25,494 results match your criteria Trigeminal Nerve


Involvement of Multiple Trigeminal Nerve Branches in IgG4-Related Orbital Disease.

Ophthalmic Plast Reconstr Surg 2020 Jun 4. Epub 2020 Jun 4.

Pathology Department, School of Medicine of Ribeirão-Preto, University of São Paulo, São Paulo, Brazil.

Purpose: To describe the occurrence of multiple trigeminal nerves (TGNs) enlargement in patients with orbital IgG4-related disease.

Methods: Retrospective review of MRI findings and medical records of 6 patients (10 orbits) with orbital IgG4-related disease and enlargement of more than 1 TGN. Orbital biopsies were performed in all cases revealing the typical lymphoplasmacytic infiltrate with significant plasma cell positivity for IgG4 (IgG4+/IgG ratio ≥ 40%). Read More

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http://dx.doi.org/10.1097/IOP.0000000000001733DOI Listing

c-Abl-p38 signaling pathway mediates dopamine neuron loss in trigeminal neuralgia.

Mol Pain 2020 Jan-Dec;16:1744806920930855

Department of Pain, The Affiliated Hospital of Southwest Medical University, Luzhou, China.

Trigeminal neuralgia is a common neuropathic pain in the head and face. The pathogenesis of trigeminal neuralgia is complex, and so far, the pathogenesis of trigeminal neuralgia involving peripheral and central nervous inflammation theory has not been explained clearly. The loss of dopamine neurons in striatum may play an important role in the development of trigeminal nerve, but the reason is not clear. Read More

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http://dx.doi.org/10.1177/1744806920930855DOI Listing

Parasellar Meningiomas.

Neuroendocrinology 2020 Jun 3. Epub 2020 Jun 3.

Parasellar spaces remain particularly singular, comprising most important neurovascular structures as internal carotid artery, optic, oculomotor and trigeminal nerves. Meningiomas are one of the most frequent tumors arising from parasellar spaces. In this location, meningiomas remain mostly benign tumors with WHO grade I and meningothelial subtype. Read More

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http://dx.doi.org/10.1159/000509090DOI Listing

Reliability of orofacial quantitative sensory testing for pleasantness and unpleasantness.

Cephalalgia 2020 Jun 2:333102420929700. Epub 2020 Jun 2.

Section of Orofacial Pain and Jaw Function, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Background: Quantitative sensory testing protocols for perceptions of pleasantness and unpleasantness based on the German Research Network on Neuropathic Pain protocol were recently introduced. However, there are no reliability studies yet published.

Aim: To evaluate the intra-examiner (test-retest) and inter-examiner reliability for orofacial pleasantness and unpleasantness quantitative sensory testing protocols. Read More

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http://dx.doi.org/10.1177/0333102420929700DOI Listing

CT-guided infiltration of greater occipital nerve for refractory craniofacial pain syndromes other than occipital neuralgia.

Diagn Interv Imaging 2020 May 29. Epub 2020 May 29.

Adult Radiology Department, Necker Hospital, Assistance-Publique-Hopitaux de Paris, Université de Paris, 75006 Paris, France.

Purpose: The purpose of this study was to evaluate the effectiveness of computed tomography (CT)-guided infiltration of greater occipital nerve (GON) for the treatment of refractory craniofacial pain syndromes other than occipital neuralgia.

Materials And Methods: Fifty-six patients suffering from refractory craniofacial pain syndromes were included between 2011 and 2017. There were 33 women and 23 men with a mean age of 50. Read More

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http://dx.doi.org/10.1016/j.diii.2020.05.006DOI Listing

Spontaneous Axonal Dystrophy in the Brain and Spinal Cord in Naïve Beagle Dogs.

Toxicol Pathol 2020 Jun 1:192623320926475. Epub 2020 Jun 1.

Global Pathology and Investigative Toxicology, Pfizer Inc, Groton, CT, USA.

Axonal dystrophy (AD) is a common age-related neurohistological finding in vertebrates that can be congenital or induced by xenobiotics, vitamin E deficiency, or trauma/compression. To understand the incidence and location of AD as a background finding in Beagle dogs used in routine toxicity studies, we examined central nervous system (CNS) and selected peripheral nervous system (PNS) tissues in twenty 18- to 24-month-old and ten 4- to 5-year-old control males and females. Both sexes were equally affected. Read More

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http://dx.doi.org/10.1177/0192623320926475DOI Listing

Analysis of Tooth Innervation in Microfluidic Coculture Devices.

Methods Mol Biol 2020 ;2155:99-106

Unit of Orofacial Development and Regeneration, Institute of Oral Biology, University of Zurich, Zurich, Switzerland.

Innervation plays a key role in the development, homeostasis, and regeneration of organs and tissues. However, the mechanisms underlying these phenomena are not well understood yet. In particular, the role of innervation in tooth development and regeneration is neglected. Read More

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http://dx.doi.org/10.1007/978-1-0716-0655-1_8DOI Listing
January 2020

Augmented Visualization Surgical Microscope Assisted Microvascular Decompression for Hemifacial Spasm.

Otol Neurotol 2020 May 28. Epub 2020 May 28.

University of Connecticut, School of Medicine, Farmington, Connecticut.

: Microvascular decompression (MVD) is curative treatment for primary Hemifacial Spasm, in cases where a vascular loop impinges on the facial nerve. Surgical techniques for MVD may be extended to MVD of the glossopharyngeal nerve and trigeminal nerve in cases of primary glossopharyngeal neuralgia and trigeminal neuralgia. Stroke is a rare complication of these procedures that may occur during the separation of a vascular loop from nervous tissue, particularly when materials such as Teflon are used to separate the structures. Read More

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http://dx.doi.org/10.1097/MAO.0000000000002717DOI Listing

Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging.

J Headache Pain 2020 May 29;21(1):59. Epub 2020 May 29.

Department of Anatomy and Histology, F13, University of Sydney, Sydney, NSW, 2006, Australia.

Background: There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migraine pathophysiology. Whilst it is not possible to explore the anatomy of small trigeminal nerve branches it is possible to explore the anatomy of the trigeminal root entry zone using magnetic resonance imaging in humans. Read More

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http://dx.doi.org/10.1186/s10194-020-01126-1DOI Listing

Melanotic Schwannoma, a Deceptive Misnomer for a Tumor With Relative Aggressive Behavior: A Series of 7 Cranial and Spinal Cases.

Int J Surg Pathol 2020 May 26:1066896920923146. Epub 2020 May 26.

Tata Memorial Hospital and ACTREC, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, India.

The authors present in this article a series of 7 intracranial/spinal cases of melanotic schwannomas that highlight the aggressive nature of these tumors. The series comprises 2 males and 5 females, age range 19 to 50 years, with spinal/paraspinal location in 4/7 (57%), and intracranial (along the trigeminal nerve) location in 3/7 (43%). There was no association with Carney's complex. Read More

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http://dx.doi.org/10.1177/1066896920923146DOI Listing

COVID-19 and herpes zoster co-infection presenting with trigeminal neuropathy.

Eur J Neurol 2020 May 24. Epub 2020 May 24.

Fluminense Federal University, Neurology Department, Rio de Janeiro, Brazil.

Background: Varicella-zoster virus (VZV) is a human neurotropic virus that remains in a latent state within ganglionic neurons throughout the entire neuroaxis after the primary infection. Whenever herpes zoster leads to trigeminal involvement, the ophthalmic division is the most implicated. COVID-19 emerged as a viral cause of severe acute respiratory syndrome that spread all over the world in the last months. Read More

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http://dx.doi.org/10.1111/ene.14361DOI Listing

Factors affecting outcome in frameless non-isocentric stereotactic radiosurgery for trigeminal neuralgia: a multicentric cohort study.

Radiat Oncol 2020 May 22;15(1):115. Epub 2020 May 22.

Brain Radiosurgery, CDI Centro Diagnostico Italiano, Milan, Italy.

Background: Stereotactic radiosurgery (SRS) is an effective treatment for trigeminal neuralgia (TN). Nevertheless, a proportion of patients will experience recurrence and treatment-related sensory disturbances. In order to evaluate the predictors of efficacy and safety of image-guided non-isocentric radiosurgery, we analyzed the impact of trigeminal nerve volume and the nerve dose/volume relationship, together with relevant clinical characteristics. Read More

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http://dx.doi.org/10.1186/s13014-020-01535-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243318PMC

The Therapeutic Effectiveness of Full Spectrum Hemp Oil Using a Chronic Neuropathic Pain Model.

Life (Basel) 2020 May 18;10(5). Epub 2020 May 18.

Department of Anesthesiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.

Background: Few models exist that can control for placebo and expectancy effects commonly observed in clinical trials measuring '' pharmacodynamics. We used the Foramen Rotundum Inflammatory Constriction Trigeminal Infraorbital Nerve injury (FRICT-ION) model to measure the effect of "full-spectrum" whole plant extracted hemp oil on chronic neuropathic pain sensitivity in mice.

Methods: Male BALBc mice were submitted to the FRICT-ION chronic neuropathic pain model with oral insertion through an incision in the buccal/cheek crease of 3 mm of chromic gut suture (4-0). Read More

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http://dx.doi.org/10.3390/life10050069DOI Listing

Using the Lateral Pontine Safe Entry Zone for Resection of Deep-Seated Cavernous Malformations in the Lateral Pons: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 May 22. Epub 2020 May 22.

Department of Neurosurgery, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Brazil.

The retrosigmoid approach is one of the main approaches used in the surgical management of pontine cavernous malformations. It definitely provides a lateral route to large central lesions but also makes possible resection of some ventral lesions as an alternative to the petrosal approaches. However, when these vascular malformations do not emerge on surface, one of the safe corridors delimited by the origin of the trigeminal nerve and the seventh-eight cranial nerve complex can be used. Read More

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http://dx.doi.org/10.1093/ons/opaa142DOI Listing

[Lower teeth anesthesia in patients with limited mouth opening].

Stomatologiia (Mosk) 2020 ;99(2):105-109

First I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Limited mouth opening is a common pathology in dental practice. Dental treatment of these group patients is hindered by low access to oral cavity, which complicates operative, prosthetic and surgical interventions. Local anesthesia is also difficult due to changes in anatomical landmarks, changes in bone structures and soft tissues ratio. Read More

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http://dx.doi.org/10.17116/stomat202099021105DOI Listing

[Maxillofacial manifestations in children and adolescents with neurofibromatosis 1].

Stomatologiia (Mosk) 2020 ;99(2):85-90

Central Research Institute of Dentistry and Maxillofacial Surgery, Moscow, Russia.

The aim of the study was to summarize literature data on oral and maxillofacial manifestations of neurofibromatosis I (NFI) and to analyze clinical case in with dentist had the leading role in proper diagnosis of the disease. Literature review showed main oral alterations in NFI to be: neurofibroma formation seen in 8-14% of children and adolescents, dysplastic «orthodontic» phenotype with shortened mandible, maxilla and sphenoid bones; radiologic signs including alveolar nerve canal and mental foramen widening in almost one third of patients; lesions of cranial nerves (mainly trigeminal, facial and glossopharyngeal), with non-specific paralysis clinic. These symptoms, however, develop gradually throughout the life and may be evident only in late adolescents. Read More

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http://dx.doi.org/10.17116/stomat20209902185DOI Listing

Efficacy and Safety of Percutaneous Ozone Injection Around Gasserian Ganglion for the Treatment of Trigeminal Neuralgia: A Multicenter Retrospective Study.

J Pain Res 2020 4;13:927-936. Epub 2020 May 4.

Department of Anesthesiology, Weifang Medical University, Weifang City 261000, Shangdong, People's Republic of China.

Background: Ozone injection around Gasserian ganglion (OIAGG) has been reported to be an effective treatment for trigeminal neuralgia (TN); however, there remain areas for improvement. To overcome one of these limitations, a multicenter examination of application would be extremely helpful.

Objective: The goal of this report was to assess the efficacy of OIAGG for refractory TN across multiple centers and to explore factors predictive of successful treatment. Read More

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http://dx.doi.org/10.2147/JPR.S232081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210028PMC

Diffusion tensor imaging reveals microstructural alteration of the trigeminal nerve root in classical trigeminal neuralgia without neurovascular compression and correlation with outcome after internal neurolysis.

Magn Reson Imaging 2020 May 19;71:37-44. Epub 2020 May 19.

Department of Neurosurgery, The First Affiliated Hospital of USTC (Anhui Provincial Hospital), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, PR China; Anhui Provincial Stereotactic Neurosurgical Institute, Hefei, Anhui, 230001, PR China; Anhui Provincial Key Laboratory of Brain Function and Disease, Hefei, Anhui, 230001, PR China.

Objectives: Diffusion tensor imaging (DTI) has been used to detect microstructural alteration and effect of surgical treatment of the trigeminal nerve root (TR) in patients with classical trigeminal neuralgia (CTN) underwent microvascular decompression (MVD). Patients with CTN without neurovascular compression (woNVC) is a special population of TN, however, the pathogenesy of CTN woNVC and the mechanism of internal neurolysis (IN) remain unknown.

Materials And Methods: 21 patients with CTN woNVC who underwent IN and 20 healthy controls were included in this study. Read More

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http://dx.doi.org/10.1016/j.mri.2020.05.006DOI Listing

The role of peripheral opioid receptors in orofacial pain.

Oral Dis 2020 May 21. Epub 2020 May 21.

Department of Pediatric Dentistry, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, China.

Opioid receptors are widely distributed in the central and peripheral nervous systems and non-neuronal tissues. Numerous researchers have noted the pivotal role of peripheral opioid receptors (PORs) in analgesia. Accumulating evidence has shown the existence of PORs in the trigeminal nerve system, indicating that PORs may be involved in the modulation of orofacial pain. Read More

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http://dx.doi.org/10.1111/odi.13435DOI Listing

The location of the inferior alveolar nerve in the malaysian population: Implications for dental implant planning.

Indian J Dent Res 2020 Mar-Apr;31(2):197-202

Medical Genetics Laboratory, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang; Department of Biological Sciences, School of Science and Technology, Sunway University, Sunway, Malaysia.

Background: The location of the inferior alveolar nerve (IAN) is generally constant in fully grown mandibles. If we know its average distance from the lower border of the mandible, available bone length from the crest of the edentulous ridge can be estimated by physical measurement of the whole length of mandible in that area. This study aimed to measure the superio-inferior distance of the inferior alveolar nerve (SIDIAN) from the base of the mandible in posterior regions on the right and left side based on cone-beam-computed tomography (CBCT) scans and to evaluate gender and ethnicity-related variations in the Malaysian population. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_553_17DOI Listing

[Microvascular Decompression to Treat Abducens Nerve Paralysis Caused by Compression of the Anterior Inferior Cerebellar Artery:A Case Report].

No Shinkei Geka 2020 May;48(5):429-434

Department of Neurosurgery, Faculty of Medicine, Fukuoka University.

Microvascular decompression(MVD)is an effective treatment for hemifacial spasm and trigeminal neuralgia. However, there are few reports regarding its use with abducens nerve palsy. Here, we report the case of a 77-year-old male who presented with diplopia and was admitted to our facility for right abducens nerve palsy. Read More

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http://dx.doi.org/10.11477/mf.1436204205DOI Listing

A systematic review on persistent trigeminal artery, in searching for a therapeutic solution to idiopathic and unresponsive trigeminal nerve inflammations and migraines.

J Biol Regul Homeost Agents 2019 Nov-Dec;33(6 Suppl. 2):155-169

Pham Ngoc Thac University of Medicine, Department of Histology, Embryology and Genetics, Ho Chi Minh City, Vietnam.

The rarely diagnosed persistent trigeminal artery (PTA) originates from the posterior bend or lateral wall of the intracavernous carotid artery and is the most common occurring type of remnant primitive fetal arteries. Even if PTA is uncommon, information and awareness about it could be of great help for clinicians dealing with cranial vascular imaging and operating this region. In addition, it could give a supporting response to the presence of a wide range of idiopathic and unresponsive disturbs that sometimes are erroneously interpreted and treated. Read More

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Chronic migraine-cephalgia related to trigeminal artery: a case report of innovative regenerative approach.

J Biol Regul Homeost Agents 2019 Nov-Dec;33(6 Suppl. 2):23-29

Research Laboratory in Regenerative Medicine and Tissue Engineering Saint Camillus International University of Health Sciences, Rome, Italy.

Persistent trigeminal artery (PTA) originates from the posterior bend or lateral wall of the intra-cavernous carotid artery and is the most common occurring type of remnant primitive fetal arteries. In literature, there is limited number of reports on migraine-cephalgia (MC) associated with coexisting PTA. The primitive anastomose arteries that fully belong to the intracranial arterial vascular system are not supposed to perform any supportive functional activity; usually they are subjected to normal biological decay caused by the aging process and metabolic dysfunctions. Read More

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Prediction of trigeminal nerve position based on the main feeding artery in petroclival meningioma.

Neurosurg Rev 2020 May 18. Epub 2020 May 18.

Department of Neurosurgery, School of Medicine, Fujita Health University, 1-98, Kutsugake Dengakugakubo, Toyoake City, Aichi, 470-1192, Japan.

The trigeminal nerve is often displaced by petroclival meningioma (PCM) compression, making it difficult to locate during PCM surgery. This study investigated whether the deviated position of the trigeminal nerve could be easily predicted using the main tumor feeding artery. We retrospectively examined 32 patients who underwent surgery for primary PCM. Read More

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http://dx.doi.org/10.1007/s10143-020-01313-3DOI Listing

Trigeminal Trophic Syndrome Secondary to Refractory Trigeminal Neuralgia Treated with CyberKnife® Radiosurgery.

Cureus 2020 Apr 14;12(4):e7670. Epub 2020 Apr 14.

Radiation Oncology, Cyberknife Centre, Ruber Internacional, Madrid, ESP.

Trigeminal trophic syndrome (TTS) is a rare condition in which there is the involvement of the skin innervated by branches of the trigeminal nerve. Because of an alteration in the sensory function of the trigeminal nerve, an exaggerated manipulation of the skin by the patient occurs, with secondary ulcers in the affected areas. They are usually unilateral and located mainly at the beginning of the nose wing. Read More

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http://dx.doi.org/10.7759/cureus.7670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226666PMC

Mechanism underlying cranial nerve rhizopathy.

Med Hypotheses 2020 May 6;142:109801. Epub 2020 May 6.

Dept. Neurosurgery, XinHua Hospital, Shanghai JiaoTong University School of Medicine, 1665 KongJiang Rd., Shanghai 200092, China. Electronic address:

The cranial nerve rhizophathy, commonly presented with trigeminal neuralgia (TN) or hemifacial spasm (HFS), is a sort of hyperexcitability disorders with higher incidence in senior Asian. In this paper, a novel hypothesis on the pathogenesis is proposed and with which some clinical phenomena are explained. In those with crowded cerebellopontine angle in anatomy, the cranial nerve root and surrounding vessel are getting closer and closer to each other with aging and finally the neurovascular conflict happens. Read More

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http://dx.doi.org/10.1016/j.mehy.2020.109801DOI Listing

COVID-19 is a Real Headache!

Headache 2020 May 15. Epub 2020 May 15.

Istanbul Faculty of Medicine, Department of Neurology, Headache Center, Istanbul University, Istanbul, Turkey.

After the emergence of a novel coronavirus named SARS-CoV-2, coronavirus disease 2019 (COVID-19) was initially characterized by fever, sore throat, cough, and dyspnea, mainly manifestations of respiratory system. However, other manifestations such as headache, abdominal pain, diarrhea, loss of taste and smell were added to the clinical spectrum, during the course of the COVID-19 pandemic. The reports on the neurological findings are increasing rapidly and headache seems to be the leader on the symptom list. Read More

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http://dx.doi.org/10.1111/head.13856DOI Listing

The Successful Treatment of Severe Trigeminal Neuralgia by a Single Mandibular Nerve Block and Subsequent Natalizumab Administration in a Patient with Multiple Sclerosis.

Cureus 2020 Apr 12;12(4):e7646. Epub 2020 Apr 12.

Neurology, Tokyo Metropolitan Neurological Hospital, Tokyo, JPN.

We report the case of a middle-aged woman who developed trigeminal neuralgia as a sequela of multiple sclerosis (MS). The trigeminal neuralgia was refractory to medications and persisted for two years. Eventually, it was resolved by a mandibular nerve block followed by natalizumab administration. Read More

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http://dx.doi.org/10.7759/cureus.7646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7217241PMC

Success of surgical interventions for direct dental implant-related injuries to the mandibular nerve: a review.

Authors:
L M Fee

Br J Oral Maxillofac Surg 2020 May 11. Epub 2020 May 11.

BA BDS, MSc in Dental Implants(Bristol University), Diploma in Pimary Care Oral Surgery, RCS(Eng), Diploma in Conscious Sedation (Newcastle University), Cert in Clinical Education (Edinburgh University).

To the best of our knowledge there are no guidelines regarding the surgical management of dental implant-related injuries to the mandibular nerve. This review aims to investigate the success of different surgical interventions. Neurosensory injury to the mandibular branch of the trigeminal nerve can occur during administration of local anaesthetic, elevation of the flap, preparation for osteotomy, and placement of the implant. Read More

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http://dx.doi.org/10.1016/j.bjoms.2020.04.012DOI Listing

Ablation of TRPV1+ Afferent Terminals by Capsaicin Mediates Long-Lasting Analgesia for Trigeminal Neuropathic Pain.

eNeuro 2020 May/Jun;7(3). Epub 2020 May 29.

Department of Neural and Pain Sciences, School of Dentistry, University of Maryland, Program in Neuroscience, Center to Advance Chronic Pain Research, Baltimore, MD 21201

Trigeminal neuropathic pain (TNP) is often resistant to current pharmacotherapy, and there is a pressing need to develop more efficacious treatments. Capsaicin is a pungent ingredient of chili peppers and specifically activates transient receptor potential vanilloid subtype 1 (TRPV1), a Ca-permeable ion channel. Topical capsaicin invariably induces burning pain. Read More

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http://dx.doi.org/10.1523/ENEURO.0118-20.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7266139PMC

A systematic review on diagnostic test accuracy of magnetic resonance neurography versus clinical neurosensory assessment for post-traumatic trigeminal neuropathy in patients reporting neurosensory disturbance.

Dentomaxillofac Radiol 2020 May 27:20200103. Epub 2020 May 27.

Department of Imaging and Pathology, OMFS-IMPATH Research Group, Faculty of Medicine, University Leuven, Leuven, Belgium.

Objectives: To perform a systematic review of published studies on diagnostic accuracy of magnetic resonance neurography (MRN) clinical neurosensory testing (NST) for post-traumatic trigeminal neuropathy (PTTN) in patients reporting neurosensory disturbances (NSD).

Methods: Human studies except case reports, reviews, systematic reviews and meta-analyses were included. PubMed, Embase, Web of Science and Cochrane Library were consulted. Read More

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http://dx.doi.org/10.1259/dmfr.20200103DOI Listing

Analgesic effects of the CTK 01512-2 toxin in different models of orofacial pain in rats.

Pharmacol Rep 2020 May 12. Epub 2020 May 12.

Laboratory of Pharmacology, Lutheran University of Brazil (ULBRA), Av. Farroupilha, no 8001, Bairro São José, Canoas, Rio Grande do Sul, CEP 92425-900, Brazil.

Background: Orofacial pain is clinically challenging, having therapeutic failures and side effects. This study evaluated the antinociceptive activities of the CTK 01512-2 toxin, the TRPA1 channel antagonist, and the selective inhibitor of the N-type voltage-gated calcium channels (N-type VGCC), in different pain models.

Materials And Methods: The trigeminal ganglia were stimulated in vitro with capsaicin. Read More

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http://dx.doi.org/10.1007/s43440-020-00108-zDOI Listing

An Association of Varicella Zoster Virus, Facial Palsy, and Meningitis in a Young Immunocompetent Male.

Case Rep Neurol 2020 Jan-Apr;12(1):136-139. Epub 2020 Apr 28.

Department of Medical Education, Hamad Medical Corporation, Doha, Qatar.

Varicella zoster is a secondary infection caused by the virus of chickenpox, after becoming latent in neurons of dorsal root ganglia or trigeminal ganglia. Varicella zoster virus (VZV) can be reactivated years later to produce shingles (zoster), generally in immunocompromised adults to produce neurological deficits and rash. Meningeal involvement of VZV is also reported and can be diagnosed. Read More

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http://dx.doi.org/10.1159/000506192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7204867PMC

Isolated Internal Ophthalmoplegia Secondary to Herpes Zoster Ophthalmicus: A Rare Case Report.

Neuroophthalmology 2020 Apr 12;44(2):118-120. Epub 2019 Jul 12.

Department of Neurology, Ege University, İzmir, Turkey.

Herpes zoster becomes latent in the sensory ganglia after the primary infection and may reactivate many years later to produce shingles in adults. Involvement of the ophthalmic branch of the trigeminal nerve with this virus is called Herpes zoster ophthalmicus (HZO). The eyelid skin, cornea, uvea, retina, optic nerve and other cranial nerves can be affected by HZO. Read More

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http://dx.doi.org/10.1080/01658107.2019.1618343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202423PMC

Diffuse large B cell lymphoma involving Meckel's cave masquerading as biopsy-negative giant cell arteritis: a case report.

J Med Case Rep 2020 May 10;14(1):57. Epub 2020 May 10.

Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, MN, 55905, USA.

Background: Given the absence of consensus diagnostic criteria for giant cell arteritis, clinicians may encounter difficulty with identification of new-onset headache in patients older than age 50 years presenting with visual changes and elevated inflammatory markers, particularly if temporal artery biopsies are performed and negative.

Case Presentation: We present a case of a 57-year-old white man with headache, diplopia, and jaw paresthesia initially diagnosed and managed as steroid-refractory biopsy-negative giant cell arteritis. Further investigation disclosed evidence of soft tissue infiltration into Meckel's (trigeminal) cave bilaterally. Read More

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http://dx.doi.org/10.1186/s13256-020-02379-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7211338PMC

Orofacial pain secondary to acoustic neuroma-A case report.

Spec Care Dentist 2020 May 8;40(3):303-307. Epub 2020 May 8.

Department of Restorative Dentistry, Federal University of Ceará, Fortaleza, Ceará, Brazil.

Aim: The present study aimed to report a case of orofacial pain secondary to acoustic neuroma (AN).

Methods And Results: A 66-year-old female presented with unilateral facial pain and odontalgia. The pain was described as throbbing, dull, and constant. Read More

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http://dx.doi.org/10.1111/scd.12461DOI Listing

Predictors of the analgesic efficacy of CT-guided percutaneous pulsed radiofrequency treatment of Gasserian ganglion in patients with idiopathic trigeminal neuralgia.

Pain Pract 2020 May 7. Epub 2020 May 7.

Department of Pain Management, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Aims: Although pulsed radiofrequency (PRF) has few postoperative adverse reactions, its analgesic efficacy for trigeminal neuralgia is not always guaranteed. The response rate of PRF targeting the Gasserian ganglion for patients with trigeminal neuralgia (TN) varies. This study aims to identify the predictors of the analgesic efficacy of CT-guided percutaneous PRF in patients with idiopathic TN. Read More

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http://dx.doi.org/10.1111/papr.12910DOI Listing

Requirement of the Preservation of Mental Nerve During the Transfer of Depressor Anguli Oris Composite Flap.

Sisli Etfal Hastan Tip Bul 2019 26;53(3):256-262. Epub 2019 Aug 26.

Department of Plastic Reconstructive and Aesthetic Surgery, Uludag Faculty of Medicine, Bursa, Turkey.

Objectives: Reconstruction of wide lower lip defects is still a challenging subject in terms of obtaining functional and aesthetically acceptable results. Lower lip reconstruction with depressor anguli oris muscle was first described by Tobin in 1983. Since the sensory innervation of this composite muscle flap is provided by the mental nerve, it has been advocated that the mental nerve should be preserve during flap elevation. Read More

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http://dx.doi.org/10.14744/SEMB.2019.04578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7192271PMC

Increased risk of tinnitus following a trigeminal neuralgia diagnosis: a one-year follow-up study.

J Headache Pain 2020 May 6;21(1):46. Epub 2020 May 6.

Department of Health Care Administration, Taipei Medical University, 250 Wu-Hsing St, Taipei, 110, Taiwan.

Background: Tinnitus due to hyperactivity across neuronal ensembles along the auditory pathway is reported. We hypothesized that trigeminal neuralgia patients may subsequently suffer from tinnitus. Using nationwide, population-based data and a retrospective cohort study design, we investigated the risk of tinnitus within 1 year following trigeminal neuralgia. Read More

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http://dx.doi.org/10.1186/s10194-020-01121-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7203585PMC

Atypical Teratoid/Rhabdoid Tumor Originated From the Trigeminal Nerve in a Young Male Adult: Case Report and Review of the Literature.

Front Neurol 2020 21;11:265. Epub 2020 Apr 21.

Department of Neurosurgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant central nervous system neoplasm predominantly found in children under the age of 3 years, and is extremely rare in adults. There is no specific clinical presentations or radiological features in reported cases of AT/RT. Diagnosis of brain AT/RT is mainly dependent on the classical pathological characteristics. Read More

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http://dx.doi.org/10.3389/fneur.2020.00265DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186469PMC

Local Administration of Methylcobalamin for Subacute Ophthalmic Herpetic Neuralgia: A Randomized, Phase III Clinical Trial.

Pain Pract 2020 May 6. Epub 2020 May 6.

Rehabilitation Medicine Department, Chongming Branch of Shanghai Tenth People's Hospital, Shanghai, China.

Objectives: The ophthalmic branch of the trigeminal nerve is one of the most frequently involved sites of postherpetic neuralgia. A single-center randomized controlled study was conducted to evaluate the efficacy of local methylcobalamin injection for subacute ophthalmic herpetic neuralgia (SOHN).

Methods: One hundred and five patients with a pain score of 4 or greater were randomized to receive a combination of methylcobalamin and lidocaine via local injection (LM group, n = 35), intramuscular methylcobalamin and local lidocaine injection (IM group, n = 35), and oral methylcobalamin tablet and lidocaine local injection (OM group, n = 35) for 4 weeks. Read More

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http://dx.doi.org/10.1111/papr.12909DOI Listing
May 2020
2.361 Impact Factor

Tolosa-Hunt Syndrome: A Non-Classical Presentation of a Rare Cause of Unilateral Headache and Painful Ophthalmoplegia.

J Clin Med Res 2020 Apr 30;12(4):266-268. Epub 2020 Mar 30.

Department of Medicine, Jersey Shore University Medical Center, Hackensack Meridian Health, Neptune, NJ 07753, USA.

Tolosa-Hunt syndrome is a rare condition involving the orbital and retro-orbital space. The typical symptoms are orbital pain, swelling, headache, palsies of the cranial nerves, and sensory loss in the distribution of the trigeminal nerve. Tolosa-Hunt syndrome relapses and remits with episodes separated by months to years. Read More

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http://dx.doi.org/10.14740/jocmr4123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188369PMC

Surgical Treatment of Symptomatic Small Medial Petrous Meningiomas Causing Trigeminal Neuralgia.

World Neurosurg 2020 Apr 29. Epub 2020 Apr 29.

Department of Neurosurgery, University of Arkansas Medical Sciences, Little Rock, Arkansas, USA. Electronic address:

Background: Symptomatic trigeminal neuralgia caused by small (<3 cm) skull base meningiomas is treated by radiosurgery or surgical resection. Although radiosurgery is less invasive, surgical resection provides more rapid resolution of symptoms. We reviewed a short series of patients who underwent an anterior transpetrosal approach for surgical resection of meningiomas causing trigeminal neuralgia. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.04.127DOI Listing

Surgical Management of the Trigeminocerebellar Artery in Microvascular Decompression for Trigeminal Neuralgia.

Oper Neurosurg (Hagerstown) 2020 May 1. Epub 2020 May 1.

Department of Neurosurgery, Koto Memorial Hospital, Higashiohmi, Japan.

Background: The trigeminocerebellar artery (TCA) is a variant branch of the basilar artery supplying the trigeminal nerve root and cerebellar hemisphere, which may contribute to trigeminal neuralgia (TGN). Despite its unique anatomic description, information regarding the preoperative diagnosis and surgical management of TCA is lacking.

Objective: To evaluate our preoperative diagnosis of TCA using 3-dimensional (3D) images and surgical management of TGN cases with TCA involvement. Read More

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http://dx.doi.org/10.1093/ons/opaa097DOI Listing

Reflexes that impact spontaneous breathing of preterm infants at birth: a narrative review.

Arch Dis Child Fetal Neonatal Ed 2020 Apr 29. Epub 2020 Apr 29.

Neonatology, Leiden University Medical Center, Leiden, The Netherlands.

Some neural circuits within infants are not fully developed at birth, especially in preterm infants. Therefore, it is unclear whether reflexes that affect breathing may or may not be activated during the neonatal stabilisation at birth. Both sensory reflexes (eg, tactile stimulation) and non-invasive ventilation (NIV) can promote spontaneous breathing at birth, but the application of NIV can also compromise breathing by inducing facial reflexes that inhibit spontaneous breathing. Read More

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http://dx.doi.org/10.1136/archdischild-2020-318915DOI Listing

Expanded Endonasal Approach for Resection of Extradural Infratemporal Fossa Trigeminal Schwannoma: 2-Dimensional Operative Video.

Oper Neurosurg (Hagerstown) 2020 Apr 29. Epub 2020 Apr 29.

Skull Base, Pituitary, and Endoscopy Center, Department of Otolaryngology, Henry Ford Health System, Detroit, Michigan, USA.

The infratemporal fossa (ITF) is bounded superiorly by the skull base, specifically the greater wing of the sphenoid, which contains foramen ovale. It is bordered posteriorly by the temporal bone, including the petrous portion of the carotid canal, anteriorly by the posterior wall of the maxillary sinus, laterally by the mandible, and medially by the pterygoid body and lateral pterygoid plate.1-3 In this video, we report a case of a rare, exclusively extradural, schwannoma originating from the third division of the trigeminal nerve with a widened foramen ovale at the skull base. Read More

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http://dx.doi.org/10.1093/ons/opaa102DOI Listing