8,513 results match your criteria Trichomoniasis


Gold(I) Phosphine Derivatives with Improved Selectivity as Topically Active Drug Leads to Overcome 5-Nitroheterocyclic Drug Resistance in .

J Med Chem 2021 May 11. Epub 2021 May 11.

Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States.

causes the most common, nonviral sexually transmitted infection. Only metronidazole (Mz) and tinidazole are approved for treating trichomoniasis, yet resistance is a clinical problem. The gold(I) complex, auranofin, is active against and other protozoa but has significant human toxicity. Read More

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Deazapurine Nucleoside Analogues for the Treatment of .

ACS Infect Dis 2021 May 11. Epub 2021 May 11.

Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, U.K.

Trichomoniasis is the most common nonviral sexually transmitted disease in humans, but treatment options are limited. Here, we report a resorufin-based drug sensitivity assay for high-throughput microplate-based screening under hypoxic conditions. A 5203-compound enamine kinase library and several specialized compound series were tested for the inhibition of growth at 10 μM with ' values of >0. Read More

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UROGENITAL MIXED INFECTIONS IN REPRODUCTIVE AGED WOMEN WITH PELVIC INFLAMMATORY DISEASE.

Georgian Med News 2021 Mar(312):114-118

1Asfendiyarov Kazakh National Medical University, Department of Obstetrics and Gynecology, Almaty, Kazakhstan.

The purpose of our study was to determine the prevalence of urogenital mixed infections and the sensitivity of mycoplasmas and ureaplasmas to antibiotics in reproductive aged women with pelvic inflammatory disease. 4720 samples of biomaterial were obtained by urethral and cervical canal scrapings in 2360 women of reproductive age with pelvic inflammatory disease (2 samples from each woman). In 2360 samples, Chlamydia trachomatis, Trichomonas vaginalis and Gardnerella vaginalis were determined by multiplex PCR. Read More

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Sexually transmitted infections and factors associated with risky sexual practices among female sex workers: A cross sectional study in a large Andean city.

PLoS One 2021 6;16(5):e0250117. Epub 2021 May 6.

School of Medicine, Universidad Internacional de Ecuador, Quito, Ecuador.

Background: There are limited published data on factors related to risky sexual practices (RSP) affecting sexually transmitted infections (STIs) among female sex workers (FSWs) in Ecuador.

Methods: Cross-sectional study of FSWs presenting for a consultation in a primary health care centre during 2017. A questionnaire was administered to collect information on RSP and potential risk factors including age, membership of an FSW association, self-report of previous STI diagnosis, previous treatment for suspected STI and temporary migration for sex work. Read More

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assessment of anti- effects of  and alcoholic extracts on .

Vet Res Forum 2021 15;12(1):95-100. Epub 2021 Mar 15.

Department of Pathobiology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.

is a parasite that acts as a canker-causing agent and leads to significant loss and mortality, especially in young birds. Metronidazole is the approved drug used for the treatment of trichomoniasis. A non-chemical alternativess such as medical plant extracts are also used to treat this disease due to drug resistance. Read More

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Performance of TaqMan probes for the detection of sexually transmitted infections in South African women.

Afr J Lab Med 2021 31;10(1):1124. Epub 2021 Mar 31.

Department of Medical Microbiology, School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

and are the four main aetiologies of sexually transmitted infections responsible for vaginal discharge syndrome (VDS). Commercially available multiplex polymerase chain reaction (PCR) assays are expensive and generally not customisable. We evaluated a highly customisable singleplex PCR approach by testing it in parallel with the Anyplex™ II STI-7 detection assay in a cohort of South African women that presented with VDS between May 2016 and January 2017. Read More

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Development and evaluation of a Point-of-Care Test (POCT) in a low resource setting with high rates of urogenital infections in Fiji.

J Clin Microbiol 2021 Apr 28. Epub 2021 Apr 28.

Lucira Health, Emeryville, CA, USA

Rapid and precise detection of -the leading global cause of sexually transmitted infections (STI)-at the point-of-care (POC) is required for treatment decisions to prevent transmission and sequelae including pelvic inflammatory disease, ectopic pregnancy, tubal-factor infertility and preterm birth. We developed a rapid POC test (POCT), termed LH-POCT, which uses Loop-mediated AMPlification (LAMP) of nucleic acids, and performed a head-to-head comparison with the Cepheid Xpert® CT/NG assay using clinician-collected de-identified paired vaginal samples from a parent study that consecutively enrolled symptomatic and asymptomatic females over age 18 years from the Ministry of Health and Medical Services Health Centers in Fiji. Samples were processed by the Xpert® CT/NG assay and LH-POCT, blinded to the comparator. Read More

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Cloning and characterization of glycogen branching and debranching enzymes from the parasitic protist Trichomonas vaginalis.

Biochimie 2021 Apr 22;186:59-72. Epub 2021 Apr 22.

Departments of Biochemistry & Nutrition, and Microbiology & Immunology, Des Moines University, Des Moines, IA, 50312, USA. Electronic address:

The protist Trichomonas vaginalis is an obligate parasite of humans and the causative agent of trichomoniasis, a common sexually transmitted infection. The organism has long been known to accumulate glycogen, a branched polymer of glucose, and to mobilize this reserve in response to carbohydrate limitation. However, the enzymes required for the synthesis and degradation of glycogen by T. Read More

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Trichomonas vaginalis as a risk factor for human papillomavirus: a study with women undergoing cervical cancer screening in a northeast region of Brazil.

BMC Womens Health 2021 Apr 23;21(1):174. Epub 2021 Apr 23.

Postgraduate Program in Adult Health, Federal University of Maranhão, São Luís, MA, Brazil.

Background: Human papillomavirus (HPV) and Trichomonas vaginalis (TV) infections are the most common sexually transmitted infections (STIs) globally. The latter has contributed to a variety of adverse outcomes for both sexes. Moreover, in Brazil, epidemiological studies on patients with STIs are limited. Read More

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Prevalence assessment of sexually transmitted infections among pregnant women visiting an antenatal care center of Nepal: Pilot of the World Health Organization's standard protocol for conducting STI prevalence surveys among pregnant women.

PLoS One 2021 23;16(4):e0250361. Epub 2021 Apr 23.

Department of Global Programmes of HIV, Hepatitis, STI, World Health Organization, Geneva, Switzerland.

Introduction: Sexually transmitted infections (STIs) are common during pregnancy and can result in adverse delivery and birth outcomes. The purpose of this study was to estimate the prevalence of STIs; Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (syphilis), Trichomonas vaginalis (trichomoniasis), and Human Immunodeficiency Virus (HIV) among pregnant women visiting an antenatal care center in Nepal.

Materials And Methods: We adapted and piloted the WHO standard protocol for conducting a prevalence survey of STIs among pregnant women visiting antenatal care center of Dhulikhel Hospital, Nepal. Read More

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Are Urogenital Symptoms Caused by Sexually Transmitted Infections and Colonizing Bacteria?

J Low Genit Tract Dis 2021 Apr 22. Epub 2021 Apr 22.

Department of Public Health and Clinical Medicine, Dermatology and Venereology, Umeå University, Umeå, Sweden Department of Clinical Microbiology, Umeå University, Umeå, Sweden.

Objective: This study aimed to investigate the prevalence of sexually transmitted infections (STIs) and colonizing bacteria in relation to urogenital symptoms.

Materials And Methods: In this cross-sectional study, patients visiting the STI clinic at Umeå University Hospital were asked for symptoms and condom use. Samples from 759 patients (465 male and 294 female) were analyzed for 4 STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, and Mycoplasma genitalium) and 3 colonizing bacteria (Mycoplasma hominis, Ureaplasma parvum, and Ureaplasma urealyticum). Read More

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Etiologies of genital inflammation and ulceration in symptomatic Rwandan men and women responding to radio promotions of free screening and treatment services.

PLoS One 2021 20;16(4):e0250044. Epub 2021 Apr 20.

Project San Francisco, Rwanda Zambia HIV Research Group, Kigali, Rwanda.

Introduction: The longstanding inadequacies of syndromic management for genital ulceration and inflammation are well-described. The Rwanda National Guidelines for sexually transmitted infection (STI) syndromic management are not yet informed by the local prevalence and correlates of STI etiologies, a component World Health Organization guidelines stress as critical to optimize locally relevant algorithms.

Methods: Radio announcements and pharmacists recruited symptomatic patients to seek free STI services in Kigali. Read More

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Latent Upregulation of and Differentiates between Asymptomatic and Symptomatic Infection.

Immunol Invest 2021 Apr 19:1-22. Epub 2021 Apr 19.

Dr. B. R. Ambedkar Centre for Biomedical Research (ACBR), University of Delhi, Delhi, India.

is a parasitic protozoan that causes trichomoniasis. The involvement of NLRP3 inflammasome in trichomoniasis has been discussed in recent studies. The present study aimed to find out the involvement of , and in the BALB/c mouse model infected with symptomatic and asymptomatic isolates of by quantitative real-time PCR and immunohistochemistry. Read More

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Trichomonas vaginalis infection impairs anion secretion in vaginal epithelium.

PLoS Negl Trop Dis 2021 Apr 16;15(4):e0009319. Epub 2021 Apr 16.

School of Life Sciences, Sun Yat-sen University, Guangzhou, China.

Trichomonas vaginalis is a common protozoan parasite, which causes trichomoniasis associated with severe adverse reproductive outcomes. However, the underlying pathogenesis has not been fully understood. As the first line of defense against invading pathogens, the vaginal epithelial cells are highly responsive to environmental stimuli and contribute to the formation of the optimal luminal fluid microenvironment. Read More

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Photo-genosensor for Trichomonas vaginalis based on gold nanoparticles-genomic DNA.

Photodiagnosis Photodyn Ther 2021 Apr 8;34:102290. Epub 2021 Apr 8.

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Medical Physics, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address:

Trichomoniasis, an infectious disease caused by a parasite called Trichomonas vaginalis (T. vaginalis), enhances the risk of HIV infection, cervical and prostate cancer, and infertility. Therefore, efforts have to be made for accurate, specific, and rapid diagnosise and treatment of trichomoniasis. Read More

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Effectiveness of a Culturally Tailored HIV and Sexually Transmitted Infection Prevention Intervention for Black Women in Community Supervision Programs: A Randomized Clinical Trial.

JAMA Netw Open 2021 Apr 1;4(4):e215226. Epub 2021 Apr 1.

Social Intervention Group, Columbia University School of Social Work, New York, New York.

Importance: Concentrated epidemics of HIV and sexually transmitted infections (STIs) have persisted among Black women in community supervision programs (CSPs) in the United States. Accumulating research has highlighted the effectiveness of culturally tailored HIV/STI interventions for Black women; however, there is a dearth of such interventions for the large number of Black women in CSPs.

Objective: To determine the effectiveness of a 5-session culturally tailored group-based intervention (Empowering African-American Women on the Road to Health [E-WORTH]) with individualized computerized modules and streamlined HIV testing in reducing STIs and condomless sex vs a 1-session streamlined HIV testing control condition. Read More

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Expedited Partner Therapy in Adolescent Females: A Study of Acceptance and the Impact on Reinfection Rates.

Sex Transm Dis 2021 Apr 1. Epub 2021 Apr 1.

University Health Services, University of Wisconsin-Madison Nationwide Children's Hospital The Ohio State University College of Medicine Columbus Health Department Center for Biostatistics at The Ohio State University Biostatistics Resource at Nationwide Children's Hospital The Research Institute at Nationwide Children's Hospital.

Background: Given the high risk of sexually transmitted infections (STI) in adolescents and young adults (AYA), this study evaluated expedited partner therapy (EPT) acceptance and STI reinfection rates in AYA females before and after availability of EPT.

Methods: The pre-EPT cohort was a 3-year (11/2012-11/2015) retrospective chart review of AYA females positive for Chlamydia trachomatis (CT) and/or Trichomonas vaginalis (TV) prior to introduction of EPT. An EPT protocol for CT and TV infections was implemented following legalization in Ohio in 2016. Read More

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Incidence and laboratory diagnosis of sexually-transmitted infections among university students in a high-prevalence community.

J Am Coll Health 2021 Apr 8:1-7. Epub 2021 Apr 8.

College of Health Sciences, Marquette University, Milwaukee, Wisconsin, USA.

Objective: The purpose of this study was to determine the incidence of four sexually-transmitted infection (STI) agents among university students. : A total of 1744 Milwaukee, Wisconsin metropolitan area student encounters at two university health clinics. Following consent, participants completed an eight-item demographic and behavioral questionnaire and provided a specimen for and RNA testing. Read More

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Establishment of suitable reference genes for studying relative gene expression during the transition from trophozoites to cyst-like stages and first evidences of stress-induced expression of meiotic genes in .

Parasitology 2021 Apr 8:1-13. Epub 2021 Apr 8.

Laboratório Integrado de Bioquímica Hatisaburo Masuda (LIBHM), Instituto de Biodiversidade e Sustentabilidade (NUPEM/UFRJ), Universidade Federal do Rio de Janeiro, Macaé/RJ, Brazil.

Trichomonas vaginalis is a parasite of the human urogenital tract and the causative agent of trichomoniasis, a sexually transmitted disease of worldwide importance. This parasite is usually found as a motile flagellated trophozoite. However, when subjected to stressful microenvironmental conditions, T. Read More

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A comparison of the prevalence of sexually transmitted infections among circumcised and uncircumcised adult males in Rustenburg, South Africa: a cross-sectional study.

BMC Public Health 2021 Apr 6;21(1):656. Epub 2021 Apr 6.

Department of Global Health, Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, University of Stellenbosch, Cape Town, South Africa.

Background: South Africa has a persistent burden of sexually transmitted infections (STIs). Male circumcision has been shown to be effective in preventing HIV and STIs, but data are scarce on the protective effect of circumcision in high-risk populations such as migrant miners. The objective of this study was to assess the effect of medical and traditional circumcision on the prevalence of STIs after adjusting for other risk factors in Rustenburg, a mining town in North West Province, South Africa. Read More

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Papanicolaou smear: A diagnostic aid in sexually transmitted infections.

Indian J Sex Transm Dis AIDS 2020 Jul-Dec;41(2):143-148. Epub 2020 Jul 31.

Department of Dermatology and Venereology, Government Medical College, Thiruvananthapuram, Kerala, India.

Background: Sexually transmitted infections (STIs) are a major public health problem in developing countries, and treatment with the right medicine at the right time is necessary to reduce transmission and improve sexual and reproductive health. Laboratory diagnosis has undergone changes in the recent years. The new generation tests are not cost-effective in resource-poor settings. Read More

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Introduction of a complementary screening system for the detection of sexually transmitted infections in patients with sterile pyuria.

Rev Esp Quimioter 2021 Apr 5. Epub 2021 Apr 5.

Helena Gil-Campesino, Department of Microbiology and Infection Control, University Hospital of the Canary Islands. Ctra. del Rosario, 115, 38010 Santa Cruz de Tenerife, Spain.

Objective: The aim of the study was to evaluate a complementary screening system for the detection of sexually transmitted infections in patients with sterile pyuria.

Methods: A prospective study was conducted using Real-time multiplex qPCR in 300 consecutive urine samples with data on sterile pyuria. STI prevalence and patient epidemiological data were analyzed. Read More

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Physicochemical and Microbiological Stability of Compounded Metronidazole Suspensions in PCCA SuspendIt.

Int J Pharm Compd 2021 Mar-Apr;25(2):169-175

College of Pharmacy, Xavier University of Louisiana, New Orleans, Louisiana, United States.

Metronidazole is indicated for the treatment of trichomoniasis, amebiasis, and anaerobic bacterial infections. The dosage regimen of metronidazole needs to be individualized in the treatment of trichomoniasis, in patients with hepatic impairment, and in pediatric as well as geriatric patients. A review of the therapeutic uses of metronidazole reveals the need for flexibility in dosing. Read More

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Atomic Structure of the Trichomonas vaginalis Double-Stranded RNA Virus 2.

mBio 2021 03 30;12(2). Epub 2021 Mar 30.

Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, California, USA

, the causative pathogen for the most common nonviral sexually transmitted infection worldwide, is itself frequently infected with one or more of the four types of small double-stranded RNA (dsRNA) viruses (TVV1 to 4, genus , family ). Each TVV encloses a nonsegmented genome within a single-layered capsid and replicates entirely intracellularly, like many dsRNA viruses, and unlike those in the family. Here, we have determined the structure of TVV2 by cryo-electron microscopy (cryoEM) at 3. Read More

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Risk of HIV acquisition among men who have sex with men infected with bacterial sexually transmitted infections: A systematic review and meta-analysis.

Sex Transm Dis 2021 Mar 16. Epub 2021 Mar 16.

Philip R. Lee Institute for Health Policy Studies, University of California, San Francisco, San Francisco, California, USA Institute for Global Health Sciences, University of California, San Francisco, San Francisco, California, USA Consortium to Assess Prevention Economics, University of California, San Francisco, San Francisco, California, USA Centers for Disease Control and Prevention, Division of HIV/AIDS Prevention, Atlanta, Georgia, USA Centers for Disease Control and Prevention, Division of STD Prevention, Atlanta, Georgia, USA.

Background: Men who have sex with men (MSM) who have bacterial sexually transmitted infections (STIs) are at increased risk for HIV infection. We enhanced and updated past summary risk estimates.

Methods: We systematically reviewed (PROSPERO #CRD42018084299) peer-reviewed studies assessing risk of HIV infection among MSM attributable to: Chlamydia trachomatis (CT), Mycoplasma genitalium (MG), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and/or Trichomonas vaginalis (TV). Read More

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Mother-to-child transmission of Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis in HIV-infected pregnant women in South Africa.

Int J STD AIDS 2021 Mar 26:956462421990218. Epub 2021 Mar 26.

Foundation for Professional Development, Research Unit, East London, South Africa.

Background: Sexually transmitted infections (STIs) can be transmitted from mother to neonate. We determined the frequency of mother-to-child transmission (MTCT) of , , and to the newborn nasopharynx.

Methods: This study was nested in a cohort study of etiologic testing versus syndromic management for STIs among pregnant women living with human immunodeficiency virus in South Africa. Read More

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Efficacy and Safety of Single Oral Dosing of Secnidazole for Trichomoniasis in Women: Results of a Phase 3, Randomized, Double-Blind, Placebo-Controlled, Delayed-Treatment Study.

Clin Infect Dis 2021 Mar 26. Epub 2021 Mar 26.

Segal Trials for Clinical Research, Miami, Florida, USA.

Background: Trichomonas vaginalis is the most prevalent non-viral sexually transmitted infection. We evaluated the efficacy and safety of secnidazole vs. placebo in women with trichomoniasis. Read More

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Chitosan-based systems aimed at local application for vaginal infections.

Carbohydr Polym 2021 Jun 6;261:117919. Epub 2021 Mar 6.

School of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, Brazil. Electronic address:

Vaginal administration is a promising route for the local treatment of infectious vaginal diseases since it can bypass the first-pass metabolism, drug interactions, and adverse effects. However, the commercial products currently available for topical vulvovaginal treatment have low acceptability and do not adequately explore this route. Mucoadhesive systems can optimize the efficacy of drugs administered by this route to increase the retention time of the drug in the vaginal environment. Read More

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Prevalence, risk factors and association with delivery outcome of curable sexually transmitted infections among pregnant women in Southern Ethiopia.

PLoS One 2021 24;16(3):e0248958. Epub 2021 Mar 24.

Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.

Introduction: Curable sexually transmitted infections (STIs) such as infection with Chlamydia trachomatis (C. trachomatis), Neisseria gonorrhoeae (N. gonorrhoeae), and Trichomonas vaginalis (T. Read More

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