821 results match your criteria Trichiasis


Comparison of the efficacy of different cell sources for transplantation in total limbal stem cell deficiency.

Graefes Arch Clin Exp Ophthalmol 2019 Apr 19. Epub 2019 Apr 19.

State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, Shandong Eye Institute, Shandong Academy of Medical Sciences, 5 Yanerdao Road, Qingdao, 266071, China.

Purpose: The purpose of this study was to compare the efficacy of allogeneic cultured limbal epithelial transplantation (ACLET) and cultivated oral mucosal epithelial transplantation (COMET) in treating total limbal stem cell deficiency (LSCD).

Methods: In this retrospective cohort study, 73 patients (76 eyes) with total LSCD, including 41 patients (42 eyes) treated with ACLET and 32 patients (34 eyes) receiving COMET, were evaluated. The age, gender and injury cause of all patients were recorded. Read More

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http://dx.doi.org/10.1007/s00417-019-04316-zDOI Listing

Expression of prostaglandin E receptor 3 in the eyelid epidermis of patients with Stevens-Johnson syndrome/toxic epidermal necrolysis.

Br J Ophthalmol 2019 Apr 18. Epub 2019 Apr 18.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background/aims: In a previous genome-wide association study of Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) patients we reported the association between SJS/TEN and the prostaglandin E receptor 3 (PTGER3) gene, and that its protein PGE receptor 3 (EP3) was markedly downregulated in the conjunctival epithelium of SJS/TEN patients. Here we examined EP3 expression of the eyelid epidermis in SJS/TEN patients with severe ocular complications and investigated the function of EP3.

Methods: For the immunohistochemical study, we obtained eyelid samples from five SJS/TEN patients and five patients without SJS/TEN (control subjects) who were undergoing surgery to treat trichiasis, and investigated the expression of EP3 protein in the epidermis of those samples. Read More

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http://dx.doi.org/10.1136/bjophthalmol-2018-313587DOI Listing

Outcomes of Second Intention Healing of the Lower Eyelid Margin After Mohs Micrographic Surgery.

Dermatol Surg 2019 Mar 28. Epub 2019 Mar 28.

All authors are affiliated with Trieu Dermatology, Harvey, Louisiana and Derm Surgery Associates, Houston, Texas.

Background: Lower eyelid margin defects can be a reconstructive challenge. A possible alternative is second intention healing of the lower eyelid margin.

Objective: To determine the cosmetic outcomes and patient satisfaction of second intention healing of the lower eyelid margin after Mohs micrographic surgery (MMS). Read More

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http://dx.doi.org/10.1097/DSS.0000000000001951DOI Listing
March 2019
1 Read

The use of a combined sliding skin graft and a free labial mucocutaneous graft for reconstruction of the equine upper eyelid after full-thickness excision of a melanoma.

Clin Case Rep 2019 Mar 17;7(3):419-425. Epub 2019 Jan 17.

University Equine Hospital Leipzig University Leipzig Germany.

A melanoma of the upper eyelid was resected in a gray warmblood gelding. A full functional eyelid could be obtained by completion a sliding skin graft with a free labial mucocutaneous graft transplantation to restore the mucocutaneous junction and to decrease the risk of postoperative trichiasis. Read More

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http://dx.doi.org/10.1002/ccr3.1992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406139PMC

Various Manifestations Of Trachoma In Internally Displaced Rural Population - A Free Eye Camp Based Survey.

J Ayub Med Coll Abbottabad 2019 Jan-Mar;31(1):32-35

Army Field Hospital - Khaleefa Gulnawaz Teaching Hospital Bannu, Pakistan.

Background: The objective of the study is to observe frequency of various clinical manifestations of trachoma in rural population. This observational study was conducted at Khalifa Gul Nawaz Teaching Hospital (KGNTH), Bannu, Pakistan from April 2016 to Jan 2017.

Methods: Patients visiting for ocular complaints underwent initial screening that included demographic details and documentation of unaided as well as best corrected visual acuity (BCVA) which was followed by detailed slit lamp examination of anterior segment including eversion of upper lid for assessment of changes in upper tarsal conjunctivas by consultant ophthalmologist. Read More

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March 2019
4 Reads

Prevalence of Trachoma in Four Local Government Areas of Jigawa State, Nigeria.

Ophthalmic Epidemiol 2018 Dec;25(sup1):86-92

j Clinical Research Department , London School of Hygiene & Tropical Medicine , London , United Kingdom.

Purpose: To determine the prevalence of trachoma and water and sanitation coverage in four local government areas (LGAs) of Jigawa State, Nigeria: Birnin Kudu, Buji, Dutse and Kiyawa.

Methodology: A population-based cross-sectional survey was conducted in each LGA using Global Trachoma Mapping Project (GTMP) protocols. From each LGA, 25 villages were selected using probability-proportional-to-population size sampling; in each village, 25 households were selected using the random walk technique. Read More

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http://dx.doi.org/10.1080/09286586.2018.1467468DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444196PMC
December 2018

Prevalence of Trachoma in Kogi State, Nigeria: Results of four Local Government Area-Level Surveys from the Global Trachoma Mapping Project.

Ophthalmic Epidemiol 2018 Dec;25(sup1):33-40

e Department of Control of Neglected Tropical Diseases , World Health Organization , Geneva , Switzerland.

Purpose: To determine the prevalence of trachoma in four Local Government Areas (LGAs) of Kogi State, Nigeria.

Methods: In June 2014, we conducted population-based, cross-sectional surveys according to Global Trachoma Mapping Project (GTMP) protocols in selected LGAs of Kogi State. In each LGA, 25 clusters were selected with probability proportional to size. Read More

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http://dx.doi.org/10.1080/09286586.2017.1409359DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444201PMC
December 2018
2 Reads
1.271 Impact Factor

Prevalence of trachoma in the Afar Region of Ethiopia: results of seven population-based surveys from the Global Trachoma Mapping Project.

Ophthalmic Epidemiol 2018 Dec;25(sup1):3-10

b Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: Trachoma is to be eliminated as a public health problem by 2020. To help the process of planning interventions where needed, and to provide a baseline for later comparison, we set out to complete the map of trachoma in Afar, Ethiopia, by estimating trachoma prevalence in evaluation units (EUs) of grouped districts ("woredas").

Methods: We conducted seven community-based surveys from August to October 2013, using standardised Global Trachoma Mapping Project (GTMP) survey methodologies. Read More

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http://dx.doi.org/10.1080/09286586.2017.1362008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319167PMC
December 2018
1 Read

Epidemiology of trachoma and its implications for implementing the "SAFE" strategy in Somali Region, Ethiopia: results of 14 population-based prevalence surveys.

Ophthalmic Epidemiol 2018 Dec;25(sup1):25-32

c Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: Ethiopia is highly trachoma endemic. Baseline mapping was needed in Ethiopia's Somali Region to guide elimination efforts.

Methods: Cross-sectional community-based surveys were conducted in 34 suspected trachoma-endemic woredas, grouped as 14 evaluation units (EUs), using a standardised mapping methodology developed for the Global Trachoma Mapping Project. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2017.1
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http://dx.doi.org/10.1080/09286586.2017.1409358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444207PMC
December 2018
6 Reads

Prevalence of and risk factors for trachoma in Kwara state, Nigeria: Results of eight population-based surveys from the Global Trachoma Mapping Project.

Ophthalmic Epidemiol 2018 Dec;25(sup1):53-61

e Department of Control of Neglected Tropical Diseases , World Health Organization , Geneva , Switzerland.

Purpose: To determine the prevalence of and risk factors for trachoma in selected local government areas (LGAs) of Kwara State, Nigeria.

Methodology: Population-based cross-sectional surveys were conducted in eight LGAs of Kwara State using Global Trachoma Mapping Project (GTMP) protocols. In each LGA, 25 villages were selected using probability-proportional-to-size sampling; 25 households were selected from each village using compact segment sampling. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
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http://dx.doi.org/10.1080/09286586.2018.1437188DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444274PMC
December 2018
11 Reads
1.271 Impact Factor

Completing Baseline Mapping of Trachoma in Uganda: Results of 14 Population-Based Prevalence Surveys Conducted in 2014 and 2018.

Ophthalmic Epidemiol 2018 Dec;25(sup1):162-170

g RTI International , Dar es Salaam , Tanzania.

Purpose: We aimed to estimate the prevalence of trachomatous inflammation-follicular (TF) in children aged 1-9 years, trichiasis in adults aged ≥15 years, and water and sanitation (WASH) indicators in 12 suspected-endemic districts in Uganda.

Methods: Surveys were undertaken in 14 evaluation units (EUs) covering 12 districts. Districts were selected based on a desk review in 2014 (four districts) and trachoma rapid assessments in 2018 (eight districts). Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
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http://dx.doi.org/10.1080/09286586.2018.1546879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444199PMC
December 2018
11 Reads

Completing Baseline Mapping of Trachoma in Nepal: Results of 27 Population-Based Prevalence Surveys Conducted in 2013 and 2014.

Ophthalmic Epidemiol 2018 Dec;25(sup1):115-120

h Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: Trachoma is endemic in parts of Nepal; implementation of the surgery, antibiotics, facial cleanliness, environmental improvement (SAFE) strategy started in 2002. Some suspected-endemic districts had not previously been mapped. We aimed to estimate the prevalences of trachomatous inflammation-follicular (TF) and trichiasis in those districts. Read More

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http://dx.doi.org/10.1080/09286586.2018.1489972DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444275PMC
December 2018
1 Read
1.271 Impact Factor

Prevalence of Trachoma and Access to Water and Sanitation in Benue State, Nigeria: Results of 23 Population-Based Prevalence Surveys.

Ophthalmic Epidemiol 2018 Dec;25(sup1):79-85

m London Centre for Neglected Tropical Disease Research , London , United Kingdom.

Purpose: We sought to determine the prevalence of trachoma in each local government area (LGA) of Benue State, Nigeria.

Methods: Two-stage cluster sampling was used to conduct a series of 23 population-based prevalence surveys. LGAs were the evaluation units surveyed. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
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http://dx.doi.org/10.1080/09286586.2018.1467466DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444203PMC
December 2018
9 Reads
1.271 Impact Factor

Prevalence of trachoma in the Republic of Chad: results of 41 population-based surveys.

Ophthalmic Epidemiol 2018 Dec;25(sup1):143-154

i Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: To estimate the prevalence of trachoma in suspected-endemic areas of Chad, and thereby determine whether trachoma is a public health problem requiring intervention.

Methods: We divided the suspected-endemic population living in secure districts into 46 evaluation units (EUs), and used the standardized methodologies of the Global Trachoma Mapping Project. A two-stage cluster-sampling procedure was adopted. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
Publisher Site
http://dx.doi.org/10.1080/09286586.2018.1546877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444194PMC
December 2018
6 Reads

Prevalence of Trachoma in 47 Administrative Districts of Zambia: Results of 32 Population-Based Prevalence Surveys.

Ophthalmic Epidemiol 2018 Dec;25(sup1):171-180

s Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: A number of previous administrative-district-level baseline trachoma prevalence estimates in Zambia required verification. We used methodologies and systems for trachoma surveys considered to represent international best practice in order to generate reliable estimates of the prevalence of trachoma.

Methods: Between March 2016 and July 2017, we undertook 32 population-based prevalence surveys covering 47 administrative districts. Read More

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http://dx.doi.org/10.1080/09286586.2018.1546880DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444202PMC
December 2018
2 Reads

A Population-Based Trachoma Prevalence Survey Covering Seven Districts of Sangha and Likouala Departments, Republic of the Congo.

Ophthalmic Epidemiol 2018 Dec;25(sup1):155-161

e Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: We set out to estimate the prevalence of trachoma and access to water and sanitation in seven suspected-trachoma-endemic districts of northern Congo, surveyed as a single evaluation unit.

Methods: From a complete list of rural villages in the seven districts, we systematically selected 22 with probability proportional to village size. In selected villages, we included all households where there were fewer than 25 in total, or used compact segment sampling to select a group of approximately 20 households by random draw. Read More

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http://dx.doi.org/10.1080/09286586.2018.1546878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444200PMC
December 2018
1 Read

Progress Towards Elimination of Trachoma as a Public Health Problem in Eritrea: Results of a Systematic Review and Nine Population-based Prevalence Surveys Conducted in 2014.

Ophthalmic Epidemiol 2018 Dec;25(sup1):121-130

k Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: To assess Eritrea's progress towards elimination of trachoma as a public health problem, we reviewed and compiled current knowledge on the distribution and burden of trachoma in Eritrea, then undertook further population-based surveys where indicated, with support from the Global Trachoma Mapping Project (GTMP).

Methods: For the systematic review, undertaken in March 2014, we searched (1) PubMed, using the terms ((blind* or trachoma or trichiasis) AND Eritrea); (2) the online database of rapid assessments of avoidable blindness; (3) our own grey literature collections; and (4) the Global Atlas of Trachoma database. In June and July 2014, we conducted nine population-based prevalence surveys, for each of which 30 villages were systematically selected with probability proportional to population size; in each village, 30 households were systematically selected. Read More

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http://dx.doi.org/10.1080/09286586.2018.1545036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444204PMC
December 2018
1 Read

A search for trachoma in Timor-Leste: no evidence to justify undertaking population-based prevalence surveys.

Ophthalmic Epidemiol 2018 Dec;25(sup1):131-137

j Department of Control of Neglected Tropical Diseases , World Health Organization , Geneva , Switzerland.

Purpose: We sought evidence to justify undertaking population-based trachoma surveys in Timor-Leste, believing that in the absence of such evidence, the country could be categorized as not needing interventions to eliminate trachoma.

Methods: We undertook a systematic review of published literature on trachoma in Timor-Leste, with results updated to 28 April 2018. We also undertook a series of clinic- and field-based screening exercises, consisting of: (1) in October 2015, conjunctival examination of all children attending a school in Vila, Atauro Island; (2) from 1 November 2016 to 30 April 2017, examination for trichiasis, by specifically-trained frontline eye workers, of all individuals presenting to the ophthalmic clinics of six referral hospitals and five district eye clinics; and (3) house-to-house case searches in a total of 110 households, drawn from three communities that were reported by investigators from the 2016 Rapid Assessment of Avoidable Blindness (RAAB) to include residents with trachoma. Read More

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http://dx.doi.org/10.1080/09286586.2018.1545037DOI Listing
December 2018
1 Read

Use of an inexpensive magnifier with light source in the diagnosis of trichiasis among community-based case finders in Nigeria.

Ophthalmic Epidemiol 2018 Dec;25(sup1):138-142

c Kilimanjaro Centre for Community Ophthalmology, Division of Ophthalmology , University of Cape Town , Cape Town , South Africa.

Purpose: Trichiasis case finding is challenging in many trachoma endemic countries. We sought to determine how the use of an inexpensive hand-held magnifier with light source aids in the diagnosis of people with trichiasis.

Methods: We undertook a study on the use of the "Wilson", an inexpensive hand-held magnifier with light source between two groups of trained case finders: community drug distributors (CDD) volunteers and non-health volunteers. Read More

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http://dx.doi.org/10.1080/09286586.2018.1546876DOI Listing
December 2018

Prevalence of Trachoma in Senegal: Results of Baseline Surveys in 17 Districts.

Ophthalmic Epidemiol 2018 Dec;25(sup1):41-52

g Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: Senegal is endemic for trachoma, an infectious and potentially blinding eye disease. To complete the country's district-level baseline map of trachoma, we conducted population-based surveys in 17 health districts that were suspected-endemic but had yet to be surveyed.

Methods: We randomly selected 30 clusters (villages) per district and 30 households per village, and estimated the district-level prevalences of trachomatous inflammation-follicular (TF) in children aged 1-9 years, and trichiasis in persons aged ≥15 years. Read More

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http://dx.doi.org/10.1080/09286586.2017.1418897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444198PMC
December 2018
1 Read

Impact Survey Results after SAFE Strategy Implementation in 15 Local Government Areas of Kebbi, Sokoto and Zamfara States, Nigeria.

Ophthalmic Epidemiol 2018 Dec;25(sup1):103-114

n Clinical Research Department , London School of Hygiene & Tropical Medicine , London , United Kingdom.

Purpose: To determine prevalence of trachoma after interventions in 15 local government areas (LGAs) of Kebbi, Sokoto and Zamfara States, Nigeria.

Methods: A population-based impact survey was conducted in each LGA using Global Trachoma Mapping Project (GTMP) protocols. In each LGA, 25 villages were selected, except in Arewa LGA, where we selected 25 villages from each of four subunits to obtain finer-resolution prevalence information. Read More

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http://dx.doi.org/10.1080/09286586.2018.1481984DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444276PMC
December 2018
17 Reads
1.271 Impact Factor

Prevalence of trachoma in four marakez of Elmenia and Bani Suef Governorates, Egypt.

Ophthalmic Epidemiol 2018 Dec;25(sup1):70-78

o Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: In 2015, to determine where interventions are needed to eliminate trachoma as a public health problem from Egypt, we initiated population-based prevalence surveys using the Global Trachoma Mapping Project platform in four suspected-endemic marakez (districts; singular: markaz) of the governorates of Elmenia and Bani Suef.

Methods: In each markaz, 30 households were selected in each of 25 villages. Certified graders examined a total of 3682 children aged 1-9 years in 2993 households, noting the presence or absence of trachomatous inflammation-follicular (TF) and trachomatous inflammation-intense (TI) in each eye. Read More

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http://dx.doi.org/10.1080/09286586.2018.1446536DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444193PMC
December 2018
7 Reads

Prevalence of trachoma in Yemen: results of population-based prevalence surveys of 42 evaluation units in nine governorates.

Ophthalmic Epidemiol 2018 Dec;25(sup1):62-69

i Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: In suspected trachoma-endemic areas of Yemen, we sought to determine the prevalence of the sign trachomatous inflammation-follicular (TF) in children aged 1-9 years, and the potential individual and household risk factors for TF in that age group. We also sought to determine the prevalence of trichiasis in adults aged ≥15 years.

Methods: We conducted a cluster-sampled survey in each of 42 evaluation units (EUs) comprising 166 rural districts of nine Governorates (Adh Dhale'a, Al Hodeihah, Al Jawf, Hadramoot, Hajjah, Ibb, Lahj, Ma'rib, Taiz) using the Global Trachoma Mapping Project systems and methodologies. Read More

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http://dx.doi.org/10.1080/09286586.2018.1441426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444195PMC
December 2018
1 Read

Trachoma in Viet Nam: results of 11 surveillance surveys conducted with the Global Trachoma Mapping Project.

Ophthalmic Epidemiol 2018 Dec;25(sup1):93-102

k Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: Following interventions against trachoma in Viet Nam, impact surveys conducted in 2003-2011 suggested that trachoma was no longer a public health problem. In 2014, we undertook surveillance surveys to estimate prevalence of trachomatous inflammation-follicular (TF) and trichiasis.

Methods: A population-based prevalence survey was undertaken in 11 evaluation units (EUs) encompassing 24 districts, using Global Trachoma Mapping Project methods. Read More

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http://dx.doi.org/10.1080/09286586.2018.1477964DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444206PMC
December 2018
1 Read

Prevalence of trachoma in 13 Local Government Areas of Taraba State, Nigeria.

Ophthalmic Epidemiol 2018 Dec;25(sup1):18-24

k Clinical Research Department , London School of Hygiene & Tropical Medicine , London , United Kingdom.

Purpose: The purpose of these surveys was to determine the prevalence of trachomatous inflammation-follicular (TF) in children aged 1-9 years and trichiasis prevalence in persons aged ≥15 years, in 13 Local Government Areas (LGAs) of Taraba State, Nigeria.

Methods: The surveys followed Global Trachoma Mapping Project (GTMP) protocols. Twenty-five households were selected from each of 25 clusters in each LGA, using two-stage cluster sampling providing probability of selection proportional to cluster size. Read More

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http://dx.doi.org/10.1080/09286586.2017.1368670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444197PMC
December 2018
1 Read

Prevalence of trachoma in the area councils of the Federal Capital Territory, Nigeria: results of six population-based surveys.

Ophthalmic Epidemiol 2018 Dec;25(sup1):11-17

k Clinical Research Department , London School of Hygiene & Tropical Medicine , London , United Kingdom.

Purpose: The World Health Organization's (WHO's) global trachoma elimination programme recommends mapping of trachoma at district level for planning of elimination activities in affected populations. This study aimed to provide data on trachoma prevalence for the Area Councils of Nigeria's Federal Capital Territory (FCT).

Methods: Using the Global Trachoma Mapping Project (GTMP) protocols, in March and April 2014, we conducted a population-based cross-sectional survey in each of the six Area Councils of FCT. Read More

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http://dx.doi.org/10.1080/09286586.2017.1367409DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444205PMC
December 2018
2 Reads

Factors shaping the implementation of the SAFE strategy for trachoma using the Consolidated Framework for Implementation Research: a systematic review.

Glob Health Action 2019 ;12(1):1570646

b Department of Epidemiology and Biostatistics, School of Public Health , University of Zambia , Lusaka , Zambia.

Background: The SAFE strategy (surgery for trichiasis, antibiotics for active infection, facial cleanliness and environmental improvement) is the World Health Organization (WHO) recommended guideline for the elimination of blindness by trachoma by the year 2020.

Objective: While evaluations on the implementation of the SAFE strategy have been done, systematic reviews on the factors that have shaped implementation are lacking. This review sought to identify these factors. Read More

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http://dx.doi.org/10.1080/16549716.2019.1570646DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383623PMC
January 2019
1.646 Impact Factor

Assessment of trachoma in suspected endemic areas within 16 provinces in mainland China.

PLoS Negl Trop Dis 2019 01 28;13(1):e0007130. Epub 2019 Jan 28.

Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Beijing, China.

Background: China used to be among the countries with a high prevalence of trachoma. At the launch of The Global Elimination of Trachoma (GET) 2020 campaign by the World Health Organization (WHO) in 1996, China was placed on the list of countries endemic for trachoma based on historical data. However, empirical observation and routinely collected eye care data were suggesting that trachoma was no longer a public health problem. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6366720PMC
January 2019
3 Reads

3D images as a field grader training tool for trachomatous trichiasis: A diagnostic accuracy study in Ethiopia.

PLoS Negl Trop Dis 2019 01 24;13(1):e0007104. Epub 2019 Jan 24.

International Centre for Eye Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Background: Trachomatous trichiasis (TT) will continue to develop among those people who have had repeated infections after active trachoma is controlled. Detecting and treating affected individuals will remain necessary for years; a long "tail" of incident cases is anticipated. As the prevalence of TT declines, there will be fewer cases available for training trachoma graders (TG), necessitating alternative methods. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363231PMC
January 2019
10 Reads

Use of equine amniotic membrane free-island grafts for treatment of a midstromal corneal ulcer and descemetocele in a snow leopard (Panthera uncia).

J Am Vet Med Assoc 2018 Dec;253(12):1623-1629

CASE DESCRIPTION A 7-year-old sexually intact female snow leopard (Panthera uncia) was examined because of blepharospasm, periocular discharge, ventral deviation of the upper eyelid cilia, third eyelid prolapse, and corneal opacity of the right eye. CLINICAL FINDINGS An ophthalmic examination performed with the patient anesthetized revealed a 3 × 3-mm ulcer that extended approximately 60% of the depth of the right cornea and was accompanied by perilesional and intralesional cellular infiltrates and active vascularization. The upper eyelid of the right eye also had a previously repaired coloboma resulting in trichiasis. Read More

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https://avmajournals.avma.org/doi/10.2460/javma.253.12.1623
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http://dx.doi.org/10.2460/javma.253.12.1623DOI Listing
December 2018
14 Reads

Optimising age adjustment of trichiasis prevalence estimates using data from 162 standardised surveys from seven regions of Ethiopia.

Ophthalmic Epidemiol 2018 Dec 28:1-8. Epub 2018 Dec 28.

a Clinical Research Department , London School of Hygiene & Tropical Medicine , London , UK.

Purpose: The prevalence of trichiasis is higher in females and increases markedly with age. Surveys carried out in the daytime, particularly in developing countries, are prone to find older individuals and females at home at the time of the survey. Population-level trichiasis estimates should adjust sample proportions to reflect the demographic breakdown of the population, although the most accurate method of doing this is unclear. Read More

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https://www.tandfonline.com/doi/full/10.1080/09286586.2018.1
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http://dx.doi.org/10.1080/09286586.2018.1555262DOI Listing
December 2018
6 Reads
1.271 Impact Factor

Trachoma control: the SAFE strategy.

Int J Ophthalmol 2018 18;11(12):1887-1888. Epub 2018 Dec 18.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology & Vision Science Key Lab, Beijing 100730, China.

As a contagious bacterial infection that affects the conjunctival covering of the eye, the cornea and the eyelids, trachoma is controlled by an endorsed integrated strategy consisting of surgery for trichiasis, antibiotic therapy, facial cleanliness and environmental improvement, namely, the SAFE strategy developed by World Health Organization. Developed based on evidence from previous field trials and constantly modified in practice, SAFE strategy has greatly boosted the progress in trachoma control. Regardless of the fact that there are still many pending questions, national program coordinators are convinced that trachoma control initiative based on SAFE strategy would be effective. Read More

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http://www.ijo.cn/gjyken/ch/reader/view_abstract.aspx?file_n
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http://dx.doi.org/10.18240/ijo.2018.12.01DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6288535PMC
December 2018
12 Reads

Achieving the endgame: Integrated NTD case searches.

PLoS Negl Trop Dis 2018 12 20;12(12):e0006623. Epub 2018 Dec 20.

The Carter Center, Atlanta, Georgia, United States of America.

Trachoma and Guinea Worm Disease (GWD) are neglected tropical diseases (NTD) slated for elimination as a public health problem and eradication respectively by the World Health Organization. As these programs wind down, uncovering the last cases becomes an urgent priority. In 2010, Ghana Health Services, along with The Carter Center, Sightsavers, and other partners, conducted integrated case searches for both GWD and the last stage of trachoma disease, trachomatous trichiasis (TT), as well as providing surgical treatment for TT to meet elimination (and eradication targets). Read More

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http://dx.plos.org/10.1371/journal.pntd.0006623
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http://dx.doi.org/10.1371/journal.pntd.0006623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319769PMC
December 2018
14 Reads

Periocular Manifestations of Afatinib Therapy.

Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):e12-e13

Oxford University Hospital, Headley Way, Headington, Oxford, United Kingdom.

Epidermal growth factor receptor tyrosine kinase inhibitor therapy has been increasingly employed in the treatment of a variety of tumors. The authors report the rarely documented side effect of trichiasis with the use of Afatinib in a patient with spinal chordoma and review-related literature. A 67-year-old lady was referred to the oculoplastic service with a 3-month history of ocular irritation and pain associated with blurred vision. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001277DOI Listing
December 2018
2 Reads

Universal ocular screening of 481 infants using wide-field digital imaging system.

BMC Ophthalmol 2018 Oct 30;18(1):283. Epub 2018 Oct 30.

Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Lab, 1 Dongjiaominxiang, Dongcheng District, Beijing, 100730, China.

Background: Universal ocular screening of infants is not a standard procedure in children's health care system in China. This pilot study investigated prevalence of ocular abnormalities of 6 weeks-age infants using wide-field digital imaging system.

Methods: Infants aged 6 weeks around were consecutively enrolled in a public hospital between April 2015 and August 2016. Read More

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https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12
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http://dx.doi.org/10.1186/s12886-018-0943-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208088PMC
October 2018
23 Reads

Fluorometholone 0.1% as Ancillary Therapy for Trachomatous Trichiasis Surgery: Randomized Clinical Trial.

Am J Ophthalmol 2019 Jan 27;197:145-155. Epub 2018 Sep 27.

Eye Department, Shashemene Referral Hospital, Shashemene, Ethiopia; The Fred Hollows Foundation, Addis Ababa, Ethiopia.

Purpose: To assess the hypothesis that fluorometholone 0.1% eye drops are safe and effective as adjunctive therapy for trachomatous trichiasis (TT) surgery; determining the most promising dose.

Design: Randomized, placebo-controlled, double-masked parallel dose-ranging clinical trial. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00029394183053
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http://dx.doi.org/10.1016/j.ajo.2018.09.017DOI Listing
January 2019
6 Reads

Trachoma prevalence remains below threshold in five districts after stopping mass drug administration: results of five surveillance surveys within a hyperendemic setting in Amhara, Ethiopia.

Trans R Soc Trop Med Hyg 2018 Dec;112(12):538-545

Trachoma Control Program, The Carter Center, Atlanta, GA, USA.

Background: The World Health Organization (WHO) recommends conducting trachoma surveillance surveys in districts where the elimination targets have been met and following a minimum 2-year period after cessation of mass drug administration (MDA) in order to determine the sustainability of low trachoma levels.

Methods: In 2015, population-based surveillance surveys were conducted in five districts of Amhara, Ethiopia. All five districts had a prior trachomatous inflammation-follicular (TF) prevalence among children 1-9 y of age of <5% determined by an impact survey and had not received MDA for ≥2 y. Read More

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http://dx.doi.org/10.1093/trstmh/try096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6255692PMC
December 2018
5 Reads

The proportion of ocular surface diseases in untreated patients with epiphora.

Clin Ophthalmol 2018 11;12:1769-1773. Epub 2018 Sep 11.

Department of Ophthalmology, Saitama Medical University, Saitama, Japan,

Purpose: Various ocular surface disorders, such as dry eye, infectious and non-infectious inflammation, anatomical anomalies in lid structure, and/or obstruction of the tear outflow tract, can cause epiphora. However, few reports have described the proportions of causative diseases in patients with epiphora. Therefore, we investigated the frequent causes of epiphora in older adult patients. Read More

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http://dx.doi.org/10.2147/OPTH.S172503DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141122PMC
September 2018
1 Read

An impact evaluation of two rounds of mass drug administration on the prevalence of active trachoma: A clustered cross sectional survey.

PLoS One 2018 29;13(8):e0201911. Epub 2018 Aug 29.

Health Education Unit, Education Department, Eugenio María de Hostos Community College, The City University of New York, New York, NY, United States.

Introduction: We investigated the impact of two round of mass drug administration on trachoma prevalence in Plateau and Nasarawa States of Nigeria. The mass drug administration was conducted as a component of the SAFE Strategy, a combination of interventions recommended for the global elimination of blinding trachoma.

Methods: The study consisted of a two-stage cross-sectional clustered sample survey in which 3990 people from 793 households were screened for clinical signs of trachoma. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0201911PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6114510PMC
February 2019
22 Reads

A diagnostic instrument to help field graders evaluate active trachoma.

Ophthalmic Epidemiol 2018 Oct - Dec;25(5-6):399-402. Epub 2018 Aug 1.

c School of Medicine , University of St Andrews , St Andrews , UK.

The SAFE strategy (Surgery for trichiasis, mass treatment with Antibiotics to clear ocular Chlamydia trachomatis infection, and Facial cleanliness and Environmental improvement to reduce transmission) is being used to eliminate trachoma as a public health problem. Decisions on whether or not to implement the A, F, and E components of SAFE are made on the basis of the prevalence of trachomatous inflammation-follicular (TF) in 1-9-year-olds. TF has a precise definition: at least five follicles, each of which is at least 0. Read More

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http://dx.doi.org/10.1080/09286586.2018.1500616DOI Listing
March 2019
2 Reads

Determinants for not utilizing trachomatous trichiasis surgery among trachomatous trichiasis patients in Mehalsayint District, North-East Ethiopia.

PLoS Negl Trop Dis 2018 07 18;12(7):e0006669. Epub 2018 Jul 18.

Department of Health Information Technology, Dessie Health Science College, Dessie, Ethiopia.

Background: Globally, trachoma is the leading cause of infectious blindness. In Ethiopia, the overall Trachomatous Trichiasis (TT) surgical coverage is 41%. Identifying determinants for not utilizing TT surgery among TT patients is important to design and monitor effective intervention programs. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006669DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066252PMC
July 2018
1 Read

Efficacy of Inverted "V" Release Surgery in the Correction of a Special Type of Epicanthus.

Aesthetic Plast Surg 2018 Oct 10;42(5):1304-1311. Epub 2018 Jul 10.

Aier School of Ophthalmology, Central South University, Changsha, 410015, China.

Objective: To evaluate the efficacy of a new correction method (inverted "V" release surgery) for epicanthus as a cause of congenital entropion/trichiasis in the lower eyelid.

Methods: From May 2014 to May 2017, 60 eyes of 30 patients (13 male and 17 female patients, with the age of 6.85 ± 4. Read More

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http://dx.doi.org/10.1007/s00266-018-1190-2DOI Listing
October 2018
21 Reads

Trachoma elimination, approaching 2020.

Curr Opin Ophthalmol 2018 Sep;29(5):451-457

Department of Ophthalmology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.

Purpose Of Review: To review current practices for trachoma treatment with a focus on recent studies, particularly those discussing trachoma trichiasis surgery.

Recent Findings: Azithromycin eye drops twice daily for 3 days may be as efficient as oral azithromycin in treating active trachoma. Facial cleanliness and environmental improvement programming should employ a variety of behavior change techniques to give sustained improvements. Read More

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http://dx.doi.org/10.1097/ICU.0000000000000504DOI Listing
September 2018
12 Reads

Cicatricial ectropion surgery: a prospective study of long-term symptom control, patient satisfaction and anatomical success.

Clin Exp Ophthalmol 2018 Dec 8;46(9):1002-1007. Epub 2018 Jul 8.

Department of Ophthalmology, Waikato Hospital, Hamilton, New Zealand.

Importance: Cicatricial ectropion repair is effective and has a low complication rate.

Background: To evaluate the effectiveness and long-term functional outcomes of surgical repair of lower lid cicatricial ectropion.

Design: Prospective consecutive case series. Read More

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http://dx.doi.org/10.1111/ceo.13338DOI Listing
December 2018
6 Reads

Why do patients refuse trichiasis surgery? Lessons and an education initiative from Mtwara Region, Tanzania.

PLoS Negl Trop Dis 2018 06 14;12(6):e0006464. Epub 2018 Jun 14.

Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.

Background: Trachomatous trichiasis is one of the leading causes of preventable blindness worldwide. A relatively simple surgery can spare vision. Although this surgery is usually performed free of charge in endemic regions, multiple studies indicate that surgical refusal is common. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006464DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6001945PMC
June 2018
3 Reads

Baseline trachoma prevalence in Guinea: Results of national trachoma mapping in 31 health districts.

PLoS Negl Trop Dis 2018 06 11;12(6):e0006585. Epub 2018 Jun 11.

Regional office for Africa, Helen Keller International, Dakar, Senegal.

Background: Based on previous studies, historical records and risk factors, trachoma was suspected to be endemic in 31 health districts (HDs) in Guinea. To facilitate planning for the elimination of trachoma as a public health problem, national trachoma surveys were conducted between 2011 and 2016 to determine the prevalence of trachomatous inflammation-follicular (TF) and trachomatous trichiasis (TT) in all 31 endemic HDs.

Methodology/principal Findings: A total of 27 cross-sectional surveys were conducted, each using two-stage cluster sampling (one survey in 2011 covered five HDs). Read More

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http://dx.doi.org/10.1371/journal.pntd.0006585DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013237PMC
June 2018
7 Reads

Histopathologic Findings of Linear Scleroderma Displaying Focal Trichiasis Secondary to Tarsal Thinning.

Ophthalmic Plast Reconstr Surg 2018 Jul/Aug;34(4):e124-e127

Department of Ophthalmology, Ophthalmic Plastic Surgery, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, U.S.A.

Linear scleroderma en coup de sabre with ophthalmic findings has been previously described in the literature on numerous occasions. A 57-year-old woman presented with focal trichiasis secondary to tarsal thinning, adjacent to a linear brow and forehead deformity consistent with linear scleroderma en coup de sabre. Cases of linear scleroderma en coup de sabre involving the eyelids have been reported, most often with madarosis, ptosis, or skin atrophy; however, to the authors' knowledge, this is the first reported case of linear scleroderma associated with trichiasis and involvement of the deeper eyelid tissues, particularly the tarsus. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001140DOI Listing
August 2018
8 Reads

A review of scoring systems for ocular involvement in chronic cutaneous bullous diseases.

Orphanet J Rare Dis 2018 05 22;13(1):83. Epub 2018 May 22.

Faculty of Medicine, University of New South Wales, Sydney, 2052, Australia.

Background: Epidermolysis bullosa (EB) and autoimmune blistering diseases (AIBD) describe a group of rare chronic dermatoses characterized by cutaneous fragility and blistering. Although uncommon, significant ocular surface disease (OSD) may occur in both and require ophthalmological assessment. Disease scoring systems have a critical role in providing objective and accurate assessment of disease severity. Read More

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https://ojrd.biomedcentral.com/articles/10.1186/s13023-018-0
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http://dx.doi.org/10.1186/s13023-018-0823-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5964694PMC
May 2018
13 Reads

Trachoma in Yunnan province of southwestern China: findings from trachoma rapid assessment.

BMC Ophthalmol 2018 Apr 17;18(1):97. Epub 2018 Apr 17.

Department of Ophthalmology, Yunnan Key Laboratory for prevention and treatment of eye diseases, Yunnan Innovation Team for Cataract and Ocular fundus Disease (2017HC010), Yunnan Eye Institute, Yunnan Eye Hospital, The 2nd People's Hospital of Yunnan Province, Kunming, China.

Background: To understand the situation of active trachoma among children aged 6 to 8 years old and scarring trachoma among those aged 15 and over in Yunnan Province, South-western China.

Methods: A rapid assessment of trachoma was conducted to determine the presence or absence of trachoma in Yunnan. Through risk assessment, 9 sites in 8 suspected trachoma epidemic counties were selected. Read More

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http://dx.doi.org/10.1186/s12886-018-0759-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5902944PMC
April 2018
6 Reads

Oral doxycycline for the prevention of postoperative trachomatous trichiasis in Ethiopia: a randomised, double-blind, placebo-controlled trial.

Lancet Glob Health 2018 05;6(5):e579-e592

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: Trachomatous trichiasis is treated surgically to prevent sight loss. Unfavourable surgical outcomes remain a major challenge. We investigated the hypothesis that doxycycline might reduce the risk of postoperative trichiasis following surgery in patients with trachomatous trichiasis through anti-matrix metalloproteinase and anti-inflammatory activity. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2214109X183011
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http://dx.doi.org/10.1016/S2214-109X(18)30111-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912946PMC
May 2018
12 Reads