121 results match your criteria Trichofolliculoma


Collision Tumor between Trichofolliculoma and Melanocytic Nevus.

Int J Trichology 2017 Oct-Dec;9(4):181-183

Department of Pathology, Clínica Las Condes, Santiago, Chile.

Trichofolliculoma (TF) is a hamartomatous hair follicle-related tumor, clinically described as a dome-shaped papule with a central pore crossed by one or more silky white hairs. Histologically, it described as a cystic cavity containing keratinous debris, hair shaft fragments, and numerous hair follicles arising from its linings. Collision or compound tumors are a coexistence of two or more identifiable tumors in the same lesion. Read More

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November 2017
9 Reads

Solitary nodule with white hairs.

Cutis 2017 Aug;100(2):E1-E2

Department of Pathology and Laboratory Services, David Grant Medical Center, Fairfield, California, USA.

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Co-occurrence of steatocystoma multiplex, eruptive vellus hair cysts, and trichofolliculomas.

Cutis 2017 Jul;100(1):E23-E26

Department of Dermatology and the Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota, USA.

An association between steatocystoma multiplex (SCM) and eruptive vellus hair cysts (EVHCs) has been recognized. Steatocystoma multiplex and EVHC have similar clinical features but distinctive histologic features. Rare cases of co-occurrence of these conditions have been known to occur on the trunk and the forehead. Read More

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July 2017
7 Reads

Immunohistochemical dissection of cystic panfolliculoma focusing on the expression of multiple hair follicle lineage markers with an insight into the pathogenesis.

J Cutan Pathol 2017 Oct 24;44(10):861-866. Epub 2017 Jul 24.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

Panfolliculoma (PF) is a rare benign tumor with signs of differentiation toward all components of the hair follicle (HF). Cystic panfolliculoma (CPF) is a subset of PF with histological similarity to trichofolliculoma making the differential diagnosis difficult in some cases. Immunohistopathological investigations of PF have been reported; however, previous studies focused mostly on the expression profile of the outer root sheath markers. Read More

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October 2017
8 Reads

Chronological changes in trichofolliculoma: Folliculosebaceous cystic hamartoma is not a very-late-stage trichofolliculoma.

J Dermatol 2017 Sep 31;44(9):1050-1054. Epub 2017 Mar 31.

Division of Dermatology, Nakao Clinic, Saga, Japan.

Some authors have reported that the secondary hair follicles in trichofolliculomas (TF) undergo regressive changes and are subsequently replaced by the developed sebaceous elements, and that folliculosebaceous cystic hamartoma (FSCH) is a TF at a very late stage. In the present study, we revaluated the histopathological features of 40 TF lesions, focusing on their chronological changes. The results of the present study indicate that while the secondary follicles in the TF exhibited the hair cycle, the normal hair cycle was out of control, and tertiary hair follicles randomly developed from the involuting secondary follicles. Read More

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September 2017
6 Reads

Trichoadenoma of Nikolowski- A Rare Tumour with Unusual Presentation Over Vulva.

J Clin Diagn Res 2017 Jan 1;11(1):ED05-ED06. Epub 2017 Jan 1.

Associate Professor, Department of Pathology, Shaheed Hasan Khan Mewati, Government Medical College , Nalhar, Nuh, Haryana, India .

Trichoadenoma is a rare benign, slowly growing, cutaneous tumour of the hair follicle first described by Nikolowski in 1958. It presents as a non-specific nodule over the face or buttocks. However, unusual sites such as the neck, upper arm, thigh, shoulder, and shaft of the penis may also be affected. Read More

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January 2017
6 Reads

Genital folliculo-sebaceous cystic hamartoma: A claim of the stroma as a clue in the diagnosis of proliferations with follicular differentiation.

J Cutan Pathol 2017 May 8;44(5):504-508. Epub 2017 Mar 8.

Department of Dermatology, Fundación Jiménez Diaz, Universidad Autónoma, Madrid, Spain.

Folliculo-sebaceous hamartomas comprise a series of entities whose boundaries are imprecise. We present the clinical case of a folliculo-sebaceous cystic hamartoma of genital localization where the diagnosis was established based on the epithelial proliferation, but mostly, on the characteristic stroma. Because this lesion lacked of the cystic component, we mention the most frequent differential diagnoses and review the literature of the few cases published on this infrequent localization. Read More

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May 2017
13 Reads

Clinicopathologic study of 90 cases of trichofolliculoma.

J Eur Acad Dermatol Venereol 2017 Mar 18;31(3):e141-e142. Epub 2016 Sep 18.

Dermatopathology and Dermatology, Faculty of Medicine, University and University Hospital of Strasbourg, Strasbourg, France.

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March 2017
3 Reads

Dermoscopy of trichofolliculoma: a rare hair follicle hamartoma.

J Eur Acad Dermatol Venereol 2017 Feb 9;31(2):e123-e124. Epub 2016 Aug 9.

Hospital Universitario "Dr. José Eleuterio González", Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.

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February 2017
4 Reads

A Case of Late Stage Sebaceous Trichofolliculoma Showing Overlapping Features with Folliculosebaceous Cystic Hamartoma.

Ann Dermatol 2016 Aug 26;28(4):511-2. Epub 2016 Jul 26.

Department of Dermatology, College of Medicine, Kyung Hee University, Seoul, Korea.

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August 2016
3 Reads

Congenital Sebaceous Trichofolliculoma of the Upper Eyelid.

Ophthalmic Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S60-S61

*Emergency Department, and †Glaucoma Division, King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

A 6-year-old male presented with a protruding hair emerging from a temporally located nodule on his left upper eyelid 5mm above the eyelid margin since birth. The lesion was excised and sent to histopathology. The features were consistent with congenital sebaceous trichofolliculoma, a rare hamartomatous skin lesion. Read More

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June 2017
4 Reads

Hair Follicle Nevus Located on the Chin of an Infant: Case Report and Review of Literature.

Pediatr Dermatol 2016 Mar-Apr;33(2):e106-8

Department of Dermatology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina.

Hair follicle nevi are rare, benign, congenital hamartomas that usually occur in the distribution of the first brachial arch. Histopathologically, the distinction between hair follicle nevus, trichofolliculoma, and accessory tragus has recently come into question, and it may be that they are all on a spectrum of the same condition. We report the case of a 7-day-old boy who presented with a "tag"-like lesion on his midline chin that had been present since birth. Read More

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January 2017
3 Reads

Hair Follicle Nevus with Sebaceous Hyperplasia: A Dermoscopic Observation.

Case Rep Dermatol 2015 Sep-Dec;7(3):358-62. Epub 2015 Dec 23.

Department of Dermatology, Tokyo Medical University, Tokyo, Japan.

We herein report a case of hair follicle nevus, a rare hamartoma found on the face and showing follicular differentiation, which was associated with sebaceous hyperplasia. Dermoscopy of the lesion showed yellow globules surrounded by crown vessels/telangiectasias and scattered tiny hairs. Histopathological investigation revealed hyperplasia of the sebaceous glands and proliferation of well-differentiated vellus hair follicles. Read More

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March 2016
9 Reads

Benign follicular tumors.

An Bras Dermatol 2015 Nov-Dec;90(6):780-96; quiz 797-8

Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

Benign follicular tumors comprise a large and heterogeneous group of neoplasms that share a common histogenesis and display morphological features resembling one or several portions of the normal hair follicle, or recapitulate part of its embryological development. Most cases present it as clinically nondescript single lesions and essentially of dermatological relevance. Occasionally, however, these lesions be multiple and represent a cutaneous marker of complex syndromes associated with an increased risk of visceral neoplasms. Read More

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June 2016
14 Reads

Cutaneous Epithelial Lesions Induced by N-Methyl-N-nitrosourea in Male Sprague-Dawley Rats: A Possible Animal Model for Human Keratoacanthoma.

Anticancer Res 2016 Jan;36(1):111-20

Department of Dermatology, Meiwa Hospital, Nishinomiya, Hyogo, Japan.

A single intraperitoneal injection of 50 or 75 mg/kg N-methyl-N-nitrosourea in male Sprague-Dawley rats at 4 weeks of age, dose-dependently resulted in cutaneous epithelial cysts and tumors of pilosebaceous origin. Cysts were composed of epidermal cysts or mixed epidermal and inner root sheath hybrid cysts. The majority of induced tumors were keratoacanthomas. Read More

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January 2016
8 Reads

GATA3 Expression in Normal Skin and in Benign and Malignant Epidermal and Cutaneous Adnexal Neoplasms.

Am J Dermatopathol 2015 Dec;37(12):885-91

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA.

Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. Read More

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December 2015
73 Reads

Three different clinical faces of the same histopathological entity: hair follicle nevus, trichofolliculoma and accessory tragus.

An Bras Dermatol 2015 Jul-Aug;90(4):519-22

Çankiri State Hospital, Çankiri, TR.

Background: Hair follicle nevus is a rare, congenital hamartoma with follicular differentiation characterized histologically by numerous, tiny, mature hair follicles. Trichofolliculoma, the histopathological features of which are quite similar to those of hair follicle nevus, is also a hamartoma that differs from hair follicle. Accessory tragus is a relatively common, benign congenital abnormality of the external ear with an incidence rate of 1 to 10 per 1,000 live births. Read More

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March 2016
7 Reads

[Trichofolliculoma of the eyelid].

J Fr Ophtalmol 2015 Oct 23;38(8):780-1. Epub 2015 Jul 23.

Laboratoire d'anatomie et de cytologie pathologiques, CHU Farhat-Hached, 4002 Sousse Medina, Tunisie.

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October 2015
6 Reads

[Trichofolliculoma: a retrospective review of 8 cases].

Ann Dermatol Venereol 2015 Mar 13;142(3):183-8. Epub 2015 Feb 13.

Department of dermatology, allergology and venereal diseases, University of Helsinki and Helsinki University Central Hospital, Skin and allergy hospital, P.O.Box 160, 00029 HUS, Helsinki, Finlande.

Background: Trichofolliculoma is a rare benign tumor consisting of a pilosebaceous follicle hamartoma. While diagnosis of this condition is generally straightforward, fortuitous discovery of an atypical presentation can occur during histological examination of a biopsy or surgical sample.

Patients And Methods: We report herein on 8 patients aged between 8 and 75 years illustrating the wide spectrum of clinical presentation of this lesion, for which there are numerous differential diagnoses in the event of atypical clinical (lack of central whitish hair plug) or topical features (extra-facial site). Read More

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March 2015
3 Reads

[Trichofolliculoma of the scalp].

Ann Dermatol Venereol 2014 Nov 1;141(11):736-7. Epub 2014 Aug 1.

Service de dermatologie, hôpital Saint-André, 1, rue Burguet, 33075 Bordeaux cedex, France. Electronic address:

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November 2014
3 Reads

Sebaceous trichofolliculoma of the cheek in a 65-year-old man.

Pol J Pathol 2014 Oct;65(3):253-4

Asmaa Gaber Abdou, Faculty of Medicine, Pathology Department, Maxeem street, 002 Shebein Elkom, Egypt, e-mail:

Sebaceous trichofolliculoma is considered as hamartomatous lesion with follicular differentiation. In this study, we demonstrated a classic histopathologic picture of sebaceous trichofolliculoma in a 65-year-old male presented with large sized right cheek swelling. Read More

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October 2014
8 Reads

Pili multigemini/trichofolliculoma-like organoid nevus.

J Am Acad Dermatol 2014 Sep;71(3):e83-5

Department of Plastic and Reconstructive Surgery, University of Tennessee College of Medicine, Chattanooga, Tennessee.

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September 2014
3 Reads

Dermatoscopy of folliculosebaceous cystic hamartoma.

Dermatol Pract Concept 2014 Jul 31;4(3):47-9. Epub 2014 Jul 31.

Department of Dermatology, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.

A 29-year-old Japanese man presented to our institution with a nodule on his nose that had increased in size since childhood. Physical examination indicated the presence of an elastic, firm, pedunculated red nodule measuring 15 mm in size. Dermatoscopic examination of the nodule indicated a yellowish-white network, yellowish-orange dots/globules at its center, and a pinkish-white structureless peripheral area. Read More

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July 2014
4 Reads

Trichofolliculoma presenting as lobulated mass: a rare presentation.

Int J Trichology 2014 Jan;6(1):19-20

Department of Pathology, Maulana Azad Medical College, New Delhi, India.

Trichofolliculoma represents abortive differentiation of pluripotent skin cells toward hair follicles. We present a case of an adult female with lobulated mass involving the tip and dorsum of the nose for the last 15 years. The systemic and radiological examinations were noncontributory. Read More

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January 2014
5 Reads

Pygo2 regulates β-catenin-induced activation of hair follicle stem/progenitor cells and skin hyperplasia.

Proc Natl Acad Sci U S A 2014 Jul 30;111(28):10215-20. Epub 2014 Jun 30.

Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697; and

Understanding the epigenetic mechanisms that control the activation of adult stem cells holds the promise of tissue and organ regeneration. Hair follicle stem cells have emerged as a prime model to study stem cell activation. Wnt/β-catenin signaling controls multiple aspects of skin epithelial regeneration, with its excessive activity promoting the hyperactivation of hair follicle stem/progenitor cells and tumorigenesis. Read More

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July 2014
4 Reads

Solitary papule over scalp.

Dermatol Online J 2014 Apr 16;20(4):22334. Epub 2014 Apr 16.

Jawaharlal Institute of Postgraduate Medical Education and Research.

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma characterized by follicular, sebaceous, and mesenchymal elements. Folliculosebaceous cystic hamartoma is probably not as rare as previously thought and its inclusion in the differential diagnosis of asymptomatic skin colored papules or nodules is warranted, especially if it is present in the head and neck region. Read More

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April 2014
2 Reads

Tumours of the skin adnexa: a case series with focus on multiple segmental forms.

Pathologica 2013 Dec;105(6):337-41

Objective: Skin adnexal tumours (SAT) as a whole are rare tumours, and most of our current knowledge on SAT is from single case reports or small series focused on single histotypes. The purpose of this paper is to review a series of benign and malignant SAT diagnosed in a 20-year period.

Methods: All consecutive cases of SAT diagnosed between January 1992 and Dicember 2011 were retrieved. Read More

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December 2013
3 Reads

Pilar sheath acanthoma simulating basal cell carcinoma.

G Ital Dermatol Venereol 2014 Feb;149(1):155-6

Section of Oncologic Dermatology, Department of Surgery and Translational Medicine, University of Florence, Florence, Italy -

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February 2014
4 Reads

Various tumors in the nasal vestibule.

Int J Clin Exp Pathol 2013 15;6(12):2713-8. Epub 2013 Nov 15.

Department of Otolaryngology-Head and Neck Surgery, Ewha Womans University School of Medicine Seoul, Korea.

Various types of diseases can involve the nasal vestibule. Diagnosis and treatment of a nasal vestibular mass is often challenging due to the anatomical features of the nasal vestibule. Here, we present four cases with nasal vestibular masses. Read More

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August 2014
23 Reads

[Report of 4 cases with trichofolliculoma].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2013 Jun;48(6):517-8

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June 2013
2 Reads

Umbilicated nodule over eyebrow.

Dermatol Online J 2013 Sep 14;19(9):19622. Epub 2013 Sep 14.

Jawaharlal Institute of Postgraduate Medical Education and Research.

Trichofolliculoma is a pilosebaceous follicle hamartoma in which several hairs are formed within single pilosebaceous unit and protrude out of single orifice. Herein we report a 45-year-old woman with a trichofolliculoma of the eyebrow. Read More

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September 2013
4 Reads

Trichofolliculoma: a rare variant of hair follicle hamartoma.

Dermatol Online J 2013 Aug 15;19(8):19264. Epub 2013 Aug 15.

Government Hospital of Malatya.

Trichofolliculoma is a rare hair follicle hamartoma, which is often regarded as a hair follicle tumor. Mostly, it presents as a papule or nodule, involving the skin of the face and scalp area. A central, dilated keratin plugged ostium with vellus hair(s) is often present. Read More

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August 2013
14 Reads

Nevus lipomatosus cutaneous superficialis associated with trichofolliculoma on the lower leg.

Indian J Dermatol 2013 Jul;58(4):330

Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan. E-mail: u.ac.jp.

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July 2013
5 Reads

Trichofolliculoma.

Cutis 2012 Dec;90(6):284, 289-90

University of Kentucky Medical School, Lexington, USA.

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December 2012
2 Reads

Multiple trichofolliculomas on unusual sites: a case report and review of the literature.

Int J Dermatol 2013 Jan 29;52(1):87-9. Epub 2012 May 29.

Department of Dermatology, College of Medicine, Kyunghee University, Seoul, Korea.

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January 2013
2 Reads

Spectrum of cutaneous and soft tissue lesions in two Carney complex patients-adnexal induction versus authentic adnexal neoplasms.

Am J Dermatopathol 2012 Oct;34(7):729-36

Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.

Two unusual Carney complex patients are described. In one of them, several cutaneous biopsies revealed myxoid lesions that were rather more close to authentic adnexal neoplasms with myxoid stroma than to a "myxoma with an epithelial component." These included lesions resembling trichofolliculoma, infundibular cyst, and trichodiscoma. Read More

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October 2012
6 Reads

[Folliculosebaceous cystic hamartoma: anatomo-clinical study].

Ann Dermatol Venereol 2012 Jan 6;139(1):23-30. Epub 2011 Dec 6.

Clinique dermatologique, université de Strasbourg, hôpitaux universitaires de Strasbourg, France.

Background: Folliculosebaceous cystic hamartoma (FSCH) is a relatively recently described malformation with follicular and sebaceous components and a particular type of stroma with adipocytes. We conducted an anatomo-clinical study in order to clarify the clinical and histological characteristics of FSCH.

Materials And Methods: We included all cases of FSCH diagnosed between 1985 and February 2011 at our dermatopathology laboratory. Read More

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January 2012
4 Reads

Inhibition of BMP signaling in P-Cadherin positive hair progenitor cells leads to trichofolliculoma-like hair follicle neoplasias.

J Biomed Sci 2011 Dec 14;18:92. Epub 2011 Dec 14.

Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Background: Skin stem cells contribute to all three major lineages of epidermal appendages, i.e., the epidermis, the hair follicle, and the sebaceous gland. Read More

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December 2011
8 Reads

Folliculosebaceous cystic hamartoma in a patient with neurofibromatosis type I.

Ann Dermatol 2011 Oct 31;23(Suppl 2):S185-7. Epub 2011 Oct 31.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

Folliculosebaceous cystic hamartoma (FSCH) is a rare cutaneous hamartoma composed of dilated folliculosebaceous units and mesenchymal elements. It presents as a papule or nodule usually on the face and scalp, rarely on the genital or trunk area. Histologically, FSCH shares several similar features to sebaceous trichofolliculoma. Read More

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October 2011
2 Reads

MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes.

J Cell Sci 2011 Oct 7;124(Pt 20):3399-404. Epub 2011 Oct 7.

Centre for Skin Sciences, School of Life Sciences, University of Bradford, Richmond Road, Bradford, BD7 1DP, UK.

Bone morphogenetic proteins (BMPs) play essential roles in the control of skin development, postnatal tissue remodelling and tumorigenesis. To explore whether some of the effects of BMP signalling are mediated by microRNAs, we performed genome-wide microRNA (miRNA) screening in primary mouse keratinocytes after BMP4 treatment. Microarray analysis revealed substantial BMP4-dependent changes in the expression of distinct miRNAs, including miR-21. Read More

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October 2011
9 Reads

Perifollicular nodule on the face of a young man.

Indian J Dermatol Venereol Leprol 2011 Jul-Aug;77(4):531-3

Department of Dermatology, Venereology, and Leprosy, R. G. Kar Medical College, Kolkata, India.

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May 2012
10 Reads
1 PubMed Central Citation(source)
1.320 Impact Factor

Hematologic, serologic, and histologic profile of aged Siberian hamsters (Phodopus sungorus).

J Am Assoc Lab Anim Sci 2011 May;50(3):308-16

Department of Comparative Medicine, School of Medicine, Stanford University, Stanford, California, USA.

Biologic samples from 18 (12 female, 6 male) Siberian hamsters (Phodopus sungorus) representing an aged colony (17 to 27 mo) were examined. Values for CBC and serum biochemical parameters were determined, and macroscopic and microscopic pathologic evaluations were performed. Blood urea nitrogen levels were significantly higher in male (54. Read More

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May 2011
3 Reads

Nevus lipomatosus superficialis with a folliculosebaceous component: report of 2 cases.

Patholog Res Int 2011 Apr 18;2011:105973. Epub 2011 Apr 18.

Department of Pathology, Hospital Universitario de Fuenlabrada, Camino del Molino 2, 28942 Fuenlabrada, Madrid, Spain.

Nevus lipomatosus superficialis (NLS) is an uncommon hamartomatous lesion of the skin characterized by the presence of clusters of mature fat cells among the collagen bundles of the dermis. Usually, the number of adnexal structures is reduced in NLS as compared to the normal adjacent skin, but their morphology is not altered. Nevertheless, in some instances, associated pilar abnormalities have been reported. Read More

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April 2011
3 Reads

Alteration of the β-catenin pathway in spiradenoma.

J Cutan Pathol 2011 Aug 26;38(8):657-62. Epub 2011 Apr 26.

Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea.

Background: Although skin carcinogenesis has been widely investigated, only limited information is available for epidermal tumors, while even less is known about other skin structures. Alterations in the β-catenin pathway have been reported in several epidermal tumors, while little is known about in adnexal tumors. This study was performed to assess alterations in the β-catenin pathway associated with adnexal tumors, and to investigate the mechanisms underlying these alterations. Read More

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August 2011
37 Reads

CD10 for the distinct differential diagnosis of basal cell carcinoma and benign tumours of cutaneous appendages originating from hair follicle.

Pol J Pathol 2010 ;61(3):140-6

Department of Pathology, Prof. Dr. A. Ilhan Ozdemir State Hospital, Giresun, Turkey.

Aims: Differential diagnosis between the group of trichoadenoma, trichofolliculoma, trichoepithelioma, trichoblastoma and basal cell carcinoma has been creating some difficulties for the pathologist and the clinicians, particularly in the presence of small specimens.

Material And Methods: A total of 30 cases of benign tumours of cutaneous appendages originating from the hair follicle and 30 cases of basal cell carcinoma were retrieved from the archives deposited from 2004 to 2008.

Results: The expression of CD10 in both tumours was graded from [0] to [2+] for each case. Read More

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June 2011
6 Reads

A revaluation of folliculosebaceous cystic hamartoma: the histopathological and immunohistochemical features.

Am J Dermatopathol 2010 Apr;32(2):154-61

Department of Internal Medicine, Saga University, Japan.

The histogenesis of folliculosebaceous cystic hamartoma (FSCH), including the origin of the frequently associated adipocytes and other mesenchymal components, remains unclear. There are controversial problems regarding FSCH, such as the relationship between FSCH and trichofolliculoma (TF), and the exact concept of sebaceous TF. Fourteen FSCHs and 1 sebaceous TF were revaluated for the histopathology and studied for immunohistochemical profile of various cytokeratins, hair follicular stem cell markers, and others. Read More

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April 2010
3 Reads

A revaluation of trichofolliculoma: the histopathological and immunohistochemical features.

Am J Dermatopathol 2010 Feb;32(1):35-43

Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Saga University, Nabeshima, Saga, Japan.

Few investigations on the histopathology of trichofolliculoma (TF) have so far included an immunohistochemical study. To seek new insight into TF with a revaluation of the histopathological features and an investigation of the immunohistochemical profile, 14 TFs were revaluated for the histopathology and the immunohistochemical profile of various cytokeratins (CKs), hair follicle stem cell markers, and others. The CK15 expression was upregulated in the basal cells from the primary cystic structures beyond to secondary follicles without expression of CK19. Read More

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February 2010
2 Reads

Bone morphogenetic protein antagonist noggin promotes skin tumorigenesis via stimulation of the Wnt and Shh signaling pathways.

Am J Pathol 2009 Sep 21;175(3):1303-14. Epub 2009 Aug 21.

Centre for Skin Sciences, School of Life Sciences, University of Bradford, Bradford, UK.

Bone morphogenetic proteins (BMPs) play pivotal roles in the regulation of skin development. To study the role of BMPs in skin tumorigenesis, BMP antagonist noggin was used to generate keratin 14-targeted transgenic mice. In contrast to wild-type mice, transgenic mice developed spontaneous hair follicle-derived tumors, which resemble human trichofolliculoma. Read More

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September 2009
9 Reads