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Front Cell Infect Microbiol 2021 22;11:645812. Epub 2021 Apr 22.

Faculty of Medicine, Federal University of Ceará, Fortaleza, Brazil.

Persister cells are metabolically inactive dormant cells that lie within microbial biofilms. They are phenotypic variants highly tolerant to antimicrobials and, therefore, associated with recalcitrant infections. In the present study, we investigated if and are able to produce persister cells. Read More

Pathogens 2021 Apr 30;10(5). Epub 2021 Apr 30.

Department of Epizootiology and Clinic of Bird and Exotic Animals, Wroclaw University of Environmental and Life Sciences, 50-366 Wrocław, Poland.

The microbiota of the gastrointestinal tract of humans and animals is inhabited by a diverse community of bacteria, fungi, protozoa, and viruses. In cases where there is an imbalance in the normal microflora or an immunosuppression on the part of the host, these opportunistic microorganisms can cause severe infections. The study presented here evaluates the biochemical and antifungal susceptibility features of spp. Read More

J Fungi (Basel) 2021 Apr 24;7(5). Epub 2021 Apr 24.

Intensive Care Medicine Department, Lapeyronie Hospital, Montpellier University Hospital, 371, Avenue du Doyen Gaston Giraud, 34090 Montpellier, France.

Comprehensive data on emerging invasive fungal infections (EIFIs) in the critically ill are scarce. We conducted a case-control study to characterize EIFIs in patients admitted to a French medical ICU teaching hospital from 2006 to 2019. Among 6900 patients, 26 (4 per 1000) had an EIFI: accounted for half, and other isolates were mainly , and . Read More

Mycopathologia 2021 Apr 20. Epub 2021 Apr 20.

Department of Dermatology, The Seventh Medical Center of PLA General Hospital, Beijing, 100700, China.

Trichosporon asahii (T. asahii) is a clinically important opportunistic pathogenic fungus capable of causing systemic lethal infection in immunosuppressive and immunodeficient hosts. However, the mechanism of the host immune response upon T. Read More

Rev Iberoam Micol 2021 Apr 7. Epub 2021 Apr 7.

Unidad de Investigación, Hospital Regional de Alta Especialidad de Ixtapaluca, Ixtapaluca, Edo. Méx., Mexico. Electronic address:

Background: The molecular reclassification of the order Trichosporonales placed the medically relevant Trichosporon species into three genera of the family Trichosporonaceae: Cutaneotrichosporon, Trichosporon, and Apiotrichum. From the clinical and epidemiological standpoint, it is important to identify any species of the family Trichosporonaceae because they present different antifungal susceptibility profiles. In Mexico, little is known about trichosporonosis etiology because the fungi are identified through phenotypic methods. Read More

Rev Port Cardiol 2021 Apr 19;40(4):305.e1-305.e3. Epub 2021 Mar 19.

Departamento de Medicina Interna, Escola de Medicina e Cirurgia, Universidade Federal do Rio de Janeiro, Rio Janeiro, RJ, Brasil.

Trichosporon beigelii is a non-pathogenic fungus that can however become an opportunist agent of disseminating and potentially fatal infections, especially in immunocompromised patients. In the literature, there are only 11 published cases of infective endocarditis due to T. beigelii. Read More

Mil Med Res 2021 03 9;8(1):19. Epub 2021 Mar 9.

Department of Dermatology, The Seventh Medical Center of PLA General Hospital, 5 Nanmencang, Dongcheng District, Beijing, 100700, China.

Background: Invasive Trichosporon asahii (T. asahii) infection frequently occurs with a high mortality in immunodeficient hosts, but the pathogenesis of T. asahii infection remains elusive. Read More

Mycoses 2021 Mar 14. Epub 2021 Mar 14.

Department of Dermatology, The Seventh Medical Center, PLA General Hospital, Peking, China.

Background: Trichosporon asahii (T. asahii) is considered the most prominent species associated with invasive trichosporonosis, but little is known about the pathogenesis of T. asahii infection in the host. Read More

J Med Microbiol 2021 Mar 10;70(3). Epub 2021 Mar 10.

Fungal and Parasitic Molecular Biology Laboratory, School of Medicine, University of Sfax, Sfax, Tunisia.

has been recognized as an opportunistic agent having a limited sensitivity to antifungal treatment. Molecular mechanisms of azole resistance have been rarely reported for . Similar to other fungi, we hypothesized that both gene mutation and efflux pumps genes hyper-expression were implicated. Read More

Curr Microbiol 2021 Apr 9;78(4):1636-1642. Epub 2021 Mar 9.

Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.

Candida famata has been associated with the identifiable Candida infections that takes place in human and the identification error of this species possibly will result in misinterpretation of antifungal susceptibility and improper diagnosis; which will have a major effect on the prognosis and therapy of patients. Our objective is to correctly identify Candida spp. collected from patients at the intensive care units, New Cairo University teaching hospital in Cairo-Egypt using matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS). Read More

J Laryngol Otol 2021 Mar 17;135(3):217-223. Epub 2021 Feb 17.

Department of ENT, Christian Medical College, Vellore, India.

Objective: This study aimed to describe the clinical presentation, microbiological profile and management of complications of bone wax usage for surgical procedures at the skull base.

Method: The case records of a series of five patients who developed post-operative surgical site complications because of bone wax usage during skull base surgery were reviewed.

Results: In all five patients, persistent site-specific clinical features were noted along with intra-operative presence of excessive bone wax. Read More

Med Mycol 2021 Feb 7. Epub 2021 Feb 7.

Specialized Medical Mycology Center, Postgraduate Program in Medical Microbiology, Department of Pathology and Legal Medicine, Federal University of Ceará. Rua Cel. Nunes de Melo, 1315 - Rodolfo Teófilo - CEP: 60430-275, Fortaleza, Ceará, Brazil.

Invasive fungal infections (IFIs) are important worldwide health problem, affecting the growing population of immunocompromised patients. Although the majority of IFIs are caused by Candida spp., other fungal species have been increasingly recognized as relevant opportunistic pathogens. Read More

Case Rep Infect Dis 2020 29;2020:8847853. Epub 2020 Dec 29.

Department of Microbiology, AIIMS Rishikesh, Rishikesh, India.

bloodstream infection is the major cause of increased morbidity and mortality (20-49%) in hospitalized patients in both paediatric and adult age groups. Due to the increase in the number of immunocompromised patients, other important species such as and are emerging. One such organism, , previously known as (teleomorph stages of several species), is increasingly being reported as a cause of fungemia in neonatal intensive care units and is now increasingly being reported in a lot of immunosuppressive conditions such as interstitial lung disease, endocarditis, enteritis, corticosteroids, and chemotherapy uptake. Read More

Med Mycol 2021 May;59(5):409-421

Mycology Laboratory, College of Medicine, Federal University of Rio Grande, Rio Grande, RS, Brazil.

Fungal infections are one of the most prevalent diseases in the world and there is a lack of new antifungal drug development for these diseases. We conducted a systematic review of the literature regarding the in vitro antifungal activity of the organoselenium compounds ebselen (Eb) and diphenyl diselenide [(PhSe)2]. A systematic review was carried out based on the search for articles with data concerning Minimal Inhibitory Concentration (MIC) values, indexed in international databases and published until August 2020. Read More

Mycopathologia 2021 Mar 3;186(1):113-117. Epub 2021 Jan 3.

Department of Hematology and Oncology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-shimoaizuki, Eiheiji-cho, Fukui, Yoshida-gun, 910-1193, Japan.

Invasive trichosporonosis is a rare and lethal fungal infection that occurs in immunocompromised patients. Breakthrough trichosporonosis can occur in patients treated with echinocandins since Trichosporon spp. are resistant to these antifungal agents. Read More

J Formos Med Assoc 2020 Dec 23. Epub 2020 Dec 23.

Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Laboratory Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan; Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address:

Background/purpose: Invasive Trichosporon infections are emerging, but association of different therapeutic management of Trichosporon fungemia and clinical outcomes were rarely reported. This study investigates the epidemiology, species distribution and genotypes of trichosporonosis in Taiwan, and identified the predictors of clinical outcomes in patients with Trichosporon fungemia.

Methods: Strains collected from four medical centers in Taiwan, during 2010-2018. Read More

Antimicrob Agents Chemother 2021 02 17;65(3). Epub 2021 Feb 17.

Laboratório Especial de Micologia, Division of Infectious Diseases, Universidade Federal de São Paulo, São Paulo, Brazil

is an opportunistic fungal pathogen that can cause severe infections with high mortality rates. Azole derivatives are the best-targeted therapy for invasive infections, but azole-resistant isolates have been reported. To investigate peculiarities in the antifungal susceptibility profile (ASP) of clinical isolates, we analyzed the genotype distribution, isolation sources, and ASP of 284 strains collected from 1997 to 2019 in different Brazilian medical centers. Read More

Lasers Surg Med 2020 Nov 8. Epub 2020 Nov 8.

Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 West Yanjiang Road, Guangzhou, 510120, China.

Background And Objectives: Trichosporiosis is an opportunistic infection that includes superficial infections, white piedra, hypersensitivity pneumonitis, and invasive trichosporonosis. The effect of antifungal agents against these infections is largely weakened by drug resistance and biofilms-related virulence. Photodynamic therapy (PDT) is a new therapeutic approach developed not only to combat cancerous lesions but also to treat infectious diseases such as fungal infections. Read More

Medicine (Baltimore) 2020 Oct;99(41):e22584

Department of Infectious Diseases, Chonnam National University Hospital.

Nationale: Trichosporon species are widely distributed in nature and are emerging opportunistic human pathogens. Trichosporon infections are associated with superficial cutaneous involvement in immunocompetent individuals to severe systemic disease in immunocompromised patients. Until now, there is no report in infective endocarditis by Trichosporon mucoides confirmed by molecular diagnostics PATIENT CONCERNS:: A 66-year-old man presented with a fever that had occurred for a period of 6 months. Read More

Open Forum Infect Dis 2020 Sep 18;7(9):ofaa365. Epub 2020 Aug 18.

Department of Clinical Laboratory, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.

spp. are emerging opportunistic agents that cause systemic diseases and life-threatening disseminated disease in immunocompromised hosts. is a highly rare cause of invasive trichosporonosis. Read More

J Infect Chemother 2021 Jan 13;27(1):86-89. Epub 2020 Sep 13.

Department of Clinical Laboratory, Ningbo First Hospital, Ningbo, 315010, Zhejiang, China. Electronic address:

Trichosporon loubieri is an opportunistic pathogenic fungus that could causes invasive infections for human, which rarely been reported. In the present study, we reported a case of bloodstream infection from a patient with Ph-positive B-cell acute lymphocytic leukemia (B-ALL) due to Trichosporon loubieri. Trichosporon loubieri was identified by Internal Transcribed Spacer (ITS) gene sequencing. Read More

Mycoses 2021 Jan 23;64(1):42-47. Epub 2020 Sep 23.

Department of Microbiology, Meiji Pharmaceutical University, Tokyo, Japan.

Background: Trichosporon asahii is the major causative agent of disseminated and deep-seated trichosporonosis. It is capable of forming biofilms on surfaces, leading to medical device-related infection.Trichosporon asahii may be present as yeast form, hyphae and/or arthroconidia; however, the relationship between its biofilm-forming ability and its morphological transition is unclear. Read More

Med Mycol 2021 Mar;59(3):296-300

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

We performed retrospective study to identify the characteristics of invasive Trichosporon asahii infection. A total of 102 patients with T. asahii were identified including 18 (18%) with invasive infection. Read More

Poult Sci 2020 Sep 24;99(9):4530-4538. Epub 2020 Jun 24.

The College of Veterinary Medicine, Agricultural University of Hebei, Baoding 071001, China. Electronic address:

In this study, a strain of Trichosporon was isolated from white pseudomembranes and ulcers formed on mucous membranes of pigeon bursas and was identified through gene sequencing. Bacteriostatic actions of Acorus gramineus, Sophora flavescens, Polygonum hydropiper, and Chinese herbal mixture on this species were explored in vitro, and the minimum inhibitory concentration of herbal medicines against Trichosporon was determined through microdilution method. Therapeutic effects of herbal medicines on chickens infected by Trichosporon were studied, whose results showed that minimum inhibitory concentration of A. Read More

Malays J Pathol 2020 Aug;42(2):293-296

Universiti Kebangsaan Malaysia Medical Centre, Faculty of Medicine, Department of Medical Microbiology and Immunology, kuala Lumpur, Malaysia.

Trichosporon asahii is a yeast-like fungus that is emerging as an important cause of invasive infections in tertiary medical centres. A 58-year-old Chinese man with no known medical illnesses presented with liver lacerations and multiple fractures following an alleged 12-foot fall at a construction site. The gravity of his injuries and poor haemodynamic status necessitated an intensive care unit (ICU) admission, during which several febrile episodes were detected and multiple antibiotics were administered. Read More

J Endourol Case Rep 2019 2;5(4):167-170. Epub 2019 Dec 2.

Department of Radio-diagnosis, Pondicherry Institute of Medical Science, Puducherry, India.

Fungal masses (fungal ball or bezoars) rarely present as renal calculus. More so, Trichosporon species are even more uncommon among the noncandidial fungal infections affecting urinary tract. We report two such interesting cases that are not yet reported in the current literature. Read More

Cureus 2020 Jul 2;12(7):e8973. Epub 2020 Jul 2.

Pathology, Aga Khan University, Karachi, PAK.

Of late, fungal infections are increasingly being recognized in diabetic patients. Here we present a case of polymicrobial fungal empyema due to Trichosporon species and Fusarium species developed after community-acquired pneumonia in a diabetic patient. Trichosporon species are basidiomycetous yeast and Fusarium species are soil saprophytes with a worldwide distribution. Read More

Infect Drug Resist 2020 14;13:2329-2354. Epub 2020 Jul 14.

Department of Medical Parasitology and Mycology, Arak University of Medical Sciences, Arak, Iran.

In patients with hematologic malignancies due to immune system disorders, especially persistent febrile neutropenia, invasive fungal infections (IFI) occur with high mortality. Aspergillosis, candidiasis, fusariosis, mucormycosis, cryptococcosis and trichosporonosis are the most important infections reported in patients with hematologic malignancies that undergo hematopoietic stem cell transplantation. These infections are caused by opportunistic fungal pathogens that do not cause severe issues in healthy individuals, but in patients with hematologic malignancies lead to disseminated infection with different clinical manifestations. Read More

Antibiotics (Basel) 2020 Jul 16;9(7). Epub 2020 Jul 16.

Department of Molecular Biology, Area of Microbiology, Faculty of Biology, Universidad de León, 24071 León, Spain.

The rise in the number of immunocompromised patients has led to an increased incidence of fungal infections, with high rates of morbidity and mortality. Furthermore, misuse of antifungals has boosted the number of resistant strains to these agents; thus, there is urgent need for new drugs against these infections. Here, the in vitro antifungal activity of filipin III metabolic intermediates has been characterized against a battery of opportunistic pathogenic fungi-, , , , , , , , and -using the Clinical and Laboratory Standards Institute broth microdilution method. Read More

Mycopathologia 2020 Aug 23;185(4):705-708. Epub 2020 Jul 23.

Department of Internal Medicine, Division of Infectious Diseases, University of California-Davis Health, 4150 V Street, Suite G500, Sacramento, CA, USA.

Opportunistic fungal pathogens have increased in frequency with the growing immunosuppressed population. New and emerging pathogens, including the rare yeasts, continue to cause significant morbidity and mortality and frequently develop despite prophylaxis with antifungal agents. We report a previously unreported manifestation of disseminated trichosporonosis. Read More