Search Our Scientific Publications & Authors

World J Surg Oncol 2022 May 4;20(1):142. Epub 2022 May 4.

Department of Pathology, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, No. 32, West Second Section, First Ring Road, Chengdu, 610072, China.

Background: Microcystic adnexal carcinoma (MAC) is a skin cancer with challenges in diagnosis and management. This study was aimed to detect molecular alterations of MAC and guide its pathologic diagnosis and treatment.

Methods: We performed transcriptome analysis on 5 MAC and 5 normal skin tissues, identified the differentially expressed genes, and verified them by immunohistochemistry. Read More

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 May;36(5):389-390

Department of Otorhinolaryngology Head and Neck Surgery，Dalian Central Hospital，Dalian，116033，China.

Trichoepithelioma is a kind of rare benign tumor of the skin that occurs in direct sunlight and is usually small. Large solitary trichoepithelioma behind the ear is rare. The pathological result of this patient was fibroproliferative trichoepithelioma. Read More

Animals (Basel) 2022 Apr 8;12(8). Epub 2022 Apr 8.

Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego St. 13, 10-719 Olsztyn, Poland.

Since small mammals are gaining popularity as pets in Poland, the number of tumour samples submitted for histopathological examination is quite high. This study was a retrospective analysis of cutaneous and subcutaneous tumours in small pet mammals submitted for histopathology in 2014-2021. The analysis included 256 tumours sampled from 103 guinea pigs, 53 rats, 43 pet rabbits, 21 ferrets, 17 hamsters, 8 degus, 5 African pygmy hedgehogs, 3 Mongolian gerbils and 3 chinchillas. Read More

Appl Immunohistochem Mol Morphol 2022 Apr;30(4):273-277

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center.

Background: The distinction among cutaneous basaloid neoplasms such as trichoepithelioma (TE), desmoplastic trichoepithelioma (DTE), morpheaform basal cell carcinoma (MBCC), and microcystic adnexal carcinoma (MAC) can be difficult, especially in superficial biopsies. As the treatment plan of each entity is different, accurate characterization is important for appropriate management. While TE and DTE are benign neoplasms with indolent behavior, MBCC and MAC are typically locally aggressive. Read More

Indian J Dermatol 2021 Nov-Dec;66(6):706

Department of Dermatology, Venereology and Leprology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

Indian J Dermatol Venereol Leprol 2022 Jan 20:1-2. Epub 2022 Jan 20.

Department of Dermatology, Venereology and Leprology, Pondicherry Institute of Medical Sciences, Puducherry, India.

Am J Dermatopathol 2022 Mar;44(3):190-195

Department of Dermatology, University of São Paulo, São Paulo, Brazil.

Abstract: Cutaneous adnexal tumors are benign and malignant neoplasms that undergo morphological differentiation into cutaneous adnexa, comprising pilosebaceous, eccrine, or apocrine units. Reflectance confocal microscopy is a noninvasive diagnostic method that enables in vivo visualization of tissues at a similar resolution as conventional histopathology. The use of this method in skin imaging over the past several years has improved dermatological diagnoses, potentiating its wide application, especially for benign and malignant skin tumors. Read More

J Dermatol 2022 Feb 29;49(2):e55-e56. Epub 2021 Oct 29.

Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan.

Int J Mol Sci 2021 Jul 8;22(14). Epub 2021 Jul 8.

Department of Basic Medical Sciences, Faculty of Medicine, University of La Laguna, 38071 Tenerife, Spain.

We studied CD34+ stromal cells/telocytes (CD34+SCs/TCs) in pathologic skin, after briefly examining them in normal conditions. We confirm previous studies by other authors in the normal dermis regarding CD34+SC/TC characteristics and distribution around vessels, nerves and cutaneous annexes, highlighting their practical absence in the papillary dermis and presence in the bulge region of perifollicular groups of very small CD34+ stromal cells. In non-tumoral skin pathology, we studied examples of the principal histologic patterns in which CD34+SCs/TCs have (1) a fundamental pathophysiological role, including (a) fibrosing/sclerosing diseases, such as systemic sclerosis, with loss of CD34+SCs/TCs and presence of stromal cells co-expressing CD34 and αSMA, and (b) metabolic degenerative processes, including basophilic degeneration of collagen, with stromal cells/telocytes in close association with degenerative fibrils, and cutaneous myxoid cysts with spindle-shaped, stellate and bulky vacuolated CD34+ stromal cells, and (2) a secondary reactive role, encompassing dermatitis-e. Read More

Eur Rev Med Pharmacol Sci 2021 Jun;25(12):4283-4288

Department of Functional Sciences, Physiology, Centre of Immuno-Physiology and Biotechnologies (CIFBIOTEH), "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Objective: The use of current surgical techniques in the management of skin cancers that are not amenable to other treatment options has become the cornerstone of dermatological surgical intervention. Among the many benign lesions and malignant lesions, such as squamous cell carcinomas, melanomas, and Merkel cell carcinomas, the tumors that are commonly excised surgically are the basal cell carcinomas (BCC). Although the majority of BCC lesions spread locally and are rarely metastatic, these lesions may recur, especially, if the excised tissue consists of positive surgical margins. Read More

Indian J Dermatol 2021 Mar-Apr;66(2):226

Department of Dermatology, Venereology and Leprosy, Government Medical College, Nagpur, Maharashtra, India.

Am J Dermatopathol 2021 Nov;43(11):788-793

UCSF Dermatopathology and Oral Pathology Service, University of California San Francisco, San Francisco, CA.

Abstract: Pseudocarcinomatous desmoplastic trichoepithelioma (PDTE) features verrucous squamous epidermal hyperplasia with a jagged undersurface overlying cords of follicular germinative cells in a fibrotic stroma. To date, only 5 cases have been reported. We identified 7 new PDTEs from 2 institutions and reviewed their clinical manifestations and immunohistochemical profile. Read More

Clin Exp Dermatol 2021 Aug 1;46(6):1052-1057. Epub 2021 May 1.

Institute for Prevention and Occupational Medicine of the German Social Accident Insurances, Ruhr-University Bochum (IPA), Bochum, Germany.

Background: Microcystic adnexal carcinoma (MAC) is a rare skin neoplasm that has not been characterized on a molecular basis.

Aim: To assess expression profiles of Hedgehog (HH) signalling molecules in MAC and control tumours.

Methods: Immunohistochemistry was performed for Sonic Hedgehog (SHH), Indian Hedgehog (IHH), Patched 1 (PTCH1) and Smoothened (SMO) on patient MAC tissue (n = 26) and control tumour tissue, including syringoma (SyG; n = 11), trichoepithelioma (TE; n = 11) and basal cell carcinoma (BCC; n = 12) tissues. Read More

J Cutan Pathol 2021 Jul 9;48(7):884-895. Epub 2021 Mar 9.

Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey.

Background: Xeroderma pigmentosum (XP) is a rare genodermatosis with a lifelong propensity to develop malignant skin tumors.

Methods: In this retrospective study, 24 XP patients were evaluated with regard to frequency and clinicopathological features of benign and malignant skin tumors.

Results: Seventeen patients had at least one malignant skin tumor diagnosed: basal cell carcinoma (BCC) in 13 patients (n = 72), basosquamous carcinoma in three patients (n = 4), squamous cell carcinoma in six patients (n = 13), keratoacanthoma in three patients (n = 15), and melanoma in six patients (n = 18). Read More

JAAD Case Rep 2021 Feb 5;8:80-82. Epub 2021 Jan 5.

DiSSal Section of Dermatology, San Martino Polyclinic Hospital IRCCS, University of Genoa, Genoa, Italy.

Australas J Dermatol 2021 May 5;62(2):e192-e200. Epub 2021 Jan 5.

Department of Dermatology, Mater Misericordiae Health Services, Brisbane, Queensland, Australia.

Trichoepithelioma is a rare benign adnexal neoplasm that can occur in various forms including solitary, multiple, familial or nonfamilial. Multiple facial trichoepithelioma can be associated with significant psychosocial burden. Conventional treatment modalities such as surgical excision and ablative laser have variable results and can be associated with unacceptable complications and tumour regrowth. Read More

Histopathology 2021 Jun 6;78(7):970-975. Epub 2021 Apr 6.

Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.

Aims: Trichoblastic carcinomas (malignant trichoblastomas) are rare and poorly documented neoplasms characterised by malignant transformation of a pre-existing benign trichoblastoma, and are subdivided histologically into low-grade and high-grade tumours. Whereas morphologically low-grade trichoblastic carcinomas show indolent behaviour, morphologically high-grade trichoblastic carcinomas have been associated with a poor prognosis, but little is known about their true biological potential. The aim of this study was to better define the clinicopathological features and outcomes of morphologically high-grade trichoblastic carcinomas. Read More

Am J Dermatopathol 2021 Sep;43(9):637-641

Departments of Pathology.

Abstract: Basal cell carcinoma (BCC) is the most common skin cancer, and it has numerous histologic mimics with variable prognoses and treatments. Although some immunohistochemical stains can be used for the differential diagnosis of BCC, variability and overlap in results can complicate their interpretation. Immunohistochemical staining for glioma-associated oncogene-1 (Gli-1) was performed on 26 nodular BCCs, 22 infiltrative BCCs, 9 basaloid squamous cell carcinomas, 12 desmoplastic trichoepitheliomas, 19 Merkel cell carcinomas, 11 sebaceous carcinomas, 10 cylindromas, 14 spiradenomas, 12 adenoid cystic carcinomas (AdCC), and 1 solitary trichoepithelioma. Read More

Clin Exp Dermatol 2021 Jun 28;46(4):792-794. Epub 2020 Dec 28.

Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Cureus 2020 Oct 16;12(10):e10982. Epub 2020 Oct 16.

Neurosurgery, University of Chicago Pritzker School of Medicine, Chicago, USA.

Brooke-Spiegler syndrome (BSS) is a rare hereditary autosomal dominant disorder with variable phenotypic expressivity that results in a variety of benign cutaneous face, scalp, and neck tumors with a histology profile of cylindroma, spiradenoma and trichoepithelioma. Reports of lymph node and distant metastasis are scarce. We present the first case of Brooke-Spiegler syndrome with metastasis to the cervical spine. Read More

Ophthalmic Plast Reconstr Surg 2021 Jul-Aug 01;37(4):e154

From the Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology and Visual Sciences, Federal University of S. Paulo, S. Paulo, SP, Brazil.

J Clin Aesthet Dermatol 2020 Jul 1;13(7):41-44. Epub 2020 Jul 1.

All authors are with the Department of Dermatology, University of California, Irvine, in Irvine, California.

Patients with Brooke-Spiegler Syndrome (BSS) can present with benign cylindromas, spiradenomas, spiradenocylindromas, and trichoepithelioma. Therapy options include excision, electrocautery, CO laser ablation, dermabrasion, and radiofrequency. Here, we present a patient with BSS with multiple trichoepitheliomas who was successfully treated with erbium:yttrium-aluminum-garnet (YAG) laser therapy and review similar cases of BSS treated with a YAG laser modality. Read More

Case Rep Dent 2020 7;2020:5648647. Epub 2020 Sep 7.

Department of Oral Pathology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

Trichoepitheliomas (TE) are benign skin tumours of the pilosebaceous apocrine unit with follicular differentiation. Multiple familial trichoepithelioma (MFT) is a considerably rare condition inherited in an autosomal dominant pattern. We present a case of a 15-year-old male who presented with multiple papulo-nodular lesions in the central face and a family history of a similar type of lesions from his mother. Read More

Cureus 2020 Aug 12;12(8):e9703. Epub 2020 Aug 12.

Pathology, South Bend Medical Foundation, South Bend, USA.

Desmoplastic trichoepitheliomas (DTEs) are benign cutaneous neoplasms that originate from the hair follicle and exhibit a preference for the facial region. This type of neoplasm is characterized by accelerated growth, with vigorous histologic and immunohistochemical features that may be confused with other skin cancers. Thus, the objective of this study is to establish a definitive diagnosis that can be widely used. Read More

Am J Dermatopathol 2021 Mar;43(3):191-197

Department of Dermatology, University of Puerto Rico School of Medicine, San Juan, PR; and.

Abstract: Basal cell carcinoma (BCC) is the most common malignancy of the skin. It is an epithelial neoplasm with origin in the precursor cells of the interfollicular epidermis. Even though it has low metastatic potential, delay in management may lead to local destruction and morbidity. Read More

Mol Genet Genomic Med 2020 10 11;8(10):e1441. Epub 2020 Aug 11.

Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Background: CYLD cutaneous syndrome (CCS; syn. Brooke-Spiegler syndrome) is a rare autosomal dominant hereditary disease characterized by multiple adnexal skin tumors including cylindromas, spiradenomas, and trichoepitheliomas. More than 100 germline mutations of the cylindromatosis (CYLD) gene have been reported in CCS and most of them are frameshift mutations or small alterations. Read More

J Am Osteopath Assoc 2020 Aug 6. Epub 2020 Aug 6.

Skin Res Technol 2021 Mar 23;27(2):283-284. Epub 2020 Jul 23.

Department of Dermatology, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhenzhou University, Zhengzhou, China.

Int J Dermatol 2021 Mar 20;60(3):e83-e84. Epub 2020 Jul 20.

Department of Dermatology, Mayo Clinic, Scottsdale, AZ, USA.

Arch Craniofac Surg 2020 Jun 29;21(3):202-205. Epub 2020 Jun 29.

Department of Plastic and Reconstructive Surgery, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Korea.

Trichoepithelioma is a benign hair follicle tumor that can undergo malignant transformation into basal cell carcinoma in rare cases. Due to the similar clinical and histological features of trichoepithelioma and basal cell carcinoma, distinguishing between these types of tumors can be a diagnostic challenge. Punch biopsy obtains only a small sample of the entire lesion, and thus inherently involves a risk of misdiagnosis between histologically similar diseases. Read More