129 results match your criteria Treponematosis Endemic Syphilis

Syphilis in an Italian medieval jewish community: A bioarchaeological and cultural perspective.

Int J Paleopathol 2020 09 20;30:85-97. Epub 2020 Jun 20.

Dept. of Biological, Geological and Environmental Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

Objectives: We aim to discuss the presence of treponemal infections in three individuals belonging to a large (∼400 individuals) Late Medieval cemetery (14th -16th century) that archaeological and documentary sources place within a Jewish context, and to discuss the role of these diseases in a biocultural perspective.

Materials And Methods: An anthropological and paleopathological study was conducted on skeletal remains of three individuals, though macroscopic and tomographic examination.

Results: Cranial lesions in which simultaneous destructive and proliferative processes (caries sicca) are noted. Read More

View Article and Full-Text PDF
September 2020

Treponematosis in a pre-Columbian hunter-gatherer male from Antofagasta (1830 ± 20 BP, Northern Coast of Chile).

Int J Paleopathol 2020 09 5;30:10-16. Epub 2020 Mar 5.

OSTeam Ltda., Santiago, Chile.

Objective: This paper reports a new case of treponemal disease in a pre-Columbian hunter-gatherer inhabiting the desert coast of South America.

Materials: A well-preserved adult male skeleton from the "Vertedero Municipal" archaeological cemetery, located near the city of Antofagasta (Northern Chile).

Methods: The skeleton was radiocarbon dated, and isotopic analyses were performed to assess diet and mobility. Read More

View Article and Full-Text PDF
September 2020

First report of hare treponematosis seroprevalence of European brown hares (Lepus europaeus) in the Czech Republic: seroprevalence negatively correlates with altitude of sampling areas.

BMC Vet Res 2019 Oct 18;15(1):350. Epub 2019 Oct 18.

Department of Biology, Faculty of Medicine, Masaryk University, Kamenice 5, Building A6, 625 00, Brno, Czech Republic.

Background: The aim of this study was to quantify the seroprevalence of hare treponematosis in European brown hare (Lepus europaeus) populations in the Czech Republic and to test for an association between treponematosis prevalence and the altitude of the areas in which hares were sampled. We tested 289 serum samples of brown hares collected between 2015 and 2017. The sampling areas included 12 districts (73 villages) distributed throughout the Czech Republic. Read More

View Article and Full-Text PDF
October 2019

The "Scourge of the Renaissance". A Short Review About infection.

Endocr Metab Immune Disord Drug Targets 2020 ;20(3):335-343

Department of Emergency/Urgent, National Poison Center, Riuniti University Hospital (OO.RR.) of Foggia, Foggia, Italy.

Background: There is not a time in the history when epidemics did not loom large: infectious diseases have always had civilisation and evolution-altering consequences. Throughout history, there have been a number of pandemics: cholera, bubonic plague, influenza, smallpox are some of the most brutal killers in human history. Historical accounts of pandemics clearly demonstrate that war, unhygienic conditions, social and health inequality create conditions for the transmission of infectious diseases, and existing health disparities can contribute to unequal morbidity and mortality. Read More

View Article and Full-Text PDF
January 2021

Bejel, a Nonvenereal Treponematosis, among Men Who Have Sex with Men, Japan.

Emerg Infect Dis 2019 08;25(8):1581-1583

Bejel, an endemic treponematosis caused by infection with Treponema pallidum subspecies endemicum, has not been reported in eastern Asia and the Pacific region. We report local spread of bejel among men who have sex with men in Japan. Spread was complicated by venereal syphilis. Read More

View Article and Full-Text PDF

Molecular detection of Treponema pallidum subspecies pallidum in 150-year-old foetal remains, southeastern France.

J Med Microbiol 2019 May 17;68(5):761-769. Epub 2019 Apr 17.

Aix-Marseille Univ, CNRS, EFS, ADES, Marseille, France.

Purpose: Syphilis, caused by Treponema pallidum subspecies pallidum , is considered as an old disease affecting humans; traces of such infections, including congenital syphilis, are potentially identifiable in archaeological samples. The aim of this research was to perform macroscopic and molecular investigations of T. pallidum on six infant remains, buried between 1837 and 1867, from the cemetery of 'Les Crottes' in Marseille city (southeastern France). Read More

View Article and Full-Text PDF

Circulation of Distinct Strains in Individuals with Heterosexual Orientation and Men Who Have Sex with Men.

J Clin Microbiol 2019 01 2;57(1). Epub 2019 Jan 2.

Department of Clinical Laboratory, National Hospital Organization, Nagoya Medical Center, Nagoya, Japan.

Human treponematosis is caused by various pathogenic subspecies, including subsp. , subsp. , subsp. Read More

View Article and Full-Text PDF
January 2019

Bejel in Cuba: molecular identification of Treponema pallidum subsp. endemicum in patients diagnosed with venereal syphilis.

Clin Microbiol Infect 2018 Nov 16;24(11):1210.e1-1210.e5. Epub 2018 Feb 16.

Department of Biology, Masaryk University, Brno, 625 00, Czech Republic. Electronic address:

Objectives: Bejel, caused by Treponema pallidum subsp. endemicum (TEN), was until now considered as a non-venereal disease endemic in areas with hot and dry climates. This study has identified TEN in clinical samples from Cuban patients previously diagnosed with syphilis. Read More

View Article and Full-Text PDF
November 2018

Eradicating successfully yaws from India: The strategy & global lessons.

Indian J Med Res 2015 May;141(5):608-13

Epidemiology & Epidemic Intelligence Service (EIS), National Centre for Disease Control (NCDC), Delhi, India.

Yaws, a non-venereal treponematosis, affecting primarily the tribal populations, has been considered historically as one of the most neglected tropical diseases in the world. In 1996, India piloted an initiative to eradicate yaws based on a strategy consisting of active case finding through house-to-house search and treatment of cases and their contacts with long acting penicillin. Thereafter, the campaign implemented in all 51 endemic districts in 10 states of the country led to the achievement of a yaws-free status in 2004. Read More

View Article and Full-Text PDF

Evidence of skeletal treponematosis from the medieval burial ground of St. Mary Spital, London, and implications for the origins of the disease in Europe.

Am J Phys Anthropol 2015 Jan 6;156(1):90-101. Epub 2014 Oct 6.

Museum of London Archaeology, London, N1 7ED, UK.

Treponematosis is a syndrome of chronic infectious diseases. There has been much debate on its origins and spread, particularly with regard to venereal syphilis, an unsightly and debilitating disease in preantibiotic populations. The osteological analysis of 5,387 individuals excavated by Museum of London Archaeology from the medieval burial ground of St. Read More

View Article and Full-Text PDF
January 2015

Which theory for the origin of syphilis is true?

J Sex Med 2014 Dec 4;11(12):3112-8. Epub 2014 Sep 4.

University Department for Forensic Sciences, University of Split, Split, Croatia.

Introduction: There are four theories about the origin of syphilis, of which the mostly represented one is the Columbian theory. This theory suggests that syphilis was brought into Europe in 1493 ad by the ship from Caribbean islands.

Aim: The aim of this study is to test all theories on a sample of 403 skeletons: 135 from prehistory, 134 from antique, and 134 from medieval period and new age from the Dalmatia (Croatia). Read More

View Article and Full-Text PDF
December 2014

Importance of extending the use of polymerase chain reaction in the diagnosis of venereal syphilis in a blood transfusion center in Burkina Faso, West Africa.

Pan Afr Med J 2014 15;18:56. Epub 2014 May 15.

Pietro Annigoni Biomolecular Research Center (CERBA)/ (LABIOGENE), University of Ouagadougou, Burkina Faso.

Introduction: Due to the existence of a variety of types of non-venereal syphilis caused by the related T. pallidum, regular serological testing such as Rapid Plasma Reagin (RPR) and Chemiluminescent Microparticle Immunoassay Technique (CMIA) are often unable to differentiate venereal syphilis from the non- venereal one, hence, the interest in the use of molecular biology testing for a confirmation diagnosis of syphilis caused by Treponema pallidum subspecies pallidum.

Objective: The study is designed to assess the effectiveness of PCR testing and serological methods in the diagnosis of Treponema pallidum subsp pallidum among blood donors in Burkina Faso. Read More

View Article and Full-Text PDF

Isotopic tracing of the impact of mobility on infectious disease: The origin of people with treponematosis buried in hull, England, in the late medieval period.

Am J Phys Anthropol 2013 Feb 24;150(2):273-85. Epub 2012 Dec 24.

Department of Archaeology, Durham University, Durham DH1 3LE, England. [email protected] durham.ac.uk

Treponematosis has been one of the most studied and debated infectious diseases in paleopathology, particularly from the standpoint of its origin, evolution, and transmission. This study links evidence for treponematosis in skeletons from the 14th-16th century AD cemetery of the Augustinian friary of Hull Magistrates Court, England, with data from stable isotope analysis to test the hypothesis that the people with treponemal disease buried at this site were not locally born and raised. The objective is to explore the potential of using stable isotope data to track the place of origin and extent of mobility of individuals with an infectious disease. Read More

View Article and Full-Text PDF
February 2013

Origin and evolution of syphilis: drifting myth.

Skinmed 2012 Jan-Feb;10(1):8-12

Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India.

The venereal form of treponematosis, caused by the spirochete Treponema pallidum, plagued every major city in the preantibiotic era. "Civilization means syphilization," was an idea touted by Richard von Krafft-Ebing in the late 19th, and early 20th centuries that the effects of modern life make men more susceptible to syphilis and other diseases. Christopher Columbus was thought of as an importer of syphilis to Europe. Read More

View Article and Full-Text PDF
February 2012

Single-dose azithromycin versus benzathine benzylpenicillin for treatment of yaws in children in Papua New Guinea: an open-label, non-inferiority, randomised trial.

Lancet 2012 Jan 11;379(9813):342-7. Epub 2012 Jan 11.

Lihir Medical Centre-International SOS, Newcrest Mining, Lihir Island, Papua New Guinea.

Background: Yaws--an endemic treponematosis and, as such, a neglected tropical disease--is re-emerging in children in rural, tropical areas. Oral azithromycin is effective for syphilis. We assessed the efficacy of azithromycin compared with intramuscular long-acting penicillin to treat patients with yaws. Read More

View Article and Full-Text PDF
January 2012

[SPECT and FDG-PET in diagnostics of neurolues].

Wien Klin Wochenschr 2008 ;120(19-20 Suppl 4):20-3

Institut für Nuklearmedizin, Wagner-Jauregg Krankenhaus, Linz, Osterreich.

Syphilis is a recurrent treponematosis of acute and chronic evolution. In general it is either sexually or congenitally transmitted. Primary syphilis appears as a single and painless lesion. Read More

View Article and Full-Text PDF

[Foot health in the tropics].

J J Morand

Med Trop (Mars) 2008 Apr;68(2):111-8

Service de Dermatologie, Hôpital d'instruction des armées Laveran, BP 50, 13998, Marseille.

The foot is particularly exposed to injury and infection in the tropical areas. This article provides a review of the main diseases affecting the foot in the tropics including leprosy, ainhum, ulceration due to Mycobacterium ulcerans, mycetoma, chromomycosis, Kaposi's sarcoma, elephantiasis, podoconiasis, dracunculosis, tungiasis, syphilis and endemic treponematosis, larva migrans, scytalidiosis, and envenomation. Prevention is essential. Read More

View Article and Full-Text PDF

The Indian Ocean paradox revisited: HIV and sexually transmitted infections in the Comoros.

Int J STD AIDS 2007 Sep;18(9):596-600

Center for International Health, University of Sherbrooke, Sherbrooke, Québec, Canada.

The combination of high sexually transmitted infection (STI) prevalence and low HIV prevalence has been described as the Indian Ocean paradox. To investigate current epidemiology of HIV and STI in the Comoros, we conducted cross-sectional surveys of a representative sample of the adult population, and convenience samples of female sex workers and male STI patients. Only one (0. Read More

View Article and Full-Text PDF
September 2007

[A comparative study of the emergence of the AIDS and syphilis pandemics].

Sante 2006 Oct-Dec;16(4):215-23

Institut de recherche pour le développement (IRD), Unité de recherche 178, Conditions et territoires d'émergences des maladies, Centre IRD de Hann, BP 1386, Dakar CP 18524 Sénégal.

A historical and comparative study of the origins and emergence of syphilis and AIDS show that both result from human intrusions. Treponema probably existed in primates before human infection, and nonvenereal treponemal infection existed in prehistoric tropical Africa. When humans began wearing clothes, the disappearance of endemic infection ended immunity and led to receptivity to venereal infection. Read More

View Article and Full-Text PDF

Yaws disease in a wild gorilla population and its impact on the reproductive status of males.

Am J Phys Anthropol 2007 Apr;132(4):568-75

Ethologie-Evolution-Ecologie CNRS UMR 6552, Université Rennes 1, Station Biologique, 35380 Paimpont, France.

We evaluated the prevalence of skin lesions in a gorilla population in the Republic of Congo. The observed lesions were typical of yaws, a treponematosis described in gorillas and humans living in tropical regions. Among the 377 gorillas identified, 17% presented skin lesions, mainly on their faces. Read More

View Article and Full-Text PDF

Endemic treponematosis: review and update.

Clin Dermatol 2006 May-Jun;24(3):181-90

Department of Dermatology, Baylor College of Medicine, Houston, TX 77030, USA.

Despite major efforts to eradicate these disorders, yaws, bejel, and pinta (endemic treponematosis) remain serious health issues in many regions of the world. Aside from prominent skin manifestations, these diseases may also lead to significant osseous, neurologic, and ophthalmologic complications. Although progress has been made in differentiating the causative species in a research setting, a simple, specific, and sensitive diagnostic test remains elusive. Read More

View Article and Full-Text PDF
January 2007

Bilateral treponema periostitis.

J Coll Physicians Surg Pak 2003 Dec;13(12):719-21

Department of Orthopaedic Surgery, Jinnah Postgraduate Medical Centre, Karachi.

Symmetrical exuberant periostitis is a rare disease caused by variety of infectious and non-infectious causes. Treponematosis is one of the rare causes of this condition. We report a patient who presented with left arm swelling, secondary to onion peel periostitis of the humerus, which was caused by Treponema species. Read More

View Article and Full-Text PDF
December 2003

Tpr homologs in Treponema paraluiscuniculi Cuniculi A strain.

Infect Immun 2004 Nov;72(11):6561-76

Department of Medicine, University of Washington, Seattle, USA.

Treponema paraluiscuniculi, the etiologic agent of rabbit venereal syphilis, is morphologically indistinguishable from Treponema pallidum subsp. pallidum (T. pallidum), the human syphilis treponeme, and induces similar immune responses and histopathologic changes in the infected host. Read More

View Article and Full-Text PDF
November 2004

"Like a virgin": Absence of rheumatoid arthritis and treponematosis, good sanitation and only rare gout in Italy prior to the 15th century.

Reumatismo 2004 Jan-Mar;56(1):61-6

Arthritis Center of Northeast Ohio, Youngstown, 44512, USA.

Objectives: This study was conducted to test several hypotheses: 1. That rheumatoid arthritis and syphilis were New World diseases, only transmitted to the Old World subsequent to the passages of Christopher Columbus; 2. To indirectly test the hypothesis that lead poisoning was prevalent in Roman Italy by looking for its byproduct, gout; 3. Read More

View Article and Full-Text PDF

Pre-Columbian treponemal disease from 14th century AD Safed, Israel, and implications for the medieval eastern Mediterranean.

Piers D Mitchell

Am J Phys Anthropol 2003 Jun;121(2):117-24

Wellcome Centre for the History of Medicine at University College London, University of London, London, United Kingdom.

In 1912, 68 medieval crania were excavated from a cave at Safed in the eastern Mediterranean and brought to the United Kingdom. It is only recently that these skulls have been studied for evidence of disease. One adult individual demonstrates multiple lesions of the cranial vault, compatible with treponematosis. Read More

View Article and Full-Text PDF

[Findings of the syphilis lesions in the skulls from the "Broumov Ossuary"].

Acta Medica (Hradec Kralove) Suppl 2003 ;46(1-2):23-31

Univerzita Karlova v Praze, Lékarská fakulta v Hradci Králové, Ustav anatomie.

Syphilis is a treponematosis clinically characterized by a primary lesion, a secondary rash affecting the skin and the mucous membranes and late lesions affecting cardiovascular and central nervous systems, viscera and bones. Off all the skeletal lesions, the most characteristic are those of the skull, most commonly affecting frontal and parietal bones and nasal and palatal region. The collection of 647 adult skulls of both sexes and 98 child and adolescent skulls from the "Broumov Ossuary" (13th - 18th century) was examined for the presence of the bone syphilis lesions. Read More

View Article and Full-Text PDF

Yaws and syphilis in the Garkida area of Nigeria.

O B Akogun

Zentralbl Bakteriol 1999 Feb;289(1):101-7

Parasite and Tropical Health Research Department of Biological Sciences, Federal University of Technology, Yola, Nigeria.

Sixty-four (4.2%) cases of yaws and forty-one (2.7%) cases of syphilis were encountered during an epidemiological survey for filariasis in the mid-Hawal river valley. Read More

View Article and Full-Text PDF
February 1999

[Osteoarticular involvement in parasitic diseases: bone treponematosis].

J Radiol 1998 Nov;79(11):1363-6

Service d'Imagerie Médicale, HIA Laveran, Marseille.

Bone and joint localizations of treponematosis vary greatly although there are many common features. Osteal and periosteal lesions are common. We report radiographic descriptions of bone and joint treponematosis, which must not go unrecognized due to the increasing incidence of these diseases. Read More

View Article and Full-Text PDF
November 1998

Failure of penicillin treatment of yaws on Karkar Island, Papua New Guinea.

Am J Trop Med Hyg 1998 Sep;59(3):388-92

Department of Clinical Microbiology, Institute of Clinical Pathology and Medical Research, Westmead, New South Wales, Australia.

The endemic treponematosis yaws remains a significant cause of morbidity in many tropical countries, despite mass treatment campaigns to eradicate it. An outbreak of yaws in Marup village on Karkar Island, Papua New Guinea in 1988 provided an opportunity to monitor the outcome of treatment with penicillin over an extended period. Thirty-nine children with clinical yaws (6% of 632 examined) were monitored clinically and serologically, for nearly two years after mass treatment of all villagers with the World Health Organization recommended dosages of benzathine penicillin. Read More

View Article and Full-Text PDF
September 1998