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Int J Parasitol Parasites Wildl 2021 Aug 24;15:195-198. Epub 2021 May 24.

Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161, Rome, Italy.

Within the genus is the only recognized non-encapsulated species known to infect mammals and birds. In October 2020, larvae recovered from muscle tissues of a wolf () originating from Molise Region, Central Italy, were molecularly confirmed as those of and . This is the first detection of from a wolf. Read More

Vet Res 2021 Jun 11;52(1):85. Epub 2021 Jun 11.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.

Trichinellosis, which is caused by nematodes of the genus Trichinella, is one of the most important zoonotic parasite diseases in the world. A rapid and sensitive immunochromatographic strip (ICS) based on Eu (III) nanoparticles (EuNPs) was developed for the detection of Trichinella spiralis (T. spiralis) infection in pigs. Read More

Front Immunol 2021 21;12:639260. Epub 2021 May 21.

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

The parasitic nematode causes trichinellosis, a serious food-borne parasitic zoonosis worldwide. Infection with may also cause myocarditis. In the present study, we used mouse models to assess the impact of blockage of galectin-receptor interactions by α-lactose on cardiac immunopathology during acute experimental infection. Read More

Diagnostics (Basel) 2021 May 25;11(6). Epub 2021 May 25.

Victor Babes University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq. No. 2, 300041 Timisoara, Romania.

We reviewed the evidence on features of central nervous system (CNS) involvement in trichinellosis, systematically searching five databases (to January 2021). We categorized clinical features based on their diagnostic value as warning signs for severe CNS infection (with outcome death) or non-specific signs (outcome improvement). They were suggestive of severe infection if they substantially raised death probability. Read More

Parasit Vectors 2021 May 26;14(1):282. Epub 2021 May 26.

Programa de Salud Ambiental, Escuela de Salud Pública and Departamento de Medicina, Facultad de Medicina, Universidad de Chile, Independencia 939, 8380453, Santiago, Chile.

Trichinellosis is a foodborne disease caused by several Trichinella species around the world. In Chile, the domestic cycle was fairly well-studied in previous decades, but has been neglected in recent years. The aims of this study were to analyze, geographically, the incidence of trichinellosis in Chile to assess the relative risk and to analyze the incidence rate fluctuation in the last decades. Read More

Rev Bras Parasitol Vet 2021 24;30(3):e002821. Epub 2021 May 24.

Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, Ñuble, Chile.

Trichinellosis is a zoonosis caused by nematodes of the Trichinella genus, of which 10 species have been described. Species identification when larvae is found is only possible using molecular tools. Meat from pigs and game animals not subjected to veterinary inspection are the main sources of human infections. Read More

Trop Anim Health Prod 2021 May 24;53(3):338. Epub 2021 May 24.

State Veterinary Institute Prague, Sídlištní 136/24, 165 03, Prague 6, Czech Republic.

The protozoan parasites Theileria equi and Babesia caballi, transmitted by ticks, cause equine piroplasmosis, the most prevalent tick-borne disease in equids. Trichinellosis is a worldwide food-borne zoonosis caused by helminth Trichinella spp. that can lead to serious disease in humans, with fatal outcome. Read More

J Helminthol 2021 May 25;95:e26. Epub 2021 May 25.

Department of Medical parasitology, Faculty of medicine, Zagazig University, Zagazig44159, Egypt.

Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with those of albendazole and prednisolone, which are conventionally used to treat trichinellosis. Read More

Abdom Radiol (NY) 2021 May 24. Epub 2021 May 24.

Department of Infectious Diseases, Istituto Superiore di Sanità, Rome, Italy.

IDCases 2021 17;24:e01124. Epub 2021 Apr 17.

Department of Infectious Diseases, Hospital de São Bernardo, Centro Hospitalar de Setúbal, R. Camilo Castelo Branco 175, 2910-548, Setúbal, Portugal.

Trichinellosis is an emerging or re-emerging foodborne parasitic zoonotic disease caused by nematodes of the genus . It represents a global food safety problem and a public health hazard. This case report aims to describe the first case of human trichinellosis in Portugal since the creation of the European Union surveillance system. Read More

Acta Trop 2021 Aug 7;220:105947. Epub 2021 May 7.

College of Veterinary Medicine, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, China; Key Laboratory of animal production and product quality safety of Ministry of Education, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin Province 130118, China. Electronic address:

Trichinellosis is a significant food-borne zoonotic parasitic disease caused by parasite Trichinella. Given the side effects of anti-Trichinella drugs (e.g. Read More

PLoS Negl Trop Dis 2021 May 10;15(5):e0009408. Epub 2021 May 10.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Trichinellosis is a major foodborne parasitosis caused by Trichinella spiralis. In the present study, a serine protease gene from an adult T. spiralis (Ts-Adsp) cDNA library was cloned, expressed in Escherichia coli and purified by Ni-affinity chromatography. Read More

Zoonoses Public Health 2021 May 7. Epub 2021 May 7.

Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, Chile.

Trichinellosis is a zoonosis with worldwide distribution. Several hosts have been recognized around the world; however, there is a lack of knowledge of the role of feral mammals in Chile in its transmission. Herein, we tested muscle samples from 555 individuals among American minks (Neovison vison Schreber, 1777. Read More

Int J Mol Sci 2021 Apr 30;22(9). Epub 2021 Apr 30.

Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., PL-02-093 Warszawa, Poland.

Novel evidence is presented allowing further clarification of the mechanism of the slow-binding thymidylate synthase (TS) inhibition by N-hydroxy-dCMP (N-OH-dCMP). Spectrophotometric monitoring documented time- and temperature-, and N-OH-dCMP-dependent TS-catalyzed dihydrofolate production, accompanying the mouse enzyme incubation with N-OH-dCMP and N-methylenetetrahydrofolate, known to inactivate the enzyme by the covalent binding of the inhibitor, suggesting the demonstrated reaction to be uncoupled from the pyrimidine C(5) methylation. The latter was in accord with the hypothesis based on the previously presented structure of mouse TS (cf. Read More

Parasitol Res 2021 May 4. Epub 2021 May 4.

Department of Medical Parasitology, Faculty of Medicine, Tanta University, Tanta, Egypt.

Ivermectin (IVM) is one of the competitive treatments used for trichinellosis. However, several studies linked its efficacy with early diagnosis and administration to tackle the intestinal phase with limited activity being recorded against encysted larvae. The aim of this study was to employ niosomes for enhancing effectiveness of oral IVM against different stages of Trichinella spiralis (T. Read More

Clin Microbiol Infect 2021 Apr 24. Epub 2021 Apr 24.

Unité de Parasitologie - Mycologie, Département de Bactériologie Virologie Hygiène Mycologie Parasitologie, DHU VIC, APHP, CHU Henri Mondor, Créteil, France; EA DYNAMYC UPEC, ENVA, Faculté de Médecine de Créteil, Créteil, France. Electronic address:

Vet Parasitol 2020 Nov 10:109308. Epub 2020 Nov 10.

The Graduate School, University of Santo Tomas, España Boulevard, Sampaloc, Metro Manila, Philippines; Research Center for Natural and Applied Sciences, University of Santo Tomas, España Boulevard, Sampaloc, Metro Manila, Philippines; College of Science, University of Santo Tomas, España Boulevard, Sampaloc, Metro Manila, Philippines.

Trichinella spp. is considered as one of the most widespread food-borne zoonotic parasites globally. The disease it causes impacts human public health, pig production, and food safety. Read More

Int J Nanomedicine 2021 29;16:2477-2486. Epub 2021 Mar 29.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, People's Republic of China.

Purpose: Sensitive and selective point-of-care biosensor is an urgent pursuit of serological antibody detection to control parasite pathogen. For specific, quantitative and on-site screening of infection in livestock, a quantum dot nanobead-monoclonal antibody (QB-mAb) probe-based immunochromatographic assay (ICA) was developed by introducing a competitive sandwich strategy (QB-CICA).

Methods: In the QB-CICA, QB-mAb probes competed with serum antibody for a particular epitope, followed by immunocomplexes binding to capture antibody on the test line. Read More

Iran J Parasitol 2021 Jan-Mar;16(1):122-135

National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Center for Tropical Diseases, Key Laboratory of Parasite and Vector Biology, National Health and Family Planning Commission, Shanghai 200025, China.

Background: Trichinellosis is a serious food-borne parasitic zoonosis, thus finding high quality antigens is the key to serodiagnosis of trichinosis. This article reports the characterization and sensitivity of four recombinant proteins expressed by four genes (, , , and ) from different developmental stages of for the diagnosis of trichinellosis in mice.

Methods: This study was conducted in Jilin University and National Institute of Parasitic Diseases of Chinese Center for Disease Control and Prevention in 2017-2018. Read More

Am J Trop Med Hyg 2021 Mar 29. Epub 2021 Mar 29.

3Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia.

Human trichinellosis can be diagnosed by a combination of medical history, clinical presentation, and laboratory findings, and through detection of anti-Trichinella IgG in the patient's sera. ELISA using excretory-secretory (E/S) antigens of Trichinella spiralis larvae is currently the most used assay to detect Trichinella spp. antibodies. Read More

Parasitol Res 2021 Mar 26. Epub 2021 Mar 26.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, 130062, China.

Taenia and Trichinella parasites are globally distributed foodborne zoonotic pathogens transmitted from animal to humans via consumption of raw or undercooked meats. This short review is intended to provide the parasites community a snapshot of the literature on the current and recent prevalence of taeniasis and trichinellosis in humans and animals in the Far East countries. Prevalence rates in these countries are highly diverse due to differences in development, culture, ethnic and religious background, animal forming practices, and eating habits. Read More

Exp Parasitol 2021 May 11;224:108099. Epub 2021 Mar 11.

Centre for Infectious Disease Control - Zoonoses and Environmental Microbiology, National Institute for Public Health and the Environment, Bilthoven, 3720, BA, the Netherlands. Electronic address:

Background: Trichinellosis is caused by consumption of raw or undercooked meat containing infective Trichinella muscle larvae (ML). Only few studies on heat-inactivation of Trichinella ML are available in literature and more validated data concerning heat inactivation is needed to improve the risk estimation.

Objective And Methods: The aim of the present study was to evaluate the two in vitro methods "staining" and "morphological examination" as proxies for Trichinella ML heat inactivation in comparison with the mouse bioassay method to get more insight in the relationship between heat, heating time and inactivation of Trichinella ML. Read More

J Parasitol 2021 03;107(2):141-146

Department of Immunity and Biochemistry, Institute of Parasitic Disease, Hangzhou Medical College, Hangzhou, 310053, China.

Early diagnosis of trichinellosis is still difficult because of the lack of specific symptoms and limited window for serological detection. Here we established an assay based on tracing phosphate ions generated during loop-mediated isothermal amplification (LAMP) to detect Trichinella spiralis DNA in rat feces during its early stage of infection. By targeting a 1. Read More

Indian J Med Microbiol 2021 Apr 27;39(2):235-239. Epub 2021 Feb 27.

Department of Medical Parasitology, PGIMER, Chandigarh, India. Electronic address:

Trichinellosis is a zoonotic parasitic infection caused by nematodes of the genus Trichinella. Humans mostly get infected by eating raw/under-cooked pork. In India, it has been reported mostly as sporadic cases especially from North Eastern and Eastern part of country. Read More

Parasit Vectors 2021 Mar 1;14(1):130. Epub 2021 Mar 1.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, 130062, China.

Background: Parasites of the genus Trichinella are the pathogenic agents of trichinellosis, which is a widespread and severe foodborne parasitic disease. Trichinella spiralis resides primarily in mammalian skeletal muscle cells. After invading the cells of the host organism, T. Read More

BMC Vet Res 2021 Feb 28;17(1):94. Epub 2021 Feb 28.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Background: Trichinellosis, caused by Trichinella spiralis, is a serious foodborne parasitic zoonosis. Tibetan pig is an infrequent, endemic plateau pig species, mainly distributed in Tibet Plateau, China. Because of the free-range system, Tibetan pigs are at risk of infection with Trichinella. Read More

PLoS Negl Trop Dis 2021 02 18;15(2):e0009040. Epub 2021 Feb 18.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun, China.

Trichinella spiralis (T. spiralis) is a widely distributed pathogenic microorganism that causes trichinellosis, a disease that has the potential of causing severe harm to their host. Numerous studies have demonstrated that autophagy can be triggered by microbial infection, such as bacteria, viruses, protozoa, and parasitic helminths. Read More

Infect Immun 2021 Apr 16;89(5). Epub 2021 Apr 16.

Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Trichinellosis is one of most neglected foodborne zoonoses worldwide. During infection, the intestinal immune response is the first line of defense and plays a vital role in the host's resistance. Previous studies indicate that purinergic P2X7 receptor (P2X7R) and pyrin domain-containing protein 3 (NLRP3) inflammasome are involved in the intestinal immune response in infection. Read More

Parasitology 2021 Apr 13;148(5):630-635. Epub 2021 Jan 13.

Medical Research Institute, University of Alexandria, Department, Alexandria, Egypt.

The present work aimed at studying the efficacy of mebendazole (MBZ) compared to artemisinin (ART) for the treatment of trichinellosis at various phases of infection. Seventy Swiss albino mice were orally infected by 300 Trichinella spiralis (T. spiralis) larvae. Read More

Commun Biol 2021 Jan 29;4(1):134. Epub 2021 Jan 29.

Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, China.

Genome assemblies provide a powerful basis of comparative multi-omics analyses that offer insight into parasite pathogenicity, host-parasite interactions, and invasion biology. As a unique intracellular nematode, Trichinella consists of two clades, encapsulated and non-encapsulated. Genomic correlation of the distinct differences between the two clades is still unclear. Read More