible causations rather than the drug used, whether it is alcohol or bupivacaine. Read More

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Bridging neuroradiology and neuroanatomy: NOWBRAIN-a repository with sequences of correlated and labeled planar-surface neuroimages.

Neuroradiol J 2022 Jun 14:19714009221108674. Epub 2022 Jun 14.

Founder and Chairman, Nowinski Brain Foundation, Warsaw West County, Poland.

: Integrating neuroradiology with neuroanatomy is essential in medical neuroeducation and neuroimage interpretation. To bridge 2D neuroradiology and 3D neuroanatomy, spatially correlated pairs of labeled images were employed, planar radiologic, and planar-surface combined. : The method employs a 3D fully parcellated and labeled brain atlas extended to the head and neck with about 3000 3D components to create planar radiologic and surface neuroanatomic images. Read More

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MRI Findings in Trigeminal Neuralgia without Neurovascular Compression: Implications of Petrous Ridge and Trigeminal Nerve Angles.

Korean J Radiol 2022 May 27. Epub 2022 May 27.

Department of Radiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Objective: To determine the anatomical characteristics of the petrous ridge and trigeminal nerve in trigeminal neuralgia (TN) without neurovascular compression (NVC).

Materials And Methods: From May 2017 to March 2021, 66 patients (49 female and 17 male; mean age ± standard deviation [SD], 56.8 ± 13. Read More

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Microanatomy of the central myelin portion and transitional zone of the oculomotor and abducens nerves.

Folia Morphol (Warsz) 2022 Jun 13. Epub 2022 Jun 13.

Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: The microanatomy of the central myelin portion and transitional zone of several cranial nerves including trigeminal, facial, vestibulocochlear, glossopharyngeal, and vagus nerves have been clearly demonstrated to provide information for neurovascular compression syndrome such as trigeminal neuralgia and hemifacial spasm. However, the study of oculomotor and abducens nerve is limited.

Material And Methods: Oculomotor and abducens nerves were harvested with a portion of brainstem and embeded in paraffin. Read More

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Occipital Nerve Stimulation for Recurrent Trigeminal Neuralgia Without Occipital Pain.

Neuromodulation 2022 Jun 7. Epub 2022 Jun 7.

Fédération Hospitalo-Universitaire INOVPAIN, Centre Hospitalier Universitaire de Nice, Côte d'Azur University, Nice, France; Department of Neurosurgery, Centre Hospitalier Universitaire de Nice, Université Côte d'Azur, Nice, France.

Objectives: Trigeminal neuralgia (TN) is a severe, debilitating pain condition causing physical and emotional distress. Although the management of TN is well codified with medical and then surgical treatments, 15% to 30% of patients will experience intractable pain. Neuromodulation techniques have been scarcely used for refractory TN, with only small case series and short-term follow-up. Read More

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Facial Nerve Function After Microsurgical Resection in Vestibular Schwannoma Under Neurophysiological Monitoring.

Front Neurol 2022 24;13:850326. Epub 2022 May 24.

Department of Neurosurgery, University Hospital Leipzig, Leipzig, Germany.

Background: The use of intraoperative neurophysiological monitoring, including direct nerve stimulation (especially the facial nerve), acoustic evoked potentials (AEP) and somatosensory evoked potentials (SSEP), is a helpful tool in the microsurgery of vestibular schwannoma to prevent nerve injury. Patient characteristics and intraoperative and postoperative variables might also influence the postoperative facial nerve function. The study was performed to investigate these variables and the intraoperative neurophysiological monitoring values. Read More

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Analgesic Effect of Tranilast in an Animal Model of Neuropathic Pain and Its Role in the Regulation of Tetrahydrobiopterin Synthesis.

Int J Mol Sci 2022 May 24;23(11). Epub 2022 May 24.

Department of Stomatognathic Function and Occlusal Reconstruction, Graduate School of Biomedical Sciences, Tokushima University, Tokushima 770-8504, Japan.

Trigeminal neuralgia is unilateral, lancinating, episodic pain that can be provoked by routine activities. Anticonvulsants, such as carbamazepine, are the drugs of choice; however, these possess side-effects. Microvascular decompression is the most effective surgical technique with a higher success rate, although occasionally causes adverse effects. Read More

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Neuralgia and Atypical Facial, Ear, and Head Pain.

Otolaryngol Clin North Am 2022 Jun;55(3):595-606

Caruso Department of Otolaryngology Head & Neck Surgery, University of Southern California, 1537 Norfolk Street, Suite 5800, Los Angeles, CA 90033, USA. Electronic address:

Though there have been considerable strides in the diagnosis and care of orofacial pain disorders, facial neuralgias, and myofascial pain dysfunction syndrome remain incredibly cumbersome for patients and difficult to manage for providers. Cranial neuralgias, myofascial pain syndromes, temporomandibular dysfunction (TMD), dental pain, tumors, neurovascular pain, and psychiatric diseases can all present with similar symptoms. As a result, a patient's quest for the treatment of their orofacial pain often begins on the wrong foot, with a misdiagnosis or unnecessary procedure, which makes it all the more frustrating for them. Read More

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Release of Endocannabinoids into the Cerebrospinal Fluid during the Induction of the Trigemino-Hypoglossal Reflex in Rats.

Curr Issues Mol Biol 2022 May 23;44(5):2401-2416. Epub 2022 May 23.

Department of Neurology, Medical University of Lodz, Kopcinskiego 22, 90-153 Lodz, Poland.

The endocannabinoid system (ECS) plays an important role in pain processing and modulation. Since the specific effects of endocannabinoids within the orofacial area are largely unknown, we aimed to determine whether an increase in the endocannabinoid concentration in the cerebrospinal fluid (CSF) caused by the peripheral administration of the FAAH inhibitor URB597 and tooth pulp stimulation would affect the transmission of impulses between the sensory and motor centers localized in the vicinity of the third and fourth cerebral ventricles. The study objectives were evaluated on rats using a method that allowed the recording of the amplitude of evoked tongue jerks (ETJ) in response to noxious tooth pulp stimulation and URB597 treatment. Read More

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[A case of Coexistent Persistent Trigeminal and Hypoglossal Arteries Manifested with Neurovascular Compression Syndrome by Hypertension].

Brain Nerve 2022 Jun;74(6):811-816

Department of Neurology, Shimane University Faculty of Medicine.

A 70-year-old woman visited our hospital with hypertension, diplopia, and right orbital pain. Neurological examination revealed right ophthalmoplegia. CT angiography and MRI identified a right persistent trigeminal artery (PTA), right persistent hypoglossal artery, and bovine aortic arch. Read More

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Malignancies in Immunoglobulin G4-related ophthalmic disease.

Eur J Ophthalmol 2022 Jun 8:11206721221102274. Epub 2022 Jun 8.

Department of Ophthalmology and Visual Sciences, 13621Prince of Wales Hospital, Hong Kong.

Purpose: Clinical phenotypes in Immunoglobulin G4-related disease (IgG4-RD) according to the patterns of affecting organs have different risks of malignancies. We attempt to determine the association of malignancies with IgG4-related ophthalmic disease (IgG4-ROD).

Design: Retrospective cohort study. Read More

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Secondary trigeminal neuralgia diagnosed in orofacial pain setting as epidermoid tumor.

Quintessence Int 2022 Jun;53(7):624-630

This case report describes the rare occurrence of an epidermoid tumor compressing the ipsilateral trigeminal nerve resulting in secondary trigeminal neuralgia. MRI is the imaging modality of choice for the diagnosis of secondary trigeminal neuralgia. The epidermoid tumor was discovered by an orofacial pain specialist after reassessing the MRI study, previously reported as normal. Read More

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