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J Pediatr Hematol Oncol 2019 Jan 22. Epub 2019 Jan 22.

Department of Pharmacy Practice, Amrita School of Pharmacy.

Trichosporon asahii is a rare opportunistic fungal pathogen that causes fatal systemic infection in immunocompromised patients. Neutropenia developing due to malignancies is an important risk factor for fungal infection. Invasive infections due to T. Read More

Med Mycol 2019 Jan 15. Epub 2019 Jan 15.

Faculty of Medicine, Post Graduate Program in Medical Microbiology, Federal University of Ceará, Brazil.

Trichosporon species have been considered important agents of opportunistic systemic infections, mainly among immunocompromised patients. Infections by Trichosporon spp. are generally associated with biofilm formation in invasive medical devices. Read More

Braz J Microbiol 2019 Jan 4;50(1):99-105. Epub 2018 Dec 4.

Department of Clinical Microbiology Laboratory, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Soochow, 215006, China.

In this multicenter study, we compared the performance of the Bruker Biotyper MS system and VITEK 2 YST systems for invasive yeast identification, investigated the distribution of isolated species, and evaluated the antifungal susceptibility profiles of Candida albicans, Candida parapsilosis, and Candida tropicalis. In cases of discrepant results lack of identification with either method, molecular identification techniques were employed. We tested 216 clinical isolates, and concordance between the two methods was observed for 192/216 isolates (88. Read More

Med Mycol Case Rep 2019 Mar 26;23:26-28. Epub 2018 Oct 26.

Brooke Army Medical Center, 3551 Roger Brooke Drive, San Antonio, TX, USA.

Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. Read More

J Lab Physicians 2018 Oct-Dec;10(4):464-470

Department of Microbiology, Jagadguru Sri Shivarathreeshwara Medical College, Mysore, Karnataka, India.

Urinary tract infections (UTIs) caused by fungi, frequently associated with medical devices, have increased and caused great morbidity and mortality among hospitalized patients. Difficulties on different species identification as well as the lack of standardized sensitivity tests , contribute to the limited information available on epidemiology, diagnosis, and therapeutics of infections. There are only sporadic reports of UTI caused by reported from India. Read More

J Lab Physicians 2018 Oct-Dec;10(4):380-386

Department of Microbiology, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.

Background: Invasive infections due to spp. have increased recently and are frequently associated with indwelling medical devices. Such infections which are associated with biofilm formation do not respond to the routinely used antifungal agents and are often persistent, associated with high mortality rate. Read More

J Med Microbiol 2019 Jan 27;68(1):81-86. Epub 2018 Nov 27.

National Institute of Health Dr. Ricardo Jorge - Reference Unit for Parasitic and Fungal Infections - Infectious Diseases Department, Lisbon, Portugal.

Purpose: Tissue samples from patients with suspicion of deep or subcutaneous fungal infections were analysed at the Portuguese Reference Mycology Laboratory according to a proposed diagnostic approach, which aims to constitute a rapid and accurate diagnosis for these fungal infections.

Methodology: Forty-six tissue biopsy samples were analysed over a period of 26 months, using a diagnostic approach that includes culture, panfungal PCR and Aspergillus-directed PCR.Results/Key findings. Read More

J Cutan Pathol 2019 Feb 18;46(2):159-161. Epub 2018 Dec 18.

Department of Dermatology, Columbia University Medical Center, New York, New York.

We report a case of disseminated Trichosporon asahii in a patient on systemic antifungal therapy who presented with multiple cutaneous nodules suggestive of fungal infection. Histologic features resembled neutrophilic eccrine hidradenitis but staining with periodic acid-Schiff and Gomori methenamine silver confirmed the clinical diagnosis. This case highlights the importance of maintaining suspicion for trichosporonosis and contextualizing histologic findings within the underlying clinical picture. Read More

J Clin Microbiol 2019 Feb 30;57(2). Epub 2019 Jan 30.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China

A total of 133 clinical isolates were collected in the National China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program in 2009 to 2016. Accurate identification was performed by sequencing of the intergenic spacer 1 (IGS1) region. Among these isolates, (108 isolates [81. Read More

Vector Borne Zoonotic Dis 2018 Nov 1. Epub 2018 Nov 1.

2 Department of Bacteriology, Mycology and Immunology, Faculty of Veterinary Medicine, University of Sadat City , Sadat City, Egypt .

As human populaces develop, they are progressively squeezed into higher living densities. The same is true for horticulture and animals expected to bolster these communities. Despite the high potential for zoonotic transmission, connections among humans and cattle have been understudied; however, Candida albicans remains the most important medical mycosis. Read More

Diagn Microbiol Infect Dis 2019 Feb 21;93(2):112-119. Epub 2018 Sep 21.

Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands; Shanghai Key Laboratory of Molecular Medical Mycology, Shanghai Institute of Medical Mycology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China; Institute of Biodiversity and Ecosystem Dynamics, University of Amsterdam, Amsterdam, the Netherlands. Electronic address:

Identification of opportunistic yeasts in developing countries is mainly performed by phenotypic assays, which are time-consuming and prone to errors. Wrong species identification may result in suboptimal treatment and inaccurate epidemiological data. To improve rapidity and accuracy of species identification, a diagnostic strategy using a stepwise "YEAST PANEL multiplex PCR assays" targeting 21 clinically important yeast species of Candida, Trichosporon, Rhodotorula, Cryptococcus, and Geotrichum was designed. Read More

Infect Drug Resist 2018 9;11:1659-1667. Epub 2018 Oct 9.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China,

Purpose: In this study, we report results from a 5-year surveillance for noncandidal yeast species causing invasive infections from 65 hospitals in China.

Materials And Methods: Species identification was carried out by matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS) supplemented by rDNA sequencing, and fluconazole and voriconazole susceptibilities of yeasts were determined by Clinical and Laboratory Standards Institute (CLSI) disk diffusion methods.

Results: Overall, 884 noncandidal isolates belonging to 38 species were collected. Read More

Curr Med Mycol 2018 Jun;4(2):14-20

Department of Pathology and Laboratory Medicine, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Background And Purpose: Candidemia is one of the most important fungal infections caused by species. Infections and mortality caused by species have been on a growing trend during the past two decades. The resistance of yeasts to antifungal drugs and their epidemiological issues have highlighted the importance of accurately distinguishing the yeasts at the species level. Read More

Mycoses 2018 Oct 11. Epub 2018 Oct 11.

Department of Dermatology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Background: Emergence of highly inflammatory genital dermatophyte infections has been reported from Southeast Asia. In view of this, knowledge of the non-outbreak fungal flora of the genitals is required as a baseline study.

Objectives: We present our 12-year experience in a tertiary clinic with the diagnosis of scrotal fungal infections. Read More

J Dermatol 2018 Oct 8. Epub 2018 Oct 8.

Department of Dermatology, School of Medicine and University Hospital Dr Jose Eleuterio Gonzalez, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico.

Infect Drug Resist 2018 20;11:1537-1547. Epub 2018 Sep 20.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China,

Background: is a rare fungal species that has not been described in human invasive infections.

Patients And Methods: In this study, we investigated two isolates from patients with invasive infections in two hospitals in China, as part of the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program. Both patients were under immunocompromised conditions. Read More

Fungal Genet Biol 2018 Dec 27;121:46-55. Epub 2018 Sep 27.

Instituto de Microbiologia Paulo de Góes (IMPG), Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil; Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, Brazil. Electronic address:

Trichosporon asahii shares with Cryptococcus species the ability to produce glucuronoxylomannan (GXM), an immunomodulatory fungal polysaccharide. The ability of other opportunistic species of Trichosporon to produce GXM-like polysaccharides is unknown. In this study, we observed that T. Read More

J Fish Dis 2018 Nov 26;41(11):1719-1732. Epub 2018 Sep 26.

Botany and Microbiology Department, Faculty of Science, Assiut University, Assiut, Egypt.

One hundred and twenty-nine isolates of Trichosporon jirovecii were isolated from the melanized exoskeleton as well as eyestalks, gills, muscle and haemolymph of red swamp crayfish (Procambarus clarkii) collected from the River Nile, during summer 2015. Isolates were similar morphologically, biochemically and genetically. Also, random amplified polymorphic DNA (RAPD) analysis exhibited no polymorphism among the tested isolates. Read More

BMC Infect Dis 2018 Sep 18;18(1):470. Epub 2018 Sep 18.

Centro de Ciências da Saúde, Laboratório de Micologia Médica e Molecular, Departamento de Análises Clínicas e Toxicológicas, Universidade Federal do Rio Grande do Norte, Rua Gal. Gustavo Cordeiro de Faria S/N, Petrópolis, Natal, Rio Grande do Norte, Brazil.

Background: Trichosporon species may colonize the skin, respiratory tract and gastrointestinal tract of human beings. The yeast is recognized as etiological agent of white piedra, a superficial mycosis. Nevertheless, immunocompromised hosts may develop invasive Trichosporonosis. Read More

Med Mycol 2018 Sep 12. Epub 2018 Sep 12.

Department of Microbial Science and Host Defense, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.

Trichosporon asahii is a human fungal pathogen that causes deep-seated infections in immunocompromised patients. While the pathogenic mechanisms of T. asahii remain unknown, our previous studies indicate that adherent colony morphologies were generated from parent strains, which may contribute to their pathogenicity. Read More

Indian J Dermatol 2018 Sep-Oct;63(5):386-390

Department of Dermatology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.

Context: Acne vulgaris is a disorder showing persistent inflammation in the pilosebaceous follicles. It is one of the most prevalent dermatoses that millions of people suffer from globally.

Aim: The aim of this study was to identify species from patients with acne and to determine their drugs susceptibility. Read More

J Investig Med High Impact Case Rep 2018 Jan-Dec;6:2324709618795268. Epub 2018 Aug 21.

Kern Medical-University of California Los Angeles, Bakersfield, CA, USA.

is a rare cause of fungal infection in immunocompromised patients, mainly seen in hematological malignancies. infections are extremely rare in immunocompetent patients, as it is part of normal human microbial flora. We are presenting an extremely rare case of peritonitis in an otherwise immunocompetent patient who suffered from gastrointestinal leakage due to pancreatitis. Read More

Int J Hyg Environ Health 2018 09 23;221(8):1107-1115. Epub 2018 Aug 23.

National Institute for Public Health and the Environment, Centre for Zoonoses and Environmental Microbiology, P.O. Box 1, 3720 BA Bilthoven, The Netherlands.

Possible transmission pathways of fungi in indoor swimming pool facilities were assessed through fungal counting in different areas of the facilities and typing of the collected fungal isolates. Air, water and surface samples were collected from seven different indoor swimming pool facilities. Fungal species were identified based on their internal transcribed spacer (ITS) sequences. Read More

Br J Dermatol 2018 Aug 16. Epub 2018 Aug 16.

Laboratory of Dermatoimmunology, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Deficiency of CARD9 (caspase recruitment domain-containing protein 9) has been reported in individuals with recurrent and invasive fungal infections. We report on a patient who first had Trichosporon asahii affecting the skin then Candida albicans infections involving the digestive tract and knee joint, along with elevated serum IgE. After stimulation with C. Read More

Folia Microbiol (Praha) 2019 Jan 30;64(1):73-81. Epub 2018 Jul 30.

Department of Biotechnology, University of Chemistry and Technology, Prague, Technická 5, 166 28, Prague, Czech Republic.

Microorganisms that cause chronic infections exist predominantly as surface-attached stable communities known as biofilms. Microbial cells in biofilms are highly resistant to conventional antibiotics and other forms of antimicrobial treatment; therefore, modern medicine tries to develop new drugs that exhibit anti-biofilm activity. We investigated the influence of a plant polyphenolic compound resveratrol (representative of the stilbene family) on the opportunistic pathogen Trichosporon cutaneum. Read More

Infect Chemother 2018 Jun;50(2):138-143

Division of Infectious Diseases, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Because primary antifungal prophylaxis is widely used for immunocompromised hosts, the incidences of unusual fungal infections have increased. Trichosporon asahii has emerged as an important life-threatening opportunistic systemic pathogen because of the increased use of cytotoxic or immunosuppressant agents, along with high mortality rates. Here, we describe a case of catheter-related T. Read More

Mol Plant Microbe Interact 2018 12 3;31(12):1257-1270. Epub 2018 Oct 3.

1 Agricultural Biotechnology Research Center, Academia Sinica, Taipei 11529, Taiwan; and.

Plant viruses cause devastating diseases in plants, yet no effective viricide is available for agricultural application. We screened cultured filtrates derived from various soil microorganisms cultured in vegetable broth that enhanced plant viral resistance. A cultured filtrate, designated F8 culture filtrate, derived from a fungus belonging to the genus Trichosporon, induced strong resistance to various viruses on different plants. Read More

Neurobiol Dis 2018 Sep 1;117:42-61. Epub 2018 Jun 1.

Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM), c/Nicolás Cabrera, 1. Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. Electronic address:

Multiple sclerosis (MS) is the prototypical inflammatory disease of the central nervous system (CNS), leading to multifocal demyelination and neurodegeneration. The etiology of this incurable disease is unknown and remains a matter of intensive research. The possibility that microbial infections, such as viruses or bacteria, can trigger an autoimmune reaction in CNS tissue has been suggested. Read More

Infection 2018 Aug 21;46(4):443-459. Epub 2018 May 21.

Department of Diagnostics and Treatment of Parasitic Diseases and Mycoses, Medical University of Lodz, Pomorska 251, 92-213, Lodz, Poland.

Background: Fungal infections of the central nervous system (FIs-CNS) have become significantly more common over the past 2 decades. Invasion of the CNS largely depends on the immune status of the host and the virulence of the fungal strain. Infections with fungi cause a significant morbidity in immunocompromised hosts, and the involvement of the CNS may lead to fatal consequences. Read More

Fungal Biol 2018 05 2;122(5):283-292. Epub 2018 Feb 2.

Nangui Abrogoua University, Laboratory of Biotechnology and Food Microbiology, Department of Food Science and Technology (UFR-STA), 02 BP 801 Abidjan 02, Cote d'Ivoire.

The increase of infections due to non-Candida albicans species made it very necessary to conduct adequate characterization to be able to identify the species of Candida isolated from traditional fermented foods. In this study, based on their hue on Candida Chromogenic Agar medium, a total of 136 yeast strains were isolated from tchapalo and bangui. Molecular identification based on PCR-RFLP of internal transcribed spacers of rDNA (ITS) and sequencing of the ITS and the D1/D2 regions allowed us to assign these isolates to seven species: Candida tropicalis, Candida inconspicua, Candida rugosa, Saccharomyces cerevisiae, Kluyveromyces marxianus, Hanseniaspora guilliermondii, Trichosporon asahii. Read More

Dig Surg 2019 12;36(1):59-66. Epub 2018 Apr 12.

Department of Gastroenterological Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.

Background: Invasive fungal infection (IFI) is associated with high mortality after living donor liver transplant (LDLT). The aim of this study was to identify the risk factors for post-LDLT IFI for early diagnosis and improvement of antifungal treatment outcome.

Methods: Risk analysis data were available for all 153 patients who underwent LDLT between January 2005 and April 2012. Read More

Arthroplast Today 2018 Mar 28;4(1):24-26. Epub 2017 Jul 28.

Department of Orthopedic Surgery, Austral University Hospital, Adult Reconstruction Section, Buenos Aires, Argentina.

An immunocompromised patient with a history of multiple hip implant revisions extended courses of empiric antibiotic treatment, and a retained metallic rod in the femoral medullary canal was transferred for diagnostic studies and treatment. A high suspicion of fungal infection and utilization of extended and specific fungal cultures were the diagnostic keys for infection with . The treatment consisted in a debridement surgery with the use of a functional spacer with cement supplemented with voriconazole and vancomycin plus a 6-month systemic treatment with voriconazole. Read More

Mycoses 2018 Aug 6;61(8):534-542. Epub 2018 Apr 6.

School of Biotechnology, University of Jammu, Jammu, India.

Dermatophytes are considered as the main pathogens responsible for onychomycosis, but recently successive isolations of yeast-like fungi from the infected nails has led to consider these also as primary agents of nail infections. Trichosporon species which are non-candidal, basidiomycetous, yeast-like, anamorphic fungi are commonly isolated from soil but they are also emerging as important etiological agents of onychomycosis. Three species of Trichosporon viz. Read More

Mycopathologia 2018 Aug 1;183(4):659-668. Epub 2018 Mar 1.

Department of Pharmacy, Universidade Estadual do Centro-Oeste/UNICENTRO, Rua Simeão Camargo Varela de Sá 03, Guarapuava, PR, 85040-080, Brazil.

Amphotericin B (AmB) is one of the most used drugs for the treatment of systemic fungal infections; however, the treatment causes several toxic manifestations, including nephrotoxicity and hemolytic anemia. Chitosan-coated poly(lactide-co-glycolide) (PLGA) nanoparticles containing AmB were developed with the aim to decrease AmB toxicity and propose the oral route for AmB delivery. In this work, the antifungal efficacy of chitosan-coated PLGA nanoparticles containing AmB was evaluated in 20 strains of fungus isolates from patients with vulvovaginal candidiasis (01 Candida glabrata and 03 Candida albicans), bloodstream infections (04 C. Read More

Med Mycol J 2018 ;59(1):E7-E18

Department of Surgical Pathology, Toho University School of Medicine.

The main objective of this study was to evaluate the relationship between histopathology, polymerase chain reaction (PCR), and in situ hybridization (ISH) for the identification of causative fungi in formalin-fixed and paraffin-embedded (FFPE) tissue specimens. Since pathogenic fungi in tissue specimens can be difficult to identify morphologically, PCR and ISH have been usually employed as auxiliary procedures. However, little comparison has been made on the sensitivity and specificity of PCR and ISH using FFPE specimens. Read More

BMJ Case Rep 2018 Jan 6;2018. Epub 2018 Jan 6.

Department of Infectious Diseases, Louisiana State University Health Sciences Center, Shreveport, Louisiana, USA.

A 59-year-old man with a history of peripheral vascular disease status post femoral popliteal bypass presented with critical limb ischaemia of the left leg. An arterial Doppler ultrasound showed an occluded graft requiring an above knee amputation. Five days after surgery, the patient developed fever, leucocytosis, significant stump swelling and pain, and serosanguinous discharge from his wound. Read More

JAAD Case Rep 2018 Jan 18;4(1):27-29. Epub 2017 Dec 18.

Department of Dermatology, Saint-Louis Hospital, Paris, France.

Ann Acad Med Singapore 2017 11;46(11):439-442

Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Rev Iberoam Micol 2018 Jan - Mar;35(1):22-26. Epub 2017 Dec 26.

Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Mexico. Electronic address:

Background: Trichosporon asahii is a yeast-like fungus that has recently gained importance as a cause of opportunistic systemic infections. The pathogenicity and virulence factors of T. asahii remain largely unknown. Read More

Pediatr Dermatol 2018 Jan 20;35(1):e86-e87. Epub 2017 Dec 20.

Department of Dermatology, Baylor College of Medicine, Houston, TX, USA.

Trichosporonosis is a rare, life-threatening, opportunistic fungal infection that affects immunocompromised individuals with neutropenia, particularly those with underlying hematologic malignancies. We present the case of a 10-year-old boy with acute lymphoblastic leukemia who developed a diffuse, morbilliform eruption in the setting of fever and pancytopenia. He was found to have Trichosporon asahii fungemia with widespread visceral dissemination, and his condition rapidly deteriorated despite treatment. Read More

Med Mycol Case Rep 2018 Jun 28;20:1-3. Epub 2017 Nov 28.

Department of Hematology, Tachikawa Hospital, Tokyo 190-8531, Japan.

We encountered a case of a 73-year-old man with acute myeloid leukemia who developed systemic infection while on itraconazole prophylaxis during severe neutropenia. Cryptococcal antigen was useful for diagnosis. Although itraconazole was ineffective in protecting against trichosporonosis, treatment was successful with voriconazole following liposomal amphotericin B. Read More

Sci Rep 2017 Dec 19;7(1):17847. Epub 2017 Dec 19.

Department of Dermatology, PLA Army General Hospital, 5 Nanmencang, Beijing, 100700, China.

Trichosporon asahii (T. asahii) has emerged as a dangerous pathogen that causes rare but life-threatening infections. Its resistance to certain antifungal agents makes it difficult to treat, especially for patients undergoing long-term antibiotic therapy. Read More

Epidemiol Infect 2018 01 4;146(1):58-64. Epub 2017 Dec 4.

Department of Internal Medicine,John H. Stroger, Jr. Hospital of Cook County,Chicago, IL,USA.

Blastoschizomyces capitatus is an uncommon opportunistic yeast associated with infections in neutropaenic patients secondary to haematological malignancies, with a special predilection for the lungs. Globalisation and population migration impact on the epidemiology of infection with this organism but its effect on the immunocompetent population has rarely been described. We present here a case report, an overview of 11 other cases published between 2000 and 2016, and a comprehensive literature review of Blastoschizomyces pneumonia in the non-immunocompromised. Read More

Mycopathologia 2018 Jun 1;183(3):585-590. Epub 2017 Dec 1.

Regional Medical Research Centre (NE Region), Dibrugarh, Assam, India.

Cutaneotrichosporon (Trichosporon) debeurmannianum is a rarely isolated yeast from clinical samples. Nine isolates of this yeast were identified from clinical samples within a period of 3 years from June 2012 to May 2015. These isolates were from blood and urine samples sent to a clinical mycology laboratory of a tertiary care hospital in Assam, North East India. Read More

Mycopathologia 2018 Jun 1;183(3):637-644. Epub 2017 Dec 1.

Department of Preclinical Sciences, Warsaw University of Life Sciences, Warsaw, Poland.

This report describes the isolation of two environmental fungi: Rhodotorula mucilaginosa and Trichosporon jirovecii accompanied by Pseudomonas aeruginosa and Escherichia coli from a dog with bronchotracheitis. All microorganisms were isolated routinely from a mucopurulent discharge, obtained during bronchoscopy from laryngotracheal area. The initial identification of yeasts was confirmed by API Candida and by molecular analysis of internal transcribed spacer region. Read More

F1000Res 2017 31;6:1917. Epub 2017 Oct 31.

Infectious Diseases Research Laboratory, 4th Department of Internal Medicine, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

In the expanding population of immunocompromised patients and those treated in intensive care units, rare fungal infectious agents have emerged as important pathogens, causing invasive infections associated with high morbidity and mortality. These infections may present either as or as breakthrough invasive infections in high-risk patients with hematologic malignancies receiving prophylactic or empirical antifungal therapy or in patients with central venous catheters. Diagnosis and treatment are challenging. Read More

Indian J Pediatr 2019 Jan 11;86(1):83-90. Epub 2017 Nov 11.

Pediatric Neurology and Neurodevelopment Unit, Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.

Central nervous system fungal infections can be broadly divided into those that infect a healthy host such as Cryptococcus, Coccidioides, Histoplasma, Blastomyces, Sporothrix spp., and those that cause opportunistic infections in an immunocompromised host such as Candida, Aspergillus, Zygomycetes, Trichosporon spp. The clinical manifestations of central nervous system fungal infections commonly seen in children in clinical practice include a chronic meningitis or meningoencephalitis syndrome, brain abscess, rhino-cerebral syndrome and rarely, a fungal ventriculitis. Read More

Med Mycol 2018 Jun;56(4):434-441

Departamento de Microbiología and Departamento de Histología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, México.

Trichosporon asahii is an opportunistic yeastlike fungus that colonizes the gastrointestinal and respiratory tracts and human skin. Although it is an important cause of disseminated infections by non-Candida species, there are a few reports related to its virulence factors and their possible role in in vivo pathogenicity. We developed a murine model of disseminated trichosporonosis in immunocompetent mice for the evaluation of the in vivo pathogenicity of 6 T. Read More

Mem Inst Oswaldo Cruz 2017 Oct;112(10):719-722

Universidade Federal de Alfenas, Departamento de Microbiologia e Imunologia, Alfenas, MG, Brasil.

We report the first two cases of Trichosporon mycotoxinivorans infections in Latin America. We also conducted a literature review and a microbiological investigation, including that of clinical and environmental isolates. A 30-year-old man with chronic renal failure had disseminated infection after dialysis and a 15-year-old boy with cystic fibrosis (CF) had pulmonary exacerbations with positive respiratory samples. Read More