8,276 results match your criteria Trichomoniasis


Adolescent Trichomonas vaginalis in a high-burdened region of the southern United States.

Sex Transm Dis 2020 May 20. Epub 2020 May 20.

Department of Pediatrics, Division of Developmental-Behavioral Pediatrics, Prisma Health Upstate, Greenville, SC.

Background: We evaluated the clinical management and risk factors for Trichomonas vaginalis-positive adolescents in upstate South Carolina.

Methods: An EPIC electronic medical record report was generated to identify any physician-ordered T. vaginalis test from February 2016 to December 2017 for patients aged 12-18 years within the Prisma Health Upstate system. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001186DOI Listing

Vaginal probiotic adherence and acceptability in Rwandan women with high sexual risk participating in a pilot randomised controlled trial: a mixed-methods approach.

BMJ Open 2020 May 19;10(5):e031819. Epub 2020 May 19.

Department of Clinical Infection, Microbiology and Immunology, Institute of Infection and Global Health, University of Liverpool, Liverpool, Merseyside, UK

Objectives: To evaluate adherence and acceptability of intermittent vaginal probiotic or antibiotic use to prevent bacterial vaginosis (BV) recurrence.

Design: Repeated adherence and acceptability assessments using mixed methods within a pilot randomised controlled trial.

Setting: Research clinic in Kigali, Rwanda. Read More

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http://dx.doi.org/10.1136/bmjopen-2019-031819DOI Listing

In Vitro Effect of Methanolic Extract of Argemone mexicana against Trichomonas vaginalis.

Korean J Parasitol 2020 Apr 30;58(2):135-145. Epub 2020 Apr 30.

Department of Chemistry, College of Biological Sciences, Autonomous University of Nuevo León, Nuevo León 66455, México.

Infections caused by Trichomonas vaginalis in humans are one of the main public health problems caused by sexually transmitted diseases. Objective of this study was to evaluate potential biological activity of the medicinal plant Argemone mexicana (Mexican poppy) on T. vaginalis. Read More

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http://dx.doi.org/10.3347/kjp.2020.58.2.135DOI Listing

Trichomoniasis in a tertiary hospital of Madrid, Spain (2013-2017): prevalence and pregnancy rate, coinfections, metronidazole resistance, and endosymbiosis.

Parasitol Res 2020 May 14. Epub 2020 May 14.

Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain.

Trichomoniasis is the most prevalent curable sexually transmitted infection (STI) worldwide and a risk factor for the acquisition of other STIs and adverse pregnancy outcomes. The objectives of this study were to determine the prevalence of T. vaginalis and related coinfections in women attending a third-level hospital of Madrid (Spain). Read More

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http://dx.doi.org/10.1007/s00436-020-06688-2DOI Listing

STI prevalence among women at risk for HIV exposure initiating safer conception care in rural, southwestern Uganda.

Sex Transm Dis 2020 May 13. Epub 2020 May 13.

Massachusetts General Hospital, Division of Infectious Diseases, Boston, MA.

Background: Knowledge of STI prevalence and risk factors is important to the development of tenofovir-based pre-exposure prophylaxis (PrEP) and safer conception programming. We introduced STI screening among women at risk for HIV exposure, participating in a safer conception study in southwestern Uganda.

Methods: We enrolled 131 HIV-uninfected women, planning for pregnancy with a partner living with HIV or of unknown HIV-serostatus (2018-2019). Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001197DOI Listing

Data showing differential expression of Monocyte chemoattractant protein-1 in response to symptomatic and asymptomatic infection.

Data Brief 2020 Jun 28;30:105628. Epub 2020 Apr 28.

Assistant Professor, Dr. B. R. Ambedkar Centre for Biomedical Research, University of Delhi, Delhi 110007, India.

Trichomoniasis is caused by (a protozoan parasite). About 80% of the infected cases remain asymptomatic [1]. The differential response of showing symptoms or no symptoms is not yet explored. Read More

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http://dx.doi.org/10.1016/j.dib.2020.105628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210420PMC

Assessment of STI screening in Romania using a multiplex PCR technique.

J Infect Dev Ctries 2020 Apr 30;14(4):341-348. Epub 2020 Apr 30.

Department of Cell and Molecular Biology, 'Iuliu Haţieganu' University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Introduction: Most sexually transmitted infections (STIs) are curable, but inappropriate treatment can lead to serious complications. The importance of setting up STI screening programs has been highlighted in various studies, the absence of such national programs accounting for the lack of STI statistics in Romania. The purpose of our study was to evaluate multiplex PCR as a screening method for the most common 6 STIs and establish their frequency in a group of symptomatic and asymptomatic patients. Read More

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http://dx.doi.org/10.3855/jidc.11989DOI Listing

Composite thermoresponsive hydrogel with auranofin-loaded nanoparticles for topical treatment of vaginal trichomonad infection.

Adv Ther (Weinh) 2019 Dec 30;2(12). Epub 2019 Oct 30.

Department of Medicine, University of California San Diego, La Jolla, California 92093, USA.

is responsible for the most common non-viral sexually-transmitted disease worldwide. Standard treatment is with oral nitro-heterocyclic compounds, metronidazole or tinidazole, but resistance to these drugs is emerging and adverse effects can be problematic. Topical treatment offers potential benefits for increasing local drug concentrations and efficacy, while reducing systemic drug exposure, but no topical strategies are currently approved for trichomoniasis. Read More

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http://dx.doi.org/10.1002/adtp.201900157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7202563PMC
December 2019

Development of a convenient detection method for Trichomonas vaginalis based on loop-mediated isothermal amplification targeting adhesion protein 65.

BMC Infect Dis 2020 May 1;20(1):319. Epub 2020 May 1.

Xinxiang Key Laboratory of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, Henan, 453003, People's Republic of China.

Background: Trichomoniasis resulting from Trichomonas vaginalis (T. vaginalis) has been considered as a commonly seen disease with the transmission way of sex. At present, the detection methods of T. Read More

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http://dx.doi.org/10.1186/s12879-020-05048-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195720PMC

Diagnosis and Treatment of Vaginal Discharge Syndromes in Community Practice Settings.

Clin Infect Dis 2020 Apr 30. Epub 2020 Apr 30.

Magee-Womens Research Institute, Pittsburgh, Pennsylvania, USA.

Background: Although vaginal symptoms are common, diagnosis of bacterial vaginosis (BV), vulvovaginal candidiasis (VVC), and Trichomonas vaginalis (TV) is not standardized. Diagnostic approaches and appropriateness of treatment were evaluated for women with symptoms of vaginitis who were seeking care at community practice sites.

Methods: Three hundred three symptomatic women, across 8 University of Pittsburgh Medical Center-affiliated clinics, were evaluated per standard office-based practice. Read More

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http://dx.doi.org/10.1093/cid/ciaa260DOI Listing

Prevalence of and risk factors for curable sexually transmitted infections on Bubaque Island, Guinea Bissau.

Sex Transm Infect 2020 Apr 28. Epub 2020 Apr 28.

Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.

Objectives: Complications from sexually transmitted infections (STIs) can result in severe morbidity and mortality. To date, no STI population studies have been conducted on the Bijagos Islands, Guinea Bissau. Our objective was to estimate the prevalence of and identify risk factors for and ) on Bubaque, the most populated island. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054351DOI Listing

The role of trust and health literacy in nurse-delivered point-of-care STI testing for pregnant women living with HIV, Tshwane District, South Africa.

BMC Public Health 2020 Apr 28;20(1):577. Epub 2020 Apr 28.

Charles R. Drew University of Medicine and Science, Los Angeles, CA, USA.

Background: Sexually transmitted infections (STIs) during pregnancy result in neonatal morbidity and mortality, and may increase mother-to-child-transmission of HIV. Yet the World Health Organization's current syndromic management guidelines for STIs leaves most pregnant women undiagnosed and untreated. Point-of-care (POC) diagnostic tests for STIs can drastically improve detection and treatment. Read More

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http://dx.doi.org/10.1186/s12889-020-08689-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189538PMC

Prevalence and correlated factors of sexually transmitted infections among women attending a Korean sexual assault center.

J Forensic Leg Med 2020 Apr 9;71:101935. Epub 2020 Mar 9.

Department of Laboratory Medicine, Seoul National University College of Medicine, 101, Daehak-ro, Jongno-gu, Seoul, 03080, South Korea; Department of Laboratory Medicine, Seoul National University Boramae Medical Center, 20, Borama-ro 5-gil, Dongjak-gu, Seoul, 07061, South Korea. Electronic address:

Long-term observation of the prevalence of sexually transmitted infections (STIs) is unclear in sexual assault victims (SAVs).We aimed to identify the trends in the prevalence of STIs in SAVs and factors correlated with STIs. Between January 2010 and May 2019, a retrospective observational study was conducted in a regional sexual assault center in Seoul. Read More

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http://dx.doi.org/10.1016/j.jflm.2020.101935DOI Listing

Association of Bartholin cysts and abscesses and sexually transmitted infections.

Am J Emerg Med 2020 Apr 15. Epub 2020 Apr 15.

Department of Emergency, Medicine Mayo Clinic, Jacksonville, FL, United States of America. Electronic address:

Introduction: Bartholin gland cysts or abscesses account for many gynecologic visits in the emergency department (ED). Previous smaller studies have suggested a link between Bartholin cysts/abscesses and sexually transmitted infections (STIs), but few studies have involved the ED.

Methods: We retrospectively identified patients aged 18 years or older seen in 1 ED between January 2012 and March 2017 who had urinalysis and urine culture and/or were tested for gonorrhea, chlamydia, or trichomonas by nucleic acid amplification testing. Read More

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http://dx.doi.org/10.1016/j.ajem.2020.04.027DOI Listing

Identification of High-Risk Pregnancies in a Remote Setting Using Ambulatory Blood Pressure: The MINDI Cohort.

Front Public Health 2020 24;8:86. Epub 2020 Mar 24.

School of Human Nutrition, Faculty of Agricultural and Environmental Sciences, McGill University (Macdonald Campus), Ste-Anne-de-Bellevue, QC, Canada.

Ambulatory blood pressure is a potential tool for early detection of complications during pregnancy, but its utility in impoverished settings has not been assessed. This cross-sectional study aimed to determine whether maternal infections, nutrient deficiencies and inflammation (MINDI) were associated with four measures of maternal blood pressure (BP) and to determine their association with symphysis-fundal-height (SFH). Environmental and dietary factors, intake of iron and a multiple-nutrient supplement (MNS), markers of inflammation, protein, anemia, folate, vitamins B, A and D status, and urogenital, skin, oral and intestinal nematode infections were measured in indigenous pregnant Panamanian women. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7121149PMC

Trichomonas vaginalis in Pregnancy: Patterns and Predictors of Testing, Infection, and Treatment.

Obstet Gynecol 2020 May;135(5):1136-1144

Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center, and the Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, Massachusetts; and the Emory University School of Medicine, and the Department of Gynecology and Obstetrics, the Division of Infectious Disease, Department of Medicine, and the Division of Family Planning, Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA.

Objective: To identify factors associated with testing for and diagnosis of trichomoniasis in pregnancy and to describe patterns of treatment and tests of reinfection or persistence.

Methods: We conducted a retrospective cohort study of women who delivered from July 2016 to June 2018 at one institution. Testing for Trichomonas vaginalis infection was done by wet mount microscopy or by nucleic acid amplification testing for routine prenatal testing or symptomatic visits. Read More

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http://dx.doi.org/10.1097/AOG.0000000000003776DOI Listing

Association between Vaginal Infections and the Types and Viral Loads of Human Papillomavirus: A Clinical Study Based on 4,449 Cases of Gynecologic Outpatients.

Can J Infect Dis Med Microbiol 2020 24;2020:9172908. Epub 2020 Mar 24.

Department of Laboratory Medicine, Shanxi Provincial People's Hospital, Taiyuan, China.

Objective: We here evaluated the association between human papillomavirus (HPV) infection and vaginal infections, including bacterial vaginosis (BV), trichomonas vaginalis (TV), and vulvovaginal candidiasis (VVC).

Methods: A total of 4,449 women were enrolled in this study and given gynecological examinations. HPV genotyping and viral load determination were performed using a real-time PCR. Read More

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http://dx.doi.org/10.1155/2020/9172908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7128038PMC
March 2020
0.487 Impact Factor

Influence of Sexually Transmitted Infections in Pregnant Adolescents on Preterm Birth and Chorioamnionitis.

Infect Dis Obstet Gynecol 2020 25;2020:1908392. Epub 2020 Mar 25.

Departments of Obstetrics and Gynecology and Global Health, University of Washington, USA.

Background: Adolescents have an increased risk of preterm birth (PTB) and sexually transmitted infections (STIs). We examined the prevalence and impact of STIs (gonorrhea, chlamydia, and trichomonas) on PTB and chorioamnionitis in pregnant adolescents.

Methods: This retrospective cohort study utilized the first pregnancy delivered at an urban hospital among patients ≤ 19 years old over a 5-year period. Read More

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http://dx.doi.org/10.1155/2020/1908392DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7132592PMC

Protozoan genital invasions caused by the representatives of trichomonas and giardia.

Wiad Lek 2020 ;73(2):380-383

State Еstablishment "Institute of Dermatology And Venereology of the National Academy of Medical Sciences of Ukraine", Kharkiv, Ukraine.

Objective: The aim was to perform systematic review of genitourinary protozoan invasion and analyze their pathogenicity and the ability to influence the genitourinary infections.

Patients And Methods: Materials and methods: For systematic review of papers the EMBASE and PubMed databases were searched. We also reviewed our own pilot studies using real-time polymerase chain reaction (PCR) to determine Trichomonas tenax, Pentatrichomonas hominis and Giardia lamblia. Read More

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Call to action for health systems integration of point-of-care testing to mitigate the transmission and burden of sexually transmitted infections.

Sex Transm Infect 2020 Apr 2. Epub 2020 Apr 2.

Department of Sexual and Reproductive Health and Research, WHO, Geneva, Switzerland.

Objectives: In 2016, WHO estimated 376 million new cases of the four main curable STIs: gonorrhoea, chlamydia, trichomoniasis and syphilis. Further, an estimated 290 million women are infected with human papillomavirus. STIs may lead to severe reproductive health sequelae. Read More

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http://dx.doi.org/10.1136/sextrans-2019-054358DOI Listing

[Sexually transmitted infections: gonococcal disease, chlamydia, syphilis, human papillomavirus, trichomonas].

Rev Prat 2019 Dec;69(10):e337-e350

Service de maladie infectieuse-dermatologie (CeGIDD), CHU de La Réunion site Sud, La Réunion, France.

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December 2019

Technologies, strategies and approaches for testing populations at risk of sexually transmitted infections: a systematic review protocol to inform prevention and control in EU/EEA countries.

Syst Rev 2020 Mar 25;9(1):64. Epub 2020 Mar 25.

London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, UK.

Objectives: This protocol outlines a systematic review methodology, aiming to assess the recent evidence-base for the impact of testing strategies and approaches on access to testing, testing coverage, and linkage to care for populations at risk for specific curable sexually transmitted infections (STIs) (chlamydia, gonorrhoea, syphilis, trichomoniasis, and Mycoplasma genitalium infections).

Data Sources: These include MEDLINE, Embase, PsycINFO, Global Health, Cochrane Database, Epistemonikos, CINAHL Plus, and Web of Science Core Collection.

Review Methods: Papers reporting primary data from 1 January 2012 onwards will be included. Read More

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http://dx.doi.org/10.1186/s13643-020-01303-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098083PMC

IL-6 produced by prostate epithelial cells stimulated with Trichomonas vaginalis promotes proliferation of prostate cancer cells by inducing M2 polarization of THP-1-derived macrophages.

PLoS Negl Trop Dis 2020 03 20;14(3):e0008126. Epub 2020 Mar 20.

Department of Environmental Biology and Medical Parasitology, Hanyang University College of Medicine, Seoul, Korea.

Trichomonas vaginalis (Tv), a protozoan parasite causing sexually-transmitted disease, has been detected in tissue of prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer (PCa). IL-6, a mediator of chronic inflammation, induces the progression of prostate cancer, and influences the polarization of M2 macrophages, which are the main tumor-associated macrophages. We investigated whether IL-6 produced by human prostate epithelial cells stimulated with Tv induces the M2 polarization of THP-1-derived macrophages, which in turn promotes the progression of PCa. Read More

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http://dx.doi.org/10.1371/journal.pntd.0008126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7138318PMC

Point-of-Care Testing to Guide Treatment and Estimate Risk Factors for Sexually Transmitted Infections in Adolescents and Young People With Human Immunodeficiency Virus in Eswatini.

Open Forum Infect Dis 2020 Mar 13;7(3):ofaa052. Epub 2020 Feb 13.

Baylor College of Medicine Children's Foundation, Mbabane, Eswatini.

Background: The World Health Organization (WHO) estimates 127 million new cases of (CT), 87 million new cases of (NG), and 156 million new cases of (TV) each year, which corresponds to 355 (219-606), 303 (216-468), and 243 (97.6-425) thousand disability-adjusted life-years. In low-resource settings, however, sexually transmitted infections (STIs) are treated syndromically and many individuals with asymptomatic infection may be missed, especially adolescents and young adults with human immunodeficiency virus (HIV). Read More

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http://dx.doi.org/10.1093/ofid/ofaa052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7071112PMC

HIV and other sexually transmitted infections among female sex workers in Moscow (Russia): prevalence and associated risk factors.

Sex Transm Infect 2020 Mar 18. Epub 2020 Mar 18.

Médecins du Monde, Paris, France.

To estimate the prevalence and factors associated with HIV and five other STIs among outdoor female sex workers (OSFW) and indoor FSW (IFSW).

Methods: Cross-sectional survey using respondent-driven sampling methodology. Participants answered a bio-behavioural questionnaire and were tested for (NG), (CT), (TV), syphilis (lifetime contact) and (MG). Read More

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http://dx.doi.org/10.1136/sextrans-2019-054299DOI Listing

HIV Testing Among Adolescents With Acute Sexually Transmitted Infections.

Pediatrics 2020 Apr 16;145(4). Epub 2020 Mar 16.

Craig Dalsimer Division of Adolescent Medicine and.

Background And Objectives: Rates of sexually transmitted infections (STIs) have increased over the decade. Guidelines recommend HIV testing with incident STIs. Prevalence and factors associated with HIV testing in acute STIs are unknown in adolescents. Read More

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http://dx.doi.org/10.1542/peds.2019-2265DOI Listing

The effect of iron on TvCP2: a cysteine proteinase found in vaginal secretions of trichomoniasis patients.

Parasitology 2020 Jun 16;147(7):760-774. Epub 2020 Mar 16.

Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), CP 07360, Mexico City, Mexico.

Trichomonas vaginalis (Tv) induces host cell damage through cysteine proteinases (CPs) modulated by iron. An immunoproteomic analysis showed that trichomoniasis patient sera recognize various CPs, also some of them are present in vaginal washes (VWs). Thus, the goal of this work was to determine whether TvCP2 is expressed during infection and to assess the effect of iron on TvCP2 expression, localization and contribution to in vitro cellular damage. Read More

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http://dx.doi.org/10.1017/S0031182020000438DOI Listing

No Pathogen-Specific Sign or Symptom Predicts the Etiology of Monomicrobial Nongonococcal Urethritis in Men.

Sex Transm Dis 2020 May;47(5):329-331

From the Departments of Medicine.

Identifying pathogen-specific signs or symptoms of nongonococcal urethritis could improve syndromic management accuracy. We evaluated nongonococcal urethritis signs and symptoms in 220 men with single-pathogen infections (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, or Ureaplasma urealyticum) or idiopathic urethritis. No individual sign or symptom accurately predicted the infectious etiology. Read More

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http://dx.doi.org/10.1097/OLQ.0000000000001158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7167349PMC

Design, Formulation, and Physicochemical Evaluation of Vaginal Cream Containing , and extracts for Prevention and Treatment of Trichomoniasis.

Int J Prev Med 2019 9;10:179. Epub 2019 Oct 9.

Novel Drug Delivery Systems Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Trichomoniasis is a common sexually transmitted disease that is caused by infection with protozoan parasite called . Metronidazole is the drug of choice for the treatment of this infection. In this study, design, formulation, and physicochemical evaluation of vaginal cream containing , and extracts for the prevention and treatment of trichomoniasis has been investigated. Read More

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http://dx.doi.org/10.4103/ijpvm.IJPVM_525_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826777PMC
October 2019

Recent Advances in the Development of Broad-Spectrum Antiprotozoal Agents.

Curr Med Chem 2020 Mar 3. Epub 2020 Mar 3.

Laboratorio de Biotecnología Farmacéutica, Centro de Biotecnología Genómica, Instituto Politecnico Nacional, Reynosa, 88710. Mexico.

Infections caused by Trypanosoma brucei, Trypanosoma cruzi, Leishmania spp., Entamoeba histolytica, Giardia lamblia, Plasmodium spp., and Trichomonas vaginalis, are part of a large list of human parasitic diseases. Read More

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http://dx.doi.org/10.2174/0929867327666200303170000DOI Listing
March 2020
3.853 Impact Factor

Developing a new drug against trichomoniasis, new inhibitory compounds of the protein triosephosphate isomerase.

Parasitol Int 2020 Jun 27;76:102086. Epub 2020 Feb 27.

Laboratorio de Investigación Bioquímica, Doctorado en Biotecnología ENMyH-Instituto Politécnico Nacional, Guillermo Massieu Helguera No. 239, La Escalera Ticomán, 07320 Ciudad de México, Mexico. Electronic address:

Trichomonas vaginalis is the protozoan parasite responsible for the most prevalent, non-viral, sexually transmitted disease, which affects millions of people around the world. The main treatment against this disease is metronidazole and some other nitroimidazole derivatives. However, between five and 20% of clinical cases of trichomoniasis are caused by parasites resistant to these drugs. Read More

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http://dx.doi.org/10.1016/j.parint.2020.102086DOI Listing

In Vitro Activity of and Its Main Essential Oil Component Trans-Anethole on .

Iran J Parasitol 2019 Oct-Dec;14(4):631-638

Department of Medical Parasitology and Mycology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Background: Trichomoniasis is one of the most common nonviral sexually transmitted infections worldwide which drug-resistant cases of the infection are rising. The aim of the study was to assessment the in vitro activity of and its main essential oil component on . Also phytochemical investigation of essential oil was performed. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7028236PMC
February 2020

The Chinese herbal prescription JZ-1 induces autophagy to protect against herpes simplex Virus-2 in human vaginal epithelial cells by inhibiting the PI3K/Akt/mTOR pathway.

J Ethnopharmacol 2020 May 20;254:112611. Epub 2020 Feb 20.

Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China; Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:

Ethnophamacological Relevance: The Chinese herbal prescription JieZe-1 (JZ-1) is based on the modification of Yihuang Tang, which was first described in Fu Qingzhu Nvke by the famous Qing Dynasty doctor Shan Fu as a treatment for leukorrheal diseases. As an in-hospital preparation, JZ-1 has been used in Tongji Hospital for many years to treat various infectious diseases of the lower female genital tract, including cervicitis, vaginitis, genital herpes and condyloma acuminatum. Our previous studies have shown that JZ-1 has curative effects on Candida albicans, Trichomonas vaginalis and Ureaplasma urealyticum infections. Read More

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http://dx.doi.org/10.1016/j.jep.2020.112611DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7126429PMC

T. vaginalis in riverside women in Amazonia, Brazil: an experience using the EVALYN® BRUSH vaginal self-collection device.

J Infect Dev Ctries 2019 11 30;13(11):1029-1037. Epub 2019 Nov 30.

Instituto de Saúde e Biotecnologia (ISB), Universidade Federal do Amazonas (UFAM), Coari, Amazonas, Brasil.

Introduction: The challenges related to the diagnosis of sexually transmitted infections present more complex factors in remote and hard-to-reach areas. The use of self-collection devices that facilitate the obtaining of a biological sample with high quality for sensitive molecular tests have been examined. This study aimed to evaluate the performance and acceptance of the Evalyn® Brush (Rovers® Medical Devices) for detection of T. Read More

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http://dx.doi.org/10.3855/jidc.11385DOI Listing
November 2019

The association between region of birth and sexually transmitted infections among people of black Caribbean ethnicity attending sexual health services in England, 2015.

PLoS One 2020 21;15(2):e0228654. Epub 2020 Feb 21.

National Infection Service, Public Health England, London, United Kingdom.

Background/introduction: In England, people of Black Caribbean (BC) ethnicity are disproportionately affected by sexually transmitted infections (STIs), but it is unclear whether this varies by their region of birth.

Aim(s)/objectives: To examine differences in STI diagnoses among UK- and Caribbean-born BC people.

Methods: Data on STI diagnoses in BC people attending specialist sexual health services (SHSs) during 2015 and living in England were obtained from the GUMCAD STI surveillance system, the national surveillance system for STIs in England. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0228654PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7034901PMC

Is genital tract infection related to tubal diseases in infertile Vietnamese women?

J Infect Dev Ctries 2019 10 31;13(10):906-913. Epub 2019 Oct 31.

Competence Centre on Health Technologies, Tartu, Estonia.

Introduction: The goal of this study was to identify the profile of genital tract infections and their relationship with clinical and demographic parameters as well as tubal diseases among infertile women in Vietnam.

Methodology: In this cross-sectional descriptive study, we enrolled 597 women undergoing infertility treatment at the Center for Reproductive Endocrinology and Infertility, Hue University Hospital, Vietnam. All of the study participants were interviewed and examined by a gynecologist. Read More

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http://dx.doi.org/10.3855/jidc.11632DOI Listing
October 2019

Prevalence and risk factors for infection in pregnant women in South Africa.

Int J STD AIDS 2020 Mar 19;31(4):351-358. Epub 2020 Feb 19.

School of Clinical Medicine Laboratory, College of Health Sciences, University of KwaZulu-Natal, Durban, South Africa.

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http://dx.doi.org/10.1177/0956462420907758DOI Listing

PCR Detection and Sequencing of Trichomonas vaginalis in Women with Suspected Vaginitis in the southwestern Iran.

Infect Disord Drug Targets 2020 Feb 18. Epub 2020 Feb 18.

Department of Obstetrics & Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz. Iran.

Introduction: The human being is considered a natural host for Trichomonas vaginalis (T. vaginalis), which causes trichomoniasis, the most frequent non-viral sexually transmitted infectious disease in the world. The current study aimed to evaluate the prevalence and sequencing of T. Read More

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http://dx.doi.org/10.2174/1871526520666200219110430DOI Listing
February 2020

[Evaluation of Microscopic Examination, Culture and Polymerase Chain Reaction Tests in the Diagnosis of Trichomonas vaginalis Infection].

Mikrobiyol Bul 2020 Jan;54(1):135-143

Akdeniz University Faculty of Medicine, Department of Medical Microbiology, Antalya, Turkey.

Sexually transmitted infections (STIs) are important as a public health problem all over the world. There are some difficulties in prevention and control programs of STIs due to clinical and laboratory diagnostic problems.The most common STIs are Chlamydia trachomatis infections, trichomoniasis and gonorrhea. Read More

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http://dx.doi.org/10.5578/mb.68828DOI Listing
January 2020

Diagnostic evaluation of the BD Affirm VPIII assay as a point-of-care test for the diagnosis of bacterial vaginosis, trichomoniasis and candidiasis.

Int J STD AIDS 2020 Mar 12;31(4):303-311. Epub 2020 Feb 12.

School of Clinical Medicine Laboratory, University of KwaZulu Natal, Durban, South Africa.

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http://dx.doi.org/10.1177/0956462419895684DOI Listing

Antiparasitic activity of furanyl N-acylhydrazone derivatives against Trichomonas vaginalis: in vitro and in silico analyses.

Parasit Vectors 2020 Feb 11;13(1):59. Epub 2020 Feb 11.

Laboratório de Biotecnologia Infecto-parasitária, Centro de Desenvolvimento Tecnológico, Biotecnologia, UFPel, Pelotas, RS, 96010-900, Brazil.

Background: Trichomonas vaginalis is the causative agent of trichomoniasis, which is one of the most common sexually transmitted diseases worldwide. Trichomoniasis has a high incidence and prevalence and is associated with serious complications such as HIV transmission and acquisition, pelvic inflammatory disease and preterm birth. Although trichomoniasis is treated with oral metronidazole (MTZ), the number of strains resistant to this drug is increasing (2. Read More

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http://dx.doi.org/10.1186/s13071-020-3923-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7014680PMC
February 2020

In vitro anti-Trichomonas vaginalis activity of Haplophyllum myrtifolium.

J Infect Dev Ctries 2019 03 31;13(3):240-244. Epub 2019 Mar 31.

Department of Microbiology, Faculty of Medicine, İzmir Katip Çelebi University, İzmir, Turkey.

Introduction: In the classic treatment of Trichomonas vaginalis infection, although metronidazole has been used since the 1960s, there has been an increase in MTZ-resistant T. vaginalis strains and failure in the treatment of trichomoniasis causes serious concerns. Therefore, the present study aimed to investigate the in vitro antitrichomonal activities of extracts (ethanol and total alkaloid) and pure compounds (chrysosplenetin, dictamnine, gamma-Fagarine, skimmianine) of H. Read More

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http://dx.doi.org/10.3855/jidc.10854DOI Listing

Pulmonary artery aneurysm rupture.

Autops Case Rep 2020 Jan-Mar;10(1):e2019131. Epub 2019 Dec 13.

Federal University of Espírito Santo (UFES), Department of Pathology, Hospital Universitário Cassiano Antônio Moraes (HUCAM), Unidade de Anatomia Patológica. Vitória, ES, Brazil.

Pulmonary artery aneurysm is a disorder of varying etiology and should be diagnosed early for appropriate interventions. A 45-year-old man was hospitalized for chest pain, dyspnea, cough, chills, diarrhea, and vomiting, which had started 3 weeks before admission. Physical examination indicated a reduced vesicular murmur in the right hemithorax. Read More

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http://dx.doi.org/10.4322/acr.2019.131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6945309PMC
December 2019

Bacterial vaginosis-associated vaginal microbiota is an age-independent risk factor for Chlamydia trachomatis, Mycoplasma genitalium and Trichomonas vaginalis infections in low-risk women, St. Petersburg, Russia.

Eur J Clin Microbiol Infect Dis 2020 Feb 8. Epub 2020 Feb 8.

WHO Collaborating Centre for Gonorrhoea and Other STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, SE-701 82, Örebro University, Örebro, Sweden.

The large majority of studies investigating associations between bacterial vaginosis (BV) and sexually transmitted infections (STIs) have been conducted among predominantly young women with high risk for STIs. Since a risky sexual behavior is a significant risk factor for both STIs and BV, this creates a bias toward an increased association between BV and STIs. This study evaluated associations between BV-associated vaginal microbiota and STIs (Chlamydia trachomatis, Mycoplasma genitalium, Trichomonas vaginalis, and Neisseria gonorrhoeae) in a population of women with low risk for STIs and investigated STI outcomes depending on the dominating Lactobacillus species. Read More

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http://dx.doi.org/10.1007/s10096-020-03831-wDOI Listing
February 2020

STI in times of PrEP: high prevalence of chlamydia, gonorrhea, and mycoplasma at different anatomic sites in men who have sex with men in Germany.

BMC Infect Dis 2020 Feb 7;20(1):110. Epub 2020 Feb 7.

Labor Krone/Labcon-OWL, Bad Salzuflen, Germany.

Background: Men who have sex with men (MSM) are disproportionally affected by sexually transmitted infections (STI). STI are often extragenital and asymptomatic. Both can delay diagnosis and treatment. Read More

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http://dx.doi.org/10.1186/s12879-020-4831-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7007644PMC
February 2020

Point-of-care testing and treatment of sexually transmitted infections to improve birth outcomes in high-burden, low-income settings: Study protocol for a cluster randomized crossover trial (the WANTAIM Trial, Papua New Guinea).

Wellcome Open Res 2019 22;4:53. Epub 2019 Mar 22.

The Kirby Institute for infection and immunity in society, UNSW Sydney, Sydney, NSW, 2052, Australia.

, , and bacterial vaginosis have been associated with preterm birth and low birth weight, and are highly prevalent among pregnant women in many low- and middle-income settings. There is conflicting evidence on the potential benefits of screening and treating these infections in pregnancy. Newly available diagnostic technologies make it possible, for the first time, to conduct definitive field trials to fill this knowledge gap. Read More

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http://dx.doi.org/10.12688/wellcomeopenres.15173.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6979472PMC

Multimodality Screening for Lower Genital Tract Infections Between 18 and 24 Weeks of Pregnancy and its Efficacy in Predicting Spontaneous Preterm Delivery.

J Obstet Gynaecol India 2020 Feb 15;70(1):36-43. Epub 2019 Oct 15.

1Department of Obstetrics and Gynecology, Kasturba Medical College, Manipal Academy of Higher Education (MAHE), Manipal, Karnataka India.

Background: Predicting spontaneous preterm birth (SPTB) during mid-trimester would be very useful. We used a multimodality screening approach mainly focusing on urogenital infections among unselected obstetric population between 18 and 24 weeks in a tertiary center.

Method: Diagnosis of lower genital tract infection (LGTI) was attempted among 228 pregnant women using several factors-symptom of vaginal discharge, characteristic appearance of discharge on speculum, point of care tests using Amsel's criteria and gram staining of vaginal swab. Read More

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http://dx.doi.org/10.1007/s13224-019-01287-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982619PMC
February 2020

History, Physical Examination, and Laboratory Findings Associated with Infection and the Empiric Treatment of Gonorrhea and Chlamydia of Women in the Emergency Department.

Cureus 2019 Dec 27;11(12):e6482. Epub 2019 Dec 27.

Emergency Medicine, University Hospitals Cleveland Medical Center, Cleveland, USA.

Background Neisseria gonorrhea (NG), Chlamydia trachomatis (CT), and Trichomonas vaginalis (TV) are common sexually transmitted infections (STIs) treated in the emergency department (ED). Objectives To assess the history, physical examination, and laboratory findings associated with NG and CT infection and the decision to administer empiric antibiotic treatment for the diseases in the ED. Methods A retrospective review of 566 clinical encounters of adult female patients tested for STIs between January 1, 2013 and December 31, 2014. Read More

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http://dx.doi.org/10.7759/cureus.6482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6984177PMC
December 2019