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Exp Parasitol 2022 Jun 22:108314. Epub 2022 Jun 22.

Clinical and Molecular Parasitology Department, National Liver Institute, Menoufia University, Shebin Elkom, Menoufia, Egypt. Electronic address:

Albendazole (ALB) is the most used therapeutic drug for trichinellosis treatment, but it has many drawbacks. Hence, the search for alternative natural compounds is a goal for researchers. The present work aimed to test the in vitro anthelmintic effect of Tomex (Allium sativum) against adult and muscular larva of Trichinella spiralis (T. Read More

Clin Exp Immunol 2022 Jun 22. Epub 2022 Jun 22.

Department of Translational Research NTMC, University of Pisa, Italy.

Glutathione S-transferase omega-1 (GSTO1-1) is a cytosolic enzyme involved in the modulation of critical inflammatory pathways as well as in cancer progression. Auto-antibodies against GSTO1-1 were detected in serum of patients with esophageal squamous cell carcinoma and were proposed as potential biomarkers in the early detection of the disease. Our data demonstrate that anti-GSTO1-1 antibodies can be found also in different types of inflammatory diseases, such as autoimmune rheumatoid arthritis and infectious SARS-CoV-2 and trichinellosis. Read More

Front Med (Lausanne) 2022 11;9:881356. Epub 2022 May 11.

National Medical Center for Major Public Health Events, Department and Institute of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Parasitic co-infection is commonly observed in natural populations, yet rare in the laboratory. Multiparasitism can have negative effects on the host, ranging from the atypical manifestations to increased mortality, consequently, it may be misdiagnosed and treated with unsuitable anthelmintic medicines. Therefore, reliable diagnosis is critical for appropriate treatment of parasitic co-infection. Read More

J Helminthol 2022 May 24;96:e35. Epub 2022 May 24.

National Reference Laboratory for Trichinellosis (NRLT), Department for Immunology and Immunoparasitology, Institute for the Application of Nuclear Energy - INEP, University of Belgrade, Banatska 31b, 11080 Belgrade, Serbia.

Trichinellosis in humans is most often caused by the parasite Trichinella spiralis. The clinical course of the disease is diverse and the symptoms can vary from mild to severe. Symptoms usually disappear within a few months, but encysted larvae in the muscles can cause myalgia and weakness that last for years. Read More

Food Waterborne Parasitol 2022 Jun 13;27:e00165. Epub 2022 May 13.

Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy.

Serological tests are widely used for the detection of spp. infections in animals and humans. Despite some limitations, (such as low sensitivity in the early period after infection) ELISA and western blot testing have demonstrated good performance when excretory/secretory products from muscle larvae are used as antigens in agreement with the International Commission on Trichinellosis. Read More

Helminthologia 2022 Mar 4;59(1):37-45. Epub 2022 May 4.

Fatima College of Health Sciences, IAT, ADU UAE.

Trichinellosis is a nematode-causing disease distinguished by its continuous transmission in the carnivores and omnivores. Despite effective eradication of the enteral forms, conventional drugs fail to eliminate the migrating and muscle ones. Over the past years, researchers intensified the work on herbal medicines as alternatives or aids to albendazole, the reference drug. Read More

Helminthologia 2022 Mar 4;59(1):18-36. Epub 2022 May 4.

Department Of Medical Parasitology, Faculty Of Medicine, Cairo University, Cairo Egypt.

Background: Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections.

Objective: Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole.

Methods: Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 mg/kg and were compared with control infected and non-infected mice. Read More

Front Microbiol 2022 3;13:859243. Epub 2022 May 3.

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China.

Trichinellosis is a serious zoonotic parasitic disease caused by () that causes considerable economic losses for the global pig breeding and food industries. As such, there is an urgent need for a vaccine that can prevent infection. Previous studies have reported that recombinant invasive (LL) expressing fibronectin binding protein A (LL-FnBPA+) can transfer DNA vaccines directly to dendritic cells (DCs) across an epithelial cell monolayer, leading to significantly higher amounts of heterologous protein expression compared to non-invasive . Read More

Front Cell Infect Microbiol 2022 26;12:882608. Epub 2022 Apr 26.

Center of Research Excellence in Therapeutic Proteins and Antibody Engineering, Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

, a tissue-dwelling helminth, causes human trichinellosis through ingestion of undercooked meat containing the parasite's infective larvae. However, benefits from infection have been documented: reduction of allergic diseases, inhibition of collagen-induced arthritis, delay of type 1 diabetes progression, and suppression of cancer cell proliferation. Since conventional cancer treatments have limited and unreliable efficacies with adverse side effects, novel adjunctive therapeutic agents and strategies are needed to enhance the overall treatment outcomes. Read More

Exp Parasitol 2022 Jul 11;238:108264. Epub 2022 May 11.

College of Veterinary Medicine, Jilin Agricultural University, Changchun, China; Jilin Provincial Engineering Research Center of Animal Probiotics, Jilin Provincial Key Laboratory of Animal Microecology and Healthy Breeding, Jilin Agricultural University, Changchun, China; Key Laboratory of Animal Production and Product Quality Safety of Ministry of Education, Jilin Agricultural University, Changchun, China. Electronic address:

Trichinellosis is a food-borne zoonotic parasitic disease that causes serious harm to human health and the pig breeding industry. However, there are reports that Trichinella spiralis (T. spiralis) infection can treat autoimmune diseases, including enteritis and experimental autoimmune encephalitis (EAE). Read More

PLoS Negl Trop Dis 2022 05 2;16(5):e0010395. Epub 2022 May 2.

Department of Parasitology, Medical College of Zhengzhou University, Zhengzhou, China.

Background: A range of helminth species involve the migration of developing larvae through the lung and establish chronic infections in the host that include potent immune regulatory effects. Trichinella spiralis is one of the most successful parasitic symbiotes. After released by intestinal female adult worms, newborn larvae of T. Read More

Food Waterborne Parasitol 2022 Jun 19;27:e00156. Epub 2022 Apr 19.

Department of Infectious Diseases, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome 00161, Italy.

The International Trichinella Reference Centre (ITRC) is the official laboratory of the International Commission on Trichinellosis, of the World Organization for Animal Health and of the European Union Reference Laboratory for Parasites. The ITRC was established in 1988 as a repository of strains and a source of reference materials and information for international scientific research. To date, more than 8000 isolates collected throughout the world have been identified at the species or genotype level by the ITRC staff and the information has been stored in a freely accessible database providing the largest collection of data available for scientists involved in the systematics and epidemiology of this parasite. Read More

Folia Parasitol (Praha) 2022 Apr 6;69. Epub 2022 Apr 6.

National Reference Laboratory for Trichinellosis (NRLT), Department for Immunology and Immunoparasitology, Institute for the Application of Nuclear Energy-INEP, University of Belgrade, Belgrade, Serbia.

An outbreak of trichinellosis occurred in Stari Banovci, a settlement in the municipality of Stara Pazova, Srem, Republic of Serbia, in March-April 2019. A total of 28 persons were exposed and trichinellosis was confirmed in 24 of them. This outbreak involved members of eight families, their relatives and friends. Read More

Trop Med Infect Dis 2022 Apr 7;7(4). Epub 2022 Apr 7.

International Livestock Research Institute, Hanoi 100000, Vietnam.

Trichinellosis and cysticercosis remain challenges to human health and animal productivity worldwide, especially in developing countries. While information on the occurrence of both diseases is infrequent, they are endemic in parts of Vietnam and mainly related to indigenous pigs kept by ethnic minorities. This study aimed to determine the seroprevalence and risk factors of both diseases in indigenous pigs and explore the perception and awareness of both human and pig trichinellosis and cysticercosis of pig farmers. Read More

Med Ultrason 2022 Apr 14. Epub 2022 Apr 14.

Rheumatology Division, Rehabilitation Clinical Hospital Cluj-Napoca.

Trichinellosis, a parasitosis transmitted through consumption of raw or undercooked meat from pigs and game animals, is responsible for a specific myositis. The calcifications of infected myocytes and larva can be detected during many years postin-fection. We present the case of a male patient with a history of severe trichinellosis with disease onset 30 years ago, presenting with generalized muscle microcalcifications detected during musculoskeletal ultrasound evaluation. Read More

Biomed Pharmacother 2022 Jun 12;150:112937. Epub 2022 Apr 12.

Servicio de Aparato Digestivo, Hospital General Universitario Gregorio Marañón-IiSGM, Spain; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Spain. Electronic address:

AHCC® is a standardized extract of cultured mushroom (Lentinula edodes) mycelia with a wide variety of therapeutic effects including anti-inflammatory, antitumor and antiviral effects. Trichinellosis, a food-borne parasitic zoonosis is caused by the nematode Trichinella spp. Infection with Trichinella is characterized by the induction of a Th1-type response at the beginning of the intestinal phase, followed by a dominant Th2-type response which is essential for parasite expulsion. Read More

Front Microbiol 2022 23;13:857786. Epub 2022 Mar 23.

Department of Human Parasitology, School of Basic Medicine, Hubei University of Medicine, Shiyan, China.

Trichinellosis caused by is a worldwide food-borne parasitic zoonosis. Several approaches have been performed to control infection, including veterinary vaccines, which contribute to improving animal health and increasing public health by preventing the transmission of trichinellosis from animals to humans. In the past several decades, many vaccine studies have been performed in effort to control infection by reducing the muscle larvae and adult worms burden. Read More

Transbound Emerg Dis 2022 Apr 10. Epub 2022 Apr 10.

Departamento de Patología y Medicina Preventiva, Facultad de Ciencias Veterinarias, Universidad de Concepción, Chillán, Chile.

The genus Trichinella has a worldwide distribution, infecting people, domestic animals, and wildlife. It includes 13 genotypes, which are geographically delimited; Trichinella is transmitted to people through the ingestion of undercooked meat. Historically, it has been associated with pigs, but most Trichinella species affect wildlife, and cases of trichinellosis due to the consumption of game meat have been emerging. Read More

Int Immunopharmacol 2022 Jul 25;108:108716. Epub 2022 Mar 25.

Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, China. Electronic address:

Trichinellosis is a serious food-borne parasitic zoonosis worldwide. Different host macrophage subsets play various roles during helminth infection; however, the dynamic changes in macrophage subsets following Trichinella spiralis infection have not been reported. Here, flow cytometry and immunofluorescence were used to assess macrophage activation in mesenteric lymph nodes (MLN), spleen, intestine, and muscle from T. Read More

Molecules 2022 Mar 17;27(6). Epub 2022 Mar 17.

Department of Fruit, Vegetable and Plant Nutraceutical Technology, Wrocław University of Environmental and Life Sciences, Chełmońskiego 37, 51-630 Wrocław, Poland.

Our experiment determined the immunotropic activity of a natural, iridoid-anthocyanin extract from honeysuckle berry ( L.) (LC). The extract was administered to mice infected with , orally at a dose of 2 g/kg bw, six times at 24 h intervals (from day 3 prior to the infection to day 3 post-infection (dpi) with . Read More

Parasitol Res 2022 May 23;121(5):1369-1378. Epub 2022 Mar 23.

UMR BIPAR, Anses, Laboratoire de Santé Animale, INRAE, Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, France.

The parasitic nematode Trichinella has a special relationship with its host as it has a unique intracellular location within the feeder cell which is a structure derived from skeletal muscle fiber. It has been proposed that "parakines" secreted by Trichinella larvae serve as messengers to implement communication between the parasite and the muscle cells through a molecular cross-talk to ensure permanent coexistence within the host. The Ts-NBL1 protein is considered to be a potential key "parakine" involved in the early invasion of the muscle fiber and its transformation into a feeder cell during Trichinella spiralis infection. Read More

J Appl Microbiol 2022 Jun 28;132(6):4430-4439. Epub 2022 Mar 28.

University of Veterinary Medicine and Pharmacy in Košice, Košice, Slovak Republic.

Aims: To study the local intestinal lymphocyte immunity in mice with trichinellosis affected by probiotic bacteria.

Methods And Results: Enterococcus faecium CCM8558, Enterococcus durans ED26E/7, Limosilactobacillus fermentum CCM7421 and Lactiplantibacillus plantarum 17 L/1 were administered daily (10  CFU ml ) and mice were infected with Trichinella spiralis (400 larvae) on the 7th day of treatment. T. Read More

Acta Trop 2022 Jun 15;230:106409. Epub 2022 Mar 15.

Public Health, Biostatistics and Community Medicine Department, Faculty of Medicine, Menoufia University, Egypt.

Trichinellosis is a zoonosis that causes health and economic problems worldwide. The available therapy is far from perfect as the conventional drugs used against Trichinella spiralis (T. spiralis) are active against the intestinal adult parasites but much less active against encapsulated larvae in muscles. Read More

J Parasit Dis 2022 Mar 19;46(1):24-36. Epub 2021 Jun 19.

Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Trichinellosis is a re-emerging zoonotic disease that has become a public health concern since its reported human outbreaks in many countries. The traditional therapy has many adverse effects in addition to the developing resistance. So, this necessitates finding effective natural alternatives. Read More

Travel Med Infect Dis 2022 May-Jun;47:102308. Epub 2022 Mar 9.

Amedeo di Savoia Hospital, ASL Città di Torino, Turin, Italy.

Background: Trichinellosis, a foodborne zoonosis due to nematodes of the genus Trichinella, occurs in the form of outbreaks following meat consumption. North Italy has been rarely involved. We report here the most significant wildlife derived trichinellosis outbreak ever registered in the Piedmont region. Read More

PLoS One 2022 10;17(3):e0265013. Epub 2022 Mar 10.

Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Trichinellosis is a zoonotic disease caused by the ingestion of the Trichinella nematode. With a worldwide incidence of approximately 10,000 cases per year, Trichinella spiralis is responsible for most human infections. There are no specific signs or symptoms of this parasitic infection. Read More

Vet Res 2022 Mar 7;53(1):19. Epub 2022 Mar 7.

Department of Parasitology, Medical College, Zhengzhou University, Zhengzhou, 450052, China.

The intestinal epithelium is the first natural barrier against Trichinella spiralis larval invasion, but the mechanism of larval invasion of the gut epithelium is not fully elucidated. The aim of this study was to investigate whether the excretory/secretory proteins (ESPs) of T. spiralis intestinal infective larvae (IIL) degrade tight junction (TJ) proteins, to assess the main ESP proteases hydrolysing TJ proteins using various enzyme inhibitors and to define the key invasive factors in IIL invasion of the gut epithelium. Read More

Acta Trop 2022 May 26;229:106388. Epub 2022 Feb 26.

Department of Parasitology, Medical College, Zhengzhou University, 40 Daxue Road, Zhengzhou 450052, China. Electronic address:

Trichinellosis is an important meat-borne zoonotic parasitic disease caused by ingesting raw or semi-cooked meat of pigs and other animals infected with Trichinella sp. muscle larvae. Epidemiological data on human and animal Trichinella sp. Read More

Parasite 2022 28;29:11. Epub 2022 Feb 28.

Faculty of Medicine, Saint-Joseph University, P.O. Box 11-5076 - Riad El Solh, 1107 2180 Beirut, Lebanon.

Background: Documented trichinellosis outbreaks in Lebanon date back to the late 19th century. The first published outbreaks were attributed to the consumption of wild boar meat, while those that followed incriminated pork. The practice of hunting wild boar is currently re-emerging in Lebanon given the recent economic crisis that has limited the purchase of livestock meat. Read More

Foods 2022 Feb 11;11(4). Epub 2022 Feb 11.

Department of Parasitology and Invasive Diseases, National Veterinary Research Institute in Pulawy, Al. Partyzantow 57, 24-100 Pulawy, Poland.

is a zoonotic disease caused by the nematodes of the genus . Infection takes place through the consumption of infected meat containing live larvae. The only way to prevent the disease is to break its epizootic chain. Read More