539 results match your criteria Trichoepithelioma


Desmoplastic Trichoepithelioma With Pseudocarcinomatous Hyperplasia: A Folliculosebaceous Neoplasm in Young Persons.

Am J Dermatopathol 2021 Apr 21. Epub 2021 Apr 21.

UCSF Dermatopathology and Oral Pathology Service, University of California San Francisco, San Francisco, CA; Departments of Pathology and Dermatology, University of California San Francisco, San Francisco, CA; Department of Dermatology, Yale University School of Medicine, New Haven, CT; and Helen Diller Family Cancer Center, University of California San Francisco, San Francisco, CA.

Abstract: Pseudocarcinomatous desmoplastic trichoepithelioma (PDTE) features verrucous squamous epidermal hyperplasia with a jagged undersurface overlying cords of follicular germinative cells in a fibrotic stroma. To date, only 5 cases have been reported. We identified 7 new PDTEs from 2 institutions and reviewed their clinical manifestations and immunohistochemical profile. Read More

View Article and Full-Text PDF

Expression of Hedgehog signalling molecules in microcystic adnexal carcinoma.

Clin Exp Dermatol 2021 Mar 13. Epub 2021 Mar 13.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurances, Ruhr-University Bochum (IPA), Bochum, Germany.

Background: Microcystic adnexal carcinoma (MAC) is a rare skin neoplasm that has not been characterized on a molecular basis.

Aim: To assess expression profiles of Hedgehog (HH) signalling molecules in MAC and control tumours.

Methods: Immunohistochemistry was performed for Sonic Hedgehog (SHH), Indian Hedgehog (IHH), Patched 1 (PTCH1) and Smoothened (SMO) on patient MAC tissue (n = 26) and control tumour tissue, including syringoma (SyG; n = 11), trichoepithelioma (TE; n = 11) and basal cell carcinoma (BCC; n = 12) tissues. Read More

View Article and Full-Text PDF

Skin tumors in xeroderma pigmentosum: Evaluation of a large series and a literature review.

J Cutan Pathol 2021 Feb 11. Epub 2021 Feb 11.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Xeroderma pigmentosum (XP) is a rare genodermatosis with a lifelong propensity to develop malignant skin tumors.

Methods: In this retrospective study, 24 XP patients were evaluated with regard to frequency and clinicopathological features of benign and malignant skin tumors.

Results: Seventeen patients had at least one malignant skin tumor diagnosed: basal cell carcinoma (BCC) in 13 patients (n = 72), basosquamous carcinoma in three patients (n = 4), squamous cell carcinoma in six patients (n = 13), keratoacanthoma in three patients (n = 15), and melanoma in six patients (n = 18). Read More

View Article and Full-Text PDF
February 2021

Multiple rubbery nodules on the scalp.

JAAD Case Rep 2021 Feb 5;8:80-82. Epub 2021 Jan 5.

DiSSal Section of Dermatology, San Martino Polyclinic Hospital IRCCS, University of Genoa, Genoa, Italy.

View Article and Full-Text PDF
February 2021

Management of multiple trichoepithelioma: A review of pharmacological therapies.

Australas J Dermatol 2021 Jan 5. Epub 2021 Jan 5.

Department of Dermatology, Mater Misericordiae Health Services, Brisbane, Queensland, Australia.

Trichoepithelioma is a rare benign adnexal neoplasm that can occur in various forms including solitary, multiple, familial or nonfamilial. Multiple facial trichoepithelioma can be associated with significant psychosocial burden. Conventional treatment modalities such as surgical excision and ablative laser have variable results and can be associated with unacceptable complications and tumour regrowth. Read More

View Article and Full-Text PDF
January 2021

Morphologically high-grade trichoblastic carcinoma: a clinicopathological study with long-term clinical follow-up.

Histopathology 2021 Jun 6;78(7):970-975. Epub 2021 Apr 6.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Aims: Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterised by malignant transformation of a pre-existing benign trichoblastoma, and are subdivided histologically into low-grade and high-grade tumours. Whereas morphologically low-grade trichoblastic carcinomas show indolent behaviour, morphologically high-grade trichoblastic carcinomas have been associated with a poor prognosis, but little is known about their true biological potential. The aim of this study was to better define the clinicopathological features and outcomes of morphologically high-grade trichoblastic carcinomas. Read More

View Article and Full-Text PDF

Glioma-Associated Oncogene-1 Expression in Basal Cell Carcinoma and Its Histologic Mimics.

Am J Dermatopathol 2020 Dec 1. Epub 2020 Dec 1.

Departments of Pathology.

Basal cell carcinoma (BCC) is the most common skin cancer, and it has numerous histologic mimics with variable prognoses and treatments. Although some immunohistochemical stains can be used for the differential diagnosis of BCC, variability and overlap in results can complicate their interpretation. Immunohistochemical staining for glioma-associated oncogene-1 (Gli-1) was performed on 26 nodular BCCs, 22 infiltrative BCCs, 9 basaloid squamous cell carcinomas, 12 desmoplastic trichoepitheliomas, 19 Merkel cell carcinomas, 11 sebaceous carcinomas, 10 cylindromas, 14 spiradenomas, 12 adenoid cystic carcinomas (AdCC), and 1 solitary trichoepithelioma. Read More

View Article and Full-Text PDF
December 2020

A de novo missense mutation of the CYLD gene with multiple familial trichoepithelioma.

Clin Exp Dermatol 2020 Nov 20. Epub 2020 Nov 20.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

View Article and Full-Text PDF
November 2020

Brooke-Spiegler Syndrome With Cervical Spine Lesion.

Cureus 2020 Oct 16;12(10):e10982. Epub 2020 Oct 16.

Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, USA.

Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distant metastasis are scarce. We present the first case of Brooke-Spiegler syndrome with metastasis to the cervical spine. Read More

View Article and Full-Text PDF
October 2020

Collision Tumor in the Lower Eyelid: Basal Cell Carcinoma Adjacent to Trichoepithelioma.

Ophthalmic Plast Reconstr Surg 2020 Oct 16. Epub 2020 Oct 16.

From the Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology and Visual Sciences, Federal University of S. Paulo, S. Paulo, SP, Brazil.

View Article and Full-Text PDF
October 2020

Treatment of Brooke-Spiegler Syndrome Trichoepitheliomas with Erbium: Yttrium-Aluminum-Garnet Laser: A Case Report and Review of the Literature.

J Clin Aesthet Dermatol 2020 Jul 1;13(7):41-44. Epub 2020 Jul 1.

All authors are with the Department of Dermatology, University of California, Irvine, in Irvine, California.

Patients with Brooke-Spiegler Syndrome (BSS) can present with benign cylindromas, spiradenomas, spiradenocylindromas, and trichoepithelioma. Therapy options include excision, electrocautery, CO laser ablation, dermabrasion, and radiofrequency. Here, we present a patient with BSS with multiple trichoepitheliomas who was successfully treated with erbium:yttrium-aluminum-garnet (YAG) laser therapy and review similar cases of BSS treated with a YAG laser modality. Read More

View Article and Full-Text PDF

Clinical, Histopathological, and Management Challenges of Multiple Familial Trichoepithelioma: A Case Report of a Patient Presenting with Multiple Facial Papules.

Case Rep Dent 2020 7;2020:5648647. Epub 2020 Sep 7.

Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

Trichoepitheliomas (TE) are benign skin tumours of the pilosebaceous apocrine unit with follicular differentiation. Multiple familial trichoepithelioma (MFT) is a considerably rare condition inherited in an autosomal dominant pattern. We present a case of a 15-year-old male who presented with multiple papulo-nodular lesions in the central face and a family history of a similar type of lesions from his mother. Read More

View Article and Full-Text PDF
September 2020

Desmoplastic Trichoepithelioma: Histopathologic and Immunohistochemical Criteria for Differentiation of a Rare Benign Hair Follicle Tumor From Other Cutaneous Adnexal Tumors.

Cureus 2020 Aug 12;12(8):e9703. Epub 2020 Aug 12.

Pathology, South Bend Medical Foundation, South Bend, USA.

Desmoplastic trichoepitheliomas (DTEs) are benign cutaneous neoplasms that originate from the hair follicle and exhibit a preference for the facial region. This type of neoplasm is characterized by accelerated growth, with vigorous histologic and immunohistochemical features that may be confused with other skin cancers. Thus, the objective of this study is to establish a definitive diagnosis that can be widely used. Read More

View Article and Full-Text PDF

Differentiation of Basal Cell Carcinoma and Trichoepithelioma: An Immunohistochemical Study.

Am J Dermatopathol 2021 Mar;43(3):191-197

Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR; and.

Abstract: Basal cell carcinoma (BCC) is the most common malignancy of the skin. It is an epithelial neoplasm with origin in the precursor cells of the interfollicular epidermis. Even though it has low metastatic potential, delay in management may lead to local destruction and morbidity. Read More

View Article and Full-Text PDF

A novel large deletion of the CYLD gene causes CYLD cutaneous syndrome in a Chinese family.

Mol Genet Genomic Med 2020 10 11;8(10):e1441. Epub 2020 Aug 11.

Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Background: CYLD cutaneous syndrome (CCS; syn. Brooke-Spiegler syndrome) is a rare autosomal dominant hereditary disease characterized by multiple adnexal skin tumors including cylindromas, spiradenomas, and trichoepitheliomas. More than 100 germline mutations of the cylindromatosis (CYLD) gene have been reported in CCS and most of them are frameshift mutations or small alterations. Read More

View Article and Full-Text PDF
October 2020

Trichoepithelioma.

J Am Osteopath Assoc 2020 Aug 6. Epub 2020 Aug 6.

View Article and Full-Text PDF

Trichoepithelioma: Reflectance confocal microscopy features and dermoscopic features.

Skin Res Technol 2021 Mar 23;27(2):283-284. Epub 2020 Jul 23.

Department of Dermatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhenzhou University, Zhengzhou, China.

View Article and Full-Text PDF

Basal cell carcinoma misdiagnosed as trichoepithelioma.

Arch Craniofac Surg 2020 Jun 29;21(3):202-205. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Trichoepithelioma is a benign hair follicle tumor that can undergo malignant transformation into basal cell carcinoma in rare cases. Due to the similar clinical and histological features of trichoepithelioma and basal cell carcinoma, distinguishing between these types of tumors can be a diagnostic challenge. Punch biopsy obtains only a small sample of the entire lesion, and thus inherently involves a risk of misdiagnosis between histologically similar diseases. Read More

View Article and Full-Text PDF

Collision tumor of microcystic adnexal carcinoma and squamous cell carcinoma discovered on Mohs sections.

JAAD Case Rep 2020 Jun 18;6(6):479-481. Epub 2020 Apr 18.

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas.

View Article and Full-Text PDF

Are clinicians successful in diagnosing cutaneous adnexal tumors? a retrospective, clinicopathological study

Turk J Med Sci 2020 06 23;50(4):832-843. Epub 2020 Jun 23.

Department of Dermatology, Göztepe Training and Research Hospital, İstanbul Medeniyet University, İstanbul, Turkey

Background/aim: Cutaneous adnexal tumors (CAT) are rare tumors originating from the adnexal epithelial parts of the skin. Due to its clinical and histopathological characteristics comparable with other diseases, clinicians and pathologists experience difficulties in its diagnosis.We aimed to reveal the clinical and histopathological characteristics of the retrospectively screened cases and to compare the prediagnoses and histopathological diagnoses of clinicians. Read More

View Article and Full-Text PDF

Hidradenoma Papilliferum: Everyone Else's Diagnosis.

Indian J Dermatol 2020 Mar-Apr;65(2):151-153

Department of Dermatology, Rutgers-New Jersey Medical School, Newark, New Jersey, USA.

A 52-year-old female presented with an asymptomatic cyst-like lesion on her right labia majora present for several years. Excision revealed a 3-mm cystic lesion containing complex networks of thin fronds of clear apocrine cells and basaloid cells, features characteristic of hidradenoma papilliferum (HP). In contrast to the medical literature, the lesion was connected to the overlying epithelium by a straight duct, a feature characteristic of apocrine glands. Read More

View Article and Full-Text PDF

[Anatomoclinical and dermatoscopic study of trichoadenoma].

Ann Dermatol Venereol 2020 May 19;147(5):334-339. Epub 2020 Feb 19.

Clinique dermatopathologique, hôpitaux universitaires de Strasbourg, 67000 Strasbourg, France.

Introduction: Trichoadenoma is a very rare follicular tumour with a remarkable histopathological appearance. In this article we present a series of 12 cases of trichoadenoma, as well as the anatomoclinical and dermatoscopic findings in a typical case. We discuss these findings in the light of an extensive literature research. Read More

View Article and Full-Text PDF

[Giant trichilemmal carcinoma of the retroauricular: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2020 Jan;34(1):83-85

The trichilemmal carcinoma is a rare tumor that usually occurs on sun-exposed skin, especially on the face, scalp, neck and back of hands, mainly in elderly subjects but commonly between the 4th and 9th decades of life. We report a case of giant trichilemmal carcinoma. A 65-year-old man presented with a 5-year history of a slowly developing mass arising from his right retroauricular region, with local destruction of the auricle. Read More

View Article and Full-Text PDF
January 2020

First Japanese case of trichoepithelioma papulosum multiplex successfully treated with sirolimus gel.

J Dermatol 2020 May 20;47(5):e197-e198. Epub 2020 Feb 20.

Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.

View Article and Full-Text PDF

Desmoplastic Trichoepithelioma: An Uncommon but Diagnostically Problematic Benign Adnexal Tumor.

Acta Dermatovenerol Croat 2019 Dec;27(4):282-284

Vladimír Bartoš, MD, PhD, MPH, Deapartment of Pathology Faculty Hospital in Žilina, Vojtecha Spanyola 43, 012 07 Žilina, Slovakia;

Dear Editor, I read an interesting recent article by Karimzadeh et al. (1) in an earlier issue of your journal, who provided a comprehensive review addressing a relatively rare benign tumor originating from the hair follicles - trichoepithelioma (TE). They rightly claimed that trichoepithelioma can be divided into the following 3 subgroups: a) multiple familiar TE, b) solitary non-hereditary TE, and c) desmoplastic trichoepithelioma (DTE). Read More

View Article and Full-Text PDF
December 2019

A novel nonsense mutation of the CYLD gene in a Turkish family with multiple familial trichoepithelioma.

Clin Exp Dermatol 2020 Jun 13;45(4):508-511. Epub 2019 Dec 13.

Departments of, Department of, Dermatology and Venereology, Faculty of Medicine, Trakya University, Edirne, Turkey.

View Article and Full-Text PDF

A large family with CYLD cutaneous syndrome: medical genetics at the community level.

J Community Genet 2020 Jul 3;11(3):279-284. Epub 2019 Dec 3.

Post-graduate Program in Genetics and Molecular Biology, Department of Biosciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, 91501-970, Brazil.

Germline mutations in the cylindromatosis gene (CYLD) are associated with a rare autosomal dominant disease known as CYLD cutaneous syndrome (CCS). Patients present multiple neoplasms originating from skin appendages. Here, we investigated the main clinical and molecular features of a large family with CCS having lived in a small Brazilian town for 6 generations, making its prevalence significantly high. Read More

View Article and Full-Text PDF

State of the art of Mohs surgery for rare cutaneous tumors in the Spanish Registry of Mohs Surgery (REGESMOHS).

Int J Dermatol 2020 Mar 28;59(3):321-325. Epub 2019 Nov 28.

Hospital La Paz, Madrid, Spain.

Background: The use of Mohs micrographic surgery (MMS) for rare cutaneous tumors is poorly defined. We aim to describe the demographics, tumor presentation and topography, surgery characteristics and complications of MMS for rare cutaneous tumors in a national registry.

Methods: Prospective cohort study of patients treated with MMS in Spain between July 2013 and June 2018. Read More

View Article and Full-Text PDF