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Parasit Vectors 2018 Dec 12;11(1):631. Epub 2018 Dec 12.

European Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, viale Regina Elena 299, 00161, Rome, Italy.

Background: Trichinellosis is a meat-borne zoonotic disease caused by parasites of the genus Trichinella. To date, 12 taxa have been described. The identification of Trichinella species is crucial in order to identify the possible source of infection, the geographical origin of the parasite and to assess risk of infection for domestic pigs and humans. Read More

Vet Res 2018 Dec 5;49(1):119. Epub 2018 Dec 5.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

Trichinellosis is one of the most serious foodborne parasitic zoonosis with worldwide distribution, and it is necessary to develop a vaccine to interrupt transmission from animals to humans. Trichinella spiralis adult-specific DNase II-1 (TsDNase II) were identified by immunoproteomics in surface or excretory/secretory proteins of adult worms (AW) and intestinal infective larvae (IIL). The aim of this study was to investigate the systemic, mucosal responses and immune protection elicited by oral vaccination with TsDNase II DNA vaccine delivered by attenuated Salmonella typhimurium strain⊿cyaSL1344. Read More

Foodborne Pathog Dis 2018 Nov 27. Epub 2018 Nov 27.

Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine, University of Helsinki , Helsinki, Finland .

Wild boar populations around the world have increased dramatically over past decades. Climate change, generating milder winters with less snow, may affect their spread into northern regions. Wild boars can serve as reservoirs for a number of bacteria, viruses, and parasites, which are transmissible to humans and domestic animals through direct interaction with wild boars, through contaminated food or indirectly through contaminated environment. Read More

Front Microbiol 2018 5;9:2504. Epub 2018 Nov 5.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, China.

Deoxyribonuclease II (DNase II) is a widespread endonuclease, which can degrade the DNA. adult-specific DNase II-1 (TsDNase II-1) and DNase II-7 (TsDNase II-7) were identified in excretory-secretory (ES) or surface proteins of adult worm (AW) and intestinal infective larvae (IIL) using immunoproteomics with early infection sera. The aim of this study was to characterize the two DNase II enzymes and to investigate their role as potential vaccine candidate target molecules. Read More

Parasit Vectors 2018 Nov 12;11(1):584. Epub 2018 Nov 12.

Witold Stefański Institute of Parasitology, Polish Academy of Sciences, Twarda 51/55, 00-818, Warsaw, Poland.

Background: Trichinella britovi is the second most common species of Trichinella that may affect human health. As an early diagnosis of trichinellosis is crucial for effective treatment, it is important to identify sensitive, specific and common antigens of adult T. britovi worms and muscle larvae. Read More

Vet Parasitol 2018 Oct 9;262:1-5. Epub 2018 Sep 9.

European Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy. Electronic address:

Carnivore and omnivore animals are the main reservoir hosts of nematodes of the genus Trichinella. Out of the twelve taxa identified so far in the world, four, namely Trichinella spiralis, Trichinella nativa, Trichinella britovi and Trichinella pseudospiralis, are circulating in Europe. All these four species were detected in Finnish wild animals and T. Read More

Mem Inst Oswaldo Cruz 2018 Oct 29;113(11):e180305. Epub 2018 Oct 29.

US Food and Drug Administration Center for Food Safety and Applied Nutrition, Office of Applied Nutrition and Safety Assessment, Laurel, MD, USA.

BACKGROUND Human trichinellosis is a foodborne parasitic zoonotic disease caused by ingestion of raw or undercooked meat infected with nematode larvae of the genus Trichinella. In the USA, sporadic cases and outbreaks caused by the consumption of wild game meat infected with Trichinella have been reported. The current methods for diagnosis such as serology and microscopy are not specific, may result in false negative results, and cannot differentiate encapsulated Trichinella larvae to species level. Read More

Biomed Pharmacother 2018 Dec 27;108:934-940. Epub 2018 Sep 27.

Department of Parasitology, Basic Medical College, Dalian Medical University, Dalian, 116044, Liaoning, China. Electronic address:

Although trichinosis is one of the global food-borne parasitic diseases and is considered an emerging/re-emerging disease that has been reported in 66 countries, the drugs for its prevention and treatment have not been thoroughly investigated. Wortmannilactone F (WF) has been reported as a blocker of the helminth mitochondria respiratory chain by inhibiting NADH-fumarate reductase in the mitochondrial inner membrane. CXCL8 (3-73) K11R/G31 P(G31 P) has been reported as a CXCL8 analogue that has the affinity to CXCR1 and CXCR2. Read More

N Engl J Med 2018 Oct;379(14):1364-1369

From the Departments of Emergency Medicine (A.S., B.F., B.P.) and Laboratory Medicine and Pathology (V.N.), Alameda Health System-Highland Hospital, Oakland, and the Department of Emergency Medicine and Division of Infectious Diseases, Olive View-UCLA Medical Center, Sylmar (D.A.T.) - both in California.

Vet Immunol Immunopathol 2018 Sep 29;203:13-20. Epub 2018 Jul 29.

Department of Food Hygiene of Animal Origin, Faculty of Veterinary Medicine, University of Life Sciences in Lublin, Akademicka 12, 20-950 Lublin, Poland.

The aim of the present study was to evaluate the detection of trichinellosis using ELISA, and to determine the degree of variation of IgG antibodies against excretory-secretory (E-S) antigens of T. spiralis muscle larvae. Ten young Polish Large White native breed pigs were experimentally inoculated with a low dose of 300 invasive Trichinella spiralis (T. Read More

Vet Res 2018 Sep 6;49(1):87. Epub 2018 Sep 6.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

Trichinellosis is a worldwide important food-borne zoonosis caused mainly by ingesting raw or undercooked pork infected with Trichinella spiralis larvae. The development of vaccine is needed for preventing swine from Trichinella infection to ensure pork safety. Previous studies showed that T. Read More

Res Vet Sci 2018 Oct 23;120:4-10. Epub 2018 Aug 23.

College of Animal Science and Technology and Jilin Provincial Engineering Research Center of Animal probiotics, Jilin Agricultural University, 2888 Xincheng Street, Changchun, Jilin 130118, China. Electronic address:

Trichinella spiralis is an intestinal nematode parasite that can cause trichinellosis in humans and animals worldwide. The most important known hosts of T. spiralis are pigs, horses, dogs and cats. Read More

Trop Anim Health Prod 2018 Aug 13. Epub 2018 Aug 13.

Department of Biomedical Sciences, School of Veterinary Medicine, Faculty of Agriculture and Natural Resources, University of Namibia, P. Bag 13301, Pioneerspark, Windhoek, Namibia.

Trichinellosis is a worldwide zoonosis with genotypes affecting different domestic and wild animals and is widely distributed throughout the world. Species and genotypes of this genus affecting different animals have been identified. Despite its occurrence in Sub-Saharan countries, the presence of trichinellosis in Botswana is yet to be confirmed. Read More

Vet Res 2018 08 2;49(1):79. Epub 2018 Aug 2.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

The aim of this study was to study the molecular characteristics of Trichinella spiralis galectin (Tsgal) and interactions between Tsgal and host's intestinal epithelial cells (IECs). The functional domain of Tsgal was cloned and expressed in an E. coli system. Read More

Emerg Infect Dis 2018 Aug;24(8):1532-1535

An outbreak of trichinellosis occurred in Japan in December 2016. All case-patients had eaten undercooked bear meat, from which Trichinella larvae were subsequently isolated. DNA sequencing analysis of the mitochondrial genes cytochrome c-oxidase subunit 1 and internal transcribed spacer 2 confirmed that Trichinella T9 had caused the outbreak. Read More

Int J Med Sci 2018 22;15(8):802-807. Epub 2018 May 22.

Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Republic of Korea.

establishes a chronic infection in skeletal muscle by developing nurse cells within muscle fibers. During symbiosis in host, changes in the muscle fibers and inflammation may affect muscle function. : We investigated muscle strength and inflammation in infected mice during 1 to 48 weeks after infection. Read More

Vet Res 2018 07 13;49(1):59. Epub 2018 Jul 13.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

In our previous work, a Trichinella spiralis putative serine protease (TsSP) was identified from ES products of T. spiralis intestinal infective larvae (IIL) and adult worms (AW) by immunoproteomics: it was highly expressed in IIL compared with muscle larvae (ML). In this study, the TsSP biological characteristics in larval invasion and growth were identified and its potential as a vaccine target against Trichinella infection were investigated. Read More

J Parasitol 2018 Oct 16;104(5):557-559. Epub 2018 Jul 16.

2   University of Belgrade, Faculty of Veterinary Medicine, Department of Food Hygiene and Technology, Bulevar oslobodjenja 18, 11000 Belgrade, Serbia.

After a human trichinellosis outbreak in Zlatibor District, Serbia, in 2016, Trichinella larvae were found in wild boar ( Sus scrofa) meat products. One hundred and fourteen people were infected during the outbreak. The larvae were determined to be Trichinella britovi using the polymerase chain reaction method. Read More

Parasit Vectors 2018 Jun 19;11(1):353. Epub 2018 Jun 19.

European Union Reference Laboratory for Parasites, Istituto Superiore di Sanità, Rome, Italy.

Background: The zoonotic nematode Trichinella britovi was discovered in two neighboring Mediterranean islands of Corsica and Sardinia, almost simultaneously at the beginning of the 21st century. An epidemiological link between the two parasite populations was generally assumed. In 2015, an outbreak of trichinellosis in Nice, the South of France, was reportedly caused by the consumption of raw pork delicatessen imported from Corsica. Read More

Int J Infect Dis 2018 Aug 13;73:69-71. Epub 2018 Jun 13.

Institute of Biological Sciences, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia.

Objectives: The serological diagnosis of human infection with Angiostrongylus cantonensis remains problematic because there are no commercially available validated tests. Most laboratories use domestically prepared tests such as the enzyme-linked immunosorbent assay (ELISA) or immunoblotting. Since laboratory facilities are not always available in endemic areas, we developed and assessed a rapid lateral flow immunochromatographic assay (AcQuick Test) to detect anti-A. Read More

Folia Parasitol (Praha) 2018 May 29;65. Epub 2018 May 29.

Department of Parasitology, Medical College, Zhengzhou University, PR China.

Cysteine protease is a superfamily of widespread proteolytic enzymes and plays a major role in larval invasion, migration, exsheathing, survival and immune evasion in parasites. In the present study, the gene coding cysteine proteinase of the nematode Trichinella spiralis (Owen, 1835) was cloned into pQE-80L and subsequently expressed in E. coli JM109. Read More

Transbound Emerg Dis 2018 Dec 6;65(6):1447-1458. Epub 2018 Jun 6.

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.

Trichinella spiralis, the causative agent of trichinellosis, is able to infect a wide range of carnivores and omnivores including human beings. In the past 30 years, a mass of vaccination efforts has been performed to control T. spiralis infection with the purpose of reduction in worm fecundity or decrease in muscle larval and adult burdens. Read More

PLoS One 2018 5;13(6):e0198205. Epub 2018 Jun 5.

Department of Microbiology and Parasitology, Anhui Key Laboratory of Infection and Immunity, Bengbu Medical College, Bengbu, China.

Trichinella spiralis mainly dwells in the muscle tissue of its host and is the main causative agent of trichinellosis in humans. Nitric oxide (NO), an important intracellular signaling molecule that may restrict pathogen growth in infected hosts, has been known for its anti-pathogenic activity, including resistance to T. spiralis. Read More

PLoS Negl Trop Dis 2018 05 18;12(5):e0006502. Epub 2018 May 18.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.

Background: Trichinellosis is a serious food-borne parasitic zoonosis worldwide. In the effort to develop vaccine against Trichinella infection, we have identified Trichinella spiralis Heat shock protein 70 (Ts-Hsp70) elicits partial protective immunity against T. spiralis infection via activating dendritic cells (DCs) in our previous study. Read More

PLoS Negl Trop Dis 2018 05 14;12(5):e0006485. Epub 2018 May 14.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, P. R. China.

Background: Trichinellosis is a serious zoonositc parasitosis worldwide. Because its clinical manifestations aren't specific, the diagnosis of trichinellosis is not easy to be made. Trichinella spiralis muscle larva (ML) excretory-secretory (ES) antigens are the most widely applied diagnostic antigens for human trichinellosis, but the major drawback of the ES antigens for assaying anti-Trichinella antibodies is the false negative in the early Trichinella infection period. Read More

Parasite 2018 10;25:28. Epub 2018 May 10.

Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Nematodes of the genus Trichinella are zoonotic parasites causing trichinellosis. In Iran, these parasites occur in several animal species and rare cases have been recorded in humans. To monitor the epidemiological pattern of these parasites in the Khorasan-e-Razavi province, Northeastern Iran, muscle tissues were collected from the tongues of roadkill animals between 2016 and 2017: 295 stray dogs, one red fox (Vulpes vulpes), 12 golden jackals (Canis aureus), and one wild boar (Sus scrofa). Read More

Immunol Invest 2018 Aug 3;47(6):605-614. Epub 2018 May 3.

a Department of Medical Zoology , Kyung Hee University School of Medicine , Seoul , Korea.

Trichinella spiralis infection induces Trichinella-specific IgG antibody and high level of blood eosinophil. However, the kinetics induced by different parasite burdens during infectious periods remains unclear. In this study, rats were infected with 100, 1000, or 3000 larvae of T. Read More

J Helminthol 2018 May 3:1-3. Epub 2018 May 3.

Martsinovsky Institute of Medical Parasitology,Tropical and Vector Borne Diseases,Sechenov University,Moscow,Russia.

Although there have been occasional reports of rare and low-level trichinellae infestation in beavers, no human cases of beaver-associated trichinellosis have been described. This report presents a possible case of human trichinellosis linked to beaver meat. Increasing consumption of beaver meat necessitates raising awareness of this potential source of trichinellosis. Read More

Vet Parasitol 2018 Apr 14;254:114-119. Epub 2018 Mar 14.

Witold Stefański Institute of Parasitology, Polish Academy of Sciences, 00-818 Warsaw, Twarda 51/55, Poland.

The raccoon (Procyon lotor) is a North American carnivore introduced to Europe in the 20th Century. Raccoons are believed to be the potential hosts of many parasites, or to be involved in their transmission to other animals. Nematodes of the genus Trichinella can infect many carnivorous and omnivorous animals worldwide. Read More

Parasite 2018 10;25:18. Epub 2018 Apr 10.

CIBAV research group, Veterinary Medicine School, Faculty of Agrarian Sciences, University of Antioquia, Carrera 75 No 65-87, Medellín, Colombia.

A preliminary survey of Trichinella spp. infection was conducted in Colombian swine herds between 2014 and 2016. A total of 1,773 pigs reared on farms under controlled housing conditions and processed in 34 slaughterhouses were tested either by the artificial digestion of pooled muscle samples (n = 1,173) or by serology (n = 600). Read More

Vet Parasitol 2018 Apr 21;253:94-97. Epub 2018 Feb 21.

Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada.

Trichinella is an important zoonotic parasite found in a range of wildlife species harvested for food and fur in Canada. We compared larval intensity from tongue and diaphragm, the best predilection sites in other animal species, from naturally infected, wild wolverines (Gulo gulo) (n = 95). Muscle larvae of Trichinella spp. Read More

Exp Parasitol 2018 May 27;188:58-64. Epub 2018 Mar 27.

Department of Internal Medicine and Clinic of Horses, Dogs and Cats, Division of Parasitology, Faculty of Veterinary Medicine, Wroclaw University of Environmental and Life Sciences, Norwida 31, 50-375 Wroclaw, Poland.

The influence of iridoid-anthocyanin aqueous extract of cornelian cherry fruits (CM) on hematological parameters, lymphocyte subsets and proliferation during Trichinella spiralis infection in mice was investigated. CM (100 mg/kg) was administered orally to T. spiralis-infected mice six times within a period encompassing three days prior to the infection and three days after the infection (dai). Read More

Exp Parasitol 2018 Apr 26;187:59-66. Epub 2018 Feb 26.

Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, PR China. Electronic address:

The aim of this study was to identify the biological characteristics and functions of a putative Trichinella spiralis glutathione S-transferase (TspGST). The results of real-time PCR and immunofluorescent test (IFT) showed that the TspGST gene was expressed at all of T. spiralis different developmental stages (muscle larvae, intestinal infective larvae, adult worms and newborn larvae). Read More

MMWR Morb Mortal Wkly Rep 2018 Mar 2;67(8):247-249. Epub 2018 Mar 2.

On January 15, 2017, a hospital physician notified the Alameda County Public Health Department (ACPHD) in California of a patient with a suspected diagnosis of trichinellosis, a roundworm disease transmitted by the consumption of raw or undercooked meat containing Trichinella spp. larvae (1). A family member of the initial patient reported that at least three other friends and family members had been evaluated at area hospitals for fever, myalgia, abdominal pain, diarrhea, and vomiting. Read More

Parasitol Res 2018 Mar 7;117(3):943-945. Epub 2018 Feb 7.

Department of Pathology and Parasitology, State Veterinary Institute Prague, Sídlištní 136/24, 165 00, Prague 6 - Lysolaje, Czech Republic.

Muscular sarcosporidial infections by Sarcocystis lutrae (Apicomplexa: Sarcocystidae) from the otter (Lutra lutra) and badger (Meles meles) (Carnivora: Mustelidae) were found in the Czech Republic. As part of a diversity evaluation of Sarcocystis in wild carnivores during 2016-2017, samples of diaphragm, tongue and hind-limb muscles were collected from nine districts, examined by compression and characterized molecularly. Cyst walls were thin, with no visible protrusions, and histological sections of infected muscle tissue showed no host responses. Read More

Int J Environ Res Public Health 2018 02 2;15(2). Epub 2018 Feb 2.

Department of Internal Medicine, Hospital Poprad, 058 01 Poprad, Slovakia.

Trichinellosis and cystic and alveolar echinococcosis are serious parasitic diseases transmissible between animals and humans. Moreover, alveolar echinococcosis is considered one of the most dangerous of human helminthoses. Roma communities are particularly numerous in Central and Eastern Europe. Read More

J Helminthol 2018 Jan 31:1-8. Epub 2018 Jan 31.

Center of Parasitology, A.N. Severtsov's Institute of Ecology and Evolution,33 Leninsky prospekt,Moscow,119071,Russia.

Trichinellosis, a zoonotic disease caused by nematodes of the genus Trichinella, is still a public health concern in the Arctic. The aims of this study were to investigate the seroprevalence of anti-Trichinella IgG in aboriginal peoples of two settlements in the Chukotka Autonomous Okrug (Russian Federation) on the Arctic coast of the Bering Sea, and to evaluate the survival of Trichinella nativa larvae in local fermented and frozen meat products. A seroprevalence of 24. Read More

Front Immunol 2017 15;8:1844. Epub 2018 Jan 15.

Department of Clinical Immunology and Transplantology, Medical University of Gdańsk, Gdańsk, Poland.

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While the number of clinical trials testing Tregs is already substantial, it seems to be crucial to provide some standardized characteristics of Treg products in order to minimize the problem. Read More

Korean J Parasitol 2017 Dec 31;55(6):587-599. Epub 2017 Dec 31.

Laboratory of Cell Biology and Microbiology, Academic Unit of Biological Sciences, Autonomous University of Zacatecas, Zacatecas, Zacatecas, México.

The immune response against Trichinella spiralis at the intestinal level depends on the CD4+ T cells, which can both suppress or promote the inflammatory response through the synthesis of diverse cytokines. During the intestinal phase, the immune response is mixed (Th1/Th2) with the initial predominance of the Th1 response and the subsequent domination of Th2 response, which favor the development of intestinal pathology. In this context, the glucocorticoids (GC) are the pharmacotherapy for the intestinal inflammatory response in trichinellosis. Read More

Acta Trop 2018 Sep 26;185:183-192. Epub 2017 Dec 26.

Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China; Key Clinical Laboratory of Henan Province, Zhengzhou 450052, China. Electronic address:

The drug albendazole (ABZ) has a positive effect against Trichinella spiralis infection and has been used for the treatment and prevention of trichinellosis in humans and animals. However, the molecular mechanism ofthe effects of ABZ on T. spiralis remains unknown. Read More

Iran J Public Health 2017 Dec;46(12):1712-1719

Dept. of Medical Parasitology & Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Background: Trichinellosis is an important and neglected foodborne zoonotic infectious disease in worldwide. The most human outbreaks in recent years have been related to consumption of wild boar meat. This cross-sectional study determined the prevalence of spp. Read More

Int J Infect Dis 2018 Feb 15;67:43-45. Epub 2017 Dec 15.

University of Medicine and Pharmacy "Victor Babes" Timisoara, Department of Neurology, Romania; Clinical Emergency County Hospital Timisoara, Department of Neurology, Romania.

Trichinosis is a parasitic disease that, due to variable clinical syndromes, is often underrecognized. We present the case of a patient with eosinophilia, focal neurological signs and multiple bilateral brain lesions, distributed mainly in the border zones. The diagnostic workup revealed neurotrichinosis, which should be suspected even without a clear history of consumption of poorly cooked meat. Read More

Parasit Vectors 2017 Dec 16;10(1):609. Epub 2017 Dec 16.

Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Tartu, Estonia.

Background: Raccoon dogs and red foxes are well-adapted hosts for Trichinella spp. The aims of this study were to estimate Trichinella infection prevalence and biomass and to investigate which Trichinella species circulated in these indicator hosts in Estonia.

Methods: From material collected for evaluating the effectiveness of oral vaccination program for rabies eradication in wildlife, samples from 113 raccoon dogs and 87 red foxes were included in this study. Read More

Indian J Dermatol Venereol Leprol 2018 Jan-Feb;84(1):109-113

Consultant Dermatologist and Trichologist, Eugenix Skin and Hair Sciences, Gurgaon, Haryana, India.

Vaccine 2018 01 2;36(2):248-255. Epub 2017 Dec 2.

Sun Yat-sen University Zhongshan School of Medicine, Key Laboratory of Tropical Disease Control (Sun Yat-Sen University), Ministry of Education, Guangzhou 510080, China. Electronic address:

Trichinellosis is a foodborne disease that remains a public health hazard and an economic problem in food safety. Vaccines against the parasite can be an effective way to control this disease; however, commercial vaccines against Trichinella infection are not yet available. Trichinella cathepsin B proteins appear to be promising targets for vaccine development. Read More

Parasitol Res 2018 Jan 30;117(1):201-212. Epub 2017 Nov 30.

Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

The present study explored potentially immunogenic proteins of the encapsulated (Trichinella spiralis) and non-encapsulated (T. pseudospiralis, T. papuae) species within the genus Trichinella. Read More

J Helminthol 2017 Nov 23:1-9. Epub 2017 Nov 23.

Serbian National Reference Laboratory for Trichinellosis (NRLT),Institute for the Application of Nuclear Energy - INEP,University of Belgrade,Banatska 31b,11080 Belgrade,Serbia.

Infection with parasites from the Trichinella genus occurs in many vertebrates but disease only occurs in humans (trichinellosis). Humans are infected after the consumption of raw or undercooked meat from infected wild or domestic animals (usually swine or horses). Using the monoclonal antibody (mAb) 7C2C5, specific for an epitope unique to the muscle larvae of the genus Trichinella, we have developed a competitive enzyme-linked immunosorbent assay (c-ELISA) that enables the rapid detection of Trichinella-specific antibodies in sera originating from two different host species (human, swine) infected with either Trichinella spiralis or Trichinella britovi. Read More

Pol J Vet Sci 2017 Sep;20(3):445-454

.

The aim of the study carried out on ten young (10-week old) pigs of the native Polish Large White breed experimentally infected with a low dose of 300 invasive muscle larvae (ML) of Trichinella spiralis was intravital detection of trichinellosis using the E-S ELISA test, determination of a variation level of IgG antibodies against excretory-secretory (E-S) antigens of T. spiralis muscle larvae and finally, describing the intensity of T. spiralis larvae infection in selected muscles. Read More

Front Microbiol 2017 31;8:2069. Epub 2017 Oct 31.

Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis/College of Veterinary Medicine, Jilin University, Changchun, China.

The intestinal phase is critical for trichinellosis caused by (), as it determines both process and consequences of the disease. Several previous studies have reported that induces the initial predominance of a Th1 response during the intestine stage and a subsequent predominance of a Th2 response during the muscle stage. In the present study, immune cells and cytokine profile were investigated in the intestine of mice infected with . Read More

Vet Parasitol 2017 Nov 1;246:1-4. Epub 2017 Sep 1.

Istituto Superiore di Sanità, viale Regina Elena 299, 00161 Rome, Italy. Electronic address:

In Europe, Trichinella spiralis, the most dangerous species for humans of the genus Trichinella, has a patchy distribution with important foci in Eastern countries and Spain. This zoonotic pathogen was apparently not circulating among wild and domestic animals of Italy. In 2016, muscle larvae belonging to this nematode species were detected in a red fox (Vulpes vulpes) shot in the Piacenza province (Northern Italy). Read More