227 results match your criteria Trichorrhexis Nodosa


Primary Congenital Trichorrhexis Nodosa with Nevus Achromicus: A Rare Presentation.

Int J Trichology 2018 Jul-Aug;10(4):186-188

Department of Dermatology, Venereology and Leprology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India.

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November 2018

A Case of Progressive Evolution of Multiple Woolly Hair Nevi in a Child.

Int J Trichology 2018 Jul-Aug;10(4):180-182

Department of Dermatology, Venereology and Leprosy, Seth G S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Woolly hair nevus is a rarely acquired disorder of the scalp hair with well-circumscribed patch of curly and unruly hairs which are smaller in diameter than normal surrounding hair. We report a case of progressively evolving multiple woolly hair nevi in a 10-year-old child. Trichoscopy of unruly hairs showed abnormal kinking of hair shafts. Read More

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November 2018
1 Read

Netherton Syndrome: A Case Report and Review of Literature.

Cureus 2018 Jul 30;10(7):e3070. Epub 2018 Jul 30.

Internal Medicine, Icahn School of Medicine at Mount Sinai Queens Hospital Center, New York, USA.

Netherton syndrome (NS) is a rare autosomal recessive disorder characterized by a triad of congenital ichthyosiform erythroderma (CIE) or ichthyosis linearis circumflexa (ILC), hair shaft abnormalities, and atopic diathesis (elevated serum IgE ). We report a case of a two-year-old boy presented with intractable pruritus, scaling, dry skin and generalized eczematous lesions resistant to atopic dermatitis therapy. Netherton syndrome misdiagnosed as atopic dermatitis due to the presence of eczematous skin lesions and allergic problems. Read More

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July 2018
6 Reads

Trichoscopy in Hair Shaft Disorders.

Dermatol Clin 2018 Oct 16;36(4):421-430. Epub 2018 Aug 16.

Department of Dermatology, Medical University of Warsaw, Pawinskiego 5, 02-106, Warszawa, Poland.

Trichoscopy allows analyzing the structure and size of growing hair shafts in their natural environment in children and adults. The method replaces light microscopy, which requires pulling of multiple hairs for investigation. In monilethrix, trichoscopy shows uniform elliptical nodosities with intermittent constrictions. Read More

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October 2018
12 Reads

Painful callosities in a young boy.

Pediatr Dermatol 2018 Jul;35(4):509-510

Clinical Hospital of the Federal University of Parana, Curitiba, Parana, Brazil.

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Low prevalence of argininosuccinate lyase deficiency among inherited urea cycle disorders in Korea.

J Hum Genet 2018 Jul 17;63(8):911-917. Epub 2018 May 17.

Department of Pediatrics, Asan Medical Center Children's Hospital, University of Ulsan College of Medicine, Seoul, Korea.

Argininosuccinic aciduria (ASA), which is considered to be the second most common urea cycle disorder (UCD), is caused by an argininosuccinate lyase deficiency and is biochemically characterized by elevation of argininosuccinic acid and arginine deficiency. In addition to hyperammonemia, other characteristic features of ASA include hepatic fibrosis, hypertension, neurocognitive deficiencies, and trichorrhexis nodosa. Herein, we retrospectively reviewed the clinical findings, biochemical profiles, and genotypic characteristics of five Korean patients with ASA, who showed typical phenotypes and biochemical findings of the disease. Read More

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Novel contiguous gene deletion in peruvian girl with Trichothiodystrophy type 4 and glutaric aciduria type 3.

Eur J Med Genet 2018 Jul 5;61(7):388-392. Epub 2018 Feb 5.

Department of Genetic & Inborn Errors of Metabolism, Instituto Nacional de Salud del Niño, Breña, Lima, Peru. Electronic address:

Trichothiodystrophy type 4 is a rare autosomal recessive and ectodermal disorder, characterized by dry, brittle, sparse and sulfur-deficient hair and other features like intellectual disability, ichthyotic skin and short stature, caused by a homozygous mutation in MPLKIP gene. Glutaric aciduria type 3 is caused by a homozygous mutation in SUGCT gene with no distinctive phenotype. Both genes are localized on chromosome 7 (7p14). Read More

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July 2018
15 Reads

Tricho-hepato-enteric syndrome with novel SKIV2L gene mutations: A case report.

Medicine (Baltimore) 2017 Nov;96(46):e8601

aDepartment of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto bDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo cDepartment of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine dDepartment of Medical Supply, Kyoto University Hospital, Kyoto eDepartment of Pediatrics, Kobe City Medical Center General Hospital, Kobe fDivision of Pediatric Endocrinology and Metabolism, Children's Medical Center, Osaka City General Hospital, Osaka, Japan.

Rationale: Tricho-hepato-enteric syndrome (THES) is a rare disorder caused by mutations in the TTC37 or SKIV2L genes and characterized by chronic diarrhea, liver disease, hair abnormalities, and high mortality in early childhood due to severe infection or liver cirrhosis.

Patient Concerns: The patient is the second child of three siblings born to non-consanguineous healthy Japanese parents. She had intrauterine growth retardation and was delivered at 33 weeks of gestation due to placental abruption. Read More

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November 2017
11 Reads

Considerations in surgical management of a Buschke-Lowenstein tumor in Netherton syndrome: A case report.

Pediatr Dermatol 2017 Nov;34(6):e328-e330

Department of Dermatology, Great Ormond Street Hospital, London, UK.

Netherton syndrome is an autosomal recessive ichthyosis caused by mutations in SPINK5, with the classic triad of linearis circumflexa, trichorrhexis invaginata, and atopy. There are few reports of surgical management in individuals with Netherton syndrome and clinicians may be reluctant to operate for fear of wound-healing complications. This report describes a pediatric case of a Buschke-Lowenstein tumor of the natal cleft in a patient with Netherton syndrome that had failed to respond to medical management. Read More

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November 2017
21 Reads

Desquamating Rash in a Patient with Undiagnosed Netherton Syndrome.

J Pediatr 2018 Jan 6;192:262-262.e1. Epub 2017 Nov 6.

Department of Pediatrics Vanderbilt University School of Medicine Vanderbilt University Nashville, Tennessee.

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January 2018
3 Reads

Trichoscopy of an Isolated Trichorrhexis Nodosa: A Case Report.

Indian Dermatol Online J 2017 Sep-Oct;8(5):386-387

Department of Dermatology, S. Nijalingappa Medical College, Bagalkot, Karnataka, India.

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October 2017
10 Reads

Hair Loss: Common Causes and Treatment.

Am Fam Physician 2017 Sep;96(6):371-378

Washington Health Systems Family Medicine Residency, Washington, PA, USA.

Hair loss is often distressing and can have a significant effect on the patient's quality of life. Patients may present to their family physician first with diffuse or patchy hair loss. Scarring alopecia is best evaluated by a dermatologist. Read More

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September 2017
3 Reads

Hair and scalp disorders in adult and pediatric patients with skin of color.

Cutis 2017 Jul;100(1):31-35

Callender Dermatology and Cosmetic Center, Glenn Dale, Maryland, USA.

As increasing numbers of patients of African descent seek treatment for hair and scalp-related diseases, it is imperative that all dermatologists be adequately trained to address the concerns of this patient population. We present must-know information to effectively approach the concerns of patients with seborrheic dermatitis, acquired trichorrhexis nodosa, acne keloidalis nuchae, pseudofolliculitis barbae, alopecia, and common pediatric hair and scalp disorders. Read More

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July 2017
10 Reads

Phage Therapy in a 16-Year-Old Boy with Netherton Syndrome.

Front Med (Lausanne) 2017 3;4:94. Epub 2017 Jul 3.

G. Eliava Institute of Bacteriophages, Microbiology and Virology, Tbilisi, Georgia.

Netherton syndrome (NS) is a rare autosomal recessive disorder, characterized by a classical triad of clinical features, including congenital ichthyosiform erythroderma, trichorrhexis invaginata, and atopic diathesis coupled with frequent bacterial infections (1). The genetic basis for the disease has been recently identified with mutations in gene SPINK5, which is involved in the regulation of formation of skin barriers. We report on a 16-year-old male with all the typical manifestations of NS, including atopic diathesis and ongoing serious staphylococcal infections and allergy to multiple antibiotics whose family sought help at the Eliava Phage Therapy Center when all other treatment options were failing. Read More

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July 2017
5 Reads

Noonan syndrome with loose anagen hair associated with trichorrhexis nodosa and trichoptilosis.

Clin Case Rep 2017 07 1;5(7):1152-1154. Epub 2017 Jun 1.

Department of Dermatology University of Massachusetts Medical School 281 Lincoln Street Worcester 01605 Massachusetts.

We report a case of Noonan syndrome with loose anagen hair (NS/LAH), a rare variant of Noonan syndrome, with associated trichorrhexis nodosa and trichoptilosis. The mutation may be responsible for these additional hair shaft defects, revealing the importance of microscopic examination of hairs in these patients. Read More

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July 2017
10 Reads

Trichoscopy of scalp dysesthesia.

Postepy Dermatol Alergol 2017 Jun 29;34(3):245-247. Epub 2017 May 29.

Department of Dermatology, Medical University of Warsaw, Warsaw, Poland.

Introduction: Scalp dysesthesia is characterized by localized pruritus, burning sensations or even pain.

Aim: To describe characteristic trichoscopic features of scalp dysesthesia.

Material And Methods: The study was a retrospective analysis (2010-2016) of 9 patients (8 females and 1 male; median age: 52 years; range: 38-66 years). Read More

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June 2017
8 Reads

Trichorrhexis nodosa due to repetitive trivial trauma.

Indian J Dermatol Venereol Leprol 2017 Nov-Dec;83(6):683

Department of Dermatology, Lokmanya Tilak Municipal General Hospital, Sion Hospital, Mumbai, Maharashtra, India.

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November 2018
16 Reads

Updates in the understanding and treatments of skin & hair disorders in women of color.

Int J Womens Dermatol 2017 Mar 16;3(1 Suppl):S21-S37. Epub 2017 Feb 16.

Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia.

Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Read More

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March 2017
9 Reads

Morphological analyses in fragility of pili torti with Björnstad syndrome.

J Dermatol 2017 Apr 24;44(4):455-458. Epub 2016 Nov 24.

Department of Dermatology, Aichi Medical University School of Medicine, Nagakute, Japan.

Pili torti is an extremely rare hair phenotype characterized by short length of hairs with hair shafts being easily broken. However, the mechanism of fragility in pili torti is unclear. In this study, we examined the underlying morphological features responsible for pili torti formation using transmission electron microscopy (TEM). Read More

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April 2017
13 Reads

Breaking the cycle of hair breakage: pearls for the management of acquired trichorrhexis nodosa.

J Dermatolog Treat 2017 Jun 28;28(4):322-326. Epub 2016 Oct 28.

b Department of Dermatology , Johns Hopkins School of Medicine , Baltimore , MD , USA.

Acquired trichorrhexis nodosa (TN) is a common cause of hair loss for patients of all ethnicities. It is especially prevalent in black patients with tightly curled hair types and can present unique diagnostic and therapeutic challenges due to structural differences in these hair types and the combination of various hair care and styling practices that contribute to hair damage. While scalp biopsies can help rule out other etiologies of hair loss, there is a paucity of histologic findings in acquired TN, making this primarily a clinical diagnosis. Read More

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June 2017
3 Reads

Prognosis and Management of Congenital Hair Shaft Disorders without Fragility-Part II.

Pediatr Dermatol 2016 Sep 13;33(5):481-7. Epub 2016 Jun 13.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.

Hair shaft disorders are characterized by congenital or acquired abnormalities of the hair shaft. The objective of this study was to review the literature regarding the prognosis and treatment options for hair shaft disorders. We used keywords in the search engines PubMed and Medline to identify all publications in English related to the prognosis and management of hair shaft disorders. Read More

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September 2016
9 Reads

Prognosis and Management of Congenital Hair Shaft Disorders with Fragility-Part I.

Pediatr Dermatol 2016 Sep 13;33(5):473-80. Epub 2016 Jun 13.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, Florida.

Hair shaft disorders are characterized by congenital or acquired abnormalities of the hair shaft. The objective was to review the literature regarding the prognosis and treatment options of hair shaft disorders. We used keywords in the search engines PubMed and Medline to identify all publications in the English language related to the prognosis and management of hair shaft disorders. Read More

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September 2016
5 Reads

The Arid Melancholy-Netherton Syndrome With Protein Energy Malnutrition.

J Clin Diagn Res 2016 Apr 1;10(4):WD01-2. Epub 2016 Apr 1.

Junior Resident, Department of Skin and V.D., Mahatma Gandhi Institute of Medical Sciences , Sevagram, Wardha, Maharashtra, India .

Netherton Syndrome (NS) is a rare autosomal recessive hereditary ichthyosiform disease with a classical triad comprising of an ichthyosiform dermatosis, hair shaft abnormalities and atopic diathesis. There is a mutation in a gene named Serine Protease Inhibitor Kazal type-5 (SPINK5); a new type of serine protease inhibitor involved in the regulation of skin barrier formation and immunity. Skin manifestations include, Ichthyosis Linearis Circumflexa (ILC), polycyclic and serpiginous, erythematous plaques with characteristic migratory, double-edged scale at the margins, or Congenital Ichthyosiform Erythroderma (CIE). Read More

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April 2016
2 Reads

Identifying Mutations of the Tetratricopeptide Repeat Domain 37 (TTC37) Gene in Infants With Intractable Diarrhea and a Comparison of Asian and Non-Asian Phenotype and Genotype: A Global Case-report Study of a Well-Defined Syndrome With Immunodeficiency.

Medicine (Baltimore) 2016 Mar;95(9):e2918

From the Primary Immunodeficiency Care and Research (PICAR) Institute (W-IL, J-LH) and Division of Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung Memorial Hospital, Chang Gung University College of Medicine (W-IL, J-LH, T-HJ, L-SO); and Division of Gastroenterology (C-CC), Division of Genetics and Endocrinology (J-LL), Division of Hematology/Oncology, Department of Pediatrics (T-HJ), and Department Pathology, Chang Gung Memorial Hospital (R-CW), Taoyuan, Taiwan.

Syndromic diarrhea/tricho-hepato-enteric syndrome (SD/THE) is a rare, autosomal recessive and severe bowel disorder mainly caused by mutations in the tetratricopeptide repeat domain 37 (TTC37) gene which act as heterotetrameric cofactors to enhance aberrant mRNAs decay. The phenotype and immune profiles of SD/THE overlap those of primary immunodeficiency diseases (PIDs). Neonates with intractable diarrhea underwent immunologic assessments including immunoglobulin levels, lymphocyte subsets, lymphocyte proliferation, superoxide production, and IL-10 signaling function. Read More

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March 2016
13 Reads

Dermatologic findings of focal dermal hypoplasia (Goltz syndrome).

Am J Med Genet C Semin Med Genet 2016 Mar 9;172C(1):44-51. Epub 2016 Feb 9.

Goltz syndrome, caused by mutations in PORCN, is an X-linked dominant ectodermal dysplasia which is also known as focal dermal hypoplasia. This name is derived from the predominant pathologic skin findings of the syndrome. Nineteen Goltz-affected participants attended a multidisciplinary scientific and clinical conference convened by the National Foundation for Ectodermal Dysplasia which allowed further characterization of the features of this very rare condition. Read More

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March 2016
10 Reads

Ichthyosis linearis circumflexa in a child. Response to narrowband UVB therapy.

J Dermatol Case Rep 2015 Dec 31;9(4):110-2. Epub 2015 Dec 31.

Department of Pathology, Okmeydani Training and Research Hospital, Istanbul, Turkey.

Background: Ichthyosis linearis circumflexa is a rare form of ichthyosis characterized by polycyclic and annular lesions which are bordered by a double-edged scale. Netherton syndrome is a genodermatosis in which ichthyosis linearis circumflexa is accompanied by characteristic hair shaft abnormalities and atopic diathesis. Different treatment modalities such as emmolients, keratolytics, calcipotriene, topical corticosteroids, topical calcineurin inhibitors, systemic retinoids, phototherapy and photochemotherapy have been used with variable results. Read More

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December 2015
7 Reads

ICHTHYOSIS LINEARIS CIRCUMFLEXA: NOT ALWAYS A PART OF NETHERTON SYNDROME.

Genet Couns 2016;27(3):353-356

Ichthyosis Linearis Circumfiexa (ILC) is a rarely seen autosomal recessive keratinization disorder and is characterized by erythematous, polycystic, plaques with 'double-edged' scales. Its histological features resemble psoriasis. A triad of ichthyosis (usually Ichthyosis Linearis Circumfiexa), trichorrhexis invaginata (a distinctive hair shaft disorder) and atopy is named as Netherton syndrome. Read More

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October 2018
1 Read

Ethnic hair disorders.

Curr Probl Dermatol 2015 20;47:139-49. Epub 2015 Feb 20.

The management of hair and scalp conditions is difficult in any patient, especially given the emotional and psychological implications of hair loss. This undertaking becomes even more challenging in the ethnic patient. Differences in hair care practices, hair shaft morphology, and follicular architecture add complexity to the task. Read More

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June 2016
5 Reads

Hair loss in children.

Curr Probl Dermatol 2015 20;47:55-66. Epub 2015 Feb 20.

Hair diseases represent frequent complaints in dermatology clinics, and they can be caused by a number of conditions reflected by specific diagnoses. Hair loss is not uncommon in the pediatric group, but its patterns in this group are different from those seen in adults. Additionally, in children, these disorders can have psychological effects that can interfere with growth and development. Read More

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June 2016
7 Reads

Trichorrhexis nodosa: a distinctive presentation after tumour necrosis factor-α inhibitor therapy.

Clin Exp Dermatol 2016 Apr 24;41(3):313-4. Epub 2015 Jul 24.

Dermatology Department, Brighton and Sussex University Hospitals NHS Trust, Brighton General Hospital, Elm Grove Brighton, BN2 3EW, UK.

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April 2016
5 Reads

Updates in the understanding and treatments of skin & hair disorders in women of color.

Int J Womens Dermatol 2015 Jun 27;1(2):59-75. Epub 2015 May 27.

Department of Dermatology, Howard University College of Medicine, Washington, District of Columbia.

Skin of color comprises a diverse and expanding population of individuals. In particular, women of color represent an increasing subset of patients who frequently seek dermatologic care. Acne, melasma, and alopecia are among the most common skin disorders seen in this patient population. Read More

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June 2015
5 Reads

Trichoscopic Hair Evaluation in Patients with Ectodermal Dysplasia.

J Pediatr 2015 Jul 30;167(1):193-5. Epub 2015 Apr 30.

Department of Orthodontics, Medical University of Warsaw, Warsaw, Poland.

Hair abnormalities in ectodermal dysplasia may be difficult to identify. Among 16 patients with ectodermal dysplasia trichoscopy (hair dermoscopy) revealed predominance of pilosebaceous units with 1 hair (69%), abnormalities of hair shaft pigmentation (gray hair with single dark hairs, 56%), pili torti, trichothiodystrophy, trichorrhexis nodosa, and rarely, cicatricial alopecia. Read More

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July 2015
2 Reads

Corrigendum: Novel TTC37 Mutations in a Patient with Immunodeficiency without Diarrhea: Extending the Phenotype of Trichohepatoenteric Syndrome.

Front Pediatr 2015 16;3:28. Epub 2015 Apr 16.

Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital , Houston, TX , USA.

[This corrects the article on p. 2 in vol. 3, PMID: 25688341. Read More

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May 2015
9 Reads

Inability to grow long hair: a presentation of trichorrhexis nodosa.

Cutis 2015 Mar;95(3):E15-6

Department of Dermatology, Catholic University of the Sacred Heart, Largo Gemelli 8, 00168 Rome, Italy.

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March 2015
3 Reads

Penile cancer in a man with netherton syndrome.

Urology 2015 Apr;85(4):e21-2

Department of Urology, University of Minnesota, Minneapolis, MN. Electronic address:

Netherton syndrome (NS) is a rare autosomal recessive skin disease with severe skin inflammation and scaling, a specific hair shaft defect (trichorrhexis invaginata or bamboo hair), and severe atopic manifestations including atopic dermatitis and hay fever with high serum immunoglobulin E levels and hypereosinophilia. NS is caused by loss-of-function mutations in serine protease inhibitor of Kazal-type 5 (SPINK5) encoding lympho-epithelial Kazal-type-related inhibitor (LEKTI) expressed in the stratified epithelia. We report the first case of penile squamous cell carcinoma in a patient with NS. Read More

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April 2015
3 Reads

Pili Annulati and Trichorrhexis Nodosa in the Same Patient: Cause or Coincidence?

Skin Appendage Disord 2015 Mar 11;1(1):25-7. Epub 2015 Feb 11.

Department of Dermatology, University of São Paulo, São Paulo, Brazil.

Purpose: To determine the relationship between pili annulati (PA) and acquired trichorrhexis nodosa (TN) seen in the same patient, considering the two main theories evoked by previous studies: greater stiffness of darker PA bands or associated cuticular damage.

Procedures: Light microscopy of hair shafts from different regions of the patient's scalp.

Results: TN was not superimposed to dark bands of PA. Read More

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March 2015
8 Reads

Ichthyosis Linearis Circumflexa as the Only Clinical Manifestation of Netherton Syndrome.

Acta Derm Venereol 2015 Jul;95(6):720-4

Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell'Immacolata (IDI)-IRCCS, 00167 Rome, Italy.

Ichthyosis linearis circumflexa (ILC) presents as serpiginous and migratory erythematous patches with double-edged scales. ILC is rarely an isolated skin manifestation, but most commonly a part of Netherton syndrome (NS). NS is caused by SPINK5 mutations, which lead to absent or sometimes reduced expression of the serine protease inhibitor LEKTI. Read More

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July 2015
3 Reads

Novel TTC37 Mutations in a Patient with Immunodeficiency without Diarrhea: Extending the Phenotype of Trichohepatoenteric Syndrome.

Front Pediatr 2015 30;3. Epub 2015 Jan 30.

Department of Immunology, Allergy and Rheumatology, Baylor College of Medicine, Texas Children's Hospital , Houston, TX , USA.

Unbiased genetic diagnosis has increasingly associated seemingly unrelated somatic and immunological phenotypes. We report a male infant who presented within the first year of life with physical growth impairment, feeding difficulties, hyperemesis without diarrhea, and abnormal hair findings suggestive of trichorrhexis nodosa. With advancing age, moderate global developmental delay, susceptibility to frequent viral illnesses, otitis media, and purulent conjunctivitis were identified. Read More

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February 2015
6 Reads

Trichoscopy as a diagnostic tool in trichorrhexis invaginata and Netherton syndrome.

An Bras Dermatol 2015 Jan-Feb;90(1):114-6

Centro Universitário do Estado do Pará, Belém, PA, Brazil.

Netherton syndrome is a rare autosomal recessive disease characterized by erythroderma, ichthyosis linearis circumflexa, atopy, failure to thrive and a specific hair shaft abnormality called trichorrhexis invaginata or bamboo hair, considered pathognomonic. We report the case of a 4-year-old boy with erythroderma since birth, growth deficit and chronic diarrhea. Trichoscopy was used to visualize typical bamboo and "golf tee" hair and of key importance to diagnose Netherton syndrome. Read More

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July 2015
3 Reads

Netherton syndrome with ichthyosis linearis circumflexa and trichorrhexis invaginatum.

Dermatol Online J 2014 Dec 16;20(12). Epub 2014 Dec 16.

New York University School of Medicine.

Netherton syndrome is a rare, autosomal recessive disorder that is characterized by congenital ichthyosis, trichorrhexis invaginata, and atopic diathesis. Ichthyosis presents at birth with erythroderma and subsequently evolves into ichthyosis linearis circumflexa; hair shaft abnormalities tend to present later. The disorder is caused by loss-of-function mutations in the SPINK5 (serine protease inhibitor Kazal-type 5) gene that encodes LEKTI (lympho-epithelial Kazal-type related inhibitor), which is a protease inhibitor that counteracts epidermal proteases involved in desquamation. Read More

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December 2014
2 Reads

Hereditary hypotrichosis simplex of the scalp.

Indian J Dermatol 2014 Nov;59(6):634

Department of Dermatology, Skin Research Center, Shahid Beheshti University of Medical Sciences, Shohada-e Tajrish Hospital, Tehran, Iran.

Hereditary hypotrichosis simplex of the scalp is a genetic disorder, characterized by sparse or absent scalp hair without structural defects, in the absence of other ectodermal or systemic abnormalities. Structural hair defects may be presented with a genetic disorder affecting hair growth or part of a congenital syndrome or may indicate underlying metabolic disorders, or may be associated with other diseases. We describe a 26-years-old Persian girl suffering from hypotrichosis simplex of the scalp with trichorrhexis nodosa who had no ectodermal defects and systemic disease. Read More

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November 2014
4 Reads

Recurrent pustular eruption masquerading as pustular psoriasis in Netherton syndrome.

Pediatr Dermatol 2015 Jan-Feb;32(1):147-8. Epub 2014 Dec 2.

Department of Dermatology and Sexually Transmitted Diseases, Lady Hardinge Medical College and Suchita Kriplani Hospital, Shaheed Bhagat Singh Marg, Delhi, India.

We report a unique presentation of Netherton syndrome with recurrent pustular eruptions leading to an erroneous diagnosis of infantile pustular psoriasis. Light microscopy of eyebrow hair showed trichorrhexis invaginata, consistent with Netherton syndrome. Read More

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October 2015
3 Reads

Recurrent hair loss resulting from generalized proximal trichorrhexis nodosa in a nigerian female.

Int J Trichology 2014 Apr;6(2):83-4

Department of Medicine, University of Ibadan, Ibadan, Oyo, Nigeria.

Hair and scalp disorders commonly seen in the African female have been associated with hair care practices. Distal trichorrhexis nodosa (TN) has been commonly reported with various forms of trauma to the hair from hair grooming practices. We report the case of recurrent generalized hair loss resulting from proximal TN in a 28-year-old Nigerian female with atopy. Read More

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April 2014
3 Reads

Rapid and easy diagnosis of Netherton syndrome with dermoscopy.

J Cutan Med Surg 2014 Jul-Aug;18(4):280-2

Background: Netherton syndrome is a rare autosomal recessive disease demonstrating ichthyosis linearis circumflexa, atopic findings, and hair shaft anomalies. Trichorrhexis invaginata is the pathognomonic hair shaft anomaly seen in this syndrome.

Objective: In recent years, hair shaft anomalies have been described as "matchstick" and "golf tee" signs. Read More

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September 2014
9 Reads

Trichorrhexis nodosa after hair transplantation: dermoscopic, pathologic and electron microscopy analyses.

Dermatol Surg 2013 Nov 1;39(11):1721-4. Epub 2013 Nov 1.

Hwang's Hair-Hair Clinic, Seoul, Korea.

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November 2013
3 Reads

Alopecia in genetic diseases.

Authors:
S Calvieri A Rossi

G Ital Dermatol Venereol 2014 Feb;149(1):1-13

Department of Internal Medicine and Medical Specialties, Unit of Dermatology Sapienza University, Rome, Italy -

Congenital abnormalities of the hair shaft are conditions in most cases linked to chemical, biochemical, and morphological alterations, genetically determined. These alterations may be associated with a larger array of symptoms, as mentioned above, or may occur isolated. The number of genes involved and their penetration are responsible for the mode of transmission, severity, and phenotypic expression of the disease. Read More

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February 2014
5 Reads

Microscopic hair changes associated with hair coloring, hair waving and hair ironing in Iranian women.

Pak J Biol Sci 2013 Oct;16(20):1184-8

Department of Dermatology, Tabriz University of Medical Sciences, Sina Hospital, Tabriz, Iran.

Although, of no vital value, hair plays a significant role in expressing any person's psychosocial status. Many cosmetic and styling methods are available for hair. This study aimed to examine the microscopic changes in women with hair coloring, hair waving, or hair ironing in comparison with normal controls. Read More

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October 2013
1 Read

Noninflammatory, nonpruritic alopecia of horses.

Authors:
Rod A W Rosychuk

Vet Clin North Am Equine Pract 2013 Dec 10;29(3):629-41. Epub 2013 Oct 10.

Department of Clinical Sciences, Colorado State University, 300 West Drake, Fort Collins, CO 80523, USA. Electronic address:

Noninflammatory, nonpruritic alopecias are uncommonly encountered in the horse. Alopecia areata, an apparently autoimmune hair follicle bulbitis produces focal, multifocal to widespread hair loss. The skin is otherwise normal. Read More

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December 2013
7 Reads

Light microscopic hair abnormalities in children: retrospective review of 119 cases in a 10-year period.

Pediatr Dev Pathol 2014 Jan-Feb;17(1):36-43. Epub 2013 Nov 19.

1  Department of Pathology, Children's Mercy Hospitals and Clinics, Kansas City, MO, USA.

Abnormalities in the hair can be congenital or acquired conditions. Examples of genetic disorders with associated hair abnormalities include Menkes syndrome, Netherton syndrome, uncombable hair syndrome, trichothiodystrophy, and loose anagen hair syndrome. Acquired hair abnormalities can be associated with grooming or use of various hair products. Read More

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May 2014
4 Reads

Hair shafts in trichoscopy: clues for diagnosis of hair and scalp diseases.

Dermatol Clin 2013 Oct;31(4):695-708, x

Department of Dermatology, CSK MSW, Woloska 137, Warsaw 02-507, Poland; Department of Neuropeptides, Mossakowski Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, Warsaw 02-106, Poland; Department of Dermatology, Medical University of Warsaw, Koszykowa 82A, Warsaw 02-008, Poland.

Trichoscopy (hair and scalp dermoscopy) analyzes the structure and size of growing hair shafts, providing diagnostic clues for inherited and acquired causes of hair loss. Types of hair shaft abnormalities observed include exclamation mark hairs (alopecia areata, trichotillomania, chemotherapy-induced alopecia), Pohl-Pinkus constrictions (alopecia areata, chemotherapy-induced alopecia, blood loss, malnutrition), comma hairs (tinea capitis), corkscrew hairs (tinea capitis), coiled hairs (trichotillomania), flame hairs (trichotillomania), and tulip hairs (in trichotillomania, alopecia areata). Trichoscopy allows differential diagnosis of most genetic hair shaft disorders. Read More

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October 2013
18 Reads