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World J Cardiol 2022 Apr;14(4):206-219

Department of Cardiology, National Institute of Cardiovascular Diseases, Dhaka 1207, Bangladesh.

Cardiac myxomas are common primary neoplasms of the heart. They are biologically benign but "functionally malignant" because of the potential for embolization. They arise most commonly from the left atrium, but no chambers of the heart are immune. Read More

World J Clin Cases 2022 Apr;10(11):3547-3552

Department of Central Laboratory, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, China.

Background: Simultaneous cerebral and myocardial infarction with arterial involvement has not been reported in hypereosinophilic syndrome (HES). Here, we report a patient with HES that was also associated with acute ischemic stroke, myocardial infarction, and arterial involvement of the left common carotid artery, vertebral arteries, posterior cerebral artery, and coronary artery.

Case Summary: A 64-year-old male patient was admitted with headache and right lower extremity weakness. Read More

Rev Esp Cardiol (Engl Ed) 2022 May 12. Epub 2022 May 12.

Departamento de Cardiología, Hospital Clínico Universitario de Valladolid, Valladolid, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (CIBERCV), Spain. Electronic address:

Introduction And Objectives: We aimed to describe the feasibility and preliminary outcomes of commissural alignment (CA) for the balloon-expandable transcatheter heart valve.

Methods: The relationship among native commissures and transcatheter aortic valve implantation neocommissures was analyzed in 10 consecutive patients with tricuspid severe aortic stenosis undergoing transcatheter aortic valve implantation after guided implantation based on computed tomography analysis with a self-developed software. CA was predicted by in silico bio-modelling in the 10 patients and the calculated rotation was applied during crimping. Read More

J Clin Med 2022 May 9;11(9). Epub 2022 May 9.

Department of Cardiology, Rabin Medical Center, Petach Tikva 4941492, Israel.

The valve-in-valve (ViV) technique is an emerging alternative for the treatment of bioprosthetic structural valve deterioration (SVD) in the tricuspid position. We report on the outcomes of patients treated by a transcatheter tricuspid valve-in-valve (TT-ViV) implantation for symptomatic SVD in the tricuspid position during the years 2010-2019 at our center. Three main outcomes were examined during the follow-up period: TT-ViV hemodynamic data per echocardiography, mortality and NYHA functional class. Read More

United European Gastroenterol J 2022 May 13. Epub 2022 May 13.

Nuffield Department of Medicine, Translational Gastroenterology Unit, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK.

Background: PYRAMID was an international post-marketing registry that aimed to collect data on the long-term safety and effectiveness of adalimumab treatment per local standard of care in patients with moderately to severely active Crohn's disease (CD). Here, we present post hoc analyses of observational data from patients who became pregnant while participating in this registry and receiving adalimumab.

Methods: From the subpopulation of patients receiving adalimumab who became pregnant while taking part in PYRAMID, data on patient characteristics, pregnancy outcomes, and complications of pregnancy were analysed retrospectively. Read More

Anatol J Cardiol 2022 May;26(5):414-418

Department of Cardiology, İstanbul University-Cerrahpaşa, Institute of Cardiology, İstanbul, Turkey.

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan;47(1):94-100

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.

Objectives: Due to the lack of large-sized pulmonary valved conduit products in clinical practice, hand-sewn expanded polytetrafluoroethylene (ePTFE) valved conduit has been used for right ventricular outflow tract (RVOT) reconstruction in many heart centers around the world. This study aims to summarize the early results of the ePTFE valved conduit and the sewing technology of the conduit in combination with the latest progress, and to provide a reference for the application of ePTFE valved conduit.

Methods: A total of 21 patients using ePTFE valved conduit for RVOT reconstruction in the Second Xiangya Hospital, Central South University from October 2018 to October 2020 were prospectively enrolled in this study. Read More

J Cardiovasc Electrophysiol 2022 May 11. Epub 2022 May 11.

Department of Cardiology, Heart and Lung Center, Helsinki University and Helsinki University Central Hospital, Helsinki, Finland.

Objective: Implantation depth and membranous septum (MS) length have been established as the predictors of new-onset conduction disturbance (CD) after transcatheter aortic valve replacement (TAVR) for tricuspid aortic valve (TAV) stenosis. However, little is known about the predictors with bicuspid aortic valve (BAV). This study investigated the role of MS length and implantation depth in predicting CD following TAVR with a balloon-expandable valve in patients with BAV. Read More

ESC Heart Fail 2022 May 11. Epub 2022 May 11.

Department of Cardiology, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan.

Aims: Data on B-type natriuretic peptide (BNP) levels and adverse outcomes in patients with moderate mixed aortic valve disease (MAVD), defined as moderate aortic stenosis (AS) and regurgitation (AR), are scarce. Therefore, this study investigated the impact of BNP on the clinical outcomes in such patients.

Methods And Results: Clinical data from 81 patients (mean age, 74. Read More

JACC Basic Transl Sci 2022 Apr 23;7(4):333-345. Epub 2022 Mar 23.

Section of Cardiovascular Medicine and Cardiovascular Research Center, Yale University School of Medicine, New Haven, Connecticut, USA.

Expression of a neuropilin-like protein, DCBLD2, is reduced in human calcific aortic valve disease (CAVD). DCBLD2-deficient mice develop bicuspid aortic valve (BAV) and CAVD, which is more severe in BAV mice compared with tricuspid littermates. In vivo and in vitro studies link this observation to up-regulated bone morphogenic protein (BMP)2 expression in the presence of DCBLD2 down-regulation, and enhanced BMP2 signaling in BAV, indicating that a combination of genetics and BAV promotes aortic valve calcification and stenosis. Read More

J Hum Genet 2022 May 9. Epub 2022 May 9.

Aix Marseille Univ, INSERM, Marseille Medical Genetics, U1251, Marseille, France.

Bicuspid aortic valve (BAV) is the most common congenital heart defect with a high index of heritability. Patients with BAV have different clinical courses and disease progression. Herein, we report three siblings with BAV and clinical differences. Read More

Circulation 2022 May 9. Epub 2022 May 9.

Department of Translational Data Science and Informatics, Geisinger, Danville, PA; Tempus Labs Inc, Chicago, IL; Department of Medicine, Geisinger, Danville, PA.

Timely diagnosis of structural heart disease improves patient outcomes, yet many remain underdiagnosed. While population screening with echocardiography is impractical, electrocardiogram (ECG)-based prediction models can help target high-risk patients. We developed a novel ECG-based machine learning approach to predict multiple structural heart conditions, hypothesizing that a composite model would yield higher prevalence and positive predictive values (PPVs) to facilitate meaningful recommendations for echocardiography. Read More

Trends Cardiovasc Med 2022 May 2. Epub 2022 May 2.

Department of Cardiothoracic Surgery, Lankenau Heart Institute, Lankenau Medical Center, Main Line Health, Wynnewood, PA, USA; Department of Cardiothoracic Surgery Research, Lankenau Institute for Medical Research, Wynnewood, Pennsylvania, USA.

Based on previous meta-analyses including immediate/1-year results, individuals with bicuspid aortic valve (BAV) stenosis can undergo TAVI with similar outcomes as those with tricuspid aortic valve (TAV), but with higher rates of periprocedural complications. The widespread belief is that BAV patients would have poor results in comparison with TAV patients after TAVI over time. Therefore, we performed a systematic review with meta-analysis with reconstructed time-to-event data of studies published by January 2022 to compare late outcomes of patients with BAV versus TAV who underwent TAVI. Read More

JACC Cardiovasc Interv 2022 May;15(9):965-975

Emory Structural Heart and Valve Center, Emory University School of Medicine, Atlanta, Georgia, USA. Electronic address: https://twitter.com/AdamGreenbaumMD.

Objectives: The aim of this study was to compare transcaval and transaxillary artery access for transcatheter aortic valve replacement (TAVR) at experienced medical centers in contemporary practice.

Background: There are no systematic comparisons of transcaval and transaxillary TAVR access routes.

Methods: Eight experienced centers contributed local data collected for the STS/ACC TVT Registry (Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy Registry) between 2017 and 2020. Read More

Hellenic J Cardiol 2022 May 1. Epub 2022 May 1.

First Department of Cardiology, National and Kapodistrian University, "Hippokration" Hospital, Athens, Greece.

Background: The ACURATE neo transcatheter aortic valve is a self-expanding device suitable for both transfemoral and transapical approach, but specific groups of patients are under-represented in clinical trials. We aim to provide a comprehensive systematic review on TAVI with ACURATE neo in those special populations.

Methods: TAVI in bicuspid aortic valve, TAVI in patients with small aortic annulus, TAVI for pure aortic regurgitation and valve-in-valve procedures, were systematically reviewed. Read More

Med Clin North Am 2022 May 4;106(3):545-555. Epub 2022 Apr 4.

Department of Internal Medicine, UC Davis School of Medicine, 4150 V Street, Suite 2400, Sacramento, CA 95817, USA.

Patients with valvular heart disease may present with or without symptoms. A thorough cardiac physical examination can identify patients who require further evaluation and management. Although the utility of different cardiac findings varies widely, diastolic murmurs indicate important underlying valvular pathology requiring further investigation, typically with echocardiography. Read More

Future Cardiol 2022 Apr 29. Epub 2022 Apr 29.

Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA.

To determine the prognosis of multivalvular disease in patients undergoing transcatheter aortic valve replacement (TAVR) for severe aortic stenosis. Patients undergoing TAVR for aortic stenosis with covariate-adjusted risk of mortality associated with concomitant valve disease (mitral regurgitation [MR], mitral stenosis [MS] or tricuspid regurgitation [TR]) were included. Moderate-to-severe MR was associated with increased mortality at 30 days (hazard ratio [HR]: 1. Read More

Echocardiography 2022 May 24;39(5):724-731. Epub 2022 Apr 24.

Paediatric Cardiology Unit, University of Campania "Luigi Vanvitelli", A.O.R.N. "Ospedali dei Colli", Naples, Italy.

Objectives: This study aimed to identify clinical, hemodynamic, or echocardiographic predictive features of persistent duct-dependency of pulmonary circulation (PDDPC) after effective percutaneous relief of pulmonary atresia with the intact ventricular septum (PA-IVS) or critical pulmonary stenosis (CPS).

Methods: From 2010 to 2021, 55 neonates with PA-IVS or CPS underwent percutaneous right ventricle (RV) decompression at our Institution. After successfully relief of critical obstruction, 27 patients (group I) showed PDDPC, whereas RV was able to support the pulmonary circulation in the remaining 28 patients (group II). Read More

Eur Heart J Case Rep 2022 Apr 23;6(4):ytac131. Epub 2022 Mar 23.

Department of Cardiology, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N, Denmark.

Background: Patients with severe tricuspid valve stenosis or dysfunction following degeneration of biological valve prosthesis in tricuspid position are complex, have substantial comorbidity, and very high surgical risk.

Case Summary: We report two cases with transcatheter tricuspid valve-in-valve implantation in patients with degenerated tricuspid bioprosthesis with transfemoral and transjugular access with Sapien 3 valve and MyVal, respectively.

Discussion: In patients with high surgical risk, transcatheter tricuspid valve implantation is a good alternative. Read More

Methodist Debakey Cardiovasc J 2022 1;18(1):7-9. Epub 2022 Apr 1.

Houston Methodist DeBakey Heart & Vascular Center, Houston, Texas, US.

Despite improvements and advancements in surgical technique, paravalvular leaks (PVL) continue to present a challenge when caring for patients with prosthetic valve disease. Paravalvular leaks result from dehiscence of the surgical ring from the mitral annulus. Some theories suggest that uneven distribution of collagen fibers in the mitral annulus leaves the posterior mitral annulus without a well-formed fibrous structure, which may predispose it to recurrent mechanical injury that leads to PVL. Read More

J Thorac Cardiovasc Surg 2022 Mar 16. Epub 2022 Mar 16.

Department of Cardiac Surgery, Royal Children's Hospital, Melbourne, Australia; University of Melbourne, Melbourne, Australia; Murdoch Children's Research Institute, Melbourne, Australia; Melbourne Centre of Cardiovascular Genomics and Regenerative Medicine; Melbourne, Australia. Electronic address:

Objective: We aimed to assess the long-term outcomes of children with isolated congenital aortic stenosis who underwent primary aortic valve repair.

Methods: Records of all children (n = 111) with isolated congenital aortic stenosis who underwent primary aortic valve repair between 1980 and 2016 were reviewed. An optimal operative outcome consisted of a residual left ventricular outflow tract peak systolic gradient <35 mm Hg and trivial or less aortic insufficiency. Read More

Int J Cardiol 2022 Apr 13. Epub 2022 Apr 13.

l'institut du thorax, INSERM, CNRS, UNIV Nantes, Nantes, France.. Electronic address:

Background: Although a familial component of calcific aortic valve stenosis (CAVS) has been described, its heritability remains unknown. Hence, we aim to assess the heritability of CAVS and the prevalence of bicuspid aortic valve among CAVS families.

Methods: Probands were recruited following aortic valve replacement (AVR) for severe CAVS on either tricuspid (TAV) or bicuspid aortic valve (BAV). Read More

Ann Card Anaesth 2022 Apr-Jun;25(2):164-170

Department of Radiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Pulmonary regurgitation is imminent after transannular patch (TAP). We analyze the long-term performance of untreated autologous pericardium (UAP) as valve substitute at pulmonary position in patients requiring TAP.

Material And Methods: This cross-sectional study include patients operated between 2007 and 2012 (n = 92). Read More

J Am Heart Assoc 2022 Apr 12;11(8):e022339. Epub 2022 Apr 12.

Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background Intracranial aneurysms are reported in 6%-10% of patients with bicuspid aortic valve (BAV), and routine intracranial aneurysm surveillance has been advocated by some. We assessed the prevalence and features of the most important patient-outcome: aneurysmal sub-arachnoid hemorrhage (aSAH), as compared with controls without aSAH, and tricuspid aortic valve (TAV) with aSAH. Methods and Results Adult patients with accurate diagnosis of aSAH and at least one echocardiogram between 2000 and 2019 were identified from a consecutive prospectively maintained registry of aSAH admissions. Read More

Am J Cardiol 2022 May;170:76-82

Baylor Scott & White Heart and Vascular Institute; Cardiac and Thoracic Surgery, Baylor University Medical Center, Baylor Scott & White Health, Dallas, Texas.

Described herein are certain clinical and morphologic findings in 27 patients who underwent aortic valve replacement (AVR) for active infective endocarditis (IE) limited to the aortic valve. The major focus was to describe and illustrate the operatively-excised aortic valves. The aortic valves were tricuspid in 17 patients, and in each of them the infection appeared to involve a previously normal valve as evidenced by the cusps being entirely normal in areas where vegetation was not present. Read More

Heart 2022 05 12;108(11):824-826. Epub 2022 May 12.

Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

JACC Cardiovasc Interv 2022 04;15(7):e81-e83

Centre for Heart Valve Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Centre for Cardiovascular Innovation, St. Paul's and Vancouver General Hospital, Vancouver, British Columbia, Canada. Electronic address:

JACC Cardiovasc Interv 2022 04;15(7):712-724

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:

Objectives: The aim of this study was to investigate the risk of coronary obstruction during redo-transcatheter aortic valve replacement (TAVR) within a previously implanted self-expanding valve in bicuspid aortic valve (BAV) versus tricuspid aortic valve (TAV) stenosis.

Background: The prevalence of BAV in TAVR patients is expected to increase as the indication expands; however, no study has investigated the risk of coronary obstruction for future redo-TAVR in these patients.

Methods: Computed tomography (CT) simulation analysis was performed in 86 type 0 BAV, 70 type 1 BAV, and 132 TAV patients who underwent TAVR with 1 VenusA-Valve (Venus Medtech) between January 2014 and December 2019. Read More

J Am Coll Cardiol 2022 04;79(14):1352-1355

Departments of Cardiology and Cardiac Surgery, Baylor Scott and White Health, Heart Hospital Plano, Plano, Texas, USA.

J Am Coll Cardiol 2022 04;79(14):1340-1351

Centres for Heart Valve Innovation and for Cardiovascular Innovation, St Paul's and Vancouver General Hospitals, Vancouver, British Columbia, Canada; Division of Cardiology, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada; Cardiovascular Translational Laboratory, Centre for Heart Lung Innovation, University of British Columbia and St. Paul's Hospital, Vancouver, British Columbia, Canada. Electronic address:

Background: Transcatheter heart valve (THV) dysfunction with an elevated gradient or paravalvular leak (PVL) may be documented late after THV implantation. Medical management, paravalvular plugs, redo THV replacement, or surgical valve replacement may be considered. However, late balloon dilatation is rarely utilized because of concerns about safety or lack of efficacy. Read More