Search Our Scientific Publications & Authors

Plast Reconstr Surg Glob Open 2021 Mar 22;9(3):e3480. Epub 2021 Mar 22.

Department of Plastic Reconstructive and Aesthetic Surgery, Koç University, Istanbul, Turkey.

Trichiasis is an acquired condition in which eyelashes are misdirected toward the ocular surface, resulting in eye irritation and ocular morbidities. Different treatment modalities have been described, including surgical and non-surgical methods. The goal of this article is to present a novel technique for treatment of trichiasis, with a brief review of treatment options. Read More

Am J Ophthalmol 2021 Apr 24. Epub 2021 Apr 24.

Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Purpose: This study is aimed at comparing the effects of Tea Tree Oil shampoo (TTO) with regular-lid shampoo on the treatment of meibomian gland dysfunction (MGD) signs and symptoms.

Design: Double-masked randomized clinical trial METHODOLOGY: Forty patients with MGD were treated by daily lid scrubbing with TTO shampoo in one eye and regular-lid shampoo in the other one. Before treatment and then after 1 and 3 months, the effect on ocular surface symptoms, tear production and stability, and conjunctival and lid signs of the two eyes were compared. Read More

Eur J Ophthalmol 2021 Mar 28:11206721211006643. Epub 2021 Mar 28.

Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA.

Purpose: There is an increased risk for development of blepharoptosis after incisional glaucoma surgery. Data on safety and efficacy of ptosis repair in this group of patients in limited. The goal of this study is to evaluate outcomes and identify potential risk factors for failure of ptosis repair in eyes with history of incisional glaucoma surgery. Read More

Clin Case Rep 2021 Mar 13;9(3):1299-1303. Epub 2021 Jan 13.

Mississippi State University College of Veterinary Medicine MSU MS USA.

Utilization of the Hotz-Celsus technique with standing sedation and local nerve blocks in cattle provides adequate correction of cicatricial entropion. Read More

BMC Med Educ 2021 Mar 19;21(1):170. Epub 2021 Mar 19.

Department of Ophthalmology and Visual Sciences, University of Maryland School of Medicine, 419 W. Redwood St., Suite 420, Baltimore, MD, 21201, USA.

Background: Repair of margin-involving eyelid lacerations is a challenge for beginning ophthalmology residents, yet no commercially-available simulation models exist for learning this skill. The objective of the study was to modify a mannequin-based surgical simulator originally developed for trachomatous trichiasis surgery training to teach margin-involving eyelid laceration repair and to evaluate its success within a residency wet-lab environment.

Methods: We modified a previously developed mannequin-based training system for trachomatous trichiasis surgery into a simulator for margin-involving eyelid laceration repair. Read More

PLoS One 2021 19;16(3):e0247994. Epub 2021 Mar 19.

Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD, United States of America.

Background: Post-surgical follow-up is a challenge in low- and middle-income countries. Understanding barriers to trachomatous trichiasis (TT) surgical follow-up can inform program improvements. In this study, patient perceived barriers and enabling factors to follow-up after TT surgery are identified. Read More

Ophthalmologe 2021 Apr 8;118(4):404-412. Epub 2021 Mar 8.

Klinik für Augenheilkunde, Uniklinik RWTH Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

Objective: The aim of simple limbal epithelial transplantation (SLET) is the regeneration of the corneal surface in unilateral complete limbal stem cell deficiency (LSCD).

Indications: SLET is indicated for unilateral complete LSCD.

Contraindications: Contraindications include bilateral LSCD, severe corneal thinning, pronounced keratoconjunctivitis sicca, chronic inflammatory condition of the ocular surface, malposition of the eyelids and pronounced adhesions of the conjunctiva with trichiasis. Read More

Eur J Ophthalmol 2021 Feb 25:1120672121998914. Epub 2021 Feb 25.

Ophthalmology Department, Hospital Universitario Ramón y Cajal, IRYCIS, Madrid, Spain.

Purpose: To present the benefits of the addition of a conjunctival flap when correcting lower eyelid retraction using an auricular cartilage graft.

Methods: An auricular cartilage graft was obtained either from the concha o the scaphoid fossa. When preparing the receiving bed, the conjunctival incision was made 2 mm below the inferior margin of the lower eyelid tarsus, therefore, a conjunctival flap arising from the inferior border of the tarsus was obtained. Read More

Eur J Ophthalmol 2021 Feb 18:1120672121996637. Epub 2021 Feb 18.

Research Group in Neurosciences NeURos, Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To present a rare and novel association of Ocular Cicatricial Pemphigoid, Sjögren's Syndrome, and Hashimoto's Thyroiditis as a Multiple Autoimmune Syndrome.

Case Report: A 43-year-old Colombian female, presented with corneal ulcers, associated with trichiasis. At the ophthalmological examination forniceal shortening OU and symblepharon OD was found. Read More

Microorganisms 2021 Jan 27;9(2). Epub 2021 Jan 27.

Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto 602-0841, Japan.

species are commonly found in the conjunctiva of healthy adults and are recognized as non-pathogenic bacteria. In recent years, however, species have been reported to be potentially pathogenic in various tissues. We investigated species on the ocular surface and reviewed various species of in terms of their antimicrobial susceptibility and the underlying molecular resistance mechanisms. Read More

PLoS Negl Trop Dis 2021 01 28;15(1):e0009082. Epub 2021 Jan 28.

Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Introduction: A number of neglected tropical diseases are targeted for elimination or eradication. An effective surveillance system is critical to determine if these goals have been achieved and maintained. Trachoma has two related but morphologically different presentations that are monitored for elimination, the active infectious form of trachoma and trachomatous trichiasis (TT), the progression of the disease. Read More

Afr Health Sci 2020 Mar;20(1):182-189

School of Medicine, University of Notre Dame Australia, 160 Oxford St Darlinghurst NSW 2010 Australia.

Background: Burundi is currently not meeting targets for elimination of trachoma and trichiasis by 2020 (GET2020). The recommended SAFE strategy (Surgery, antibiotics, face washing and environmental improvement) is currently not fully implemented in many areas of Burundi. The existence of associations between face-washing, sanitation and trachoma prevalence remain undocumented. Read More

PLoS Negl Trop Dis 2020 12 14;14(12):e0008882. Epub 2020 Dec 14.

Clinical Research Department, International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Background: WHO endorsed the use of epilation as an alternative treatment to surgery for the management of both minor unoperated TT (UTT) and postoperative TT (PTT). However, some trachoma control programmes hesitated to implement epilation citing concerns that it would hamper TT surgical acceptance and result in larger numbers of and stiffer trichiatic eyelashes than the original TT lashes. We investigated the burden and phenotypes of post-epilation trichiatic eyelashes, and willingness to accept surgical management separately in unoperated and postoperative TT cases. Read More

Cornea 2020 Dec 3. Epub 2020 Dec 3.

Department of Ophthalmology, Mayo Clinic, Rochester, MN.

Purpose: To describe the management and outcome of an ocular surface alkali burn in the setting of previous laser in situ keratomileusis (LASIK).

Methods: This is a case report and review of relevant literature.

Results: A 25-year-old man with a history of LASIK presented 4 weeks after a sodium hydroxide splash to his left eye with visual acuity of 20/60 and a nonhealing epithelial defect adjacent to sectoral inferior limbal ischemia in the setting of trichiasis from upper eyelid cicatricial entropion. Read More

Eye (Lond) 2020 Nov 24. Epub 2020 Nov 24.

Department of Ophthalmology, Cullen Eye Institute,Baylor College of Medicine, Houston, Texas, USA.

Purpose: To describe the lid characteristics of recurrent upper eyelid trachomatous entropion and to report the long-term outcomes of a five-step surgical approach based on the principles of upper eyelid crease lamellar splitting and retractor release with redirection.

Subjects And Methods: Retrospective case review of adult patients with recurrent upper eyelid trachomatous entropion who had undergone surgical correction using the five-step surgical technique between March 2014 and March 2018. Cases with primary entropion and/or <2 years of follow-up were excluded from this series. Read More

Ophthalmic Plast Reconstr Surg 2020 Nov 19. Epub 2020 Nov 19.

Discipline of Ophthalmology and Visual Sciences, The University of Adelaide.

A 46-year-old male presented with a 12-month history of trichiasis and was found to have significant, progressive cicatrization of the tarsal conjunctiva causing entropion of the upper and lower eyelids. A biopsy confirmed the diagnosis of IgG4-related cicatrizing conjunctivitis in the absence of any other organ involvement, a previously unreported manifestation of this immune-mediated disease. Read More

BMC Ophthalmol 2020 Nov 17;20(1):451. Epub 2020 Nov 17.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Surgery for trichiasis is one of the pillars of the World Health Organization's strategy for global elimination of trachoma as a public health problem. A high incidence of post-operative trichiasis or other poor surgical outcomes could jeopardize these efforts. In this review, we aimed to summarize the reported incidence of post-operative trichiasis and other poor outcomes of trichiasis surgery in Africa. Read More

Asia Pac J Ophthalmol (Phila) 2020 Dec;9(6):524-532

Singapore General Hospital, Singapore.

Therapeutic contact lenses (TCLs) are often used in the management of a wide variety of corneal and ocular surface diseases (OSDs). Indications of TCL include pain relief, enhancing corneal healing, corneal sealing, corneal protection, and drug delivery. For painful corneal diseases such as bullous keratopathy, epidermolysis bullosa, and epithelial abrasions/erosions, bandage contact lenses (BCLs) provide symptomatic relief. Read More

Bull World Health Organ 2020 Oct 3;98(10):698-705. Epub 2020 Sep 3.

International Centre for Eye Health, London School of Hygiene & Tropical Medicine, London, England.

A simplified grading system for trachoma was published by the World Health Organization (WHO) in 1987. Intended for use by non-specialist personnel working at community level, the system includes five signs, each of which can be present or absent in any eye: (i) trachomatous trichiasis; (ii) corneal opacity; (iii) trachomatous inflammation-follicular; (iv) trachomatous inflammation-intense; and (v) trachomatous scarring. Though neither perfectly sensitive nor perfectly specific for trachoma, these signs have been essential tools for identifying populations that need interventions to eliminate trachoma as a public health problem. Read More

Eur J Ophthalmol 2020 Nov 6:1120672120964112. Epub 2020 Nov 6.

Goldschleger Eye Institute, Sheba Medical Center, Tel-Hashomer, Israel.

Objective: To examine the clinical differences in manifestation, treatment, and prognosis of thyroid-eye-disease (TED) between men and women.

Methods: This is a longitudinal cohort study. Men and women, who diagnosed with TED and treated at a multidisciplinary TED clinic, were compared regarding differences in demographics, eye examination, disease activity, and quality of life evaluation. Read More

Clin Exp Optom 2021 Mar;104(2):233-236

Richard Lindsay and Associates, Level 5, 376 Albert Street, East Melbourne, Australia.

Sci Rep 2020 10 19;10(1):17703. Epub 2020 Oct 19.

Department of Education and Research, Taipei City Hospital, Taipei, Taiwan.

The aim of this study was to conduct a nationwide survey of the use of emergency ophthalmology services using a sub-dataset of one million beneficiaries sampled from Taiwan's National Health Insurance Research Database (NHIRD) for the years 2008 through 2012. By analyzing this population dataset, the study illustrates the disease landscape of emergency eye care services. The five-year, one-million-person NHIRD sub-dataset for 2008 through 2012 was used to explore emergency visits and ophthalmology specialty visits and to analyze the associated demographics and diagnosis codes based on the International Classification of Diseases, 9th Revision, Clinical Modification (ICD-9-CM). Read More

J Plast Reconstr Aesthet Surg 2021 02 20;74(2):382-386. Epub 2020 Sep 20.

Department of Ophthalmology, Tongji Hospital, Tongji University School of Medicine, 389 Xin Cun Road, Shanghai 200065, China. Electronic address:

Objective: To report outcomes of a surgical technique of eyelid margin splitting and anterior lamellar repositioning with lower eyelid non-entropion trichiasis.

Method: A total of 13 patients (5 males and 8 females) with lower eyelid non-entropion trichiasis who had undergone eyelid margin splitting and anterior lamellar repositioning at Tongji Hospital from January 2018 to June 2018 were retrospectively reviewed.

Result: All patients underwent surgery successfully, and 13 patients (23 eyes) were followed up for 9-18 months (mean 12. Read More

Orbit 2020 Sep 29:1-11. Epub 2020 Sep 29.

Department of Ophthalmology and Visual Sciences, College of Medicine, University of Illinois at Chicago, Chicago, USA.

Purpose: The reconstruction of large (>50%) upper eyelid margin defects can be technically challenging, with multiple approaches described in the literature. We sought to review the recent literature for new techniques or modifications to existing techniques.

Methods: We conducted a Pubmed search for technique papers on the reconstruction of large upper eyelid defects published within the past ten years with a minimum of four patients. Read More

Ophthalmologe 2020 Sep;117(9):949-961

Augenklinik, Ludwig-Maximilians-Universität München, Mathildenstr. 8, 80336, München, Deutschland.

Corneal changes associated with eyelid disease are frequent and can considerably complicate the course of the disease. They can manifest as refraction anomalies, corneal degeneration, ocular surface disease, corneal infiltrates, corneal vascularization and corneal ulceration up to corneal perforation. Pathophysiologically relevant are compressive forces, exposure, trichiasis and distichiasis, eye rubbing, inflammation and infection. Read More

Clin Ophthalmol 2020 22;14:2043-2050. Epub 2020 Jul 22.

Department of Ophthalmology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt.

Purpose: To compare the outcomes of anterior lamellar recession (ALR) versus posterior lamellar tarsal rotation (PLTR) procedure for the repair of lower eyelid trachomatous trichiasis (TT).

Design: Prospective randomized comparative trial.

Methods: Study Population and Interventions: Patients with lower eyelid TT were enrolled. Read More

Cureus 2020 Jul 29;12(7):e9450. Epub 2020 Jul 29.

Medicine, Imperial College London, London, GBR.

Trachoma is a neglected tropical disease that causes an eye infection which can lead to blindness if left untreated. In 1998, the World Health Organisation (WHO) launched a new goal to eradicate trachoma by 2020. Over the years, in partnership with the WHO, an effective strategy plan was devised to help tackle and control the disease. Read More

BMC Ophthalmol 2020 Aug 4;20(1):318. Epub 2020 Aug 4.

Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai, 200062, China.

Background: To report refractive outcomes, describe types of strabismus and evaluate the outcomes of surgical intervention for unilateral coronal synostosis (UCS) in paediatric patients.

Methods: This study retrospectively included 30 UCS cases. Patients aged from 3 months to 6 years (median: 1. Read More

Br J Ophthalmol 2020 Jul 26. Epub 2020 Jul 26.

Department of Control of Neglected Tropical Diseases, World Health Organization, Geneva, Switzerland.

Background: Poor outcomes of trichiasis surgery, including postoperative trichiasis, are common in many trachoma-endemic countries in Africa. To improve outcomes, WHO recommends regular follow-up and outcome assessment of surgical cases plus audit of trichiasis surgeons.

Aims: To assess national approaches to trichiasis surgical follow-up, outcome assessment and audit, and identify national targets for good surgical outcome (defined as the percentage of patients undergoing surgery for trichiasis remaining free of post-operative trichiasis for a defined interval after surgery). Read More

Am J Ophthalmol Case Rep 2020 Sep 9;19:100818. Epub 2020 Jul 9.

Division of Ophthalmology, Department of Surgery, Prisma Health - Upstate, 104 Simpson Street, Greenville, SC, 29605, USA.

Purpose: Present two patients on two different novel FGFR inhibitors who developed trichiasis with dry eye syndrome.

Observations: Two patients developed trichiasis and dry eye following FGFR inhibitor therapy. Treatments included artificial tears, lifitegrast or cyclosporine, and epilation as needed. Read More