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Mycopathologia 2022 Jun 4. Epub 2022 Jun 4.

Laboratory of Mycology, Faculty of Medicine, Federal University of Rio Grande, Rio Grande, Rio Grande Do Sul, 96200-400, Brazil.

Opportunistic infections are serious complications in critically ill COVID-19 patients, especially co-infections with bacterial and fungal agents. Here we report a rare case of bloodstream co-infection by Trichosporon asahii, an emerging yeast, and Acinetobacterbaumannii, an opportunistic nosocomial pathogen, both multidrug resistant, in a tertiary hospital from southern Brazil. A review of the literature regarding similar cases is also included. Read More

Pathogens 2022 May 20;11(5). Epub 2022 May 20.

Laboratoire de Parasitologie-Mycologie, IHU Méditerranée Infection, 13385 Marseille, France.

Invasive infections due to spp. are life-threatening opportunistic fungal infections that may affect a wide array of organs. Here, we described a case of pericardial effusion due to   in a 42-year-old female after a heart transplantation. Read More

Front Microbiol 2022 25;13:876611. Epub 2022 Apr 25.

Laboratório de Micologia, Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Melanin is one of the most studied virulence factors in pathogenic fungi. This pigment protects them from a series of both environmental and host stressors. Among basidiomycetes, and are known to produce melanin in the presence of phenolic precursors. Read More

Ann Parasitol 2022 ;68(1):169-175

Faculty of Medical Technology-Benghazi, Ministry of Technical and Vocational Education, Al-Fuwayhat, Benghazi, Libya.

Antifungal resistance represents a major clinical challenge to clinicians responsible for treating invasive fungal infections due to the limited arsenal of systemically available antifungal agents. Currently, fungal invasive infections are related to antifungal resistance by pathogenic fungi. The current study assumed to use of natural ingredients such as the fruiting bodies of large fungi, specifically Agaricus gennadii. Read More

Curr Pharm Biotechnol 2022 Apr 11. Epub 2022 Apr 11.

Department of Pharmaceutics, School of Pharmaceutical Sciences, Delhi Pharmaceutical Sciences and Research University, New Delhi, India.

Background- The treatment of wound associated infections has always remained a challenge for clinicians with the major deterring factor being microbial biofilms, majorly bacterial or fungal. Biofilm infections are becoming a global concern owing to resistance against antimicrobials. Fungal biofilms are formed by a wide variety of fungal pathogens namely Candida sp. Read More

Braz J Microbiol 2022 Apr 5. Epub 2022 Apr 5.

Center for Research in Medical Mycology, Department of Pathology, Federal University of Espírito Santo (UFES), Av. Marechal Campos, 1468, Vitoria, ES, 29040-090, Brazil.

Trichosporon spp. are a constituent of the normal flora of humans that can cause both superficial and invasive infections, mainly in immunocompromised and immunocompetent hosts, respectively. Herein, we a report of Trichosporon asahii causing subcutaneous fungal infection (SFI) in an immunocompetent patient after carpal tunnel surgery. Read More

Med Mycol 2022 Apr;60(4)

Division of Clinical Microbiology, Department of Laboratory Medicine, West China Hospital Sichuan University, Chengdu, Sichuan, 610041, China.

Cryptococcus is an opportunistic pathogenic fungus and is the major cause of fungal meningitis. The cryptococcal antigen (CrAg) lateral flow assay (LFA) is an immunochromatographic test system that has simplified diagnosis as a point-of-care test. In this study, we evaluated the diagnostic performance of Cryptococcal capsular polysaccharide detection FungiXpert (Genobio Pharmaceutical, Tianjin, China) using serum and cerebrospinal fluid (CSF) samples for the diagnosis of cryptococcosis and investigated the cross-reaction of the assays to pathogenic fungi and bacterium by comparing it to the U. Read More

J Antimicrob Chemother 2022 05;77(6):1779-1784

University of Cologne, Faculty of Medicine and University Hospital Cologne, Department I of Internal Medicine, Excellence Center for Medical Mycology (ECMM), Cologne, NRW, Germany.

Background: Invasive infections due to Trichosporon spp. are life-threatening opportunistic fungal infections that require complex clinical management. Guidelines assist clinicians but can be challenging to comply with. Read More

Proc (Bayl Univ Med Cent) 2022 15;35(2):195-196. Epub 2021 Nov 15.

Department of Hospital Medicine, CHI Health Bergan Mercy Hospital, Omaha, Nebraska.

Fungal infections have been drastically increasing in incidence in recent years, preferentially affecting immunocompromised hosts and causing potentially fatal outcomes. One of the emerging fatal fungal pathogens is , a non-Candida yeast that has been increasingly reported in recent years. Previous literature has described as primarily affecting immunocompromised hosts, specifically those who are neutropenic, and causing fatal disseminated infections. Read More

Med Mycol Case Rep 2022 Jun 21;36:10-12. Epub 2022 Feb 21.

University of Manitoba, Max Rady College of Medicine, Winnipeg, Manitoba, Canada.

A 63-year-old male with mechanical aortic valve replacement presents with Trichosporon mucoides endocarditis. Eosinophilia was noted, which has recently been described in invasive trichosporonosis. He was treated successfully with combination voriconazole and terbinafine therapy. Read More

Pathogens 2022 Feb 12;11(2). Epub 2022 Feb 12.

Infectious Diseases Unit, 3rd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Hippokration General Hospital, 54642 Thessaloniki, Greece.

(1) Background: species have emerged as important opportunistic fungal pathogens, with being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trichosporonosis in neonates and pediatric patients with malignancies or hematologic disorders. We reviewed case reports and case series of trichosporonosis due to published since 1994, the year of the revised taxonomic classification. Read More

J Pediatr Hematol Oncol 2022 Mar;44(2):e514-e517

Department of Pediatric Hematology/Oncology, Stanford University School of Medicine, Stanford, CA.

Invasive fungal disease is a difficult to diagnose complication of therapy in patients with hematologic malignancy. Antifungal prophylaxis is recommended in high-risk populations, but its use in other populations is less clear. This brief report describes a patient with Trisomy 21 on caspofungin prophylaxis who died of disseminated Trichosporon asahii during induction therapy for new diagnosis low-risk B-cell acute lymphoblastic leukemia, accompanied by a review of similar cases in the literature. Read More

Front Cell Infect Microbiol 2022 4;12:834015. Epub 2022 Feb 4.

The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Over the past decade, has been recognized globally as a source of opportunistic infections. It is a yeast-like fungus, and its association as an uncommon pulmonary pathogen with cystic fibrosis patients has been previously reported. Immunocompromised patients are at the highest risk of infections. Read More

Arerugi 2022 ;71(1):42-45

Department of Respiratory Medicine, Hiroshima University Hospital.

A 70-year-old woman undergoing long-term treatment for systemic scleroderma and secondary Sjögren syndrome developed fever during tapering of steroids. Chest CT showed centrilobular granular shadow and ground glass opacities. The pathology of transbronchial lung biopsy and the findings of bronchoalveolar lavage fluid were consistent with hypersensitivity pneumonitis and positive for anti-Trichosporon asahii antibody. Read More

Sci Rep 2022 02 14;12(1):2421. Epub 2022 Feb 14.

Department of Biology, Faculty of Applied Science, Umm Al-Qura University, Makkah, Saudi Arabia.

Biosynthesis of silver nanoparticles (AgNPs) is emerging as a simple and eco-friendly alternative to conventional chemical synthesis methods. The role of AgNPs is expanding as antimicrobial and anticancer agents, sensors, nanoelectronic devices, and imaging contrast agents. In this study, biogenic AgNPs were synthesized using extracts of different marine algae species, including Ulva rigida (green alga), Cystoseira myrica (brown alga), and Gracilaria foliifera (red alga), as reducing and capping agents. Read More

Infez Med 2021 10;29(3):464-468. Epub 2021 Sep 10.

Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Acute-on-chronic liver failure (ACLF) is often associated with a dismal outcome. Infections might preclude access to liver transplantation (LT) for these patients, further reducing their chance of survival. We report the case of a patient with ACLF who died before LT for biofilm-producing fungemia. Read More

Infect Drug Resist 2022 2;15:321-333. Epub 2022 Feb 2.

Department of Oncology, the First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People's Republic of China.

Objective: Since the nosocomial fungal infections increasingly emerge, we extensively investigated the fungal species stratification and antifungal sensitivity profiles, clinical characteristics and associated risk factors of immunosuppressed patients with clinically diagnosed invasive fungal infections (IFIs) in a tertiary hospital of Anhui province.

Methods: In total, 112 subjects with immunosuppressive state were enrolled from a comprehensive tertiary hospital in Central China between July 2019 and December 2021. Eight-one fungal isolates were clinically recovered by fungus-culturing approaches. Read More

Am J Med 2022 May 5;135(5):e104-e105. Epub 2022 Feb 5.

Department of General Internal Medicine, Tokyo Metropolitan Tama Medical Center, Japan; Department of Respiratory Medicine, Tokyo Metropolitan Tama Medical Center, Japan.

Front Cell Infect Microbiol 2021 7;11:805514. Epub 2022 Jan 7.

Department of Medical Sciences, Division of Infectious Diseases, Azienda Ospedaliera Universitaria (A.O.U.) Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.

Background: Allogeneic hematopoietic stem cell transplant (allo-HSCT) recipients are exposed to an increased risk of invasive fungal infections (IFIs) due to neutropenia, immunosuppressive treatments, graft-versus-host disease (GvHD) and incomplete immune reconstitution. Although clinical benefit from antifungal prophylaxis has been demonstrated, IFIs remain a leading cause of morbidity and mortality in these patients. In the last decades, attention has also been focused on potential risk factors for IFI to tailor an antifungal prevention strategy based on risk stratification. Read More

Med Mycol Case Rep 2022 Mar 14;35:15-17. Epub 2021 Dec 14.

American University of Antigua College of Medicine, Antigua and Barbuda.

Trichosporon colonizes the skin, vagina, gastrointestinal and respiratory tract of humans. Superficial infections are common, while disseminated trichosporonosis is rare, specifically seen among immunocompromised patients and often associated with high mortality. We report a rare case Trichosporon asahii infection in a 78-year-old diabetic, with associated acute interstitial glomerulonephritis. Read More

Access Microbiol 2021 3;3(12):000285. Epub 2021 Dec 3.

Institute for Medical Microbiology and Hospital Hygiene, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Rare invasive fungal infections are increasingly emerging in hosts with predisposing factors such as immunodeficiency. Their timely diagnosis remains difficult, as their clinical picture may initially mimic infections with more common fungal species and species identification may be difficult with routine methods or may require time-consuming subcultures. This often results in ineffective drug administration and fatal outcomes. Read More

Ophthalmology 2022 01;129(1):66

IRCCS - Fondazione Bietti, Rome, Italy.

Case Rep Infect Dis 2021 17;2021:6841393. Epub 2021 Dec 17.

Wellstar Atlanta Medical Center Family Med Residency Program, 1000 Corporate Center Drive, Suite 200, Morrow 30260, GA, USA.

is a yeast-like basidiomycete that is an emerging opportunistic infection in immunocompromised patients. Urinary tract infections due to are rarely reported in the literature and typically seen only in immunocompromised patients. In addition to being immunocompromised, critically ill COVID-19 patients often have prolonged exposure to antibiotics, corticosteroids, and Foley catheters, which further increases their susceptibility to infection with There are limited case reports documenting successful treatment of among hospitalized patients, particularly among COVID-19 patients, in the literature. Read More

Future Microbiol 2022 01 16;17:81-87. Epub 2021 Dec 16.

Federal University of Pernambuco, Recife, Pernambuco, 50670-901, Brazil.

species are emerging as opportunistic pathogens that mainly affect immunocompromised patients. Patients with onco-hematological diseases usually present with fungemia by species, especially by . Reports of this infection by other species of the genus are uncommon. Read More

J Mycol Med 2022 Mar 21;32(1):101229. Epub 2021 Nov 21.

Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey.

Background: Invasive Trichosporon infections are rarely seen opportunistic fungal infections in children and mainly affect immunocompromised patients. This multicenter retrospective study has rewieved the characteristics, risk factors, treatment modalities and outcomes of bloodstream infections caused by Trichosporon species in children diagnosed over the past ten years in Turkey.

Methods: The study was performed with the participation of 12 of 55 hospitals invited from Turkey. Read More

BMC Infect Dis 2021 Dec 7;21(1):1229. Epub 2021 Dec 7.

Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.

Background: Trichosporon asahii is an opportunistic fungus that causes infections in immunosuppressed patients. It is rarely seen in children and immunocompetent hosts. The mortality rates are still high despite early treatment with proper antifungal drugs. Read More

Biomolecules 2021 11 19;11(11). Epub 2021 Nov 19.

Department of Biotechnology, University of Chemistry and Technology, Technická 5, 166 28 Prague, Czech Republic.

Microbial biofilms formed by pathogenic and antibiotic-resistant microorganisms represent a serious threat for public health in medicine and many industrial branches. Biofilms are involved in many persistent and chronic infections, the biofouling of water and food contamination. Therefore, current research is involved in the development of new treatment strategies. Read More

Pediatr Infect Dis J 2022 04;41(4):352-357

From the Division of Neonatology, Department of Neonatology, Children's Hospital, University of Cologne, Cologne, Germany.

Background: Extreme immature infants are at an increased risk of fungal infection due to immaturity of the skin barrier and the immune system. Besides Candida infections, in particular, Aspergillus may cause life-threatening diseases in preterm infants. Frequently, Aspergillus primarily affects the skin and may cause extensive damage. Read More

Future Microbiol 2021 11 25;16:1277-1288. Epub 2021 Oct 25.

Departament of Clinical Analyses and Biomedicine, Universidade Estadual de Maringá, Maringá, Paraná, CEP, 87020-900, Brazil.

Trichosporonosis infections have been increasing worldwide. Providing adequate treatment for these infections remains a challenge. This scoping review contains information about potential antifungals to treat this pathology. Read More

Cureus 2021 Aug 21;13(8):e17345. Epub 2021 Aug 21.

Clinical Microbiology, Government Medical College & Hospital, Chandigarh, Chandigarh, IND.

species are basidiomycetous yeast-like organisms found ubiquitous in nature. They are increasingly been recognized as opportunistic pathogens capable of causing life-threatening invasive diseases (trichosporonosis), especially in immuno-suppressed patients and rarely in immuno-competent patients too. Earlier multiple members of the genus were clubbed together as but after the advent of molecular techniques, more than 50 different subspecies and around 16 different strains causing human diseases are reported. Read More