146 results match your criteria Treponematosis Endemic Syphilis
J Clin Microbiol 2018 Oct 31. Epub 2018 Oct 31.
National Hospital Organization, Nagoya Medical Center, Department of Clinical Laboratory, Nagoya, Japan.
Human treponematosis is caused by various pathogenic sub-species (subsp.), including (TPA), (TPE), (TEN), and The global prevalence of syphilis has been increasing since the 2000s. Men account for more than 90% of the cases, with the majority being men who have sex with men (MSM). Read More
Clin Microbiol Infect 2018 Nov 16;24(11):1210.e1-1210.e5. Epub 2018 Feb 16.
Department of Biology, Masaryk University, Brno, 625 00, Czech Republic. Electronic address:
Objectives: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. Read More
Med Microbiol Immunol 2017 Aug 22;206(4):287-293. Epub 2017 Apr 22.
Max von Pettenkofer Institute, National Reference Centre for Retroviruses, Ludwig-Maximilians-University of München, Pettenkofer Str 9A, 80336, Munich, Germany.
Transmission of infectious agents might be associated with iatrogenic actions of charitable help in health care. An example is the vaccination against yellow fever in USA that transmitted hepatitis B virus. Another example is injections of praziquantel for treatment and cure of schistosomiasis in Central and Northern Africa, with a focus in Egypt that has spread hepatitis C virus. Read More
Vet Clin North Am Exot Anim Pract 2016 Sep;19(3):737-56
Sydney Exotics and Rabbit Vets, 64 Atchison Street, Crows Nest, New South Wales 2065, Australia.
The first part of this review focuses on the anatomy and physiology of the rabbit mouth. Practical understanding is critical to comprehend the dynamic pathologic changes of dental disease, which is one of the most common presenting problems in rabbits. The major theories of the etiopathogenesis of dental disease are presented. Read More
Int J Paleopathol 2016 Mar 25;12:11-16. Epub 2015 Nov 25.
Departamento de Biologia, Escola de Ciências e Tecnologia, Universidade de Évora, Évora 7002-554, Portugal; Centro de Investigação em Antropologia e Saúde (CIAS), Universidade de Coimbra, Apartado 3046, Coimbra 3001-401, Portugal. Electronic address:
Hypertrophic osteoarthropathy (HOA) is a bone pathology that can be associated with a number of focal or systemic diseases, particularly those affecting the respiratory system. HOA is characterized by proliferative periostosis of the long bones, especially in their distal and periarticular regions. This report presents a probable case of HOA in the skeleton of an elderly Portuguese male from Évora, Portugal, who died in 1970. Read More
Indian J Med Res 2015 May;141(5):608-13
Epidemiology & Epidemic Intelligence Service (EIS), National Centre for Disease Control (NCDC), Delhi, India.
Yaws, a non-venereal treponematosis, affecting primarily the tribal populations, has been considered historically as one of the most neglected tropical diseases in the world. In 1996, India piloted an initiative to eradicate yaws based on a strategy consisting of active case finding through house-to-house search and treatment of cases and their contacts with long acting penicillin. Thereafter, the campaign implemented in all 51 endemic districts in 10 states of the country led to the achievement of a yaws-free status in 2004. Read More
Am J Phys Anthropol 2015 Jan 6;156(1):90-101. Epub 2014 Oct 6.
Museum of London Archaeology, London, N1 7ED, UK.
Treponematosis is a syndrome of chronic infectious diseases. There has been much debate on its origins and spread, particularly with regard to venereal syphilis, an unsightly and debilitating disease in preantibiotic populations. The osteological analysis of 5,387 individuals excavated by Museum of London Archaeology from the medieval burial ground of St. Read More
J Sex Med 2014 Dec 4;11(12):3112-8. Epub 2014 Sep 4.
University Department for Forensic Sciences, University of Split, Split, Croatia.
Introduction: There are four theories about the origin of syphilis, of which the mostly represented one is the Columbian theory. This theory suggests that syphilis was brought into Europe in 1493 ad by the ship from Caribbean islands.
Aim: The aim of this study is to test all theories on a sample of 403 skeletons: 135 from prehistory, 134 from antique, and 134 from medieval period and new age from the Dalmatia (Croatia). Read More
Int J Paleopathol 2014 Sep 5;6:34-43. Epub 2014 Apr 5.
Bone and Biomaterials Research, Center of Anatomy and Cell Biology, Medical University of Vienna, Austria. Electronic address:
Archaeological excavation of a historic cemetery in Vienna, Austria, dating to the Josephinian period (CE 1765-1790) yielded a likely case of congenital syphilis. The individual displays intensive alteration of the permanent and deciduous dentition such as the mulberry molar and a tapered, fang-like canine. Traits rarely documented in paleopathological literature such as unnotched Hutchinson's incisors or pitting on the base of the cusps of deciduous second molars complement the finding. Read More
Int J Paleopathol 2014 Mar 1;4:25-36. Epub 2014 Jan 1.
Department of Anthropology, National Museum of Natural History, Smithsonian Institution, United States.
This study describes a series of skeletal lesions observed in a mid 16th century individual of an old adult female from the Early Colonial Period of northern coastal Peru. This fragmented skeleton revealed evidence of complex, active, and systemic chronic infection that included multiple pathological foci on the cranial vault, extensive pathological new bone formation in both arms, the sternum, ribs, left scapula, clavicles, femora, and fibulae, which was paralleled by extensive endosteal obliteration of affected long bone medullary cavities. Differential diagnosis included hematogenous osteomyelitis, Paget's disease, fluorosis, melorheostosis, endosteal hyperostosis, and hypertrophic osteoarthropathy. Read More
Pan Afr Med J 2014 15;18:56. Epub 2014 May 15.
Pietro Annigoni Biomolecular Research Center (CERBA)/ (LABIOGENE), University of Ouagadougou, Burkina Faso.
Introduction: Due to the existence of a variety of types of non-venereal syphilis caused by the related T. pallidum, regular serological testing such as Rapid Plasma Reagin (RPR) and Chemiluminescent Microparticle Immunoassay Technique (CMIA) are often unable to differentiate venereal syphilis from the non- venereal one, hence, the interest in the use of molecular biology testing for a confirmation diagnosis of syphilis caused by Treponema pallidum subspecies pallidum.
Objective: The study is designed to assess the effectiveness of PCR testing and serological methods in the diagnosis of Treponema pallidum subsp pallidum among blood donors in Burkina Faso. Read More
Am J Phys Anthropol 2013 Feb 24;150(2):273-85. Epub 2012 Dec 24.
Department of Archaeology, Durham University, Durham DH1 3LE, England. c.a.roberts@ durham.ac.uk
Treponematosis has been one of the most studied and debated infectious diseases in paleopathology, particularly from the standpoint of its origin, evolution, and transmission. This study links evidence for treponematosis in skeletons from the 14th-16th century AD cemetery of the Augustinian friary of Hull Magistrates Court, England, with data from stable isotope analysis to test the hypothesis that the people with treponemal disease buried at this site were not locally born and raised. The objective is to explore the potential of using stable isotope data to track the place of origin and extent of mobility of individuals with an infectious disease. Read More
Hist Cienc Saude Manguinhos 2012 Mar;19(1):197-216
The article analyzes the Program to Eradicate Yaws, enforced in Brazil from 1956 through 1961. Following World War II, when antibiotics first came into use, it seemed there might be a method for eradicating treponematosis in a short time: a single-dose injection of penicillin. At a moment when priority was being placed on fighting rural endemic disease in Brazil, it became possible to organize a campaign against yaws. Read More
Skinmed 2012 Jan-Feb;10(1):8-12
Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India.
The venereal form of treponematosis, caused by the spirochete Treponema pallidum, plagued every major city in the preantibiotic era. "Civilization means syphilization," was an idea touted by Richard von Krafft-Ebing in the late 19th, and early 20th centuries that the effects of modern life make men more susceptible to syphilis and other diseases. Christopher Columbus was thought of as an importer of syphilis to Europe. Read More
Lancet 2012 Jan 11;379(9813):342-7. Epub 2012 Jan 11.
Lihir Medical Centre-International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.
Background: Yaws--an endemic treponematosis and, as such, a neglected tropical disease--is re-emerging in children in rural, tropical areas. Oral azithromycin is effective for syphilis. We assessed the efficacy of azithromycin compared with intramuscular long-acting penicillin to treat patients with yaws. Read More
Am J Phys Anthropol 2011 Apr 1;144(4):526-37. Epub 2010 Dec 1.
Anthropology Department, University of North Carolina at Greensboro, Greensboro, NC 27412, USA.
This study analyzed skeletal health disparities among African American and Euro-American males of low socioeconomic status born between 1825 and 1877. A total of 651 skeletons from the Cobb, Hamann-Todd, and Terry anatomical collections were macroscopically examined for skeletal pathologies related to dietary deficiencies and disease. Individuals were separated into age, ancestry, birth (Antebellum, Civil War, Pre-Reconstruction, and Reconstruction), combined ancestry/birth, enslaved versus liberated, and collection cohorts. Read More
Wien Klin Wochenschr 2008 ;120(19-20 Suppl 4):20-3
Institut für Nuklearmedizin, Wagner-Jauregg Krankenhaus, Linz, Osterreich.
Syphilis is a recurrent treponematosis of acute and chronic evolution. In general it is either sexually or congenitally transmitted. Primary syphilis appears as a single and painless lesion. Read More
Med Trop (Mars) 2008 Apr;68(2):111-8
Service de Dermatologie, Hôpital d'instruction des armées Laveran, BP 50, 13998, Marseille.
The foot is particularly exposed to injury and infection in the tropical areas. This article provides a review of the main diseases affecting the foot in the tropics including leprosy, ainhum, ulceration due to Mycobacterium ulcerans, mycetoma, chromomycosis, Kaposi's sarcoma, elephantiasis, podoconiasis, dracunculosis, tungiasis, syphilis and endemic treponematosis, larva migrans, scytalidiosis, and envenomation. Prevention is essential. Read More
Int J STD AIDS 2007 Sep;18(9):596-600
Center for International Health, University of Sherbrooke, Sherbrooke, Québec, Canada.
The combination of high sexually transmitted infection (STI) prevalence and low HIV prevalence has been described as the Indian Ocean paradox. To investigate current epidemiology of HIV and STI in the Comoros, we conducted cross-sectional surveys of a representative sample of the adult population, and convenience samples of female sex workers and male STI patients. Only one (0. Read More
Sante 2006 Oct-Dec;16(4):215-23
Institut de recherche pour le développement (IRD), Unité de recherche 178, Conditions et territoires d'émergences des maladies, Centre IRD de Hann, BP 1386, Dakar CP 18524 Sénégal.
A historical and comparative study of the origins and emergence of syphilis and AIDS show that both result from human intrusions. Treponema probably existed in primates before human infection, and nonvenereal treponemal infection existed in prehistoric tropical Africa. When humans began wearing clothes, the disappearance of endemic infection ended immunity and led to receptivity to venereal infection. Read More
Am J Phys Anthropol 2007 Apr;132(4):568-75
Ethologie-Evolution-Ecologie CNRS UMR 6552, Université Rennes 1, Station Biologique, 35380 Paimpont, France.
We evaluated the prevalence of skin lesions in a gorilla population in the Republic of Congo. The observed lesions were typical of yaws, a treponematosis described in gorillas and humans living in tropical regions. Among the 377 gorillas identified, 17% presented skin lesions, mainly on their faces. Read More
Clin Dermatol 2006 May-Jun;24(3):181-90
Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.
Despite major efforts to eradicate these disorders, yaws, bejel, and pinta (endemic treponematosis) remain serious health issues in many regions of the world. Aside from prominent skin manifestations, these diseases may also lead to significant osseous, neurologic, and ophthalmologic complications. Although progress has been made in differentiating the causative species in a research setting, a simple, specific, and sensitive diagnostic test remains elusive. Read More
Bull Soc Pathol Exot 2006 Mar;99(1):19-22
Faculté des sciences de la santé, Université Abdou Moumouni, BP 237, Niamey, Niger.
We performed a systematic screening of HIV infection and five other sexually transmitted infections on a consecutive sample of 529 female sex workers from Niamey. HIV seroprevalence rate was 30.1%, with HIV-1 profile in 93. Read More
J Wildl Dis 2005 Oct;41(4):775-82
Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, PO Box 66, FIN-00014 University of Helsinki, Finland.
Contagious mucocutaneous dermatitis is a frequently encountered disease of mountain hares (Lepidus timidus) in Finland. We describe the histopathologic changes and propose an etiologic cause for this disorder. Fifty-three cases collected during 1982-2000 were examined histologically. Read More
Clin Infect Dis 2005 May;40(10):1548; author reply 1548-9
J Coll Physicians Surg Pak 2003 Dec;13(12):719-21
Department of Orthopaedic Surgery, Jinnah Postgraduate Medical Centre, Karachi.
Symmetrical exuberant periostitis is a rare disease caused by variety of infectious and non-infectious causes. Treponematosis is one of the rare causes of this condition. We report a patient who presented with left arm swelling, secondary to onion peel periostitis of the humerus, which was caused by Treponema species. Read More
Infect Immun 2004 Nov;72(11):6561-76
Department of Medicine, University of Washington, Seattle, USA.
Treponema paraluiscuniculi, the etiologic agent of rabbit venereal syphilis, is morphologically indistinguishable from Treponema pallidum subsp. pallidum (T. pallidum), the human syphilis treponeme, and induces similar immune responses and histopathologic changes in the infected host. Read More
Reumatismo 2004 Jan-Mar;56(1):61-6
Arthritis Center of Northeast Ohio, Youngstown, 44512, USA.
Objectives: This study was conducted to test several hypotheses: 1. That rheumatoid arthritis and syphilis were New World diseases, only transmitted to the Old World subsequent to the passages of Christopher Columbus; 2. To indirectly test the hypothesis that lead poisoning was prevalent in Roman Italy by looking for its byproduct, gout; 3. Read More
Am J Phys Anthropol 2003 Jun;121(2):117-24
Wellcome Centre for the History of Medicine at University College London, University of London, London, United Kingdom.
In 1912, 68 medieval crania were excavated from a cave at Safed in the eastern Mediterranean and brought to the United Kingdom. It is only recently that these skulls have been studied for evidence of disease. One adult individual demonstrates multiple lesions of the cranial vault, compatible with treponematosis. Read More
Acta Medica (Hradec Kralove) Suppl 2003 ;46(1-2):23-31
Univerzita Karlova v Praze, Lékarská fakulta v Hradci Králové, Ustav anatomie.
Syphilis is a treponematosis clinically characterized by a primary lesion, a secondary rash affecting the skin and the mucous membranes and late lesions affecting cardiovascular and central nervous systems, viscera and bones. Off all the skeletal lesions, the most characteristic are those of the skull, most commonly affecting frontal and parietal bones and nasal and palatal region. The collection of 647 adult skulls of both sexes and 98 child and adolescent skulls from the "Broumov Ossuary" (13th - 18th century) was examined for the presence of the bone syphilis lesions. Read More
Zentralbl Bakteriol 1999 Feb;289(1):101-7
Parasite and Tropical Health Research Department of Biological Sciences, Federal University of Technology, Yola, Nigeria.
Sixty-four (4.2%) cases of yaws and forty-one (2.7%) cases of syphilis were encountered during an epidemiological survey for filariasis in the mid-Hawal river valley. Read More
J Radiol 1998 Nov;79(11):1363-6
Service d'Imagerie Médicale, HIA Laveran, Marseille.
Bone and joint localizations of treponematosis vary greatly although there are many common features. Osteal and periosteal lesions are common. We report radiographic descriptions of bone and joint treponematosis, which must not go unrecognized due to the increasing incidence of these diseases. Read More
Am J Trop Med Hyg 1998 Sep;59(3):388-92
Department of Clinical Microbiology, Institute of Clinical Pathology and Medical Research, Westmead, New South Wales, Australia.
The endemic treponematosis yaws remains a significant cause of morbidity in many tropical countries, despite mass treatment campaigns to eradicate it. An outbreak of yaws in Marup village on Karkar Island, Papua New Guinea in 1988 provided an opportunity to monitor the outcome of treatment with penicillin over an extended period. Thirty-nine children with clinical yaws (6% of 632 examined) were monitored clinically and serologically, for nearly two years after mass treatment of all villagers with the World Health Organization recommended dosages of benzathine penicillin. Read More
Am J Phys Anthropol 1998 Jun;106(2):229-48
Department of Geography and Anthropology, Louisiana State University, Baton Rouge, USA.
Descriptions of skeletal pathological conditions evident in the prehistoric Tchefuncte adolescent 16ST1-14883b are clarified. The basis is reaffirmed for assigning to the described pathological conditions a diagnostic perspective of juvenile rheumatoid arthritis or juvenile Lyme disease--a disease that mimics juvenile rheumatoid arthritis in its arthritic presentation--rather than of assigning them as representative of juvenile onset ankylosing spondylitis or other juvenile spondyloarthropathies. A hypothesis (Lewis  Am. Read More
Ned Tijdschr Geneeskd 1997 Dec;141(51):2501-13
Rijksuniversiteit, Centrum voor Fysische Antropologie, Leiden.
Objective: Identification and paleopathological analysis of the remains of the first members of the Nassau dynasty in the Netherlands.
Setting: Centre for Physical Anthropology 'Barge's Anthropologica', Leiden University. Read More
Am J Phys Anthropol 1996 May;100(1):49-55
Narasihgharaopeta Ankapalle, A.P., India.
An Iron Age (megalithic) skull recovered from a cist burial complex at Agripalle, Andhra Pradesh, India, exhibits extensive erosion of the calvarium, areas of sclerotic diploe, irregular osteitic and periosteitic lesions, and deep ulcerations with a granulomatous appearance of nodular foci due to bone remodeling. These lesions are found over the entire surface, but are less severe in the temporal region and in the occipital region below lambda. There is extensive ulceration and destruction of the orbital roof and the nasopalatine region. Read More
Acta Trop 1995 Aug;59(4):271-7
Laboratoire de Parasitologie et Epidémiologie Tropicale, CHU La Milétrie, Poitiers, France.
Seroprevalences for toxoplasmosis, malaria, rubella, cytomegalovirus, HIV and treponemal infections were evaluated among 211 pregnant women residing in the Cotonou area, Republic of Benin. One hundred and thirteen women (53.6%) had toxoplasma antibodies, 185 (87. Read More
Am J Phys Anthropol 1995 Jun;97(2):187-95
Dirección de Antropología Física, Instituto Nacional de Antropología e Historia, México, D.F.
Congenital syphilis has been diagnosed very seldom in ancient populations. The case that we examined comes from San Jeronimo's Church (17th and 18th centuries AD; Mexico City). Coffin 43 contained an incomplete skeleton of an approximately 2-year-old infant. Read More
Clin Infect Dis 1995 May;20(5):1402-8
Arthritis Center of Northeast Ohio, Youngstown 44512, USA.
Assigning responsibility for the origins of treponemal disease has been complicated because of the (diagnostic) impreciseness of the historical written record and the inability to microbiologically distinguish among the treponematoses. Bedouin skeletal remains of individuals from the Negev area of Israel who had bejel, skeletons from the Todd human skeleton collection of individuals in whom syphilis was diagnosed, and skeletal remains from Guam of individuals who had yaws were analyzed to quantitatively assess their skeletal damage. The osseous reactions, although reproducible for each variety of treponemal disease, are not uniform among these skeletons. Read More
Bull Soc Pathol Exot 1995 ;88(3):124-5
Faculté des Sciences de la Santé, Niamey, Niger.
A seroepidemiological study of endemic treponematosis (bejel) in Niger allows us to realise an anonymous non correlated screening of VIH infection in Nomads: Touaregs of Tchirozerine (Agadez), Peuls Boro of Bermo (Maradi). On the 424 Touaregs screened only one was seropositive to VIH2 infection confirmed with Western blot that means 0.23% of seroprevalency comparable to that 0. Read More
Bull Soc Pathol Exot 1995 ;88(1):24-8
Département des Maladies parasitaires et tropicales, Hôpital Bicêtre, Kremlin-Bicêtre, France.
The study describes HIV positive refugee patients, who were seen over a 3 years period at COMEDE, a dispensary for foreign nationals. COMEDE offered a HIV test to every patient, and it followed up on the disease and its prevention. Out of 5,234 tests, 328 were positive (6. Read More
J Am Acad Dermatol 1994 Dec;31(6):1075-6
Genitourin Med 1994 Aug;70(4):278-83
Academic Department of Medicine, University School of Medicine, London, UK.
Am J Phys Anthropol 1994 Apr;93(4):455-75
Department of Geography and Anthropology, Louisiana State University, Baton Rouge 70803.
A convergence of evidence from macroscopic, radiographic and histologic examination indicates that treponemal infection was present in the 16ST1 Tchefuncte Indian burial population, dated 500 B.C. to 300 A. Read More
Bull Soc Pathol Exot 1994 ;87(1):17-8
Ministère de la Santé et de la Population, Lomé, Togo.
In Togo, since 1940, yaws declared endemic has been controlled after the 1956 and 1961 eradication campaign. Nowadays, unfortunately, the mutilating treponematosis has reappeared in force. Hence, Togolese Health Officers are in search of ways and means to eradicate the disease so as to prevent handicaps for future generations. Read More
Am J Phys Anthropol 1993 Nov;92(3):249-61
Department of Sociology and Anthropology, East Carolina University, Greenville, North Carolina 27858-4353.
Examination of five central Gulf Coast Florida archaeological skeletal series (n = 547) from the late prehistoric and early historic periods reveals the presence of pathological lesions characteristic of treponemal infection. These skeletal remains of native American populations represent a crucial time regarding hypotheses about the exchange of syphilis between the Old and New World or the mutation of one treponemal infection into another. Comparison of the lesions with those observed in modern studies of treponemal infection does not support an interpretation of venereal syphilis. Read More
Am J Phys Anthropol 1993 Jun;91(2):203-13
Department of Sociology and Anthropology, Loyola University of Chicago, Illinois 60626.
An assessment of the presence and patterns of porotic hyperostosis and periosteal reactions in the skeletal population (n = 1,014) from St. Helen-on-the-Walls, York, are used to examine health and disease in urban medieval England. The analyses of these two lesions indicate that 58% of the population display evidence of porotic hyperostosis and that 21. Read More
Bull Soc Pathol Exot 1993 ;86(5):342-4
Laboratoire de référence des Mycobactéries, Cotonou, Bénin.
A study of frequency of treponematosis among pregnant women in Mother Hood of Zogbo (Cotonou) shows 5.1 +/- 2.8% of positivity with risk of 5% by TPHA and VDRL. Read More
Hist Philos Life Sci 1993 ;15(3):313-27
The European-American exchange of infectious diseases was responsible for the demographic havoc of the native population in the New World after 1492. Prior to this date medical writers describe the presence in Spain of viral diseases like influenza, parotitis, smallpox, measles, poliomyelitis, and rabies; there were also rickettsiasis, diphtheria, salmonellosis, plague, tubercolosis, leprosy, malaria, scabies and tinea. In America, before European arrivals, there were no records of human viral diseases, though there were records of rickettsiasis, treponematosis--pinta, yaws and syphilis--leihsmaniasis, amibiasis and perhaps leprosy. Read More
Hum Biol 1992 Jun;64(3):337-60
Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC 20560.
One of the objectives of paleopathology is to clarify the role of disease in the evolution of human groups. The recovery of DNA and immunoglobulins from archeological human skeletal tissue offers a method for enhancing and expanding our knowledge about the presence and significance of disease in past human populations. DNA also might reveal the presence of genetic disease. Read More