1,948 results match your criteria Trichosporon Infections
Med Mycol Case Rep 2019 Mar 26;23:26-28. Epub 2018 Oct 26.
Brooke Army Medical Center, 3551 Roger Brooke Drive, San Antonio, TX, USA.
Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. Read More
J Lab Physicians 2018 Oct-Dec;10(4):464-470
Department of Microbiology, Jagadguru Sri Shivarathreeshwara Medical College, Mysore, Karnataka, India.
Urinary tract infections (UTIs) caused by fungi, frequently associated with medical devices, have increased and caused great morbidity and mortality among hospitalized patients. Difficulties on different species identification as well as the lack of standardized sensitivity tests , contribute to the limited information available on epidemiology, diagnosis, and therapeutics of infections. There are only sporadic reports of UTI caused by reported from India. Read More
J Lab Physicians 2018 Oct-Dec;10(4):380-386
Department of Microbiology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Background: Invasive infections due to spp. have increased recently and are frequently associated with indwelling medical devices. Such infections which are associated with biofilm formation do not respond to the routinely used antifungal agents and are often persistent, associated with high mortality rate. Read More
Zhonghua Yi Xue Za Zhi 2018 Nov;98(44):3607-3612
Department of Clinical Laboratory of the First Affiliated Hospital of Fujian Medical University, Fuzhou 350004, China.
To evaluate the performance of MALDI Biotyper system in identification of clinically isolated pathogens so as to provide a new rapid identification method. Total 21 270 pathogens strains, isolated from the First Affiliated Hospital of Fujian Medical Universityduring Nov. 2015 to Dec. Read More
J Med Microbiol 2018 Nov 27. Epub 2018 Nov 27.
National Institute of Health Dr. Ricardo Jorge - Reference Unit for Parasitic and Fungal Infections - Infectious Diseases Department, Lisbon, Portugal.
Purpose: Tissue samples from patients with suspicion of deep or subcutaneous fungal infections were analysed at the Portuguese Reference Mycology Laboratory according to a proposed diagnostic approach, which aims to constitute a rapid and accurate diagnosis for these fungal infections.
Methodology: Forty-six tissue biopsy samples were analysed over a period of 26 months, using a diagnostic approach that includes culture, panfungal PCR and Aspergillus-directed PCR.Results/Key findings. Read More
J Cutan Pathol 2018 Nov 22. Epub 2018 Nov 22.
Departments of Dermatology and Pediatrics, Columbia University Medical Center, New York, New York.
We report a case of disseminated Trichosporon asahii in a patient on systemic anti-fungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid-Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture. Read More
J Clin Microbiol 2018 Nov 21. Epub 2018 Nov 21.
Department of Clinical Laboratory, Peking Union Medical College Hospital, and Graduate School, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
One hundred and thirty-three clinical isolates were collected in the National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program (2009 to 2016). Accurate identification was performed by sequencing of the intergenic spacer (IGS) 1 region. Among these isolates (108, 81. Read More
Bioresour Technol 2018 Nov 10;273:288-296. Epub 2018 Nov 10.
Department of Civil Engineering, University of Nebraska-Lincoln, N104 SEC PO Box 886105 Lincoln, NE 68588-6105, USA.
The effect of dissolved oxygen concentration on lipid accumulation in Trichosporon oleaginosus has been investigated. The experiment was performed in 15 L fermenters. The dissolved oxygen concentration varied by adjusting the agitation and aeration. Read More
World J Microbiol Biotechnol 2018 Nov 9;34(11):173. Epub 2018 Nov 9.
Laboratoire de Biotechnologie et Microbiologie des Aliments, Unité de Formation et de Recherche en Sciences et Technologie des Aliments (UFR-STA), Université Nangui Abrogoua, 02 BP 801, Abidjan 02, Côte d'Ivoire.
Yeasts, lactic and acetic acid bacteria are responsible of microbial spoilage of alcoholic beverages. However species involved in deterioration of sorghum beer produced in Côte d'Ivoire has not been investigated. This study was carried out to identify species of yeast, LAB and AAB during spoilage of tchapalo in order to define the best strategy for beer preservative. Read More
Biotechnol Biofuels 2018 1;11:299. Epub 2018 Nov 1.
Sci-Tech Center for Clean Conversion and High-valued Utilization of Biomass, Jilin Province, Northeast Electric Power University, Jilin, 132012 China.
Background: The release of refined soybean oil wastewater (RSOW) with a high chemical oxygen demand (COD) and oil content burdens the environment. The conversion of RSOW into lipids by oleaginous yeasts may be a good way to turn this waste into usable products.
Results: The oleaginous yeast was used for treating the RSOW without sterilization, dilution, or nutrient supplementation. Read More
Vector Borne Zoonotic Dis 2018 Nov 1. Epub 2018 Nov 1.
2 Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, University of Sadat City , Sadat City, Egypt .
As human populaces develop, they are progressively squeezed into higher living densities. The same is true for horticulture and animals expected to bolster these communities. Despite the high potential for zoonotic transmission, connections among humans and cattle have been understudied; however, Candida albicans remains the most important medical mycosis. Read More
Diagn Microbiol Infect Dis 2018 Sep 21. Epub 2018 Sep 21.
Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:
Identification of opportunistic yeasts in developing countries is mainly performed by phenotypic assays, which are time-consuming and prone to errors. Wrong species identification may result in suboptimal treatment and inaccurate epidemiological data. To improve rapidity and accuracy of species identification, a diagnostic strategy using a stepwise "YEAST PANEL multiplex PCR assays" targeting 21 clinically important yeast species of Candida, Trichosporon, Rhodotorula, Cryptococcus, and Geotrichum was designed. Read More
Ophthalmol Retina 2018 Jul 21;2(7):746-748. Epub 2018 Mar 21.
Edward S. Harkness Eye Institute, Department of Ophthalmology, Columbia University Medical Center, 635 West 165 Street, New York, New York, 10032.
Infect Drug Resist 2018 9;11:1659-1667. Epub 2018 Oct 9.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China,
Purpose: In this study, we report results from a 5-year surveillance for noncandidal yeast species causing invasive infections from 65 hospitals in China.
Materials And Methods: Species identification was carried out by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) supplemented by rDNA sequencing, and fluconazole and voriconazole susceptibilities of yeasts were determined by Clinical and Laboratory Standards Institute (CLSI) disk diffusion methods.
Results: Overall, 884 noncandidal isolates belonging to 38 species were collected. Read More
Int J Food Microbiol 2018 Oct 13;290:170-179. Epub 2018 Oct 13.
Laboratory of Food Microbiology and Hygiene, Department of Food Science and Nutrition, College of Home Economics, Alonso Hall, A. Ma. Regidor Street, University of the Philippines Diliman, 1101 Quezon City, Philippines. Electronic address:
The ultraviolet-C (UV-C) decimal reduction energy (D) values of 17 spoilage yeasts and their composited inoculum were determined in coconut liquid endosperm (pH 5.26, 5.8 °Brix, 0. Read More
Avian Dis 2018 Sep;62(3):286-290
B Department of Epizootiology with Clinic of Bird and Exotic Animals, Wroclaw University of Environmental and Life Sciences, pl. Grunwaldzki, 45 50-366 Wrocław, Poland.
This study was undertaken to explore the issue of yeast species prevalence in colonizing the gastrointestinal tract of healthy turkeys. The samples were collected from the beak cavity, crop, and cloaca of 5-wk-old turkeys, cultured and classified using morphological, biochemical, and genetic analysis based on ITS1-5.8rRNA-ITS2 fragment sequencing. Read More
Curr Med Mycol 2018 Jun;4(2):14-20
Department of Pathology and Laboratory Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Background And Purpose: Candidemia is one of the most important fungal infections caused by species. Infections and mortality caused by species have been on a growing trend during the past two decades. The resistance of yeasts to antifungal drugs and their epidemiological issues have highlighted the importance of accurately distinguishing the yeasts at the species level. Read More
Ann Parasitol 2018 ;64(3):199-202
Department of Microbiology and Mycology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, ul. Oczapowskiego 1A, 10-917 Olsztyn, Poland
This paper concerns the determination of the share of fungi of the Saccharomyces genus in the mycobiota of the gastrointestinal tract of patients with colorectal cancer. The biological material were fungi isolated from the mouth, oesophagus, duodenum, stomach, large intestine and anus of 92 patients with colorectal cancer. They were subjected to standard mycological diagnostic testing. Read More
Mycoses 2018 Oct 11. Epub 2018 Oct 11.
Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Background: Emergence of highly inflammatory genital dermatophyte infections has been reported from Southeast Asia. In view of this, knowledge of the non-outbreak fungal flora of the genitals is required as a baseline study.
Objectives: We present our 12-year experience in a tertiary clinic with the diagnosis of scrotal fungal infections. Read More
3 Biotech 2018 Oct 5;8(10):440. Epub 2018 Oct 5.
1PROIMI-CONICET (Planta Piloto de Procesos Industriales Microbiológicos), Av. Belgrano y Caseros (T4001MVB), Tucuman, Argentina.
HP-2023 completely discolorised Reactive Black 5 (200 mg/l) in 24 h. Manganese peroxidase and phenoloxidase, but no laccase activities were detected throughout the incubation. Total aromatic amines in media with Reactive Black 5 decreased 83% after 24 h, supporting an oxidative mechanism of azo dye discoloration. Read More
J Dermatol 2018 Oct 8. Epub 2018 Oct 8.
Department of Dermatology, School of Medicine and University Hospital Dr Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.
Infect Drug Resist 2018 20;11:1537-1547. Epub 2018 Sep 20.
Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China,
Background: is a rare fungal species that has not been described in human invasive infections.
Patients And Methods: In this study, we investigated two isolates from patients with invasive infections in two hospitals in China, as part of the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program. Both patients were under immunocompromised conditions. Read More
Fungal Genet Biol 2018 Dec 27;121:46-55. Epub 2018 Sep 27.
Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil. Electronic address:
Trichosporon asahii shares with Cryptococcus species the ability to produce glucuronoxylomannan (GXM), an immunomodulatory fungal polysaccharide. The ability of other opportunistic species of Trichosporon to produce GXM-like polysaccharides is unknown. In this study, we observed that T. Read More
J Fish Dis 2018 Nov 26;41(11):1719-1732. Epub 2018 Sep 26.
Botany and Microbiology Department, Faculty of Science, Assiut University, Assiut, Egypt.
One hundred and twenty-nine isolates of Trichosporon jirovecii were isolated from the melanized exoskeleton as well as eyestalks, gills, muscle and haemolymph of red swamp crayfish (Procambarus clarkii) collected from the River Nile, during summer 2015. Isolates were similar morphologically, biochemically and genetically. Also, random amplified polymorphic DNA (RAPD) analysis exhibited no polymorphism among the tested isolates. Read More
Mycoses 2018 Sep 19. Epub 2018 Sep 19.
Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan.
Background: Current guidelines recommend echinocandins as first-line therapy for candidemia. However, several non-Candida yeast are non-susceptible to echinocandins (echinocandin non-susceptible yeast, ENSY), including Cryptococcus, Geotrichum, Malassezia, Pseudozyma, Rhodotorula, Saprochaete, Sporobolomyces and Trichosporon. In laboratories that are not equipped with rapid diagnostic tools, it often takes several days to identify yeast, and this may lead to inappropriate presumptive use of echinocandins in patients with ENSY fungemia. Read More
BMC Infect Dis 2018 Sep 18;18(1):470. Epub 2018 Sep 18.
Centro de Ciências da Saúde, Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Faria S/N, Petrópolis, Natal, Rio Grande do Norte, Brazil.
Background: Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Read More
Med Mycol 2018 Sep 12. Epub 2018 Sep 12.
Department of Microbial Science and Host Defense, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.
Trichosporon asahii is a human fungal pathogen that causes deep-seated infections in immunocompromised patients. While the pathogenic mechanisms of T. asahii remain unknown, our previous studies indicate that adherent colony morphologies were generated from parent strains, which may contribute to their pathogenicity. Read More
Indian J Dermatol 2018 Sep-Oct;63(5):386-390
Department of Dermatology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.
Context: Acne vulgaris is a disorder showing persistent inflammation in the pilosebaceous follicles. It is one of the most prevalent dermatoses that millions of people suffer from globally.
Aim: The aim of this study was to identify species from patients with acne and to determine their drugs susceptibility. Read More
Int J Biol Macromol 2018 Dec 25;120(Pt A):537-546. Epub 2018 Aug 25.
Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi 110021, India. Electronic address:
Phospholipases are hydrolytic enzymes that play crucial roles in vivo and also possess immense biotechnological potential. In the present study, the phospholipase B of Trichosporon asahii MSR54 was overexpressed in E. coli and characterized. Read More
J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618795268. Epub 2018 Aug 21.
Kern Medical-University of California Los Angeles, Bakersfield, CA, USA.
is a rare cause of fungal infection in immunocompromised patients, mainly seen in hematological malignancies. infections are extremely rare in immunocompetent patients, as it is part of normal human microbial flora. We are presenting an extremely rare case of peritonitis in an otherwise immunocompetent patient who suffered from gastrointestinal leakage due to pancreatitis. Read More
Arerugi 2018;67(7):948-953
Itabashi Chuo Medical Center.
A 53-year-old-woman presented our hospital with 1 month history of exertional dyspnea and mild fever. When examined, temperature was 37.2℃ and her respiratory rate of 22/min with an O2 saturation of 95% (02 4L/min), the rest of her vital signs were normal. Read More
Microbes Environ 2018 Sep 24;33(3):290-300. Epub 2018 Aug 24.
Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences.
The present study aimed to reveal the eukaryotic diets of two economically important marine sediment-inhabiting worms, Sipunculus nudus (peanut worm) and Urechis unicinctus (spoon worm), using clone libraries and phylogenetic analyses of 18S rRNA genes. Fungal rDNA was also targeted and analyzed to reveal mycobiomes. Overall, we detected a wide range of eukaryotic phylotypes associated with the larvae of S. Read More
Int J Hyg Environ Health 2018 Sep 23;221(8):1107-1115. Epub 2018 Aug 23.
National Institute for Public Health and the Environment, Centre for Zoonoses and Environmental Microbiology, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.
Possible transmission pathways of fungi in indoor swimming pool facilities were assessed through fungal counting in different areas of the facilities and typing of the collected fungal isolates. Air, water and surface samples were collected from seven different indoor swimming pool facilities. Fungal species were identified based on their internal transcribed spacer (ITS) sequences. Read More
Br J Dermatol 2018 Aug 16. Epub 2018 Aug 16.
Laboratory of Dermatoimmunology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Deficiency of CARD9 (caspase recruitment domain-containing protein 9) has been reported in individuals with recurrent and invasive fungal infections. We report on a patient who first had Trichosporon asahii affecting the skin then Candida albicans infections involving the digestive tract and knee joint, along with elevated serum IgE. After stimulation with C. Read More
Medchemcomm 2017 Dec 17;8(12):2258-2262. Epub 2017 Oct 17.
Departamento de Química Orgánica , Facultad de Química , Universidad Autónoma del Estado de México , Paseo Colón/Paseo Tollocan s/n , Toluca , Estado de México 50120 , Mexico . Email: ; ; Tel: +52 722 217 5109x113.
Novel oxazolidin-2-one-linked 1,2,3-triazole derivatives () were synthesized by straightforward and versatile azide-enolate (3 + 2) cycloaddition. The series of compounds was screened for antifungal activity against four filamentous fungi as well as six yeast species of spp. According to their efficiency and breadth of scope, they can be ordered as > > > , especially in relation to the activity displayed against ATCC-34138, ATCC-28592 and ATCC-8690, compounds , and showed excellent activity against (MIC 0. Read More
Med Mycol 2018 Aug 4. Epub 2018 Aug 4.
Laboratório de Microbiologia, Faculdade de Medicina de São José do Rio Preto, 5416 Brigadeiro Faria Lima Ave., 15090-000, São José do Rio Preto, Brazil.
The objectives of this study were to identify yeasts in 40 feces samples of Agapornis birds and determine their antifungal susceptibility profile by two methodologies. Results indicated 92.5% of positivity (46 isolates). Read More
Folia Microbiol (Praha) 2018 Jul 30. Epub 2018 Jul 30.
Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28, Prague, Czech Republic.
Microorganisms that cause chronic infections exist predominantly as surface-attached stable communities known as biofilms. Microbial cells in biofilms are highly resistant to conventional antibiotics and other forms of antimicrobial treatment; therefore, modern medicine tries to develop new drugs that exhibit anti-biofilm activity. We investigated the influence of a plant polyphenolic compound resveratrol (representative of the stilbene family) on the opportunistic pathogen Trichosporon cutaneum. Read More
J Econ Entomol 2018 Sep;111(5):2081-2088
Department of Biology, University of Texas Rio Grande Valley, Edinburg, TX.
Yeasts from all immature life stages of Mexican fruit fly Anastrepha ludens (Loew) (Diptera: Tephritidae) from diet, insectary air, and rearing materials were isolated, identified and evaluated for pathogenicity. Fifteen species of yeasts with one to genus level were identified from 72 yeast cultures obtained. Zygosaccharomyces bailii was the only yeast found to be highly pathogenic to Mexican fruit fly. Read More
J Mycol Med 2018 Sep 6;28(3):452-456. Epub 2018 Jul 6.
Public Health Agency of Turkey, National Molecular Microbiology Reference Centers Laboratory, Türkiye Halk Sağlığı Kurumu, Moleküler Mikrobiyoloji Referans Laboratuvarları, Adnan Saygun Cad. No: 55 Sıhhiye, Ankara, Turkey.
Introduction: Trichosporon asahii is the most common species that causes trichosporonosis.
Materials And Methods: In the present study, a collection of 68T. asahii strains recovered from hospitalized patients urine samples between 2011 and 2016 was examined. Read More
Front Microbiol 2018 21;9:1337. Epub 2018 Jun 21.
VTT Technical Research Centre of Finland Ltd., Espoo, Finland.
Mitochondrial pyruvate dehydrogenase (PDH) is important in the production of lipids in oleaginous yeast, but other yeast may bypass the mitochondria (PDH bypass), converting pyruvate in the cytosol to acetaldehyde, then acetate and acetyl CoA which is further converted to lipids. Using a metabolic model based on the oleaginous yeast , we found that introduction of this bypass to an oleaginous yeast should result in enhanced yield of triacylglycerol (TAG) on substrate. (formerly ) is an oleaginous yeast which can produce TAGs from both glucose and xylose. Read More
PLoS One 2018 3;13(7):e0200160. Epub 2018 Jul 3.
Institute of Molecular Physiology and Biotechnology of Plants (IMBIO), University of Bonn, Bonn, Germany.
Land plants are engaged in intricate communities with soil bacteria and fungi indispensable for plant survival and growth. The plant-microbial interactions are largely governed by specific metabolites. We employed a combination of lipid-fingerprinting, enzyme activity assays, high-throughput DNA sequencing and isolation of cultivable microorganisms to uncover the dynamics of the bacterial and fungal community structures in the soil after exposure to isothiocyanates (ITC) obtained from rapeseed glucosinolates. Read More
Infect Chemother 2018 Jun;50(2):138-143
Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Because primary antifungal prophylaxis is widely used for immunocompromised hosts, the incidences of unusual fungal infections have increased. Trichosporon asahii has emerged as an important life-threatening opportunistic systemic pathogen because of the increased use of cytotoxic or immunosuppressant agents, along with high mortality rates. Here, we describe a case of catheter-related T. Read More
Huan Jing Ke Xue 2017 Jun;38(6):2477-2485
Xi'an Water Group Company Limited, Xi'an 710061, China.
To illustrate the species and characteristics of filamentous microorganisms in bulking sludge, culture method, microscopic examination and molecular biological analysis were conducted to isolate and identify the filamentous microorganisms existing in bulking sludge collected from municipal wastewater treatment plant. Filamentous microorganisms isolated by Gause's synthetic agar medium and starch agar fell into 18 genera, among which and belong to bacterial phylum Actinobacteria, all other isolates were classified into fungi. and were the fungi with high occurrence frequency in culture medium. Read More
Huan Jing Ke Xue 2018 Feb;39(2):880-888
Fujian Key University Laboratory of Estuarine Ecological Security and Environmental Health, School of Environmental Science and Engineering of Xiamen University TanKah Kee College, Zhangzhou 363105, China.
The relationship between microbial populations and sludge filtration performance was studied when active sludge was used to treat the leachate from municipal solid waste incineration plants. Two SBRs (SBR1 and SBR2) were operated at the same conditions, except that SBR1 was exposed to the sunlight and SBR2 was in the dark. To identify the difference in microbial populations in two reactors, high-throughput sequencing method was used. Read More
Huan Jing Ke Xue 2018 Jul;39(7):3279-3285
College of Resources and Environmental Science, Xinjiang University, Urumqi 830046, China.
Samples were collected from a sequencing batch reactor (SBR) to characterize the similarities and differences in microbial community composition in samples using Illumina high-throughput sequencing. The main objective of this study was to characterize changes in microbial community composition during filamentous sludge bulking and control processes. The SBR working volume was 11 L, and the reactors were operated for 399 days in total. Read More
J Biotechnol 2018 Sep 18;281:81-86. Epub 2018 Jun 18.
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address:
Lignin is one of the major components of lignocellulose biomass and chemically degrades into phenolic aldehydes including 4-hydroxybenzaldehyde, vanillin, and syringaldehyde. No lipid accumulation from the phenolic aldehydes by oleaginous microbes had been succeeded. Compared with vanillin and syringaldehyde, T. Read More
AAPS PharmSciTech 2018 Jun 18. Epub 2018 Jun 18.
Graduate Program in Pharmaceutical Sciences, Dispersed Systems Laboratory (LaSid), Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Faria, S/N, Natal, RN, 59012-570, Brazil.
Amphotericin B (AmB), a potent antifungal drug, presents physicochemical characteristics that impair the development of suitable dosage forms. In order to overcome the AmB insolubility, several lipid carriers such as microemulsions have been developed. In this context, the bullfrog oil stands out as an eligible oily phase component, since its cholesterol composition may favor the AmB incorporation. Read More
J Biotechnol 2018 Sep 21;281:74-80. Epub 2018 Jun 21.
Department of Pharmaceutics, College of Chemical Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, China. Electronic address:
A novel method to synthesize poly(ε-caprolactone) (PCL) through a three-step, lipase-mediated chemo-enzymatic reaction from cyclohexanone using an immobilized lipase from Trichosporon laibacchii (T. laibacchii) CBS5791 was developed. The immobilized preparation with 1280 U· g used here was obtained by a method of purification and in situ immobilization where the crude intracellular lipase (cell homogenate) was subjected to partial purification by an aqueous two-phase system (ATPS) consisting of 12% (w/w) polyethylene glycol (PEG) 4000 and 13% (w/w) potassium phosphate (KHPO) and then in situ immobilization directly on diatomite from the top PEG-rich phase of ATPS. Read More
Mol Plant Microbe Interact 2018 Dec 3;31(12):1257-1270. Epub 2018 Oct 3.
1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan; and.
Plant viruses cause devastating diseases in plants, yet no effective viricide is available for agricultural application. We screened cultured filtrates derived from various soil microorganisms cultured in vegetable broth that enhanced plant viral resistance. A cultured filtrate, designated F8 culture filtrate, derived from a fungus belonging to the genus Trichosporon, induced strong resistance to various viruses on different plants. Read More
Neurobiol Dis 2018 Sep 1;117:42-61. Epub 2018 Jun 1.
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera, 1. Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Electronic address:
Multiple sclerosis (MS) is the prototypical inflammatory disease of the central nervous system (CNS), leading to multifocal demyelination and neurodegeneration. The etiology of this incurable disease is unknown and remains a matter of intensive research. The possibility that microbial infections, such as viruses or bacteria, can trigger an autoimmune reaction in CNS tissue has been suggested. Read More