Search Our Scientific Publications & Authors

Am J Cardiol 2022 May 18. Epub 2022 May 18.

Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic Foundation, Cleveland, Ohio. Electronic address:

The simultaneous presence of pulmonary arterial hypertension (PAH) and secondary tricuspid regurgitation (STR) portends particularly poor outcomes. However, not all patients with PAH develop significant STR, and the mechanisms and clinical implications underlying this phenomenon remain unclear. We sought to describe the functional, anatomic, hemodynamic, and clinical characteristics of patients with PAH with and without STR. Read More

J Cardiothorac Vasc Anesth 2022 Mar 27. Epub 2022 Mar 27.

Tufts Medical Center, Department of Anesthesiology and Perioperative Medicine, Boston, MA.

Objectives: The primary aim of this study was to assess interobserver variability in grading tricuspid regurgitation (TR) severity. The authors' secondary goals were to delineate which transesophageal echocardiographic (TEE) parameters best correlate with severity and how consistent the participants were at grading severity.

Design: This was a prospective cohort study of how clinicians evaluated previously acquired TEE images and videos. Read More

Front Nutr 2022 28;9:842734. Epub 2022 Apr 28.

Department of Geriatric Intensive Medicine, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Background: The prognostic value of low-density lipoprotein cholesterol (LDL-C) in elderly patients is controversial. This study aimed to elucidate the relationship between the preoperative LDL-C and adverse outcomes in elderly patients undergoing valve replacement surgery (VRS).

Methods: A total of 2,552 aged patients (age ≥ 60 years) undergoing VRS were retrospectively recruited and divided into two groups according to LDL-C level on admission: low LDL-C (<70 mg/dL, = 205) and high LDL-C groups (≥ 70 mg/dL, = 2,347). Read More

Int J Comput Assist Radiol Surg 2022 May 19. Epub 2022 May 19.

Robarts Research Institute, 1151 Richmond St., London, ON, N6A5B7, Canada.

Purpose: Tricuspid valve (TV) interventions face the challenge of imaging the anatomy and tools because of the 'TEE-unfriendly' nature of the TV. In edge-to-edge TV repair, a core step is to position the clip perpendicular to the coaptation gap. In this study, we provide a semi-automated method to localize the VC from Doppler intracardiac echo (ICE) imaging in a tracked 3D space, thus providing a pre-mapped location of the coaptation gap to assist device positioning. Read More

PLoS One 2022 19;17(5):e0265059. Epub 2022 May 19.

Department of Cardiology, Cliniques Universitaires de Bruxelles, Hôpital Académique Erasme, Bruxelles, Belgium.

Background: Risk stratification is central to the management of pulmonary arterial hypertension (PAH). For this purpose, multiparametric tools have been developed, including the ESC/ERS risk score and its simplified versions derived from large database analysis such as the COMPERA and the French Pulmonary Hypertension Network (FPHN) registries. However, the distinction between high and intermediate-risk profiles may be difficult as the latter lacks granularity. Read More

JACC Cardiovasc Interv 2022 May 12. Epub 2022 May 12.

Complejo Hospitalario Universitario Alvaro Cunqueiro, Vigo, Spain.

Background: Severe tricuspid regurgitation (TR) is frequently associated with significant morbidity and mortality; such patients often deemed to be at high surgical risk. Heterotopic bi-caval stenting is an emerging, attractive transcatheter solution for these patients.

Objectives: To evaluate the 30-day safety and 6-month efficacy outcomes of specifically designed bioprosthetic valves for the superior and inferior vena cava. Read More

World J Cardiol 2022 Apr;14(4):239-249

Department of Physiology, Escuela Superior de Medicina, Instituto Politécnico Nacional, Ciudad de México 11340, Mexico.

Background: The estimation of left ventricular ejection fraction (LVEF) by 2D echocardiography (2D-ECHO) is the most used tool to assess LV systolic function (LVSF). Global longitudinal strain (GLS) has recently been suggested as a superior method for several evaluations. This study explored the association and prevalence of LV systolic dysfunction (LVSD) by using these methods in patients with end-stage renal disease (ESRD) and severe hyperparathyroidism (SHPTH); both associated with cardiovascular events (CEs). Read More

World J Clin Cases 2022 Apr;10(11):3547-3552

Department of Central Laboratory, Liaocheng People's Hospital, Liaocheng 252000, Shandong Province, China.

Background: Simultaneous cerebral and myocardial infarction with arterial involvement has not been reported in hypereosinophilic syndrome (HES). Here, we report a patient with HES that was also associated with acute ischemic stroke, myocardial infarction, and arterial involvement of the left common carotid artery, vertebral arteries, posterior cerebral artery, and coronary artery.

Case Summary: A 64-year-old male patient was admitted with headache and right lower extremity weakness. Read More

BMC Med Imaging 2022 May 16;22(1):91. Epub 2022 May 16.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, 100029, China.

Background: Noninvasive assessment of pulmonary artery systolic pressure by Doppler echocardiography (sPAP) has been widely adopted to screen for pulmonary hypertension (PH), but there is still a high proportion of overestimation or underestimation of sPAP. We therefore aimed to explore the accuracy and influencing factors of sPAP with right heart catheterization (RHC) as a reference.

Methods: A total of 218 highly suspected PH patients who underwent RHC and echocardiography within 7 days were included. Read More

J Card Surg 2022 May 16. Epub 2022 May 16.

Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

Congenital anomalies of the inferior vena cava are rare but if unidentified may create a risk for complications during surgery. In cardiac surgery, identifying such anomalies is crucial as they may alter the normal conduct of cardiopulmonary bypass. Herein, we describe a case of a 78-year-old women with an anomalous inferior vena cava draining into the superior vena cava, who was referred for surgical management of severe mitral regurgitation. Read More

Eur J Cardiothorac Surg 2022 May 16. Epub 2022 May 16.

Vita-Salute San Raffaele University, Department of Cardiac Surgery, IRCCS San Raffaele Hospital, Milan, Italy.

J Am Heart Assoc 2022 May 16;11(10):e025628. Epub 2022 May 16.

Department of Pediatric and Adult Congenital Cardiology University Hospital of Bordeaux Bordeaux France.

JACC Case Rep 2022 May 4;4(9):519-522. Epub 2022 May 4.

Division of Cardiology, St Michael's Hospital, University of Toronto, Ontario, Ontario, Canada.

Acute afterload mismatch and left ventricular dysfunction after mitral valve repair are well established. The impact of transcatheter tricuspid valve repair (TTVr) on right ventricular (RV) function is less clearly defined. To our knowledge, there are no reports of acute RV dysfunction after TTVr. Read More

JACC Case Rep 2022 May 4;4(9):551-555. Epub 2022 May 4.

Division of Pediatric Cardiology, Loma Linda University Children's Hospital and Medical Center, Loma Linda, California, USA.

We present the first in-human transcatheter systemic atrioventricular valve-in-valve implantation in a 37-year-old patient with Ebstein anomaly, levo-transposition of the great arteries, and prior systemic valve replacement. She had severe bioprosthetic valve regurgitation and reduced systolic function. She had high surgical risk and was planned for transcatheter intervention. Read More

Cureus 2022 Apr 13;14(4):e24119. Epub 2022 Apr 13.

Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, USA.

A 38-year-old male presented for orthotopic liver transplantation complicated by new-onset torrential tricuspid regurgitation before incision. Subclinical volume overload and functional tricuspid regurgitation created a challenging scenario in which the benefits of expeditious transplant were weighed against the risks of allograft congestion and failure. Intraoperative transesophageal echocardiography proved critical in diagnosing severe tricuspid regurgitation and guided clinical decision making. Read More

Catheter Cardiovasc Interv 2022 May;99(6):1857-1858

Division of Cardiology, Mount Sinai Hospital, New York, New York, USA.

Heart Lung 2022 May 11;55:134-139. Epub 2022 May 11.

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Währinger Gürtel 18-20, 1090 Vienna, Austria. Electronic address:

Background: Heart failure with preserved ejection fraction (HFpEF) is a major cause of morbidity and mortality. Precise risk stratification remains challenging. The one-minute sit-to-stand-test (1-min STST), a quick, objective test of functional capacity may be helpful for stratification of clinical profile in HFpEF patients. Read More

Eur Heart J 2022 May;43(19):1792-1793

Department of Cardiovascular Science, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Largo A. Gemelli 8, Rome 00168, Italy.

J Clin Med 2022 May 9;11(9). Epub 2022 May 9.

Department of Cardiology, Rabin Medical Center, Petach Tikva 4941492, Israel.

The valve-in-valve (ViV) technique is an emerging alternative for the treatment of bioprosthetic structural valve deterioration (SVD) in the tricuspid position. We report on the outcomes of patients treated by a transcatheter tricuspid valve-in-valve (TT-ViV) implantation for symptomatic SVD in the tricuspid position during the years 2010-2019 at our center. Three main outcomes were examined during the follow-up period: TT-ViV hemodynamic data per echocardiography, mortality and NYHA functional class. Read More

Heart Vessels 2022 May 13. Epub 2022 May 13.

Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

This study aimed to evaluate the efficacy of shear wave (SW) elasticity for assessing clinical outcomes in patients with significant tricuspid regurgitation (TR). Significant TR develops right heart failure (HF) with organ congestion, resulting in adverse outcomes, but appropriate therapeutic strategies remain unclear. The assessment of the degree of hepatic congestion using SW elasticity may be effective for determining therapeutic strategies. Read More

Chest 2022 May 10. Epub 2022 May 10.

Lillehei Heart Institute and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN. Electronic address:

Background: Atrial fibrillation (AF) is widely perceived to originate from the left atrium (LA). It is unclear whether increases in right ventricular (RV) afterload in older adults plays an etiological role in AF genesis independent of LA and left ventricular (LV) remodeling.

Research Question: Is higher RV afterload associated with greater AF risk independent of LA and LV remodeling?

Study Design And Methods: In this observational prospective study, we included 2246 community-dwelling older adults (mean age, 75 years) without known cardiovascular disease, with LV ejection fraction >50%, LA volume index <34 ml/m, and E/e' ratio <14 and a measurable functional tricuspid regurgitation jet velocity. Read More

Front Cardiovasc Med 2022 26;9:889163. Epub 2022 Apr 26.

Department of Cardiovascular Surgery, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Background: This study aimed to investigate the course of tricuspid annulus dilation in functional tricuspid regurgitation with varied severities by direct intraoperative assessment.

Methods: A total of 317 patients who underwent left heart surgery and concomitant tricuspid repair were divided into three groups according to the severity of the functional tricuspid regurgitation (mild, moderate and severe). Demographic and echocardiographic data were collected. Read More

Anatol J Cardiol 2022 May;26(5):414-418

Department of Cardiology, İstanbul University-Cerrahpaşa, Institute of Cardiology, İstanbul, Turkey.

EuroIntervention 2022 May 13. Epub 2022 May 13.

Heart Center Bonn, Department of Medicine II, University Hospital Bonn, Bonn, Germany.

Background: In terms of pathophysiology, tricuspid regurgitation (TR) and right ventricular (RV) function are linked to each other.

Aims: This study sought to evaluate RV-pulmonary artery (PA) coupling and its impact on clinical outcomes of TR in patients undergoing mitral transcatheter edge-to-edge repair (TEER).

Methods: We calculated RV-PA coupling ratios in patients undergoing mitral TEER from August 2010 to March 2019 by dividing the tricuspid annular plane systolic excursion (TAPSE) by the echocardiographic estimated PA systolic pressure (PASP). Read More

Cardiol Young 2022 May 12:1-4. Epub 2022 May 12.

Istanbul Medipol University Faculty of Medicine, Department of Cardiovascular Surgery, Turkey.

Congenital rupture of tricuspid chordae tendinea leading to severe tricuspid insufficiency is an extremely rare pathology associated with signs and symptoms of congestive heart failure presenting at birth. If the diagnosis and treatment of this pathology are not made early in life fetal demise may become inevitable.We herein present a neonate with central cyanosis and congestive heart failure due to rupture of an anterior leaflet chordae resulting in severe insufficiency of the tricuspid valve who was treated with appropriate surgery. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2022 Jan;47(1):94-100

Department of Cardiovascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011.

Objectives: Due to the lack of large-sized pulmonary valved conduit products in clinical practice, hand-sewn expanded polytetrafluoroethylene (ePTFE) valved conduit has been used for right ventricular outflow tract (RVOT) reconstruction in many heart centers around the world. This study aims to summarize the early results of the ePTFE valved conduit and the sewing technology of the conduit in combination with the latest progress, and to provide a reference for the application of ePTFE valved conduit.

Methods: A total of 21 patients using ePTFE valved conduit for RVOT reconstruction in the Second Xiangya Hospital, Central South University from October 2018 to October 2020 were prospectively enrolled in this study. Read More

N Engl J Med 2022 05;386(19):1862-1863

University of Michigan, Ann Arbor, MI.

N Engl J Med 2022 05;386(19):1862

Leiden University Medical Center, Leiden, the Netherlands

N Engl J Med 2022 05;386(19):1861-1862

University of Nevada, Las Vegas, Las Vegas, NV.

N Engl J Med 2022 05;386(19):1861

Yale University School of Medicine, New Haven, CT